ANTI-AGING EFFECTS OF FLAVONOIDS & POLYPHENOLS
January 22, 2020P38MAPK
January 23, 2020Abstract
Aging is the progressive accumulation of damage to an organism over time leading to disease and death. Aging research has been very intensive in the last years aiming at characterizing the pathophysiology of aging and finding possibilities to fight age-related diseases. Various theories of aging have been proposed. In the last years advanced glycation end products (AGEs) have received particular attention in this context. AGEs are formed in high amounts in diabetes but also in the physiological organism during aging. They have been etiologically implicated in numerous diabetes- and age-related diseases. Strategies inhibiting AGE accumulation and signaling seem to possess a therapeutic potential in these pathologies. However, still little is known on the precise role of AGEs during skin aging. In this review the existing literature on AGEs and skin aging will be reviewed. In addition, existing and potential anti-AGE strategies that may be beneficial on skin aging will be discussed.
Keywords: : advanced glycation end products, skin aging, photoaging, RAGE, AGEs
Introduction
Aging is defined as the progressive accumulation of damage over time, leading to disturbed function on the cellular, tissue and organ level and eventually to disease and death. Aging is a complex, multifactorial process where genetic, endogenous and environmental factors play a role.1
Skin is the largest organ of the human body and also the boundary between an organism and environment. As such, skin is subjected not only to the internal aging process but also to various external stressors, leading to distinct structural changes and affecting not only its youthful appearance, but also its various physiological functions. Aged skin shows disturbed skin permeability, angiogenesis, lipid and sweat production, immune function and vitamin D synthesis, manifesting among others as impaired wound healing, atrophy, vulnerability to external stimuli and development of several benign and malignant diseases (reviewed in Zouboulis et al.).2
Endogenously aged skin refers to changes reflecting the internal aging process of the organism and is being observed mainly in ultraviolet (UV) light-protected skin areas, such as the inner side of the arms. Macroscopically it is recognized by fine wrinkles, loss of elasticity, reduced epidermal and dermal thickness, while microscopically epidermal atrophy, decreased mitotic rate of basal keratinocytes, decreased proliferative capacity and cellular senescence, atrophy of the dermal extracellular matrix and change of the physiological properties of the connective tissue are typical characteristics.2–4 Exogenously aged skin or photoaged skin is the skin where endogenous aging processes are being aggravated by external stressors, mainly UV irradiation,2,5 but also by tobacco,6 chemicals and pollution.2,4 Apart from many similarities with endogenously aged skin, extrinsic aged skin is also characterized by a thickened epidermis and a hyperplasia of elastic tissue (solar elastosis).2,4
Until today, more than 300 theories of aging have been proposed, among them the theory of cellular senescence, decreased proliferative capacity and telomere shortening, mitochondrial DNA single mutations, the free radical theory and others, none of which can fully explain all changes observed in aging.7–11 According to the inflammatory theory of aging, a common characteristic of skin aging factors is their ability to induce or maintain proinflammatory changes and trigger a local inflammatory response which through subsequent immune responses, matrix metalloproteinase (MMP) activation and proinflammatory cytokine production contributes to the structural changes observed in aged skin.12
In the recent years, the role of advanced glycation end products (AGEs) has been increasingly discussed in skin aging, and the potential of anti-AGE strategies has received high interest from pharmaceutical companies for the development of novel anti-aging cosmeceutical compounds.
The aim of this work is to critically review the existing literature on AGEs and provide evidence that they play an important role in the pathogenesis of skin aging. Furthermore, existing and potential strategies against the deleterious effects of AGEs on skin aging will be discussed.
Biochemistry of AGEs
Glycation is the non-enzymatic reaction between reducing sugars, such as glucose, and proteins, lipids or nucleic acids.13 Glycation has to be distinguished from glycosylation, which is an enzymatic reaction. Since its first description by Maillard in 1912 and its involvement in food browning during thermal processing by Hodge 50 years later, its presence in living systems and involvement in various pathologies of the human body, including aging and diabetes, have been an intensive field of research.14,15
Formation of AGEs is a complicated molecular process involving simple and more complex multistep reactions. During the classical Maillard reaction electrophilic carbonyl groups of glucose or other reactive sugars react with free amino groups of amino acids (especially of basic lysine or arginine residues), forming a non-stable Schiff base.16 Further rearrangement leads to formation of a more stable ketoamine (Amadori product) (Fig. 1).13,16 Schiff bases and Amadori products are reversible reaction products. However, they can react irreversibly with amino acid residues of peptides or proteins to form protein adducts or protein crosslinks.13,16 Alternatively, they can undergo further oxidation, dehydration, polymerization and oxidative breakdown reactions to give rise to numerous other AGEs.13,17 Oxygen, reactive oxygen species (ROS) and redox active transition metals accelerate AGE formation. When an oxidative step is involved, the products are called advanced glycoxidation end products.13,17
Figure 1. Schematic presentation of the Maillard reaction. Reactive carbonyl groups of a reducing sugar react with neutrophilic free amino groups of proteins to form a reversible Schiff base. Through rearrangement a more stable Amadori product is formed. Dependent on the nature of these early glycation end products, protein adducts or protein crosslinks are formed.
AGEs are a very heterogeneous group of molecules. Since the discovery of the first glycated protein, glycated hemoglobin in diabetes, numerous other AGEs have been detected. Some of them have characteristic autofluorescent properties, which simplifies their identification in situ or in vivo.13 To date, numerous AGEs have been identified. Table 1 lists the most commonly found ones in the skin.17–28
Table 1. Detected AGEs in skin*
Carboxymethyl-lysine (CML) was first described by Ahmed and represents the most prevalent AGE in vivo.29,30 It is a non-fluorescent protein adduct. Mechanisms of its formation include oxidative degradation of Amadori products or direct addition of glyoxal to lysine. It seems to be the major epitope of the commonly used polyclonal anti-AGE antibodies.30
Pentosidine was first isolated and characterized by Sell and Monnier. It is composed of an arginine and a lysine residue crosslinked to a pentose.31 Pentosidine is a fluorescent glycoxidation product and forms protein-protein crosslinks.16
Dicarbonyl compounds like 3-deoxyglucosome, methylglyoxal and glyoxal derive from oxidative degradation or autooxidation of Amadori products and other pathways.13,32 These dicarbonyl compounds are very reactive molecules leading to protein crosslinks.13 Other in vivo characterized AGEs include glucosepane, carboxymethyl-hydroxy-lysine, carboxyethyl-lysine (CEL), fructose-lysine, methylglyoxal-derived hydroimidazolones and pyrraline, which form non-fluorescent protein adducts, while glyoxal-lysine dimer (GOLD) and methylglyoxal-lysine dimer (MOLD) form non-fluorescent protein crosslinks.13,17
AGEs can be exogenously ingested (through food consumption) or be endogenously produced. Endogenous AGE formation is increased in diabetes; however, AGEs are also formed at lower rates by normal metabolic processes of the organism.33 Environmental factors, such as diet and smoking influence the rate of AGE formation.34 Moreover, it seems that the level of circulating AGEs levels are genetically determined, as shown in a cohort study of healthy monozygotic and heterozygotic twins.35
The content of AGEs in the organism is not only defined by the rate of their formation but also by the rate of their removal. Many cells have developed intrinsic detoxifying pathways against accumulation of AGEs.36 The glutathione-dependent glyoxalase system, comprising of glyoxalase (Glo) I and II, has a key role in the defense against glycation.37 This system uses reduced glutathione (GSH) to catalyze the conversion of glyoxal, methylglyoxal and other α-oxoaldehydes to the less toxic D-lactate.37 Other enzymatic systems include fructosyl-amine oxidases (FAOXs) and fructosamine kinases, relatively new classes of enzymes which recognize and break Amadori products.38 However, FAOXs or “amadoriases” have been found to be expressed only in bacteria, yeast and fungi but not in mammals. They oxidatively break Amadori products but act mostly on low molecular weight compounds.39 On the contrary, fructosamine kinases are expressed in various genomes including humans.38 These intracellular enzymes phosphorylate and destabilize Amadori products leading to their spontaneous breakdown.39Fructosamine-3-kinase (FN3K), one of the most studied enzymes in this system, is almost ubiquitary expressed in human tissues including the skin. Thus, it plays an important role in the intracellular breakdown of Amadori products.40
Receptors for AGEs
AGEs not only exert their deleterious actions due to their biological properties per se, but also through their interaction with specific receptors. Receptor for AGEs (RAGE) is a multiligand member of the immunoglobulin superfamily of cell surface receptors, encoded by a gene on chromosome 6 near the major histocompatibility complex III. It is a pattern recognition receptor binding in addition to AGEs various other molecules such as S-100/calgranulins, high motility group protein B1 (amphoterine), β-amyloid peptides and β-sheet fibrils.33,41 The binding of ligands to RAGE stimulates various signaling pathways including the mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinases (ERK) 1 and 2, phosphatidyl-inositol 3 kinase, p21Ras, stress-activated protein kinase/c-Jun-N-terminal kinase and the janus kinases.33,41 Stimulation of RAGE results in activation of the transcription factor nuclear factor kappa-B (NFκB) and subsequent transcription of many proinflammatory genes.41,42Interestingly, RAGE-induced activation of NFκB is characterized by a sustained and self-perpetuating action, through induction of positive feedback loops and overwhelming of the autoregulatory negative feedback loops. RAGE activation leads to new synthesis of the transcriptionally active subunit p65, which overwhelms the newly synthesized inhibitor IκBα. Moreover NFκB increases further expression of RAGE, which itself further stimulates NFκB, forming a vicious cycle of self-renewing and perpetuating proinflammatory signals.41 RAGE activation can directly induce oxidative stress by activating nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase (NOX), decreasing activity of superoxide dismutase (SOD), catalase and other pathways, and indirectly by reducing cellular antioxidant defenses, like GSH and ascorbic acid.41,43,44 The reduction of GSH leads furthermore to decreased activity of Glo I, the major cellular defense system against methylglyoxal, therefore supporting further production of AGEs.37 RAGE is almost ubiquitary expressed in the organism, typically at low levels, and its expression is upregulated under various pathologic conditions.41,45 In the skin, RAGE expression was observed in both epidermis and dermis, and it was increased in sun-exposed compared with UV irradiation-protected areas. Keratinocytes, fibroblasts, dendritic cells and to a lesser extent endothelial cells and lymphocytes express RAGE.45 Not only in vivo, but also in vitro, various skin cells types have been shown to express RAGE (Table 2).43,45–51
Table 2. Expression of human RAGE in skin and skin cells*
RAGE is the most studied receptor for advanced glycation end products. Another group of cell surface receptors, AGER1, AGER2 and AGER3 seem to regulate endocytosis and degradation of AGEs, thus counteracting the effects of RAGE.52 AGER1 has been further shown to counteract AGEs-induced oxidative stress via inhibition of RAGE signaling.53,54 Soluble RAGE (sRAGE) is a truncated splice variant of RAGE containing the ligand-binding domain but not the transmembrane domain and has been found in plasma. sRAGE is a soluble extracellular protein without signaling properties and it is considered as a natural decoy receptor of RAGE.55
Role of AGEs During Skin Aging
Cutaneous accumulation of AGEs is a feature of skin aging
As mentioned above, AGEs can be directly formed in the organism or be exogenously ingested. Accumulation of AGEs has been detected in various tissues during aging and diabetes, including articular collagen, skeletal and smooth vascular muscles or glomerular basement membranes.56–58 Accordingly, deposited AGEs in these tissues have been implicated in various diabetes- or age-associated pathologies such as diabetic angiopathy, age- and diabetes-associated macular degeneration and osteoarthritis.56–62
Skin, due to its easy accessibility, offers an excellent opportunity for minimal invasive or even non-invasive investigation of glycation, taking advantage of the characteristic autofluorescent properties of AGEs. Accumulation of AGEs in the skin has been therefore thoroughly studied and is detected not only in diabetes as expected but also during chronological aging.20,63,64 Glycation-associated skin autofluorescence was shown to correlate with chronological aging in a large number of healthy subjects.65
It is a general perception today that AGE accumulation is dependent on protein turnover rate; therefore long-lived proteins are thought to be mainly modified by glycation.66 Collagen types I and IV, exhibiting a slow turnover rate of about 10 y, and other dermal long-lived proteins like fibronectin mainly suffer from glycation during intrinsic chronological aging.19,20 The appearance of glycated collagen is first observed at the age of 20. It accumulates with a yearly rate of about 3,7% reaching a 30–50% increase at 80 y of age.20,67 CML was recently histochemically detected in human epidermis from healthy donors.18 The upper epidermal layers were mostly involved (stratum spinosum, granulosum and corneum) and the authors identified cytokeratin 10 (CK10) (expressed by differentiated keratinocytes) as a target protein for CML modification. The amount of CML in younger donors seemed to be weak in comparison to the older ones. The latter study had restrictions, as the size of the sample was small and heterogeneous, but indicates a potential involvement of AGEs in epidermal physiology and a possible involvement of more short-lived proteins in glycation chemistry. Moreover, in an in vitro reconstructed organ skin model, both epidermis and dermis, as well as their functions, were modified by glycation.68
AGEs also seem to highly accumulate in extrinsically aged skin. Until now, the deleterious effects of UV irradiation have been mainly attributed to proinflammatory changes, apoptosis, oxidative damage, mutagenesis and induction of MMPs.2,5 However, it has been shown that in young individuals, where typically no significant accumulation of AGEs in sun-protected skin is observed, sun-exposed areas display an increased deposition of these substances.20,69 Accumulation of AGEs was mainly found in sites of solar elastosis in sun-exposed skin, showing that UV irradiation may also precipitate the formation of AGEs in vivo.20,23 It is tempting to speculate that formation of AGEs in sun-exposed skin may be one additional mechanism mediating the various structural and functional modifications during photoaging.
Moreover, smoking, a typical aggravating factor of skin aging, accelerates formation of AGEs and increases their deposition in various tissues including skin.70,71 Another important environmental factor for aging is diet. The content of AGEs in food is highly dependent on the method of preparation, like cooking time and temperature. Fried food contains in general far higher amounts of AGEs than boiled or steamed food.72 Approximately 10–30% of ingested AGEs are absorbed in the circulation.73 Dietary AGEs directly correlate with serum levels of AGEs and inflammatory markers in healthy human subjects, respectively.73
It has been widely accepted that AGEs, once formed, can be only removed when the modified proteins degrade. However it has now become apparent that in the organism various enzymatic systems seem to be involved in the degradation or removal of AGEs. As mentioned above, Glo I is an enzyme responsible for the removal of reactive α-dicarbonyl compounds. Interestingly, decreased activity of such defense systems against AGEs has been reported during aging.44 These age-related changes may further increase the extent of deposited AGEs in a living organism over time.
Consequences of AGE deposition in skin
AGEs can be formed intracellularly and extracellularly. Their presence in biological molecules modifies their biomechanical and functional properties. Proteins, lipids and nucleic acids can be targets of advanced glycation, modifying enzyme-substrate interactions, protein-DNA interactions, protein-protein interactions, DNA regulation and epigenetic modulation, thus interfering with numerous physiological functions of the organism. Moreover, AGEs are themselves reactive molecules which through interaction with their receptors activate various molecular pathways in vivo, thus becoming involved in inflammation, immune response, cell proliferation and gene expression (Fig. 2).
Figure 2. Effects of AGEs on skin. AGEs are formed intracellularly and extracellularly. They can react with proteins, lipids and nucleic acids in almost all skin cells as well as on intracellular or extracellular proteins. Through alteration of the physicochemical properties of dermal proteins, decreased cell proliferation, increased apoptosis and senescence, induction of oxidative stress and proinflammatory mediators as well as other pathways, AGEs contribute to the overall picture of skin aging. Triangles represent AGEs. Abbreviations: jak/stat, januskinase/signal transducers and activators of transcription; MCP-1, monocyte chemotactic protein-1; all other abbreviations are already explained in the text.
1. Extracellular matrix proteins
Extracellular matrix (ECM) proteins have been regarded as one of the major target structures for glycation. The most abundant collagen type in the skin is type I, whereas collagen IV is being found in the basal membrane. Collagen is one of the strongest proteins. In the skin, it is not only used as a supportive framework for mechanical support for cells and tissues, but represents an active component being able to interact with cells and affect various cellular functions such as migration, differentiation and proliferation.
Collagen glycation impairs its function in various ways. Intermolecular crosslinks of adjacent collagen fibers change its biomechanical properties leading to stiffness and decreased flexibility, thus increasing its susceptibility to mechanical stimuli.74 The change of its charge and the formation of AGEs on side chains of collagen affect its contact sites with cells and other matrix proteins and inhibit its ability to react with them.75 The precise aggregation of monomers into the triple helix may be affected as well as the association of collagen IV with laminin in the basal membrane.16 Modified collagen resists degradation by MMPs, thus inhibiting its removal and replacement by newly synthesized and functional one.62Accordingly, tissue permeability and turnover is impaired.16,76
Other extracellular matrix proteins suffering from advanced glycation are elastin and fibronectin, contributing further to dermal dysfunction.19,20,23 Of note, CML-modified elastin has been found almost exclusively in sites of actinic elastosis and not in sun-protected skin, underlining its potential role in photoaging. Indeed, UV irradiation stimulates glycation of elastin in the presence of sugars. Moreover, CML-modified elastin assembled in large and irregular structures, has decreased elasticity and is resistant to proteolytic degradation.77
It has been shown that in vitro glycated skin samples have impaired biomechanical properties.78 In vivo, decreased skin elasticity characterizes diabetic subjects in comparison to healthy controls.79
2. Intracellular proteins
Intermediate filaments such as vimentin in fibroblasts and CK10 in keratinocytes have been found to be modified by AGEs.18,22 Cytoskeletal proteins are important in providing stability of the cytoskeleton and are crucially involved in numerous cellular functions such as migration and cellular division. Various other intracellular proteins including enzymes and growth factors may be targets of non-enzymatic modification by sugars. Glycated basic fibroblast growth factor (bFGF) displays impaired mitogenic activity in endothelial cells.80 Glycation of enzymes of the ubiquitin-proteasome system and of the lysosomal proteolytic system has been shown to inhibit their action.81 Antioxidant and other protective enzymes such as Cu-Zn-SOD can be inactivated.82 Other intracellular components, such as DNA and lipids can be glycated with detrimental effects on their function.13,83
3. Receptors for AGEs: RAGE
AGEs do not only act by altering the physicochemical properties of glycated proteins. Interestingly, AGEs may bind to their cell surface receptor, RAGE, initiating a cascade of signals influencing cell cycle and proliferation, gene expression, inflammation and extracellular matrix synthesis (reviewed in Bierhaus et al.).41 As mentioned above, RAGE is broadly expressed in human skin and in epidermal keratinocytes, dermal fibroblasts and endothelial cells in vitro. It is highly found in sites of solar elastosis, and its expression is induced by advanced glycation end products and proinflammatory cytokines like TNFα.45 In skin cells RAGE has been shown to decrease cell proliferation, induce apoptosis and increase MMPs production.47 Many of these effects involve NFκB signaling.47
4. Effects of AGEs on resident skin cells
AGEs have been shown to affect various functions of skin cells in vitro (Table 3). They decrease proliferation and enhance apoptosis of human dermal fibroblasts, an effect which is at least partly RAGE-dependent and correlates with the activation of NFκB and caspases.87 In keratinocytes, AGEs decrease cell viability and migration and induce the expression of proinflammatory mediators.84 Moreover, AGEs are able to induce premature senescence in human dermal fibroblasts and in normal human keratinocytes in vitro.86,89,90 Collagen and ECM protein synthesis have been also found to be decreased, while the expression of MMPs is induced.47 Dicarbonyls such as glyoxal and methylglyoxal impair the signaling of epidermal growth factor receptor (EGFR), a receptor controlling various cellular functions such as proliferation, differentiation, motility and survival, by formation of EGFR crosslinks, blocking of phosphorylation and impaired activation of ERKs and phospholipase C.92 Various other growth factors or proteins significant for cellular functions, like bFGF, may be glycated inhibiting their functions.80 In the context of extrinsic aging, AGEs seem to render cells more sensitive to external stimuli, as UVA irradiated fibroblasts and keratinocytes exhibit decreased viability after exposure to AGEs.85,93
Table 3. Effects of AGEs/RAGE on skin morphology and physiology during aging*
5. The role of oxidative stress
Oxidative stress has been widely accepted to mediate the deleterious effects of solar radiation in the skin during photoaging. Interestingly, in vitro exposure of AGEs to UVA irradiation leads to formation of ROS, such as superoxide anion, hydrogen peroxide and hydroxyl radicals.93 AGEs can lead to ROS formation in cells by various ways. They can stimulate NOX to induce production of superoxide anion or they can compromise cellular antioxidant defense systems, e.g. inactivation of Cu-Zn-SOD by cross-linking and site-specific fragmentation of this molecule.82 Moreover, AGEs are themselves very reactive molecules. As early as during their crosslinking reactions they can act as electron donors leading to formation of superoxide anions.94 Glycation of proteins creates active enzyme-like centers (cation-radical sites of crosslinked proteins) able to catalyze one-electron oxidation-reduction reactions leading to ROS generation with or without presence of oxygen or transition metals such as iron and copper.94-,96
Finally, autofluorescent AGEs, such as pentosidine, can act as endogenous photosensitizers leading to increased ROS formation after UVA irradiation of human skin.97 UV irradiation of human keratinocytes and fibroblasts in the presence of AGEs led to increased ROS formation and decreased proliferation in vitro.85
6. Skin AGEs as biomarkers of aging
As AGEs have been etiologically implicated in aging and aging-related pathologies, the idea of using them as biomarkers is appealing. AGEs in the skin have been initially measured by western blots (WB) with polyclonal antibodies or by autofluorescence measurements of skin biopsies, thus restricting the wide use of these measurements. An AGE-Reader (DiagnOptics B.V., Groningen, The Netherlands) has been introduced some years ago as a new, non-invasive method to measure in vivo the skin content of AGEs based on their characteristic autofluorescence.98–100
Until now it has been shown that skin autofluorescence positively correlates with various diabetes- and age-related complications such as micro- and macrovascular complications, renal disease, cardiovascular events, overall mortality, age-related macular degeneration and chronic renal disease.99,101,102 Skin glycation has been proposed as a prognostic factor for the development of diabetic complications.103Lately it was shown that skin autofluorescence increases with chronological aging and correlates with skin deposition of AGEs, making this method a potential tool in investigating the effect of various anti-aging products of the cosmetic industry.104
Anti-AGE Strategies: Current Knowledge and Future Perspectives
Since the emergence of AGEs as an important pathogenetic factor in diabetes and aging the development of strategies against AGEs has been in the center of scientific interest. Substances able to prevent or inhibit formation of AGEs, as well as agents able to break already formed AGEs or those antagonizing their signaling have been identified. Some of them are already being tested in clinical trials.105,106
1. Substances preventing or inhibiting AGE formation
Aminoguanidine was one of the first substances identified limiting the formation of AGEs.107Aminoguanidine is a nucleophilic hydrazine and its anti-AGE properties result from trapping of early glycation products such as carbonyl intermediate compounds. It has no effects on more advanced stages of glycation. Despite its potential effects in attenuating various diabetes- and age-related complications in animal models, its use in clinical practice is limited due to adverse effects in clinical trials with diabetic patients.108 In an in vitro skin aging model it could attenuate collagen glycation, however its effects against AGE-induced collagen modification in vivo have been contradictory.109–111 Studies on topical application of aminoguanidine in the skin are lacking.
Pyridoxamine, a naturally occurring vitamin B6 isoform, seems to be another tool in the fight against AGEs. Pyridoxamine traps reactive carbonyl intermediates, scavenges ROS and in addition inhibits post-Amadori stages of AGEs formation.112 It has shown promising results in a phase II clinical trial against diabetic nephropathy.113 Oral intake of pyridoxamine resulted in potent inhibition of skin collagen CML formation in diabetic rats.111 However, its potential against skin aging remains to be shown.
2. “AGE breakers”
Chemical substances and enzymes able to recognize and break the Maillard reaction crosslinks have been identified. Such chemical AGE breakers are dimethyl-3-phenayl-thiazolium chloride (ALT-711), N-phenacylthiazolium and N-phenacyl-4,5-dimethylthiazolium.113 They have been developed to chemically break the prototypical Maillard reaction crosslink via a thiazolium structure.113 Promising results against cardiovascular complications in diabetes and aging have been reported, although their actual ability to cleave existing protein crosslinks in tissues has been questioned.114–117 In the rat ALT-711 showed some promising results on skin hydration.113
Interference with intrinsic AGE-detoxifying enzymes like FAOXs, FN3K and the enzymatic system of Glo is another interesting strategy to remove AGEs, as enzymes recognize specific substrates and may be associated with fewer side effects.37,38,118 There are a lot of data supporting the significance of these enzyme systems in aging. As noted above decreased Glo I activity and increased accumulation of AGEs with age have been shown in many tissues and animals.37 Overexpression of Glo I significantly inhibits hyperglycemia-induced intracellular formation of AGEs in bovine aortic endothelial cells and in mouse mesangial cells by reduction of intracellular oxidative stress and apoptosis.119,120 A potential in vivo beneficial effect of Glo I against AGEs could be also shown in transgenic rats.121 Interestingly, it has been recently shown that Glo I is transcriptionally controlled by Nrf2, and that pharmacological Nrf2 activators increase Glo I mRNA and protein levels as well as its activity.122 The pharmacological induction of such enzymes could represent a novel future strategy against AGEs. Fructosamine phosphokinases are relatively new enzymes and currently under investigation, and until now no inductors or activators of their expression have been found.40 FAOXs on the other hand are not expressed in mammals, and their potential use in humans by enzymatic engineering remains to be discovered.39
3. Nutriceuticals
Since oxidation steps are crucially involved in formation of many AGEs, substances with antioxidative or metal chelating properties, may also have antiglycating activities.123 Thus, a lot of interest has been directed to nutrients and vitamins, so called “nutriceuticals,” as natural tools against AGEs.106,124
Accordingly, an increasing list of natural antioxidants and chelating agents such as ascorbic acid, α-tocopherol, niacinamide, pyridoxal, sodium selenite, selenium yeast, trolox, rivoflavin, zink and manganese has been shown to inhibit glycation of albumin in vitro.125 Alpha-lipoic acid was able to reverse tail tendon collagen glycation in fructose-fed rats, an effect which was attributed to its endogenous antioxidant action, its ability to recycle ascorbic acid, α-tocopherol and GSH as well as to its positive influence on glucose uptake and glycaemia.126 Green tea, vitamins C and E and a combination of N-acetylcystein with taurine and oxerutin could inhibit skin collagen glycation in mice.124,127 Another compound, the green tea-derived polyphenol and flavonoid epigallocatechin-3-gallate revealed also promising in vitro effects by antagonizing AGE-induced proinflammatory changes.128 In healthy human subjects, supplementation of vitamin C significantly decreased serum protein glycation.129
Many spices and herbs were shown to inhibit glycation of albumin in vitro, among them ginger, cinnamon, cloves, marjoram, rosemary and tarragon.130 Their protective effects correlated with their phenolic content. Recently, in vivo beneficial effects of some of these compounds were shown in zebrafish.131
Other promising compounds include blueberry extract and naturally occurring flavonoids, such as luteolin, quercetin and rutin, which can inhibit various stages of AGE formation.132,133 Recently, blueberry extract, an AGE-inhibitor and C-xyloside, a glycosaminoglycan synthesis stimulator, were tested for 12 weeks in female diabetic subjects. This treatment resulted in significant improvement of skin firmness, wrinkles and hydration although it failed to show a significant decrease in the cutaneous content of AGEs.132
4. Caloric restriction and dietary measures
As nutrition is an important factor in skin aging, dietary caloric restriction may be effective in preventing accumulation of AGEs in the human body. In mice restriction of caloric intake increases lifespan and delays many age-related dysfunctions by altering stress response and influencing the expression of various metabolic and biosynthetic genes.134 Dietary restriction could significantly decrease the levels of AGEs in rat and mice skin collagen.135,136 Skin collagen glycation and glycoxidation inversely correlated with lifespan whereas caloric restriction led to decreased accumulation of AGEs and increased lifespan.137Dietary restriction may not be a pragmatic option in humans; however a restriction in intake of dietary “glycotoxins” may be more feasible. As outlined above these dietary glycotoxins derive from nutrition. In humans dietary glycotoxins significantly increase concentrations of systemic inflammatory mediators like TNFα, interleukin (IL)-6 and C-reactive protein and are thus considered as diabetogenic, nephrotoxic and proatherogenic.59,138,139 Dietary intake of AGEs correlates with serum AGEs and can induce systemic oxidative stress, increase RAGE expression, decrease antioxidant levels and shorten lifespan in mice.54 A diet with a low content in AGEs could reduce circulating AGEs and inflammatory biomarkers in patients with diabetes and renal failure thus seeming to be an important supportive therapy in diabetes.140,141 In mice low dietary AGEs had beneficial effects in wound healing and other diabetes mellitus-associated pathologies.142 There are no studies investigating the effects of AGE-poor diets on skin aging in humans. However, it has been shown that skin collagen glycation positively correlates with blood glucose levels in diabetes and that intensive treatment can reduce the levels of skin glycation, implicating that a diet low in AGEs may have a beneficial effect on skin glycation.143,144
5. Targeting RAGE
Another potential strategy against excessive accumulation of AGEs could be the antagonism of RAGE.145Possible approaches include gene knock-down of RAGE by siRNA or anti-sense and antagonism of RAGE with putative small molecular inhibitors against RAGE-induced signaling.50,145 Promising effects in various systems have been shown in vitro and in vivo with neutralizing anti-RAGE antibodies.41 Since serum concentrations of sRAGE negatively correlate with AGE-induced pathologies, neutralization of AGEs by these decoy receptors of RAGE may be considered as another potential anti-AGE strategy. Potential protective effects of sRAGE have been shown in various diabetes and inflammatory models.41,44,45,146Interestingly, sRAGE could also attenuate impaired wound healing in diabetic mice. Therefore, studies will be needed to investigate an analogous effect on skin aging.147
6. Others
Molecular chaperones like carnosine have lately shown promise in improving skin appearance in various studies at least in part by reducing the amounts of skin AGEs.148–150
Conclusion
There is ample evidence that AGEs play an important role in skin aging. There are also numerous studies investigating potential substances against excessive accumulation of AGEs in tissues. Some of these studies have already shown protective effects against diabetic complications. As controlled human studies investigating the effects of these anti-AGE strategies against skin aging are largely missing, this is a hot field for future research.
