FOXO3
July 27, 2019
KLOTHO
July 30, 2019
Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses.
Fibroblast growth factor 21 (FGF21) is a hormone-like member of FGF family which controls metabolic multiorgan crosstalk enhancing energy expenditure through glucose and lipid metabolism. In addition, FGF21 acts as a stress hormone induced by endoplasmic reticulum stress and dysfunctions of mitochondria and autophagy in several tissues. FGF21 also controls stress responses and metabolism by modulating the functions of somatotropic axis and hypothalamic-pituitary-adrenal (HPA) pathway. FGF21 is a potent longevity factor coordinating interactions between energy metabolism and stress responses. Recent studies have revealed that FGF21 treatment can alleviate many age-related metabolic disorders, e.g. atherosclerosis, obesity, type 2 diabetes, and some cardiovascular diseases. In addition, transgenic mice overexpressing FGF21 have an extended lifespan. However, chronic metabolic and stress-related disorders involving inflammatory responses can provoke FGF21 resistance and thus disturb healthy aging process. First, we will describe the role of FGF21 in interorgan energy metabolism and explain how its functions as a stress hormone can improve healthspan. Next, we will examine both the induction of FGF21 expression via the integrated stress response and the molecular mechanism through which FGF21 enhances healthy aging. Finally, we postulate that FGF21 resistance, similarly to insulin resistance, jeopardizes human healthspan and accelerates the aging process
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of the adaptive starvation response. Among its effects, FGF21 induces hepatic fatty acid oxidation and ketogenesis, increases insulin sensitivity, blocks somatic growth and causes bone loss. Here we show that transgenic overexpression of FGF21 markedly extends lifespan in mice without reducing food intake or affecting markers of NAD+ metabolism or AMP kinase and mTOR signaling. Transcriptomic analysis suggests that FGF21 acts primarily by blunting the growth hormone/insulin-like growth factor-1 signaling pathway in liver. These findings raise the possibility that FGF21 can be used to extend lifespan in other species.
Liver-derived metabolic hormone fibroblast growth factor 21 (FGF21) improves insulin sensitivity and extends lifespan in mice. Aging also compromises the adaptive immune system by reducing T-cell production from the thymus. In this paper, we describe a new immunological function of FGF21 as a regulator of T-cell production from thymus in aging. The overexpression of FGF21 prevents thymic lipoatrophy, which protects the mice from age-induced loss of naïve T cells. FGF21 expression in thymic epithelial cells and signaling in thymic stromal cells support thymic function in aging. Loss of FGF21 in mice increases lethality postirradiation and delays the reconstitution of thymus. Hence, we highlight FGF21 as an immunometabolic regulator that can be harnessed to delay immune senescence.
Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans
•Shivering stimulates irisin secretion in humans
•Nonshivering cold exposure increases FGF21, which may be a brown adipokine
•Irisin and/or FGF21 upregulates brown-fat-like program in human adipocytes
•Exercise may be a shivering mimic exemplifying muscle-fat thermogenic crosstalk
Rediscovery of cold-activated brown adipose tissue (BAT) in humans has boosted research interest in identifying BAT activators for metabolic benefits. Of particular interest are cytokines capable of fat browning. Irisin, derived from FNDC5, is an exercise-induced myokine that drives brown-fat-like thermogenesis in murine white fat. Here we explored whether cold exposure is an afferent signal for irisin secretion in humans and compared it with FGF21, a brown adipokine in rodents. Cold exposure increased circulating irisin and FGF21. We found an induction of irisin secretion proportional to shivering intensity, in magnitude similar to exercise-stimulated secretion. FNDC5 and/or FGF21 treatment upregulated human adipocyte brown fat gene/protein expression and thermogenesis in a depot-specific manner. These results suggest exercise-induced irisin secretion could have evolved from shivering-related muscle contraction, serving to augment brown fat thermogenesis in concert with FGF21. Irisin-mediated muscle-adipose crosstalk may represent a thermogenic, cold-activated endocrine axis that is exploitable in obesity therapeutics development.
The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man
FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated by PPARα in rodents. However, the physiological role of FGF21 in man is not yet defined and was investigated in our study. Serum FGF21 varied 250-fold among 76 healthy individuals and did not relate to age, gender, body mass index (BMI), serum lipids, or plasma glucose. FGF21 levels had no diurnal variation and were unrelated to bile acid or cholesterol synthesis. Ketosis induced by a 2 day fast or feeding a ketogenic diet (KD) did not influence FGF21 levels, whereas a 74% increase occurred after 7 days of fasting. Hypertriglyceridemic nondiabetic patients had 2-fold elevated FGF21 levels, which were further increased by 28% during fenofibrate treatment. FGF21 circulates in human plasma and increases by extreme fasting and PPARα activation. The wide interindividual variation and the induction of ketogenesis independent of FGF21 levels indicate that the physiological role of FGF21 in humans may differ from that in mice.
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- FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
- PPARα is a key regulator of hepatic FGF21
- FGF21 is an Akt‐regulated myokine
- Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State
- Thermogenic Activation Induces FGF21 Expression and Release in Brown Adipose Tissue
- Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans
- Irisin and FGF21 Are Cold-Induced Endocrine Activators of Brown Fat Function in Humans
- Understanding the Physiology of FGF21
- The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes
- FGF21 is an endocrine signal of protein restriction
- Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21
- The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man
- FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
- Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21
- An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
- Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
- Inventing new medicines: The FGF21 story
- Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice
- FGF21 regulates metabolism and circadian behavior by acting on the nervous system
- Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding
- FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss
- The fasting polypeptide FGF21 can enter brain from blood
- FGF21 Regulates Sweet and Alcohol Preference
- FGF21 contributes to neuroendocrine control of female reproduction
- FGF21 Requires βklotho to Act In Vivo
- FGF21 attenuates lipolysis in human adipocytes – A possible link to improved insulin sensitivity
- Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by Induction of FGF21
- FGF21 reloaded: challenges of a rapidly growing field
- FGF21: A Missing Link in the Biology of Fasting
- Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21
- Acute Exercise Induces FGF21 Expression in Mice and in Healthy Humans
- Interplay between FGF21 and insulin action in the liver regulates metabolism
- Serum Levels of the Adipokine FGF21 Depend on Renal Function
- FGF21-based pharmacotherapy – potential utility for metabolic disorders
- Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21) in Vivo
- FGF21: A novel prospect for the treatment of metabolic diseases
- Exercise Increases Serum Fibroblast Growth Factor 21 (FGF21) Levels
- TNF-α Represses β-Klotho Expression and Impairs FGF21 Action in Adipose Cells: Involvement of JNK1 in the FGF21 Pathway
- Fructose ingestion acutely stimulates circulating FGF21 levels in humans
- Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat
- Metformin stimulates FGF21 expression in primary hepatocytes
- Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
- Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease
- FGF21 N‐ and C‐termini play different roles in receptor interaction and activation
- Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes
- FGF21 Revolutions: Recent Advances Illuminating FGF21 Biology and Medicinal Properties
- Novel locus including FGF21 is associated with dietary macronutrient intake
- Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice
- Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
- Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects
- Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue
- Paradoxical Regulation of Human FGF21 by Both Fasting and Feeding Signals: Is FGF21 a Nutritional Adaptation Factor?
- FGF21 as a hepatokine, adipokine, and myokine in metabolism and diseases
- Different roles of N‐ and C‐ termini in the functional activity of FGF21
- FGF21 Takes a Fat Bite
- Nrf2 Represses FGF21 During Long-Term High-Fat Diet–Induced Obesity in Mice
- Fibroblast Growth Factor 21 (FGF21) in Human Cerebrospinal Fluid
- FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents
- FGF21 Promotes Metabolic Homeostasis via White Adipose and Leptin in Mice
- FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver
- Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex
- PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis
- Mild Cold Exposure Modulates Fibroblast Growth Factor 21 (FGF21) Diurnal Rhythm in Humans: Relationship between FGF21 Levels, Lipolysis, and Cold-Induced Thermogenesis
- Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity
- Lack of Overt FGF21 Resistance in Two Mouse Models of Obesity and Insulin Resistance
- Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1
- LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys
- FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases
- FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting
- Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo
- Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21
- Endocrine Protection of Ischemic Myocardium by FGF21 from the Liver and Adipose Tissue
- Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB
- Regulation of FGF21 Expression and Secretion by Retinoic Acid Receptor-related Orphan Receptor α
- FGF21 and the late adaptive response to starvation in humans
- FGF21 mediates the lipid metabolism response to amino acid starvation
- FGF21 polypeptides comprising two or more mutations
- Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice
- FGF21 mutants and uses thereof
- Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine
- Understanding the Physical Interactions in the FGF21/FGFR/β‐Klotho Complex: Structural Requirements and Implications in FGF21 Signaling
- FGF21 as a Therapeutic Reagent
- Circadian expression of FGF21 is induced by PPARα activation in the mouse liver
- A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects
- FGF21 Mimetic Shows Therapeutic Promise
- Serum FGF21 levels are associated with brown adipose tissue activity in humans
- FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms
- Stressed liver and muscle call on adipocytes with FGF21
- Restoration of leptin responsiveness in diet‐induced obese mice using an optimized leptin analog in combination with exendin‐4 or FGF21
- Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework
- FGF21 as an endocrine regulator in lipid metabolism: from molecular evolution to physiology and pathophysiology
- Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys
- FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues
- Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes
- Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
- Fgf21 is essential for haematopoiesis in zebrafish
- FGF21: The Center of a Transcriptional Nexus in Metabolic Regulation
- Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation
- Novel Insights into the Cardio-Protective Effects of FGF21 in Lean and Obese Rat Hearts
- Human HMGCS2 Regulates Mitochondrial Fatty Acid Oxidation and FGF21 Expression in HepG2 Cell Line
- Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients
- Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress
- KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
- Plasma FGF21 Is Elevated by the Intense Lipid Mobilization of Lactation
- ATF4- and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress
- The PPARα-FGF21 Hormone Axis Contributes to Metabolic Regulation by the Hepatic JNK Signaling Pathway
- FGF21 and cardiac physiopathology
- Fibroblast Growth Factor 21 (FGF21) Inhibits Chondrocyte Function and Growth Hormone Action Directly at the Growth Plate
- FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders
- High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coli
- FGF21 Is Increased by Inflammatory Stimuli and Protects Leptin-Deficient ob/ob Mice from the Toxicity of Sepsis
- Development of a Novel Long-Acting Antidiabetic FGF21 Mimetic by Targeted Conjugation to a Scaffold Antibody
- Role of Fibroblast Growth Factor 21 (FGF21) in Undernutrition-Related Attenuation of Growth
- Circulating FGF21 Levels Are Progressively Increased from the Early to End Stages of Chronic Kidney Diseases and Are Associated with Renal Function in Chinese
- FGF21 mutant fusion polypeptides and uses thereof
- Liver-Enriched Transcription Factor CREBH Interacts With Peroxisome Proliferator-Activated Receptor α to Regulate Metabolic Hormone FGF21
- Polyethylene Glycol Modified FGF21 Engineered to Maximize Potency and Minimize Vacuole Formation
- Circulating FGF21 proteolytic processing mediated by fibroblast activation protein
- A new frontier in FGF21 biology
- Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin
- The Role of Fibroblast Growth Factor 21 (FGF21) on Energy Balance, Glucose and Lipid Metabolism
- The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes
- FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans
- FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism
- FGF21 mutants and uses thereof
- A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism
- Transcriptional Repressor E4-binding Protein 4 (E4BP4) Regulates Metabolic Hormone Fibroblast Growth Factor 21 (FGF21) during Circadian Cycles and Feeding
- Plasma FGF21 displays a circadian rhythm during a 72‐h fast in healthy female volunteers
- Glucocorticoids Regulate the Metabolic Hormone FGF21 in a Feed-Forward Loop
- FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1
- Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21
- Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2
- Long-Term Cold Adaptation Does Not Require FGF21 or UCP1
- Liver Fat But Not Other Adiposity Measures Influence Circulating FGF21 Levels in Healthy Young Adult Twins
- Impaired Mitochondrial Fat Oxidation Induces FGF21 in Muscle
- Fgf21 mutants and uses thereof
- Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution
- iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy
- Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion
- A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption
- Fibroblast Growth Factor 21 (FGF21) and Glucagon-Like Peptide 1 Contribute to Diabetes Resistance in Glucagon Receptor–Deficient Mice
- Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21
- Pharmacokinetics and pharmacodynamics of PF‐05231023, a novel long‐acting FGF21 mimetic, in a first‐in‐human study
- Increased HO‐1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21
- Glucagon Stimulates Hepatic FGF21 Secretion through a PKA- and EPAC-Dependent Posttranscriptional Mechanism
- Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas
- FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling
- Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?
- A Novel Approach to Improve the Function of FGF21
- Fatty liver and FGF21 physiology
- FGF21 Is an Exocrine Pancreas Secretagogue
- Ketogenic Diet Impairs FGF21 Signaling and Promotes Differential Inflammatory Responses in the Liver and White Adipose Tissue
- FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice
- FGF21 mutants multimers and uses thereof
- Central Resistin/TLR4 Impairs Adiponectin Signaling, Contributing to Insulin and FGF21 Resistance
- Distinct association of serum FGF21 or adiponectin levels with clinical parameters in patients with type 2 diabetes
- FGF21 derivatives with albumin binder A-B-C-D-E- and their use
- FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia
- FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein
- Serum FGF21 levels are increased in newly diagnosed type 2 diabetes with nonalcoholic fatty liver disease and associated with hsCRP levels independently
- Dynamic Change of Serum FGF21 Levels in Response to Glucose Challenge in Human
- The FGF21–adiponectin axis in controlling energy and vascular homeostasis
- Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action
- Fibroblast growth factor (FGF21) protects mouse liver against d-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways
- Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial- and endoplasmic reticulum stress-dependent pathways in the mouse model
- Fgf21 Impairs Adipocyte Insulin Sensitivity in Mice Fed a Low-Carbohydrate, High-Fat Ketogenic Diet
- Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy
- FGF21 polypeptides comprising two or more mutations and uses thereof
- FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process
- FGF21 upregulates expression of GLUT-1 in a βklotho-dependent manner
- Pegylated Fgf21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice
- OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance
- Differential Enzyme-Linked Immunosorbent Assay and Ligand-Binding Mass Spectrometry for Analysis of Biotransformation of Protein Therapeutics: Application to Various FGF21 Modalities
- Increased FGF21 plasma levels in humans with sepsis and SIRS
- Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates
- Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21
- Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet
- Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients
- Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron–sulfur cluster depletion in human skeletal muscle
- FGF21 as a mediator of adaptiveresponses to stress and metabolicbenefits of anti-diabetic drugs
- FGF21 is dispensable for hypothermia induced by fasting in mice.
- Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway
- Serum FGF21 increases with hepatic fat accumulation in pediatric onset intestinal failure
- FGF19 and FGF21 serum concentrations in human obesity and type 2 diabetes behave differently after diet- or surgically-induced weight loss
- Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting Saposin-like Protein (Msap)
- CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis
- Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α pathway
- Impact of short-term high-fat feeding and insulin-stimulated FGF21 levels in subjects with low birth weight and controls
- Hormone Resistance in Diabetes and Obesity: Insulin, Leptin, and FGF21
- Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice
- FGF21 and the Second Coming of PPARγ
- Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21
- Serum FGF21 levels in adult m.3243A>G carriers
- Fibroblast growth factor 21 (FGF21) inhibits macrophage-mediated inflammation by activating Nrf2 and suppressing the NF-κB signaling pathway
- FGF10 and FGF21 as Regulators in Adipocyte Development and Metabolism
- Chimeric FGF21 proteins with enhanced binding affinity for β-klotho for the treatment of type II diabetes, obesity, and related metabolic disorders
- mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes
- Exercise-Induced Secretion of FGF21 and Follistatin Are Blocked by Pancreatic Clamp and Impaired in Type 2 Diabetes
- Interactions between FGF21 and BMP-2 in osteogenesis
- FGF21 Increases Cholesterol Efflux by Upregulating ABCA1 Through the ERK1/2–PPARγ–LXRα Pathway in THP1 Macrophage-Derived Foam Cells
- Uses of FGF21 polypeptides comprising two or more mutations
- FGF21 Reverses Hepatic Steatosis, Increases Energy Expenditure and Improves Insulin Sensitivity in Diet-induced Obese Mice
- Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases
- Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control
- Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice
- Autofluorescence Imaging of Living Pancreatic Islets Reveals Fibroblast Growth Factor-21 (FGF21)-Induced Metabolism
- Overexpression of β-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity
- FGF21 Mediates the Thermogenic and Insulin-Sensitizing Effects of Dietary Methionine Restriction but Not Its Effects on Hepatic Lipid Metabolism
- Diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of PPARalpha and FGF21 in mice with hepatic ablation of brain-derived neurotropic factor.
- FGF21, energy expenditure and weight loss – How much brown fat do you need?
- An engineered FGF21 variant, LY2405319, can prevent non-alcoholic steatohepatitis by enhancing hepatic mitochondrial function
- The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity
- FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue
- FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance
- Plasma FGF21 levels are increased in patients with hypothyroidism independently of lipid profile
- FGF21 signalling pathway and metabolic traits – genetic association analysis
- FGF21 suppresses hepatic glucose production through the activation of atypical protein kinase Cι/λ
- Recruitment of Histone Methyltransferase G9a Mediates Transcriptional Repression of Fgf21 Gene by E4BP4 Protein
- High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice
- Lower Cerebrospinal Fluid/Plasma Fibroblast Growth Factor 21 (FGF21) Ratios and Placental FGF21 Production in Gestational Diabetes
- Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway
- FGF21 ameliorates nonalcoholic fatty liver disease by inducing autophagy
- FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases
- Leptin as a Potential Regulator of FGF21
- FGF21 Response to Critical Illness: Effect of Blood Glucose Control and Relation With Cellular Stress and Survival
- Long-acting hypoglycemic effects of PEGylated FGF21 and insulin glargine in mice with type 1 diabetes
- Elevated FGF21 Leads to Attenuated Postnatal Linear Growth in Preterm Infants Through GH Resistance in Chondrocytes
- Lactate induces FGF21 expression in adipocytes through a p38-MAPK pathway
- Increased Expression of Fibroblast Growth Factor 21 (FGF21) during Chronic Undernutrition Causes Growth Hormone Insensitivity in Chondrocytes by Inducing Leptin Receptor Overlapping Transcript (LEPROT) and Leptin Receptor Overlapping Transcript-like 1 (LEPROTL1) Expression
- Metabolic Hormone FGF21 Is Induced in Ground Squirrels during Hibernation but Its Overexpression Is Not Sufficient to Cause Torpor
- FGF21 Is an Insulin-Dependent Postprandial Hormone in Adult Humans
- Metabolic actions of FGF21: molecular mechanisms and therapeutic implications
- FGF21 functions as a sensitive biomarker of APAP-treated patients and mice
- Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses
- Peripherally derived FGF21 promotes remyelination in the central nervous system
- Dynamics and Distribution of Klothoβ (KLB) and Fibroblast Growth Factor Receptor-1 (FGFR1) in Living Cells Reveal the Fibroblast Growth Factor-21 (FGF21)-induced Receptor Complex
- [Optimization and characterization of a novel FGF21 mutant].
