Exercise prevents diet-induced cellular senescence in adipose tissue
Physiological aging: links among adipose tissue dysfunction, diabetes, and frailty
Unbiased analysis of senescence associated secretory phenotype (SASP ) to identify common components following different genotoxic stresses
Aging and adipose tissue : potential interventions for diabetes and regenerative medicine
Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue
Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities
The emerging role of senescent cells in tissue homeostasis and pathophysiology
Cellular senescence and the senescent secretory phenotype in age-related chronic diseases
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice
Aging-related inflammation in osteoarthritis
Cellular senescence in type 2 diabetes: a therapeutic opportunity
The fat cell senescence hypothesis: a mechanism responsible for abrogating the resolution of inflammation in chronic disease
Feast and famine: adipose tissue adaptations for healthy aging
Macrophages in age-related chronic inflammatory diseases
Proposed metabolic vicious circle in patients with large myocardial infarcts and high plasma-free-fatty-acid concentrations
Perspective: targeting the JAK/STAT pathway to fight age-related dysfunction
Effect of low-dose rapamycin on senescence markers and physical functioning in older adults with coronary artery disease: results of a pilot study.
Systemic DNA damage response and metabolic syndrome as a premalignant state
Stem cell senescence and regenerative paradigms
Cellular senescence in ageing, age-related disease and longevity
Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus
Phytochemicals suppress nuclear factor-κB signaling: impact on health span and the aging process
Effect of lipopolysaccharides on adipogenic potential and premature senescence of adipocyte progenitors
Developments in our understanding of the effects of growth hormone on white adipose tissue from mice: implications to the clinic
Cellular senescence in aging and age-related disease: from mechanisms to therapy
Deleted in B reast C ancer 1 regulates cellular senescence during obesity
Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues
Mitochondrial dysfunction induces senescence with a distinct secretory phenotype
Impact of growth hormone on regulation of adipose tissue
Senescence-associated secretory phenotype (SASP ) involvement in the development of cancer, aging, and age related diseases
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Curcumin, inflammation, ageing and age-related diseases
Inflammation, ageing and chronic disease
Geroscience: linking aging to chronic disease
Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)
Mitochondrial dysfunction meets senescence
Finding Shangri-La: limiting the impact of senescence on aging
Inflamm-ageing
Characterization of senescence of culture-expanded human adipose-derived mesenchymal stem cells
An experiment to determine the active therapeutic moiety of sulphasalazine
Aging of the human innate immune system in HIV infection
Metabolic syndrome is a real disease and premalignant state induced by oncogenic stresses to block malignant transformation
Mechanisms and metabolic implications of regional differences among fat depots
The role of inflammation in age-related disease
“Inflammaging” as a druggable target: a senescence-associated secretory phenotype—centered view of type 2 diabetes
Antagonizing Effects of Aspartic Acid against Ultraviolet A-Induced Downregulation of the Stemness of Human adipose tissue -Derived Mesenchymal Stem …
Cellular senescence: from physiology to pathology
RETRACTED: Chronic Inflammation: Accelerator of Biological Aging
Senescence associated macrophages and “macroph-aging”: are they pieces of the same puzzle?
Cellular senescence and the biology of aging, disease, and frailty
Targeting senescent cells enhances adipogenesis and metabolic function in old age
Urinary Iodine Concentrations in Mothers and their Term Newborns
Aging and osteoarthritis
Obesity-associated mechanisms of hepatocarcinogenesis
P12 Pathological vascular smooth muscle cells remodelling in murine models of abdominal aortic aneurysm
The aging adipose organ: lipid redistribution, inflammation, and cellular senescence
Ginsenoside Rd attenuates the inflammatory response via modulating p38 and JNK signaling pathways in rats with TNBS-induced relapsing colitis
Impact of cellular senescence signature on ageing research
Metabolic and microenvironment changes in the mammary of calorie restricted, normal weight, and obese mice throughout the lifespan
Senescent cells: a novel therapeutic target for aging and age‐related diseases
… and Metabolic Dysfunction during Aging and Senescence: Effect of lipopolysaccharides on adipogenic potential and premature senescence of adipocyte …
Crossing Boundaries to Propel Tissue Engineering into the Clinic
Mitochondrial damage induces senescence with a twisted arm
Therapeutic effect and mechanism of proanthocyanidins from grape seeds in rats with TNBS-induced ulcerative colitis
Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases
Pathogenesis of hepatocellular carcinoma development in non-alcoholic fatty liver disease
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Aging of the immune system: focus on inflammation and vaccination