SCIENTIFIC STUDIES:
- Increase in the Advanced Glycation end product pentosidine in Bruch’s membrane with age.
- Chelating activity of Advanced Glycation end-product inhibitors
- The Advanced Glycation end product , N∊-(carboxymethyl) lysine, is a product of both lipid peroxidation and glycoxidation reactions
- Advanced Glycation end product interventions reduce diabetes-accelerated atherosclerosis
- Recent progress in Advanced Glycation and diabetic vascular disease: role of Advanced Glycation end product receptors
- Improved arterial compliance by a novel Advanced Glycation end-product crosslink breaker
- Plasma levels of pentosidine in diabetic patients: an Advanced Glycation end product .
- The effect of Advanced Glycation end-product formation upon cell-matrix interactions
- Advanced Glycation end product ligands for the receptor for Advanced Glycation end products : biochemical characterization and formation kinetics
- Reaction of metformin with dicarbonyl compounds. Possible implication in the inhibition of Advanced Glycation end product formation
- Immunological detection of a novel Advanced Glycation end-product
- Advanced Glycation end product Cross‐Linking: Pathophysiologic Role and Therapeutic Target in Cardiovascular Disease
- Advanced Glycation end product recognition by the receptor for AGEs
- Dietary glycotoxins correlate with circulating Advanced Glycation end product levels in renal failure patients
- Therapeutic potential of breakers of Advanced Glycation end product –protein crosslinks
- High serum level of pentosidine, an Advanced Glycation end product (AGE) , is a risk factor of patients with heart failure
- Inhibitors of Advanced Glycation end product formation and neurovascular dysfunction in experimental diabetes
- Effect of Advanced Glycation end product intake on inflammation and aging: a systematic review
- N. epsilon.-(Carboxymethyl) lysine is a dominant Advanced Glycation end product (AGE) antigen in tissue proteins
- Advanced Glycation end product receptor‐mediated cellular dysfunction
- Immunohistochemical detection of imidazolone, a novel Advanced Glycation end product , in kidneys and aortas of diabetic patients.
- Advanced Glycation end product -induced activation of NF-κB is suppressed by α-lipoic acid in cultured endothelial cells
- Advanced Glycation end product level, diabetes, and accelerated cognitive aging
- Clearance of pentosidine, an Advanced Glycation end product , by different modalities of renal replacement therapy
- Advanced Glycation end-product cross-link breakers: a novel approach to cardiovascular pathologies related to the aging process
- Advanced Glycation end product precursors impair epidermal growth factor receptor signaling
- ELISA of pentosidine, an Advanced Glycation end product , in biological specimens
- Inhibition of Advanced Glycation end product formation on collagen by rutin and its metabolites
- Oxidative stress, Advanced Glycation end product , and coronary artery calcification in hemodialysis patients
- Glucosepane: a poorly understood Advanced Glycation end product of growing importance for diabetes and its complications
- … transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel Advanced Glycation end product inhibitor, OPB-9195
- Advanced Glycation end product modification of bone proteins and bone remodelling: hypothesis and preliminary immunohistochemical findings
- Advanced Glycation end product accumulation: a new enemy to target in chronic kidney disease?
- … and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and Advanced Glycation end product …
- Increased pentosidine, an Advanced Glycation end product , in plasma and synovial fluid from patients with rheumatoid arthritis and its relation with inflammatory …
- Skin Advanced Glycation end product accumulation and muscle strength among adult men
- Role of oxidative stress in Advanced Glycation end product -induced mesangial cell activation
- Characterization of the Advanced Glycation end-product receptor complex in human vascular endothelial cells
- Inhibition of NADPH oxidase prevents Advanced Glycation end product –mediated damage in diabetic nephropathy through a protein kinase C-α–dependent pathway
- Advanced Glycation end product (AGE) –mediated induction of tissue factor in cultured endothelial cells Is dependent on RAGE
- Significance of fructose-induced protein oxidation and formation of Advanced Glycation end product
- Advanced Glycation end product -induced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in …
- Glycationand Advanced Glycation end-product formation with icodextrin and dextrose
- Identification of Nω-carboxymethylarginine as a novel acid-labile Advanced Glycation end product in collagen
- Advanced Glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis
- Contribution of the Advanced Glycation end product pentosidine and of maturation of type I collagen to compressive biomechanical properties of human lumbar …
- Blockade of Advanced Glycation end-product formation restores ischemia-induced angiogenesis in diabetic mice
- Advanced Glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor
- … suppresses Advanced Glycation end product –induced monocyte chemoattractant protein–1 expression in mesangial cells by reducing Advanced Glycation end product …
- Role of hyperglycemia-induced Advanced Glycation end product (AGE) accumulation in atherosclerosis
- Pathological implications of receptor for Advanced Glycation end-product (AGER) gene polymorphism
- Effect of an Advanced Glycation end product -restricted diet and exercise on metabolic parameters in adult overweight men
- Advanced Glycation end product associated skin autofluorescence: a mirror of vascular function?
- Serum carboxymethyl–lysine, an Advanced Glycation end product , is associated with increased aortic pulse wave velocity in adults
- Role of the Maillard reaction in aging of tissue proteins: Advanced Glycation end product -dependent increase in imidazolium cross-links in human lens …
- Decreased endogenous secretory Advanced Glycation end product receptor in type 1 diabetic patients: its possible association with diabetic vascular complications
- Accumulation of carbonyls accelerates the formation of pentosidine, an Advanced Glycation end product : carbonyl stress in uremia.
- Dietary Advanced Glycation end-product restriction for the attenuation of insulin resistance, oxidative stress and endothelial dysfunction: a systematic review
- Role of receptor for Advanced Glycation end-products and signalling events in Advanced Glycation end-product-induced monocyte chemoattractant protein-1 …
- Genistein inhibits Advanced Glycation end product formation by trapping methylglyoxal
- Connective tissue growth factor plays an important role in Advanced Glycation end product –induced tubular epithelial-to-mesenchymal transition: implications for …
- Prevention of diabetic vascular dysfunction by guanidines: inhibition of nitric oxide synthase versus Advanced Glycation end-product formation
- Tissue-Advanced Glycation end product concentration in dialysis patients
- Inhibition of Advanced Glycation end product formation by medicinal plant extracts correlates with phenolic metabolites and antioxidant activity
- Role of receptor for Advanced Glycation end‐product (RAGE) and the JAK/STAT‐signaling pathway in AGE‐induced collagen production in NRK‐49F cells
- Advanced Glycation end product precursors impair ABCA1-dependent cholesterol removal from cells
- Skin autofluorescence, a marker for Advanced Glycation end product accumulation, is associated with arterial stiffness in patients with end-stage renal disease
- Advanced Glycation end product homeostasis: exogenous oxidants and innate defenses
- Quercetin inhibits Advanced Glycation end product formation by trapping methylglyoxal and glyoxal
- Agents that block Advanced Glycation end product (AGE) -RAGE (receptor for AGEs)-oxidative stress system: a novel therapeutic strategy for diabetic vascular …
- Advanced Glycation end-product Nɛ-carboxymethyl-Lysine accelerates progression of atherosclerotic calcification in diabetes
- Recombinant Advanced Glycation end product receptor pharmacokinetics in normal and diabetic rats
- Relationship of an Advanced Glycation end product , plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study
- Advanced Glycation end product (AGE) accumulation on Bruch’s membrane: links to age-related RPE dysfunction
- The cross-link breaker, N-phenacylthiazolium bromide prevents vascular Advanced Glycation end-product accumulation
- Argpyrimidine, a methylglyoxal-derived Advanced Glycation end-product in familial amyloidotic polyneuropathy
- Role of Advanced Glycation end product (AGE) -induced receptor (RAGE) expression in diabetic vascular complications
- Pigment epithelium-derived factor protects cultured retinal pericytes from Advanced Glycation end product -induced injury through its antioxidative properties
- Involvement of Advanced Glycation end product -induced asymmetric dimethylarginine generation in endothelial dysfunction
- Antihyperglycemic activity and inhibition of Advanced Glycation end product formation by Cuminum cyminum in streptozotocin induced diabetic rats
- ERK and Akt signaling pathways are involved in Advanced Glycation end product -induced autophagy in rat vascular smooth muscle cells
- The serum concentration of the Advanced Glycation end-product Nε-(carboxymethyl) lysine is increased in uremia
- Elevated serum levels of N ε-carboxymethyl-lysine, an Advanced Glycation end product , are associated with proliferative diabetic retinopathy and macular …
- Impact of oxidative stress biomarkers and carboxymethyllysine (an Advanced Glycation end product ) on prostate cancer: a prospective study
- Regulation of Advanced Glycation end product (AGE) receptors and apoptosis by AGEs in osteoblast-like cells
- Blockade of receptor for Advanced Glycation end product (RAGE) attenuates ischemia and reperfusion injury to the liver in mice
- Reduction of Advanced Glycation end product levels by on-line hemodiafiltration in long-term hemodialysis patients
- Advanced Glycation end-product accumulation and associated protein modification in type II skeletal muscle with aging
- Effect of Moringa oleifera on Advanced Glycation end-product formation and lipid metabolism gene expression in HepG2 cells
- The Advanced Glycation end‐product Nϵ‐carboxymethyllysine promotes progression of pancreatic cancer: implications for diabetes‐associated risk and its …
- Advanced Glycation end product (AGE) -induced proliferation of HEL cells via receptor for AGE-related signal pathways
- Pigment epithelium-derived factor inhibits Advanced Glycation end product -induced retinal vascular hyperpermeability by blocking reactive oxygen species …
- Advanced–Glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1
- The Contribution of Advanced Glycation end product (AGE) accumulation to the decline in motor function
- Effect of pseudophosphorylation and cross-linking by lipid peroxidation and Advanced Glycation end product precursors on tau aggregation and filament …
- Low Advanced Glycation end product diet improves the lipid and inflammatory profiles of prediabetic subjects
- Inhibition of Advanced Glycation end-product formation by high antioxidant-leveled spices commonly used in European cuisine
- Role of microRNA-214–targeting phosphatase and tensin homolog in Advanced Glycation end product -induced apoptosis delay in monocytes
- Advanced Glycation end product (AGE) -receptor for AGE (RAGE) signaling and up-regulation of Egr-1 in hypoxic macrophages
- Olive leaf extracts are a natural source of Advanced Glycation end product inhibitors
- Metabolization of the Advanced Glycation end product N-ε-Carboxymethyllysine (CML) by Different Probiotic E. coli Strains
- Increased receptor for Advanced Glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking
- Increased serum levels of the specific Advanced Glycation end product methylglyoxal-derived hydroimidazolone are associated with retinopathy in patients with type 2 …
- Confocal Raman microscopy can quantify Advanced Glycation end product (AGE) modifications in Bruch’s membrane leading to accurate, nondestructive prediction of …
- Implication of receptor for Advanced Glycation end product (RAGE) in pulmonary health and pathophysiology
- Receptor for Advanced Glycation end product (RAGE) upregulation in human gingival fibroblasts incubated with nornicotine
- Clinical studies of Advanced Glycation end product inhibitors and diabetic kidney disease
- Methylglyoxal induces Advanced Glycation end product (AGEs)formation and dysfunction of PDGF receptor‐β: implications for diabetic atherosclerosis
- Type IV collagen is transcriptionally regulated by Smad1 under Advanced Glycation end product (AGE) stimulation
- Advanced Glycation end product (AGE) modified proteins in tears of diabetic patients
- Plasma carboxymethyl‐lysine, an Advanced Glycation end product , and all‐cause and cardiovascular disease mortality in older community‐dwelling adults
- Attenuation of extracellular matrix accumulation in diabetic nephropathy by the Advanced Glycation end product cross-link breaker ALT-711 via a protein kinase C-α …
- Dietary protein intake and circulating Advanced Glycation end product /receptor for Advanced Glycation end product concentrations in the Health, Aging, and Body …
- Advanced Glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for Advanced Glycation end product -mediated activation of …
- Serum carboxymethyl-lysine, an Advanced Glycation end product , is associated with arterial stiffness in older adults
- Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing Advanced Glycation end product –receptor axis
- Combination therapy with the Advanced Glycation end product cross-link breaker, alagebrium, and angiotensin converting enzyme inhibitors in diabetes: synergy or …
- Effects of alagebrium, an Advanced Glycation end‐product breaker, in patients with chronic heart failure: study design and baseline characteristics of the BENEFICIAL …
- Anti-inflammatory effects of the Advanced Glycation end product inhibitor LR-90 in human monocytes
- Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma Advanced Glycation end-product levels
- Ability of resveratrol to inhibit Advanced Glycation end product formation and carbohydrate-hydrolyzing enzyme activity, and to conjugate methylglyoxal
- Fat mass is inversely associated with serum carboxymethyl-lysine, an Advanced Glycation end product , in adults
- Receptor for Advanced Glycation end product -dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-β-mediated cortical synaptic …
- COX‐2 and iNOS are critical in Advanced Glycation end product ‐activated chondrocytes in vitro
- Mdia1 is crucial for Advanced Glycation end product -induced endothelial hyperpermeability
- Potential clinical utility of Advanced Glycation end product cross-link breakers in age-and diabetes-associated disorders
- … effect of OPB-9195 [(±)-2-isopropylidenehydrazono-4-oxo-thiazolidin-5-ylacetanilide] on Advanced Glycation end product and Advancedlipoxidation end product …
- Mangostanaxanthones III and IV: Advanced Glycation end-product inhibitors from the pericarp of Garcinia mangostana
- Inhibition of protein glycoxidation and Advanced Glycation end-product formation by barnyard millet (Echinochloa frumentacea) phenolics
- Effect of metformin administration on plasma Advanced Glycation end product levels in women with polycystic ovary syndrome
- Increased pentosidine, an Advanced Glycation end product , in serum and synovial fluid from patients with knee osteoarthritis and its relation with cartilage oligomeric …
- Diphlorethohydroxycarmalol attenuates methylglyoxal-induced oxidative stress and Advanced Glycation end product formation in human kidney cells
- Glucagon-like peptide-1 protects hippocampal neurons against Advanced Glycation end product -induced tau hyperphosphorylation
- Green tea polyphenol epigallocatechin-3-gallate inhibits Advanced Glycation end product -induced expression of tumor necrosis factor-α and matrix …
- Regulation of Advanced Glycation end product (AGE) -receptor (RAGE) system by PPAR-gamma agonists and its implication in cardiovascular disease
- Inhibition of Advanced Glycation end-product formation on eye lens protein by rutin
- Inhibition of Advanced Glycation end product formation by cymene–A common food constituent
- Relationship between Advanced Glycation end‐product accumulation and low skeletal muscle mass in Japanese men and women
- Nε-(Carboxymethyl)lysine-Receptor for Advanced Glycation end product Axis Is a Key Modulator of Obesity-Induced Dysregulation of Adipokine Expression and …
- Advanced Glycation end product accumulation is associated with low skeletal muscle mass, weak muscle strength, and reduced bone density: the Nagahama Study
- Soluble receptor for Advanced Glycation end product : a biomarker for acute coronary syndrome
- Dietary intake associated with serum versus urinary carboxymethyl-lysine, a major Advanced Glycation end product , in adults: the Energetics Study
- Anti-Advanced Glycation end-product and free radical scavenging activity of plants from the Yucatecan flora
- Beneficial effect of Corni Fructus, a constituent of Hachimi-jio-gan, on Advanced Glycation end-product-mediated renal injury in streptozotocin-treated diabetic rats
- Advanced Glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling
- Increased concentration of pentosidine, an Advanced Glycation end product , and interleukin-6 in the vitreous of patients with proliferative diabetic retinopathy
- … dimethylarginine generation in the kidney of Streptozotocin-induced diabetic rats by blocking Advanced Glycation end product –induced protein arginine …
- Advanced Glycation end-product (AGE) -damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis
- Molecular basis of maillard amide-Advanced Glycation end product (AGE) formation in vivo
- Accumulation of argpyrimidine, a methylglyoxal-derived Advanced Glycation end product , increases apoptosis of lens epithelial cells both in vitro and in vivo
- Tissue Advanced Glycation end product deposition after kidney transplantation
- Sitagliptin augments protective effects of GLP-1 against Advanced Glycation end product receptor axis in endothelial cells
- Stilbene glucoside from Polygonum multiflorum Thunb.: a novel natural inhibitor of Advanced Glycation end product formation by trapping of methylglyoxal
- Role of Advanced Glycation end product receptors in the pathogenesis of diabetic retinopathy
- A comparative study of sulphated polysaccharide effects on Advanced Glycation end-product uptake and scavenger receptor class A level in macrophages
- Complement C3a, CpG oligos, and DNA/C3a complex stimulate IFN-α production in a receptor for Advanced Glycation end product -dependent manner
- Ginseng improves cognitive deficit via the RAGE/NF-κB pathway in Advanced Glycation end product -induced rats
- Long-term administration of Advanced Glycation end-product stimulates the activation of NLRP3 inflammasome and sparking the development of renal injury
- Circulating soluble receptor of Advanced Glycation end product inversely correlates with atherosclerosis in patients with chronic kidney disease
- Increased glyoxalase I levels inhibit accumulation of oxidative stress and an Advanced Glycation end product in mouse mesangial cells cultured in high glucose
- Age-related increase in an Advanced Glycation end product in penile tissue
- The Advanced Glycation end product methylglyoxal-derived hydroimidazolone-1 and early signs of atherosclerosis in childhood diabetes
- Benfotiamine alleviates diabetes-induced cerebral oxidative damage independent of Advanced Glycation end-product, tissue factor and TNF-α
- Aspirin inhibits the formation of pentosidine, a cross-linking Advanced Glycation end product , in collagen
- The Advanced Glycation end product Nepsilon-(carboxymethyl) lysine is increased in serum from children and adolescents with type 1 diabetes.
- … uptake of methylglyoxal-modified serum albumin. Competition with Advanced Glycation end product -modified serum albumin at the Advanced Glycation end product …
- Recombinant antibody color resulting from Advanced Glycation end product modifications
- Advanced Glycation end product accumulation in the cardiomyocytes of heart failure patients with and without diabetes.
- The Advanced Glycation end product pentosidine correlates to IL-6 and other relevant inflammatory markers in rheumatoid arthritis
- Pioglitazone inhibits Advanced Glycation end product -induced matrix metalloproteinases and apoptosis by suppressing the activation of MAPK and NF-κB
- Pathological roles of Advanced Glycation end product receptors SR‐A and CD36
- Pyridoxamine, an inhibitor of Advanced Glycation end product (AGE) formation ameliorates insulin resistance in obese, type 2 diabetic mice
- The neuroprotective role of metformin in Advanced Glycation end product treated human neural stem cells is AMPK-dependent
- Phase I clinical studies of the Advanced Glycation end-product (AGE) -breaker TRC4186
- Impairment of glyoxalase-1, an Advanced Glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis
- Plasma S100A12 and soluble receptor of Advanced Glycation end product levels and mortality in chronic kidney disease Stage 5 patients
- Sulforaphane inhibits Advanced Glycation end product –induced pericyte damage by reducing expression of receptor for Advanced Glycation end products
- Interactions of the Advanced Glycation end product inhibitor pyridoxamine and the antioxidant α-lipoic acid on insulin resistance in the obese Zucker rat
- AGER gene polymorphisms and soluble receptor for Advanced Glycation end product in patients with idiopathic pulmonary fibrosis
- Proteomic analysis defines altered cellular redox pathways and Advanced Glycation end-product metabolism in glomeruli of db/db diabetic mice
- Effects of scavenger receptors-1 class A stimulation on macrophage morphology and highly modified Advanced Glycation end product -protein phagocytosis
- Levels of soluble Advanced Glycation end product -receptors and other soluble serum markers as indicators of diabetic neuropathy in the foot
- The effect of an Advanced Glycation end-product crosslink breaker and exercise training on vascular function in older individuals: a randomized factorial design trial
- Diabetes impairs hippocampal function via Advanced Glycation end product mediated new neuron generation in animals with diabetes-related depression
- Siphonaxanthin, a carotenoid from green algae, suppresses Advanced Glycation end product -induced inflammatory responses
- Profiling of methylglyoxal blood metabolism and Advanced Glycation end-product proteome using a chemical probe
- Constituents with α-glucosidase and Advanced Glycation end-product formation inhibitory activities from Salvia miltiorrhiza Bge.
- Inhibition of Advanced Glycation end-product formation and antioxidant activity by extracts and polyphenols from Scutellaria alpina L. and S. altissima L.
- Are Advanced Glycation end‐product‐modified proteins of pathogenetic importance in fibromyalgia?
- The Advanced Glycation end product Nε-carboxymethyllysine is not a predictor of cardiovascular events and renal outcomes in patients with type 2 diabetic kidney …
- Advanced Glycation end product accumulation in subjects with open-angle glaucoma with and without Exfoliation
- Differential contribution of possible pattern‐recognition receptors to Advanced Glycation end product –induced cellular responses in macrophage‐like RAW264. 7 cells
- 1 h Postload Glycemia is associated with low endogenous secretory receptor for Advanced Glycation end product levels and early markers of cardiovascular disease
- The diabetic milieu modulates the Advanced Glycation end product -receptor complex in the mesangium by inducing or upregulating galectin-3 expression.
- Inhibition of Advanced Glycation end-product formation by Origanum majorana L. in vitro and in streptozotocin-induced diabetic rats
- Role of the Janus kinase (JAK)/signal transducters and activators of transcription (STAT) cascade in Advanced Glycation end-product-induced cellular mitogenesis in …
- Blockade of receptor for Advanced Glycation end product attenuates pulmonary reperfusion injury in mice
- Blockade of Advanced Glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats
- Quercetin inhibits Advanced Glycation end product formation via chelating metal ions, trapping methylglyoxal, and trapping reactive oxygen species
- Red blood cell adhesion in diabetes mellitus is mediated by Advanced Glycation end product receptor and is modulated by nitric oxide
- An expeditious synthesis of pentosidine, an Advanced Glycation end product
- Proteomic studies on receptor for Advanced Glycation end product variants in idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease
- Advanced Glycation end product receptor-1 transgenic mice are resistant to inflammation, oxidative stress, and post-injury intimal hyperplasia
- Efficacy of alogliptin, a dipeptidyl peptidase‐4 inhibitor, on glucose parameters, the activity of the Advanced Glycation end product (AGE) –receptor for AGE (RAGE) …
- An Advanced Glycation end product (AGE) -rich diet promotes Nε-carboxymethyl-lysine accumulation in the cardiac tissue and tendons of rats
- Advanced Glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake.
- Pigment epithelium-derived factor inhibits Advanced Glycation end product -elicited mesangial cell damage by blocking NF-κB activation
- The association between various smoking behaviors, cotinine biomarkers and skin autofluorescence, a marker for Advanced Glycation end product …
- Dehydroepiandrosterone administration counteracts oxidative imbalance and Advanced Glycation end product formation in type 2 diabetic patients
- Advanced Glycation end product (AGE) accumulation in the skin is associated with depression: the maastricht study
- Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice by attenuating Advanced Glycation end product -mediated neuroinflammation
- Irbesartan inhibits Advanced Glycation end product (AGE) -induced proximal tubular cell injury in vitro by suppressing receptor for AGEs (RAGE) expression
- Microglial receptor for Advanced Glycation end product -dependent signal pathway drives β-amyloid-induced synaptic depression and long-term depression …
- Receptor for Advanced Glycation end product (RAGE)-dependent modulation of early growth response-1 in hepatic ischemia/reperfusion injury
- Toxicological evaluation of Advanced Glycation end product Nε-(carboxymethyl) lysine: Acute and subacute oral toxicity studies
- Receptor for Advanced Glycation end-product antagonist reduces blood–brain barrier damage after intracerebral hemorrhage
- Angiotensin II augments Advanced Glycation end product -induced pericyte apoptosis through RAGE overexpression
- Serum‐soluble receptor for Advanced Glycation end product levels in patients with amyotrophic lateral sclerosis
- Microbiome–metabolomics analysis of the impacts of long-term dietary advanced–Glycation-end-product consumption on C57BL/6 mouse fecal microbiota and …
- Mutagenesis and Repair Induced by the DNA Advanced Glycation end product N2-1-(Carboxyethyl)-2′-deoxyguanosine in Human Cells
- Advanced Glycation end-product 2 and Porphyromonas gingivalis lipopolysaccharide increase sclerostin expression in mouse osteocyte-like cells
- A novel monoclonal antibody targeting carboxymethyllysine, an Advanced Glycation end product in atherosclerosis and pancreatic cancer
- Autoantibody against N (epsilon)-(carboxymethyl) lysine: an Advanced Glycation end product of the Maillard reaction.
- Glucagon-like peptide-1 (GLP-1) inhibits Advanced Glycation end product (AGE) -induced up-regulation of VCAM-1 mRNA levels in endothelial cells by suppressing …
- Circulating soluble receptor for Advanced Glycation end product identifies patients with bicuspid aortic valve and associated aortopathies
- Increased serum endogenous secretory receptor for Advanced Glycation end-product (esRAGE) levels in type 2 diabetic patients with decreased renal function
- Advanced Glycation end-product cross-linking inhibits biomechanical plasticity and characteristic failure morphology of native tendon
- Effect of Advanced Glycation end product on paraoxonase 2 expression: Its impact on endoplasmic reticulum stress and inflammation in HUVECs
- Morpho-mechanical intestinal remodeling in type 2 diabetic GK rats—is it related to Advanced Glycation end product formation?
- Autophagy protects Advanced Glycation end product -induced apoptosis and expression of MMP-3 and MMP-13 in rat chondrocytes
- Advanced Glycation end product (AGE) : Characterization of the products from the reaction between D‐glucose and serum albumin
- Identification of a novel Advanced Glycation end product derived from lactaldehyde
- Efficacy of adjunctive photodynamic therapy on the clinical periodontal, HbA1c and Advanced Glycation end product levels among mild to moderate chronic …
- Korean red ginseng extract alleviates Advanced Glycation end product -mediated renal injury
- Telmisartan, an angiotensin II type 1 receptor blocker, inhibits Advanced Glycation end-product (AGE) -induced monocyte chemoattractant protein-1 expression in …
- Serum carboxymethyl-lysine, a dominant Advanced Glycation end product , is associated with chronic kidney disease: the Baltimore longitudinal study of aging
- Soluble receptor for Advanced Glycation end product ameliorates chronic intermittent hypoxia induced renal injury, inflammation, and apoptosis via P38/JNK …
- … inhibits inflammation via phospho-P38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB pathways in Advanced Glycation end product -stimulated …
- Effect of age and menopause on serum concentrations of pentosidine, an Advanced Glycation end product
- Attenuating effects of Ganoderma lucidum polysaccharides on myocardial collagen cross-linking relates to Advanced Glycation end product and antioxidant enzymes …
- Targeting the AGE‐RAGE axis improves renal function in the context of a healthy diet low in Advanced Glycation end‐product content
- Imidazolone, a novel Advanced Glycation end product , is present at high levels in kidneys of rats with streptozotocin‐induced diabetes
- The relationship of glycaemic level to Advanced Glycation end-product (AGE) accumulation and retinal pathology in the spontaneous diabetic hamster
- Polymorphism screening of four genes encoding Advanced Glycation end-product putative receptors: association study with nephropathy in type 1 diabetic patients
- Non-invasive skin autofluorescence, blood and urine assays of the Advanced Glycation end product (AGE) pentosidine as an indirect indicator of AGE content …
- Evaluation of autofluorescent property of hemoglobin-Advanced Glycation end product as a long-term glycemic index of diabetes
- Dietary genistein inhibits methylglyoxal-induced Advanced Glycation end product formation in mice fed a high-fat diet
- Advanced Glycation end-product expression is upregulated in the gastrointestinal tract of type 2 diabetic rats
- Advanced Glycation end product Inhibition by Alkaloids from Ocotea paranapiacabensis for the Prevention of Skin Aging
- Curcumin inhibits Advanced Glycation end product ‑induced oxidative stress and inflammatory responses in endothelial cell damage via trapping …
- Regulation of inducible nitric oxide synthase expression in Advanced Glycation end product –stimulated RAW 264.7 cells: the role of heme oxygenase-1 and …
- Immunogenicity of DNA-Advanced Glycation end product fashioned through glyoxal and arginine in the presence of Fe3+: its potential role in prompt recognition of …
- Glucagon-like peptide-1 regulates mitochondrial biogenesis and tau phosphorylation against Advanced Glycation end product -induced neuronal insult: Studies in vivo …
- Inhibitors of Advanced Glycation end product -associated protein cross-linking
- Relation between development of nephropathy and the p22phox C242T and receptor for Advanced Glycation end product G1704T gene polymorphisms in type 2 …
- Arginine side-chain modification that occurs during copper-catalysed azide–alkyne click reactions resembles an Advanced Glycation end product
- Concentrations of pentosidine, an Advanced Glycation end-product, in umbilical cord blood
- Effect on the mechanical properties of type I collagen of intra-molecular lysine-arginine derived Advanced Glycation end-product cross-linking
- Exercise training initiated in late middle age attenuates cardiac fibrosis and Advanced Glycation end-product accumulation in senescent rats
- Effect of diabetes and aminoguanidine therapy on renal Advanced Glycation end-product binding
- Biocatalytic Reversal of Advanced Glycation end product Modification.
- Decreased Soluble Receptor of Advanced Glycation end product Levels Correlated with Inflammation in Silicosis
- Atrial fibrillation coincides with the Advanced Glycation end product Nε-(carboxymethyl) lysine in the atrium
- Skin autofluorescence as a measure of Advanced Glycation end product levels is associated with carotid atherosclerotic plaque burden in an elderly population
- Oral administration of AST-120 (Kremezin) is a promising therapeutic strategy for Advanced Glycation end product (AGE) -related disorders
- Carnosine prevents testicular oxidative stress and Advanced Glycation end product formation in D‐galactose‐induced aged rats
- AntiGlycationeffect of various vegetables: Inhibition of Advanced Glycation end product formation in glucose and human serum albumin reaction system
- Advanced Glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with …
- Pigment epithelium-derived factor (PEDF) ameliorates Advanced Glycation end product (AGE) -induced hepatic insulin resistance in vitro by suppressing Rac-1 …
- Advanced Glycation end products accelerate ischemia/reperfusion injury through receptor of Advancedend product /nitrative thioredoxin inactivation in cardiac …
- … exfoliated deciduous teeth ameliorate diabetic nephropathy in vivo and in vitro by inhibiting Advanced Glycation end product -activated epithelial-mesenchymal …
- Advanced Glycation end product deposits in climatic droplet keratopathy
- Dietary Advanced Glycation end-product consumption leads to mechanical stiffening of murine intervertebral discs
- Advanced Glycation end product 3 (AGE3) suppresses the mineralization of mouse stromal ST2 cells and human mesenchymal stem cells by increasing TGF-β …
- Role of moesin, Src, and ROS in Advanced Glycation end product ‐induced vascular endothelial dysfunction
- Advanced Glycation end product in diabetic rat skeletal muscle in vivo
- Use of skin Advanced Glycation end product levels measured using a simple noninvasive method as a biological marker for the diagnosis of neuropsychiatric diseases
- Effect of Advanced Glycation end product –modified albumin on tissue factor expression by monocytes: role of oxidant stress and protein tyrosine kinase activation
- Psoralea corylifolia L. Seed Extract Attenuates Methylglyoxal-Induced Insulin Resistance by Inhibition of Advanced Glycation end product Formation
- Diabetic kidney disease: a role for Advanced Glycation end-product receptor 1 (AGE-R1)?
