Premature senescence is considered as a cellular defense mechanism to prevent tumorigenesis. Although recent evidences show that c-Jun N-terminal kinase (JNK) is involved in the senescence process, the mechanism for this regulation is not fully understood. Here, we examined the role of JNK in premature senescence of tumor cells. Treatment of cells with the JNK-specific inhibitor SP600125 caused phenotypical changes of senescence and triggered a rapid increase in mitochondrial reactive oxygen species (ROS) production and DNA-damage response (DDR) in MCF7 breast carcinoma cells. ROS generation was attributed to the suppression of B-cell lymphoma-2 (Bcl-2) phosphorylation, and resulted in DNA damage and p53 activation. Bax did not change their localization to the mitochondria, which is required for apoptosis. The essential roles of JNK and phosphorylated Bcl-2 in preventing premature senescence were confirmed using RNA interference and ectopic expression of mutants of Bcl-2, including phosphomimetic and nonphosphorylatable forms. These findings were evidenced in H460 lung carcinoma cells and primary human embryonic fibroblasts. Altogether, our results showed that loss of JNK activity triggers a Bcl-2/ROS/DDR signaling cascade that ultimately leads to premature senescence, indicating that basal JNK activity is essential in preventing premature senescence.
ONCOGENE ACTIVATION
January 8, 2020MDM2
January 10, 2020Prevention of premature senescence requires JNK activation
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- Combinatorial Effect Of Statins And JNK Inhibitor On Proinflammatory Signaling In Human Abdominal Aortic Aneurysm Tissue
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- Cross-Inhibition Of JNK By P38 Visualized By Multiplexed Fluorescence Imaging
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- Curcumin, A Potential Inhibitor Of Up-Regulation Of Tnf-Alpha And Il-6 Induced By Palmitate In 3T3-L1 Adipocytes Through Nf-Kappab And JNK Pathway
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- Cyclic Amp-Guanine Exchange Factor Activation Inhibits JNK-Dependent Lipopolysaccharide-Induced Apoptosis In Rat Hepatocytes
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- D2/D3 Receptor Agonist Ropinirole Protects Dopaminergic Cell Line Against Rotenone‐Induced Apoptosis Through Inhibition Of Caspase‐And JNK‐Dependent Pathways
- Dab2 Inhibits The Cholesterol-Dependent Activation Of JNK By Tgf-Β
- Deprenyl, A Therapeutic Agent For Parkinson’S Disease, Inhibits Arsenic Toxicity Potentiated By Gsh Depletion Via Inhibition Of JNK Activation
- Design And Characterization Of A Potent And Selective Dual Atp-And Substrate-Competitive Subnanomolar Bidentate C-Jun N-Terminal Kinase (JNK) Inhibitor
- Design And Synthesis Of A Novel, Orally Active, Brain Penetrant, Tri-Substituted Thiophene Based JNK Inhibitor
- Determination Of Tissue Levels Of A Neuroprotectant Drug: The Cell Permeable JNK Inhibitor Peptide
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- Diphlorethohydroxycarmalol Suppresses Ultraviolet B-Induced Matrix Metalloproteinases Via Inhibition Of JNK And Erk Signaling In Human Keratinocytes
- Discovery Of Cc-930, An Orally Active Anti-Fibrotic JNK Inhibitor
- Distinct Contributions Of JNK And P38 To Chromium Cytotoxicity And Inhibition Of Murine Embryonic Stem Cell Differentiation
- Divergent JNK Phosphorylation Of Hdac3 In Triple-Negative Breast Cancer Cells Determines Hdac Inhibitor Binding And Selectivity
- Dose-Dependent Neuroprotective Effect Of The JNK Inhibitor Brimapitide In 5Xfad Transgenic Mice
- Downregulation Of Ras C-Terminal Processing By JNK Inhibition
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- Effect Of C-Jun Nh2-Terminal Kinase (JNK) Inhibitor Sp600125 On Experimental Silicosis In Mice
- Effect Of Donor JNK Signal Transduction Inhibition On Transplant Outcome In Brain Dead Rat Model
- Effect Of JNK Inhibitor During Islet Isolation And Transplantation
- Effect Of JNK Inhibitor In A Rat Model Of Renal Ischemia-Reperfusion Injury
- Effect Of JNK Inhibitor Sp600125 On Hair Cell Regeneration In Zebrafish (Danio Rerio) Larvae
- Effects Of JNK Inhibitor On Inflammation And Fibrosis In The Ovary Tissue Of A Rat Model Of Polycystic Ovary Syndrome
- Effects Of JNK Inhibitor On Puromycin Aminonucleoside-Induced Nephropathy In Rats
- Effects Of The JNK Inhibitor Anthra[1,9-Cd]Pyrazol-6(2H)-
One (Sp-600125) On Soluble Guanylyl Cyclase Α1 Gene Regulation And Cgmp Synthesis - Effects Of Uva On Tnf‐Α, Il‐1Β, And Il‐10 Expression Levels In Human Keratinocytes And Intervention Studies With An Antioxidant And A JNK Inhibitor