Molecular mechanisms of ageing and related diseases
Senescent cells: SASP ected drivers of age-related pathologies
Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging
p21 both attenuates and drives senescence and aging in BubR1 progeroid mice
Stop feeding cancer: pro-inflammatory role of visceral adiposity in liver cancer
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Metabolic control of longevity
Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells
Microbiome–Obesity–Liver Cancer Interaction: Senescence of Hepatic Stellate Cells and Bile Acids Play New Roles
Ameliorative effects of 3, 4-oxo-isopropylidene-shikimic acid on experimental colitis and their mechanisms in rats
Hepatocellular carcinoma and lifestyles
Inflammation and cellular senescence: potential contribution to chronic diseases and disabilities with aging
Toll like receptor signaling in “inflammaging”: microRNA as new players
Depleting senescent cells to combat aging
www. aging-us. com AGING 2016, Vol. 8, Advance
High-throughput screening reveals enzyme and GPCR targets as putative binding sites for d-deprenyl
Adipocytes and neutrophils give a helping hand to pancreatic cancers
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
Anti-inflammatory effects of Pulvis Fellis Suis extract in mice with ulcerative colitis
Ageing and the pathogenesis of osteoarthritis
Aging of mice is associated with p16 (Ink4a)-and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells
Cellular senescence in aging and osteoarthritis: implications for cartilage repair
Oxidative stress and the ageing endocrine system
Clinical strategies and animal models for developing senolytic agents
Liver cancer: connections with obesity, fatty liver, and cirrhosis
Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging
Age-dependent dysregulation of innate immunity
Endothelial progenitor cells: from senescence to rejuvenation
Aging: a common driver of chronic diseases and a target for novel interventions
Increased IL-6 secretion by aged human mesenchymal stromal cells disrupts hematopoietic stem and progenitor cells’ homeostasis
Extracellular microRNAs and endothelial hyperglycaemic memory: a therapeutic opportunity?
The role of oxidative stress and inflammation in cardiovascular aging
Cell autonomous and non-autonomous effects of senescent cells in the skin
A case of rheumatoid arthritis exhibiting accelerating rheumatoid pleurisy during low-dose weekly methotrexate therapy
Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer
The role of senescent cells in ageing
Sowing the seeds of cancer: telomeres and age-associated tumorigenesis
Tim-3: an emerging target in the cancer immunotherapy landscape
Effect of traditional Chinese medicinal enemas on ulcerative colitis of rats
Diabetes and cancer, common threads and missing links
Hepatocellular carcinoma in nonalcoholic fatty liver: role of environmental and genetic factors
Translational research in immune senescence: assessing the relevance of current models
Elimination of p19ARF-expressing cells enhances pulmonary function in mice
The effects of aging on the development of osteoarthritis
Cellular senescence impact on immune cell fate and function
Effects of proanthocyanidins from grape seed on treatment of recurrent ulcerative colitis in rats
Proanthocyanidins from grape seeds modulate the NF-κB signal transduction pathways in rats with TNBS-induced ulcerative colitis
Morphological, molecular and functional differences of adult bone marrow-and adipose-derived stem cells isolated from rats of different ages
The role of insulin resistance in nonalcoholic steatohepatitis and liver disease development–a potential therapeutic target?
Nonalcoholic fatty liver disease: pathogenesis and disease spectrum
The possible mechanisms of Picrasma quassiodes (D. Don) Benn. in the treatment of colitis induced by 2, 4, 6-trinitrobenzene sulfonic acid in mice
Aldosterone induces p21‐regulated apoptosis via increased synthesis and secretion of tumour necrosis factor‐α in human proximal tubular cells
Senescence as a general cellular response to stress: a mini-review
Obesity and liver cancer
Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model
Reversing multiple age-related pathologies by controlling the senescence-associated secretory phenotype of stem cells
Histone macroH2A1. 2 promotes metabolic health and leanness by inhibiting adipogenesis
Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis
Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis
Maternal obesity programs senescence signaling and glucose metabolism in osteo-progenitors from rat and human
Immunosurveillance of senescent cells: the bright side of the senescence program
Obesity and the gut microbiome: pathophysiological aspects
Ageing induced vascular smooth muscle cell senescence in atherosclerosis
Cancer and inflammation: an old intuition with rapidly evolving new concepts
Obesity and cancer pathogenesis
Metabolic consequences of HIV: pathogenic insights
Noncoding RNA control of cellular senescence
Protective effects of 3, 4-oxo-isopropylidene-shikimic acid on experimental colitis induced by trinitrobenzenesulfonic acid in rats
Inflammaging decreases adaptive and innate immune responses in mice and humans
Senescence and the pro-tumorigenic stroma
Siegesbeckia pubescens ameliorates experimental ulcerative colitis in rats by modulating PPARγ.