- Advanced Glycation end product -induced peroxisome proliferator-activated receptor γ gene expression in the cultured mesangial cells
- Correlation between diabetic retinopathy severity and elevated skin autofluorescence as a marker of Advanced Glycation end-product accumulation in type 2 diabetic …
- Food restriction prevents Advanced Glycation end product accumulation and retards kidney aging in lean rats
- Advanced Glycation end product receptor interactions on microvascular cells occur within caveolin‐rich membrane domains
- Inhibiting receptor for Advanced Glycation end product (AGE) and oxidative stress involved in the protective effect mediated by glucagon-like peptide-1 receptor on …
- Homoisoflavanones from Polygonatum odoratum rhizomes inhibit Advanced Glycation end product formation
- Oxidative stress mediates protein kinase C activation and Advanced Glycation end product formation in a mesangial cell model of diabetes and high protein diet
- Beneficial effect of traditional chinese medicinal formula Danggui-Shaoyao-San on Advanced Glycation end-product-mediated renal injury in streptozotocin …
- Cardiomyocyte mitochondrial respiration is reduced by receptor for Advanced Glycation end-product signaling in a ceramide-dependent manner
- Exosomes derived from mesenchymal stromal cells pretreated with Advanced Glycation end product -bovine serum albumin inhibit calcification of vascular …
- Reaction time in healthy elderly is associated with chronic low-grade inflammation and Advanced Glycation end product
- Carboxymethyl-lysine, an Advanced Glycation end product , and decline of renal function in older community-dwelling adults
- High levels of urinary pentosidine, an Advanced Glycation end product , in children with acute exacerbation of atopic dermatitis: relationship with oxidative stress
- Gly82Ser polymorphism of the receptor for Advanced Glycation end-product (RAGE) potential high risk in patients with colorectal cancer
- Intra-molecular lysine-arginine derived Advanced Glycation end-product cross-linking in Type I collagen: A molecular dynamics simulation study
- S 100 A 9 promotes human lung fibroblast cells activation through receptor for Advanced Glycation end‐product‐mediated extracellular‐regulated kinase 1/2, mitogen …
- Localization of identified Advanced Glycation end‐product structures, Nε=(carboxymethyl) lysine and pentosidine, in age‐related inclusions in human brains
- Astaxanthin and Corni Fructus protect against diabetes-induced oxidative stress, inflammation, and Advanced Glycation end product in livers of streptozotocin-induced …
- Drugs of abuse that mediate Advanced Glycation end product formation: a chemical link to disease pathology
- Beneficial effect of Azadirachta indica on Advanced Glycation end-product in streptozotocin-diabetic rat
- … effects of the hexane extract from Piper auritum leaves in vitro and beneficial activity on oxidative stress and Advanced Glycation end-product-mediated renal injury in …
- Accumulation of the Advanced Glycation end product carboxymethyl lysine in breast cancer is positively associated with estrogen receptor expression and unfavorable …
- Lung level of HMBG1 is elevated in response to Advanced Glycation end product ‐enriched food in vivo
- New therapies for Advanced Glycation end product nephrotoxicity: current challenges
- Circulating soluble receptor for Advanced Glycation end product (sRAGE) and left ventricular hypertrophy in patients with chronic kidney disease (CKD)
- Circulating levels of soluble receptor for Advanced Glycation end product are inversely associated with vascular calcification in patients on haemodialysis independent …
- Bridging Advanced Glycation end product , receptor for Advanced Glycation end product and nitric oxide with hormonal replacement/estrogen therapy in …
- Circulating Advanced Glycation end product levels in rats rapidly increase with acute renal failure
- Clinical implications of Nε‐(carboxymethyl)lysine, Advanced Glycation end product , in children and adolescents with type 1 diabetes
- Autophagy plays a protective role in Advanced Glycation end product -induced apoptosis in cardiomyocytes
- Serum carboxymethyl-lysine, a dominant Advanced Glycation end product , is increased in women with gestational diabetes mellitus
- Advanced Glycation end product free adducts are cleared by dialysis
- Inhibition of Advanced Glycation end product formation by Pu-erh tea ameliorates progression of experimental diabetic nephropathy
- Chemoenzymatic synthesis of heparan sulfate mimetic glycopolymers and their interactions with the receptor for Advanced Glycation end-product
- The Advanced Glycation end-product Nɛ-(carboxymethyl) lysine level is elevated in cerebrospinal fluid of patients with amyotrophic lateral sclerosis
- Skin Advanced Glycation end product accumulation is poorly reflected by glycemic control in type 2 diabetic patients (ZODIAC-9)
- Advanced Glycation end product 3 (AGE3) increases apoptosis and the expression of sclerostin by stimulating TGF-β expression and secretion in osteocyte-like MLO …
- A novel inhibitor of Advanced Glycation end-product formation inhibits mesenteric vascular hypertrophy in experimental diabetes
- Modulation of the cellular expression of circulating Advanced Glycation end-product receptors in type 2 diabetic nephropathy
- Myricetin inhibits Advanced Glycation end product (AGE) -induced migration of retinal pericytes through phosphorylation of ERK1/2, FAK-1, and paxillin in vitro and in …
- Immunodistribution of amyloid beta protein (Aβ) and Advanced Glycation end-product receptors (RAGE) in choroid plexus and ependyma of resuscitated patients
- Differential effects of α-tocopherol and N-acetyl-cysteine on Advanced Glycation end product -induced oxidative damage and neurite degeneration in SH-SY5Y …
- Loratadine alleviates Advanced Glycation end product -induced activation of NLRP3 inflammasome in human chondrocytes
- Expression and significance of high-mobility group protein B1 (HMGB1) and the receptor for Advanced Glycation end-product (RAGE) in knee osteoarthritis
- An Advanced Glycation end product (AGE) -receptor for AGEs (RAGE) axis restores adipogenic potential of senescent preadipocytes through modulation of …
- Altered serum glyceraldehyde-derived Advanced Glycation end product (AGE) and soluble AGE receptor levels indicate carbonyl stress in patients with schizophrenia
- Amadori albumin and Advanced Glycation end-product formation in peritoneal dialysis using icodextrin
- Protective effect of extractive and biotechnological chondroitin in insulin amyloid and Advanced Glycation end product ‐induced toxicity
- Advanced Glycation end-product (AGE) induces apoptosis in human retinal ARPE-19 cells via promoting mitochondrial dysfunction and activating the Fas-FasL …
- Catalpol ameliorates Advanced Glycation end product ‐induced dysfunction of glomerular endothelial cells via regulating nitric oxide synthesis by inducible nitric oxide …
- Elevated serum carboxymethyl-lysine, an Advanced Glycation end product , predicts severe walking disability in older women: The Women’s Health and Aging …
- Advanced Glycation end product Nε‐carboxymethyllysine induces endothelial cell injury: the involvement of SHP‐1‐regulated VEGFR‐2 dephosphorylation
- Renal proximal tubular metabolism of protein-linked pentosidine, an Advanced Glycation end product
- … -Weight Polyphenol Derived from Lychee Fruit, Attenuates Diabetes-Induced Renal Damage through the Advanced Glycation end product –Related Pathway in db/db …
- Vitamin D attenuates human gingival fibroblast inflammatory cytokine production following Advanced Glycation end product interaction with receptors for AGE
- Effects of monascin on anti-inflammation mediated by Nrf2 activation in Advanced Glycation end product -treated THP-1 monocytes and methylglyoxal-treated Wistar …
- Implication of altered redox regulation by antioxidant enzymes in the increased plasma pentosidine, an Advanced Glycation end product , in uremia
- Endoplasmic reticulum stress plays a role in the Advanced Glycation end product -induced inflammatory response in endothelial cells
- Relationship between Advanced Glycation end-product accumulation in the skin and pulmonary function
- Differential effect of estrogen receptor alpha and beta agonists on the receptor for Advanced Glycation end product expression in human microvascular …
- Receptor for Advanced Glycation end product expression in experimental diabetic retinopathy
- Clinical potential of Advanced Glycation end-product inhibitors in diabetes mellitus
- Accelerated Formation of Nϵ-(carboxymethyl) Lysine, an Advanced Glycation end product , by Glyoxal and 3-Deoxyglucosone in Cultured Rat Sensory Neurons
- An emerging role of glucagon-like peptide-1 in preventing advanced–Glycation-end-product-mediated damages in diabetes
- Benazepril, an angiotensin‐converting enzyme inhibitor, alleviates renal injury in spontaneously hypertensive rats by inhibiting Advanced Glycation end‐product …
- Longistatin in tick saliva blocks Advanced Glycation end-product receptor activation
- The inhibitory effect of the catechin structure on Advanced Glycation end product formation in alcoholic media
- Early plasma soluble receptor for Advanced Glycation end‐product levels are associated with bronchiolitis obliterans syndrome
- Detection and determination of glyceraldehyde-derived pyridinium-type Advanced Glycation end product in streptozotocin-induced diabetic rats
- Structure of a synthetic glucose derived Advanced Glycation end product that is immunologically cross-reactive with its naturally occurring counterparts
- Soluble receptor for Advanced Glycation end-product (sRAGE)/pentosidine ratio: a potential risk factor determinant for type 2 diabetic retinopathy
- Diabetes mellitus exacerbates Advanced Glycation end product accumulation in the veins of end-stage renal failure patients
- Dietary Intake of Nε-carboxymethyl-lysine, a Major Advanced Glycation end product , is Not Associated with Increased Risk of Mortality in Japanese Adults in the …
- Circulating soluble receptor for Advanced Glycation end-product levels are decreased in patients with calcific aortic valve stenosis
- N‐Phenacylthiazolium Bromide Inhibits the Advanced Glycation end product (AGE) –AGE Receptor Axis to Modulate Experimental Periodontitis in Rats
- Pigment epithelium-derived factor (PEDF) inhibits Advanced Glycation end product (AGE) -induced C-reactive protein expression in hepatoma cells by …
- Advanced Glycation end product (AGE) inhibitors and their therapeutic implications in diseases.
- Pyridoxamine alleviates mechanical allodynia by suppressing the spinal receptor for Advanced Glycation end product -nuclear factor-κ B/extracellular signal-regulated …
- Accumulation of methylglyoxal increases the Advanced Glycation end-product levels in DRG and contributes to lumbar disk herniation-induced persistent pain
- Protective effect of ISO‑1 against Advanced Glycation end product aggravation of PC12 cell injury induced by Aβ1‑40
- Effect of nitric oxide-cGMP-dependent protein kinase activation on Advanced Glycation end-product–induced proliferation in renal fibroblasts
- Sitagliptin ameliorates Advanced Glycation end-product (AGE) -induced degradation of extracellular matrix in human primary chondrocytes
- Second generation 2-aminoimidazole based Advanced Glycation end product inhibitors and breakers
- Phosphorylation of low density lipoprotein receptor-related protein 6 is involved in receptor for Advanced Glycation end product -mediated β-catenin stabilization in a …
- Effects of Advanced Glycation end-product inhibition and cross-link breakage in diabetic rats
- Increased pentosidine, an Advanced Glycation end‐product, in urine and tissue reflects disease activity in inflammatory bowel diseases
- Inhibition of Advanced Glycation end-product formation by Origanum majorana L. in vitro and in streptozotocin-induced diabetic rats
- Advanced Glycation end product Accumulation is Associated with Lower Cognitive Performance in an Older General Population: The Nagahama Study
- Advanced Glycation end-product levels in subtotally nephrectomized rats: beneficial effects of angiotensin II receptor 1 antagonist losartan
- Neuronal and glial Advanced Glycation end product [Nε-(carboxymethyl)lysine] in Alzheimer’s disease brains
- Advanced Glycation end-product induces fractalkine gene upregulation in normal rat glomeruli
- Amyloid β2-microglobulin is modified with imidazolone, a novel Advanced Glycation end product , in dialysis-related amyloidosis
- Advanced Glycation end product -mediated matrix metallo-proteinase-9 and apoptosis via renin-angiotensin system in type 2 diabetes
- Advanced Glycation end product -induced proliferation in NRK-49F cells is dependent on the JAK2/STAT5 pathway and cyclin D1
- Therapeutic potentials of unicellular green alga Chlorella in Advanced Glycation end product (AGE) -related disorders
- Nifedipine, a calcium channel blocker, inhibits Advanced Glycation end product (AGE) -elicited mesangial cell damage by suppressing AGE receptor (RAGE) …
- Dietary Genistein Reduces Methylglyoxal and Advanced Glycation end product Accumulation in Obese Mice Treated with High-Fat Diet
- Beta carotene protects H9c2 cardiomyocytes from Advanced Glycation end product -induced endoplasmic reticulum stress, apoptosis, and autophagy via the …
- Receptor for Advanced Glycation end-product (RAGE) gene polymorphism 2245G/A is associated with pro-inflammatory, oxidative-Glycationmarkers and sRAGE in …
- Advanced Glycation end product (AGE) -induced hepatic stellate cell activation via autophagy contributes to hepatitis C-related fibrosis
- Pioglitazone alleviates inflammation in diabetic mice fed a high‐fat diet via inhibiting Advanced Glycation end‐product‐induced classical macrophage activation
- Model studies of Advanced Glycation end product modification of heterograft biomaterials: The effects of in vitro glucose, glyoxal, and serum albumin on collagen …
- Advanced Glycation end product (AGE) -AGE receptor (RAGE) system upregulated connexin43 expression in rat cardiomyocytes via PKC and Erk MAPK pathways
- Circulating levels and dietary intake of the Advanced Glycation end-product marker carboxymethyl lysine in chronic kidney disease patients on conservative …
- Antibodies against Advanced Glycation end product Nɛ-(carboxymethyl) lysine in healthy controls and diabetic patients
- Advanced Glycation end‐product‐induced mitogenesis and collagen production are dependent on angiotensin II and connective tissue growth factor in NRK‐49F cells
- Impaired permeability and antimicrobial barriers in type 2 diabetes skin are linked to increased serum levels of Advanced Glycation end‐product
- Age dependent accumulation patterns of Advanced Glycation end product receptor (RAGE) ligands and binding intensities between RAGE and its ligands …
- Nifedipine, a calcium channel blocker, inhibits inflammatory and fibrogenic gene expressions in Advanced Glycation end product (AGE) -exposed fibroblasts via …
- The Advanced Glycation end product -lowering agent ALT-711 is a low-affinity inhibitor of thiamine diphosphokinase
- Amyloid-beta mediates the receptor of Advanced Glycation end product -induced pro-inflammatory response via toll-like receptor 4 signaling pathway in retinal …
- The effects of a maternal Advanced Glycation end product -rich diet on somatic features, reflex ontogeny and metabolic parameters of offspring mice
- Panax notoginseng saponins alleviates Advanced Glycation end product ‑induced apoptosis by upregulating SIRT1 and antioxidant expression levels in HUVECs
- Inhibitory effects of Siegesbeckia orientalis extracts on Advanced Glycation end product formation and key enzymes related to metabolic syndrome
- Association of soluble receptor for Advanced Glycation end-product with increasing central aortic stiffness in hypertensive patients
- Angiopoietin‐1 protects the endothelial cells against Advanced Glycation end product injury by strengthening cell junctions and inhibiting cell apoptosis
- … -6-methoxycyclohexa-2, 5-diene-1, 4-dione, isolated from Averrhoa carambola L.(Oxalidaceae) roots, on Advanced Glycation end-product-mediated renal injury in type …
- Differences in the modulating potential of Advanced Glycation end product (AGE) peptides versus AGE proteins
- DL‑3‑n‑butylphthalide protects endothelial cells against Advanced Glycation end product ‑induced injury by attenuating oxidative stress and inflammation responses
- Alagebrium chloride, a novel Advanced Glycation end-product cross linkage breaker, inhibits neointimal proliferation in a diabetic rat carotid balloon injury …
- Formation of pentosidine cross-linking in myoglobin by glyoxal: detection of fluorescent Advanced Glycation end product
- Circulating soluble receptor for Advanced Glycation end product : Cross-sectional associations with cardiac markers and subclinical vascular disease in older …
- Effect of high Advanced Glycation end product diet on pulmonary inflammatory response and pulmonary function following gastric aspiration
- Rosiglitazone reduces angiotensin II and Advanced Glycation end product -dependent sustained nuclear factor-κB activation in cultured human proximal tubular …
- Isolation and identification of the 3-hydroxy-5-hydroxymethyl-pyridinium compound as a novel Advanced Glycation end product on glyceraldehyde-related Maillard …
- Telmisartan, an angiotensin II type 1 receptor blocker, inhibits Advanced Glycation end-product (AGE) -elicited hepatic insulin resistance via peroxisome proliferator …
- Lysine‐Arginine Advanced Glycation End‐Product Cross‐links and the Effect on Collagen Structure: A Molecular Dynamics Study
- Minodronate, a nitrogen-containing bisphosphonate, inhibits Advanced Glycation end product -induced vascular cell adhesion molecule-1 expression in endothelial …
- Peel extract of water chestnut (Trapa bispinosa Roxb.) inhibits Glycation, degradesα-dicarbonyl compound, and breaks Advanced Glycation end product …
- Advanced Glycation end-product-induced mitogenesis is dependent on Janus kinase 2-induced heat shock protein 70 in normal rat kidney interstitial fibroblast cells
- Effects of Advanced Glycation end product modification on proximal tubule epithelial cell processing of albumin
- Study of an unusual Advanced Glycation end-product (AGE) derived from glyoxal using mass spectrometry
- Increased Advanced Glycation end product and meat consumption is associated with childhood wheeze: analysis of the National Health and Nutrition Examination …
- Irbesartan inhibits Advanced Glycation end product (AGE) -induced up-regulation of vascular cell adhesion molecule-1 (VCAM-1) mRNA levels in glomerular …
- Advanced Glycation end product in familial amyloidotic polyneuropathy (FAP)
- iRAGE as a novel carboxymethylated peptide that prevents Advanced Glycation end product -induced apoptosis and endoplasmic reticulum stress in vascular smooth …
- Coptis chinensis Polysaccharides Inhibit Advanced Glycation end product Formation
- Age-related accumulation of Advanced Glycation end-products-albumin, S100β, and the expressions of Advanced Glycation end product receptor differ in visceral and …
- Inhibitory effect of Arachis hypogaea (Peanut) and its phenolics against methylglyoxal-derived Advanced Glycation end product toxicity
- Novel inhibitory effects of glycyrrhizic acid on the accumulation of Advanced Glycation end product and its receptor expression
- The downregulation of thioredoxin accelerated Neuro2a cell apoptosis induced by Advanced Glycation end product via activating several pathways
- A significant inhibitory effect on Advanced Glycation end product formation by catechin as the major metabolite of lotus seedpod oligomeric procyanidins
- Serum Carboxymethyllysine, an Advanced Glycation end product , and Age-Related Macular Degeneration: The Age, Gene/Environment Susceptibility–Reykjavik …
- The neuroprotective role of rosiglitazone in Advanced Glycation end product treated human neural stem cells is PPARgamma-dependent
- Advanced Glycation end product levels were correlated with inflammation and carotid atherosclerosis in type 2 diabetes patients
- Skin Advanced Glycation end-product accumulation is negatively associated with calcaneal osteo-sono assessment index among non-diabetic adult …
- Kuwanon G protects HT22 cells from Advanced Glycation end product -induced damage
- Soluble receptor for Advanced Glycation end-product levels are related to albuminuria and arterial stiffness in essential hypertension
- Pentosidine, an Advanced Glycation end-product, may reflect clinical and morphological features of hand osteoarthritis
- Advanced Glycation end-product (AGE) -albumin from activated macrophage is critical in human mesenchymal stem cells survival and post-ischemic …
- Characterization of anti-Advanced Glycation end product antibodies to nonenzymatically lysine-derived and arginine-derived glycated products
- The antioxidant 3H-1, 2-dithiole-3-thione potentiates Advanced Glycation end-product-induced oxidative stress in SH-SY5Y cells
- Troxerutin suppresses the inflammatory response in Advanced Glycation end-product-administered chondrocytes and attenuates mouse osteoarthritis development
- Simultaneous determination of the Advanced Glycation end product N ɛ-carboxymethyllysine and its precursor, lysine, in exhaled breath condensate using isotope …
- Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits Advanced Glycation end product …
- Advanced Glycation end-product pentosidine is not a relevant marker of disease activity in patients with rheumatoid arthritis.
- Leptin and connective tissue growth factor in Advanced Glycation end‐product‐induced effects in NRK‐49F cells
- The role of autophagy in Advanced Glycation end product -induced proliferation and migration in rat vascular smooth muscle cells
- Agonism of GPR39 displays protective effects against Advanced Glycation end-product (AGE) -induced degradation of extracellular matrix in human SW1353 cells
- Free Advanced Glycation end product distribution in blood components and the effect of genetic polymorphisms
- Pioglitazone Inhibits Advanced Glycation end product -Induced TNF-E and MMP-13 Expression via the Antagonism of NF-TB Activation in Chondrocytes
- Silybin, a flavonolignan from milk thistle seeds, restrains the early and Advanced Glycation end product modification of albumin
- Methylglyoxal-hydroimidazolones (MG-Hs) instead of Nɛ-(carboxymethyl)-l-lysine (CML) is the major Advanced Glycation end-product during drying process in black …
- Age-dependent expression of Advanced Glycation end product receptor genes in the human heart
- … n-3 polyunsaturated fatty acids revert renal responses induced by a combination of 2 protocols that increase the amounts of Advanced Glycation end product …
- Serum pentosidine, an Advanced Glycation end product , indicates poor outcomes after acute ischemic stroke
- Advanced Glycation end product is implicated in amyloid‐related kidney complications
- Programmed cell death protein 4 deficiency suppresses foam cell formation by activating autophagy in Advanced Glycation end‐product low‐density lipoprotein …
- Imaging receptor for Advanced Glycation end product expression in mouse model of hind limb ischemia
- TRC4149 a novel Advanced Glycation end product breaker improves hemodynamic status in diabetic spontaneously hypertensive rats
- Renoprotective and lipid‐lowering effects of LR compounds, Novel Advanced Glycation end product inhibitors, in streptozotocin‐induced diabetic rats
- Advanced Glycation end-product peptides are associated with impaired renal function, but not with biochemical markers of endothelial dysfunction and inflammation …
- C-Type Natriuretic Peptide Protects the Retinal Pigment Epithelium against Advanced Glycation end product –Induced Barrier Dysfunction
- RETRACTED: Pigment epithelium-derived factor inhibits Advanced Glycation end-product-induced angiogenesis and stimulates apoptosis in retinal endothelial cells
- The Receptor for Advanced Glycation end product (RAGE) Pathway in COVID-19
- Absence of Receptor for Advanced Glycation end product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1 G93A Mouse Model of Amyotrophic …
- … and angiotensin converting enzyme inhibitors: implication of radical scavenging and transition metal chelation in inhibition of Advanced Glycation end product …
- Grape seed procyanidin B2 inhibits Advanced Glycation end product ‐induced endothelial cell apoptosis through regulating GSK3β phosphorylation
- Angelica Acutiloba Root Alleviates Advanced Glycation End‐Product‐Mediated Renal Injury in Streptozotocin‐Diabetic Rats
- Circulating soluble Advanced Glycation end product is inversely associated with the significant risk of developing cancer: evidence from a meta-analysis
- … atherogenesis via inhibiting Advanced Glycation end product -induced receptor for Advancedglycosylation end product expression in apolipoprotein-E …
- Minimum stable structure of the receptor for Advanced Glycation end product possesses multi ligand binding ability
- Carboxymethyl lysine, an Advanced Glycation end product , and incident diabetes: a case–cohort analysis of the ARIC Study
- Advanced Glycation end-product accumulation reduces vitreous permeability
- Pigment epithelium-derived factor (PEDF) blocks Advanced Glycation end product (AGE) -induced angiogenesis in vitro
- Can Advanced Glycation end product inhibitors modulate more than one pathway to enhance renoprotection in diabetes?
- The role of black soybean and purple sweet potato active compound on Advanced Glycation end-product in streptozotocin-induced type 2 diabetes mellitus rat
- Suppression of high-mobility group box-1 and receptor for Advanced Glycation end-product axis by polymyxin B–immobilized fiber hemoperfusion in septic shock …
- Low Advanced Glycation end product diet improves the central obesity, insulin resistance and inflammatory profiles in Iranian patients with metabolic syndrome: a …
- Inhibitory effect of zinc on the Advanced Glycation end product -induced apoptosis of mouse osteoblastic cells
- Inhibitors of Advanced Glycation end product (AGE) Formation and Accumulation
- Inhibitory effect of lotus seedpod oligomeric procyanidins on Advanced Glycation end product formation in a lactose-lysine model system
- Rivaroxaban inhibits oxidative and inflammatory reactions in Advanced Glycation end product -exposed tubular cells by blocking thrombin/protease-activated receptor …
- Blocking the receptor for Advanced Glycation end product activation attenuates autoimmune myocarditis
- Elevated soluble receptor for Advanced Glycation end product levels in patients with acute coronary syndrome and positive cardiac troponin I
- 2 ″, 4 ″-O-diacetylquercitrin, a novel Advanced Glycation end-product formation and aldose reductase inhibitor from Melastoma sanguineum
- Formation of Advanced Glycation end‐product‐modified superoxide dismutase‐1 (SOD1) is one of the mechanisms responsible for inclusions common to familial …
- Lower serum endogenous secretory receptor for Advanced Glycation end product level as a risk factor of metabolic syndrome among Japanese adult men: a 2-year …
- High serum concentrations of pentosidine, an Advanced Glycation end product , are associated with low normal value of ankle-brachial index in apparently healthy …
- Higher serum soluble receptor for Advanced Glycation end product levels and lower prevalence of metabolic syndrome among Japanese adult men: a cross …
- An interactive association of Advanced Glycation end-product receptor gene four common polymorphisms with coronary artery disease in northeastern Han …
- Relationship of a dominant Advanced Glycation end product , serum carboxymethyl-lysine, and abnormal glucose metabolism in adults: the Baltimore Longitudinal …
- The effect of packed red blood cell storage on arachidonic acid and Advanced Glycation end-product formation
- The roles of protein Glycation, glycoxidation, and Advanced Glycation end-product formation in diabetes-induced atherosclerosis
- 2-ammonio-6-(3-oxidopyridinium-1-yl) hexanoate (OP-lysine) is a newly identified Advanced Glycation end product in cataractous and aged human lenses
- Advanced Glycation end product -induced astrocytic differentiation of cultured neurospheres through inhibition of Notch-Hes1 pathway-mediated neurogenesis
- Functional polymorphisms of the receptor for the Advanced Glycation end product promoter gene in inflammatory bowel disease: a case–control study
- The protective effects of bexarotene against Advanced Glycation end-product (AGE) -induced degradation of articular extracellular matrix (ECM)
- Singlet oxygen induced Advanced Glycation end-product photobleaching of in vivo human fingertip autofluorescence
- TRB3 mediates Advanced Glycation end product -induced apoptosis of pancreatic β-cells through the protein kinase C β pathway
- Involvement of caspase-10 in Advanced Glycation end-product-induced apoptosis of bovine retinal pericytes in culture
- Carboxymethyllysine, an Advanced Glycation end-product, promotes the invasion and migration of lung cancer A549 cells
- Advanced–Glycation-end-product-cholesterol-aggregated-protein accelerates the proliferation of mesangial cells mediated by transforming-growth-factor-beta 1 …
- Advanced Glycation end product -modified β2-microglobulin is a component of amyloid fibrils of primary localized cutaneous nodular amyloidosis
- Immunochemical detection of N2-[1-(1-carboxy) ethyl] guanosine, an Advanced Glycation end product formed by the reaction of DNA and reducing sugars or L …
- Pioglitazone attenuates atherosclerosis in diabetic mice by inhibition of receptor for Advanced Glycation end-product (RAGE) signaling
- Advanced Glycation end product concentrations in follicular fluid of women undergoing IVF/ICSI with a GnRH agonist protocol
- Allium sativum aqueous extract inhibitory effect on Advanced Glycation end product
- Receptor for Advanced Glycation end product polymorphisms and type 2 diabetes: the CODAM study
- Caffeoylated phenylpropanoid glycosides from Brandisia hancei inhibit Advanced Glycation end product formation and aldose reductase in vitro and vessel …
- Antiglycative effect of Kaempferia parviflora Wall. Ex. Baker (Zingiberaceae): Prevention of Advanced Glycation end product formation.
- Mass spectrometry to detect the site specificity of AdvancedGlycation/lipoxidation end-product formation on protein: some challenges and solutions
- … medoxomil, a newly developed angiotensin II type 1 receptor antagonist, protects against renal damage in Advanced Glycation end product (AGE) -injected rats.