- Eliminating Acute Myeloid Leukemia Stem Cells By Targetingthe Niche Microenviromnent: Co-Inhibition Of Tnf/Il1-JNK And Nf-Κb
- Encephalopathy And Mechanisms Of Their Development
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- Erythromycin Restores Corticosteroid Sensitivity Induced By Cse Through Inhibition Of JNK/C-Jun Pathway
- Erythromycin Reverses Cigarette Smoke Extract-Induced Corticosteroid Insensitivity By Inhibition Of The JNK/C-Jun Pathway
- Estradiol Protects The Cochlea Against Gentamicin Ototoxicity Through Inhibition Of The JNK Pathway
- Estrogen Inhibits Starvation‐Induced Apoptosis In Osteocytes By A Redox‐Independent Process Involving Association Of JNK And Glutathione S‐Transferase P1‐1
- Evaluation Of Insl3 In Diabetic Testicular Tissue By Admministered JNK Inhibition
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- Excitotoxicity‐Induced Endocytosis Mediates Neuroprotection By Tat‐Peptide‐Linked JNK Inhibitor
- Exposure To The JNK Inhibitor Sp600125 (Anthrapyrazolone) During Early Zebrafish Development Results In Morphological Defects
- Fluid Shear Stress Inhibits Tnf-Α Activation Of JNK But Not Erk1/2 Or P38 In Human Umbilical Vein Endothelial Cells: Inhibitory Crosstalk Among Mapk Family Members
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- Functional P38 Mapk Identified By Biomarker Profiling Of Pancreatic Cancer Restrains Growth Through JNK Inhibition And Correlates With Improved Survival
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- Inhibition Of Cytokine-Mediated JNK Signalling By Purinergic P2Y11 Receptors, A Novel Protective Mechanism In Endothelial Cells
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- Inhibition Of JNK And P38 Mapk Phosphorylation By 5-(Acetylamino)-4-Oxo-6-
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- Inhibition Of JNK Sensitizes Hypoxic Colon Cancer Cells To Dna-Damaging Agents
- Inhibition Of JNK Signaling In The Asian Malaria Vector Anopheles Stephensi Extends Mosquito Longevity And Improves Resistance To Plasmodium Falciparum …
- Inhibition Of JNK Signalling Mediates Pparα‐Dependent Protection Against Intrahepatic Cholestasis By Fenofibrate
- Inhibition Of JNK Suppresses Autophagy And Attenuates Insulin Resistance In A Rat Model Of Nonalcoholic Fatty Liver Disease
- Inhibition Of JNK2 And JNK3 By JNK Inhibitor Ix Induces Prometaphase Arrest-Dependent Apoptotic Cell Death In Human Jurkat T Cells
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- Inhibition Of Phosphorylation Of JNK Suppresses Aβ-Induced Er Stress And Upregulates Prosurvival Mitochondrial Proteins In Rat Hippocampus
- Inhibition Of Pi3-Kinase Sensitises Hl60 Human Leukaemia Cells To Both Chemotherapeutic Drug-And Fas-Induced Apoptosis By A JNK Independent Pathway
- Inhibition Of Spinal C-Jun-Nh2-Terminal Kinase (JNK) Improves Locomotor Activity Of Spinal Cord Injured Rats
- Inhibition Of The C-Jun N-Terminal Kinase (JNK) Signaling Pathway By Curcumin
- Inhibition Of The JNK Signaling Pathway Increases Sensitivity Of Hepatocellular Carcinoma Cells To Cisplatin By Down-Regulating Expression Of P-Glycoprotein
- Inhibition Of The JNK Signalling Pathway Enhances Proteasome Inhibitor‐Induced Apoptosis Of Kidney Cancer Cells By Suppression Of Bag3 Expression
- Inhibition Of The JNK/Ap-1 Pathway Reduces Neuronal Death And Improves Behavioral Outcome After Neonatal Hypoxic–Ischemic Brain Injury
- Inhibition Of The JNK/Bim Pathway By Hsp70 Prevents Bax Activation In Uv‐Induced Apoptosis
- Inhibitor Of Nicotinamide Phosphoribosyltransferase Sensitizes Glioblastoma Cells To Temozolomide Via Activating Ros/JNK Signaling Pathway
- Intraperitoneal Injection Of JNK-Specific Inhibitor Sp600125 Inhibits The Expression Of Presenilin-1 And Notch Signaling In Mouse Brain Without Induction Of Apoptosis
- Investigating Tnf Inhibition Of Igf-1 Signalling Via JNK In Cell Culture Models Of Skeletal Muscle Atrophy
- Investigation Of Hdac Inhibition On Bovine Mammary Cell Inflammation Via Phosphate-Dependent Regulation Of JNK Signaling
- Isoliquiritigenin Inhibits JNK/Ap-1 Signaling In Du145 Human Prostate Cancer Cells
- Isoliquiritigenin Inhibits Migration And Invasion Of Prostate Cancer Cells: Possible Mediation By Decreased JNK/Ap-1 Signaling
- JNK Inactivation Suppresses Osteogenic Differentiation, But Robustly Induces Osteopontin Expression In Osteoblasts Through The Induction Of Inhibitor Of Dna Binding 4 …
- JNK Inhibition And Inflammation After Cerebral Ischemia
- JNK Inhibition Arrests Cotranslational Degradation
- JNK Inhibition As A Potential Strategy In Treating Parkinson’S Disease.