- FGF21 gene therapy as treatment for obesity and insulin resistance
- Pharmacokinetics (PK), Pharmacodynamics (PD) and Integrated PK/PD Modeling of a Novel Long Acting FGF21 Clinical Candidate PF-05231023 in Diet-Induced Obese and Leptin-Deficient Obese Mice
- Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints
- Role of PPAR in the Control of Torpor through FGF21-NPY Pathway: From Circadian Clock to Seasonal Change in Mammals
- A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response
- FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice
- A solid-phase PEGylation strategy for protein therapeutics using a potent FGF21 analog
- FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists
- FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats
- Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity
- Physiology and Endocrinology Symposium: FGF21: Insights into mechanism of action from preclinical studies
- Head Over Hepatocytes for FGF21
- Bone marrow mesenchymal stem cells: Fat on and blast off by FGF21
- FGF21 protein with enhanced binding affinity for β-Klotho for the treatment of type II diabetes, obesity, and related metabolic disorders
- Serum FGF21 and RBP4 levels in patients with chronic hepatitis C
- Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury
- FGF21 represses cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 signaling pathway in an AMPK-dependent manner
- Loss of FGF21 in diabetic mouse during hepatocellular carcinogenetic transformation
- The Protective Effect of FGF21 on Diabetes-Induced Male Germ Cell Apoptosis Is Associated With Up-Regulated Testicular AKT and AMPK/Sirt1/PGC-1α Signaling
- FGF21 Promotes Endothelial Cell Angiogenesis through a Dynamin-2 and Rab5 Dependent Pathway
- The cell adhesion molecule L1 regulates the expression of FGF21 and enhances neurite outgrowth
- Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/Sirt1 signaling in mice
- Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids
- FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice
- Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism Are Associated With Protein Ingestion–Induced Insulin Resistance
- Fgf21 analogues and derivatives
- Macronutrient Intake–Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial
- Photoperiodic regulation of FGF21 production in the Siberian hamster
- Fasting-Induced FGF21 Is Repressed by LXR Activation via Recruitment of an HDAC3 Corepressor Complex in Mice
- Methods of treating fgf21-associated disorders
- Research perspectives on the regulation and physiological functions of FGF21 and its association with NAFLD
- Selective Regulation of FGF19 and FGF21 Expression by Cellular and Nutritional Stress
- FGF21 in ataxia patients with spinocerebellar atrophy and mitochondrial disease
- Interplay between FGF21 and insulin action in the liver regulates metabolism
- PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates
- FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes
- The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice
- Adiponectin—a mediator of specific metabolic actions of FGF21
- FGF21 mutants comprising a mutation at position 98, 171 and/or 180
- FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis
- Chapter Two – The FGF21 Receptor Signaling Complex: Klothoβ, FGFR1c, and Other Regulatory Interactions
- GCN2 and FGF21 are likely mediators of the protection from cancer, autoimmunity, obesity, and diabetes afforded by vegan diets
- Long-term caloric restriction in ApoE-deficient mice results in neuroprotection via Fgf21-induced AMPK/mTOR pathway
- Commentary: FGF21 Holds Promises for Treating Obesity-related Insulin Resistance and Hepatosteatosis
- Low-protein diet induces, whereas high-protein diet reduces hepatic FGF21 production in mice, but glucose and not amino acids up-regulate FGF21 in cultured hepatocytes
- Brown Adipose Tissue and Browning Agents: Irisin and FGF21 in the Development of Obesity in Children and Adolescents
- Novel sandwich immunoassays for the measurement of total and active FGF21
- Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood
- Free Fatty Acids Impair FGF21 Action in HepG2 Cells
- Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency
- Rush to the fire: FGF21 extinguishes metabolic stress, metaflammation and tissue damage
- Fasting induces FGF21 in humans
- Upregulation of rat liver PPARα‐FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol
- Molecular Characterization and Mapping of Fgf21 Gene in a Foodfish Species Asian Seabass
- Plasma FGF21 levels in obese patients undergoing energy-restricted diets or bariatric surgery: a marker of metabolic stress?
- Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model
- FGF21 ameliorates the neurocontrol of blood pressure in the high fructose-drinking rats
- The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol
- Circulating FGF19 and FGF21 surge in early infancy from infra- to supra-adult concentrations
- FGF21 induced by carbon monoxide mediates metabolic homeostasis via the PERK/ATF4 pathway
- Cardiac Fgf21 synthesis and release: an autocrine loop for boosting up antioxidant defenses in failing hearts
- FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes
- Alterations in Hepatic FGF21, Co-Regulated Genes, and Upstream Metabolic Genes in Response to Nutrition, Ketosis and Inflammation in Peripartal Holstein Cows
- Fgf21 is required for cardiac remodeling in pregnancy
- A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure
- Hepatic FGF21 mediates sex differences in high-fat high-fructose diet-induced fatty liver
- Ampelopsin Improves Insulin Resistance by Activating PPARγ and Subsequently Up-Regulating FGF21–AMPK Signaling Pathway
- Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice
- Diet Polyphenol Curcumin Stimulates Hepatic Fgf21 Production and Restores Its Sensitivity in High-Fat-Diet–Fed Male Mice
- FGF21 Is a Hormonal Mediator of the Human “Thrifty” Metabolic Phenotype
- Circulating Fibroblast Growth Factor 21 (Fgf21) as Diagnostic and Prognostic Biomarker in Renal Cancer
- Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice
- FGF21 ameliorates diabetic cardiomyopathy by activating the AMPK-paraoxonase 1 signaling axis in mice
- The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-specific FGF21 Signaling
- Cholesterol Metabolism Altered and FGF21 Levels High After Pediatric Liver Transplantation Despite Normal Serum Lipids
- Hepatic FGF21 production is increased in late pregnancy in the mouse
- Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation
- Effects of insulin and exercise training on FGF21, its receptors and target genes in obesity and type 2 diabetes
- Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis
- A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys
- ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21.
- A low‐protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21)
- Metformin promotes cholesterol efflux in macrophages by up-regulating FGF21 expression: a novel anti-atherosclerotic mechanism
- FGF21 deficiency is associated with childhood obesity, insulin resistance and hypoadiponectinaemia: The BCAMS Study
- Two novel intronic polymorphisms of bovine FGF21 gene are associated with body weight at 18 months in Chinese cattle
- Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (G9a) and reduced FGF21 gene expression in Sprague–Dawley rats fed prenatal low protein and postnatal high-fat diets
- Homeostatic sensing of dietary protein restriction: A case for FGF21
- Suppression of Nrf2 attenuates adipogenesis and decreases FGF21 expression through PPAR gamma in 3T3-L1 cells
- Valproic Acid and Other HDAC Inhibitors Upregulate FGF21 Gene Expression and Promote Process Elongation in Glia by Inhibiting HDAC2 and 3
- Large-scale expression, purification, and glucose uptake activity of recombinant human FGF21 in Escherichia coli
- FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity
- Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy
- Defining “FGF21 Resistance” during obesity: Controversy, criteria and unresolved questions
- The Sum of All Browning in FGF21 Therapeutics
- FGF21 protects against ox-LDL induced apoptosis through suppressing CHOP expression in THP1 macrophage derived foam cells
- Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity
- Cord blood FGF21 in gestational diabetes and its relationship with postnatal growth
- Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects
- Relationship between FGF21 and UCP1 levels under time-restricted feeding and high-fat diet
- Association between insulin resistance and impairment of FGF21 signal transduction in skeletal muscles
- Fibroblast Growth Factor 21 (FGF21) Promotes Formation of Aerobic Myofibers via the FGF21‐SIRT1‐AMPK‐PGC1α Pathway
- Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-Fgf21 axis
- Changes in FGF21 Serum Concentrations and Liver mRNA Expression in an Experimental Model of Complete Lipodystrophy and Insulin-Resistant Diabetes
- Impact of FGF21 on glycemic control
- Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats undergoing catch-up growth
- Circulating CTRP1 Levels in Type 2 Diabetes and Their Association with FGF21
- The good, the bad, and the unknown: Fructose and FGF21
- Method of Treating or Ameliorating Type 1 Diabetes Using FGF21
- Balanced Coagonist of GLP-1 and Glucagon Receptors Corrects Dyslipidemia by Improving FGF21 Sensitivity in Hamster Model
- Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity
- FGF21 Protects the Blood–Brain Barrier by Upregulating PPARγ via FGFR1/β-klotho after Traumatic Brain Injury
- [Expression and pharmacological evaluation of fusion protein FGF21-L-Fc].
- FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest
- A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21
- FGF21drivesashiftinadipokinetonetorestoremetabolichealth
- FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1–7) Axis in Mice
- Fgf21 analogues and derivatives
- Pegbelfermin (BMS‐986036), PEGylated FGF21, in Patients with Obesity and Type 2 Diabetes: Results from a Randomized Phase 2 Study
- FGF21 Conducts a Metabolic Orchestra and Fat Is a Key Player
- Hepatic-specific PPARα-FGF21 action in NAFLD
- Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice
- FGF21 analogue shows promise in the clinic
- Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease
- Autophagic control of cardiac steatosis through FGF21 in obesity-associated cardiomyopathy
- TM-25659-Induced Activation of FGF21 Level Decreases Insulin Resistance and Inflammation in Skeletal Muscle via GCN2 Pathways
- Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals
- 1Identification of a domain within PPARγγγγ regulating expression of a group of genes containing FGF21 that are selectively repressed by SIRT1 in adipocytes.
- Treatment of CIA Mice with FGF21 Down-regulates TH17-IL-17 Axis
- Circulating FGF21 levels are related to nutritional status and metabolic but not hormonal disturbances in polycystic ovary syndrome
- FGF21 and DPP-4 inhibitor equally prevents cognitive decline in obese rats
- REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6
- Role of Fibroblast Growth Factor 21 (FGF21) in the Regulation of Statural Growth
- Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway
- Serum FGF21 Is Associated with Future Cardiovascular Events in Patients with Coronary Artery Disease
- FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency
- Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
- Pharmacological efficacy of FGF21 analogue, liraglutide and insulin glargine in treatment of type 2 diabetes
- FGF21 inhibits apolipoprotein(a) expression in HepG2 cells via the FGFR1-ERK1/2-Elk-1 pathway
- Roux-en-Y Gastric Bypass Surgery Has Unique Effects on Postprandial FGF21 but Not FGF19 Secretion
- Letter to the Editor: Parameters, Characteristics, and Criteria for Defining the Term “FGF21 Resistance”
- Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet
- An Overview of FGF19 and FGF21: The Therapeutic Role in the Treatment of the Metabolic Disorders and Obesity
- FAP finds FGF21 easy to digest
- α1-Adrenergic receptor downregulates hepatic FGF21 production and circulating FGF21 levels in mice
- FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys
- The regulation of FGF21 gene expression by metabolic factors and nutrients
- The Sweetest Thing: Regulation of Macronutrient Preference by FGF21
- A long‐acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non‐alcoholic steatohepatitis partly through an FGF21‐adiponectin‐IL17A pathway
- Shedding light on FGF21: A potential negative regulator of PCSK9
- Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance
- FGF21 attenuates pulmonary fibrogenesis through ameliorating oxidative stress in vivo and in vitro
- Effects of central fibroblast growth factor 21 (FGF21) in energy balance.
- Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21
- Expression and purification of FGF21 in Pichia pastoris and its effect on fibroblast-cell migration
- Fibroblast Growth Factor 21 (Fgf21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is Not Upregulated in the Liver of Mice Fed a High-Fat Obesogenic Diet
- Recombinant FGF21 Protects Against Blood-Brain Barrier Leakage Through Nrf2 Upregulation in Type 2 Diabetes Mice
- KLOTHO, FGF21 AND FGF23: NOVEL PATHWAYS TO MUSCULOSKELETAL HEALTH?
- Pharmacologic stimulation of central GLP-1 receptors has opposite effects on the alterations of plasma FGF21 levels induced by feeding and fasting
- FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice
- Serum FGF21 in boys with idiopathic short stature: relationship to lipid profile, onset of puberty and growth.
- BMS-986036 (pegylated FGF21) in patients with non-alcoholic steatohepatitis: a phase 2 study
- Is FGF23 or FGF21 a Promising Biomarker to Indicate the Aging Process in COPD?
- MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function
- The moderate essential amino acid restriction entailed by low-protein vegan diets may promote vascular health by stimulating FGF21 secretion
- Early increases in serum FGF21 levels predict mortality of septic patients
- The metabolic hormone FGF21 is associated with endothelial dysfunction in hemodialysis patients
- NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1
- A combined docosahexaenoic acid–thyroid hormone protocol upregulates rat liver β-Klotho expression and downstream components of FGF21 signaling as a potential novel approach to metabolic stress conditions
- High FGF21 levels are associated with altered bone homeostasis in HIV-1-infected patients
- Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction
- The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans
- Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21
- FGF21 inhibitor suppresses the proliferation and migration of human umbilical vein endothelial cells through the eNOS/PI3K/AKT pathway
- Metabolic messengers: FGF21
- Advances in biological functions and clinical studies of FGF21
- FGF21 in obesity and cancer: New insights
- A pyrexic effect of FGF21 independent of energy expenditure and UCP1
- FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes
- FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit
- Stress-induced FGF21 and GDF15 in obesity and obesity resistance
- FGF19 and FGF21: In NASH we trust
- The roles and pharmacological effects of FGF21 in preventing aging-associated metabolic diseases
- Hepatic hormone FGF21 and its analogues in clinical trials
- Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice
- Association between serum FGF21 level and sarcopenia in older adults
- FGF21 facilitates autophagy in prostate cancer cells by inhibiting the PI3K–Akt–mTOR signaling pathway
- Neuroprotective effects of the FGF21 analogue LY2405319
- Hepatic FGF21 preserves thermoregulation and cardiovascular function during bacterial inflammation
- A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21
- FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice
- Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis
- Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21
- The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model
- OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21
- Diagnostic value of serum biomarkers FGF21 and GDF15 compared to muscle sample in mitochondrial disease
- Hepatic P38 activation modulates systemic metabolism through FGF21-mediated interorgan communication
- FGF21 promotes non-small cell lung cancer progression by SIRT1/PI3K/AKT signaling
- Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and-independent mechanisms
- Central FGF21 production regulates memory but not peripheral metabolism
- Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response
- FGF21 prevents low-protein diet-induced renal inflammation in aged mice
- The same metabolic response to FGF21 administration in male and female obese mice is accompanied by sex-specific changes in adipose tissue gene expression
- Higher fasting plasma FGF21 concentration is associated with lower ad libitum soda consumption in humans
- Disease-specific plasma levels of mitokines FGF21, GDF15, and Humanin in type II diabetes and Alzheimer’s disease in comparison with healthy aging
- FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition
- Hepatic CPT1A Facilitates Liver–Adipose Cross Talk via Induction of FGF21 in Mice
- LLF580, an FGF21 analog, reduces triglycerides and hepatic fat in obese adults with modest hypertriglyceridemia
- FGF21 (Fibroblast Growth Factor 21) defines a potential cardiohepatic signaling circuit in end-stage heart failure
- FGF21 serum levels are related to insulin resistance, metabolic changes and obesity in Mexican people living with HIV (PLWH)
- FGF21 promotes migration and differentiation of epidermal cells during wound healing via SIRT1‐dependent autophagy
- Relationship between FGF21 and drug or nondrug therapy of type 2 diabetes mellitus
- Integration of FGF21 signaling and metabolomics in high-fat diet-induced obesity
- FGF21 induced by the ASK1-p38 pathway promotes mechanical cell competition by attracting cells
- FGF21/adiponectin ratio predicts deterioration in glycemia: a 4.6-year prospective study in China
- FGF21 ameliorates hepatic fibrosis by multiple mechanisms
- Ultrasound-assisted C3F8-filled PLGA nanobubbles for enhanced FGF21 delivery and improved prophylactic treatment of diabetic cardiomyopathy
- Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1
- Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure
- Dynamic folding modulation generates FGF21 variant against diabetes
- Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects
- FoxO1 suppresses FGF21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance
- FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction
- Association of plasma FGF21 levels with muscle mass and muscle strength in a national multicentre cohort study: Korean Frailty and Aging Cohort Study
- Bupleuri radix extract ameliorates impaired lipid metabolism in high-fat diet-induced obese mice via gut microbia-mediated regulation of FGF21 signaling …
- FGF21: A novel regulator of glucose and lipid metabolism and whole-body energy balance
- Pubertal FGF21 deficit is central in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome
- Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats
- Short‐term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue
- Sulforaphane Regulates Glucose and Lipid Metabolisms in Obese Mice by Restraining JNK and Activating Insulin and FGF21 Signal Pathways
- Phytochemicals from the cocoa shell modulate mitochondrial function, lipid and glucose metabolism in hepatocytes via activation of FGF21/ERK, AKT, and mTOR …
- Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway
- Serum levels of FGF21, β-klotho, and BDNF in stable coronary artery disease patients with depressive symptoms: a cross-sectional single-center study
- Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration
- Dietary Patterns and Their Associations With the FTO and FGF21 Gene Variants Among Emirati Adults
- Alginate self-adhesive hydrogel combined with dental pulp stem cells and FGF21 repairs hemisection spinal cord injury via apoptosis and autophagy …
- Mice with high FGF21 serum levels had a reduced preference for morphine and an attenuated development of acute antinociceptive tolerance and physical …
- Leptin, Acting at Central Level, Increases FGF21 Expression in White Adipose Tissue via PPARβ/δ
- FGF21 promotes ischaemic angiogenesis and endothelial progenitor cells function under diabetic conditions in an AMPK/NAD+‐dependent manner
- Ketone body and FGF21 coordinately regulate fasting-induced oxidative stress response in the heart
- FOXO1 inhibition synergizes with FGF21 to normalize glucose control in diabetic mice
- Preparation, characterization, and pharmacological study of a novel long-acting FGF21 with a potential therapeutic effect in obesity
- Ahnak deficiency attenuates high-fat diet-induced fatty liver in mice through FGF21 induction
- Plasma from healthy donors protects blood–brain barrier integrity via FGF21 and improves the recovery in a mouse model of cerebral ischaemia
- FGF21 attenuates high uric acid‑induced endoplasmic reticulum stress, inflammation and vascular endothelial cell dysfunction by activating Sirt1
- P7C3‐A20 alleviates fatty liver by shaping gut microbiota and inducing FGF21/FGF1, via the AMP‐activated protein kinase/CREB regulated transcription coactivator 2 …
- The miR-182-5p/FGF21/acetylcholine axis mediates the crosstalk between adipocytes and macrophages to promote beige fat thermogenesis
- Levels of β-klotho determine the thermogenic responsiveness of adipose tissues: Involvement of the autocrine action of FGF21
- Neural afferents as potential targets to ameliorate FGF21-mediated sympathoexcitation
- The role of FGF21 in the pathogenesis of cardiovascular disease
- Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling …
- Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity
- Long-term adjustment of hepatic lipid metabolism after chronic stress and the role of FGF21
- MiR-26b-5p regulates the preadipocyte differentiation by targeting FGF21 in goats
- Does FGF21 Mediate the Potential Decrease in Sweet Food Intake and Preference Following Bariatric Surgery?
- FGF21 enhances therapeutic efficacy and reduces side effects of dexamethasone in treatment of rheumatoid arthritis
- FGF21 Serum Levels in the Early Second Trimester Are Positively Correlated With the Risk of Subsequent Gestational Diabetes Mellitus: A Propensity …
- Behavioral, Hormonal, Inflammatory, and Metabolic Effects Associated with FGF21-Pathway Activation in an ALS Mouse Model
- FGF21: a promising therapeutic agent for alcoholic cardiomyopathy?†
- Evaluation of testicular glycogen storage, FGF21 and LDH expression and physiological parameters of sperm in hyperglycemic rats treated with …
- The relationship between sarcopenia detected in newly diagnosed colorectal cancer patients and FGF21, irisin and CRP levels
- FGF21 attenuates hypoxia‑induced dysfunction and inflammation in HPAECs via the microRNA‑27b‑mediated PPARγ pathway
- Pegbelfermin, a PEGylated FGF21 analogue, has pharmacology without bone toxicity after 1-year dosing in skeletally-mature monkeys
- FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk
- Suppressive Effect of Autocrine FGF21 on Autophagy-Deficient Hepatic Tumorigenesis
- Novel adipokines CTRP1, CTRP9, and FGF21 in pediatric type 1 and type 2 diabetes: a cross-sectional analysis
- A novel GLP-1 and FGF21 dual agonist has therapeutic potential for diabetes and non-alcoholic steatohepatitis
- FGF21 impedes peripheral myelin development by stimulating p38 MAPK/c‐Jun axis
- Bicistronic reporter mice for monitoring of FGF21 expression
- Nutritional Regulation of Hepatic FGF21 by Dietary Restriction of Methionine
- FGF21 response to sucrose is associated with BMI and dorsal striatal signaling in humans
- Impact of Acutely Increased Endogenous-and Exogenous Ketone Bodies on FGF21 Levels in Humans
- FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes
- Mesenchymal stem cells modified by FGF21 and GLP1 ameliorate lipid metabolism while reducing blood glucose in type 2 diabetic mice
- Protein-carbohydrate interaction effects on energy balance, FGF21, IGF-1, and hypothalamic gene expression in rats
- Dietary induction of obesity and insulin resistance is associated with changes in FGF21 DNA methylation in liver of mice
- Hepatic Hedgehog Signaling Participates in the Crosstalk between Liver and Adipose Tissue in Mice by Regulating FGF21
- Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice
- Brite Adipocyte FGF21 Attenuates Cardiac Ischemia/Reperfusion Injury in Rat Hearts by Modulating NRF2
- Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice
- Deficiency of Cathelicidin Attenuates High-Fat Diet Plus Alcohol-Induced Liver Injury through FGF21/Adiponectin Regulation
- Lycopene attenuates oxidative stress-induced hepatic dysfunction of insulin signal transduction: involvement of FGF21 and mitochondria
- Plasma Tsukushi Concentration Is Associated with High Levels of Insulin and FGF21 and Low Level of Total Cholesterol in a General Population without Medication
- Therapeutic effect and mechanism of combined use of FGF21 and insulin on diabetic nephropathy
- FGF21 alleviates acute liver injury by inducing the SIRT1‐autophagy signalling pathway
- Association of Elevated Plasma FGF21 and Activated FGF21 Signaling in Visceral White Adipose Tissue and Improved Insulin Sensitivity in Gestational …
- Effects of feeding frequency on growth performance, feed intake, metabolism and expression of FGF21 in grass carp (Ctenopharyngodon idellus)
- FGF21 outperforms GDF15 as a diagnostic biomarker of mitochondrial disease in children
- Plasma FGF21 concentrations and spontaneous self-selection of protein suggest that 15% protein in the diet may not be enough for male adult rats
- Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice
- The Roles of FGF21 and ALCAT1 in Aerobic Exercise-Induced Cardioprotection of Postmyocardial Infarction Mice
- Rats self-select a constant protein-to-carbohydrate ratio rather than a constant protein-to-energy ratio and have low plasma FGF21 concentrations
- FGF21 alleviates pulmonary hypertension by inhibiting mTORC1/EIF4EBP1 pathway via H19
- Genome-wide association study for circulating FGF21 in patients with alcohol use disorder: Molecular links between the SNHG16 locus and catecholamine …
- Sitagliptin reduces FAP-activity and increases intact FGF21 levels in patients with newly detected glucose abnormalities
- FGF21 regulates alcohol intake: New hopes on the rise for alcohol use disorder treatment?