- Gelatin as a convenient surrogate protein to model the in vitro effects of Advanced Glycation end‐product formation
- Receptor of Advanced Glycation end product (RAGE) expression in the minor salivary glands of patients with Sjo˝ gren’s syndrome: a preliminary study
- Prostaglandin E2 inhibits Advanced Glycation end product -induced adhesion molecule expression, cytokine production, and lymphocyte proliferation in human …
- Reduced systemic Advanced Glycation end products in children receiving peritoneal dialysis with low glucose degradation product content
- Amelioration of experimental autoimmune uveoretinitis by inhibition of glyceraldehyde‐derived Advanced Glycation end‐product formation
- Paradox of circulating Advanced Glycation end product concentrations in patients with congestive heart failure and after heart transplantation
- … and biological activity of 4-aryl-3-benzoyl-5-phenylspiro [pyrrolidine-2.3′-indolin]-2′-one derivatives as novel potent inhibitors of Advanced Glycation end product
- Anti-glycative effect of yogurt: Prevention of Advanced Glycation end product formation
- Up-regulation of the receptor for Advanced Glycation end product (RAGE) in esophageal cancer and down-regulation in lung cancer and their relationship to …
- Nifedipine, a calcium-channel blocker, inhibits Advanced Glycation end-product-induced expression of monocyte chemoattractant protein-1 in human cultured …
- An inhibitor of Advanced Glycation end product formation reducesNϵ-(carboxymethyl) lysine accumulation in glomeruli of diabetic rats
- Association of Advanced Glycation end-product accumulation with overactive bladder in community-dwelling elderly: A cross-sectional Sukagawa study
- Vardenafil, an inhibitor of phosphodiesterase-5, blocks Advanced Glycation end product (AGE) -induced up-regulation of monocyte chemoattractant protein-1 mRNA …
- DW1029M, a novel botanical drug candidate, inhibits Advanced Glycation end-product formation, rat lens aldose reductase activity, and TGF-β1 signaling
- Morphological adaptation of muscle collagen and receptor of Advanced Glycation end product (RAGE) in osteoarthritis patients with 12 weeks of resistance training …
- Identification of (−)-epigallocatechin (EGC) as a methylglyoxal (MGO)-trapping agent and thereby as an inhibitor of Advanced Glycation end product (AGE) …
- A novel pleiotropic effect of atorvastatin on Advanced Glycation end product (AGE) -related disorders
- Advanced Glycation end product accumulation in rho0 cells without a functional respiratory chain
- A novel crosslinked type of Advanced Glycation end-product derived from lactaldehyde
- Role of peroxisome proliferators-activated receptor-gamma in Advanced Glycation end product -mediated functional loss of voltage-gated potassium channel …
- Receptor for Advanced Glycation end product blockade enhances the chemotherapeutic effect of cisplatin in tongue squamous cell carcinoma by reducing autophagy …
- Impact of diet-induced obesity in male mouse reproductive system: The role of Advanced Glycation end product –receptor for Advanced Glycation end product axis
- Receptor for Advanced Glycation end-product rs1800624 polymorphism contributes to increase breast cancer risk: Evidence from a meta-analysis
- Anti-glycative effect of Japanese sake (seishu): prevention of Advanced Glycation end product (AGE) formation
- RACK1 mediates the Advanced Glycation end product ‐induced degradation of HIF‐1α in nucleus pulposus cells via competing with HSP90 for HIF‐1α binding
- … activity are related to components of the metabolic syndrome, but not to circulating concentrations of the Advanced Glycation end-product Nɛ-carboxymethyl-lysine in …
- Effect of rice bran extract on in vitro Advanced Glycation end product formation
- Association analysis between genomic variants within Advanced Glycation end product specific receptor (AGER) gene and risk of breast cancer in Iranian …
- Levels of mature cross-links and Advanced Glycation end product cross-links in human vitreous
- Myocardial infarction coincides with increased expression of NO2X2 and the Advanced Glycation end product Ne-(carboxymethyl) lysine in the microvasculature of the …
- Advanced Glycation end product (AGE) inhibition as a possible pharmacotherapeutic strategy in the treatment of Alzheimer’s disease
- Processing Advanced Glycation end product ‐Modified Albumin by the Renal Proximal Tubule and the Early Pathogenesis of Diabetic Nephropathy
- Reasons to investigate the soluble receptor for Advanced Glycation end-product (sRAGE) pathway in aortic disease
- Effect of nicotine on Advanced Glycation end product -induced immune response in human monocytes
- INVESTIGATION OF CHANGES IN LEVELS OF SERUM ELEMENTS, LIPID PROFILE AND Advanced Glycation end product IN PATIENTS WITH …
- Production of single-chain Fv antibodies specific for GA-Pyridine, an Advanced Glycation end-product (AGE) , with reduced inter-domain motion
- Pioglitazone suppresses Advanced Glycation end product -induced expression of plasminogen activator inhibitor-1 in vascular smooth muscle cells
- The protection of 4, 4′-diphenylmethane-bis (methyl) carbamate from Cortex Mori on Advanced Glycation end product -induced endothelial dysfunction: Via inhibiting …
- Advanced Glycation end (AGE) product modification of laminin downregulates Kir4. 1 in retinal Müller cells
- Advanced Glycation end product Inhibitor Pyridoxamine Attenuates IVD Degeneration in Type 2 Diabetic Rats
- Therapeutic effects of antigen affinity-purified polyclonal anti-receptor of Advanced Glycation end-product (RAGE) antibodies on cholestasis-induced liver injury in rats
- Hypoxia‐induced increases in glucose uptake do not cause oxidative injury or Advanced Glycation end‐product (AGE) formation in vascular endothelial cells
- SOCS3 overexpression inhibits Advanced Glycation end product -induced EMT in proximal tubule epithelial cells
- Protective effects of physiological testosterone on Advanced Glycation end product ‑induced injury in human endothelial cells
- Expression of Advanced Glycation end‐product receptors in the cochlea
- Inhibition of Advanced Glycation end-product formation by lutein from Tagetes erecta
- Role of urotensin II in Advanced Glycation end product -induced extracellular matrix synthesis in rat proximal tubular epithelial cells
- Reduction of lipid peroxidation products and Advanced Glycation end‐product precursors by cyanobacterial aldo‐keto reductase AKR3G1—a founding member of the …
- Preventive effects of Rosa rugosa root extract on Advanced Glycation end product -induced endothelial dysfunction
- SUN-LB131 Association of Receptor for Advanced Glycation end product (RAGE) Gene Polymorphisms & Serum Levels of Soluble RAGE (sRAGE) With Metabolic …
- Nε-(Carboxymethyl)Lysine, a Major Advanced Glycation end product in Exhaled Breath Condensate as a Biomarker of Small Airway Involvement in Asthma
- The potential role of Advanced Glycation end product and iNOS in chronic renal failure-related testicular dysfunction
- Pentosidine, Advanced Glycation end product , in acute ischaemic stroke patients with and without atrial rhythm disturbances
- Advanced Glycation end-product-inhibited cell proliferation and protein expression of β-catenin and cyclin D1 are dependent on glycogen synthase kinase 3β in LLC …
- Domain I-IV of β2-glycoprotein I inhibits Advanced Glycation end product -induced angiogenesis by down-regulating vascular endothelial growth factor 2 …
- Association of serum carboxymethyl-lysine, a dominant Advanced Glycation end product , with anemia in adults: the Baltimore Longitudinal Study of Aging
- Isolation and identification of 5-methyl-imidazolin-4-one derivative as glyceraldehyde-derived Advanced Glycation end product
- Interferon-γ mediates the protective effects of soluble receptor for Advanced Glycation end-product in myocardial ischemia/reperfusion
- The Advanced Glycation end product Nϵ‐carboxymethyllysine and its precursor glyoxal increase serotonin release from Caco‐2 cells
- Reduction of Advanced Glycation end‐product (AGE) levels in nervous tissue proteins of diabetic Lewis rats following islet transplants is related to different durations of …
- … analysis of contractility in the ileum in response to flow and ramp distension in streptozotocin-induced diabetic rats—Association with Advanced Glycation end product …
- Phenolic Compounds from the Leaves of Homonoia riparia and their Inhibitory Effects on Advanced Glycation end product Formation
- Abundance, localization, and functional correlates of the Advanced Glycation end‐product carboxymethyl lysine in human myocardium
- … evaluation of novel 2, 3, 5-triaryl-4H, 2, 3, 3a, 5, 6, 6a-hexahydropyrrolo [3, 4-d] isoxazole-4, 6-diones for Advanced Glycation end product formation inhibitory activity
- Possible involvement of altered RGD sequence in reduced adhesive and spreading activities of Advanced Glycation end product -modified fibronectin to vascular …
- Nitroxidized-Albumin Advanced Glycation end product and Rheumatoid Arthritis
- Detection and determination of glyceraldehyde-derived Advanced Glycation end product
- Impact of chronic renal failure and peritoneal dialysis fluids on Advanced Glycation end product and iNOS levels in penile tissue: an experimental study
- The marine natural product Scalarin inhibits the receptor for Advanced Glycation end products (RAGE) and autophagy in the PANC-1 and MIA PaCa-2 pancreatic …
- Combination of medicinal herbs KIOM-79 reduces Advanced Glycation end product accumulation and the expression of inflammatory factors in the aorta of …
- Immunohistochemistry of Advanced Glycation end product N ε-(carboxymethyl) lysine in coronary arteries in relation to cardiac fibrosis and serum N-terminal …
- The Development of Maillard Reaction, and Advanced Glycation end product (AGE) -Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for …
- Pigment epithelium-derived factor (PEDF) inhibits diabetes-or Advanced Glycation end product (AGE) -induced platelet CD40 ligand overexpression in rats
- Role of peroxisome proliferators-activated receptor-gamma in Advanced Glycation end product -mediated functional loss of voltage-gated potassium channel in rat …
- GW28-e0833 Inhibition of myocardial ischemia/reperfusion apoptosis by soluble receptor for Advanced Glycation end-product (sRAGE) via interferon-induced …
- Advanced Glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study
- N ε-Carboxymethyllysine (CML), a Maillard reaction product, stimulates serotonin release and activates the receptor for Advanced Glycation end products (RAGE) in …
- Identification of N2-(1-carboxymethyl) guanine (CMG) as a guanine Advanced Glycation end product
- Endogenous secretory receptor for Advanced Glycation end product levels are inversely associated with HbA1c in type 2 diabetic patients
- On resin synthesis and cross-linking of collagen peptides containing the Advanced Glycation end-product pyrraline via Maillard condensation
- … -6-(2-formyl-5-hydroxymethyl-pyrrol-l-yl)-hexanoic acid (‘pyrraline’) as an early-stage product or Advanced Glycation end product in non-enzymic protein Glycation
- The Association Between Anemia and Skin Autofluorescence, a Marker for Advanced Glycation end product Accumulation
- Comment on: Thallas-Bonke et al.(2008) Inhibition of NADPH Oxidase Prevents Advanced Glycation end product –Mediated Damage in Diabetic Nephropathy …
- Can soluble receptor for Advanced Glycation end-product (sRAGE) levels in blood be used as a predictor of cardiovascular diseases?
- Blue native/SDS‐PAGE combined with iTRAQ analysis reveals Advanced Glycation end‐product‐induced changes of synaptosome proteins in C57 BL/6 mice
- Potential therapeutic implication of nifedipine, a dihydropyridine-based calcium antagonist, in Advanced Glycation end product (AGE) -related disorders
- Renoprotective effects of azelnidipine, a dihydropyridine-based calcium antagonist in Advanced Glycation end product (AGE) -injected rats.
- Protective effect of Gymnema sylvestre L. against Advanced Glycation end‑product, sorbitol accumulation and aldose reductase activity in Homoeopathic Formulation
- Expression of receptor for Advanced Glycation end product mRNA by human peritoneal mesothelial cells
- Inhibitors of Advanced Glycation end products from coffee bean roasting by-product
- Genistein attenuates Advanced Glycation end product -induced expression of fibronectin and connective tissue growth factor
- Blockade by nifedipine of Advanced Glycation end product -induced CD40-CD40 ligand interaction in endothelial cells.
- Prevention of proliferative diabetic retinopathy and cataract in SDT rats with aminoguanidine, an anti-Advanced Glycation end product agent
- Ginsenoside derivatives inhibit Advanced Glycation end-product formation and glucose–fructose mediated protein Glycationin vitro via a specific structure–activity …
- Preparation of monoclonal antibodies against different epitopes on extracellular domain of human receptor for Advanced Glycation end product .
- Cold Storage Increases Albumin and AdvancedGlycation–end product -Albumin Levels in Kidney Transplants: A Possible Cause for Exacerbated Renal …
- Inhibitory effect of caffeic acid on Advanced Glycation end product ‐induced renal fibrosis in vitro: A potential therapeutic target
- Prostaglandin E2 inhibits Advanced Glycation end product -induced adhesion molecule expression on monocytes, cytokine production, and lymphocyte proliferation …
- Inhibitory effect of receptor for Advanced Glycation end product ‑specific small interfering RNAs on the development of hepatic fibrosis in primary rat hepatic …
- Anti-Advanced Glycation end-product and free radical scavenging activity of plants from the yucatecan flora
- Combination therapy with nateglinide and telmisartan ameliorates insulin resistance in Zucker fatty rats by suppressing Advanced Glycation end product receptor axis
- … product peritoneal dialysis regimen is associated with lower plasma EN‐RAGE and HMGB‐1 proinflammatory ligands of receptor for Advanced Glycation end products
- Advanced Glycation end product LEVELS IN EYE LENSES, AORTA, AND TAIL TENDON IN TRANSPLANTED DIABETIC INBRED LEWIS RATS1
- Increased Advanced Glycation end product specific fluorescence in repeatedly heated used cooking oil
- Telmisartan blocks Advanced Glycation end product (AGE) -induced plasminogen activator inhibitor-1 (PAI-1) gene expression in endothelial cells via activation of …
- Chlorogenic acid isomers from Sorbus commixta of ulleung island origin and their inhibitory effects against Advanced Glycation end product (AGE) formation and …
- Correlation of endogenous secretory receptor for Advanced Glycation end product (esRAGE) with metabolic health related biomarkers of skeletal muscle
- Deterioration of Glutaraldehyde Crosslinked Heterograft Biomaterials due to Advanced Glycation end product Formation and Serum Albumin Infiltration
- Analysis of differentially expressed Advanced Glycation end product -modified proteins in diabetic rat kidney
- Advanced Glycation end product inhibitory effect of quercetin-3-O-rutinoside, isolated from Teucrium polium
- Role of myosin light chain and myosin light chain kinase in Advanced Glycation end product –induced endothelial hyperpermeability in vitro and in vivo
- Advanced Glycation end product (AGE) ‐immunoreactive materials in chronic prurigo patients receiving a long‐standing haemodialysis
- Prokaryotic expression of receptor for Advanced Glycation end product and screening of its interaction proteins [J]
- Abstract B26: A novel dietary Advanced Glycation end product (AGE) model to assess impact on tumor progression
- Effect of γ-Glutamyl Cysteine Derivatives from Garlic on Advanced Glycation End-Product (AGE) Formation during Food Processing
- Effects of arginine supplementation on exogenous Advanced Glycation end product -induced renal inflammatory mediator expression in rats
- Interrelationship of elevated serum Advanced Glycation End-product levels and malnutrition (Subjective Global Assessment) scores with the severity of retinopathy in …
- The receptor for Advanced Glycation end product (RAGE) binding to HMGB1 and subsequent NADPH oxidase activation mediates ectopic intestinal inflammation in …
- Expression of receptors of Advanced Glycation end product (RAGE) and types I, III and IV collagen in the vastus lateralis muscle of men in early stages of knee …
- Effect of Process Conditions on Advanced Glycation end product Formation in BSA-Glucose System [J]
- Advanced Glycation end-product cross-link breakers: A novel therapeutic pathway for cardiovascular disease
- A soluble receptor for Advanced Glycation end product levels in patients with systemic lupus erythematosus
- 2215-PUB: Serum Levels of the Advanced Glycation end product (AGE) Pentosidine Do Not Correlate with the Extent of Coronary Artery Disease Assessed by …
- THE THERAPEUTIC POTENTIAL OF NIGELLA SATIVA IN THE INHIBITION OF Advanced Glycation end product (AGE) FORMATION: A SYSTEMATIC …
- Anti-skin-aging Effect of Mori Folium through decreased Advanced Glycation end product (AGEs)
- Inhibition of Advanced Glycation end product formation by burdock root extract
- Diabetic nephropathy and low molecular weight Advanced Glycation end-product in urine
- Autophagy plays a protective role in Advanced Glycation end product -induced apoptosis of vascular endothelial cells [J]
- 135: Interruption of the Receptor for Advanced Glycation end product pathway attenuates pulmonary reperfusion injury
- … to” Methylglyoxal-hydroimidazolones (MG-Hs) instead of Nɛ-(carboxymethyl)-l-lysine (CML) is the major Advanced Glycation end-product during drying process in …
- EFFECTS OF ONE YEAR EXERCISE TRAINING WITH A DRUG TO BREAK Advanced Glycation END-PRODUCT CROSS-LINKS ON CARDIAC FUNCTION IN …
- Assessment of Serum Advanced Glycation End-Product Level and Its Effect on Periodontal Health Status in Type 2 Diabetic Patients with Chronic Periodontitis.
- Advanced Glycation end product (AGE) -Mediated Reactive Oxygen Species Production in Cultured Endothelial Cells is Dependent on NADPH Oxidase Activation.
- OxiSelect™ Advanced Glycation end product (AGE) ELISA Kit
- Effect of Advanced Glycation end product on Cellular Proliferation and Expression of Plasminogen Activator Inhibitor-1 in Rat Vascular Smooth Muscle Cell
- Pentosidine and soluble receptor for Advanced Glycation end-product (RAGE) are important prognostic factors independent of renal function in heart failure
- Garlic (Allium sativum) Modulates the Expression of the Receptor for Advanced Glycation end product (RAGE) Isoforms in Renal Tissues of Streptozotocin‐Induced …
- Transient cytosolic free calcium changes in cultured neonatal rat cardiac myocytes in response to Advanced Glycation end-product treatment
- OxiSelect™ Advanced Glycation end product (AGE) Competitive ELISA Kit
- Nervous System Pathophysiology: Accumulation of methylglyoxal increases the Advanced Glycation end-product levels in DRG and contributes to lumbar disk …
- OR-02 SAXAGLIPTIN PREVENTS INCREASED CORONARY ARTERIAL STIFFNESS AND Advanced Glycation end product EXPRESSION IN A …
- Changes of high mobility protein B1 and soluble Advanced Glycation end product receptor in heart failure
- Significantly High Level of Soluble Receptor for Advanced Glycation end product (sRAGE) in Serum: A Predictor of Acute Coronary Syndrome
- GW28-e0060 Changes of high mobility protein B1 and soluble Advanced Glycation end product receptor in elderly patients with congestive heart failure at high altitude
- OxiSelect™ Advanced Glycation end product (AGE) Competitive ELISA Kit, Trial Size
- Assessment of serum ɛN-carboxymethyllysine and soluble receptor of Advanced Glycation end product levels among type 2 diabetes mellitus patients with …
- Ellisras Longitudinal Study 2017: elevated serum levels of carboxymethyl-lysine, an Advanced Glycation end-product, are associated with higher odds of developing …
- An Advanced Glycation end product (AGE) -receptor for AGEs (RAGE) axis restores adipogenic potential of senescent preadipocytes through modulation of p53 protein …
- Antioxidant and anti-AGEs (Advanced Glycation end-product) activities of ethanolic extract of Ficus carica Linn from Indonesia
- Peel extract of water chestnut (Trapa bispinosa Roxb.) inhibits Glycation, degradesα-dicarbonyl compound, and breaks Advanced Glycation end product crosslinks
- Altered serum glyceraldehyde-derived Advanced Glycation end product (AGE) and
- High Serum Level of Pentosidine, an Advanced Glycation end product (AGE) , is a Risk Factor of Patients with Heart Failure
- Non-invasive skin autofluorescence, blood and urine assays of the Advanced Glycation end product (AGE) pentosidine as an indirect indicator of AGE content in …
- Neuroprotective effects of the Advanced Glycation end-product inhibitors LR90 and pyridoxamine in experimental diabetes.
- Advanced Glycation end product inhibitory assay-‘Achyranthes Aspera leaf’
- Advanced Glycation end product and Glycosaminoglycans Levels in Patients with Diabetic Ketoacidosis
- Leptin and connective tissue growyh factor in Advanced Glycation end-product efects in NRK-49F cells.
- … Structural, hemodynamic and clinical improvements among patients with Advancedheart failure treated with Alagebrium (a novel oral Advanced Glycation end-product …
- Effects of dietary AGE (Advanced Glycation end product ) on ovarian microenvironment and oocyte quality
- Biochemical and biophysical characterization of hemoglobin-Advanced Glycation end product and its relevance to diabetes mellitus
- Expression of Advanced Glycation end product (AGE) receptors in corneal endothelial cells
- The Effect of Advanced Glycation end product Inhibition on the Development of Diabetic Encephalopathy in Rats
- AB0291 Association between Pentosidine, an Advanced Glycation End-Product, and Disease Activity in Patients with Untreated Rheumatoid Arthritis. A Preliminary …
- Pentosidine, an Advanced Glycation end product , Is a Negative Predictor of Cortical Bone Geometric Endpoints in Children
- Correlation between receptor for Advanced Glycation end product gene polymorphism and left ventricular hypertrophy
- Promoting effect of receptor for Advanced Glycation end product in periodontitis
- Impact of interaction of Advanced Glycation end product and its receptor on podocytes apoptosis
- Advanced Glycation end product precursors in diabetes: a crucial link between oxidative stress and inflammation?
- Effects of Saengjihwangeum-ja Extracts on the Expression of Inflammatory Response in Human Monocyte Cells Induced by Advanced Glycation end product
- The effect of an insulin releasing agent, BTS 67 582, on Advanced Glycation end product formation in vitro
- Advanced Glycation end product and its Receptor RAGE promote the in-vitro wound healing of HCE corneal epithelial cells
- The Role of Soluble Subtype of the Receptor for Advanced Glycation end product (sRAGE) in Rheumatoid Arthrirtis Disease Activity and Treatment Follow-up
- Relationship Between Soluble Receptor of Advanced Glycation end product and Carotid Atherosclerosis in Patients Under Hemodialysis
- Analysis of the expression of soluble receptor for Advanced Glycation end product and its influencing factors in patients with acute cerebral infarction
- Effect of stimulation to alveolar macrophage by SiO_2 on Advanced Glycation end product receptor and ligand
- The differential effects of fructose and glucose on Advanced Glycation end-product formation and cellular damage in vitro
- Diet-induced obesity may initiate Advanced Glycation end-product-mediated inflammation in articular cartilage
- Association of diabetic retinopathy severity with lens fluorescence ratio reflecting Advanced Glycation end product level
- Advanced Glycation end product and Amadori Product Are Increased and Related to Apoptosis in the Human Diabetic Retina.
- Soluble Receptor For Advanced Glycation end products Are Decreased But Not The Levels Of Advanced Glycation end product Ne-(Carboxymethyl) Lysine In …
- Corni Fructus Inhibits Wrinkle Formation by Reduced Advanced Glycation end product (AGEs)
- Pre-Existing Emphysema Affects Soluble Receptor for Advanced Glycation End-Product Levels in Acute Respiratory Distress Syndrome
- Key functional domains of human cardiac troponin-C are susceptible to Advanced Glycation end-product formation in vitro
- Receptor for Advanced Glycation end product (RAGE) mediates retinal ganglion cell loss in experimental glaucoma
- The effect of oral metformin on vitreous Advanced Glycation end-product content in patients with proliferative diabetic retinopathy
- The Effects of Different Diets (High Fat and High Fructose Diet) on the Development of Insulin Resistance and Tissue Advanced Glycation end product Levels in Rats
- Altered Cell-surface Receptor Levels Result from Fructose Advanced Glycation end product -Induced Inflammation
- Evaluation of receptor for Advanced Glycation end product /high-mobility group box 1 (RAGE/HMGB1) expression status and its prognostic value in breast cancer
- Screening breaker of advanced–Glycationend-product cross-links by enzyme-linked immunosorbent assay method in vitro
- Dialysis-related amyloidosis: role of Advanced Glycation end product -β-microglobulin in joint inflammation
- Effects of pro-inflammatory mediators on Advanced Glycation end product receptors in type-b synovial cells
- Expression and Clinical Meaning of Plasma Soluble Receptor of Advanced Glycation end product in Patients With Gestational Hypertension Heart Disease
- The Role of Glutathione Maintenance in Protection against Advanced Glycation end product Induced Neurite Degeneration in SH‐SY5Y Cells
- The effects of Buyang Huanwu decoction on Advanced Glycation end product receptor of hippocampus in Alzheimer’s disease mice
- Serum levels of soluble receptor for Advanced Glycation end product in type 2 diabetic patients: possible association with urinary albumin excretion
- The Advanced Glycation end-product inhibitor pyridoxamine traps intermediates formed during lipid peroxidation reactions in vitro and in vivo: Mechanism of action of …
- Effects of Advanced Glycation End-Product Inhibition and Protein Cross-Link Breaking in Diabetic Rats
- Correlation between p. 82G> S polymorphisms of receptor for Advanced Glycation end-product gene and susceptibility to inflammatory bowel diseases
- … and 3H-1, 2-Dithiole-3-Thione in Maintaining Glutathione Status and Protection Against Advanced Glycation end product Induced Neurite Degeneration in SH-SY5Y …
- Advanced Glycation end-product-induced mitogenesis and collagen production are dependent on angiotensin II and connective tissue growth factor in NRK-49F cells.
- Rhinacanthins-rich extract: A potent superoxide scavenger and Advanced Glycation end-product formation inhibitor
- Up-regulation of Receptors for Advanced Glycation end product in the Spinal Cord after Peripheral Nerve Injury
- INHIBITION OF Advanced Glycation END-PRODUCT FORMATION ON EYE LENS PROTEINS BY SALVIA OFFICINALIS EXTRACT
- Trichostatin A abrogates Advanced Glycation end-product-induced retinal pigment epithelium dysfunction in an in vivo model of diabetic eye disease
- N-(carboxymethyl) valine adduct in hemoglobin: A biomarker of Advanced Glycation end product formation and oxidative stress.
- Association of Soluble Receptor for Advanced Glycation end product (sRAGE) with increasing central aortic stiffness in hypertensive patients
- The expression of receptor for Advanced Glycation end product in gingival tissues of type 2 diabetic patients with periodontitis
- Can Different Diets (High Fat and High Fructose Diet) Affect Insulin Resistance, Tissue Advanced Glycation end product Levels in Rats’ Pancreas
- Advanced Glycation end product associated skin autofluorescence and serum corboxymethyl lysine levels in acromegaly
- The Glp-1 Analogue Liraglutide Inhibits the Advanced Glycation End-Product Cml and Nox2 in the Diabetic Heart and Brain
- Dynamics of Circulating Ligands and Soluble Receptor for Advanced Glycation End-Product in Liver Transplantation: 1746
- Response to Comment on: Thallas-Bonke et al.(2008) Inhibition of NADPH Oxidase Prevents Advanced Glycation end product –Mediated Damage in Diabetic …
- Biophysical Characterization of the Interaction between the Receptor for Advanced Glycation end product and High Mobility Group Box 1
- Enhanced Advanced Glycation end product Receptors are Associated With Plaque Neovascularization and Inflammation in Peripheral Atheroma From Patients With …
- Modulation of nicotine and Advanced Glycation end product (AGE) mediated effects by the antioxidant glutathione (G) in fibroblasts
- Effect of Advanced Glycation end product receptor signal transduction on MCP-1 expression of podocyte induced by carboxymethyllysine
- Change and clinical significance of high mobility group protein B1 and its Advanced Glycation end product receptor in patients with systemic lupus erythematosus
- Nucleophilic Compounds Block Advanced Glycation end product (AGE) Formation From Ascorbic Acid in the hSVCT2-enA Transgenic Mouse Model of Lenticular …
- Renal Fibrosis and Glomerulosclerosis in a New Mouse Model of Diabetic Nephropathy and its Regression by BMP-7 and Advanced Glycation End-Product …
- The Role of Brown Adipose Tissue (BAT) Activity inMice Devoid of Receptor for Advanced Glycation end product (RAGE)
- Advanced Glycation End-Product Inhibition With Alagebrium Slows Age-Related Large Vessel Arterial Stiffening in Healthy Elderly Humans
- A role for angiotensin-(1-7) to attenuate Advanced Glycation end product -induced myofibroblast transition in the NRK-52E renal proximal tubule cell line
- Accumulation of argpyrimidine, a methylglyoxal-derived Advanced Glycation end product , increases apoptosis of lens epithelial cells both in vitro and in vivo
- -374 T/A POLYMORPHISM IN THE RECEPTOR OF Advanced Glycation end product (AGER) GENE IS ASSOCIATED WITH ONSET OF DIABETES …
- Advanced Glycation end product (AGE) , soluble receptor for AGE (sRAGE) and inflammation in smokers and mild/moderate chronic obstructive pulmonary disease …
- Effects of grape seed proanthocyanidin extracts on Advanced Glycation end product receptor and connective tissue growth factor in the myocardium of diabetic rats
- Advanced Glycation end-product-induced mitogenesis is dependent on Janus kinase 2-induced heat shock protein 70 in normal rat kidney interstitial fibroblast cells.
- An Advanced Glycation end product (AGE) -Rich Diet Promotes Nε-Carboxymethyl-lysine Accumulation in the Cardiac Tissue and Tendons of Rats
- 2-Ammonio-6-(3-oxidopyridinium-1-yl) hexanoate (OP-lysine) is a newly identified Advanced Glycation end product in cataractous and aged human lenses. Vol. 279 …
- Liraglutide alleviates arteriosclerotic lesions and inhibits receptor for Advanced Glycation end-product expression in diabetic ApoE-/-mice
- Vaccination Using Advanced Glycation end product of Low-Density Lipoprotein Pulsed Dendritic Cells Reduces Atherosclerosis in Diabetic Apoe-/- Mice
- Functional and immunochemical characterization of Advanced Glycation end-product (AGE) -modified low-density lipoproteins (AGE-LDL).