- JNK Inhibition Blocks Piperlongumine-Induced Cell Death And Transcriptional Activation Of Heme Oxygenase-1 In Pancreatic Cancer Cells
- JNK Inhibition By Glucocorticoids Prevents The Maturation Of Dendritic Cells Induced By Toll-Like Receptor 7 And Toll-Like Receptor 8
- JNK Inhibition By Sp600125 Attenuates Trans-10, Cis-12 Conjugated Linoleic Acid-Mediated Regulation Of Inflammatory And Lipogenic Gene Expression
- JNK Inhibition By Transforming Growth Factor-Β Type I Receptor (Tgf-Β Ri) In T Cells
- JNK Inhibition Improves Obesity-Induced Endothelial Dysfunction And Oxidative Stress Mimicking The Beneficial Effects Of Roux-En …
- JNK Inhibition Inhibits Lateral Line Neuromast Hair Cell Development
- JNK Inhibition Mimics The Beneficial Effect Of Roux-En-Y Gastric Bypass Surgery On Obesity-Induced Endothelial Dysfunction
- JNK Inhibition Of Vmat2 Contributes To Rotenone-Induced Oxidative Stress And Dopamine Neuron Death
- JNK Inhibition Protects Dopamine Neurons And Provides Behavioral Improvement In A Rat 6-Hydroxydopamine Model Of Parkinson’S Disease
- JNK Inhibition Reduced Retinal Ganglion Cell Death After Ischemia/Reperfusion In Vivo And After Hypoxia In Vitro
- JNK Inhibition Reduces Apoptosis And Neovascularization In A Murine Model Of Age-Related Macular Degeneration
- JNK Inhibition Reduces Lung Remodeling And Pulmonary Fibrotic Systemic Markers
- JNK Inhibition Restores Endothelial Function In Type 2 Diabetes Mellitus
- JNK Inhibition Sensitises Hepatocellular Carcinoma Cells But Not Normal Hepatocytes To The Tnf-Related Apoptosis-Inducing Ligand
- JNK Inhibition Sensitizes Tumor Cells To Radiation-Induced Premature Senescence Via Bcl-2/Ros/Ddr Signaling Pathway
- JNK Inhibitor Alleviates Apoptosis Of Fetal Neural Stem Cells Induced By Emulsified Isoflurane
- JNK Inhibitor Cc-930 Reduces Fibrosis In A Murine Model Of Nf1-Deficient Fracture Repair
- JNK Inhibitor D-JNKi Promotes Myelination In A Rat Model Of Diffuse White Matter Injury
- JNK Inhibitor Protects Dopaminergic Neurons By Reducing Cox-2 Expression In The Mptp Mouse Model Of Subacute Parkinson’S Disease
- JNK Inhibitor Sp600125 Attenuates Paraquat-Induced Acute Lung Injury: An In Vivo And In Vitro Study
- JNK Inhibitor Sp600125 Attenuates Trans-10, Cis-12 (10, 12) Conjugated Linoleic Acid (Cla)-Mediated Inflammation And Suppression Of Adipogenic And Lipogenic …
- JNK Inhibitor Sp600125 Decreased Lipid Peroxidation In Isolated Hepatocytes
- JNK Inhibitor Sp600125 Enhances Tgf‑Β‑Induced Apoptosis Of Rbe Human Cholangiocarcinoma Cells In A Smad‑Dependent Manner
- JNK Inhibitor Sp600125 Is A Partial Agonist Of Human Aryl Hydrocarbon Receptor And Induces Cyp1A1 And Cyp1A2 Genes In Primary Human Hepatocytes
- JNK Inhibitor Sp600125 Promotes The Formation Of Polymerized Tubulin, Leading To G2/M Phase Arrest, Endoreduplication, And Delayed Apoptosis
- JNK Inhibitor Sp600125 Protects Against Lipopolysaccharide‑Induced Acute Lung Injury Via Upregulation Of Claudin‑4
- JNK Inhibitor Sp600125 Reduces Cox-2 Expression By Attenuating Mrna In Activated Murine J774 Macrophages
- JNK Is Constitutively Active In Mantle Cell Lymphoma: Cell Cycle Deregulation And Polyploidy By JNK Inhibitor Sp600125
- JNK Pathway Inhibition Enhances Chemotherapeutic Sensitivity To Adriamycin In Nasopharyngeal Carcinoma Cells
- JNK Pathway Inhibition Selectively Primes Pancreatic Cancer Stem Cells To Trail-Induced Apoptosis Without Affecting The Physiology Of Normal Tissue Resident …
- JNK-In-8, A C-Jun N-Terminal Kinase Inhibitor, Improves Functional Recovery Through Suppressing Neuroinflammation In Ischemic Stroke