- Changes in hepatic triglyceride content with the activation of ER stress and increased FGF21 secretion during pregnancy
- Combined Therapy with a CCR2/CCR5 Antagonist and FGF21 Analogue Synergizes in Ameliorating Steatohepatitis and Fibrosis
- Recombinant FGF21 Attenuates Polychlorinated Biphenyl-Induced NAFLD/NASH by Modulating Hepatic Lipocalin-2 Expression
- ZFP36L1 regulates FGF21 mRNA turnover and modulates alcoholic hepatic steatosis and inflammation in mice
- Neuroprotective Effect of Lentivirus-Mediated FGF21 Gene Delivery in Experimental Alzheimer’s Disease is Augmented when Concerted with Rapamycin
- Efruxifermin, a long‐acting Fc‐fusion FGF21 analogue, reduces body weight gain but does not increase sympathetic tone or urine volume in Sprague Dawley rats
- Aerobic exercise regulates FGF21 and NLRP3 inflammasome-mediated pyroptosis and inhibits atherosclerosis in mice
- Another Kid on the Block: Long-acting FGF21 Analogue to Treat Dyslipidemia and Fatty Liver
- Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis
- FGF21 normalizes plasma glucose in mouse models of type 1 diabetes and insulin receptor dysfunction
- FGF21 attenuates pulmonary arterial hypertension via downregulation of miR‐130, which targets PPARγ
- Liraglutide regulates lipid metabolism via FGF21-LKB1-AMPK-ACC1 pathway in white adipose tissues and macrophage of type 2 diabetic mice
- Single Nucleotide Polymorphisms in Close Proximity to the Fibroblast Growth Factor 21 (FGF21) Gene Found to Be Associated with Sugar Intake in a Swedish …
- Pyruvate Upregulates Hepatic FGF21 Expression by Activating PDE and Inhibiting cAMP–Epac–CREB Signaling Pathway
- Plasma FGF21 concentrations are regulated by glucose independently of insulin and GLP-1 in lean, healthy humans
- Associations of FGF21 and GDF15 with mitochondrial dysfunction in children living with perinatally-acquired HIV: A cross-sectional evaluation of pediatric …
- The effect of FGF21 and its genetic variants on food and drug cravings, adipokines and metabolic traits
- Dynamic effects of dietary protein restriction on body weights, food consumption, and protein preference in C57BL/6J and FGF21‐KO mice
- Association between FGF19, FGF21 and lipocalin-2, and diabetes progression in PCOS
- Attenuation of FGF21 signalling might aggravate the impairment of glucose homeostasis during the high sucrose diet induced transition from prediabetes to …
- Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARα/FGF21 Axis
- An FGF21-like gene from swamp eel (Monopterus albus): Recombinant expression and its potential roles in glucose and lipid homeostasis
- … SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21/CREB/PGC1α pathway
- FGF21 and chronic kidney disease
- Potential of Hibiscus sabdariffa Linn. in managing FGF21 resistance in diet‐induced‐obesity rats via miR‐34a regulation
- High baseline FGF21 levels are associated with poor glucose-lowering efficacy of exenatide in patients with type 2 diabetes
- Dimethyl itaconate attenuates palmitate-induced insulin resistance in skeletal muscle cells through the AMPK/FGF21/PPARδ-mediated suppression of inflammation
- FGF21 Reduces Lipid Accumulation in Bovine Hepatocytes by Enhancing Lipid Oxidation and Reducing Lipogenesis via AMPK Signaling
- TWIST2 inhibits EMT and induces oxidative stress in lung cancer cells by regulating the FGF21-mediated AMPK/mTOR pathway
- Elevated serum FGF21 predicts the major adverse cardiovascular events in STEMI patients after emergency percutaneous coronary intervention
- DPP-4 inhibitor induces FGF21 expression via sirtuin 1 signaling and improves myocardial energy metabolism
- Non-Alcoholic Steatohepatitis Severity Associates with FGF21 Level and Kidney Glucose Uptake
- … -Cas9-based genome-wide screening identified novel targets for treating sorafenib-resistant hepatocellular carcinoma: a cross-talk between FGF21 and the NRF2 …
- Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα‐FGF21 Axis
- SNAI1 is upregulated during muscle regeneration and represses FGF21 and ATF3 expression by directly binding their promoters
- Production of active human FGF21 using tobacco mosaic virus-based transient expression system
- Circulating FGF21 vs. Stress Markers in Girls during Childhood and Adolescence, and in Their Caregivers: Intriguing Inter-Relations between Overweight/Obesity …
- Increased fibroblast growth factor 21 (FGF21) concentration in early second trimester amniotic fluid and its association with fetal growth
- Epigallocatechin-3-gallate ameliorates hepatic damages by relieve FGF21 resistance and promotion of FGF21–AMPK pathway in mice fed a high fat diet
- Dietary Essential Amino Acid Restriction Promotes Hyperdipsia via Hepatic FGF21
- Refined-JinQi-JiangTang tablet ameliorates hypertension through activation of FGF21/FGFR1 axis in fructose-fed rats
- Non-Alcoholic Fatty Liver Disease in Long-Term Type 2 Diabetes: Role of rs738409 PNPLA3 and rs499765 FGF21 Polymorphisms and Serum Biomarkers
- Fibroblast Growth Factor 21 (FGF21) Administration Sex-Specifically Affects Blood Insulin Levels and Liver Steatosis in Obese Ay Mice
- FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes
- Visceral adipose tissue-directed FGF21 gene therapy improves metabolic and immune health in BTBR mice
- Alternate-day fasting alleviates high fat diet induced non-alcoholic fatty liver disease through controlling PPARα/FGF21 signaling
- Serum levels of the cold stress hormones FGF21 and GDF-15 after cardiac arrest in infants and children enrolled in single center therapeutic hypothermia clinical trials
- Alcoholic fatty liver is blunted by rFGF21 administration in mice lacking adipose FGFR1: The role of FGF21 in PPARα-mediated regulation of adipose tissue mass
- The role of increased FGF21 in VLDL-TAG secretion and thermogenic gene expression in mice under protein malnutrition
- Sustained reduction of triglyceride and LDL cholesterol from single administration of the novel long-acting FGF21 analogue 0499
- FGF21 alleviates chronic inflammatory injury in the aging process through modulating polarization of macrophages
- KLF4 downregulates FGF21 to activate inflammatory injury and oxidative stress of LPS‑induced ATDC5 cells via SIRT1/NF‑κB/p53 signaling
- Does an increase in serum FGF21 level predict 28-day mortality of critical patients with sepsis and ARDS?
- Changes and significance of serum FGF21 in children with primary nephrotic syndrome and chronic renal failure
- Reduced triglycerides and LDL cholesterol from once-weekly administration of the well-tolerated novel FGF21 analogue 0499
- The Regulation Mechanism of different hair types in Inner Mongolia Cashmere Goat based on PI3K-AKT Pathway and FGF21
- Estradiol-dependent and independent effects of FGF21 in obese female mice
- Fibroblast growth factor 21 (FGF21) is increased in MDD and interacts with body mass index (BMI) to affect depression trajectory
- β-Hydroxybutyrate upregulates FGF21 expression through inhibition of histone deacetylases in hepatocytes
- FGF21 promotes wound healing of rat brain microvascular endothelial cells through facilitating TNF-α-mediated VEGFA and ERK1/2 signaling pathway
- FGF21 has a sex-specific role in calorie-restriction-induced beiging of white adipose tissue in mice
- FGF21 improves LPS-induced pulmonary microvascular endothelial cell dysfunction and inflammatory response through SIRT1-mediated NF-κB deacetylation
- Autotaxin, PPARs, and FGF21: An Eye Opener for Progressive Liver Disease?
- Author Correction: Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
- FGF21 Counteracts Alcohol Intoxication by Activating Noradrenergic Neurons
- hsa_circ_0001955 Promotes Colorectal Cancer Progression by Regulating miR-583/FGF21 Axis
- Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77–FGF21 pathway
- Relationship between Serum FGF21 and vWF Expression and Carotid Atherosclerosis in Elderly Patients with Hypertension
- FGF21 defines a potential cardio-hepatic signaling circuit in human heart failure
- GATA2/FGF21 Axis Regulates the Effects of High Glucose on the Apoptosis, Autophagy and Oxidative Stress of Human Umbilical Vein Endothelial Cell via PI3K/AKT …
- Autocrine FGF21 signalling promotes beiging
- Elabela prevents angiotensin II-induced apoptosis and inflammation in rat aortic adventitial fibroblasts via the activation of FGF21–ACE2 signaling
- Circulating myokines IL-6, IL-15 and FGF21 response to training is altered by exercise type but not by menopause in women with obesity
- Cardiovascular autonomic reflex tests and serum FGF21 levels in overweight and normal-weight men and women
- Protein preference and elevated plasma FGF21 induced by dietary protein restriction is similar in both male and female mice
- Involvement of FGF21 in pulmonary fibrosis
- Serum FGF21 levels are altered with various factors including lifestyle behaviors
- How a metabolic hormone, FGF21 (fibroblast growth factor 21) impacts reproduction
- FGF21 Response Varies by Sugar Type and is Associated with Body Weight, Dietary Added Sugar, and Neural Signaling in Humans
- Increased Plasma FGF21 and Activated FGF21 Signaling in Adipose Tissue and Its Possible Association With Insulin Sensitivity in Specific GDM Subtype
- Brite Adipocyte FGF21 Attenuates Cardiac Ischemia/Reperfusion Injury in Rat Hearts by Modulating NRF2. Cells 2022, 11, 567
- Early warning for inactive ovaries based on liver function index, serum MDA, IL-6, FGF21 and ANGPTL8 in dairy cows
- Fibroblast growth factor 21 (FGF21) is a sensitive marker of osteoporosis in haemodialysis patients: a cross-sectional observational study
- Activating Effects of the Bioactive Compounds From Coffee By-Products on FGF21 Signaling Modulate Hepatic Mitochondrial Bioenergetics and Energy …
- Effect of aquatic training on serum Fetuin-A, ANGPTL4 and FGF21 levels in type 2 diabetic obese women
- Effect of Exercise Training on Serum FGF21 Level in Adults with Metabolic Disorders, A Meta-Analysis
- … -Transcriptome Sequencing Reveals CeRNA Regulatory Network of mRNAs, lncRNAs, miRNAs and circRNAs in Pulmonary Hypertension Treated with FGF21
- FGF21 Is a Potential Therapeutic for Morphine Preference and Dependence
- Correlation between Serum FGF21 Level and Diabetic Peripheral Neuropathy
- 115-LB: Liver-Derived FGF21 Mediates the Promoting Effect of Glucagon Receptor Antagonism on Beta-Cell Regeneration in Type 2 Diabetic Mice
- FGF21 Promotes Proliferation and Estradiol Synthesis in Porcine Granulosa Cells
- Virtual Reality Alleviates Post-Stroke Depression by Regulating FGF21
- Homocysteine-induced endoplasmic reticulum stress activates FGF21 via CREBH, resulting in browning and atrophy of white adipose tissue in Bhmt knockout mice
- Endogenous GDF15 and FGF21 additively alleviate hepatic steatosis and insulin resistance in obese mice.
- Population Pharmacokinetics (PK) and Pharmacodynamics (PD) of BIO89-100, a Novel GlycoPEGylated FGF21, in a Phase 1b/2a POC Study in Nonalcoholic …
- Obesity-resistance of UCP1-deficient mice associates with sustained FGF21 sensitivity in inguinal adipose tissue
- … 21 (FGF21) is increased in individuals with gestational diabetes mellitus (GDM) after 24 gestational weeks. However, it is unknown whether the increase in FGF21 …
- Pharmacokinetics of FGF21-164 fusion protein in mice using UHPLC-MS/MS method
- Effects of different exercise on liver lipid accumulation and FGF21 secretion in obese rats
- Association of Common Variants of FGF21 Gene Polymorphism Rs499765 and Rs838133 with Type 2 Diabetes Mellitus in Iraqi Population
- The effect of high Intensity Interval Training (HIIT) on adipsin, FGF21 and ABCA1 indices in obese men
- Design and characterization of a FGF1-FGF21 chimeric protein with increased stability and enhanced antidiabetic activities.
- Erratum. Hepatic CPT1A Facilitates Liver-Adipose Cross Talk via Induction of FGF21 in Mice. Diabetes 2022; 71: 31-42
- 144-OR: Adipose Modeling of FGF21 Signaling Mutations in a Severe Insulin Resistance Syndrome
- MiR-26b-5p Promotes Osteogenesis of Bone Mesenchymal Stem Cells via Suppressing FGF21
- The effect of special training exercise on FGF21 expression and FGFR-1 among CABG patients
- Multi-year participation in prolonged athletic training is associated with higher risk of chronic fatigue and abnormal serum FGF21 levels in professional athletes
- LLF580, an FGF21 Analog, Reduces Triglycerides and Hepatic Fat in obese persons with modestly elevated triglycerides: A 12 Week Randomized Double Blind …
- Abstract TP235: Delayed FGF21 Administration Improves Cerebrovascular Remodeling And White Matter Repair After Focal Stroke In Diabetic Mice
- FGF21 restores hippocampual mitochondrial dysfunction via enhancing Nrf2/HO-1 and AMPK/SirT1/PGC-1α signaling pathways to alleviate chronic …
- … Select Abstract: The Beneficial Effect of Fenofibrate on Diabetic Retinopathy Is Influenced by PPARA Genetic Variability and Is Mediated by an Increase in FGF21 …
- Effect of Eight Weeks of Aerobic Exercise with Ginger Supplementation on FGF21, Irisin and Insulin Resistance in Women with Type 2 Diabetes
- The Hepatokine FGF21 Increases the Human Spermatozoa Motility
- Homocysteine-induced endoplasmic reticulum stress activates FGF21 via CREBH, resulting in browning and atrophy of white adipose tissue in Bhmt knockout mice
- FGF21 Levels and Bone Mineral Density in Metabolically Healthy and Metabolically Unhealthy Obese Children
- The association between FGF21 and diabetic erectile dysfunction: Evidence from clinical and animal studies
- FGF21 is released during increased lipogenesisis state following rapid-onset radioiodine-induced hypothyroidism
- 1379-P: Combination of FGF21 and ß3-Adrenergic Treatment in Obese Mice
- FGF21 Promotes Senescence, Apoptosis, and Extracellular Matrix Degradation in Osteoarthritis via the AMPK Signaling Pathway
- 286-OR: FGF21 Decreases Hepatic Triglycerides in a Weight Loss-Independent but Sex-Dependent Manner
- Close association between lifestyle and circulating FGF21 levels: A systematic review and meta-analysis
- FGF21/FGFR1-β-KL Cascade in Cardiomyocytes Modulates Angiogenesis and Inflammation Under Metabolic Stress
- FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction John L Diener1, 2, Sarah Mowbray1, Waan-Jeng …
- Serum FGF21 Levels Predict the MACE in Patients With Myocardial Infarction After Coronary Artery Bypass Graft Surgery
- Multi-organ FGF21-FGFR1 signaling in metabolic health and disease
- Corrigendum to” Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance”[The Journal of Nutritional Biochemistry 57 (2018) …
- Circulating FGF21 and GDF15 as Biomarkers for Screening, Diagnosis, and Severity Assessment of Primary Mitochondrial Disorders in Children
- (+)-Dehydrovomifoliol Alleviates Oleic Acid-Induced Lipid Accumulation in HepG2 Cells via the PPARα–FGF21 Pathway
- The effect of 8 weeks of high-intensity interval training (HIIT) Tribulus terrestris supplementation on serum BDNF and FGF21 in obese women
- 212-LB: Therapeutic Effect of a Novel Long-Acting GLP-1/GCG/FGF21/Anticytokine Tetra-Specific Liver Microenvironment-Targeting Drug (OGB21502) in MCD …
- Maternal High-Fat Diet Alters the Characteristics of Astrocytes and Worsens the Outcome of Stroke in Rat Offspring, Which Improves After FGF21 …
- 211-LB: Antifibrotic Effect of a Novel Long-Acting GLP-1/GCG/FGF21/Anti-Cytokine Tetra-Specific Liver Microenvironment-Targeting Drug (OGB21502) in CCl4 …
- FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes
- Hepatic Stearoyl-CoA desaturase deficiency-mediated induction of the insulin-like growth factor-binding protein 1 requires FGF21.
- Examining the potential of Urolithins to induce hepatic Fibroblast Growth Factor 21 (FGF21) Expression and Release in High Fat Diet Induced Obesity
- 208-LB: Peripheral CB1 Inverse Agonism Improves Metabolism in DIO Mice Independent of Hepatic FGF21
- Understanding the physiology of FGF21
- Inventing new medicines: the FGF21 story
- The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
- FGF21 is an Akt-regulated myokine
- FGF21 Requires βklotho to Act In Vivo
- FGF21 and cardiac physiopathology
- Going back to the biology of FGF21: new insights
- The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
- PPARα is a key regulator of hepatic FGF21
- Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
- FGF21 reloaded: challenges of a rapidly growing field
- FGF21 as a stress hormone: the roles of FGF21 in stress adaptation and the treatment of metabolic diseases
- A dozen years of discovery: insights into the physiology and pharmacology of FGF21
- FGF21 as a hepatokine, adipokine, and myokine in metabolism and diseases
- Different roles of N‐and C‐termini in the functional activity of FGF21
- FGF21 is an endocrine signal of protein restriction
- Discrete aspects of FGF21 in vivo pharmacology do not require UCP1
- A new frontier in FGF21 biology
- FGF21-based pharmacotherapy–potential utility for metabolic disorders
- FGF21: a novel prospect for the treatment of metabolic diseases
- FGF21 regulates sweet and alcohol preference
- FGF21 revolutions: recent advances illuminating FGF21 biology and medicinal properties
- Thermogenic activation induces FGF21 expression and release in brown adipose tissue
- FGF21 as Modulator of Metabolism in Health and Disease
- Interplay between FGF21 and insulin action in the liver regulates metabolism
- Defining the nutritional and metabolic context of FGF21 using the geometric framework
- Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor?