- Treatment With Nitric Oxide (NO) Donors or Pioglitazone Improves CD34+ Cell Dynamics on Advanced Glycation end product (AGE) Modified Basement Membrane
- Circulating Levels and Dietary Intake of the Advanced Glycation End-product Marker Carboxymethyl Lysine in Chronic Kidney Disease Patients on …
- Advanced Glycation end-product-inhibited cell proliferation and protein expression of beta-catenin and cyclin D1 are dependent on glycogen synthase kinase 3 beta in …
- Design, Synthesis and Biological Evaluation of Novel Receptor for Advanced Glycation End-product (RAGE) Inhibitor
- Advanced Glycation end product Modification of Laminin Alters Kir4. 1 Expression in Retinal Glia Cells
- Expression of Receptor for Advanced Glycation end product mRNA and Protein in Cultured Hepatic Stellate Cells Inhibited by Specific Small Interfering RNA
- GW24-e1023 Advanced Glycation end product Modified Low Density Lipoprotein Activates Mast Cells via Toll-Like 4 Receptor Pathway
- Pioglitazone reduces expression of Advanced Glycation end product receptor mRNA in renal cortex of streptozotocin-induced diabetic rats
- The anti-ALS drug riluzole attenuates MCP-1 by high glucose, Advanced Glycation end product (AGE) or TNF-α in cultured human retinal pericytes
- Effect of glycaemic control on the diurnal blood pressure variation and endogenous secretory receptor for Advanced Glycation end product (esRAGE) levels in type 1 …
- Effect of mitogen-activated protein kinase kinase 6-p38 alpha signal pathway on receptor for Advanced Glycation end-product expression in alveolar epithelial cells …
- Development of New Antibody Based Theranostic Agents Targeting the Receptor for Advanced Glycation End-Product (Rage)
- Proteomic Analysis of Advanced Glycation End-Product (AGE) Modified Proteins in High Glucose-Exposed Retinal Müller Glia: Evidence for Age-Mediated Cell …
- Fundus Autofluorescence in a Rabbit Model of Age-Related Macular Degeneration Induced by Advanced Glycation end product Microspheres as Imitation Lipofuscin
- FAILURE OF PANCREAS TRANSPLANTATION TO PREVENT DEPOSITION OF AN Advanced Glycation END-PRODUCT IN TRANSPLANTED KIDNEYS …
- An Advanced Glycation end product (AGE) -receptor for AGEs (RAGE) axis restores adipogenic potential of senescent preadipocytes through modulation of p53 protein …
- … Candido R, Jandeleit-Dahm KA, Thomas MC, Burns WC, Deemer EK, Thorpe SR, Cooper ME, Allen TJ: Advanced Glycation end product intervention reduce diabetes …
- … BY EPLERENONE: RELATIONSHIP BETWEEN MINERALOCORTICOID RECEPTOR, Advanced Glycation end product RECEPTOR AND CAVEOLIN-1 IN …
- Nᵋ-Carboxymethyllysine (CML), a Maillard reaction product, stimulates serotonin release and activates the receptor for Advanced Glycation end products (RAGE) in …
- L-Arginine inhibits in vitro nonenzymatic Glycationand Advancedglycosylated end product formation of human serum albumin
- Advanced Glycation end-products: a review
- Advanced Glycation end products : sparking the development of diabetic vascular injury
- Advanced Glycation end products and the kidney
- Advanced Glycation end-products and atherosclerosis
- Advanced Glycation end products : a Nephrologist’s perspective
- Advanced Glycation end-products and the progress of diabetic vascular complications
- Role of Advanced Glycation end products in diabetic nephropathy
- Effect of collagen turnover on the accumulation of Advanced Glycation end products
- Recent progress in Advanced Glycation end products and diabetic complications
- Advanced Glycation end products in diabetic corneas
- Angiogenesis induced by Advanced Glycation end products and its prevention by cerivastatin
- The role of Advanced Glycation end products in the development of atherosclerosis
- Advanced Glycation end products and the progressive course of renal disease
- Inhibition of protein Glycationand Advanced Glycation end products by ascorbic acid and other vitamins and nutrients
- Advanced Glycation end products in Alzheimer’s disease and other neurodegenerative diseases
- Advanced Glycation end-products and Advancedoxidation protein products in patients with diabetes mellitus
- Advanced Glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes
- Advanced Glycation end products and diabetic complications
- Advanced Glycation end products contribute to amyloidosis in Alzheimer disease
- The biology of the receptor for Advanced Glycation end products and its ligands
- Advanced Glycation end products increase retinal vascular endothelial growth factor expression.
- Advanced Glycation end products and endothelial dysfunction in type 2 diabetes
- Understanding RAGE, the receptor for Advanced Glycation end products
- Advanced Glycation end products , oxidant stress and vascular lesions
- Implication of an increased oxidative stress in the formation of Advanced Glycation end products in patients with end-stage renal failure
- Survey of the distribution of a newly characterized receptor for Advanced Glycation end products in tissues
- Renal catabolism of Advanced Glycation end products : the fate of pentosidine
- Advanced Glycation end products and mortality in hemodialysis patients
- Advanced Glycation end products and diabetic complications: a general overview
- Glucose, Advanced Glycation end products , and diabetes complications: what is new and what works
- Randomized trial of an inhibitor of formation of Advanced Glycation end products in diabetic nephropathy
- Enhanced cellular oxidant stress by the interaction of Advanced Glycation end products with their receptors/binding proteins
- Advanced Glycation end products and nutrition
- Determination of Advanced Glycation end products in serum by fluorescence spectroscopy and competitive ELISA
- Receptor for advanced–Glycationend products
- Regulation of vascular endothelial growth factor expression by Advanced Glycation end products
- Differential accumulation of Advanced Glycation end products in the course of diabetic retinopathy
- Advanced Glycation end products and bone loss during aging
- Advanced Glycation end products and diabetic nephropathy
- Role of Advanced Glycation end products and their receptors in development of diabetic neuropathy
- Breakers of Advanced Glycation end products restore large artery properties in experimental diabetes
- A role for Advanced Glycation end products in diminished bone healing in type 1 diabetes
- Advanced Glycation end products up-regulate gene expression found in diabetic glomerular disease
- Advanced Glycation end products (AGEs)and diabetic vascular complications
- Modification of low density lipoprotein by Advanced Glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency
- Restriction of dietary glycotoxins reduces excessive Advanced Glycation end products in renal failure patients
- Advanced Glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for Advanced Glycation end products (RAGE)
- Advanced Glycation end products , their receptors and diabetic angiopathy
- Advanced Glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation
- Association between serum levels of soluble receptor for Advanced Glycation end products and circulating Advanced Glycation end products in type 2 diabetes
- In vitro kinetic studies of formation of antigenic Advanced Glycation end products (AGEs) : novel inhibition of post-Amadori Glycationpathways
- Importance of Advanced Glycation end products in diabetes-associated cardiovascular and renal disease
- The relationship between accumulation of Advanced Glycation end products and expression of vascular endothelial growth factor in human diabetic retinas
- Cellular receptors for Advanced Glycation end products . Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions.
- A breaker of Advanced Glycation end products attenuates diabetes-induced myocardial structural changes
- Vascular hypertrophy in experimental diabetes. Role of Advanced Glycation end products .
- Toxic Advanced Glycation end products (TAGE) theory in Alzheimer’s disease
- Accumulation of Advanced Glycation end products as a molecular mechanism for aging as a risk factor in osteoarthritis
- Differential effects between amphoterin and Advanced Glycation end products on colon cancer cells
- Advanced Glycation end products induce glomerular sclerosis and albuminuria in normal rats
- Reduction of the accumulation of Advanced Glycation end products by ACE inhibition in experimental diabetic nephropathy
- Characterization of Advanced Glycation end products for biochemical studies: side chain modifications and fluorescence characteristics
- Advanced Glycation end products in nondiabetic patients with coronary artery disease
- Advanced Glycation end products in age-related macular degeneration
- Involvement of Advanced Glycation end-products (AGEs)in Alzheimer’s disease
- Serum levels of Advanced Glycation end products are increased in patients with type 2 diabetes and coronary heart disease.
- RAGE: a novel cellular receptor for Advanced Glycation end products
- Possible participation of Advanced Glycation end products in the pathogenesis of osteoporosis in diabetic patients
- Soluble receptor for Advanced Glycation end products : from disease marker to potential therapeutic target
- Neurotoxicity of Advanced Glycation end-products for cultured cortical neurons
- Glycationin food and metabolic transit of dietary AGEs (Advanced Glycation end-products): studies on the urinary excretion of pyrraline
- Role of Advanced Glycation end products (AGEs)in thrombogenic abnormalities in diabetes
- … association between serum levels of Advanced Glycation end products and the soluble form of receptor for Advanced Glycation end products in nondiabetic subjects
- Advanced Glycation end-products pentosidine and Nϵ-carboxymethyllysine are elevated in serum of patients with osteoporosis
- Increased serum levels of Advanced Glycation end-products and diabetic complications
- Characterization and functional analysis of the promoter of RAGE, the receptor for Advanced Glycation end products
- Regulation of human mononuclear phagocyte migration by cell surface-binding proteins for Advanced Glycation end products .
- Serum levels of Advanced Glycation end products are associated with left ventricular diastolic function in patients with type 1 diabetes.
- Advanced Glycation end products in human optic nerve head
- Association between acute-phase reactants and Advanced Glycation end products in type 2 diabetes
- Plasma levels of soluble receptor for Advanced Glycation end products and coronary artery disease in nondiabetic men
- Detection of noncarboxymethyllysine and carboxymethyllysine Advanced Glycation end products (AGE) in serum of diabetic patients
- The receptor for Advanced Glycation end products is induced by the Glycationproducts themselves and tumor necrosis factor-α through nuclear factor-κB, and …
- Increased levels of Advanced Glycation end products in human cataractous lenses
- Expression of receptors for Advanced Glycation end products in peripheral occlusive vascular disease
- Lipid peroxidation and Advanced Glycation end products in the brain in normal aging and in Alzheimer’s disease
- Advanced Glycation end products in vitreous: Structural and functional implications for diabetic vitreopathy.
- Purification and characterization of mouse soluble receptor for Advanced Glycation end products (sRAGE)
- Relationship of serum Advanced Glycation end products with deterioration of periodontitis in type 2 diabetes patients
- Receptor for Advanced Glycation end-products is a marker of type I cell injury in acute lung injury
- Soluble receptor for Advanced Glycation end products in patients with decreased renal function
- Advanced Glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study
- Genotoxicity of Advanced Glycation end products in mammalian cells
- Identification of galectin-3 as a high-affinity binding protein for Advanced Glycation end products (AGE) : a new member of the AGE-receptor complex
- The receptor for Advanced Glycation end products is highly expressed in the skin and upregulated by Advanced Glycation end products and tumor necrosis …
- beta 2-Microglobulin modified with Advanced Glycation end products is a major component of hemodialysis-associated amyloidosis.
- Advanced Glycation end products in renal failure
- FEEL-1 and FEEL-2 are endocytic receptors for Advanced Glycation end products
- Expression of Advanced Glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease
- Activation of receptor for Advanced Glycation end products : a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis
- RAGE (receptor for Advanced Glycation end products ): a central player in the inflammatory response
- Advanced Glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses
- Immunochemical approach to characterize Advanced Glycation end products of the Maillard reaction: evidence for the presence of a common structure
- Increased proinflammatory endothelial response to S100A8/A9 after preactivation through Advanced Glycation end products
- Skin autofluorescence, a measure of cumulative metabolic stress and Advanced Glycation end products , predicts mortality in hemodialysis patients
- Advanced Glycation end products and their receptors co-localise in rat organs susceptible to diabetic microvascular injury
- Blockade of receptor for Advanced Glycation end-products restores effective wound healing in diabetic mice
- Impairment of vascular endothelial nitric oxide synthase activity by Advanced Glycation end products
- The breakdown of pre‐existing Advanced Glycation end products is associated with reduced renal fibrosis in experimental diabetes
- Induction of Advanced Glycation end products and alterations of the tensile properties of articular cartilage
- The role of Advanced Glycation end products in retinal microvascular leukostasis
- Advanced Glycation end products and nephrotoxicity of high-protein diets
- Receptor for Advanced Glycation end products (RAGE) regulates sepsis but not the adaptive immune response
- Scavenger receptors that recognize Advanced Glycation end products
- Immunochemical evidence for the presence of Advanced Glycation end products in human lens proteins and its positive correlation with aging.
- Increased Advanced Glycation end products in atherosclerotic lesions of patients with end-stage renal disease
- Specific fluorescence assay for Advanced Glycation end products in blood and urine of diabetic patients
- Decreased plasma levels of soluble receptor for Advanced Glycation end-products in patients with essential hypertension
- Receptor for Advanced Glycation end products -binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis
- Expression of receptors for Advanced Glycation end‐products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer
- Methylglyoxal-derived hydroimidazolone Advanced Glycation end-products of human lens proteins
- Immunohistochemical and ultrastructural detection of Advanced Glycation end products in atherosclerotic lesions of human aorta with a novel specific monoclonal …
- Increased accumulation of skin Advanced Glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy
- Age-related changes in cells and tissues due to Advanced Glycation end products (AGEs)
- Advanced Glycation end products induce blood–retinal barrier dysfunction in normoglycemic rats
- Advanced Glycation end products in Human Cancer Tissues: Detection of Nε‐(Carboxymethyl)lysine and Argpyrimidine
- Immunological evidence that non-carboxymethyllysine Advanced Glycation end-products are produced from short chain sugars and dicarbonyl compounds in …
- Receptor for Advanced Glycation end‐products is a marker of type I lung alveolar cells
- Age-and stage-dependent accumulation of Advanced Glycation end products in intracellular deposits in normal and Alzheimer’s disease brains
- Enzymatic digestion and mass spectrometry in the study of Advanced Glycation end products /peptides
- RAGE‐mediated neutrophil dysfunction is evoked by Advanced Glycation end products (AGEs)
- Advanced Glycation end products (AGEs)co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats.
- Diabetes increases formation of Advanced Glycation end products on Sarco (endo) plasmic reticulum Ca2+-ATPase
- Accumulation of Advanced Glycation end products in the peritoneal vasculature of continuous ambulatory peritoneal dialysis patients with low ultra-filtration.
- Advanced Glycation end products in clinical nephrology
- Increased serum concentrations of Advanced Glycation end products : a marker of coronary artery disease activity in type 2 diabetic patients
- The receptor for Advanced Glycation end products (RAGE) is a cellular binding site for amphoterin: mediation of neurite outgrowth and co-expression of rage …
- Immunohistochemical distribution of the receptor for Advanced Glycation end products in neurons and astrocytes in Alzheimer’s disease
- Crosslinking by Advanced Glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which …
- Rapid formation of Advanced Glycation end products by intermediate metabolites of glycolytic pathway and polyol pathway
- Oxidation conspires with Glycationto generate noxious Advanced Glycation end products in renal failure.
- Activation of the receptor for Advanced Glycation end products triggers a p21 ras-dependent mitogen-activated protein kinase pathway regulated by oxidant …
- Coregulation of neurite outgrowth and cell survival by amphoterin and S100 proteins through receptor for Advanced Glycation end products (RAGE) activation
- Receptor for Advanced Glycation end products , inflammation, and accelerated periodontal disease in diabetes: mechanisms and insights into therapeutic modalities
- Increased levels of serum Advanced Glycation end‐products in women with polycystic ovary syndrome
- Thiazolidinediones reduce endothelial expression of receptors for Advanced Glycation end products
- Advanced Glycation end products in human penis: elevation in diabetic tissue, site of deposition, and possible effect through iNOS or eNOS
- Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for Advanced Glycation end products
- Receptor for Advanced Glycation end products (RAGE) and its ligand, amphoterin are overexpressed and associated with prostate cancer development
- Serum levels of low molecular weight Advanced Glycation end products in diabetic subjects
- N ε-(carboxymethyl) lysine adducts of proteins are ligands for receptor for Advanced Glycation end products that activate cell signaling pathways and modulate …
- Tomato paste fraction inhibiting the formation of Advanced Glycation end-products
- Receptor for Advanced Glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-κB require the cytoplasmic domain of the receptor but …
- Advanced Glycation end products enhance expression of pro-apoptotic genes and stimulate fibroblast apoptosis through cytoplasmic and mitochondrial …
- Influence of Advanced Glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of β-amyloid peptide
- Advanced Glycation end products and Advancedoxidation protein products in hemodialyzed patients
- Role of Advanced Glycation end products (AGEs)and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy.
- The receptor for Advanced Glycation end-products has a central role in mediating the effects of Advanced Glycation end-products on the development of vascular …
- Advanced Glycation end products activate Smad signaling via TGF‐β‐dependent and‐independent mechanisms: implications for diabetic renal and vascular disease
- Advanced Glycation end products in uremia
- Articular chondrocytes express the receptor for Advanced Glycation end products : potential role in osteoarthritis
- Role of Advanced Glycation end products in adynamic bone disease in patients with diabetic nephropathy
- Advanced Glycation end products -induced apoptosis and overexpression of vascular endothelial growth factor in bovine retinal pericytes
- Role of Advanced Glycation end-products (AGE) in late diabetic complications
- Circulating levels of soluble receptor for Advanced Glycation end products in Alzheimer disease and vascular dementia
- Receptor for Advanced Glycation end products is involved in impaired angiogenic response in diabetes
- Advanced Glycation end products induce crosslinking of collagen in vitro
- Accumulation of Advanced Glycation end products , measured as skin autofluorescence, in renal disease
- At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by Advanced Glycation end products
- The receptor for Advanced Glycation end products and its ligands: a new inflammatory pathway in lung disease?
- Advanced Glycation end products in neurodegeneration: more than early markers of oxidative stress?
- Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic Advanced Glycation end-products: comparison with aminoguanidine
- Markedly elevated levels of plasma Advanced Glycation end products in patients with liver cirrhosis–amelioration by liver transplantation
- Co-expression of receptor for Advanced Glycation end products and the ligand amphoterin associates closely with metastasis of colorectal cancer
- Enhanced expression of receptor for Advanced Glycation end products in chronic kidney disease
- Alternative routes for the formation of immunochemically distinct Advanced Glycation end-products in vivo
- Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for Advanced Glycation end products blocks hyperpermeability in diabetic …
- Expression profiling of endogenous secretory receptor for Advanced Glycation end products in human organs
- 3-Deoxyglucosone, a promoter of Advanced Glycation end products in fluids for peritoneal dialysis
- Receptor for Advanced Glycation end products (AGEs)has a central role in vessel wall interactions and gene activation in response to circulating AGE proteins
- Advanced Glycation end products in end-stage renal disease and their removal
- Constitutive nitric oxide synthase expression in retinal vascular endothelial cells is suppressed by high glucose and Advanced Glycation end products .
- Novel splice variants of the receptor for Advanced Glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in …
- Receptor for Advanced Glycation end products and its ligands: a journey from the complications of diabetes to its pathogenesis
- Advanced Glycation end products induce expression of vascular endothelial growth factor by retinal Müller cells
- … system of human phagocytes generates Nε-(carboxymethyl)lysine on proteins: a mechanism for producing Advanced Glycation end products at sites of …
- Modulation of soluble receptor for Advanced Glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy
- … prevents macro-and microvascular endothelial dysfunction and oxidative stress following a meal rich in Advanced Glycation end products in individuals with type 2 …
- Nε-(Carboxymethyl)lysine Protein Adduct Is a Major Immunological Epitope in Proteins Modified with Advanced Glycation end products of the Maillard Reaction
- Inflammation-induced chondrocyte hypertrophy is driven by receptor for Advanced Glycation end products
- Reduced cell replication and induction of apoptosis by Advanced Glycation end products in rat Schwann cells
- Advanced Glycation end‐products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone
- Enhanced interaction of Advanced Glycation end products with their cellular receptor RAGE: implications for the pathogenesis of accelerated periodontal disease in …
- Accelerated nephropathy in diabetic apolipoprotein e-knockout mouse: role of Advanced Glycation end products
- Circulating soluble receptor for Advanced Glycation end products is inversely associated with glycemic control and S100A12 protein
- Formation of Advanced Glycation end products during CAPD
- Cd36, a member of the class b scavenger receptor family, as a receptor for Advanced Glycation end products
- Advanced Glycation end products -driven angiogenesis in vitro: induction of the growth and tube formation of human microvascular endothelial cells through …
- Advanced Glycation end products in serum predict changes in the kidney morphology of patients with insulin-dependent diabetes mellitus
- Decreased levels of soluble receptor for Advanced Glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control
- Increased methylglyoxal and Advanced Glycation end products in kidney from spontaneously hypertensive rats
- Advanced Glycation end products and vascular structure and function
- The receptor for Advanced Glycation end-products (RAGE) directly binds to ERK by a D-domain-like docking site
- Possible involvement of Advanced Glycation end-products in bone resorption
- Receptor for Advanced Glycation end products and age-related macular degeneration
- Advanced Glycation end products (AGEs)on the surface of diabetic erythrocytes bind to the vessel wall via a specific receptor inducing oxidant stress in the …
- Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of Advanced Glycation end products : biochemical …
- Anti-hypertensive agents inhibit in vivo the formation of Advanced Glycation end products and improve renal damage in a type 2 diabetic nephropathy rat model
- Advanced Glycation end products upregulate angiogenic and pro-inflammatory cytokine production in human monocyte/macrophages
- Accumulation of fructosyl-lysine and Advanced Glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats
- Evaluation of Advanced Glycation end products and carbonyl compounds in patients with different conditions of oxidative stress
- Macrophage scavenger receptor mediates the endocytic uptake and degradation of Advanced Glycation end products of the Maillard reaction
- Proteins modified by malondialdehyde, 4-hydroxynonenal, or Advanced Glycation end products in lipofuscin of human retinal pigment epithelium
- Down-regulation of the receptor for Advanced Glycation end-products (RAGE) supports non-small cell lung carcinoma
- Advanced Glycation end products induce tubular epithelial-myofibroblast transition through the RAGE-ERK1/2 MAP kinase signaling pathway
- Identification of polymorphisms in the receptor for Advanced Glycation end products (RAGE) gene: prevalence in type 2 diabetes and ethnic groups.
- Chronic diabetes increases Advanced Glycation end products on cardiac ryanodine receptors/calcium-release channels
- Induction of 1, 2-dicarbonyl compounds, intermediates in the formation of Advanced Glycation end-products, during heat-sterilization of glucose-based peritoneal …
- Plasma levels of Advanced Glycation end products in healthy, long-term vegetarians and subjects on a western mixed diet
- Corneal Advanced Glycation end products increase in patients with proliferative diabetic retinopathy
- Expression of receptor for Advanced Glycation end products and HMGB1/amphoterin in colorectal adenomas
- Regulation of cyclooxygenase-2 expression in monocytes by ligation of the receptor for Advanced Glycation end products
- Advanced Glycation end products inhibit de novo protein synthesis and induce TGF-β overexpression in proximal tubular cells
- Blockade of late stages of autoimmune diabetes by inhibition of the receptor for Advanced Glycation end products
- Inflammation and Advanced Glycation end products in uremia: Simple coexistence, potentiation or causal relationship?
- Effects of Advanced Glycation end-products on the proliferation and differentiation of osteoblast-like cells
- Effect of Advanced Glycation end-products on gene expression and synthesis of TNF-α and endothelial nitric oxide synthase by endothelial cells
- Expression of the receptor of Advanced Glycation end products in gingival tissues of type 2 diabetes patients with chronic periodontal disease: a study utilizing …
- Advanced Glycation end products are eliminated by scavenger-receptor-mediated endocytosis in hepatic sinusoidal Kupffer and endothelial cells
- Scavenger receptor class B type I-mediated reverse cholesterol transport is inhibited by Advanced Glycation end products
- Age‐related decrease in susceptibility of human articular cartilage to matrix metalloproteinase–mediated degradation: The role of Advanced Glycation end products
- Damage to the peritoneal membrane by glucose degradation products is mediated by the receptor for Advanced Glycation end-products
- N‐Glycans on the receptor for Advanced Glycation end products influence amphoterin binding and neurite outgrowth
- Advanced Glycation end-products in diabetic nephropathy
- Advanced Glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor β-independent …
- Glyceraldehyde-derived Advanced Glycation end products in Alzheimer’s disease
- Advanced Glycation end-products in patients with chronic alcohol misuse
- Receptor for Advanced Glycation end products mediates inflammation and enhanced expression of tissue factor in vasculature of diabetic apolipoprotein E–null mice
- Enhancing effect of Advanced Glycation end products on serotonin-induced platelet aggregation in patients with diabetes mellitus
- Familial amyloid polyneuropathy: receptor for Advanced Glycation end products -dependent triggering of neuronal inflammatory and apoptotic pathways
- Impaired retinal angiogenesis in diabetes: role of Advanced Glycation end products and galectin-3
- Low phagocytic activity of resident peritoneal macrophages in diabetic mice: relevance to the formation of Advanced Glycation end products .
- … production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for Advanced Glycation end products
- Effect of Advanced Glycation end products on accelerated apoptosis of retinal capillary cells under in vitro conditions
- Glyoxalase I deficiency is associated with an unusual level of Advanced Glycation end products in a hemodialysis patient
- Immunohistochemical localisation of Advanced Glycation end products in pulmonary fibrosis.
- Advanced Glycation end products enhance osteoclast-induced bone resorption in cultured mouse unfractionated bone cells and in rats implanted subcutaneously with …
- Accumulation of Advanced Glycation end products of the Maillard reaction with age in human hippocampal neurons
- Advanced Glycation end products induce apoptosis and procoagulant activity in cultured human umbilical vein endothelial cells
- Naphthopyrone glucosides from the seeds of Cassia tora with inhibitory activity on Advanced Glycation end products (AGEs)formation
- Immunohistochemical localization of Advanced Glycation end products , pentosidine, and carboxymethyllysine in lipofuscin pigments of Alzheimer’s disease and aged …
- Glycolaldehyde, a reactive intermediate for Advanced Glycation end products , plays an important role in the generation of an active ligand for the macrophage …
- Positive association of serum levels of Advanced Glycation end products with thrombogenic markers in humans
- High serum levels of Advanced Glycation end products predict increased coronary heart disease mortality in nondiabetic women but not in nondiabetic men: a …
- Expression of receptor for Advanced Glycation end products (RAGE) and MMP-9 in human pancreatic cancer cells.
- Advanced Glycation end products in children and adolescents with diabetes: relation to glycemic control and early microvascular complications
- Immunohistochemical localization of different epitopes of Advanced Glycation end products in human atherosclerotic lesions
- Advanced Glycation end‐products are responsible for the impairment of corpus cavernosal smooth muscle relaxation seen in diabetes
- In vitro formation of Advanced Glycation end products in peritoneal dialysis fluid
- Activation of receptor for Advanced Glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes
- Key role of Src kinase in S100B-induced activation of the receptor for Advanced Glycation end products in vascular smooth muscle cells
- The receptor for Advanced Glycation end products (RAGE) is a central mediator of the interaction of AGE-beta2microglobulin with human mononuclear phagocytes via …
- Immunochemical detection of Advanced Glycation end products in lens crystallins from streptozocin-induced diabetic rat
- Advanced Glycation end products in human senile and diabetic cataractous lenses
- Interaction of the receptor for Advanced Glycation end products (RAGE) with transthyretin triggers nuclear transcription factor kB (NF-kB) activation
- Accumulation of Advanced Glycation end products in women with preeclampsia: possible involvement of placental oxidative and nitrative stress
- Soluble receptor for Advanced Glycation end products triggers a proinflammatory cytokine cascade via β2 integrin Mac‐1
- Characterization of Advanced Glycation end products : mass changes in correlation to side chain modifications
- Up‐regulated expression of the receptor for Advanced Glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts
- High levels of dietary Advanced Glycation end products transform low-dersity lipoprotein into a potent redox-sensitive mitogen-activated protein kinase stimulant in …
- Membrane proteins of human erythrocytes are modified by Advanced Glycation end products during aging in the circulation
- Plasma levels of Advanced Glycation end products during haemodialysis, haemodiafiltration and haemofiltration: potential importance of dialysate quality
- … in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to Advanced Glycation end-products through binding of …
- Involvement of beta 2-microglobulin modified with Advanced Glycation end products in the pathogenesis of hemodialysis-associated amyloidosis. Induction of human …
- Advanced Glycation end products (AGE) and their receptor (RAGE) in the brain of patients with Creutzfeldt-Jakob disease with prion plaques.
- Histones from diabetic rats contain increased levels of Advanced Glycation end products
- Generation of active oxygen species from Advanced Glycation end-products (AGEs)during ultraviolet light A (UVA) irradiation and a possible mechanism for cell …
- Identification of pentosidine as a native structure for Advanced Glycation end products in beta-2-microglobulin-containing amyloid fibrils in patients with dialysis-related …
- Toxic action of Advanced Glycation end products on cultured retinal capillary pericytes and endothelial cells: relevance to diabetic retinopathy
- Effects of Advanced Glycation End-products on the Proliferation and Fibronectin Production of Smooth Muscle Cells
- The role of galectin-3 in endocytosis of Advanced Glycation end products and modified low density lipoproteins
- Acid-stable fluorescent Advanced Glycation end products : vesperlysines A, B, and C are formed as crosslinked products in the Maillard reaction between lysine or …
- Effect of Advanced Glycation end products on lens epithelial cells in vitro
- Possible participation of Advanced Glycation end products in the pathogenesis of colorectal cancer in diabetic patients
- Type II alveolar epithelial cells in lung express receptor for Advanced Glycation end products (RAGE) gene
- Expression of a novel secreted splice variant of the receptor for Advanced Glycation end products (RAGE) in human brain astrocytes and peripheral blood …
- Advanced Glycation end-products in diabetic nephropathy.
- Effect of buformin and metformin on formation of Advanced Glycation end products by methylglyoxal
- Association of expression of receptor for Advanced Glycation end products and invasive activity of oral squamous cell carcinoma
- Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for Advanced Glycation end products (AGE)
- Upregulation of mesangial growth factor and extracellular matrix synthesis by Advanced Glycation end products via a receptor-mediated mechanism
- Advanced Glycation end products induce angiogenesis in vivo
- Advanced Glycation end products in diabetic complications
- Expression and function of receptors for Advanced Glycation end products in bovine corneal endothelial cells
- Advanced Glycation end products -cytokine-nitric oxide sequence pathway in the development of diabetic nephropathy: aminoguanidine ameliorates the …
- Modification of enzymatic antioxidants in retinal microvascular cells by glucose or Advanced Glycation end products
- Deposition of Advanced Glycation end products (AGE) and expression of the receptor for AGE in cardiovascular tissue of the diabetic rat.