- JNK‐In‐8, Ac‐Jun N‐Terminal Kinase Inhibitor, Improves Functional Recovery Through Suppressing Neuroinflammation In Ischemic Stroke
- Joint Inhibition Of Tor And JNK Pathways Interacts To Extend The Lifespan Of Brachionus Manjavacas (Rotifera)
- Late Breaking Abstract-Evaluation Of The JNK Inhibitor, Cc-90001, In A Phase 1B Pulmonary Fibrosis Trial
- Leflunomide Or A77 1726 Protect From Acetaminophen-Induced Cell Injury Through Inhibition Of JNK-Mediated Mitochondrial Permeability Transition In Immortalized …
- Leishmania Mexicana Promastigotes Down Regulate JNK And P-38 Mapk Activation: Role In The Inhibition Of Camptothecin-Induced Apoptosis Of Monocyte-Derived …
- Leukotriene B4 Receptor Inhibitor Ly293111 Induces Cell Cycle Arrest And Apoptosis In Human Anaplastic Large-Cell Lymphoma Cells Via JNK Phosphorylation
- Lipoteichoic Acid Upregulates Plasminogen Activator Inhibitor-1 Expression In Human Pleural Mesothelial Cells Via Tlr2/JNK/Ap-1 Pathway
- Local Inhibition Of Prc2 Activity By H3. 3K27M Drives Dna Replication Defects Through Misregulation Of The JNK Pathway
- Low-Power Laser Irradiation Inhibits Apoptosis Induced By Abeta Via Preventing Ask-1/JNK Pathway
- Lycium Barbarum (Wolfberry) Reduces Secondary Degeneration And Oxidative Stress, And Inhibits JNK Pathway In Retina After Partial Optic Nerve Transection
- Map Kinase Phosphatase 1 (Mkp-1/Dusp1) Is Neuroprotective In Huntington’S Disease Via Additive Effects Of JNK And P38 Inhibition
- Mapk Inhibitors, Particularly The JNK Inhibitor, Increase Cell Death Effects In H2O2-Treated Lung Cancer Cells Via Increased Superoxide Anion And Glutathione …
- Mcl-1 Degradation Mediated By JNK Activation Via Mekk1/Tak1-Mkk4 Contributes To Anticancer Activity Of New Tubulin Inhibitor Mt189
- Mechanistic Studies Of The Dual Akt And JNK Inhibitor Chaetoglobosin K: Effect On Downstream Pathways And Ap-1 Proteins In Tumorigenic Cells
- Metabolism And Disposition Of A Potent And Selective JNK Inhibitor [14C]Tanzisertib Following Oral Administration To Rats, Dogs And Humans
- Metformin Protects Against Intestinal Barrier Dysfunction Via Ampkα1‐Dependent Inhibition Of JNK Signalling Activation
- Metformin Protects H9C2 Cardiomyocytes From High-Glucose And Hypoxia/Reoxygenation Injury Via Inhibition Of Reactive Oxygen Species Generation And Inflammatory …
- Mitochondrial Protection By The JNK Inhibitor Leflunomide Rescues Mice From Acetaminophen‐Induced Liver Injury
- Mkp2 Inhibits Tgf-Β1-Induced Epithelial-To-Mesenchymal Transition In Renal Tubular Epithelial Cells Through A JNK-Dependent Pathway
- Mkp2 Suppresses Tgf-Β1-Induced Epithelial-To-Mesenchymal Transition Through JNK Inhibition
- Modulation Of Amyloid-Β Peptide-Induced Toxicity Through Inhibition Of JNK Nuclear Localization And Caspase-2 Activation
- Mtorc1 But Not JNK Inhibition Augments Glucocorticosteroid Efficacy In Multiple Sclerosis (S55. 004)
- Murf1 Inhibits JNK Signaling In Cardiac Ischemia Reperfusion Injury By Degrading Phosphorylated Cjun
- Myc Inhibits JNK-Mediated Cell Death In Vivo
- Neuroprotection Against Ischemic Brain Injury By A Small Peptide Inhibitor Of C-Jun N-Terminal Kinase (JNK) Via Nuclear And Non-Nuclear Pathways
- New Microtubulin Inhibitor Mt189 Suppresses Angiogenesis Via The JNK-Vegf/Vegfr2 Signaling Axis
- Nicotinamide Mononucleotide Inhibits JNK Activation To Reverse Alzheimer Disease
- Nmt1 Inhibition Modulates Breast Cancer Progression Through Stress-Triggered JNK Pathway
- Nuclear Hormone Receptor Antagonism With Ap-1 By Inhibition Of The JNK Pathway