- FGF21 and the late adaptive response to starvation in humans
- FGF21 regulates metabolism through adipose-dependent and-independent mechanisms
- Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice
- FGF21 N-and C-termini play different roles in receptor interaction and activation
- FGF21: a missing link in the biology of fasting
- Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease
- Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress
- Physiological and pharmacological roles of FGF21 in cardiovascular diseases
- The fasting polypeptide FGF21 can enter brain from blood
- FGF21 and the physiological regulation of macronutrient preference
- TNF-α represses β-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway
- Long-term cold adaptation does not require FGF21 or UCP1
- Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
- FGF21 regulates metabolism and circadian behavior by acting on the nervous system
- Acute exercise induces FGF21 expression in mice and in healthy humans
- Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
- Novel locus including FGF21 is associated with dietary macronutrient intake
- Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance
- Autophagy deficiency leads to protection from obesity and insulin resistance by inducing FGF21 as a mitokine
- Serum levels of the adipokine FGF21 depend on renal function
- Pharmacologic effects of FGF21 are independent of the “browning” of white adipose tissue
- The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARα activation in man
- FGF21 contributes to neuroendocrine control of female reproduction
- Targeting FGF21 for the treatment of nonalcoholic steatohepatitis
- FGF21 is an exocrine pancreas secretagogue
- Understanding the Physical Interactions in the FGF21/FGFR/β‐Klotho Complex: Structural Requirements and Implications in FGF21 Signaling
- Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity
- Fundamentals of FGF19 & FGF21 Action In Vitro and In Vivo
- FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders
- FGF21 is a sugar-induced hormone associated with sweet intake and preference in humans
- FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss
- Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21
- Fatty liver and FGF21 physiology
- FGF21 attenuates lipolysis in human adipocytes–a possible link to improved insulin sensitivity
- Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans
- FGF21 gene therapy as treatment for obesity and insulin resistance
- FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
- Serum FGF21 levels are associated with brown adipose tissue activity in humans
- Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex
- FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
- FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases
- Fructose ingestion acutely stimulates circulating FGF21 levels in humans
- FGF21 mediates the lipid metabolism response to amino acid starvation
- Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts
- The roles of FGF21 in atherosclerosis pathogenesis
- LY2405319, an engineered FGF21 variant, improves the metabolic status of diabetic monkeys
- FGF21 mimetic shows therapeutic promise
- Dynamic change of serum FGF21 levels in response to glucose challenge in human
- An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice
- FGF21 takes a fat bite
- FGF21 signals protein status to the brain and adaptively regulates food choice and metabolism
- The regulation of FGF21 gene expression by metabolic factors and nutrients
- Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21
- Rationale-based engineering of a potent long-acting FGF21 analog for the treatment of type 2 diabetes
- Stressed liver and muscle call on adipocytes with FGF21
- FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting
- Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding
- Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses
- Defining “FGF21 Resistance” during obesity: Controversy, criteria and unresolved questions
- Tissue-specific expression of βKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
- Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue
- FGF21 as an endocrine regulator in lipid metabolism: from molecular evolution to physiology and pathophysiology
- The FGF21–adiponectin axis in controlling energy and vascular homeostasis
- FGF21 promotes metabolic homeostasis via white adipose and leptin in mice
- FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver
- FGF21 as a therapeutic reagent
- Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects
- Serum FGF21 levels in adult m. 3243A> G carriers: clinical implications
- Glucocorticoids regulate the metabolic hormone FGF21 in a feed-forward loop
- Circulating FGF21 levels in human health and metabolic disease
- Hepatic FGF21 expression is induced at birth via PPARα in response to milk intake and contributes to thermogenic activation of neonatal brown fat
- Circulating FGF21 proteolytic processing mediated by fibroblast activation protein
- The role of FGF21 in type 1 diabetes and its complications
- A novel approach to improve the function of FGF21
- Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
- Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue
- A long-acting FGF21 molecule, PF-05231023, decreases body weight and improves lipid profile in non-human primates and type 2 diabetic subjects
- Plasma FGF21 is elevated by the intense lipid mobilization of lactation
- FGF21 is an insulin-dependent postprandial hormone in adult humans
- SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and-independent mechanisms
- Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine
- Circulating FGF21 levels are progressively increased from the early to end stages of chronic kidney diseases and are associated with renal function in …
- Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes
- FGF21: an emerging therapeutic target for non-alcoholic steatohepatitis and related metabolic diseases
- Liver derived FGF21 maintains core body temperature during acute cold exposure
- FGF21-mediated improvements in glucose clearance require uncoupling protein 1
- Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients
- Research perspectives on the regulation and physiological functions of FGF21 and its association with NAFLD
- Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys
- KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
- Nrf2 represses FGF21 during long-term high-fat diet–induced obesity in mice
- FGF21: The center of a transcriptional nexus in metabolic regulation
- FGF21 is a hormonal mediator of the human “thrifty” metabolic phenotype
- A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism
- Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
- FGF21 analogs of sustained action enabled by orthogonal biosynthesis demonstrate enhanced antidiabetic pharmacology in rodents
- Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
- Metabolic responses to dietary protein restriction require an increase in FGF21 that is delayed by the absence of GCN2
- Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21
- Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action
- FGF21 regulates hepatic metabolic pathways to improve steatosis and inflammation
- FGF21 lowers plasma triglycerides by accelerating lipoprotein catabolism in white and brown adipose tissues
- Leptin as a Potential Regulator of FGF21
- Metformin stimulates FGF21 expression in primary hepatocytes
- mTORC1 is a major regulatory node in the FGF21 signaling network in adipocytes
- PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis
- Effects of insulin and exercise training on FGF21, its receptors and target genes in obesity and type 2 diabetes
- Exercise alleviates obesity-induced metabolic dysfunction via enhancing FGF21 sensitivity in adipose tissues
- Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates
- FGF21 signals to glutamatergic neurons in the ventromedial hypothalamus to suppress carbohydrate intake
- Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB
- Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy
- ATF4-and CHOP-dependent induction of FGF21 through endoplasmic reticulum stress
- FGF21 is required for cardiac remodeling in pregnancy
- iNKT cells induce FGF21 for thermogenesis and are required for maximal weight loss in GLP1 therapy
- Dietary methionine restriction reduces inflammation independent of FGF21 action
- FGF21 Is Increased by Inflammatory Stimuli and Protects Leptin-Deficient ob/ob Mice from the Toxicity of Sepsis
- FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs
- FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process
- Metabolic actions of FGF21: molecular mechanisms and therapeutic implications
- FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism
- FGF21 mediates the thermogenic and insulin-sensitizing effects of dietary methionine restriction but not its effects on hepatic lipid metabolism
- Increased FGF21 plasma levels in humans with sepsis and SIRS
- The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway
- Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice
- A specific ChREBP and PPARα cross-talk is required for the glucose-mediated FGF21 response
- An overview of FGF19 and FGF21: the therapeutic role in the treatment of the metabolic disorders and obesity
- FGF19 and FGF21 for the treatment of NASH—two sides of the same coin? Differential and overlapping effects of FGF19 and FGF21 from mice to human
- Rush to the fire: FGF21 extinguishes metabolic stress, metaflammation and tissue damage
- Impaired mitochondrial fat oxidation induces FGF21 in muscle
- FGF21 increases water intake, urine output and blood pressure in rats
- Obesity is a fibroblast growth factor 21 (FGF21)-resistant state
- Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity
- Plasma FGF21 displays a circadian rhythm during a 72‐h fast in healthy female volunteers
- The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes
- Circadian expression of FGF21 is induced by PPARα activation in the mouse liver
- A long‐acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non‐alcoholic steatohepatitis partly through an FGF21‐adiponectin‐IL17A …
- FGF21 attenuates pulmonary fibrogenesis through ameliorating oxidative stress in vivo and in vitro
- Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints
- FGF21 acts as a negative regulator of bile acid synthesis
- FGF21 deficiency is associated with childhood obesity, insulin resistance and hypoadiponectinaemia: the BCAMS Study
- FGF19 subfamily members: FGF19 and FGF21
- Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation
- The FGF21 receptor signaling complex: Klothoβ, FGFR1c, and other regulatory interactions
- FGF21 protects myocardial ischemia-reperfusion injury through reduction of miR-145-mediated autophagy
- The hormone FGF21 stimulates water drinking in response to ketogenic diet and alcohol
- Serum FGF21 levels are increased in newly diagnosed type 2 diabetes with nonalcoholic fatty liver disease and associated with hsCRP levels independently
- High-level expression and purification of soluble recombinant FGF21 protein by SUMO fusion in Escherichia coli
- Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21
- FGF21 mediates mesenchymal stem cell senescence via regulation of mitochondrial dynamics
- Homeostatic sensing of dietary protein restriction: a case for FGF21
- Plasma FGF21 levels are increased in patients with hypothyroidism independently of lipid profile
- FGF21 response to critical illness: effect of blood glucose control and relation with cellular stress and survival
- Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody
- Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor α
- Hepatic insulin resistance and increased hepatic glucose production in mice lacking FGF21
- FGF21 ameliorates nonalcoholic fatty liver disease by inducing autophagy
- Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans
- Plasma FGF21 levels in obese patients undergoing energy-restricted diets or bariatric surgery: a marker of metabolic stress?
- Glucagon stimulates hepatic FGF21 secretion through a PKA-and EPAC-dependent posttranscriptional mechanism
- FGF21 is essential for haematopoiesis in zebrafish
- A high circulating FGF21 level as a prognostic marker in patients with acute myocardial infarction
- Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation
- Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease
- Peripherally derived FGF21 promotes remyelination in the central nervous system
- An engineered FGF21 variant, LY2405319, can prevent non-alcoholic steatohepatitis by enhancing hepatic mitochondrial function
- FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling
- Exercise-induced secretion of FGF21 and follistatin are blocked by pancreatic clamp and impaired in type 2 diabetes
- The autocrine role of FGF21 in cultured adipocytes
- Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase
- ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21
- FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue
- Liver fat but not other adiposity measures influence circulating FGF21 levels in healthy young adult twins
- parameters, characteristics, and criteria for defining the term “FGF21 resistance”
- FGF21 attenuates high-fat diet-induced cognitive impairment via metabolic regulation and anti-inflammation of obese mice
- FGF19, FGF21, and an FGFR1/β-Klotho-activating antibody act on the nervous system to regulate body weight and glycemia
- FGF21 conducts a metabolic orchestra and fat is a key player
- FGF19 and FGF21 serum concentrations in human obesity and type 2 diabetes behave differently after diet-or surgically-induced weight loss
- Ketogenic diet impairs FGF21 signaling and promotes differential inflammatory responses in the liver and white adipose tissue
- Impact of short-term high-fat feeding and insulin-stimulated FGF21 levels in subjects with low birth weight and controls
- FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes
- A liver-bone endocrine relay by IGFBP1 promotes osteoclastogenesis and mediates FGF21-induced bone resorption
- A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure
- Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution
- The FGF21-CCL11 axis mediates beiging of white adipose tissues by coupling sympathetic nervous system to type 2 immunity
- FGF21 prevents angiotensin II-induced hypertension and vascular dysfunction by activation of ACE2/angiotensin-(1–7) axis in mice
- Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression in HepG2 cell line
- FGF21 attenuates neurodegeneration through modulating neuroinflammation and oxidant-stress
- Distinct association of serum FGF21 or adiponectin levels with clinical parameters in patients with type 2 diabetes
- Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21
- Loss of FGF21 in diabetic mouse during hepatocellular carcinogenetic transformation
- Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease
- FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway
- FGF21, energy expenditure and weight loss–how much brown fat do you need?
- FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein
- Epigenetic modulation of FGF21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood
- FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway
- Impact of FGF21 on glycemic control
- High‐protein diet more effectively reduces hepatic fat than low‐protein diet despite lower autophagy and FGF21 levels
- Dietary betaine supplementation increases FGF21 levels to improve glucose homeostasis and reduce hepatic lipid accumulation in mice
- FGF21 signaling in glutamatergic neurons is required for weight loss associated with dietary protein dilution
- FGF21 administration suppresses retinal and choroidal neovascularization in mice
- Serum FGF21 is associated with future cardiovascular events in patients with coronary artery disease
- Fenofibrate increases cardiac autophagy via FGF21/SIRT1 and prevents fibrosis and inflammation in the hearts of Type 1 diabetic mice
- Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARα and FGF21 transcripts in vivo
- FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages
- Serum FGF21 levels in obese Korean children and adolescents
- A2A receptor activation attenuates hypertensive cardiac remodeling via promoting brown adipose tissue-derived FGF21
- FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis
- CREBH improves diet-induced obesity, insulin resistance, and metabolic disturbances by FGF21-dependent and FGF21-independent mechanisms
- FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance
- Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy
- Probiotic culture supernatant improves metabolic function through FGF21-adiponectin pathway in mice
- Up-regulation of Nrf2 is involved in FGF21-mediated fenofibrate protection against type 1 diabetic nephropathy
- FGF21 functions as a sensitive biomarker of APAP-treated patients and mice
- Central resistin/TLR4 impairs adiponectin signaling, contributing to insulin and FGF21 resistance
- Protective effect of FGF21 on type 1 diabetes-induced testicular apoptotic cell death probably via both mitochondrial-and endoplasmic reticulum stress-dependent …
- Serum FGF21 increases with hepatic fat accumulation in pediatric onset intestinal failure
- FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice [S]
- FGF21 underlies a hormetic response to metabolic stress in methylmalonic acidemia
- Autophagic control of cardiac steatosis through FGF21 in obesity-associated cardiomyopathy
- FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at …
- Lactate induces FGF21 expression in adipocytes through a p38-MAPK pathway
- CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis
- FGF21 protects dopaminergic neurons in Parkinson’s disease models via repression of Neuroinflammation
- Oncogenic KRAS reduces expression of FGF21 in acinar cells to promote pancreatic tumorigenesis in mice on a high-fat diet
- FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats
- Overexpression of β-klotho in adipose tissue sensitizes male mice to endogenous FGF21 and provides protection from diet-induced obesity
- Skeletal muscle increases FGF21 expression in mitochondrial disorders to compensate for energy metabolic insufficiency by activating the mTOR–YY1–PGC1α …
- Fasting decreases plasma FGF21 in obese subjects and the expression of FGF21 receptors in adipose tissue in both lean and obese subjects
- FGF21 ameliorates the neurocontrol of blood pressure in the high fructose-drinking rats
- FGF21 is not a major mediator for bone homeostasis or metabolic actions of PPARα and PPARγ agonists
- FGF21 protects the blood–brain barrier by upregulating PPARγ via FGFR1/β-klotho after traumatic brain injury
- Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control
- A novel Fc-FGF21 with improved resistance to proteolysis, increased affinity toward β-klotho, and enhanced efficacy in mice and cynomolgus monkeys
- Anti-inflammatory effects of exercise training in adipose tissue do not require FGF21
- Fibroblast growth factor (FGF21) protects mouse liver against D-galactose-induced oxidative stress and apoptosis via activating Nrf2 and PI3K/Akt pathways
- FGF21 and DPP-4 inhibitor equally prevents cognitive decline in obese rats
- Metformin prevents fatty liver and improves balance of white/brown adipose in an obesity mouse model by inducing FGF21
- FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival
- Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21
- Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin
- FGF21 protects against hypoxia injury through inducing HSP72 in cerebral microvascular endothelial cells
- The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-α agonist-induced amelioration of metabolic disorders in obese mice
- FGF21 alleviates hepatic endoplasmic reticulum stress under physiological conditions
- FGF21 and the second coming of PPARγ
- … diet induces, whereas high-protein diet reduces hepatic FGF21 production in mice, but glucose and not amino acids up-regulate FGF21 in cultured hepatocytes
- Hepatic FGF21 mediates sex differences in high-fat high-fructose diet-induced fatty liver
- The nuclear receptor Rev-erbα regulates adipose tissue-specific FGF21 signaling
- Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet
- HRD1‐ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination
- FGF21 induced by carbon monoxide mediates metabolic homeostasis via the PERK/ATF4 pathway
- Lack of FGF21 promotes NASH-HCC transition via hepatocyte-TLR4-IL-17A signaling
- Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis
- Tanycytes regulate lipid homeostasis by sensing free fatty acids and signaling to key hypothalamic neuronal populations via FGF21 secretion
- Activation of cardiac AMPK-FGF21 feed-forward loop in acute myocardial infarction: Role of adrenergic overdrive and lipolysis byproducts
- Association between insulin resistance and impairment of FGF21 signal transduction in skeletal muscles
- Treatment of CIA mice with FGF21 down-regulates TH17-IL-17 axis
- FGF10 and FGF21 as regulators in adipocyte development and metabolism
- FGF21 signalling pathway and metabolic traits–genetic association analysis
- … enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 …
- Pharmacokinetics and pharmacodynamics of PF‐05231023, a novel long‐acting FGF21 mimetic, in a first‐in‐human study
- Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding
- Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity
- Interactions between FGF21 and BMP-2 in osteogenesis
- FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice
- Time-imposed daily restricted feeding induces rhythmic expression of FGF21 in white adipose tissue of mice
- Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance
- Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients
- Baseline HOMA IR and circulating FGF21 levels predict NAFLD improvement in patients undergoing a low carbohydrate dietary intervention for weight loss: a …
- Long-term caloric restriction in ApoE-deficient mice results in neuroprotection via FGF21-induced AMPK/mTOR pathway
- Metformin ameliorates experimental-obesity-associated autoimmune arthritis by inducing FGF21 expression and brown adipocyte differentiation
- Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH
- Pegylated FGF21 rapidly normalizes insulin-stimulated glucose utilization in diet-induced insulin resistant mice
- Diet polyphenol curcumin stimulates hepatic FGF21 production and restores its sensitivity in high-fat-diet–fed male mice
- Long-acting FGF21 inhibits retinal vascular leakage in in vivo and in vitro models
- FGF21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet
- Physiology and Endocrinology Symposium: FGF21: Insights into mechanism of action from preclinical studies,
- Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice
- Altered GDF15 and FGF21 levels in response to strenuous exercise: a study in marathon runners
- FGF21 attenuates hypoxia‑induced dysfunction and apoptosis in HPAECs through alleviating endoplasmic reticulum stress
- Selective regulation of FGF19 and FGF21 expression by cellular and nutritional stress
- Hepatic posttranscriptional network comprised of CCR4–NOT deadenylase and FGF21 maintains systemic metabolic homeostasis
- FGF21 mimics a fasting-induced metabolic state and increases appetite in zebrafish
- Relationship between FGF21 and UCP1 levels under time-restricted feeding and high-fat diet
- Molecular Characterization and Mapping of FGF21 Gene in a Foodfish Species Asian Seabass
- Improved FGF21 sensitivity and restored FGF21 signaling pathway in high-fat diet/streptozotocin-induced diabetic rats after duodenal-jejunal bypass and …
- Targeted DNA demethylation of the FGF21 promoter by CRISPR/dCas9-mediated epigenome editing
- Fibroblast growth factor 21 (FGF21) promotes formation of aerobic myofibers via the FGF21‐SIRT1‐AMPK‐PGC1α pathway
- Early increases in serum FGF21 levels predict mortality of septic patients
- Head over hepatocytes for FGF21
- Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet …
- Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model
- Increased plasma FGF21 level as an early biomarker for insulin resistance and metabolic disturbance in obese insulin-resistant rats
- Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron–sulfur cluster depletion in human skeletal muscle
- Macronutrient Intake–Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The …
- Recombinant FGF21 protects against blood-brain barrier leakage through Nrf2 upregulation in type 2 diabetes mice
- FGF21 trafficking in intact human cells revealed by cryo-electron tomography with gold nanoparticles
- Increased serum level of FGF21 in gestational diabetes mellitus
- Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion
- FGF21 suppresses hepatic glucose production through the activation of atypical protein kinase Cι/λ
- FGF21 is induced in cisplatin nephrotoxicity to protect against kidney tubular cell injury
- FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys
- Free fatty acids impair FGF21 action in HepG2 cells
- Low-protein and methionine, high-starch diets increase energy intake and expenditure, increase FGF21, decrease IGF-1, and have little effect on adiposity in mice
- FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes
- GCN2 and FGF21 are likely mediators of the protection from cancer, autoimmunity, obesity, and diabetes afforded by vegan diets
- A solid-phase PEGylation strategy for protein therapeutics using a potent FGF21 analog
- FAP finds FGF21 easy to digest
- Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice
- FGF21 represses cerebrovascular aging via improving mitochondrial biogenesis and inhibiting p53 signaling pathway in an AMPK-dependent manner
- FGF21 promotes functional recovery after hypoxic-ischemic brain injury in neonatal rats by activating the PI3K/Akt signaling pathway via FGFR1/β-klotho
- Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21
- YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity
- FGF21 ameliorates diabetic cardiomyopathy by activating the AMPK-paraoxonase 1 signaling axis in mice
- FGF21 regulates insulin sensitivity following long-term chronic stress
- Membraneless reproducible MoS2 field-effect transistor biosensor for high sensitive and selective detection of FGF21
- Hepatic Crtc2 controls whole body energy metabolism via a miR-34a-FGF21 axis
- FGF21 induces autophagy‐mediated cholesterol efflux to inhibit atherogenesis via RACK1 up‐regulation