- Advanced Glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes
- High levels of soluble receptor for Advanced Glycation end products may be a marker of extreme longevity in humans
- Relationship between the expression of Advanced Glycation end-products (AGE) and the receptor for AGE (RAGE) mRNA in diabetic nephropathy
- Receptor for Advanced Glycation end products (RAGE) signaling induces CREB-dependent chromogranin expression during neuronal differentiation
- Candesartan reduced Advanced Glycation end-products accumulation and diminished nitro-oxidative stress in type 2 diabetic KK/Ta mice
- Advanced Glycation end-products induce apoptosis involving the signaling pathways of oxidative stress in bovine retinal pericytes
- Inhibition of human endothelial cell nitric oxide synthesis by Advanced Glycation end-products but not glucose: relevance to diabetes
- Accumulation of Advanced Glycation end products decreases collagen turnover by bovine chondrocytes
- … Advanced Glycation end products (RAGE) ligands is not sufficient to induce inflammatory signals: lack of activity of endotoxin-free albumin-derived Advanced…
- Synergistic action of Advanced Glycation end products and endogenous nitric oxide leads to neuronal apoptosis in vitro: a new insight into selective nitrergic …
- β2-Microglobulin modified with Advanced Glycation end products modulates collagen synthesis by human fibroblasts
- Advanced Glycation end products (AGEs) , free radicals and diabetes
- The role of reactive oxygen species in TNFα-dependent expression of the receptor for Advanced Glycation end products in human umbilical vein endothelial …
- Identification of the Advanced Glycation end products Nε-carboxymethyllysine in the synovial tissue of patients with rheumatoid arthritis
- Advanced Glycation end products can induce glial reaction and neuronal degeneration in retinal explants
- Elevation of Nε-(carboxymethyl) lysine-modified Advanced Glycation end products in chronic liver disease is an indicator of liver cirrhosis
- β2-Microglobulin modified with Advanced Glycation end products delays monocyte apoptosis
- From benefit to damage. Glutamate and Advanced Glycation end products in Alzheimer brain
- Constituents of the roots of Pueraria lobata inhibit formation of Advanced Glycation end products (AGEs)
- Atorvastatin decreases serum levels of Advanced Glycation end products (AGEs)in patients with type 2 diabetes
- Below the Radar: Advanced Glycation end products that Detour “around the side”: Is HbA1c not an accurate enough predictor of long term progression and …
- Roles of Advanced Glycation end-products in the progression of diabetic nephropathy
- Advanced Glycation end products induce choroidal endothelial cell proliferation, matrix metalloproteinase-2 and VEGF upregulation in vitro
- Increased expression of receptor for Advanced Glycation end products by synovial tissue macrophages in rheumatoid arthritis
- Effects of a diet rich in Advanced Glycation end products in the rat remnant kidney model
- Single exposure of mesothelial cells to glucose degradation products (GDPs) yields early Advanced Glycation end-products (AGEs)and a proinflammatory response
- cDNA cloning of a novel secreted isoform of the human receptor for Advanced Glycation end products and characterization of cells co-expressing cell-surface …
- Pigment epithelium-derived factor prevents Advanced Glycation end products -induced monocyte chemoattractant protein-1 production in microvascular …
- Thiamine corrects delayed replication and decreases production of lactate and Advanced Glycation end-products in bovine retinal and human umbilical vein …
- Inhibition of Advanced Glycation end‐products protects against retinal capillary basement membrane expansion during long‐term diabetes
- Advanced Glycation end products induce secretion of chemokines and apoptosis in human first trimester trophoblasts
- Serum levels of Advanced Glycation end products are associated with in-stent restenosis in diabetic patients
- Puerariafuran, a new inhibitor of Advanced Glycation end products (AGEs)isolated from the roots of Pueraria lobata
- … acid reduces expression of vascular cell adhesion molecule-1 and endothelial adhesion of human monocytes after stimulation with Advanced Glycation end products
- Advanced–Glycationend products in insulin-resistant states
- [11] Advanced Glycation end products : Detection and reversal
- Genotoxicity of Advanced Glycation end products : involvement of oxidative stress and of angiotensin II type 1 receptors
- Increased serum levels of Advanced Glycation end products (AGEs)in children and adolescents with IDDM
- High‐fat diet enhances visceral Advanced Glycation end products , nuclear O‐Glc‐Nac modification, p38 mitogen‐activated protein kinase activation and apoptosis
- Increased expression of Advanced Glycation end-products and their receptor, and activation of nuclear factor kappa-B in lacrimal glands of diabetic rats
- Advanced Glycation end products and oxidative stress are increased in chronic allograft nephropathy
- What’s the RAGE?: The receptor for Advanced Glycation end products (RAGE) and the dark side of glucose
- Are food Advanced Glycation end products toxic in biological systems?
- The endothelial cell binding site for Advanced Glycation end products consists of a complex: an integral membrane protein and a lactoferrin-like polypeptide
- Role of vitamin E-coated membrane in reducing Advanced Glycation end products in hemodialysis patients: a pilot study
- Bimodal effect of Advanced Glycation end products on mesangial cell proliferation is mediated by neutral ceramidase regulation and endogenous …
- Advanced Glycation end products in Diabetes‐Associated Atherosclerosis and Renal Disease: Interventional Studies
- Advanced Glycation end products and receptor for Advanced Glycation end products in AA amyloidosis
- Effect of Advanced Glycation end-products on cell proliferation and cell death
- Decreased levels of Advanced Glycation end-products in patients with Gilbert syndrome.
- Advanced Glycation end products increase collagen-specific chaperone protein in mouse diabetic nephropathy
- Effects of ramipril in nondiabetic nephropathy: improved parameters of oxidatives stress and potential modulation of Advanced Glycation end products
- Nitric oxide inhibits the formation of Advanced Glycation end products
- Blockade of the receptor for Advanced Glycation end products attenuates acetaminophen‐induced hepatotoxicity in mice
- Advanced Glycation end‐products in sickle cell anaemia
- The receptor for Advanced Glycation end products mediates the chemotaxis of rabbit smooth muscle cells
- Advanced Glycation end products (AGEs)and their receptor (RAGE) system in diabetic retinopathy
- Advanced Glycation end-products induce apoptosis of bovine retinal pericytes in culture: involvement of diacylglycerol/ceramide production and oxidative stress …
- Advanced Glycation end products co-localized with astrocytes and microglial cells in Alzheimer’s disease brain
- Advanced Glycation end products -induced gene expression of scavenger receptors in cultured human monocyte-derived macrophages
- Advanced Glycation end products and their recognition by macrophage and macrophage-derived cells
- Pigment epithelium-derived factor (PEDF) prevents diabetes-or Advanced Glycation end products (AGE) -elicited retinal leukostasis
- Significance of proximal tubular metabolism of Advanced Glycation end products in kidney diseases
- Are Advanced Glycation end products cardiovascular risk factors in patients with CRF?
- Telmisartan inhibits expression of a receptor for Advanced Glycation end products (RAGE) in angiotensin-II-exposed endothelial cells and decreases serum levels of …
- Low-molecular but not high-molecular Advanced Glycation end products (AGEs)are removed by high-flux dialysis.
- Impact of metabolic control and serum lipids on the concentration of Advanced Glycation end products in the serum of children and adolescents with type 1 diabetes …
- Immunochemical detection of Advanced Glycation end products in renal cortex from STZ-induced diabetic rat
- Advanced Glycation end products in children with chronic renal failure and type 1 diabetes
- Identification of the receptor for Advanced Glycation end products in synovial tissue of patients with rheumatoid arthritis
- Risk factors for chronic transplant dysfunction and cardiovascular disease are related to accumulation of Advanced Glycation end-products in renal transplant …
- Advanced Glycation end-products (AGEs)induce concerted changes in the osteoblastic expression of their receptor RAGE and in the activation of extracellular signal …
- Elevated release of sCD40L from platelets of diabetic patients by thrombin, glucose and Advanced Glycation end products
- CD36-mediated endocytic uptake of Advanced Glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes
- Advanced Glycation end-products and peritoneal sclerosis
- A developmental nephron deficit in rats is associated with increased susceptibility to a secondary renal injury due to Advanced Glycation end-products
- Suppression of nNOS expression in rat enteric neurones by the receptor for Advanced Glycation end‐products
- Advanced Glycation end‐products increase monocyte adhesion to retinal endothelial cells through vascular endothelial growth factor‐induced ICAM‐1 expression …
- Activation of astrocytes by Advanced Glycation end products : cytokines induction and nitric oxide release
- Advanced Glycation end products : a highly complex set of biologically relevant compounds detected by mass spectrometry
- Identification of mouse orthologue of endogenous secretory receptor for Advanced Glycation end-products: structure, function and expression
- Plasma levels of Advanced Glycation end products in children with renal disease
- Estimation of age of human cadavers by immunohistochemical assessment of Advanced Glycation end products in the hippocampus
- Autofluorescence characterization of Advanced Glycation end products of hemoglobin
- Regulation of receptor for Advanced Glycation end products during bleomycin-induced lung injury
- Transition Metal–Catalyzed Oxidation of Ascorbate in Human Cataract Extracts: Possible Role of Advanced Glycation end products
- The receptor for Advanced Glycation end products (RAGE) is elevated in women with preeclampsia
- … Nε-(carboxymethyl) lysine is impaired in mice deficient in NADPH oxidase: a role for phagocyte-derived oxidants in the formation of Advanced Glycation end products …
- Glycationand Advanced Glycation end-products in laboratory experiments in vivo and in vitro
- Kinetics of nonenzymatic Glycationof ribonuclease A leading to Advanced Glycation end products . Paradoxical inhibition by ribose leads to facile isolation of protein …
- Induction of aldose reductase in cultured human microvascular endothelial cells by Advanced Glycation end products
- The role of metal-catalyzed oxidation in the formation of Advanced Glycation end products : an in vitro study on collagen
- Age-dependent accumulation of Advanced Glycation end-products in adult Drosophila melanogaster
- Interaction between β2-microglobulin and Advanced Glycation end products in the development of dialysis related-amyloidosis
- Effect of Advanced Glycation end products on endotoxin-induced TNF-alpha, IL-1beta and IL-8 in human peripheral blood mononuclear cells.
- Advanced Glycation end products increase, through a protein kinase C-dependent pathway, vascular endothelial growth factor expression in retinal endothelial cells …
- Are Advanced Glycation end-products associated with amyloidosis in Alzheimer’s disease?
- Proliferative stimulus of lung fibroblasts on lung cancer cells is impaired by the receptor for Advanced Glycation end-products
- Advanced Glycation end products modulate the maturation and function of peripheral blood dendritic cells
- The amphoterin (HMGB1)/receptor for Advanced Glycation end products (RAGE) pair modulates myoblast proliferation, apoptosis, adhesiveness, migration …
- Incadronate disodium inhibits Advanced Glycation end products -induced angiogenesis in vitro
- Receptor for Advanced Glycation end products is a promising target of diabetic nephropathy
- Two immunochemical assays to measure Advanced Glycation end-products in serum from dialysis patients
- Expression of the receptor for Advanced Glycation end products in Huntington’s disease caudate nucleus
- Expression of receptor for Advanced Glycation end products (RAGE) in human biliary cancer cells.
- Selective formation of certain Advanced Glycation end products in spinal cord astrocytes of humans and mice with superoxide dismutase-1 mutation
- Pathophysiology of Advanced Glycation end-products in renal failure
- Chemoselective synthesis of peptides containing major Advanced Glycation end‐products of lysine and arginine
- Immunohistochemical distribution and subcellular localization of three distinct specific molecular structures of Advanced Glycation end products in human tissues.
- Immunohistochemical study of Advanced Glycation end products in aging and Alzheimer’s disease brain
- Inhibitory effect of metformin on formation of Advanced Glycation end products
- Acute modulation of albumin microvascular leakage by Advanced Glycation end products in microcirculation of diabetic rats in vivo.
- Dysfunction of dermal fibroblasts induced by Advanced Glycation end-products (AGEs)and the contribution of a nonspecific interaction with cell membrane and AGEs
- Relationship between autofluorescence and Advanced Glycation end products in diabetic lenses
- Role of Advanced Glycation end products in aging collagen
- Peroxisome proliferator-activated receptor γ down-regulates receptor for Advanced Glycation end products and inhibits smooth muscle cell proliferation in a diabetic …
- Role of megalin in endocytosis of Advanced Glycation end products : implications for a novel protein binding to both megalin and Advanced Glycation end products
- Receptor for Advanced Glycation end products on human synovial fibroblasts: role in the pathogenesis of dialysis-related amyloidosis
- The breakdown of preformed Advanced Glycation end products reverses erectile dysfunction in streptozotocin‐induced diabetic rats: Preventive versus curative …
- Activation of nicotinamide adenine dinucleotide phosphate (reduced form) oxidase by Advanced Glycation end products links oxidative stress to altered retinal …
- The effects of valsartan on the accumulation of circulating and renal Advanced Glycation end products in experimental diabetes
- Genomic damage in end-stage renal failure: potential involvement of Advanced Glycation end products and carbonyl stress
- Advanced Glycation end products in kidney transplant patients: a putative role in the development of chronic renal transplant dysfunction
- Low‐Molecular Weight Advanced Glycation end products : Markers of Tissue AGE Accumulation and More?
- Nifedipine inhibits gene expression of receptor for Advanced Glycation end products (RAGE) in endothelial cells by suppressing reactive oxygen species generation.
- Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and Advanced Glycation end products formation
- Substrates modified by Advanced Glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet …
- Serum or cerebrospinal fluid levels of glyceraldehyde-derived Advanced Glycation end products (AGEs)may be a promising biomarker for early detection of …
- In vitro effect of Advanced Glycation end‐products on human polymorphonuclear superoxide production
- Removal of Advanced Glycation end products in clinical renal failure by peritoneal dialysis and haemodialysis
- C-Reactive protein upregulates receptor for Advanced Glycation end products expression in human endothelial cells
- Immunohistochemical localization of Advanced Glycation end products in pinguecula
- Susceptibility of brain microvascular endothelial cells to Advanced Glycation end products -induced tissue factor upregulation is associated with intracellular reactive …
- Advanced Glycation end products in Descemet’s membrane and their effect on corneal endothelial cell
- Low molecular weight Advanced Glycation end products predict mortality in asymptomatic patients receiving chronic haemodialysis
- Advanced Glycation end products (AGE) -modified proteins and their potential relevance to atherosclerosis
- Phosphatidylinositol 3′-kinase-dependent activation of renal mesangial cell Ki-Ras and ERK by Advanced Glycation end products
- Selective inhibition by grape seed proanthocyanidin extracts of cell adhesion molecule expression induced by Advanced Glycation end products in endothelial cells
- Inhibitor for Advanced Glycation end products formation attenuates hypertension and oxidative damage in genetic hypertensive rats
- Insulin enhances macrophage scavenger receptor-mediated endocytic uptake of Advanced Glycation end products
- Serum levels of glucose-derived Advanced Glycation end products are associated with the severity of diabetic retinopathy in type 2 diabetic patients without renal …
- Differential expression of receptors for Advanced Glycation end‐products in peritoneal mesothelial cells exposed to glucose degradation products
- The− 374A allele of the receptor for Advanced Glycation end products gene is associated with a decreased risk of ischemic heart disease in African-Brazilians with …
- Isolation and characterization of Advanced Glycation end products derived from the in vitro reaction of ribose and collagen
- Aminoguanidine inhibits Advanced Glycation end products formation on beta2-microglobulin.
- Possible significance of Advanced Glycation end products in serum in end-stage renal disease and in late complications of diabetes
- Advanced Glycation and lipoxidation end products : role of reactive carbonyl compounds generated during carbohydrate and lipid metabolism
- Immunohistochemical distribution and quantitative biochemical detection of Advanced Glycation end products in fetal to adult rats and in rats with …
- Generation of active oxygen species from Advanced Glycation end-products (AGE) under ultraviolet light A (UVA) irradiation
- Aminoguanidine and metformin prevent the reduced rate of HDL-mediated cell cholesterol efflux induced by formation of Advanced Glycation end products
- Advanced Glycation end products Stimulate an Enhanced Neutrophil Respiratory Burst Mediated Through the Activation of Cytosolic Phospholipase A2 and …
- Modification of β2m with Advanced Glycation end products as observed in dialysis-related amyloidosis by 3-DG accumulating in uremic serum
- Role of Advanced Glycation end products and growth factors in peritoneal dysfunction in CAPD patients
- Advanced Glycation end-products (AGEs)in hyperglycemic patients
- Inhibition of matrix-induced bone differentiation by Advanced Glycation end-products in rats
- Distribution of the receptor for Advanced Glycation end products gene polymorphisms in patients with chronic periodontitis: a preliminary study
- Presence of dopa and amino acid hydroperoxides in proteins modified with Advanced Glycation end products (AGEs) : amino acid oxidation products as a possible …
- Induction of macrophage growth by Advanced Glycation end products of the Maillard reaction.
- Dietary bread crust Advanced Glycation end products bind to the receptor for AGEs in HEK‐293 kidney cells but are rapidly excreted after oral administration to healthy …
- Importance of homocysteine, lipoprotein (a) and non-classical cardiovascular risk factors (fibrinogen and Advanced Glycation end-products) for atherogenesis in …
- Effects of Advanced Glycation end products on cytosolic Ca2+ signaling of cultured human mesangial cells
- Blockade of angiotensin II receptors reduces the expression of receptors for Advanced Glycation end products in human endothelial cells
- Immunohistochemical detection of Advanced Glycation end products in dialysis-related amyloidosis
- Skin autofluorescence, a marker of Advanced Glycation end products and oxidative stress, is increased in recently preeclamptic women
- Monocyte/macrophage response to β2-microglobulin modified with Advanced Glycation end products
- Renal accumulation and clearance of Advanced Glycation end-products in type 2 diabetic nephropathy: effect of angiotensin-converting enzyme and …
- Advanced Glycation end products /Peptides: An in Vivo Investigation
- Receptor for Advanced Glycation end products and the cardiovascular complications of diabetes and beyond: lessons from AGEing
- Advanced Glycation end products : specific fluorescence changes of pentosidine-like compounds during short daily hemodialysis
- Detection of N epsilon-(carboxymethyl) lysine (CML) and non-CML Advanced Glycation end-products in the anterior horn of amyotrophic lateral sclerosis spinal cord.
- Hepatic clearance of Advanced Glycation end products (AGEs) —myth or truth?
- 3-Deoxyosone-related Advanced Glycation end products in foods and biological systems
- Immunohistochemical study of human Advanced Glycation end-products (AGE) and growth factors in cardiac tissues of patients on maintenance dialysis and with …
- Mechanisms involved in the stimulatory effect of Advanced Glycation end products on growth of rat aortic smooth muscle cells
- Induction of reactive oxygen species and cell survival in the presence of Advanced Glycation end products and similar structures
- … and reduced viability of Alzheimer’s disease neuronal cybrids is reproduced by β-amyloid peptide acting through receptor for Advanced Glycation end products (RAGE …
- Advanced Glycation end products and hyperglycaemia
- Developmental expression of receptor for Advanced Glycation end products (RAGE), amphoterin and sulfoglucuronyl (HNK‐1) carbohydrate in mouse cerebellum and …
- Advanced Glycation end products impair the scavenger function of rat hepatic sinusoidal endothelial cells
- Rheumatoid arthritis: links with cardiovascular disease and the receptor for Advanced Glycation end products
- Receptor for Advanced Glycation end products plays a more important role in cellular survival than in neurite outgrowth during retinoic acid-induced …
- Expression and purification of the soluble isoform of human receptor for Advanced Glycation end products (sRAGE) from Pichia pastoris
- The amino-terminal domains of the ezrin, radixin, and moesin (ERM) proteins bind Advanced Glycation end products , an interaction that may play a role in the …
- Inhibition of nitric oxide synthase activity by early and Advanced Glycation end products in cultured rabbit proximal tubular epithelial cells
- Accurate mass measurements by Fourier transform mass spectrometry in the study of Advanced Glycation end products /peptides
- Benfotiamine inhibits intracellular formation of Advanced Glycation end products in vivo
- Effect of high-dose thiamine and pyridoxine on Advanced Glycation end products and other oxidative stress markers in hemodialysis patients: a randomized placebo …
- Advanced Glycation end products -modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36
- β2-Microglobulin modified with Advanced Glycation end products induces interleukin-6 from human macrophages: Role in the pathogenesis of hemodialysis …
- Amyloidosis, Advanced Glycation end products and Alzheimer disease
- Increased serum levels of Advanced Glycation end products in NIDDM patients with diabetic complications
- New hypothesis on etiopathogenesis of Alzheimer syndrome. Advanced Glycation end products (AGEs)
- Signalling pathways involved in retinal endothelial cell proliferation induced by Advanced Glycation end products : inhibitory effect of gliclazide
- N-Terminal pyrazinones: a new class of peptide-bound Advanced Glycation end-products
- Beraprost sodium, a prostaglandin I 2 analogue, protects against Advanced Glycation end products -induced injury in cultured retinal pericytes
- Neurotoxicity of acetaldehyde-derived Advanced Glycation end products for cultured cortical neurons
- The-429 T/C and-374 T/A gene polymorphisms of the receptor of Advanced Glycation end products gene are not risk factors for diabetic retinopathy in Caucasians with …
- Advanced Glycation end products modulate transcriptional regulation in mesangial cells
- Effects of Advanced Glycation end products on hyaluronan photolysis: a new mechanism of diabetic vitreopathy
- Receptors for Advanced Glycation end-products (AGE) —expression by endothelial cells in non-diabetic uraemic patients
- a-Series gangliosides mediate the effects of Advanced Glycation end products on pericyte and mesangial cell proliferation: a common mediator for retinal and renal …
- Graded sensitiveness of the various retinal neuron populations on the glyoxal-mediated formation of Advanced Glycation end products and ways of protection
- Advanced Glycation end-products downregulating intervertebral disc cell production of proteoglycans in vitro
- Amino acids injure mesangial cells by Advanced Glycation end products , oxidative stress, and protein kinase C
- Advanced Glycation end products stimulate tumor necrosis factor-alpha and interleukin-1 beta secretion by peritoneal macrophages in patients on continuous …
- Endocytic uptake of Advanced Glycation end products by mouse liver sinusoidal endothelial cells is mediated by a scavenger receptor distinct from the macrophage …
- Augmentation of the neutrophil respiratory burst through the action of Advanced Glycation end products : a potential contributor to vascular oxidant stress
- Reactive oxygen species accelerate production of vascular endothelial growth factor by Advanced Glycation end products in RAW264. 7 mouse macrophages
- Aminoguanidine inhibits albuminuria, but not the formation of Advanced Glycation end-products in skin collagen of diabetic rats
- The induction of surface β-amyloid binding proteins and enhanced cytotoxicity in cultured PC-12 and IMR-32 cells by Advanced Glycation end products
- Immunochemical evidence for increased formation of Advanced Glycation end products and inhibition by aminoguanidine in diabetic rat lenses
- In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for Advanced Glycation end products …
- Potential benefit of inhibitors of Advanced Glycation end products in the progression of type II diabetes: a study with aminoguanidine in C57/BLKsJ diabetic mice
- Advanced Glycation end products of the Maillard reaction in aortic pepsin-insoluble and pepsin-soluble collagen from diabetic rats
- Enhanced plasma levels of Advanced Glycation end products (AGE) and pro-inflammatory cytokines in children/adolescents with chronic renal insufficiency and after …
- Advanced Glycation end products induce death of retinal neurons via activation of nitric oxide synthase
- Effects of eparlestat on plasma levels of Advanced Glycation end products in patients with type 2 diabetes.
- Antibodies to Advanced Glycation end products in children with diabetes mellitus
- The human and rat recombinant receptors for Advanced Glycation end products have a high degree of homology but different pharmacokinetic properties in rats
- Epitopes close to the apolipoprotein B low density lipoprotein receptor-binding site are modified by Advanced Glycation end products
- Nuclear factor-κB and Advanced Glycation end-products expression in lacrimal glands of aging rats
- Cytotoxicity of acetaldehyde‐derived Advanced Glycation end‐products (AA‐AGE) in alcoholic‐induced neuronal degeneration
- Rapid determination of Advanced Glycation end products of proteins using MALDI-TOF-MS and PERL script peptide searching algorithm
- Pathogenic role of Advanced Glycation end-products (AGEs) : an overview
- The–429 T/C and–374 T/A gene polymorphisms of the receptor of Advanced Glycation end products gene (RAGE) are not risk factors for coronary artery disease in …
- Damaging effects of Advanced Glycation end-products in the murine macrophage cell line J774A. 1
- Advanced Glycation end products induce actin rearrangement and subsequent hyperpermeability of endothelial cells THIS ARTICLE HAS BEEN RETRACTED
- The effect of Advanced Glycation end-products and aminoguanidine on TNFα production by rat peritoneal macrophages
- Early and Advanced Glycation end-products are increased in dietary copper deficiency
- Gene polymorphisms (G82S, 1704G/T, 2184A/G and 2245G/A) of the receptor of Advanced Glycation end products (RAGE) in plaque psoriasis
- Advanced Glycation end-products as a potential target for treatment of cardiovascular disease
- Advanced Glycation end-products in the peritoneal fluid and in the peritoneal membrane of continuous ambulant peritoneal dialysis patients
- Mechanism of Advanced Glycation end products -induced hyperpermeability in endothelial cells
- Advanced Glycation end products in adolescents and young adults with diabetic angiopathy
- Ribozyme targeting of receptor for Advanced Glycation end products in mouse mesangial cells
- In vitro nonenzymatic Glycationof DNA nucleobases: an evaluation of Advanced Glycation end products under alkaline pH
- Effect of Advanced Glycation end products on oxidative stress in endothelial cells in culture: a warning on the use of cells studied in serum-free media
- Chemistry and Biological Effects of Melanoidins and Glyceraldehyde‐Derived Pyridinium as Advanced Glycation end products
- Expression of receptors for Advanced Glycation end-products in occlusive vascular and renal disease
- Advanced Glycation end products and the pathogenesis of diabetic nephropathy
- Advanced Glycation end products of the Maillard reaction and their relation to aging
- Detection of DNA‐bound Advanced Glycation end‐products by immunoaffinity chromatography coupled to HPLC‐diode array detection
- Induction of an aging mRNA retinal pigment epithelial cell phenotype by matrix-containing Advanced Glycation end products in vitro
- Pathological significance and mechanism of Advanced Glycation end-products [J]
- Differential expression of receptors for Advanced Glycation end products on monocytes in patients with IDDM
- Inhibitory effects of amlodipine and fluvastatin on the deposition of Advanced Glycation end products in aortic wall of cholesterol and fructose-fed rabbits
- Advanced Glycation end products (AGE) and the receptor for AGE are present in gastrointestinal tract of familial amyloidotic polyneuropathy patients but do not induce …
- Distribution of Advanced Glycation end products in the cerebellar neurons of dogs
- A food chemist’s view of Advanced Glycation end-products
- Screening of Korea Traditional Herbal Medicines with Inhibitory Activity on Advanced Glycation end products (AGEs)Formation
- Identification of Advanced Glycation end products of the Maillard reaction in Pick’s disease
- Influence of hemodialysis membrane permeability on serum levels of Advanced Glycation end products (AGEs)and homocysteine metabolites.
- Angiogenic effects of Advanced Glycation end products of the Maillard reaction on cultured human umbilical cord vein endothelial cells
- Identification of monoclonal antibody of Advanced Glycation end products
- Advanced Glycation end products potentiate the stimulatory effect of glucose on macrophage lipoprotein lipase expression
- Serum levels of 3-deoxyglucosone and tissue contents of Advanced Glycation end products are increased in streptozotocin-induced diabetic rats with nephropathy
- Serum levels of Advanced Glycation end products in poorly metabolically controlled children with diabetes mellitus: relation to HbA1c.
- Pentosidine in Advanced Glycation end-products (AGEs)during UVA irradiation generates active oxygen species and impairs human dermal fibroblasts
- Overexpression of receptor of Advanced Glycation end products hypersensitizes cells for amyloid beta peptide-induced cell death
- Immunolocalization and quantification of Advanced Glycation end products in retinal neovascular membranes and serum: a possible role in ocular neovascularization
- Study of the− 429 T/C and− 374 T/A receptor for Advanced Glycation end products promoter polymorphisms in diabetic and nondiabetic subjects with macrovascular …
- Advanced Glycation end products in peritoneal dialysis
- Analysis of serum of patients with Alzheimer’s disease for the level of Advanced Glycation end products
- Hemodialysis techniques and Advanced Glycation end products
- Cardiovascular risk in patients with end-stage renal disease: a potential role for Advanced Glycation end products
- Hereditary ceruloplasmin deficiency increases Advanced Glycation end products in the brain
- AU-rich elements in the mRNA 3′-untranslated region of the rat receptor for Advanced Glycation end products and their relevance to mRNA stability
- Local application of Advanced Glycation end products and intimal hyperplasia in the rabbit collared carotid artery
- Association of Advanced Glycation end products with A549 cells, a human pulmonary epithelial cell line, is mediated by a receptor distinct from the scavenger receptor …
- Immunolocalization of lipid peroxidation/Advanced Glycation end products in amyloid A amyloidosis
- Advanced Glycation end products : a possible link to angiotensin in an animal model
- Inhibition by Advanced Glycation end products (AGEs)of pigment epithelium-derived factor (PEDF) gene expression in microvascular endothelial cells.
- Ultrastructural changes and immunohistochemical localization of nitric oxide synthase, Advanced Glycation end products and NF-κB in aorta of streptozotocin treated …
- Glyceraldehyde-derived Advanced Glycation end-products preferentially induce VEGF expression and reduce GDNF expression in human astrocytes
- Importance of Advanced Glycation end products –AGE products
- Advanced Glycation end products inhibit tubulogenesis and migration of kidney epithelial cells in an ezrin-dependent manner
- Advanced Glycation end products (AGEs) ‐induced expression of TGF‐β1 is suppressed by a protease in the tubule cell line LLC‐PK1
- … of erythroleukaemia cell differentiation by extracellular high-mobility group-box protein 1 is independent of the receptor for Advanced Glycation end-products
- Advanced Glycation end-products/peptides: a preliminary investigation by LC and LC/MS
- Advanced Glycation end products impair protein turnover in LLC-PK1: Amelioration by trypsin
- Suppressive effects of tea polyphenol and conformational changes with receptor for Advanced Glycation end products (RAGE) expression in human hepatoma cells.
- Increased expression of tissue factor and receptor for Advanced Glycation end products in peripheral blood mononuclear cells of patients with type 2 diabetes mellitus …
- High glucose and Advanced Glycation end products induce phospholipid hydrolysis and phospholipid enzyme inhibition in bovine retinal pericytes
- Pathological significance and mechanism of Advanced Glycation end-products
- Ultrastructural localization of Advanced Glycation end products and beta2-microglobulin in dialysis amyloidosis.