- Oxidative Stress Resistance Through Blocking Hsp60 Translocation Followed By Sapk/JNK Inhibition In Aged Human Diploid Fibroblasts
- P38 Mapk Activation, JNK Inhibition, Neoplastic Growth Inhibition, And Increased Gap Junction Communication In Human Lung Carcinoma And Ras‐Transformed Cells By …
- P38Α Mapk Inhibits JNK Activation And Collaborates With Iκb Kinase 2 To Prevent Endotoxin‐Induced Liver Failure
- P38Α Mapk Inhibits Stretch-Induced JNK Activation In Cardiac Myocytes Through Mkp-1
- Paeoniflorin Inhibits Tributyltin Chloride-Induced Apoptosis In Hypothalamic Neurons Via Inhibition Of Mkk4-JNK Signaling Pathway
- Pd08-03: Inhibition Of Mek/Erk-And JNK-Dependent Expression Of Interleukin-6 And Interleukin-8 Targets Basal-Like Breast Cancer Stem Cells.
- Pharmacological C-Jun Nh2-Terminal Kinase (JNK) Pathway Inhibition Reduces Severity Of Spinal Muscular Atrophy Disease In Mice.
- Pi3K P110Β Isoform Synergizes With JNK In The Regulation Of Glioblastoma Cell Proliferation And Migration Through Akt And Fak Inhibition
- Pinch-1 Promotes Bcl-2-Dependent Survival Signalling And Inhibits JNK-Mediated Apoptosis In The Primitive Endoderm
- Plasminogen Activator Inhibitor-1 Potentiates Lps-Induced Neutrophil Activation Through A JNK–Mediated Pathway
- Posttranslational Modification Of Vesicular Stomatitis Virus Glycoprotein, But Not JNK Inhibition, Is The Antiviral Mechanism Of Sp600125
- Potentiation Of Oxaliplatin In Colon Cancer By JNK Inhibition
- Primary Resistance To Egfr Inhibition In Glioblastoma Is Mediated By A Tnf-JNK-Axl-Erk Signaling Axis
- Prolactin Protects Against Cytokine-Induced Beta-Cell Death By Nfκb And JNK Inhibition
- Proteasome Inhibitor Ps‐341 Induces Growth Arrest And Apoptosis Of Non‐Small Cell Lung Cancer Cells Via The JNK/C‐Jun/Ap‐1 Signaling
- Proteasome Inhibitors Potentiate Leukemic Cell Apoptosis Induced By The Cyclin-Dependent Kinase Inhibitor Flavopiridol Through A Sapk/JNK– And Nf-Κb …
- Protection From Diclofenac-Induced Small Intestinal Injury By The JNK Inhibitor Sp600125 In A Mouse Model Of Nsaid-Associated Enteropathy
- Protective Effect Of A JNK Inhibitor Against Retinal Ganglion Cell Loss Induced By Acute Moderate Ocular Hypertension
- Protective Effects Of JNK Inhibition In Retinal Ganglion Cells And In Retinal Ischemia/Reperfusion Injury
- Protective Effects Of JNK Inhibitor On Cultured Adult Rat Retinal Ganglion Cells
- Protective Role Of JNK Inhibitor Sp600125 In Sepsis-Induced Acute Lung Injury
- Protective Role Of Taurine Against Arsenic-Induced Mitochondria-Dependent Hepatic Apoptosis Via The Inhibition Of Pkcδ-JNK Pathway
- Proteinase-Activated Receptor-2 Mediated Inhibition Of Tnfα-Stimulated JNK Activation—A Novel Paradigm For Gq/11 Linked Gpcrs
- Quantitative Proteomic Analysis Reveals Maturation As A Mechanism Underlying Glucocorticoid Resistance In B Lineage All And Re‐Sensitization By JNK Inhibition
- Rapamycin Potentiates Dexamethasone-Induced Apoptosis And Inhibits JNK Activity In Lymphoblastoid Cells
- Recovery Of Articular Cartilage Metabolism Following Thermal Stress Is Facilitated By Igf-1 And JNK Inhibitor
- Reduction Of Autophagy Markers Mediated Protective Effects Of JNK Inhibitor And Bucladesine On Memory Deficit Induced By Aβ In Rats
- Regulation Of Gene Expression By The Amyloid Precursor Protein: Inhibition Of The JNK/C-Jun Pathway
- Regulation Of Lipopolysaccharide-Induced Lung Inflammation By Plasminogen Activator Inhibitor-1 Through A JNK-Mediated Pathway
- Regulation Of Trehalase Expression Inhibits Apoptosis In Diapause Cardioprotective 3′, 4′-Dihydroxyflavonol Attenuation Of JNK And P38Mapk Signalling Involves …