- FGF21-FGFR1 coordinates phospholipid homeostasis, lipid droplet function, and ER stress in obesity
- Mild cold exposure modulates fibroblast growth factor 21 (FGF21) diurnal rhythm in humans: relationship between FGF21 levels, lipolysis, and cold-induced …
- Acute hyperenergetic, high-fat feeding increases circulating FGF21, LECT2, and fetuin-A in healthy men
- Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects
- High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the Treating to New Targets [TNT] Study)
- Negative correlation between cerebrospinal fluid FGF21 levels and BDI scores in male Chinese subjects
- Long-acting hypoglycemic effects of PEGylated FGF21 and insulin glargine in mice with type 1 diabetes
- Heme-regulated eIF2α kinase modulates hepatic FGF21 and is activated by PPARβ/δ deficiency
- Contribution of serum FGF21 level to the identification of left ventricular systolic dysfunction and cardiac death
- Delayed recanalization at 3 days after permanent MCAO attenuates neuronal apoptosis through FGF21/FGFR1/PI3K/Caspase-3 pathway in rats
- High-fat diet and FGF21 cooperatively promote aerobic thermogenesis in mtDNA mutator mice
- … scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 …
- KLF15‐activating Twist2 ameliorated hepatic steatosis by inhibiting inflammation and improving mitochondrial dysfunction via NF‐κB‐FGF21 or SREBP1c‐FGF21 …
- Mutual promotion of FGF21 and PPARγ attenuates hypoxia-induced pulmonary hypertension
- The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1α signaling
- Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non‐alcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1α pathway
- Circulating FGF19 and FGF21 surge in early infancy from infra-to supra-adult concentrations
- The suitability of FGF21 and FGF23 as new biomarkers in endometrial cancer patients
- Exercise ameliorates the FGF21–adiponectin axis impairment in diet-induced obese mice
- The effect of eight weeks high intensity interval training (HIIT) on serum amounts of FGF21 and irisin in sedentary obese women
- Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis
- Elevated FGF21 leads to attenuated postnatal linear growth in preterm infants through GH resistance in chondrocytes
- Roux-en-Y gastric bypass surgery has unique effects on postprandial FGF21 but not FGF19 secretion
- Adiponectin—a mediator of specific metabolic actions of FGF21
- FGF21 increases cholesterol efflux by upregulating ABCA1 through the ERK1/2–PPARγ–LXRα pathway in THP1 macrophage-derived foam cells
- Cord blood FGF21 in gestational diabetes and its relationship with postnatal growth
- Alternate-day fasting alleviates diabetes-induced glycolipid metabolism disorders: roles of FGF21 and bile acids
- Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/Sirt1 signaling in mice
- The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans
- Recruitment of histone methyltransferase G9a mediates transcriptional repression of FGF21 gene by E4BP4 protein
- Hepatic FGF21 production is increased in late pregnancy in the mouse
- Brown adipose tissue and browning agents: irisin and FGF21 in the development of obesity in children and adolescents
- REV-ERBα regulates FGF21 expression in the liver via hepatic nuclear factor 6
- Pemafibrate prevents retinal pathological neovascularization by increasing FGF21 level in a murine oxygen-induced retinopathy model
- Inhibition of the ox-LDL-induced pyroptosis by FGF21 of human umbilical vein endothelial cells through the TET2-UQCRC1-ROS pathway
- Fibroblast growth factor 21 (FGF21) protects against high fat diet induced inflammation and islet hyperplasia in pancreas
- Bone marrow mesenchymal stem cells: fat on and blast off by FGF21
- FGF21 protects human umbilical vein endothelial cells against high glucose-induced apoptosis via PI3K/Akt/Fox3a signaling pathway
- Suppression of Nrf2 attenuates adipogenesis and decreases FGF21 expression through PPAR gamma in 3T3-L1 cells
- HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection
- … intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta …
- Serum FGF21 and RBP4 levels in patients with chronic hepatitis C
- Pharmacological efficacy of FGF21 analogue, liraglutide and insulin glargine in treatment of type 2 diabetes
- FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in …
- The effects of high intensity interval training on serum levels of FGF21 and insulin resistance in obese men
- Fibroblast growth factor 21 (FGF21) inhibits macrophage-mediated inflammation by activating Nrf2 and suppressing the NF-κB signaling pathway
- FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway
- Novel sandwich immunoassays for the measurement of total and active FGF21
- Increased leptin, decreased adiponectin and FGF21 concentrations in adolescent offspring of women with gestational diabetes
- Time‐restricted feeding alleviates cardiac dysfunction induced by simulated microgravity via restoring cardiac FGF21 signaling
- Valproic acid and other HDAC inhibitors upregulate FGF21 gene expression and promote process elongation in glia by inhibiting HDAC2 and 3
- Changes in plasma concentrations and mRNA expression of hepatokines fetuin A, fetuin B and FGF21 in physiological pregnancy and gestational diabetes …
- FGF21 reverses hepatic steatosis, increases energy expenditure and improves insulin sensitivity in diet-induced obese mice
- FGF21 is associated with metabolic effects and treatment response in depressed bipolar II disorder patients treated with valproate
- High FGF21 levels are associated with altered bone homeostasis in HIV-1-infected patients
- Exercise increases serum fibroblast growth factor 21 (FGF21) levels
- The cell adhesion molecule L1 regulates the expression of FGF21 and enhances neurite outgrowth
- Age‐related bone loss is associated with FGF21 but not IGFBP1 in healthy adults
- Commentary: FGF21 holds promises for treating obesity-related insulin resistance and hepatosteatosis
- A new FGF21 analog for the treatment of fatty liver disease
- Hepatic-specific PPARα-FGF21 action in NAFLD
- Effect of circulating glucagon and free fatty acids on hepatic FGF21 production in dairy cows
- Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway
- FGF21 protects against aggravated blood-brain barrier disruption after ischemic focal stroke in diabetic db/db male mice via cerebrovascular PPARγ activation
- Upregulation of rat liver PPARα‐FGF21 signaling by a docosahexaenoic acid and thyroid hormone combined protocol
- Optimization and characterization of a novel FGF21 mutant
- Interaction of glucocorticoids with FXR/FGF19/FGF21-mediated ileum-liver crosstalk
- Factors associated with cognitive impairment in elderly versus nonelderly patients with metabolic syndrome: the different roles of FGF21
- AKR-001, an Fc-FGF21 analog, showed sustained pharmacodynamic effects on insulin sensitivity and lipid metabolism in type 2 diabetes patients
- High-efficiency expression and secretion of human FGF21 in Bacillus subtilis by intercalation of a mini-cistron cassette and combinatorial optimization of cell …
- Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate
- Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet
- Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation
- Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via FGF21 induction
- Diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of PPARa and FGF21 in mice with hepatic ablation of brain-derived …
- Protein intake and amino acid supplementation regulate exercise recovery and performance through the modulation of mTOR, AMPK, FGF21, and immunity
- … of circulating exosomes derived from normal-weight and obese women on gluconeogenesis, glycogenesis, lipogenesis and secretion of FGF21 and fetuin A …
- Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals
- SIRT1 mediates effects of FGF21 to ameliorate cisplatin-induced acute kidney injury
- Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance
- Alterations in Hepatic FGF21, Co-Regulated Genes, and Upstream Metabolic Genes in Response to Nutrition, Ketosis and Inflammation in Peripartal Holstein …
- FGF21 in ataxia patients with spinocerebellar atrophy and mitochondrial disease
- Glyco-engineered long acting FGF21 variant with optimal pharmaceutical and pharmacokinetic properties to enable weekly to twice monthly subcutaneous …
- Activation of AK005401 aggravates acute ischemia/reperfusion mediated hippocampal injury by directly targeting YY1/FGF21
- Recombinant Lactococcus lactis NZ3900 expressing bioactive human FGF21 reduced body weight of Db/Db mice through the activity of brown adipose tissue
- Weight loss and concomitant adipose autophagy in methionine-restricted obese mice is not dependent on adiponectin or FGF21
- Whole transcriptome analysis and validation of metabolic pathways in subcutaneous adipose tissues during FGF21-induced weight loss in non-human …
- The sum of all browning in FGF21 therapeutics
- Sterol 12α-hydroxylase aggravates dyslipidemia by activating the ceramide/mTORC1/SREBP-1C pathway via FGF21 and FGF15
- Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation
- Cardiac FGF21 synthesis and release: an autocrine loop for boosting up antioxidant defenses in failing hearts
- Sex dimorphism in the FGF21 gene expression in liver and adipose tissues is dependent on the metabolic condition
- Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21
- TGF-β2, EGF, and FGF21 growth factors present in breast milk promote mesenteric lymph node lymphocytes maturation in suckling rats
- FGF21 decreases food intake and body weight in obese Göttingen minipigs
- Glucagon-dependent suppression of mTORC1 is associated with upregulation of hepatic FGF21 mRNA translation
- Ampelopsin improves insulin resistance by activating PPARγ and subsequently up-regulating FGF21-AMPK signaling pathway
- FGF21 exerts comparable pharmacological efficacy with Adalimumab in ameliorating collagen-induced rheumatoid arthritis by regulating systematic inflammatory …
- Srebp-1c/FGF21/Pgc-1α axis regulated by leptin signaling in adipocytes—possible mechanism of caloric restriction-associated metabolic remodeling of white adipose …
- Integrated Regulation of Hepatic Metabolism by Fibroblast Growth Factor 21 (FGF21) in Vivo
- Development of a long acting FGF21 analogue-albumin fusion protein and its anti-diabetic effects
- FGF21 protects against ox-LDL induced apoptosis through suppressing CHOP expression in THP1 macrophage derived foam cells
- FGF21 and glycemic control in patients with T1D
- FGF21 mediates the associations between exercise, ageing and glucose regulation
- The effect of two concurrent exercise modalities on serum concentrations of FGF21, irisin, follistatin, and myostatin in men with type 2 diabetes mellitus
- Insulin sensitizes FGF21 in glucose and lipid metabolisms via activating common AKT pathway
- Alteration in serum concentrations of FGF19, FGF21, and FGF23 in patients with urothelial carcinoma
- Reduced oxidative stress and enhanced FGF21 formation in livers of endurance-exercised rats with diet-induced NASH
- Alterations in 3-hydroxyisobutyrate and FGF21 metabolism are associated with protein ingestion–induced insulin resistance
- The effect of hydration status on plasma FGF21 concentrations in humans: A subanalysis of a randomised crossover trial
- FGF21 is dispensable for hypothermia induced by fasting in mice
- Role of PPAR in the control of torpor through FGF21-NPY pathway: from circadian clock to seasonal change in mammals
- Whey protein isolate inhibits hepatic FGF21 production, which precedes weight gain, hyperinsulinemia and hyperglycemia in mice fed a high-fat diet
- Metformin promotes cholesterol efflux in macrophages by up-regulating FGF21 expression: a novel anti-atherosclerotic mechanism
- Effects of central FGF21 infusion on the hypothalamus–pituitary–thyroid axis and energy metabolism in rats
- Fasting induces FGF21 in humans
- The metabolic hormone FGF21 is associated with endothelial dysfunction in hemodialysis patients
- Expression and purification of FGF21 in Pichia pastoris and its effect on fibroblast-cell migration
- Ethyl acetate extract of sappanwood alleviates experimental atherosclerosis in rats through changes in FGF21 and SREBP-2 expression
- Hypocaloric diet prevents the decrease in FGF21 elicited by high phosphorus intake
- Gene expression profiling reveals that PXR activation inhibits hepatic PPARα activity and decreases FGF21 secretion in male C57BL6/J mice
- … of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21
- Metabolic hormone FGF21 is induced in ground squirrels during hibernation but its overexpression is not sufficient to cause torpor
- FGF21 improves the adipocyte dysfunction related to seipin deficiency
- Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21
- FGF21 inhibitor suppresses the proliferation and migration of human umbilical vein endothelial cells through the eNOS/PI3K/AKT pathway
- Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice
- Ileal transposition surgery decreases fat mass and improves glucose metabolism in diabetic GK rats: possible involvement of FGF21
- Fibroblast growth factor 21 (FGF21) in human cerebrospinal fluid: relationship with plasma FGF21 and body adiposity
- Changes in FGF21 serum concentrations and liver mRNA expression in an experimental model of complete lipodystrophy and insulin-resistant diabetes
- Moderate-intensity continuous training improves FGF21 and KLB expression in obese mice
- Hepatic FGF21 expression is repressed after simvastatin treatment in mice
- High serum levels of FGF21 are decreased in bipolar mania patients during psychotropic medication treatment and are associated with increased metabolism …
- Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia
- Photoperiodic regulation of FGF21 production in the Siberian hamster
- Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury
- Mechanism for the effects of FGF21
- Hepatic STAMP2 mediates recombinant FGF21‐induced improvement of hepatic iron overload in nonalcoholic fatty liver disease
- Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity
- LPS infusion suppresses serum FGF21 levels in healthy adult volunteers
- Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster
- Expression and pharmacological evaluation of fusion protein FGF21-L-Fc
- Liver GCN2 controls hepatic FGF21 secretion and modulates whole body postprandial oxidation profile under a low-protein diet
- DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS‐induced FGF21
- Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats …
- Effects of EPA and lipoic acid supplementation on circulating FGF21 and the fatty acid profile in overweight/obese women following a hypocaloric diet
- Erratum. Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans. Diabetes 2008; 57: 1246–1253
- Parsing the potential neuroendocrine actions of FGF21 in primates
- Pegbelfermin (BMS‐986036), PEGylated FGF21, in patients with obesity and type 2 diabetes: results from a randomized phase 2 study
- FGF21 mediates the protective effect of fenofibrate against acetaminophen-induced hepatotoxicity via activating autophagy in mice
- Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 …
- PF-05231023, a long-acting FGF21 analogue, decreases body weight by reduction of food intake in non-human primates
- Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice
- Digenic variants in the FGF21 signaling pathway associated with severe insulin resistance and pseudoacromegaly
- Cholesterol metabolism altered and FGF21 levels high after pediatric liver transplantation despite normal serum lipids
- … of Klothoβ (KLB) and fibroblast growth factor receptor-1 (FGFR1) in living cells reveal the fibroblast growth factor-21 (FGF21)-induced receptor complex
- Enhanced expression and distinctive characterization of a long-acting FGF21 and its potential to alleviate nonalcoholic steatohepatitis
- Restoration of leptin responsiveness in diet‐induced obese mice using an optimized leptin analog in combination with exendin‐4 or FGF21
- The Influence of Hypertensive Therapies on Circulating Factors: Clinical Implications for SCFAs, FGF21, TNFSF14 and TNF-α
- Successful glycemic control decreases the elevated serum FGF21 level without affecting normal serum GDF15 levels in a patient with mitochondrial diabetes
- FGF21 knockout mice generated using CRISPR/Cas9 reveal genetic alterations that may affect hair growth
- Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (G9a) and reduced FGF21 gene expression in …
- Two novel intronic polymorphisms of bovine FGF21 gene are associated with body weight at 18 months in Chinese cattle
- Increased HO‐1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21
- An Exome-Chip Association Analysis in Chinese Subjects Reveals a Functional Missense Variant of GCKR That Regulates FGF21 Levels
- Characterization and quantification of an fc-FGF21 fusion protein in rat serum using immunoaffinity LC-MS
- Changes in selected biochemical parameters (including FGF21) during subclinical and clinical ketosis in dairy cows
- Large-scale expression, purification, and glucose uptake activity of recombinant human FGF21 in Escherichia coli
- Effects of beta-conglycinin intake on circulating FGF21 levels and brown adipose tissue activity in Japanese young men: a single intake study and a …
- … okamurae extract ameliorates the hyperglycemia and body weight gain of db/db mice through regulation of the PI3K/Akt pathway and thermogenic factors by FGF21
- Baseline circulating FGF21 concentrations and increase after fenofibrate treatment predict more rapid glycemic progression in type 2 diabetes: results from the FIELD …
- Fibroblast Growth Factor 21 (FGF21) and Glucagon-Like Peptide 1 Contribute to Diabetes Resistance in Glucagon Receptor–Deficient Mice
- Modulation of the systemic immune response in suckling rats by breast milk TGF-β2, EGF and FGF21 supplementation
- Uric acid induced hepatocytes lipid accumulation through regulation of miR-149-5p/FGF21 axis
- The sweetest thing: regulation of macronutrient preference by FGF21
- Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation
- FGF21 regulates melanogenesis in alpaca melanocytes via ERK1/2-mediated MITF downregulation
- Genetic variants flanking the FGF21 gene were associated with renal function in Chinese patients with type 2 diabetes
- FGF21 analogue shows promise in the clinic
- Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?
- The moderate essential amino acid restriction entailed by low-protein vegan diets may promote vascular health by stimulating FGF21 secretion
- Autofluorescence imaging of living pancreatic islets reveals fibroblast growth factor-21 (FGF21)-induced metabolism
- Role of fibroblast growth factor 21 (FGF21) in undernutrition-related attenuation of growth in mice
- Pharmacologic inhibition of serotonin htr2b ameliorates hyperglycemia and the altered expression of hepatic FGF21, Sdf2l1, and htr2a in db/db mice and …
- FGF21 is associated with Acanthosis nigricans in obese patients
- The role of fibroblast growth factor 21 (FGF21) on energy balance, glucose and lipid metabolism
- Lower cerebrospinal fluid/plasma fibroblast growth factor 21 (FGF21) ratios and placental FGF21 production in gestational diabetes
- Berberine-induced activation of AMPK increases hepatic FGF21 expression via NUR77
- Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
- … protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21)
- FGF21 regulates T-cell development in the neonatal and juvenile thymus
- miR-22 inhibition reduces hepatic steatosis via FGF21 and FGFR1 induction
- Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice
- Role of adipokines FGF21, leptin and adiponectin in self-concept of youths with obesity
- Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by inducing …
- Klotho, FGF21 and FGF23: novel pathways to musculoskeletal health?
- Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids
- Highly selective and sensitive measurement of active forms of FGF21 using novel immunocapture enrichment with LC–MS/MS
- Fasting insulin and alanine amino transferase, but not FGF21, were independent parameters related with irisin increment after intensive aerobic exercising
- Hepatic stearoyl CoA desaturase 1 deficiency increases glucose uptake in adipose tissue partially through the PGC-1α–FGF21 axis in mice
- Associations between FGF21, osteonectin and bone turnover markers in type 2 diabetic patients with albuminuria
- A tryptophan hydroxylase inhibitor decreases hepatic FGF21 expression and circulating FGF21 in mice fed a high-fat diet
- FGF21 and its Relationship with Inflammatory and Metabolic Parameters in HIV Patients after Antiretroviral Treatment
- Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21
- Hepatic FGF21 mediates tissue tolerance during bacterial inflammation by preserving cardiac function
- Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice
- Therapeutic approaches to Alzheimer’s type of dementia: a focus on FGF21 mediated neuroprotection
- Mediterranean Tomato‐Based Sofrito Sauce Improves Fibroblast Growth Factor 21 (FGF21) Signaling in White Adipose Tissue of Obese ZUCKER Rats
- In pursuit of a biomarker of weight gain susceptibility—is FGF21 a candidate?
- Metabolic responses to 24-hour fasting and mild cold exposure in overweight individuals are correlated and accompanied by changes in FGF21 concentration
- Effects of central fibroblast growth factor 21 (FGF21) in energy balance.
- Changes in liver gene expression and plasma concentration of Rbp4, Fetuin-A, and FGF21 in sprague-dawley rats subjected to different dietary interventions …
- α1-Adrenergic receptor downregulates hepatic FGF21 production and circulating FGF21 levels in mice
- FGF21 inhibits apolipoprotein (a) expression in HepG2 cells via the FGFR1-ERK1/2-Elk-1 pathway
- FGF21-protection against fructose-induced lipid accretion and oxidative stress is influenced by maternal nutrition in male progeny
- Circulating fibroblast growth factor 21 (FGF21) as diagnostic and prognostic biomarker in renal cancer
- Pulse wave velocity is associated with increased plasma oxLDL in ageing but not with FGF21 and habitual exercise
- Fibroblast growth factor-21 (FGF21) administration to early-lactating dairy cows. I. Effects on signaling and indices of insulin action
- Mapping the response of human fibroblast growth factor 21 (FGF21) promoter to serum availability and lipoic acid in HepG2 hepatoma cells
- FGF21 drives a shift in adipokine tone to restore metabolic health
- … cyanidin-3-glucoside attenuates high-fat-diet–induced body-weight gain and impairment of glucose tolerance in mice via effects on the hepatic hormone FGF21
- Therapeutic potential of FGF21 in diabetes
- A combined docosahexaenoic acid–thyroid hormone protocol upregulates rat liver β-Klotho expression and downstream components of FGF21 signaling as a …
- Maresin 1 regulates hepatic FGF21 in diet‐induced obese mice and in cultured hepatocytes
- Fibroblast growth factor 21 (FGF21) in children and adolescents with chronic kidney disease
- Balanced coagonist of GLP-1 and glucagon receptors corrects dyslipidemia by improving FGF21 sensitivity in hamster model
- The effect of vigorous aerobic exercise on serum levels of SIRT1, FGF21 and Fetuin A in women with type Ⅱ diabetes
- The swinging pendulum of biomarkers in mitochondrial disease: the role of FGF21
- Roles of FGF21 and irisin in obesity-related diabetes and pancreatic diseases
- The effect of high intensity interval training on serum levels of FGF21, insulin resistance and lipid profile in sedentary obese women
- Fibroblast Growth Factor 21 (FGF21) Gene Expression Is Elevated in the Liver of Mice Fed a High-Carbohydrate Liquid Diet and Attenuated by a Lipid Emulsion but Is …
- TCF4/β‑catenin complex is directly upstream of FGF21 in mouse stomach cancer cells
- Therapeutic role of fibroblast growth factor 21 (FGF21) in the amelioration of chronic diseases
- Predictive value of combined serum FGF21 and free t3 for survival in septic patients
- NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1
- Physiological and transcriptome analyses of transgenic FGF21 immature Rice seeds
- A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure
- Lipodystrophy HIV-related and FGF21: A new marker to follow the progression of lipodystrophy?
- Circulating CTRP1 levels in type 2 diabetes and their association with FGF21
- Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals
- Serum FGF21 in boys with idiopathic short stature: relationship to lipid profile, onset of puberty and growth
- Fibroblast growth factor-21 (FGF21) administration to early-lactating dairy cows. II. Pharmacokinetics, whole-animal performance, and lipid metabolism
- TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP–ATF response elements in the FGF21 promoter
- Thyroid hormone-induced expression of the hepatic scaffold proteins Sestrin2, β-Klotho, and FRS2α in relation to FGF21-AMPK signaling
- Cloning of goat FGF21 gene and its expression pattern in intramuscular adipocyte.
- Corrigendum to “ATF4-and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress”
- Is FGF23 or FGF21 a promising biomarker to indicate the aging process in COPD?
- FGF21 activation-mediated islet autophagy in Type 2 diabetes with pharmacotherapeutic potential
- Pharmacologic stimulation of central GLP-1 receptors has opposite effects on the alterations of plasma FGF21 levels induced by feeding and fasting
- TM-25659-induced activation of FGF21 level decreases insulin resistance and inflammation in skeletal muscle via GCN2 pathways
- FGF21 levels in pheochromocytoma/functional paraganglioma
- Moxibustion-simulating bipolar radiofrequency suppresses weight gain and induces adipose tissue browning via activation of UCP1 and FGF21 in a mouse …
- Serum levels of FGF21 and prediction of cardiovascular events
- FGF21, not GCN2, influences bone morphology due to dietary protein restrictions
- The good, the bad, and the unknown: Fructose and FGF21
- Relationship between Circulating FGF21 Concentrations and the Severity of Coronary Artery Damage in Subjects with Cardiovascular Disease
- Practical prospects for boosting hepatic production of the “pro-longevity” hormone FGF21
- Oral bezafibrate induces daily torpor and FGF21 in mice in a PPAR alpha dependent manner
- MS-275 induces hepatic FGF21 expression via H3K18ac-mediated CREBH signal
- Are you thirsty? FGF21 might be involved in that too
- Are Circulating FGF21 and NT-proBNP promising novel biomarkers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?