- Diabetic nephropathy and Advanced Glycation end products
- Effect of intraperitoneal administration of heparin on Advanced Glycation end-products in CAPD
- Determination of Advanced Glycation end products
- … factor and interleukin-18 in maintenance hemodialysis patients: comparative study of Advanced Glycation end products , carboxymethyllysine and pentosidine
- Glycosphingolipid changes induced by Advanced Glycation end-products
- Mass spectrometry of Advanced Glycation end products
- N‐phenacylthiazolium bromide decreases renal and increases urinary Advanced Glycation end products excretion without ameliorating diabetic nephropathy in …
- Advanced Glycation end-products in anterior chamber aqueous of cataractous patients
- Advanced Glycation end products quench nitric oxide in vitro
- Oleate, not ligands of the receptor for Advanced Glycation end-products, promotes proliferation of human arterial smooth muscle cells
- Advanced Glycation end products accelerate atherosclerosis via enhancement of oxidative stress
- Advanced Glycation end products are involved in microvascular permeability changes observed in microcirculation of diabetic rats in vivo
- Advanced Glycation end products induce specific glycoprotein alterations in retinal microvascular cells
- Cloning and characterization of the canine receptor for Advanced Glycation end products
- Phototransformations of Advanced Glycation end products in the human eye lens due to ultraviolet A light irradiation
- Ultrastructural changes and immunohistochemical localization of Advanced Glycation end products in the heart of streptozotocin-treated Mongolian gerbils
- Advanced Glycation end-products prepared in solution under high pressure contain epitopes distinct from those formed in the dry reaction at high temperature
- Advanced Glycation end-products in corneas of patients with keratoconus
- Studies on Advanced Glycation end products by recent mass spectrometric techniques
- Amyloid, Advanced Glycation end products , and dialysis related arthropathy
- Constituents of the stems of Rumex japonicus with Advanced Glycation end products (AGEs)and rat lens aldose reductase (RLAR) inhibitory activity
- Experimental effect of Puerarin on the formation of Advanced Glycation end products and expression of RAGE in the arota of diabetic rats [J]
- Advanced Glycation end products stimulate plasminogen activator activity via GM-CSF in RAW 264.7 cells
- Advanced Glycation end products , their receptors and diabetic angiopathy
- Molecular heterogeneity of amyloid β2-microglobulin and modification with Advanced Glycation end products
- Proliferation-inhibiting effect of Advanced Glycation end products modified human serum albumin to vascular endothelial cell ecv304
- Advanced Glycation end-products reduce the viability of human peritoneal mesothelial cells
- Protective effects of carnosine and relative compounds on DNA cleavage by Advanced Glycation end products
- Intraperitoneal infusion of glucose-based dialysate in the rat—an animal model for the study of peritoneal Advanced Glycation end-products formation and effect on …
- Relationship between vascular endothelial growth factors and Advanced Glycation end products in the human vitreous
- Nitric oxide, Advanced Glycation end products , and uremia
- Role of lipid peroxidation products in the formation of Advanced Glycation end products : An in vitro study on collagen
- Localization of Advanced Glycation end products of Maillard reaction in bovine tissues and their endocytosis by macrophage scavenger receptors
- … radical trapping and carbonyl group trapping anti-AGE agent: a pyridoxamine analogue for inhibiting Advanced Glycation (AGE) and lipoxidation (ALE) end products
- Advanced Glycation end products and β2-microglobulin. The story unfolds
- Advanced Glycation and lipoxidation end products : reactive carbonyl compounds‐related uraemic toxicity
- In vitro-prepared Advanced Glycation end-products and the modulating potential of their low-molecular weight degradation products in IRPTC-A rat proximal-tubular …
- Lipid peroxidation, Advanced Glycation end products and antioxidant status in patients on dialysis
- The relation between impaired wound healing and Advanced Glycation end products [J]
- New aspects in the pathogenesis of dialysis-related amyloidosis: pathophysiology of Advanced Glycation end products in renal failure
- Formation of Advanced Glycation end (AGE) products in diabetes: Prevention by pyruvate and a-keto glutarate
- Advanced Glycation end products inhibit production of nitric oxide by human endothelial cells through activation of the p38 signal pathway
- Expression of receptor for Advanced Glycation end products during rat tongue carcinogenesis by 4-nitroquinoline 1-oxide and effect of a selective cyclooxygenase-2 …
- Effects of Advanced Glycation end products on Ezrin‐Dependent Functions in LLC‐PK1 Proximal Tubule Cells
- Induction of GM-CSF production of macrophages by Advanced Glycation end products of the Maillard reaction
- Immunohistochemical study with anti‐Advanced Glycation end‐products antibody in murine amyloidosis
- Advanced Glycation end products in hemodialyzed patients with diabetes mellitus correlate with leptin and leptin/body fat ratio
- Decrease in the glyceraldehyde derived Advanced Glycation end products in the sera of patients with Vogt-Koyanagi-Harada disease
- Increased levels of circulating Advanced Glycation end products in a model of acute renal insufficiency in rats
- … renal biopsy samples in patients with diabetic nephropathy in non‐insulin dependent diabetes mellitus using monoclonal antibody to Advanced Glycation end products
- Protective effect of inducible type nitric oxide synthase against intracellular oxidative stress caused by Advanced Glycation end-products in vascular smooth muscle …
- Crossline-like structure accumulates as fluorescent Advanced Glycation end products in renal tissues of rats with diabetic nephropathy
- Hepatocyte growth factor protects against apoptosis induced by Advanced Glycation end products in endothelial cells.
- Experimental effect of Puerarin on the formation of Advanced Glycation end products and expression of RAGE in the arota of diabetic rats
- RAGE engagement and vascular cell derangement by short chain sugar-derived Advanced Glycation end products
- Evidence for accumulation of Advanced Glycation end products in acute renal failure
- Advanced Glycation end products (AGEs)and renal failure
- Recombinant human interleukin-10 inhibits proliferation of vascular smooth muscle cells stimulated by Advanced Glycation end products and neointima hyperplasia …
- Advanced Glycation end products stimulate human endothelial cells to produce monocyte chemoattractant protein-1
- Immunochemical determination of Advanced Glycation end products in erythrocyte peripheral-membrane proteins from diabetic patients
- Effects of Advanced Glycation end-products on cell cycle distribution and apoptosis in neonatal rat cardiac myocytes
- Activation of smad signaling and collagenⅠ synthesis in NRK52E cells induced by Advanced Glycation end products
- Inhibitory effect of dilazep hydrochloride on the formation of Advanced Glycation end products
- Activation of receptor for Advanced Glycation end products : a mechanism for monocyte-mediated inflammation in chronic renal failure
- The Mechanism of Advanced Glycation end products -Induced Morphological Changes of Tight Junction in Endothelial Cell
- Inhibitory effect of peptide-free forms of Advanced Glycation end products on the proliferation and extracellular matrix protein production of cultured cells
- Advanced Glycation end products and coronary heart disease in type 2 diabetes.
- Formation and ways of detecting Advanced Glycation end-products in isolated human glomerular basement membrane and human serum albumin nonenzymatically …
- Advanced Glycation end products induce apoptosis and expression of apoptotic genes in cultured bovine retinal capillary pericytes
- Intracellular changes in astrocytes and NG 108-15 neuroblastoma X glioma cells induced by Advanced Glycation end products
- Sodium sulfite and N-acetylcysteine: new additives to dialysate for inhibiting formation of glucose degradation products and Advanced Glycation end-products
- Mass Spectrum in the Study of Advanced Glycation end products
- Diabetic erythrocytes bearing Advanced Glycation end products induce vascular dysfunctions
- … Use of Solid Phase Extraction Cartridges as a Pre-Fractionation Step in the Quantisation of Intermolecular Collagen Crosslinks and Advanced Glycation End-Products
- Effect of Advanced Glycation end products on rat aortic vascular smooth muscle cells
- In vitro glycoxidation of insoluble fibrous type I collagen: solubilization and Advanced Glycation end products
- Expression and function of receptors for Advanced Glycation end products in bovine corneal endothelial cells
- Expression of receptors for Advanced Glycation end products at surface of peripheral blood monocytes and relationship thereof to plasma proinflammatory cytokines in …
- Advanced Glycation end products in intervertebral discs and hip joint capsules: Correlation with senile amyloid?
- Effects of flavone from leaves of Diospyros kaki on adventitial fibroblast proliferation induced by Advanced Glycation end-products in vitro
- Effects of Advanced Glycation End-products on Expression of Peroxisome Proliferator Activated Receptor-γ mRNA in Cultured Human Vascular Endothelial Cells [J]
- A modulatory role for Advanced Glycation end-products (AGEs)in retinal microvascular leukostasis
- Molecular mechanism of diabetic retinopathy: role of Advanced Glycation end products (AGEs)and their receptor (RAGE) in the pathogenesis of diabetic retinopathy
- Advanced Glycation end products -induced TNF-α and IL-6 production by peripheral lymphocytes of diabetic patients [J]
- Effects of tonifying shen recipe on Advanced Glycation end products , amyloid-beta peptide in telencephalon and hippocampus of ovariectomized rats
- Screening of natural resources with inhibitory activity on free radicals and Advanced Glycation end products (AGEs)formation
- Effects of Advanced Glycation end products on oxidative stress in endothelial cells
- Immunohistochemistry of Advanced Glycation end products in neurofilamentous axonal spheroids induced by β-β′-iminodipropionitrile in lower motor neurons of rat
- The pathobiological effect of β_2-microglobulin modified with Advanced Glycation end products on human type B synovial cells [J]
- Effects of Advanced Glycation end products on changes of glomerulus of STZ-induced diabetic rat
- Recombinant human interleukin-10 inhibits proliferation of rat vascular smooth muscle cells stimulated by Advanced Glycation end products [J]
- The Effect of Advanced Glycation end products on Macrophage Matrix Metalloproteinase-9 Activity and the Intervention Effect of Simvastatin
- AGE (Advanced Glycation end products ) receptors in age–related macular degeneration
- Advanced Glycation end products and pseudoexfoliation–correlation between clinical outcome and histological findings
- Effects of Advanced Glycation end products on the expression of plasminogen activator inhibitor-1 in rat mesangial cells [J]
- Advanced Glycation end-products and diabetic renal disease
- The changes of Advanced Glycation end products in a rat liver fibrosis model and the interventional effect of aminoguanidin
- Effect of Advanced Glycation end products (AGEs)on proliferation of vascular endothelial cells cultured in vitro
- Evaluation of Advanced Glycation End–Products in Diabetic and Inherited Canine Cataracts
- Effect of Wenjintong Composita on mRNA expression of receptor of the Advanced Glycation end products in sciatic nerve of streptozotocin-induced diabetic rats
- Advanced Glycation end products induce apoptosis in corneal endothelium
- Effects of carvedilol and metoprolol on plasma Advanced Glycation end products (AGE) and Advancedoxidation protein products (AOPP) in patients with chronic heart …
- Inhibitory effect of pycnogenol on generation of Advanced Glycation end products in vitro
- Expression of Advanced Glycation end products receptors on human joint synovial cells
- Elevated Level of Imidazolone and Pyrraline, Major Components of Advanced Glycation end products , in the Vitreous Fluid of Patients With Diabetic Retinopathy
- Effects of Advanced Glycation end products on activity and expression of eNOS in human umbilical vein endothelial cells
- Effects of Advanced Glycation end products and hypoxia on endothelin-1 secretion by bovine retinal microvascular pericytes
- Non-invasive assessment of Advanced Glycation end products , markers of oxidative stress, in recently preeclamptic women
- In vitro effects of flavone from leaves of Diospyros kaki on rat cardiac myocyte apoptosis induced by hypoxia-reoxygenation and Advanced Glycation end products .
- Effect of Different Advanced Glycation end products on Proliferation of Vascular Smooth Muscle Cell
- Advanced Glycation end products in Nephrology
- A new model of age-related macular degeneration induced by Advanced Glycation end products
- Dietary Copper Deficiency Causes Elevation of Early and Advanced Glycation End-Products
- Effects of Advanced Glycation end products on the activity of NF-kappaB and the expression of fibronectin mRNA in the endothelial cells in aged rats
- Polymorphism 2184A/G in the gene encoding Receptor of Advanced Glycation end products (RAGE) is a newly identified risk factor for diabetic nephropathy
- Influence of Advanced Glycation end-products in the development of atherosclerosis
- Relation between dialysis-related amyloidosis and Advanced Glycation end products (AGEs)
- Advanced Glycation end products -induced TNF-? and IL-6 production by peripheral lymphocytes of diabetic patients
- Structure and function of the metal-binding protein S100B and its interaction with the receptor for Advanced Glycation end products
- Monocyte/macrophage receptors for proteins modified by Advanced Glycation end products : role in normal tissue remodeling and in pathology
- The Correlation Between Serum Advanced Glycation end products and Nitric Oxide Levels in Type 2 Diabetes and Chronic Complications of Diabetes
- Alterations of retinal microvascular cell glycoproteins by Advanced Glycation end products
- Immunohistochemical localization of Advanced Glycation end products in pinguecula.
- Inhibitory effects of extracts from Ginkgo biloba and grape seed on the generation of Advanced Glycation end products in vitro
- Pattern of CTGF mRNA expression induced by Advanced Glycation end products in mesangial cells [J]
- Advanced Glycation end-products-LDL stimulates adhesion molecule expression by human aortic endothelial cells
- Accelerated Aging in Glaucoma: Immunohistochemical Assessment of Advanced Glycation End–Products in the Human Retina and Optic Nerve Head
- Effects of perindopril on expression of transformation growth factor-β type receptorⅡ in cultured human vascular endothelial cells by Advanced Glycation end products
- Advanced Glycation end products and senile dementia
- Recombinant Lapemis hardwickii phospholipase A2 inhibits rat vascular smooth muscle cell proliferation stimulated by Advanced Glycation end products
- Advanced Glycation end products Act As A Skin Tumor Initiator in Mice
- Enzyme-linked immunosorbent assay development for Advanced Glycation end products and brochocin-C.
- Role of peroxisome proliferators activated receptor gamma in mediating proliferation of rat vascular smooth muscle cells induced by Advanced Glycation end products
- Effects of Advanced Glycation end products on protein and mRNA expression of macrophage inflammatory protein-1α in cultured human umbilical vein endothelial …
- The correlation between the Advanced Glycation end products (AGEs-P) and diabetic retinopathy
- Proteolysis of the receptor for Advanced Glycation end products by matrix metalloproteinases
- Effects of Advanced Glycation end products on osteoblastic cells
- Advanced Glycation end-products induce global endothelial activation
- Interaction of reactive oxygen species in atherogenetic properties of Advanced Glycation end products in diabetes
- Effects of crocetin on formation of Advanced Glycation end products and expression of releptor for Advanced Glycation and prodmts protein in diabetic rats
- Advanced Glycation end products in urine: Are some sugar-derived products better than others?
- Effect of quercetin on generation of Advanced Glycation end products in vitro
- 39. Synthesis of Labelled Advanced Glycation end products Using N-Succinimidyl 4-[18F] Fluorobenzoate
- Effects of Advanced Glycation end products on Rat Bladder Fibroblast
- Effect of Advanced Glycation end products on inflammation in cultured cardiomyocytes
- Diet and diabetes, Advanced Glycation end products or AGEs
- Deposition of Advanced Glycation end products in Climatic Droplet Keratopathy
- Advanced Glycation end products (AGEs)related complications in diabetic nephropathy
- Hypertension and Atherosclerosis: Advanced Glycation end products —A Common Link
- PREVENTION OF THE MAILLARD REACTION AND REVERSIBLE DESTRUCTION OF Advanced Glycation end products (AGE) BY NOVEL ORGANIC …
- EFFECTS OF Advanced Glycation end products (AGEs)ON ADHESION AND MULTIPLICATION IN E. coli
- Effects of Advanced Glycation end products on the expression of ICAM-1 and VCAM-1 in ECV-304 cells
- Effects of Advanced Glycation end products on expression and activity of PAI-1 in rat renal cortex
- The effect of exogenous Advanced Glycation end products on the alteration of visual evoked potential in the rats
- Expression of receptor for Advanced Glycation end products (RAGE) and its ligands S100/calgranulins and amphoterin is increased in the vitreous cavity of patients …
- Immunological Approach to Advanced Glycation end products of The Maillard Reaction
- Role of Advanced Glycation end products (AGE) in the development of diabetic microangiopathies and the beneficial effects of AGE inhibitors
- Effects of Advanced Glycation end-products on skin keratinocytes by NF-? B activation
- Advanced Glycation end products accumulate in the diabetic gallbladder
- THE ACCUMULATION OF Advanced Glycation end products IN THE EXTRINSIC MAMBRANE FRACTIONS OF HUMAN CATARACTOUS LENSES [J]
- Advanced Glycation end products are Associated With Diabetic Peripheral Macrovascular Complications
- Inhibition of Inflammation due to Advanced Glycation End‐products by Pentoxifylline
- Serum levels of Advanced Glycation end products are associated with in-stent restenosis in diabetic patients
- Endocytosis of Advanced Glycation end products in Bovine Choriocapillary Endothelial Cells
- Effects of Advanced Glycation end products on activi ty and expression of matrix metalloproteinase-2 in renal cortex of rats
- Impaired glucose tolerance, angiopathy and Advanced Glycation end products
- Effects of vitamin E on secretion of inflammatory mediators of human monocytes by Advanced Glycation end products
- The presence and activity of the receptor for Advanced Glycation end products in osteoblasts
- Glycationof basement membranes: Location of Advanced Glycation end products within type IV collagen and their effect on degradation by matrix proteases.
- Advanced Glycation end products MODIFIED PROTEIN UP-REGULATES EXPRESSION OF ADHESION MOLECULES ON HUMAN ENDOTHELIAL CELLS
- Role of Advanced Glycation end products (AGEs)in diabetic cardiovascular and renal disease
- Gly82Ser polymorphism in the receptor for Advanced Glycation end products (RAGE) gene is not associated with the progression of diabetic nephropathy and …
- Biodistribution of the 18F-labelled Advanced Glycation end products Nε-carboxymethyllysine (CML) and Nε-carboxyethyllysine (CEL)
- 298 INVERSE RELATIONSHIP BETWEEN Advanced Glycation end products AND GLUTATHIONE IN SICKLE CELL ANEMIA
- EXPRESSION AND REGULATION OF THE BINDING PROTEINS FOR Advanced Glycation end products ON HUMAN JOINT SYNOVIAL CELLS
- Glyoxalase I deficiency is associated with an unusual level of Advanced Glycation end products in a hemodialysis patient
- Response to ‘Do Advanced Glycation end products and glucose induce similar signaling events in mesangial cells?’
- Advanced Glycation end products cross-links and diabetic-induced endothelium dysfunction
- Advanced Glycation end products (AGEs)Reduce Vesicular Transport in RPE Cells
- EFFECTS OF VITAMIN C AND VITAMIN E ON RECEPTORS OF Advanced Glycation end products IN EXPERIMENTAL DIABETIC RATS [J]
- Advanced Glycation end products (AGE) enhance vascular endothelial growth factor (VEGF) production in promonocytic leukaemia THP-1 cells
- Induction of Age-related Macular Degeneration (AMD) by Advanced Glycation End (AGE) Products and S100B
- The Accumulation of Advanced Glycation end products in the Retinal Pigment Epithelium and in Bruch’s membrane of human donors.
- Heparin blocks the binding of Advanced Glycation end products to its receptors on human monocytes
- Advanced Glycation end products and Loss of Pericytes in Early Diabetic Retinopathy
- Advanced Glycation end products AND AdvancedOXIDATION PROTEIN PRODUCTION IN PATIENTS WITH AA AMYLOIDOSIS
- 3.3 INHIBITON OF PROTEIN GlycationAND Advanced Glycation end products BY FOODSTATE® VITAMIN C AND OTHER VITAMINS AND …
- Effects of Advanced Glycation end products on peroxisome proliferator activated receptor-? mRNA expression in rat renal cortex
- Advanced Glycation end products induce proliferation of vascular smooth muscle cells and antagonism of drugs
- Effects of Advanced Glycation end products on the expression of plasminogen activator inhibitor-1 in rat mesangial cells
- Formation of Advanced Glycation end products by glyceraldehyde and glyceraldehyde-3-phosphate with proteins.
- P9 Participation of Advanced Glycation end products in actinic elastosis
- Advanced Glycation end products (AGEs)lower the clearance function of hepatic scavenger endothelial cells (SEC)
- Diabetic erythrocytes bearing Advanced Glycation end products (AGE) bind to the receptor for age and increase vascular permeability
- ; EFFECT OF HIGH CONCENTRATION GLUCOSE AND Advanced Glycation end products ONMIP-1α mRNA EXPRESSION IN CULTURED HUMAN …
- Effect of high concentration glucose and Advanced Glycation end products on MIP-1# alpha# mRNA expression in cultured human umbilical vein endothelial cells
- Relationship between the Advanced Glycation end products content and expressions of RAGE, ICAM-1 in vascular tissue of diabetic rats
- Biodistribution of the {sup 18} F-labelled Advanced Glycation end products N {sup {epsilon}}-carboxymethyllysine (CML) and N {sup {epsilon}}-carboxyethyllysine (CEL …
- Effects of Advanced Glycation end products on the survival and the morphology of bovine retinal endothelial cells and pericytes
- Advanced Glycation end products (AGEs)Induce Glomerular Sclerosis and Albuminuria in Normal Rats
- Effects of Advanced Glycation end products on glycosphingolipids of retinal pericytes
- < SYMPOSIUM: Biology of Aging and Age-associated Skin Disorders> POSSIBLE ROLES OF Advanced Glycation END-PRODUCTS IN PROMOTING SKIN …
- Effects of Advanced Glycation end products on protein and mRNA expression of macrophage inflammatory protein-1? in cultured human umbilical vein endothelial …
- Advanced Glycation end products -induced inflammatory reaction in human monocytes: cellular receptor pathway & intracellu-lar signaling
- Vector construction for the intracellular domain of human receptor for Advanced Glycation end-products and expression of the fusion protein
- Effects of Wen-Jin-Tong on the formation of Advanced Glycation end products and expressions of RAGE and ICAM-1 in cardiovascular tissues of diabetic rats
- The Receptor for Advanced Glycation end products Is Induced by the GlycationProducts Themselves and Tumor Necrosis Factor-α through Nuclear Factor-κB, and by …
- Advanced Glycation end products Induce Expression of Vascular Endothelial Growth Factor by Retinal Müller Cells.
- Mechanism of migration of vascular adventitial fibroblasts enhanced by Advanced Glycation end-products and the inhibition effect of candesartan
- Advanced Glycation end products MEDIATE ANG II-DEPENDENT PRO-INFLAMMATORY RESPONSES IN A TRANSGENIC RAT MODEL: 2C. 5
- Effects of Probenecid on the Elimination of the Advanced Glycation End-products Ne-Carboxymethyllysine (CML) and Ne-Carboxyethyllysine (CEL) Using …
- Rapid Communication: Blockade of Angiotensin II Receptors Reduces the Expression of Receptors for Advanced Glycation end products in Human Endothelial Cells
- Immunohistochemical demonstration of Advanced Glycation end products in synovial amyloid deposits of patients on long-term hemodialysis
- Advanced Glycation end products Increases U937 Macrophages Expression of Scavenger Receptor Class B Type I
- Inhibitory effects of extracts from {\sl Ginkgo biloba} and grape seed on the generation of Advanced Glycation end products {\sl in vitro}
- Effects of tetramethylpyrazine on the expression of nuclear factorkappa B induced by Advanced Glycation end products in retinal pigment epithelium
- Naphthopyrone Glucosides from the Seeds of Cassia tora with Inhibitory Activity on Advanced Glycation end products (AGEs)Formation
- MOLECULAR ANALYSIS OF RECEPTOR FOR Advanced Glycation END-PRODUCTS ISOFORMS EXPRESSED IN TISSUES AND CELL LINES.: 123
- Effect of aminoguanidine on mRNA expression of specific receptor of the Advanced Glycation end products in diabetic kidney tissue in rats
- Puerarin reduces serum levels of Advanced Glycation end products and monocyte chemoattractant protein-1 in diabetic rats
- Advanced Glycation end products -induced MCP-1 expression via its receptor RAGE in mouse podocytes
- N-acetylcysteine inhibits Advanced Glycation end products -induced VCAM-1 expression in mouse cardiac microvascular endothelial cells
- Inhibition of green tea polyphenols on proliferation of rat vascular smooth muscle cells stimulated by Advanced Glycation end products
- Localization of Advanced Glycation end products (AGE) in actinic elastosis.
- Advanced Glycation end products induce actin rearrangement and subsequent hyperpermeability in endothelial cells
- Macrophage Scavenger Receptor Mediates The Endocytic Uptake of Advanced Glycation end products (AGEs)
- Galectin-3,[Beta]-Galactoside-Binding Lectin, as a Receptor for Advanced Glycation end products
- Modification of enzymatic antioxidants in bovine retinal capillary pericytes by Advanced Glycation end products
- A 24-nor-Triterpenoid from the Steins of Rumex japonicus with Advanced Glycation End-products (AGEs)Inhibitory Activity
- Receptor for Advanced Glycation end products (RAGE) in Pulmonary Fibrosis
- Ginkgo biloba extract attenuates Advanced Glycation end products -induced TGF-? _1, CTGF mRNA expression and oxidative stress in NRK-49F cells
- Regulation of adhesion molecule expression on retinal capillary endothelium by exposure to high glucose: a role for Advanced Glycation end–products (AGEs) ?
- Effects of Advanced Glycation end-products on expression of acyl coenzyme A: cholesterol acyltransferase-1 in THP-1 macrophages
- Role of Advanced Glycation end products in TGF-β1 and Fibronectin Expression in Mesangial Cells Cultured under High Glucose
- Angiotensin-Converting Enzyme Inhibition Influences Serum Levels of Advanced Glycation end products in Patients with Coronary Artery Disease: Results from a …
- Insulin Accelerates the Endocytic Uptake and Degradation of Advanced Glycation End-Products Mediated by The Macrophage Scavenger Receptor
- Functional Hyperhomocysteinemia in Healthy Vegetar-ians: No Association with Advanced Glycation end products , Markers of Protein Oxidation, or Lipid …
- Advanced Glycation end products (AGEs)exacerbate NAFLD progression to liver fibrosis via receptor for AGEs (RAGE) in high fat fed mice
- Identification of N ε carboxymethyl lysine as a native structure for Advanced Glycation end products in circulation and amyloid fibrils in chronic hemodialysis patients
- Advanced Glycation end products and thiobarbituric acid reactive substance in gingival tissues of diabetic and non-diabetic patients with chronic periodontitis
- The inflammatory and immunogenic properties of the receptor for Advanced Glycation end products and its ligand, high mobility group box chromosomal …
- Screening and identification of proteins that interact with receptor for Advanced Glycation end products (RAGE) via T7 select phage display system
- Inhibition of Diabetic Leukostasis and Blood–Retinal Barrier Breakdown With a Soluble Form of a Receptor for Advanced Glycation end products
- SUPPRESSION OF Advanced Glycation AND LIPOXIDATION end products BY AN ANGIOTENSIN II TYPE-1 RECEPTOR BLOCKER IN ESSENTIAL …
- Superoxide Mediates Through ERK Signaling TGF-β1 Expression in Rat Kidney Proximal Tubule Epithelial Cells Treated with Advanced Glycation end products
- Effects of Advanced Glycation end products on expression of scavenger receptor class B type I (SR-BI) in U937 macrophages
- Essential role of receptor for Advanced Glycation end products (RAGE) in the inflammatory response and mucosal injury after hemorrhagic shock (HS)
- … System (RAS) Inhibits Increased Matrix Metalloproteinase-9 Expression and Apoptosis Induced by Advanced Glycation end products (AGE) and Attenuates Receptor …
- Small Interfering RNA (siRNA) Targeting Receptor for Advanced Glycation end products (RAGE) Downregulates Stromal Cell Derived Factor 1 (SDF-1) in …
- The role of Advanced Glycation end products in progression and complications of diabetes
- Advanced Glycation end products in foods and a practical guide to their reduction in the diet
- Advanced Glycation end‐products and the kidney
- Dietary Advanced Glycation end products and aging
- Does accumulation of Advanced Glycation end products contribute to the aging phenotype?
- Advanced Glycation end products and insulin resistance
- The road to Advanced Glycation end products : a mechanistic perspective
- Advanced Glycation end products , diabetes and ageing
- Role of Advanced Glycation end products in diabetic neuropathy
- Advanced Glycation end‐products (AGEs)and heart failure: pathophysiology and clinical implications
- Advanced Glycation end products , oxidative stress and diabetic nephropathy
- Advanced Glycation end products and diabetic foot disease
- Possible involvement of Advanced Glycation end-products (AGEs)in the pathogenesis of Alzheimer’s disease
- Mechanisms of disease: Advanced Glycation end-products and their receptor in inflammation and diabetes complications
- Advanced Glycation end-products: implications for diabetic and non-diabetic nephropathies
- Advanced Glycation end-products and arterial stiffness in hypertension
- Advanced Glycation end-products (AGEs) : involvement in aging and in neurodegenerative diseases
- The role of Advanced Glycation end products in retinal ageing and disease
- Advanced Glycation end products (AGEs)and their involvement in liver disease
- Advanced Glycation end-products and bone fractures
- Calcitriol blunts the deleterious impact of Advanced Glycation end products on endothelial cells
- Advanced Glycation end products and cardiovascular disease
- Food-derived Advanced Glycation end products (AGEs) : a novel therapeutic target for various disorders
- Collagen, cross-linking, and Advanced Glycation end products in aging human skeletal muscle
- Trends in Advanced Glycation end products research in diabetes mellitus and its complications
- Plasma receptor for Advanced Glycation end products and clinical outcomes in acute lung injury
- Soluble form of a receptor for Advanced Glycation end products (sRAGE) as a biomarker.