- Rescuing Melanoma Epitope-Specific Cytolytic T Lymphocytes From Activation-Induced Cell Death, By Sp600125, An Inhibitor Of JNK: Implications In Cancer …
- Resveratrol Confers Cardioprotection Against Ischemia/Reperfusion Injury By Inhibition Of JNK Via Ampk
- Role Of JNK Translocation To Mitochondria Leading To Inhibition Of Mitochondria Bioenergetics In Acetaminophen-Induced Liver Injury
- Role Of JNK/Atf-2 Pathway In Inhibition Of Thrombospondin-1 (Tsp-1) Expression And Apoptosis Mediated By Doxorubicin And Camptothecin In Ftc-133 Cells
- Ros-Dependent Activation Of JNK Converts P53 Into An Efficient Inhibitor Of Oncogenes Leading To Robust Apoptosis
- Rosiglitazone Reduces Tau Phosphorylation Via JNK Inhibition In The Hippocampus Of Rats With Type 2 Diabetes And Tau Transfected Sh-Sy5Y Cells
- Rubus Coreanus Inhibits Oxidized-Ldl Uptake By Macrophages Through Regulation Of JNK Activation
- Sb203580, A Pharmacological Inhibitor Of P38 Map Kinase Transduction Pathway Activates Erk And JNK Map Kinases In Primary Cultures Of Human Hepatocytes
- Selective Inhibition Of JNK With A Peptide Inhibitor Attenuates Pain Hypersensitivity And Tumor Growth In A Mouse Skin Cancer Pain Model
- Selective Inhibition Of Mitochondrial JNK Signaling Achieved Using Peptide Mimicry Of The Sab Kinase Interacting Motif-1 (Kim1)
- Selenite Inhibits The C-Jun N-Terminal Kinase/Stress-Activated Protein Kinase (JNK/Sapk) Through A Thiol Redox Mechanism
- Sesquiterpene Dimer (Dsf-52) From Artemisia Argyi Inhibits Microglia-Mediated Neuroinflammation Via Suppression Of Nf-Κb, JNK/P38 Mapks And Jak2/Stat3 …
- Shear Stress Inhibition Of H2O2 Induced P66Shc Phosphorylation By Ask1–JNK Inactivation In Endothelium
- Silencing Glycogen Synthase Kinase-3Β Inhibits Acetaminophen Hepatotoxicity And Attenuates JNK Activation And Loss Of Glutamate Cysteine Ligase And Myeloid Cell …
- Silencing Sox2 Expression By Rna Interference Inhibits Proliferation, Invasion And Metastasis, And Induces Apoptosis Through Map4K4/JNK Signaling Pathway In …
- Sirtuin 3 Inhibition Induces Mitochondrial Stress In Tongue Cancer By Targeting Mitochondrial Fission And The JNK-Fis1 Biological Axis
- Smad4 Inhibits Cell Migration Via Suppression Of JNK Activity In Human Pancreatic Carcinoma Panc‑1 Cells
- Small Peptide Inhibitor Of JNKs Protects Against Mptp-Induced Nigral Dopaminergic Injury Via Inhibiting The JNK-Signaling Pathway
- Snp-Induced Apoptosis May Be Mediated With Caspase Inhibitor By JNK Signaling Pathways In Rabbit Articular Chondrocytes
- Sorafenib Suppresses JNK-Dependent Apoptosis Through Inhibition Of Zak
- Sp600125 Suppresses Cdk1 And Induces Endoreplication Directly From G2 Phase, Independent Of JNK Inhibition
- Sp600125, A Competitive Inhibitor Of JNK Attenuates Streptozotocin Induced Neurocognitive Deficit And Oxidative Stress In Rats
- Sp600125, A JNK Inhibitor, Suppresses Growth Of JNK-Inactive Glioblastoma Cells Through Cell-Cycle G2/M Phase Arrest
- Sp600125, A New JNK Inhibitor, Protects Dopaminergic Neurons In The Mptp Model Of Parkinson’S Disease
- Sp600125, A Selective JNK Inhibitor, Aggravates Hepatic Ischemia-Reperfusion Injury
- Sp600125, A Selective JNK Inhibitor, Protects Ischemic Renal Injury Via Suppressing The Extrinsic Pathways Of Apoptosis
- Specific Inhibition Of The JNK Pathway Promotes Locomotor Recovery And Neuroprotection After Mouse Spinal Cord Injury
- Specific JNK Inhibition By D-JNKi1 Protects Purkinje Cells From Cell Death In Lurcher Mutant Mouse
- Stimulation Of Insulin Signaling And Inhibition Of JNK-Ap1 Activation Protect Cells From Amyloid-Β-Induced Signaling Dysregulation And Inflammatory Response