- FGF21—the cause of having a’sweet tooth’?
- Higher increase degree of FGF21 post long-term interdisciplinary weight loss therapy preserves the free fat mass and rest metabolic rate in adolescents with …
- The Metabolic Effects of FGF21: From Physiology to Pharmacology
- FGF21 ACEs hypertension
- Study on the kidney impairment and expressions of FGF21 from a rat model of vascular calcification
- Plasma FGF21 levels in rats are dependent on dietary proteins but not on dietary carbohydrates or fats
- Mice lacking neutral amino acid transporter B⁰AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control
- IGFBP1—hepatokine and target for FGF21-mediated bone loss
- Levels of Fibroblast Growth Factor 21 (FGF21) in serum as diagnostic biomarker in patients with breast cancer
- Role of fibroblast growth factor 21 (FGF21) in the regulation of statural growth
- 1060-P: The Effect of FGF21/GLP-1 Fusion Protein on Glucose and Lipid Metabolism Using Diabetic Mice Models
- Comment on serum FGF21 and RBP4 levels in patients with chronic hepatitis C
- The effect of 8 weeks of aerobic exercise on serum levels of FGF21, Apolipoprotein A-1 and LDL-C to HDL-C ratio in obese women
- Methionine Restriction Alleviates Aging-related Cognitive Dysfunction via Stimulating FGF21-driven Mitochondrial Biogenesis (P14-026-19)
- The Role of FGF21 in Pancreatic Islet Metabolism
- Capparis spinosa improves the high fat diet-induced non-alcoholic steatohepatitis in rats: the possible role of FGF21
- The Effect of Eight Weeks of High Intensity Interval Training (HIIT) on Serum Irisin, FGF21 and Glycemic Indices in Type 2 Diabetic Women
- Comment on “FGF21 Response to Critical Illness: Effect of Blood Glucose Control and Relation With Cellular Stress and Survival” by Thiessen SE, et al
- Potential role for FGF21 as a mediator of thyroid hormone effects on metabolic regulation
- Divergent Metabolic and Cardiovascular Effects of FGF21
- Increase in FGF21 stimulates browning markers in white adipose tissue in rats fed a low protein high carbohydrate diet during acute cold exposure
- Link between FGF21 and blood pressure
- FGF21 inhibits lipid accumulation and inflammation induced by palmitate in human hepatocytes via SIRT1 pathway
- Effects of ethinylestradiol-cyproterone acetate vs. pioglitazone-flutamide-metformin on plasma FGF21 levels in adolescent girls with androgen excess
- Therapeutic Potential of FGF21 in Alzheimer’s Disease
- Evaluation of a cell model expressing βKlotho for screening FGF21 analogues
- PEG-FGF21 variant improves hepatic steatosis in a mouse model of NASH as determined by quantitative water-fat MRI
- Association of the 3′ UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity
- FGF21 levels in patients with breast cancer
- FGF21 inhibits adiponectin secretion in human adipocytes
- Pancreatitis: a loss of FGF21 function disease with potential for correction
- Effects of eight-week resistance training on serum level of βKlotho and FGF21 in diabetic women with non-alcoholic fatty liver disease
- A tryptophan hydroxylase inhibitor increases hepatic FGF21 production and decreases hepatic gluconeogenesis independently of insulin in db/db mice
- Astaxanthin Attenuates Hepatic Damages and Mitochondrial Dysfunction in Nonalcoholic Fatty Liver Disease by Regulating the FGF21/PGC-1α Pathway
- Key role for FGF21 in GLP1-mediated weight loss
- Mechanisms of action of methionine restriction and fibroblast growth factor 21 (FGF21)
- OR01-3 microRNA-34a-mediated FGF21 resistance in the adipose tissue contributes to insulin resistance and hypoadiponectinemia in diet-induced obesity
- Hepatic FGF21 is Under the Regulation of the Canonical Wnt Signaling Pathway
- The Role of FGF21 in Regulating Lipid and Glucose Metabolism
- Identification of a crucial amino acid responsible for the loss of specifying FGFR1–KLB affinity of the iodinated FGF21
- The Potential of Hibiscus sabdariffa Linn. for Treatment of Obesity: Focus on FGF21 in Liver and Adipose Tissue
- The Effect of Resistance Training with High and Moderate Intensities on Lipid Profile, Glycemic Index and FGF21 in Type 2 Diabetic Patients
- 370-OR: Hepatic FGF21 Expression Is Under the Regulation of the Canonical Wnt Signaling Pathway
- FGF21 determined angiogenic phenotypes in pulmonary endothelial cells
- P612 Involvement of the cardiomyokine FGF21 in protection against oxidative stress damage in the heart.
- The role of hepatic FGF21 (Fibroblast Growth Factor 21) in the maintenance of metabolic homeostasis during metabolic stress
- FGF21 action on human adipose tissue compromised by reduced βKlotho and FGFR1 expression in type 2 diabetes mellitus
- FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages
- Defective autophagy causes a maladaptive cardiac phenotype to exercise that leads to premature death and FGF21‐mediated protection against obesity and insulin …
- Protective Role of FGF21 in Adverse Cardiac Remodeling After Myocardial Infarction
- Effect of EPO on PRDM16, FGF21 expression and STAT phosphorylation of brown adipose tissue in HFD mice
- SREBP-1c knockdown attenuated fatty degeneration in hepatic L02 cells and inhibited CCL2 and FGF21 protein expression
- Positive correlations between and prediction of FGF21, adiponectin, leptin and NPY concentrations in the cerebrospinal fluid of Chinese subjects using back …
- GW29-e1353 A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21
- Construction of FGF21 knockout mouse models by the CRISPR/Cas9 system.
- Lack of FGF21 accelerates NASH-HCC transition via up-regulation of hepatic SPHK1-S1P-HIPPO signaling in murine models
- DOCTORAL DISSERTATION Translational Aspects of FGF21
- FGF21 and its Relationship with Inflammatory and Metabolic Parameters in HIV Patients after Antiretroviral Treatment
- Cloning and Expression Analysis of FGF21 Gene in Ctenopharyngodon idellus
- Restoring FGF21 reverses pancreatitis.
- Mechanisms and dynamics of mitochondrial disease stress responses: special emphasis on FGF21
- Altered FGF21 response in alcohol induced “Acute-on-chronic liver injury”(ACLI) model
- Expression, purification and characterization of recombinant canine FGF21 in Escherichia coli
- Therapeutic potential of FGF21 in cardiorenal syndrome
- Dietary protein and age-dependent female fertility: FGF21 trumps mTORC1
- The effects of eight weeks of resistance training on serum levels of FGF21, LCAT and LDL-C to HDL-C ratio in obese women
- Role of FGF21 and GCN2 in mediating the metabolic response to dietary protein restriction
- FGF21 Coordinates Adiponectin to Mediate the Beneficial Effects of Low-Protein Diet on Primordial Follicle Reserve
- Fibroblast Growth Factor 21 (FGF21) creates sugar-specific taste aversion to fructose through action in the brain in mice
- Effect of FGF21 on short-term white adipocyte adiponectin secretion
- An investigation of acute exercise and FGF21.
- The Liver-Derived Endocrine Hormone FGF21 Alters Metabolism and Diurnal Behavior via the Nervous System
- FGF21 prevents high fat diet-induced pancreatic cancer in mice expressing oncogenic Kras
- Regulation of the organokines FGF21 and chemerin by diet: metabolic and molecular effects in liver and adipose tissue of obese human subjects
- P1499 FGF21 CORRELATES POSITIVELY WITH ARTERIOVENOUS FISTULA OCCLUSION IN HEMODIALYSIS PATIENTS
- STUDIES ON THE REGULATION OF FGF21 GENE EXPRESSION BY (R)-α-LIPOIC ACID: MECHANISTIC INSIGHT INTO THE LIPID LOWERING PROPERTIES OF A …
- A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling Via Promoting Brown Adipose Tissue-Derived FGF21
- A Polymorphism in the FGF21 Gene is a Novel Risk Variant for Metabolic-Associated Steatohepatitis
- Expression of FGF21 and receptors FGFR1, FGFR2 in the first hair follicle growth cycle of mice.
- Association of FGF19, FGF21 and FGF23 with carbohydrate metabolism parameters and insulin resistance in patients with chronic kidney disease.
- FGF21 mediates corticosteroid-related bone mass loss through PPAR-
- O29: Régulation circadienne et nutritionnelle de FGF21 par PPARalpha
- Altered GDF15 and FGF21 Levels in Response to Strenuous Exercise: A Study in Marathon Runners
- Elevated FGF21 during insufficient sleep in active but not sedentary volunteers
- The secret life of FGF21
- FGF21 mediates the anti-depressant effects of exercise by coordinating the crosstalk between central and peripheral organs
- FGF21—central pathways of action unravelled
- Mistranslation drives alterations in protein levels and the effects of a synonymous variant at the FGF21 locus
- Factor-Associated Risk Factors of Mild Cognitive Impairment in Thalassemia Patients: Probable Role of FGF21
- Lack of FGF21 promotes NASH-HCC transition via exosome-mediated carcinogenetic signaling
- Fibroblast growth factor 21 (FGF21) in hyper-and hypothyroidism, association with metabolic disturbances
- FGF21: un lien entre reproduction et métabolisme
- FGF21 Expresses in Diabetic Hearts and Protects from Palmitate- and Diabetes-Induced Cardiac Cell Death In Vitro and In Vivo Via Erk1/2-Dependent P38 Mapk …
- FGF21 Prospects for Applications in Clinical Practice
- FGF21 restores photoreceptor function in type 1 diabetic mice
- FGF21: How sweet it is!
- mAb about FGF21
- Microglia-derived FGF21 as a modulator of astrocytic phenotype and cerebral ischemia injury
- Adipose and nonadipose effects of FGF21 delineated
- FGF21 as a Biomarker for Metabolic Stress in Heart Failure
- Effect of Moderate Aerobic Exercise on Serum Levels of FGF21 and Fetuin A in Women with Type 2 Diabetes
- The Physiology and Pharmacology of FGF21 in the Exocrine Pancreas
- The Consequences of LP Diet on Food Intake, Energy Expenditure and Hepatic and Hypothalamic FGF21 Are Reproduced by lLsine or Threonine Deficiency in Rats
- FGF21 action in the fat
- BIO89-100, a novel glycoPEGylated FGF21 Analog, Demonstrates Triglyceride Reduction and Broad Metabolic Effects in Spontaneously Diabetic Obese Cynomolgus …
- Correction for: Activation of AK005401 aggravates acute ischemia/reperfusion mediated hippocampal injury by directly targeting YY1/FGF21
- Ontogeny of FGF21 in the Human: Implications for Metabolic Health
- FGF21: A biomarker of neuromuscular diseases
- Regulation of glucose homeostasis by FGF21
- Comparison of Resistance, Aerobic and Combined Trainings Effects on the FGF21 Serum Levels in Active Elderly Men
- Regulation of Glucose Homeostasis by FGF21
- P3478 Glucose-dependent insulinotropic peptide is essential for maintenance of cardiac lipid metabolism via FGF21-dependent pathway
- Lack of FGF21 accelerates the Th17-IL-17 axis-mediated transition from nonalcoholic steatohepatitis to hepatocellular carcinoma
- The therapeutic effects of FGF21 on diabetic nephropathy are realized by augmenting autophagy via AMPK/mTOR signaling pathway
- FGF21 in acute and chronic alcohol consumption
- Fibroblast growth factor 21 (FGF21), free fatty acid (FFA), high sensitivity C-reactive protein (hsCRP) and homeostasis model assessment of insulin resistance (HOMA …
- FGF21 gets the juices flowing
- FGF21 prevented diabetic renal fibrosis
- Effect and mechanism of FGF21 on astrocyte damage induced by Aβ25-35
- FGF21 influences a’sweet tooth’in mice
- FGF21: starvation hormone to a clinical drug?
- 282-LB: Dysregulated FGF21 Links Hepatic Insulin Resistance to Dysfunctional BAT
- FGF21 Attenuates Neurodegeneration though Reducing Neuroinflammation and Oxidant-stress
- Mechanism of metabolic surgery mediated FGF21 in improving insulin resistance
- Glucagon Regulates Energy Balance via FGF21 Signaling in the Brain
- Pharmacological effects of recombinant FGF21 in ovariectomized mice C57Bl/6J
- The role of FGF21 in regulating energy homeostasis
- PPARα is a Key regulator of Hepatic FGF21 PPAR is a Key regulator of Hepatic FGF21
- Correlations between serum FGF21 and IRISIN levels and nutritional, biochemical, and anthropometric parameters in non-alcoholic fatty liver disease
- Expression of recombinant h-FGF21 in periplasmic space of Escherichia coli
- P rocess development of a FGF21 protein–antibody conjugate
- Regulation of FGF21 Gene Expression by Nutritional Signals and Physical Activity in vivo and in vitro
- Low protein/low methionine/high carbohydrate diets induce hyperphagia, increase energy expenditure and FGF21, but modestly affect adiposity in female BalbC mice.
- The physiology and pharmacology of the fasting-induced hormone, FGF21
- FGF21 improves glucose homeostasis in diabetes-prone NZO mice
- FGF21 in NASH and Liver Fibrosis
- Going hedonic-the role of FGF21 in the preference for sweet and alcohol
- FGF21 prevented diabetic renal fibrosis
- Mesenchymal Stem Cells Overexpressing FGF21 Improve Functional Recovery After Traumatic Brain Injury
- BIO89-100, a Novel Glycopegylated FGF21 Analogue, Demonstrates Robust Reduction in Serum Lipids and Long Half-life in a Phase 1 Randomized …
- Serum FGF21 Levels in Obese Korean Children and Adolescents (J Obes Metab Syndr 2017; 26: 204–9)
- Characterization of changes in temporal concentrations of fibroblast growth factor 21 (FGF21) before and after parturition in multiparous beef cows
- Metabolic Stress Hormone FGF21: From Physiology to Pharmacology
- Exercise, FGF21, and PGC-1: roles in hepatic metabolism
- The role of FGF21 in the metabolic response to amino acid restriction
- Hepatic FGF21 Expression Is Repressed after Simvastatin Treatment in Mice
- Hypocaloric Diet Prevents the Decrease in FGF21 Elicited by High Phosphorus Intake
- P27. The fasting hormone FGF21-an alternative therapy for Alzheimer’s disease?
- Dietary Carbohydrates but Not Proteins Are the Main Nutritional Determinant of FGF21 Production in Mice
- Synchronizing Metabolism, Physiology, and Behavior Through mTORC1 and FGF21
- Dietary Protein Restriction and FGF21 Influence Bone Morphology
- Translational Control of FGF21 mRNA Expression is Responsive to Nutritional Stress
- Effect of FGF21 on TLR4/p38MAPK Signaling Pathway in Nonalcoholic Fatty Liver Diseases of Rats
- Long-acting FGF21 inhibits retinal vascular leakage in vivo and in vitro model
- Patent: Methods of Treating FGF21-Associated Disorders
- 1957-P: Intermittent Ketogenic Diet Ameliorates Diet-Induced Obesity and Fatty Liver with Improved FGF21 Signaling
- Abstract WMP81: FGF21 Reduces Post-Stroke Blood Brain Barrier Damage in Diabetic db/db Male Mice
- FGF21 resistance in adipose tissues as a cause of insulin resistance?
- The impact of FGF21 on cardiac and whole-body energy metabolism
- Preface to special issue on ‘The hormone FGF21: a paramount actor of endocrine metabolic regulation, and even more’
- Relationship of FGF21 Levels With Major Cardiovascular Events in Patients Treated With Atorvastatin (From the Treating to New Targets [TNT] Study)
- The role of fibroblast growth factor 21 (FGF21) in the regulation and correction of carbohydrate and lipid metabolism
- Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice
- FGF21 inhibits omentin expression in adipocytes
- The Protection of FGF21 on Chronic-Binge Alcohol-Induced Liver Injury
- Low Protein/low Methionine/high Carbohydrate Diets Induce Hyperphagia, Increase Energy Expenditure and FGF21, but Modestly Affect Adiposity in Female BalbC …
- Oral fructose does not acutely affect circulating FGF21 in mice
- Administration of FGF21 analogue ameliorates hyperglycemia in streptozotocin-induced diabetic mice
- 233-LB: Spinal Cord Injury Inhibited-FGF21 Signaling Is Associated with Dysregulation of Metabolic Gene Expression in Mouse Liver and Adipose Tissue
- KLB, Encoding the Co-receptor for FGF21, is Mutated in Congenital Hypogonadotropic Hypogonadism
- Preparation of Prokaryotic Expression Construct of Human FGF21 cDNA and Its Recombinant Protein Expression
- FGF21 Is Epigenetically Regulated by a Methyl Donor Rich Diet and a Transgenerational Model of IUGR.
- Effects of eight-week resistance training on serum level of β Klotho and FGF21 in diabetic women with non-alcoholic fatty liver disease
- Mitogenic response of human carcinoma cells to the liver-derived hormone FGF21
- FGF21 promotes the growth and proliferation of melanoma cells through regulating intracellular fatty acid oxidation
- Induction of FGF21 by CO/PERK/ATF4 Pathway Mediates Metabolic Homeostasis
- Protection of FGF21 as well as metallothionein for high fat diet induced cardiomyocyte impairment.
- Estimation of FGF21 Concentration in Prepubertal Children with Growth Hormone Deficiency before and after 6 Months of Growth Hormone Treatment
- FGF21, irisin and other novel players in endocrine metabolic regulation
- 523: Fibroblast Growth Factor 21 (FGF21) protein levels in the placenta of macrosomic infants
- Cardiac Fibroblast-derived FGF21 is a Novel Therapeutic Target for Cardiac Pathological Remodeling
- Expression of FGF21 and β-Klotho regulate hepatic fibrosis through NF-κB and JNK pathways
- Serum FGF21 Levels in Obese Korean Children and Adolescents (J Obes Metab Syndr 2017; 26: 204-9)
- Protein restriction induces FGF21-dependent mechanisms that are distinct from dietary restriction to protect mice from high-fat diet-induced obesity and glucose …
- 1833-P: A Novel Genetic Modified and Pegylated FGF21 Analog for the Treatment of Nonalcoholic Steatohepatitis in Nonhuman Primates
- Central resitin infusion impairs FGF21/FGFR1/β-Klotho hypothalamic expression and promotes peripheral FGF21 resistance: involvement of resistin/TLR4 signalling …
- Serum levels of FGF21 are reduced and negatively correlated with adiponectin in children with Prader-Willi syndrome
- Autophagy, FGF21 and glucagon during critical illness: interactions and therapeutic perspectives
- The Effects of Obesity, Weight Loss, and Weight Gain on Thymic Expression of FGF21
- FGF21 regulates circadian behavior and metabolism by acting on the nervous system
- The Carbohydrate-and Alcohol Intakes Associated FGF21 Genotype, Change in Alcohol Consumption, and Weight Change
- Association of serum FGF21 levels with clinical parameters in elder patients with type 2 diabetes.
- Towards Examining FGF21 Secretion from Pancreatic Islets in a Microfluidic Device
- High Casein Diet Differentially Alters FGF21 Levels in Plasma and Cardiac Tissue in Rats
- Fructose ingestion acutely stimulates circulating FGF21 levels in humans
- Effects of Hydroalcoholic Extract of Sargassum Oligocystum on Serum Concentration of SIRT1 and FGF21 in Streptozotocin Induced Diabetic Rat
- P107: NLRP3 inflammasome activation in macrophages suppresses FGF21 production in hepatocytes
- Potential role of FGF21 in the metabolic pathophysiology of an ovine model of polycystic ovary syndrome
- Skeletal muscle mitochondrial uncoupling induces a metabolic rescue cycle involving FGF21 as a myokine
- Hepatic regulation of VLDL receptor by PPARb/d and FGF21 modulates non-alcoholic fatty liver disease
- 227-LB: Dietary Protein Restriction Induced–FGF21 Improves Metabolic Health during Aging
- Association between Serum FGF21 levels and bone mineral density in healthy postmenopausal Korean women
- Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates
- Research progress on glycolipid metabolism regulating of FGF19 and FGF21 in adipose tissue
- Cord Blood FGF21 and Leptin as Candidate Biomarkers of Early Infant Linear Growth Velocity in a Low‐Income Country
- Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin 2 resistant mouse models—-Association with liver and adipose tissue effects 3
- THE EFFECT OF ONE SESSION OF ENDURANCE TRAINING ON SERUM LEVELS OF FGF21 AND INSULIN RESISTANCE IN SEDENTARY WOMEN
- Nutritional regulation of the hepatokine FGF21 in the liver: interdependence of the transcription factors ChREBP and PPARα
- Oral recombinant Lactococcus lactis NZ3900 expressing bioactive human FGF21 reduced body weight of DbDb mice through the activity of brown adipose tissue
- SUN-253 FGF21 correlates positively with arteriovenous fistula occlusion in hemodialysis patients
- MUSCLE-RELATED miRNAS AND ITS RELATIONSHIP WITH CIRCULATING GDF15 AND FGF21 LEVELS IN PATIENTS WITH CARDIAC CACHEXIA
- Heme Oxygenase-PPARα Induction of FGF21 in Hepatocytes Recruits pAMPK/pAKT and Attenuates Insulin Resistance in Obese Mice
- … Children and Adolescents Have Higher Bone Mineral Density Than Normal Weighted Controls but Lower than Metabolically Healthy Obeses: No Effect of FGF21 …
- LY2405319, a analog of FGF21 ameliorates α-SMA production through inhibition of succinate-GPR91 pathway in mice
- GW26-e1025 Fenofibrate Prevention of Diabetic Cardiomyopathy Is Mediated by FGF21 Via Sirt1-Dependent Autophagy Modulation
- Pterostilbene inhibits palmitate-induced lipid deposition in L6 myotubes by modulating PLIN5/FGF21 pathway.