- The receptor for Advanced Glycation end products (RAGE) and the lung
- Significance of Advanced Glycation end products in aging-related disease
- A role for the receptor for Advanced Glycation end products in idiopathic pulmonary fibrosis
- Rutin metabolites: novel inhibitors of nonoxidative Advanced Glycation end products
- Role of Advanced Glycation end products (AGEs)and oxidative stress in diabetic retinopathy
- Clinical and prognostic value of Advanced Glycation end-products in chronic heart failure
- Receptor for Advanced Glycation end products (RAGEs) and experimental diabetic neuropathy
- Elevated levels of serum Advanced Glycation end products in patients with non‐alcoholic steatohepatitis
- The role of the receptor for Advanced Glycation end-products in lung fibrosis
- Advanced Glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways
- Dietary Advanced Glycation end products –a risk to human health? A call for an interdisciplinary debate
- Receptor for Advanced Glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes
- The extracellular region of the receptor for Advanced Glycation end products is composed of two independent structural units
- Role of Advanced Glycation end products in hypertension and atherosclerosis: therapeutic implications
- Advanced Glycation end products in renal failure: an overview
- Receptor for Advanced Glycation end products activation injures primary sensory neurons via oxidative stress
- Soluble receptor for Advanced Glycation end products : a new biomarker in diagnosis and prognosis of chronic inflammatory diseases
- Advanced Glycation end products and antioxidant status in type 2 diabetic patients with and without peripheral artery disease
- Inhibitory effects of Chrysanthemum species extracts on formation of Advanced Glycation end products
- Advanced Glycation end products increases matrix metalloproteinase-1,-3, and-13, and TNF-α in human osteoarthritic chondrocytes
- Advanced Glycation end products accumulate in the reproductive tract of men with diabetes
- Advanced Glycation end products enhance the proliferation and activation of hepatic stellate cells
- Structural basis for pattern recognition by the receptor for Advanced Glycation end products (RAGE)
- Receptor for Advanced Glycation end products is subjected to protein ectodomain shedding by metalloproteinases
- Advanced Glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells
- Single oral challenge by Advanced Glycation end products acutely impairs endothelial function in diabetic and nondiabetic subjects
- Elevated serum Advanced Glycation end products and poor grip strength in older community-dwelling women
- Elevation of soluble form of receptor for Advanced Glycation end products (sRAGE) in diabetic subjects with coronary artery disease
- Advanced Glycation end-products enhance calcification in vascular smooth muscle cells
- Effect of pyridoxamine (K-163), an inhibitor of Advanced Glycation end products , on type 2 diabetic nephropathy in KK-Ay/Ta mice
- Expression of high-mobility group box 1 and of receptor for Advanced Glycation end products in chronic obstructive pulmonary disease
- Advanced Glycation end products attenuate cellular insulin sensitivity by increasing the generation of intracellular reactive oxygen species in adipocytes
- Plasma Advanced Glycation end products are decreased in obese children compared with lean controls
- Hyperglycemia-induced reactive oxygen species increase expression of the receptor for Advanced Glycation end products (RAGE) and RAGE ligands
- Advanced Glycation end products strongly activate platelets
- Role of soluble receptor for Advanced Glycation end products on endotoxin-induced lung injury
- Effects of Advanced Glycation end products on the expression of COX-2, PGE2 and NO in human osteoarthritic chondrocytes
- Endothelial dysfunction in patients with chronic kidney disease results from Advanced Glycation end products (AGE) -mediated inhibition of endothelial nitric oxide …
- Advanced Glycation end-products induce tubular CTGF via TGF-β–independent Smad3 signaling
- Protection against loss of innate defenses in adulthood by low Advanced Glycation end products (AGE) intake: role of the antiinflammatory AGE receptor-1
- Advanced Glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes
- Homodimerization is essential for the receptor for Advanced Glycation end products (RAGE)-mediated signal transduction
- Advanced Glycation end products and receptor–oxidative stress system in diabetic vascular complications
- Interactions between Advanced Glycation end-products (AGE) and their receptors in the development and progression of diabetic nephropathy-are these receptors …
- Immunohistochemical localization of Advanced Glycation end-products (AGEs)and their receptor (RAGE) in polycystic and normal ovaries
- Role of Toll-like receptors 2 and 4, and the receptor for Advanced Glycation end products in high-mobility group box 1–induced inflammation in vivo
- Serum levels of sRAGE, the soluble form of receptor for Advanced Glycation end products , are associated with inflammatory markers in patients with type 2 …
- Increased serum Advanced Glycation end‐products is a distinct finding in lean women with polycystic ovary syndrome (PCOS)
- Advanced Glycation end products enhance amyloid precursor protein expression by inducing reactive oxygen species
- Advanced Glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women
- Advanced Glycation end products as biomarkers and gerontotoxins–a basis to explore methylglyoxal-lowering agents for Alzheimer’s disease?
- Accumulation of Advanced Glycation end products and chronic complications in ESRD treated by dialysis
- Advanced Glycation end products induce calcification of vascular smooth muscle cells through RAGE/p38 MAPK
- The receptor for Advanced Glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival
- Receptor for Advanced Glycation end-products (RAGE) and soluble RAGE (sRAGE): cardiovascular implications
- Accelerated aging in glaucoma: immunohistochemical assessment of Advanced Glycation end products in the human retina and optic nerve head
- Advanced Glycation end products depress function of endothelial progenitor cells via p38 and ERK 1/2 mitogen-activated protein kinase pathways
- S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for Advanced Glycation end products
- Role of Advanced Glycation end products with oxidative stress in resistance artery dysfunction in type 2 diabetic mice
- Effects of atorvastatin on serum soluble receptors for Advanced Glycation end-products in type 2 diabetes
- Plasma levels of receptor for Advanced Glycation end products , blood transfusion, and risk of primary graft dysfunction
- Convergence and amplification of toll-like receptor (TLR) and receptor for Advanced Glycation end products (RAGE) signaling pathways via high mobility group B1 …
- Advanced Glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway
- Involvement of Advanced Glycation end products in the pathogenesis of diabetic complications: the protective role of regular physical activity
- Receptor for Advanced Glycation end products : fundamental roles in the inflammatory response: winding the way to the pathogenesis of endothelial …
- Association between circulating soluble receptor for Advanced Glycation end products and atherosclerosis: observations from the Dallas Heart Study
- Advanced Glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription factor
- Deletion of the receptor for Advanced Glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse
- Receptor for Advanced Glycation end products (RAGE) in a dash to the rescue: inflammatory signals gone awry in the primal response to stress
- Receptor for Advanced Glycation end products (RAGE): a novel therapeutic target for diabetic vascular complication
- Astragalosides isolated from the root of astragalus radix inhibit the formation of Advanced Glycation end products
- Chondroprotective effects and mechanisms of resveratrol in Advanced Glycation end products -stimulated chondrocytes
- Higher plasma soluble receptor for Advanced Glycation end products (sRAGE) levels are associated with incident cardiovascular disease and all-cause mortality in …
- Alternative splicing of the murine receptor for Advanced Glycation end‐products (RAGE) gene
- … enhances the proinflammatory activity of lipopolysaccharide by promoting the phosphorylation of MAPK p38 through receptor for Advanced Glycation end products
- Dihydrochalcones: Implication in resistance to oxidative stress and bioactivities against Advanced Glycation end-products and vasoconstriction
- Effects of Advanced Glycation end products on renal fibrosis and oxidative stress in cultured NRK-49F cells
- Receptor for Advanced Glycation end products (RAGE)—soluble form (sRAGE) and gene polymorphisms in patients with breast cancer
- Cancer malignancy is enhanced by glyceraldehyde-derived Advanced Glycation end-products
- In skeletal muscle Advanced Glycation end products (AGEs)inhibit insulin action and induce the formation of multimolecular complexes including the receptor …
- Advanced Glycation end products (AGEs)activate mast cells
- The combination of high glucose and Advanced Glycation end-products (AGEs)inhibits the mineralization of osteoblastic MC3T3-E1 cells through glucose-induced …
- Distribution of the receptor for Advanced Glycation end products in the human male reproductive tract: prevalence in men with diabetes mellitus
- Advanced Glycation end products in senile diabetic and nondiabetic patients with cataract
- Role of the receptor for Advanced Glycation end products in hepatic fibrosis
- Thiazolidinedione increases serum soluble receptor for Advanced Glycation end-products in type 2 diabetes
- Advanced Glycation end products impair function of late endothelial progenitor cells through effects on protein kinase Akt and cyclooxygenase-2
- Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for Advanced Glycation end products
- Advanced Glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase
- Plasma protein Advanced Glycation end products , carboxymethyl cysteine, and carboxyethyl cysteine, are elevated and related to nephropathy in patients with …
- Inhibitors of aldose reductase and Advanced Glycation end-products formation from the leaves of Stelechocarpus cauliflorus RE Fr.
- Immunological detection of fructose-derived Advanced Glycation end-products
- Receptor for Advanced Glycation end products expression on T cells contributes to antigen-specific cellular expansion in vivo
- Receptor for Advanced Glycation end products : its role in Alzheimer’s disease and other neurological diseases
- Advanced Glycation end-products induce cell cycle arrest and hypertrophy in podocytes
- Decreased formation of Advanced Glycation end-products in peritoneal fluid by carnosine and related peptides
- S100B and S100A6 differentially modulate cell survival by interacting with distinct RAGE (receptor for Advanced Glycation end products ) immunoglobulin …
- Inhibitors of Advanced Glycation end products (AGEs) : potential utility for the treatment of cardiovascular disease
- … of Advanced Glycation end products levels are related to ischaemic aetiology and extent of coronary disease in chronic heart failure patients, independent of Advanced…
- Circulating soluble receptor for Advanced Glycation end products is inversely associated with body mass index and waist/hip ratio in the general population
- The expression of receptor for Advanced Glycation end products is associated with angiogenesis in human oral squamous cell carcinoma
- Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for Advanced Glycation end products
- The receptor for Advanced Glycation end products impairs host defense in pneumococcal pneumonia
- Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by Advanced Glycation end products
- Hyperglycaemia-induced pro-inflammatory responses by retinal Müller glia are regulated by the receptor for Advanced Glycation end-products (RAGE)
- Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by Advanced Glycation end-products
- Solution Structure of the Variable-Type Domain of the Receptor for Advanced Glycation end products : New Insight into AGE−RAGE Interaction,
- Advanced Glycation end-products affect transcription factors regulating insulin gene expression
- Receptor for Advanced Glycation end products is detrimental during influenza A virus pneumonia
- Opposing effects of bisphosphonates and Advanced Glycation end-products on osteoblastic cells
- Decrease in serum levels of Advanced Glycation end-products by short-term lifestyle modification in non-diabetic middle-aged females
- Receptor for Advanced Glycation end products (RAGE) soluble form (sRAGE): a new biomarker for lung cancer
- Receptors for Advanced Glycation end-products targeting protect against hyperoxia-induced lung injury in mice
- A novel function of the receptor for Advanced Glycation end-products (RAGE) in association with tumorigenesis and tumor differentiation of HCC
- Receptor for Advanced Glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury
- Advanced Glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells
- Association of polymorphism in the receptor for Advanced Glycation end products (RAGE) gene with circulating RAGE levels
- Induction of apoptosis of β cells of the pancreas by Advanced Glycation end‐products, important mediators of chronic complications of diabetes mellitus
- … Glycationend products on stored red blood cells increase endothelial reactive oxygen species generation through interaction with receptor for Advanced Glycation end …
- Anti-receptor for Advanced Glycation end products therapies as novel treatment for abdominal aortic aneurysm
- Advanced Glycation end products and their circulating receptors and level of kidney function in older community-dwelling women
- Possible involvement of Advanced Glycation end products in periodontal diseases
- Kinetics, role and therapeutic implications of endogenous soluble form of receptor for Advanced Glycation end products (sRAGE) in diabetes
- ERM protein moesin is phosphorylated by Advanced Glycation end products and modulates endothelial permeability
- S100B Interaction With the Receptor for Advanced Glycation end products (RAGE) A Novel Receptor-Mediated Mechanism for Myocyte Apoptosis Postinfarction
- Hypoxia-inducible factor-1 mediates neuronal expression of the receptor for Advanced Glycation end products following hypoxia/ischemia
- Soluble receptor for Advanced Glycation end products in physiological and pathological pregnancy
- Receptor for Advanced Glycation end products —soluble form and gene polymorphisms in chronic haemodialysis patients
- Role of the receptor for Advanced Glycation end products (RAGE) in inflammation
- Serum levels of soluble receptor for Advanced Glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk …
- Decreased plasma levels of soluble receptor for Advanced Glycation end products in mild cognitive impairment
- Advanced Glycation end products Inhibit Glucose-Stimulated Insulin Secretion through Nitric Oxide-Dependent Inhibition of Cytochrome c Oxidase and Adenosine …
- Citrus Fruit Extracts Reduce Advanced Glycation end products (AGEs) – and H2O2-Induced Oxidative Stress in Human Adipocytes
- Glutaraldehyde is an effective cross-linker for production of antibodies against Advanced Glycation end-products
- Soluble Receptor for Advanced Glycation end products (RAGE) is a prognostic factor for heart failure
- Short-term low calorie diet intervention reduces serum Advanced Glycation end products in healthy overweight or obese adults
- The formation of intracellular glyceraldehyde-derived Advanced Glycation end-products and cytotoxicity
- … increase is associated with skeletal muscle immunostaining for Advanced Glycation end products , receptor for Advanced Glycation end products , and oxidation injury
- Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for Advanced Glycation end products and potentiates inflammation with highly homologous but …
- Advanced Glycation end products in patients with cerebral infarction
- Serum levels of soluble form of receptor for Advanced Glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in …
- The role of Advanced Glycation end-products (AGEs)in the development of vascular diabetic complications
- Soluble receptors for Advanced Glycation end products (sRAGE) as a predictor of restenosis following percutaneous coronary intervention
- Advanced Glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina
- Evidence for activation of Toll-like receptor and receptor for Advanced Glycation end products in preterm birth
- Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by Advanced Glycation end products in cultured mouse …
- Smooth muscle cell pathophysiology and Advanced Glycation end products (AGEs)
- An in vitro model to test the contribution of Advanced Glycation end products to bone biomechanical properties
- The receptor for Advanced Glycation end products (RAGE) system in women with intraamniotic infection and inflammation
- Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, Advanced Glycation end products and oxidative stress in alloxan …
- Association of the Gly82Ser polymorphism in the receptor for Advanced Glycation end products (RAGE) gene with circulating levels of soluble RAGE and inflammatory …
- Gly82Ser polymorphism of the receptor for Advanced Glycation end products is associated with an increased risk of gastric cancer in a Chinese population
- Do Advanced Glycation end products contribute to the development of long-term diabetic complications?
- Low serum level of the endogenous secretory receptor for Advanced Glycation end products (esRAGE) is a risk factor for prevalent vertebral fractures independent of …
- Advanced Glycation end products inhibit the expression of collagens type I and III by human gingival fibroblasts
- Advanced Glycation end products assessed by skin autofluorescence in type 1 diabetics are associated with nephropathy, but not retinopathy
- Circulating Advanced Glycation end products (AGEs)and soluble form of receptor for AGEs (sRAGE) are independent determinants of serum monocyte …
- Advanced Glycation end products induce in vitro cross‐linking of α‐synuclein and accelerate the process of intracellular inclusion body formation
- Advanced Glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy?
- Receptor for Advanced Glycation end-products (RAGE) modulates neutrophil adhesion and migration on glycoxidated extracellular matrix
- Olmesartan blocks inflammatory reactions in endothelial cells evoked by Advanced Glycation end products by suppressing generation of reactive oxygen species
- Plasma levels of Advanced Glycation end products are associated with haemolysis‐related organ complications in sickle cell patients
- Plasma receptor for Advanced Glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation
- Receptor for Advanced Glycation end products Facilitates Host Defense during Escherichia coli–Induced Abdominal Sepsis in Mice
- Metformin reduces endothelial cell expression of both the receptor for Advanced Glycation end products and lectin-like oxidized receptor 1
- … -to-basolateral transport of amyloid-β peptides through blood-brain barrier cells is mediated by the receptor for Advanced Glycation end-products and is restricted by P …
- Elevated levels of the receptor for Advanced Glycation end products , a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in …
- Ribosylation rapidly induces α-synuclein to form highly cytotoxic molten globules of Advanced Glycation end products
- Monocyte CD147 is induced by Advanced Glycation end products and high glucose concentration: possible role in diabetic complications
- Biologic variability in plasma glucose, hemoglobin A1c, and Advanced Glycation end products associated with diabetes complications
- Identifying Advanced Glycation end products as a major source of oxidants in aging: implications for the management and/or prevention of reduced renal function in …
- Blockade of PKC-beta protects HUVEC from Advanced Glycation end products induced inflammation
- Effect of circulating soluble receptor for Advanced Glycation end products (sRAGE) and the proinflammatory RAGE ligand (EN-RAGE, S100A12) on mortality in …
- Plasma concentrations of high-mobility group box protein 1, soluble receptor for Advanced Glycation end-products and circulating DNA in patients with acute …
- Glycated albumin, a precursor of Advanced Glycation end‐products, up‐regulates NADPH oxidase and enhances oxidative stress in human endothelial cells …
- Flavan-3-ols having a γ-lactam from the roots of Actinidia arguta inhibit the formation of Advanced Glycation end products in vitro
- Transport of the Advanced Glycation end products alanylpyrraline and pyrralylalanine by the human proton-coupled peptide transporter hPEPT1
- … elevated in patients with stable coronary artery disease and is associated with serum levels of neopterin and the soluble receptor for Advanced Glycation end products
- Receptor for Advanced Glycation end products (RAGE) and its inflammatory ligand EN-RAGE in non-diabetic subjects with pre-mature coronary artery disease
- Restricted intake of dietary Advanced Glycation end products retards renal progression in the remnant kidney model
- Amyloid β interaction with receptor for Advanced Glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood …
- The inhibition of Advanced Glycation end-products-induced retinal vascular permeability by silver nanoparticles
- Advanced Glycation end products (AGEs)and cardiovascular disease (CVD) in diabetes
- Soluble receptor for Advanced Glycation end-products (sRAGE) and polymorphisms of RAGE and glyoxalase I genes in patients with pancreas cancer
- Serum levels of soluble form of receptor for Advanced Glycation end products (sRAGE) are correlated with AGEs in both diabetic and non-diabetic subjects
- Precursor of Advanced Glycation end products mediates ER-stress-induced caspase-3 activation of human dermal fibroblasts through NAD (P) H oxidase 4
- Pigment-epithelium-derived factor suppresses expression of receptor for Advanced Glycation end products in the eye of diabetic rats
- Receptor for Advanced Glycation end products (RAGE) is important in the prediction of recurrence in human oral squamous cell carcinoma
- Developmental expression of the receptor for Advanced Glycation end-products (RAGE) and its response to hyperoxia in the neonatal rat lung
- Skin-autofluorescence, a measure of tissue Advanced Glycation end-products (AGEs) , is related to diastolic function in dialysis patients
- … ribonuclear protein K and microRNA-16 in cyclooxygenase-2 RNA stability induced by S100b, a ligand of the receptor for Advanced Glycation end products
- Effect of long‐term orlistat treatment on serum levels of Advanced Glycation end‐products in women with polycystic ovary syndrome
- Possible link of food-derived Advanced Glycation end products (AGEs)to the development of diabetes
- Advanced Glycation end products subspecies-selectively induce adhesion molecule expression and cytokine production in human peripheral blood mononuclear cells
- Increased serum Advanced Glycation end products are associated with impairment in HDL antioxidative capacity in diabetic nephropathy
- Soluble receptor for Advanced Glycation end products in multiple sclerosis: a potential marker of disease severity
- Blockage of receptor for Advanced Glycation end products prevents development of cardiac dysfunction in db/db type 2 diabetic mice
- Advanced Glycation end products in pregnancies complicated with diabetes mellitus or preeclampsia
- Diagnostic utility of serum or cerebrospinal fluid levels of toxic Advanced Glycation end-products (TAGE) in early detection of Alzheimer’s disease
- Low levels of soluble receptor for Advanced Glycation end products in non-ST elevation myocardial infarction patients
- PPARγ-mediated Advanced Glycation end products regulation of neural stem cells
- Soluble receptor for Advanced Glycation end products (sRAGE) and endogenous secretory RAGE (esRAGE) in amniotic fluid: modulation by infection and …
- Advanced Glycation end products (AGEs)and their receptors (RAGEs) in diabetic vascular disease
- Advanced Glycation end products induce chemokine/cytokine production via activation of p38 pathway and inhibit proliferation and migration of bone marrow …
- Receptor for Advanced Glycation end-products (RAGE) regulation of adiposity and adiponectin is associated with atherogenesis in apoE-deficient mouse
- Advanced Glycation end products of DNA: Quantification of N2-(1-Carboxyethyl)-2′-deoxyguanosine in Biological Samples by Liquid Chromatography …
- Expression of the receptor for Advanced Glycation end products in oligodendrocytes in response to oxidative stress
- Expression of the receptor of Advanced Glycation end products in the gingival tissue of smokers with generalized periodontal disease and after nornicotine induction in …
- Advanced Glycation end products regulate extracellular matrix protein and protease expression by human glomerular mesangial cells
- Positive association of serum levels of Advanced Glycation end products and high mobility group box–1 with asymmetric dimethylarginine in nondiabetic chronic …
- A neutralizing antibody against receptor for Advanced Glycation end products (RAGE) reduces atherosclerosis in uremic mice
- Androgens associated with Advanced Glycation end-products in postmenopausal women
- Advanced Glycation and lipoxidation end products –amplifiers of inflammation: the role of food
- A novel role for the Receptor for Advanced Glycation End-products in neural progenitor cells derived from adult SubVentricular Zone
- Advanced Glycation end-products suppress neuropilin-1 expression in podocytes
- Combined immunoelectron microscopic and computer-assisted image analyses to detect Advanced Glycation end-products in human myocardium
- Olmesartan blocks Advanced Glycation end products (AGEs) -induced angiogenesis in vitro by suppressing receptor for AGEs (RAGE) expression
- Internalization of the receptor for Advanced Glycation end products (RAGE) is required to mediate intracellular responses
- The role of the receptor for Advanced Glycation end-products in a murine model of silicosis
- Advanced Glycation end products and the absence of premature atherosclerosis in glycogen storage disease Ia
- Serum level of Advanced Glycation end-products (AGEs)is an independent determinant of plasminogen activator inhibitor-1 (PAI-1) in nondiabetic general population
- Role of maltol in Advanced Glycation end products and free radicals: in‐vitro and in‐vivo studies
- Analysis of DNA-bound Advanced Glycation end-products by LC and mass spectrometry
- Expression of Advanced Glycation end products and their receptor in skin from patients with systemic sclerosis with and without calcinosis
- Angiotensin II receptor blocker inhibits abnormal accumulation of Advanced Glycation end products and retinal damage in a rat model of type 2 diabetes
- Analysis and biological relevance of Advanced Glycation end‐products of DNA in eukaryotic cells
- Cloning, characterisation, and comparative quantitative expression analyses of receptor for Advanced Glycation end products (RAGE) transcript forms
- Effect of taurine on Advanced Glycation end products -induced hypertrophy in renal tubular epithelial cells
- Inhibition of Advanced Glycation end products (AGEs) : An implicit goal in clinical medicine for the treatment of diabetic nephropathy?
- Induction of receptor for Advanced Glycation end products by EBV latent membrane protein 1 and its correlation with angiogenesis and cervical lymph node metastasis …
- Diabetic threesome (hyperglycaemia, renal function and nutrition) and Advanced Glycation end products : evidence for the multiple-hit agent?
- Detection of feto-maternal infection/inflammation by the soluble receptor for Advanced Glycation end products (sRAGE): results of a pilot study
- Hepatic expression of galectin-3 and receptor for Advanced Glycation end products in patients with liver disease
- Receptor for Advanced Glycation end products in donor lungs is associated with primary graft dysfunction after lung transplantation
- Serum amyloid A activates nuclear factor-kappaB in rheumatoid synovial fibroblasts through binding to receptor of Advanced Glycation end-products.
- … cardiac fibrosis in type 2 diabetic rats: the effect of rosiglitazone on myocardial expression of receptor for Advanced Glycation end products and of connective tissue …
- Immunohistochemical demonstration of Advanced Glycation end products and the effects of Advanced Glycation end products in ossified ligament tissues in vitro
- Constituents of the flowers of Platycodon grandiflorum with inhibitory activity on Advanced Glycation end products and rat lens aldose reductase in vitro
- Receptor for Advanced Glycation end products and neuronal deficit in the fatal brain edema of diabetic ketoacidosis
- Pigment epithelium-derived factor inhibits Advanced Glycation end products -induced retinal vascular permeability
- Plasma levels of soluble receptor for Advanced Glycation end products are associated with endothelial function and predict cardiovascular events in nondiabetic …
- Inhibitors of Aldose Reductase and Formation of Advanced Glycation End-Products in Moutan Cortex (Paeonia suffruticosa)
- Receptor for Advanced Glycation end products (RAGE) mediates neuronal differentiation and neurite outgrowth
- Ectodomain shedding of the receptor for Advanced Glycation end products : a novel therapeutic target for Alzheimer’s disease
- Expression of receptor for Advanced Glycation end products (RAGE) is related to prognosis in patients with esophageal squamous cell carcinoma
- Adverse effects of Advanced Glycation end products on embryonal development
- Fluorescent Advanced Glycation end products in the detection of factual stages of cartilage degeneration.
- Expression of senescence-associated β-galactosidase (SA-β-Gal) by human skin fibroblasts, effect of Advanced Glycation end-products and fucose or rhamnose-rich …
- Receptor for Advanced Glycation end products is upregulated in optic neuropathy of Alzheimer’s disease
- Levels of soluble receptor for Advanced Glycation end products in acute ischemic stroke without a source of cardioembolism
- Assaying soluble forms of receptor for Advanced Glycation end products
- C-reactive protein (CRP) up-regulates expression of receptor for Advanced Glycation end products (RAGE) and its inflammatory ligand EN-RAGE in THP-1 cells …
- Grape seed proanthocyanidin extracts inhibit vascular cell adhesion molecule expression induced by Advanced Glycation end products through activation of …
- Peroxyl radicals are essential reagents in the oxidation steps of the Maillard reaction leading to generation of Advanced Glycation end products
- Specific siRNA targeting the receptor for Advanced Glycation end products inhibits experimental hepatic fibrosis in rats
- … epithelium‐derived factor (PEDF) prevents platelet activation and aggregation in diabetic rats by blocking deleterious effects of Advanced Glycation end products …
- Inhibition of L-arginine metabolizing enzymes by L-arginine-derived Advanced Glycation end products
- Inhibitory effect of GSPE on RAGE expression induced by Advanced Glycation end products in endothelial cells
- Advanced Glycation end products ‐induced apoptosis attenuated by PPARδ activation and epigallocatechin gallate through NF‐κB pathway in human embryonic …
- Atorvastatin reduces proteinuria in non-diabetic chronic kidney disease patients partly via lowering serum levels of Advanced Glycation end products (AGEs)
- Effects of nitric oxide and antioxidants on Advanced Glycation end products -induced hypertrophic growth in human renal tubular cells
- Involvement of Na+/H+ exchanger 1 in Advanced Glycation end products -induced proliferation of vascular smooth muscle cell
- Circulating levels of Advanced Glycation end products (AGE) and interleukin-6 (IL-6) are independent determinants of serum asymmetric dimethylarginine (ADMA) …
- Expression of receptor for Advanced Glycation end products in sarcoid granulomas
- Receptors for Advanced Glycation end products and their physiological and clinical significance
- Blockade of renin-angiotensin system attenuates Advanced Glycation end products -mediated signaling pathways
- Endogenous secretory receptor for Advanced Glycation end-products and cardiovascular disease in end-stage renal disease
- Advanced Glycation end products and receptors in Fuchs’ dystrophy corneas undergoing Descemet’s stripping with endothelial keratoplasty
- Positive association of circulating levels of Advanced Glycation end products (AGEs)with pigment epithelium-derived factor (PEDF) in a general population
- Association of 1704G/T and G82S polymorphisms in the receptor for Advanced Glycation end products gene with diabetic retinopathy in Chinese population
- Advanced Glycation end‐products, anti‐hypertensive treatment and diastolic function in patients with hypertension and diastolic dysfunction
- Nifedipine inhibits Advanced Glycation end products (AGEs)and their receptor (RAGE) interaction-mediated proximal tubular cell injury via peroxisome proliferator …
- Glucagon-like peptide-1 counteracts the detrimental effects of Advanced Glycation End-Products in the pancreatic beta cell line HIT-T 15
- Hepatocyte growth factor prevents Advanced Glycation end products -induced injury and oxidative stress through a PI3K/Akt-dependent pathway in human endothelial …
- Flavonoid glycosides from the leaves of Uvaria rufa with Advanced Glycation end-products inhibitory activity
- PLC/CAMK IV–NF-κB involved in the receptor for Advanced Glycation end products mediated signaling pathway in human endothelial cells
- Sinomenine inhibits activation of rat retinal microglia induced by Advanced Glycation end products
- Low levels of plasma soluble receptor for Advanced Glycation end products are associated with severe leukoaraiosis in acute stroke patients
- C-reactive protein upregulates receptor for Advanced Glycation end products expression and alters antioxidant defenses in rat endothelial progenitor cells
- Advanced Glycation end‐products activate extracellular signal‐regulated kinase via the oxidative stress‐EGF receptor pathway in renal fibroblasts
- Advanced Glycation end products downregulates peroxisome proliferator-activated receptor γ expression in cultured rabbit chondrocyte through MAPK pathway
- Advanced Glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine/chemokine production in endothelial cells via activation of …
- Inhibitors of Advanced Glycation end‐products prevent loss of enteric neuronal nitric oxide synthase in diabetic rats
- Advanced Glycation end products increase transglutaminase activity in primary porcine tenocytes
- Serum levels of soluble form of receptor for Advanced Glycation end products (sRAGE) may reflect tissue RAGE expression in diabetes
- Investigation of pathways of Advanced Glycation end‐products accumulation in macrophages
- Evaluation of Advanced Glycation end-products in diabetic and inherited canine cataracts
- Pigment epithelium-derived factor (PEDF) prevents Advanced Glycation end products (AGEs) -elicited endothelial nitric oxide synthase (eNOS) reduction through its …
- Advanced Glycation end products enhance monocyte activation during human mixed lymphocyte reaction
- The HMG-CoA reductase inhibitor cerivastatin lowers Advanced Glycation end products in patients with type 2 diabetes
- Advanced Glycation end products Upregulate C‐reactive Protein Synthesis by Human Hepatocytes Through Stimulation of Monocyte IL‐6 and IL‐1β Production
- Concentrations of receptor for Advanced Glycation end products , VEGF and CML in plasma, follicular fluid, and peritoneal fluid in women with and without …
- Comparison of distinct protein isoforms of the receptor for Advanced Glycation end-products expressed in murine tissues and cell lines
- Accumulation of Advanced Glycation end (AGEs)products in intensive care patients: an observational, prospective study
- Serum leptin, but not adiponectin and receptor for Advanced Glycation end products , is able to distinguish autoimmune pancreatitis from both chronic pancreatitis and …
- Effect of protocatechualdehyde on receptor for Advanced Glycation end products and TGF-β1 expression in human lens epithelial cells cultured under diabetic …
- Possible involvement of tobacco-derived Advanced Glycation end products (AGEs)in an increased risk for developing cancers and cardiovascular disease in former …
- Genomic damage and malignancy in end-stage renal failure: do Advanced Glycation end products contribute?
- Endogenous secretory receptor for Advanced Glycation end products in non–small cell lung carcinoma
- Effects of glucose and Advanced Glycation end products on oxidative stress in MIN6 cells
- An α-glucosidase inhibitor, acarbose treatment decreases serum levels of glyceraldehyde-derived Advanced Glycation end products (AGEs)in patients with type 2 …
- Raman spectroscopy of Advanced Glycation end products (AGEs) , possible markers for progressive retinal dysfunction
- Microwave-assisted Maillard reactions for the preparation of Advanced Glycation end products (AGEs)
- Advanced Glycation end products and C-peptide—modulators in diabetic vasculopathy and atherogenesis
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