- Stressor-Like Effects Of C-Jun N-Terminal Kinase (JNK) Inhibition
- Structural And Biological Evaluation Of Halogen Derivatives Of 1, 9-Pyrazoloanthrones Towards The Design Of A Specific Potent Inhibitor Of C-Jun-N-Terminal Kinase (JNK)
- Subconjunctival Injection Of Xg-102, A JNK Inhibitor Peptide, In Patients With Intraocular Inflammation: A Safety And Tolerability Study
- Sulfatase 2 Protects Hepatocellular Carcinoma Cells Against Apoptosis Induced By The Pi3K Inhibitor Ly294002 And Erk And JNK Kinase Inhibitors
- Suppression Of Hiv-1 Viral Replication And Cellular Pathogenesis By A Novel P38/JNK Kinase Inhibitor
- Suppression Of Stress Kinase JNK Is Involved In Hsp72-Mediated Protection Of Myogenic Cells From Transient Energy Deprivation Hsp72 Alleviates The Stress-Induced …
- Synergistic Effect Of Pi3Kδ Inhibitor Cal-101 And JNK Inhibitor Sp600125 On Glioblastoma Cell Proliferation
- Synergistic Inhibition Of Erk1/2 And JNK, Not P38, Phosphorylation Ameliorates Neuronal Damages After Traumatic Brain Injury
- Targeted Inhibition Of The Dual Specificity Phosphatases Dusp1 And Dusp6 Suppress Mpnst Growth Via JNK
- Targeting Ciks Expression Or Ciks/Il-17Ra Interaction Inhibits Il-17A-Induced Cardiomyocyte Death By Reversing JNK Activation And Dusp1/Mkp-1 Inhibition
- Targeting Muc 1 And JNK By Rna Interference And Inhibitor Inhibit The Development Of Hepatocellular Carcinoma
- Targeting The JNK Mapk Cascade For Inhibition: Basic Science And Therapeutic Potential
- Taz Inhibition Promotes Il-2-Induced Apoptosis Of Hepatocellular Carcinoma Cells By Activating The JNK/F-Actin/Mitochondrial Fission Pathway
- The Bradykinin-Cgmp-Pkg Pathway Augments Insulin Sensitivity Via Upregulation Of Mapk Phosphatase-5 And Inhibition Of JNK
- The C‐Jun N‐Terminal Kinase (JNK) Inhibitor Xg‐102 Enhances The Neuroprotection Of Hyperbaric Oxygen After Cerebral Ischaemia In Adult Rats
- The Combination Of Silencing Bag3 And Inhibition Of The JNK Pathway Enhances Hyperthermia Sensitivity In Human Oral Squamous Cell Carcinoma Cells
- The Covalent JNK Inhibitor, JNK-In-8, Synergizes With Lapatinib To Cause Cell Death In Basal-Like Breast Cancer Cell Lines
- The Critical Features And The Mechanism Of Inhibition Of A Kinase Interaction Motif-Based Peptide Inhibitor Of JNK
- The Effect Of The JNK Inhibitor, Jip Peptide, On Human T Lymphocyte Proliferation And Cytokine Production
- The Effects Of Short-Term JNK Inhibition On The Survival And Growth Of Aged Sympathetic Neurons
- The Ephb6 Receptor Inhibits JNK Activation In T Lymphocytes And Modulates T Cell Receptor-Mediated Responses
- The Impact Of JNK Inhibitor D-JNKi-1 In A Murine Model Of Chronic Colitis Induced By Dextran Sulfate Sodium
- The Influence Of JNK And P38 Mapk Inhibition On Il-12P40 And Il-23 Production Depending On Il12B Promoter Polymorphism
- The Influence Of JNK Inhibitor On Hemodynamics After Ischemia/Reperfusion Injury To The Heart In Rats
- The JNK Binding Domain Of Islet-Brain 1 Inhibits Il-1 Induced JNK Activity And Apoptosis But Not The Transcription Of Key Proapoptotic Or Protective Genes In Insulin …
- The JNK Inhibitor D-JNKi-1 Blocks Apoptotic JNK Signaling In Brain Mitochondria
- The JNK Inhibitor Sp600125 Enhances Dihydroartemisinin‐Induced Apoptosis By Accelerating Bax Translocation Into Mitochondria In Human Lung Adenocarcinoma …
- The JNK Inhibitor Sp600129 Enhances Apoptosis Of Hcc Cells Induced By The Tumor Suppressor Wwox
- The JNK Inhibitor Xg-102 Protects Against Tnbs-Induced Colitis
- The JNK Inhibitor Xg-102 Protects From Ischemic Damage With Delayed Intravenous Administration Also In The Presence Of Recombinant Tissue Plasminogen Activator