- … ARTICLE by a Recently Elected Academy Member: Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21
- PO-163 Aerobic exercise activates myocardial FGF21/FGFR1/PI3K-AKT signaling pathway and inhibits cardiomyocyte apoptosis in post-myocardial infarction rats
- Thyroid Hormone-Induced Expression of the Hepatic Scaffold Proteins Sestrin2, β-Klotho, and FRS2α in Relation to FGF21-AMPK Signaling
- Impacts of prenatal FGF21 upregulation on the thermogenic gene expression in the white adipose tissues of male C57BL/6J mice at adult stages
- Vildagliptin Attenuates Cardiac Hypertrophy and Improves Ventricular Efficiency Through FGF21 Expression in Pressure-overloaded Mouse Heart
- 1811-P: Induction of Hepatic Steatosis by a Methionine Choline Deficient Diet Promotes FGF21-Induced Insulin Secretion Independent of Diabetes
- Effect of a bout of acute cold water immersion on circulating FGF21, Irisin and T3 hormones in SCUBA divers
- Decreased beige adipocyte number and mitochondrial respiration coincide with reduced FGF21 gene expression in Sprague Dawley rats fed prenatal low protein and …
- Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy Wei Wei, Xing-rong An, Shi-Jie Jin, Xiao-Xue Li, Ming Xu
- Role of PPARα in control of torpor through FGF21-NPY pathway: From circadian clock genes to seasonal change and cardiovascular disease
- The Circulating Furan Fatty Acid Metabolite CMPF Directly Enhances Hepatic FGF21 Secretion and Lipid Metabolism
- FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in …
- Withdrawal: Increased expression of fibroblast growth factor 21 (FGF21) during chronic undernutrition causes growth hormone insensitivity in chondrocytes by …
- High Intensity Aerobic Exercise Activates Hepatic Fatty Acid Metabolism Related to PPARalpha-CREBH-FGF21 Axis in Non-alcoholic Fatty Liver Mice Rater than …
- BIO89-100, a GlycoPEGylated FGF21 Analog, Improved Serum Lipids and Extended Half-Life in a Controlled Single Ascending Dose Trial in Healthy Subjects
- Resveratrol stimulation of SIRT1 & exogenous delivery of FGF21 mimics metformin’s ability to alleviate non-alcoholic fatty liver disease caused by diet-induced obesity
- Fibroblast growth factor 21 (FGF21) response in alcohol induced “acute-on-chronic liver injury”(ACLI) model
- 222-LB: Diabetes Induces Liver Inflammation and FGF21 through C-Jun NH2-Terminal Kinase Pathways
- Fibroblast Growth Factor 21 (FGF21) Mouse (E. coli), Tagless
- 1896-P: Adipocyte-Derived Fibroblast Growth Factor 21 (FGF21) Contributes to Circulating FGF21 Pools in Diet-Induced Obese Mice
- Defining the role of Fibroblast growth factor 21 (FGF21) in the pathogenesis of growth hormone resistance and subsequent growth failure in chronic childhood …
- Understanding the Molecular Basis for FGF15/19 and FGF21 Actions on Energy Homeostasis
- Hormonal Responses that Regulate the Metabolic Benefits of Exercise: The Contribution of the Melanocortin System and the Fibroblast Growth Factor 21 (FGF21) …
- … factor 21 (FGF21) coupled with reduced adipose tissue BetaKlotho and FGF21 receptor 1 (FGFR1) expression in Type 2 diabetes may in part explain FGF21 …
- Fibroblast Growth Factor 21 (FGF21) Mouse (E. coli), His-Tagged
- Pharmaceutical inactivation of Erk1/2 does not affect function of FGF21 to regulate glucose and lipid metabolic hemostasis
- R‐α‐lipoic acid potentiates fasting‐induced transcription and secretion of hepatic fibroblast growth factor 21 (FGF21)
- Fibroblast growth factor 21 (FGF21) has a beneficial effect on carbohydrate and lipid metabolism and taste preferences in male and female mice with diet-induced …
- … protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21 …
- Fibroblast growth factor 21 (FGF21) and diabetes-induced vascular disease
- Anti-adiposity impact of phosphodiesterase-5 inhibitor, Sildenafil is possibly through browning of white adipose tissue and FGF21 in obese rats
- Fibroblast Growth Factor 21 (FGF21) Human (E. coli), Tagless
- MON-163 Lowering of Circulating FGF21 by Modulation of Bile Acid Metabolism in Healthy Males
- The mechanistic role of Fibroblast growth factor 21 (FGF21) in Growth Hormone resistance secondary to chronic childhood conditions
- Sulforaphane Downregulates Hepatic Fibroblast Growth Factor 21 (FGF21) of Diet Induced Obese Mice
- The role of the G-protein coupled receptor 120 (GPR120) on the FGF21 system in white and brown adipose tissues
- Undernutrition and Growth Failure: Is Fibroblast Growth Factor 21 (FGF21) The Missing Link
- Aerobic and Resistance Exercises Modulate Fibroblast Growth Factor-21 (FGF21) Level in Menopause Women with Type II Diabetic
- Fibroblast Growth Factor 21 (FGF21) Human (E. coli), His-Tagged
- Differentiated embryo chondrocyte1 (DEC1) is a novel negative regulator of hepatic Fibroblast growth factor 21 (FGF21) in aging mice
- Combination of metformin plus orlistat prevents tumor progression: novel role of the metabolic hormone fibroblast growth factor 21 (FGF21)
- Reply to Correspondence HEP-15-1008 “AHR-FGF21 dissociation of fatty liver from insulin resistance: a timely matter?”
- The role of metabolic hormone fibroblast growth factor 21 (FGF21) in mammalian hibernation using transgenic ground squirrels
- Research Article Circulating CTRP1 Levels in Type 2 Diabetes and Their Association with FGF21
- 301-LB: Effects of Amino Acid Restriction on Development of Type 2 Diabetes in NZO Mice by FGF21 Secretion
- 300-LB: FGF21 and a ß3-Adrenergic Agonist Synergistically Lower Blood Glucose in Obese Mice at Thermoneutrality
- FGF21 exerts comparable pharmacological efficacy with Adalimumab in ameliorating collagen-induced rheumatoid arthritis by regulating systematic inflammatory response
- Increased plasma FGF21 level as an early biomarker for insulin resistance and metabolic disturbance in obese insulin-resistant rats
- Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing
- THE EFFECT OF EIGHT WEEKS HIGH INTENSITY INTERVAL RAINING (HIIT) ON SERUM AMOUNTS OF FGF21 AND IRISIN IN SEDENTARY OBESE WOMEN
- Mapping the response of human fibroblast growth factor 21 (FGF21) promoter to serum availability and lipoic acid in HepG2 hepatoma cells
- HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection
- Parsing the Potential Neuroendocrine Actions of FGF21 in Primates
- [Study on the kidney impairment and expressions of FGF21 from a rat model of vascular calcification].
- Berberine-induced activation of AMPK increases hepatic FGF21 expression via NUR77
- Negative correlation between cerebrospinal fluid FGF21 levels and BDI scores in male Chinese subjects
- FGF21 acts as a negative regulator of bile acid synthesis
- Fgf21 regulates T-cell development in the neonatal and juvenile thymus
- HRD1‐ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination
- Interaction of glucocorticoids with FXR/FGF19/FGF21-mediated ileum-liver crosstalk
- FGF21 increases water intake, urine output and blood pressure in rats
- Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues
- FGF21 attenuates hypoxia‑induced dysfunction and apoptosis in HPAECs through alleviating endoplasmic reticulum stress
- A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21
- Contribution of serum FGF21 level to the identification of left ventricular systolic dysfunction and cardiac death
- Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans
- An Exome-Chip Association Analysis in Chinese Subjects Reveals a Functional Missense Variant of GCKR That Regulates FGF21 Levels
- Mediterranean Tomato‐Based Sofrito Sauce Improves Fibroblast Growth Factor 21 (FGF21) Signaling in White Adipose Tissue of Obese ZUCKER Rats
- Thyroid Hormone-Induced Expression of the Hepatic Scaffold Proteins Sestrin2, β-Klotho, and FRS2α in Relation to FGF21–AMPK Signaling
- Baseline Circulating FGF21 Concentrations and Increase after Fenofibrate Treatment Predict More Rapid Glycemic Progression in Type 2 Diabetes: Results from the FIELD Study
- FGF21 inhibits adiponectin secretion in human adipocytes
- Chimeric fgf21 proteins with enhanced binding affinity for beta-klotho for the treatment of type ii diabetes, obesity, and related metabolic disorders
- Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis
- IGFBP1—hepatokine and target for FGF21-mediated bone loss
- Methods of treating fgf21-associated disorders
- Serum FGF21 Levels in Obese Korean Children and Adolescents
- FGF21 Is Associated with Acanthosis Nigricans in Obese Patients
- FGF21 Alleviates Hepatic Endoplasmic Reticulum Stress under Physiological Conditions
- The Role of FGF21 in Pancreatic Islet Metabolism
- FGF21 regulates insulin sensitivity following long-term chronic stress
- The swinging pendulum of biomarkers in mitochondrial disease
The role of FGF21 - LPS infusion suppresses serum FGF21 levels in healthy adult volunteers
- Circulating FGF21 Levels in Human Health and Metabolic Disease
- FGF21 regulates melanogenesis in alpaca melanocytes via ERK1/2-mediated MITF downregulation
- Letter to the Editor: Potential Role for FGF21 as a Mediator of Thyroid Hormone Effects on Metabolic Regulation
- Reduced adiposity attenuates FGF21 mediated metabolic improvements in the Siberian hamster
- Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure
- Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
- The role of FGF21 in type 1 diabetes and its complications
- Abstract 1577: Levels of Fibroblast Growth Factor 21 (FGF21) in serum as diagnostic biomarker in patients with breast cancer
- Practical prospects for boosting hepatic production of the “pro-longevity” hormone FGF21
- FGF21 protects myocardial ischemia-reperfusion injury through reduction of miR-145-mediated autophagy
- FGF21 is induced in cisplatin nephrotoxicity to protect against kidney tubular cell injury
- FGF21 trafficking in intact human cellsrevealed by cryo-electron tomographywith gold nanoparticles
- Oral bezafibrate induces daily torpor and FGF21 in mice in a PPAR alpha dependent manner
- Serum FGF21 in girls with anorexia nervosa – comparison to normal weight and obese female adolescents
- Effects of central FGF21 infusion on the hypothalamus–pituitary–thyroid axis and energy metabolism in rats
- Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation
- Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH
- Sterol 12α-hydroxylase Aggravates Dyslipidemia by Activating the Ceramide/mTORC1/SREBP1C Pathway via FGF21 and FGF15
- Enhanced expression and distinctive characterization of a long-acting FGF21 and its potential to alleviate nonalcoholic steatohepatitis
- FGF21 protects human umbilical vein endothelial cells against high glucose-induced apoptosis via PI3K/Akt/Fox3a signaling pathway
- Factors associated with cognitive impairment in elderly versus nonelderly patients with metabolic syndrome: the different roles of FGF21
- FGF21 Is Associated with Metabolic Effects and Treatment Response in Depressed Bipolar II Disorder Patients Treated with Valproate
- Highly selective and sensitive measurement of active forms of FGF21 using novel immunocapture enrichment with LC–MS/MS
- FGF21 action on human adipose tissue compromised by reduced βKlotho and FGFR1 expression in type 2 diabetes mellitus
- Ileal Transposition Surgery Decreases Fat Mass and Improves Glucose Metabolism in Diabetic GK Rats: Possible Involvement of FGF21
- THE EFFECT OF 8 WEEKS OF AEROBIC EXERCISE ON SERUM LEVELS OF FGF21, APOLIPOPROTEIN A-1 AND LDL-C TO HDL-C RATIO IN OBESE WOMEN
- Effects of ethinylestradiol-cyproterone acetate vs. pioglitazone-flutamide-metformin on plasma FGF21 levels in adolescent girls with androgen excess.
- TGF-β2, EGF, and FGF21 Growth Factors Present in Breast Milk Promote Mesenteric Lymph Node Lymphocytes Maturation in Suckling Rats
- High plasma FGF21 levels predicts major cardiovascular events in patients treated with atorvastatin (from the Treating to New Targets [TNT] Study)
- Effects of EPA and lipoic acid supplementation on circulating FGF21 and the fatty acid profile in overweight/obese women following a hypocaloric diet
- Letter to the Editor: Comment on “FGF21 Response to Critical Illness: Effect of Blood Glucose Control and Relation With Cellular Stress and Survival” by Thiessen S.E., et al
- FGF21 levels in patients with breast cancer
- FGF21 determined angiogenic phenotypes in pulmonary endothelial cells
- Construction of FGF21 knockout mouse models by the CRISPR/Cas9 system.
- Therapeutic potential of FGF21 in cardiorenal syndrome
- Enhancement of FGF21 expression by site-directed mutagenesis
- Therapeutic potential of FGF21 in diabetes
- Comment on serum FGF21 and RBP4 levels in patients with chronic hepatitis C
- Clinical Study of the Relationship between Serum FGF21 and Metabolic Syndrome
- INCREASED SERUM LEVEL OF FGF21 IN GESTATIONAL DIABETES MELLITUS
- Cloning and expression of human FGF21 gene and purification of recombinant protein
- A Tryptophan Hydroxylase Inhibitor Decreases Hepatic FGF21 Expression and Circulating FGF21 in Mice Fed A High-Fat Diet
- P612 Involvement of the cardiomyokine FGF21 in protection against oxidative stress damage in the heart.
- Abstract 891: FGF21 prevents high fat diet-induced pancreatic cancer in mice expressing oncogenic Kras
- FGF21-FC fusion proteins for treating metabolic disorders
- Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript to FGF21
- In Pursuit of a Biomarker of Weight Gain Susceptibility—Is FGF21 a Candidate?
- Methods of treating metabolic disorders with an FGF21 variant
- Methods of treating, diagnosing or detecting fgf21-associated disorders
- FGF21 is produced by active skeletal muscle during intense exercise in humans: influence of PIO2
- FGF21 decreases food intake and body weight in obese Göttingen minipigs
- Mutual promotion of FGF21 and PPARγ attenuates hypoxia-induced pulmonary hypertension
- Effect of Vigorous Aerobic Exercise on Serum Levels of SIRT1, FGF21 and Fetuin A in Women with Type II Diabetes
- FGF21 underlies a hormetic response to metabolic stress in methylmalonic acidemia
- Lipodystrophy HIV-related and FGF21: A new marker to follow the progression of lipodystrophy?
- Characterization of changes in temporal concentrations of fibroblast growth factor 21 (FGF21) before and after parturition in multiparous beef cows
- TCF4/β‑catenin complex is directly upstream of FGF21 in mouse stomach cancer cells
- Role of adipokines FGF21, leptin and adiponectin in self-concept of youths with obesity
- DEPP/DEPP1/C10ORF10 regulates hepatic glucose and fat metabolism partly via ROS-induced FGF21
- Therapeutic Role of Fibroblast Growth Factor 21 (FGF21) in the Amelioration of Chronic Diseases
- Associations between FGF21, osteonectin and bone turnover markers in type 2 diabetic patients with albuminuria
- [Biological effects of FGF21].
- FGF21 mediates the protective effect of fenofibrate against acetaminophen -induced hepatotoxicity via activating autophagy in mice
- Effect of circulating glucagon and free fatty acids on hepatic FGF21 production in dairy cows
- Increase in FGF21 Stimulates Browning Markers in White Adipose Tissue in Rats Fed a Low Protein High Carbohydrate Diet During Acute Cold Exposure
- Defective autophagy causes a maladaptive cardiac phenotype to exercise that leads to premature death and FGF21-mediated protection against obesity and insulin resistance
- High serum levels of FGF21 are decreased in bipolar mania patients during psychotropic medication treatment and are associated with increased metabolism disturbance
- A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure
- Changes in Plasma Concentrations and mRNA Expression of Hepatokines Fetuin A, Fetuin B and FGF21 in PhysiologicalPregnancy and Gestational Diabetes Mellitus
- Positive correlations between and prediction of FGF21, adiponectin, leptin and NPY concentrations in the cerebrospinal fluid of Chinese subjects using back propagating artificial neural networks
- FGF21 promotes functional recovery after hypoxic-ischemic brain injury in neonatal rats by activating the PI3K/Akt signaling pathway via FGFR1/β-klotho
- Low-protein and methionine, high-starch diets increase energy intake and expenditure, increase FGF21, decrease IGF-1, and have little effect on adiposity in mice
- STUDIES ON THE REGULATION OF FGF21 GENE EXPRESSION BY (R)-α-LIPOIC ACID: MECHANISTIC INSIGHT INTO THE LIPID LOWERING PROPERTIES OF A DITHIOL DIETARY MOLECULE
- High-efficiency expression and secretion of human FGF21 in Bacillus subtilis by intercalation of a mini-cistron cassette and combinatorial optimization of cell regulatory components
- Abstract 16139: Fgf21 Expresses in Diabetic Hearts and Protects from Palmitate- and Diabetes-Induced Cardiac Cell Death In Vitro and In Vivo Via Erk1/2-Dependent P38 Mapk/ampk Signaling Pathways
- Genetic and functional analysis of FGF21 in NAFLD/NASH
- YH25724, a novel long-acting GLP-1/FGF21 dual agonist lowers both non-alcoholic fatty liver disease activity score and fibrosis stage in a diet-induced obese mouse model of biopsy-confirmed non-alcoholic steatohepatitis
- 1104 – Intestinal Serine Protease Inhibition Increases Liver FGF21 Secretion in Diabetic Obese Mice
- FOR THE QUANTITATIVEDETERMINATION OFMOUSE OR RAT FGF21 CONCENTRATIONS IN SERUM AND EDTA PLASMA
- FGF21 ACEs hypertension
- FGF21
- FGF21 gets the juices flowing
- FGF21: How sweet it is!
- Adipose and nonadipose effects of FGF21 delineated
- FGF21 Response to Critical Illness: Effect of Blood Glucose Control and Relation With Cellular Stress and Survival
- mAb about FGF21
- The secret life of FGF21
- FGF21: A biomarker of neuromuscular diseases
- Link between FGF21 and blood pressure
- FGF21: starvation hormone to a clinical drug?
- Adipose and nonadipose effects of FGF21 delineated
- Fgf21 variants
- FGF21—central pathways of action unravelled
- Pharmacological actions of FGF19 and FGF21 revealed
- FGF21 in acute and chronic alcohol consumption
- IGFBP1—hepatokine and target for FGF21-mediated bone loss
- FGF21 — the cause of having a ‘sweet tooth’?
- FGF21 improves glucose homeostasis in diabetes-prone NZO mice
- FGF21 influences a ‘sweet tooth’ in mice
- Exercise, FGF21, and PGC-1 : roles in hepatic metabolism
- Central resitin infusion impairs FGF21/FGFR1/β-Klotho hypothalamic expression and promotes peripheral FGF21 resistance: involvement of resistin/TLR4 signalling pathway
- [Expression of recombinant h-FGF21 in periplasmic space of Escherichia coli].
- The physiology and pharmacology of the fasting-induced hormone, FGF21
- FGF21 : un lien entre reproduction et métabolisme
- FGF21 action in the fat
- Pharmacological actions of FGF19 and FGF21 revealed
- Synchronizing Metabolism, Physiology, and Behavior Through mTORC1 and FGF21
- Dietary Protein Restriction and FGF21 Influence Bone Morphology
- Dynamic FGF21 Expression under Exercise,Fasting and Food Components
- Fibroblast growth factor 21 (FGF21) and diabetes-induced vascular disease
- Are you thirsty? FGF21 might be involved in that too
- Construction and identification of FGF21 adenovirus expression vector
- Oral fructose does not acutely affect circulating FGF21 in mice
- [The Role of FGF21 in Regulating Lipid and Glucose Metabolism].
- FGF21, irisin and other novel players in endocrine metabolic regulation
- FGF21 and Pancreatic Islet Fatty Acid Metabolism
- Serum Levels of FGF21 and Prediction of Cardiovascular Events
- Translational Control of FGF21 mRNA Expression is Responsive to Nutritional Stress
- P27. The fasting hormone FGF21-an alternative therapy for Alzheimer’s disease?