- The Mkk7 Inhibitor Peptide Gadd45Β-I Attenuates Er Stress-Induced Mitochondrial Dysfunction In Ht22 Cells: Involvement Of JNK-Wnt Pathway
- The N-Cor-Hdac3 Nuclear Receptor Corepressor Complex Inhibits The JNK Pathway Through The Integral Subunit Gps2
- The Nedd8-Activating Enzyme Inhibitor, Mln4924, Cooperates With Trail To Augment Apoptosis Through JNK-Dependent Downregulation Of C-Flip In Head And Neck …
- The Neuroprotective Actions Of Fk506 Binding Protein Ligands: Neuronal Survival Is Triggered By De Novo Rna Synthesis, But Is Independent Of Inhibition Of JNK And …
- The Novel Akt Inhibitor, Perifosine, Induces Caspase-Dependent Apoptosis And Downregulates P-Glycoprotein Expression In Multidrug-Resistant Human T-Acute …
- The Novel JNK Inhibitor As602801 Inhibits Cancer Stem Cells In Vitro And In Vivo
- The Proteasome Inhibitor Bortezomib Enhances Atra-Induced Differentiation Of Neuroblastoma Cells Via The JNK Mitogen-Activated Protein Kinase Pathway
- The Protectiveeffects Of JNK Inhibitor On Β-Amyloid-Induced Neuronal Apoptotic Factors And Spatial Memory Behavior, Using …
- The Protein Kinase C Inhibitor, Ro-31-7459, Is A Potent Activator Of Erk And JNK Map Kinases In Huvecs And Yet Inhibits Cyclic Amp-Stimulated Socs-3 …
- The Reverse-Mode Ncx1 Activity Inhibitor Kb-R7943 Promotes Prostate Cancer Cell Death By Activating The JNK Pathway And Blocking Autophagic Flux
- The Sequential Combination Of A JNK Inhibitor And Simvastatin Protects Porcine Islets From Peritransplant Apoptosis And Inflammation
- The Specific JNK Inhibitor Sp600125 Targets Tumour Necrosis Factor‐Α Production And Epithelial Cell Apoptosis In Acute Murine Colitis
- The Specific, Reversible JNK Inhibitor Sp600125 Improves Survivability And Attenuates Neuronal Cell Death In Experimental Cerebral Malaria (Ecm)
- The Synergistic Repressive Effect Of Nf-Κb And JNK Inhibitor On The Clonogenic Capacity Of Jurkat Leukemia Cells
- The Tat-JNK Inhibitor Peptide Interferes With Beta Amyloid Protein Stability
- Time-Staggered Inhibition Of JNK Effectively Sensitizes Chemoresistant Ovarian Cancer Cells To Cisplatin And Paclitaxel
- Tissue Inhibitor Of Metalloproteinase-3 Inhibits Neonatal Mouse Cardiomyocyte Proliferation Via Egfr/JNK/Sp-1 Signaling
- Tnfalpha Reduces Glucocorticoid-Dependent Transcription: Rescue By Long-Acting Beta2-Adrenceptor Agonists And JNK Inhibition
- Tnf-Α Up-Regulates Cellular Inhibitor Of Apoptosis Protein 2 (C-Iap2) Via C-Jun N-Terminal Kinase (JNK) Pathway In Nasopharyngeal Carcinoma
- Trail-Resistance In Pancreatic Cancer Stem Cells Can Be Regulated Through JNK Pathway Inhibition Without Impacting Resident Stem Cell Physiology
- Transferred Tumor Suppressor Blu Inhibits Proliferation Of Nasopharyngeal Carcinoma Cells By Regulation Of Cell Cycle, JNK And Cyclin D1 Promoters
- Treatment With A JNK Inhibitor Increases, Whereas Treatment With A P38 Inhibitor Decreases, H2O2-Induced Calf Pulmonary Arterial Endothelial Cell Death
- Triptolide Inhibits Cox‐2 Expression And Pge2 Release By Suppressing The Activity Of Nf‐Κb And JNK In Lps‐Treated Microglia
- Urotensin Ii Inhibitor Eases Neuropathic Pain By Suppressing The JNK/Nf-Κb Pathway
- Ursolic Acid Induces Pc‐3 Cell Apoptosis Via Activation Of JNK And Inhibition Of Akt Pathways In Vitro
- Use Of Saikosaponin D And JNK Inhibitor Sp600125, Alone Or In Combination, Inhibits Malignant Properties Of Human Osteosarcoma U2 Cells
- Yes-Associated Protein Reduces Neuroinflammation Through Upregulation Of Sirt3 And Inhibition Of JNK Signaling Pathway