- Fructose ingestion acutely stimulates circulating FGF21 levels in humans
- Association of FGF21 soluble levels with metabolic profile in Gestational Diabetes patients
- FGF21 Levels in Pheochromocytoma/Functional Paraganglioma
- Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue
- FGF21 Levels in Pheochromocytoma/Functional Paraganglioma.
- Key role for FGF21 in GLP1-mediated weight loss
- Cardiac Myocyte KLF5 Regulates Adiposity via Alteration of Cardiac FGF21
- P 223 – Induction of FGF21 by CO/PERK/ATF4 Pathway Mediates Metabolic Homeostasis
- N-terminal modified FGF21 compounds
- FGF19 subfamily members: FGF19 and FGF21
- Fgf21 mutants and uses thereof
- Administration of FGF21 analogue ameliorates hyperglycemia in streptozotocin-induced diabetic mice
- FGF21 Prospects for Applications in Clinical Practice
- Elevated FGF21 during insufficient sleep in active but not sedentary volunteers
- FGF21 derivatives and uses thereof
- Serum FGF21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia
- Role of FGF21 and GCN2 in mediating the metabolic response to dietary protein restriction
- Novel Effects of FGF21 and Exercise on Brown Adipose Tissue Inflammation
- Fgf21 c-terminal peptide optimization
- Methionine restriction prevents onset of type 2 diabetes in NZO mice by FGF21 secretion
- Mitogenic response of human carcinoma cells to the liver-derived hormone FGF21
- Redox Regulation of FGF21 in an Obese “Stress-less” Mouse Model
- Therapeutic Potential of FGF21 in Alzheimer’s Disease
- Therapeutic Approaches to Alzheimer’s Type of Dementia: A Focus on FGF21 Mediated Neuroprotection
- Going hedonic – the role of FGF21 in the preference for sweet and alcohol
- Fibroblast Growth Factor 21 (FGF21) Regulating Sweet & Alcohol Preference
- Autophagy, FGF21 and glucagon during critical illness: interactions and therapeutic perspectives
- FGF21 Receptor Agonists And Uses Thereof
- Fgf21 mimetic antibodies and uses thereof
- Regulation of glucose homeostasis by FGF21
- FGF21 Resistance in Adipose Tissues as a Cause of Insulin Resistance
- Effect of FGF21 on TLR4/p38MAPK Signaling Pathway in Nonalcoholic Fatty Liver Diseases of Rats
- The roles of FGF21 in atherosclerosis pathogenesis
- KLB, Encoding the Co-receptor for FGF21, is Mutated in Congenital Hypogonadotropic Hypogonadism
- Skeletal muscle mitochondrial uncoupling induces a metabolic rescue cycle involving FGF21 as a myokine
- High Intermittent Intensity Training Induces FGF21 Secretion in Obese Rats
- Abstract 4373: Lack of FGF21 promotes NASH-HCC transition via exosome-mediated carcinogenetic signaling
- R-α-lipoic acid potentiates fasting-induced transcription and secretion of hepatic fibroblast growth factor 21 (FGF21)
- FGF21 causes GH resistance in human chondrocytes through activation of SOCS2 and inhibition of IGF1 expression
- Fibroblast Growth Factor 21 (FGF21) Human (E. coli), Tagless
- Serum FGF21 Levels in Obese Korean Children and Adolescents
- THE EFFECT OF AEROBIC TRAINING ON LEVELS OF FGF21 IN DIABETIC WOMAN
- Membraneless reproducible MoS2 field-effect transistor biosensor for high sensitive and selective detection of FGF21
- High Casein Diet Differentially Alters FGF21 Levels in Plasma and Cardiac Tissue in Rats
- FGF21 conjugates and anti-diabetic uses thereof
- FGF21 Mouse (E. coli)
- FGF21 reloaded: challenges of a rapidly growing field
- Expression and Significance of FGF21 in the Serum of Patients with Polycystic Ovarian Syndrome
- FGF21 regulates circadian behavior and metabolism by acting on the nervous system
- Regulation of FGF21 Gene Expression by Nutritional Signals and Physical Activity in vivo and in vitro
- FGF21 signalling pathway and metabolic traits – genetic association analysis
- Research progress on glycolipid metabolism regulating of FGF19 and FGF21 in adipose tissue
- Sex dimorphism in the Fgf21 gene expression in liver and adipose tissues is dependent on the metabolic condition
- Dietary Methionine Restriction Reduces Inflammation Independent of FGF21 Action
- IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF FGF21 MUTATIONS IN OBESE INDIVIDUALS.
- Corrigendum to “ATF4-and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress”
- Process development of a FGF21 protein–antibody conjugate
- Altered Fgf21 response in alcohol induced “Acute-on-chronic liver injury” (ACLI) model
- A3155 A2A Receptor Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21
- Dietary protein and age-dependent female fertility: FGF21 trumps mTORC1
- “ROLE OF FIBROBLAST GROWTH FACTOR (FGF21) IN DIABETES”
- FGF21-Fc FUSION PROTEINS FOR TREATING METABOLIC DISORDERS
- Dietary Carbohydrates but Not Proteins Are the Main Nutritional Determinant of FGF21 Production in Mice
- FGF21 as Modulator of Metabolism in Health and Disease
- The mechanistic role of Fibroblast growth factor 21 (FGF21) in Growth Hormone resistance secondary to chronic childhood conditions
- Serum levels of FGF21 are reduced and negatively correlated with adiponectin in children with Prader-Willi syndrome
- The role of FGF21 in regulating energy homeostasis
- Expression, Purification and Characterization of Recombinant Canine FGF21 in Escherichia coli
- Going Back to the Biology of FGF21: New Insights
- Serum FGF21 Levels in Obese Korean Children and Adolescents (J Obes Metab Syndr 2017;26:204–9)
- Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript to FGF21
- Process for preparing FGF21 with low degree of O-glycosylation
- FGF21 activation-mediated islet autophagy in Type 2 diabetes with pharmacotherapeutic potential
- Raised circulating fibroblast growth factor 21 (FGF21) coupled with reduced adipose tissue BetaKlotho and FGF21 receptor 1 (FGFR1) expression in Type 2 diabetes may in part explain FGF21 resistance
- MON-163 Lowering of Circulating FGF21 by Modulation of Bile Acid Metabolism in Healthy Males
- Activation of AK005401 aggravates acute ischemia/reperfusion mediated hippocampal injury by directly targeting YY1/FGF21.
- Adipose tissue FGF21 resistance contributes to hypoadiponectinemia and insulin resistance in obesity: Role of miR-34a
- Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21
- Long-acting fgf21 fusion proteins and pharmaceutical composition comprising same
- Hepatic Endoplasmic Reticulum Associated Degradation (ERAD) manages FGF21 levels and metabolism via CREBH during fasting-feeding and growth
- FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics
- 282-LB: Dysregulated FGF21 Links Hepatic Insulin Resistance to Dysfunctional BAT
- FGF21 deficiency exacerbates chronic alcohol induced fatty liver disease via a p38MAPK and PGC-1α mediated pathway (653.13)
- Abstract 17746: Cardiomyocyte-Specific KLF5 Deletion Accelerates Diet-Induced Obesity via Cardiac FGF21
- Abstract 13213: Protective Role of Fgf21 in Adverse Cardiac Remodeling After Myocardial Infarction
- FGF21 Is Epigenetically Regulated by a Methyl Donor Rich Diet and a Transgenerational Model of IUGR.
- Increased Fructose Consumption has Sex‐Specific Effects on FGF21 Levels in Humans
- Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21
- Methionine Restriction Alleviates Aging-related Cognitive Dysfunction via Stimulating FGF21-driven Mitochondrial Biogenesis (P14-026-19)
- Method of Treating or Ameliorating Type 1 Diabetes Using FGF21
- Fgf21 compound / glp-1r agonist combinations with optimized activity ratio
- SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms
- PO-163 Aerobic exercise activates myocardial FGF21/FGFR1/PI3K-AKT signaling pathway and inhibits cardiomyocyte apoptosis in post-myocardial infarction rats
- Reply to Correspondence HEP-15-1008 “AHR-FGF21 dissociation of fatty liver from insulin resistance: a timely matter?”
- YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity
- FGF21 Coordinates Adiponectin to Mediate the Beneficial Effects of Low-Protein Diet on Primordial Follicle Reserve
- Abstract 5747: Lack of FGF21 accelerates the Th17-IL-17 axis-mediated transition from nonalcoholic steatohepatitis to hepatocellular carcinoma
- THE EFFECTS OF HIGH INTENSITY INTERVAL TRAINING ON SERUM LEVELS OF FGF21 AND INSULIN RESISTANCE IN OBESE MEN
- Effects of Hydroalcoholic Extract of Sargassum Oligocystum on Serum Concentration of SIRT1 and FGF21 in Streptozotocin Induced Diabetic Rat
- Skeletal muscle-specific eIF2α phosphorylation controls amino acid metabolism and FGF21– mediated non-cell-autonomous energy metabolism
- Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates
- Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 co-repressor complex in mice Abbreviated Title: LXRb regulation of FGF21
- Hypocaloric Diet Prevents the Decrease in FGF21 Elicited by High Phosphorus Intake
- Delayed recanalization at 3 days after permanent MCAO attenuates neuronal apoptosis through FGF21/FGFR1/PI3K/Caspase-3 pathway in rats
- Exercise ameliorates the FGF21–adiponectin axis impairment in diet-induced obese mice
- [SREBP-1c knockdown attenuated fatty degeneration in hepatic L02 cells and inhibited CCL2 and FGF21 protein expression].
- Lipid Response to Amino Acid Starvation inFat Cells: Role of FGF21
- [Effect of EPO on PRDM16, FGF21 expression and STAT phosphorylation of brown adipose tissue in HFD mice].
- The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man
- Association between Serum FGF21 levels and bone mineral density in healthy postmenopausal Korean women
- Towards Examining FGF21 Secretion from Pancreatic Islets in a Microfluidic Device
- TRIB3 limits FGF21 induction during in vitro and in vivo nutrient deficiencies by inhibiting C/EBP–ATF response elements in the Fgf21 promoter
- [THE ROLE OF FIBROBLAST GROWTH FACTOR 21 (FGF21) IN THE REGULATION AND CORRECTION OF CARBOHYDRATE AND LIPID METABOLISM].
- Glp-1 and fgf21 combinations for treatment of diabetes type 2
- Hypocaloric Diet Prevents the Decrease in FGF21 Elicited by High Phosphorus Intake
- Preface to special issue on ‘The hormone FGF21: a paramount actor of endocrine metabolic regulation, and even more’
- Cord Blood FGF21 and Leptin as Candidate Biomarkers of Early Infant Linear Growth Velocity in a Low- Income Country
- Clinical significance and detection of levels of serum FGF21 in patients with type II diabetes complicated fatty liver
- Measurement Of FGF21 As A Biomarker Of Fructose Metabolism And Metabolic Disease
- Hepatic Oleate Deficiency Represses De Novo Lipogenesis and Enhances Systemic Glucose Utilization Through FGF21 During High Carbohydrate Feeding
- Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice
- Changes in selected biochemical parameters (including FGF21) during subclinical and clinical ketosis in dairy cows
- FGF21 Protects Against Hypoxia Injury Through Inducing HSP72 in Cerebral Microvascular Endothelial Cells
- Alteration in serum concentrations of FGF19, FGF21, and FGF23 in patients with urothelial carcinoma
- Oncogenic KRAS Reduces Expression of FGF21 in Acinar Cells to Promote Pancreatic Tumorigenesis in Mice on a High-Fat Diet
- The role of FGF21 in the metabolic response to amino acid restriction
- Predictive value of combined serum FGF21 and free T3 for survival in septic patients
- Hepatic posttranscriptional network comprised of CCR4–NOT deadenylase and FGF21 maintains systemic metabolic homeostasis
- Engineered FGF21 variant, LY2405319, can protect nonalcoholic fatty liver disease through enhancing hepatic mitochondrial function
- A high circulating FGF21 level as a prognostic marker in patients with acute myocardial infarction
- Association of serum FGF21 levels with clinical parameters in elder patients with type 2 diabetes.
- Abstract 1439: Combination of metformin plus orlistat prevents tumor progression: novel role of the metabolic hormone fibroblast growth factor 21 (FGF21)
- FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism
- Understanding the Molecular Basis for FGF15/19 and FGF21 Actions on Energy Homeostasis
- GW26-e1025 Fenofibrate Prevention of Diabetic Cardiomyopathy Is Mediated by FGF21 Via Sirt1-Dependent Autophagy Modulation
- The role of the G-protein coupled receptor 120 (GPR120) on the FGF21 system in white and brown adipose tissues
- Relationship between Circulating FGF21 Concentrations and the Severity of Coronary Artery Damage in Subjects with Cardiovascular Disease
- Abstract 16199: The Carbohydrate- and Alcohol Intakes Associated FGF21 Genotype, Change in Alcohol Consumption, and Weight Change
- A Tryptophan Hydroxylase Inhibitor Increases Hepatic FGF21 Production and Decreases Hepatic Gluconeogenesis Independently of Insulin in db/db Mice
- OR01-3 MicroRNA-34a-Mediated FGF21 Resistance in the Adipose Tissue Contributes to Insulin Resistance and Hypoadiponectinemia in Diet-Induced Obesity
- 300-LB: FGF21 and a ß3-Adrenergic Agonist Synergistically Lower Blood Glucose in Obese Mice at Thermoneutrality
- Genetic Variants Flanking the FGF21 Gene Were Associated with Renal Function in Chinese Patients with Type 2 Diabetes
- Characterization and Quantification of an Fc-FGF21 Fusion Protein in Rat Serum Using Immunoaffinity LC-MS
- THE EFFECT OF ONE SESSION OF ENDURANCE TRAINING ON SERUM LEVELS OF FGF21 AND INSULIN RESISTANCE IN SEDENTARY WOMEN
- Protein intake and amino acid supplementation regulates exercise recovery and performance through the modulation of mTOR, AMPK, FGF21 and immunity
- Fibroblast Growth Factor 21 (FGF21), Free Fatty Acid (FFA), High Sensitivity C-reactive Protein (hsCRP) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) Among Indonesian Obese Non-Diabetic Males
- The Liver-Derived Endocrine Hormone FGF21 Alters Metabolism and Diurnal Behavior via the Nervous System
- Abstract 12454: Vildagliptin Attenuates Cardiac Hypertrophy and Improves Ventricular Efficiency Through FGF21 Expression in Pressure-overloaded Mouse Heart
- Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals
- 301-LB: Effects of Amino Acid Restriction on Development of Type 2 Diabetes in NZO Mice by FGF21 Secretion
- The Circulating Furan Fatty Acid Metabolite CMPF Directly Enhances Hepatic FGF21 Secretion and Lipid Metabolism
- Differentiated embryo chondrocyte 1 (DEC1) is a novel negative regulator of hepatic fibroblast growth factor 21 (FGF21) in aging mice
- FGF21 maybe have a Protective Role against Obesity in Cases of High-fat Diets, in Adult Mice, Malnourished during Their Embryonic Life
- Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice
- Comparison of FGF21 level in type 2 diabetic patients with healthy subjects and correlation of its with metabolic syndrome components
- Genetic disruption of uncoupling protein 1(UCP1) in mice renders brown adipose tissue a significant source of FGF21 secretion
- Abstract 16335: Circulating FGF21 Predicts the Incidence of Contrast-Induced Nephropathy and Renal Function Decline in Patients With Stable Angina
- Identification of a crucial amino acid responsible for the loss of specifying FGFR1–KLB affinity of the iodinated FGF21
- Abstract 74: Heme Oxygenase-PPARα Induction of FGF21 in Hepatocytes Recruits pAMPK/pAKT and Attenuates Insulin Resistance in Obese Mice
- Fasting Insulin and Alanine Amino Transferase, but not FGF21, Were Independent Parameters Related with Irisin Increment after Intensive Aerobic Exercising
- Nutritional regulation of the hepatokine FGF21 in the liver : interdependence of the transcription factors ChREBP and PPARα
- Role of PPARα in control of torpor through FGF21-NPY pathway: From circadian clock genes to seasonal change and cardiovascular disease
- The role of metabolic hormone Fibroblast Growth Factor 21 (FGF21) in mammalian hibernation using transgenic ground squirrels
- Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21
- Gene Expression Profiling Reveals That PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice
- Low Protein/low Methionine/high Carbohydrate Diets Induce Hyperphagia, Increase Energy Expenditure and FGF21, but Modestly Affect Adiposity in Female BalbC Mice (OR09-01-19)
- Decreased beige adipocyte number and mitochondrial respiration coincide with reduced FGF21 gene expression in Sprague Dawley rats fed prenatal low protein and postnatal high fat diets
- Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 co-repressor complex in mice Abbreviated Title: LXRb regulation of FGF21
- FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in
- Responses that Regulate the Metabolic Benefits of Exercise: The Contribution of the Melanocortin System and the Fibroblast Growth Factor 21 (FGF21
- Erratum. Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the MetabolicSyndrome in Humans. Diabetes 2008;57:1246–1253
- Mice lacking neutral amino acid transporter B⁰AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control
- Association of the 3′UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity
- Abstract 11292: Relationship of FGF21 Levels With Major Cardiovascular Events in Patients Treated With Atorvastatin (From the Treating to New Targets [TNT] Study)
- Successful Glycemic Control Decreases the Elevated Serum FGF21 Level without Affecting Normal Serum GDF15 Levels in a Patient with Mitochondrial Diabetes
- O29: Régulation circadienne et nutritionnelle de FGF21 par PPARalpha
- FGF21‘in Obezite ve Kardiyovasküler Risk Faktörleri ile İlişkisi
- Verikokeella testattava FGF21 on mitokondriotautien uusi merkkiaine
- O03 Le FGF21 améliore le profil métabolique des souris lipodystrophiques Bscl2-/-
- Tratamiento de la diabetes y la obesidad mediante una terapia génica con FGF21.
- Transplantation of Mesenchymal Stem Cells Overexpressing FGF21 Facilitates Cognitive Recovery and Enhances Neurogenesis in a Mouse Model of Traumatic Brain Injury
- Mice lacking neutral amino acid transporterB0AT1 (Slc6a19) have elevated levels of FGF21and GLP-1 and improved glycaemic control
- Resveratrol stimulation of SIRT1 & exogenous delivery of FGF21 mimics metformin’s ability to alleviate non-alcoholic fatty liver disease caused by diet-induced obesity
- Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21
- Changes in Liver Gene Expression and Plasma Concentration of Rbp4, Fetuin-A, and Fgf21 in Sprague-Dawley Rats Subjected to Different Dietary Interventions and Bariatric Surgery
- Ishige okamurae Extract Ameliorates the Hyperglycemia and Body Weight Gain of db/db Mice through Regulation of the PI3K/Akt Pathway and Thermogenic Factors by FGF21
- Moxibustion-Simulating Bipolar Radiofrequency Suppresses Weight Gain and Induces Adipose Tissue Browning via Activation of UCP1 and FGF21 in a Mouse Model of Diet-Induced Obesity
- Defining the role of Fibroblast growth factor 21 (FGF21) in the pathogenesis of growth hormone resistance and subsequent growth failure in chronic childhood conditions
- PO029 ASSOCIATIONS OF CHEMERIN AND FGF21 WITH SUBCLINICAL ATHEROSCLEROSIS AND ADVERSE LIPID METABOLISM IN TYPE 2 DIABETES
- Chronic exercise alleviates obesity-related metabolic dysfunction by enhancing FGF21 sensitivity in adipose tissues
- Correlations between serum FGF21 and IRISIN levels and nutritional, biochemical, and anthropometric parameters in non-alcoholic fatty liver disease
- Elevated fibroblast growth factor 21 (FGF21) levels in obese, insulin resistant states are normalised by fenretinide treatment via retinoic acid signalling
- Investigating the role of fibroblast growth factor-21 (FGF21) in regulating microglial inflammatory response
- Chronic activation of PPAR alpha with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21
- Irisin but not FGF21 correlates with insulin sensitivity in athletes and sedentary subjects
- FGF21 Is an Insulin-Dependent Postprandial Hormone in Adult Humans
- FGF21 ameliorates gluttony-induced obesity and obesity-related inflammatory parameters
- Decreased serum FGF21 concentration is associated with central obesity: 56
- Aerobic training increased FGF21 expression and attenuated cognition in Alzheimer’s disease mice
- Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action
- High fat feeding for 5 days of young healthy men leads to a 3 fold increase in plasma FGF21
- PE-392 FGF21 is an Akt1-Regulated Skeletal Muscle-Secreted Factor(PE066,Diabetes 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- Paradoxical resistance to diet-induced obesity in UCP1 KO mice is mediated by FGF21
- Cardioprotective role of myocardial ischemia-induced hepatic FGF21
- Expression of placental fibroblast growth factor 21 (FGF21) is increased in placental tissue from pregnancies with preeclampsia
- Placental Fibroblast Growth Factor 21 (FGF21) mRNA but Not Protein Expression Is Increased in Preeclampsia
- [Secreted factor, FGF21, regulates diverse biological processes].
- GW29-e1353 A2A Receptor Activation Attenuates Hypertensive Cardiac Remodeling via Promoting Brown Adipose Tissue-Derived FGF21
- Corrigendum to “ATF4-and CHOP-Dependent Induction of FGF21 through Endoplasmic Reticulum Stress”
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