Therapeutic effect of ginsenoside Rd in rats with TNBS-induced recurrent ulcerative colitis
Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors
Serum n3 polyunsaturated fatty acids are depleted in Crohn’s disease
The cell secretome, a mediator of cell-to-cell communication
Targeting senescent cells: possible implications for delaying skin aging: a mini-review
DNA damage and innate immunity: links and trade-offs
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Protective effect of taurohyodeoxycholic acid from Pulvis Fellis Suis on trinitrobenzene sulfonic acid induced ulcerative colitis in mice
Chronic inflammation, immune escape, and oncogenesis in the liver: a unique neighborhood for novel intersections
Mesenchymal stem cells in regenerative medicine: focus on articular cartilage and intervertebral disc regeneration
Interventions to slow aging in humans: are we ready?
Anti-inflammatory activity and mechanisms of a lipid extract from hard-shelled mussel (Mytilus coruscus) in mice with dextran sulphate sodium-induced colitis
DNA damage response and autophagy: a meaningful partnership
NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies
mTOR signaling from cellular senescence to organismal aging
Erdheim–Chester disease: from palliative care to targeted treatment
Gerosuppressant metformin: less is more
Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents
Workshop report Key data from the 11th International Workshop on Adverse Drug Reactions and Co-Morbidities in HIV
Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy
Immune aging, dysmetabolism, and inflammation in neurological diseases
Anti-inflammatory effects of Huangqin tang extract in mice on ulcerative colitis
Conditioned media from human umbilical cord blood-derived mesenchymal stem cells inhibits melanogenesis by promoting proteasomal degradation of MITF
Speeding up the clock: The past, present and future of progeria
Mathematical integration of protein metabolism in growing lambs
Short telomeres in key tissues initiate local and systemic aging in zebrafish
Modelling age-related metabolic disorders in the mouse
Disease drivers of aging
Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity
Diabetes and aging
Exercise attenuates the major hallmarks of aging
Long noncoding RNAs in diseases of aging
Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation
From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes
Persistent DNA damage‐induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells
Halofuginone reduces the inflammatory responses of DSS-induced colitis through metabolic reprogramming
Obesity and cancer
Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy
Bile acids and the gut microbiome
Aging, clonality, and rejuvenation of hematopoietic stem cells
Dysregulated inflammation as a risk factor for pneumonia in the elderly
Ageing and the telomere connection: An intimate relationship with inflammation
The study of skeletal aging is coming of age: A forum on aging and skeletal health
Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 …
Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression
Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response
SYSTEMIC DNA DAMAGE RESPONSE AND METABOLIC SYNDROME
Secreted microvesicular miR‐31 inhibits osteogenic differentiation of mesenchymal stem cells
Are there roles for brain cell senescence in aging and neurodegenerative disorders?
Effect of Manuka honey and sulfasalazine in combination to promote antioxidant defense system in experimentally induced ulcerative colitis model in rats
Effect of hyperglycemia on hepatocellular carcinoma development in diabetes
NF-κB in aging and disease
Toward the comprehensive understanding of the gut ecosystem via metabolomics-based integrated omics approach
Interleukin‐8 production in tuberculous pleurisy: role of mesothelial cells stimulated by cytokine network involving tumour necrosis factor‐α and interleukin‐1β
Energetic interventions for healthspan and resiliency with aging
Secretome of human fetal mesenchymal stem cell ameliorates replicative senescence
Caloric restriction and aging stem cells: the stick and the carrot?
Exercise enhances wound healing and prevents cancer progression during aging by targeting macrophage polarity
The promise of slow down ageing may come from curcumin
Effects of mimic of manganese superoxide dismutase on 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in rats
Genome-wide chromatin state transitions associated with developmental and environmental cues
Oxidative stress, cellular senescence and ageing
7 Immune Senescence
What Is Homeostasis?
Atypical pyoderma gangrenosum with leukemia
INVESTIGATING MOLECULAR PATHWAYS OF ROS-INDUCED PRO-INFLAMMATORY SENESCENCE IN PREADIPOCYTES
Vascular wall-resident multipotent stem cells of mesenchymal nature within the process of vascular remodeling: cellular basis, clinical relevance, and …
Recombinant HSP70 and mild heat shock stimulate growth of aged mesenchymal stem cells
Senescence in chronic obstructive pulmonary disease
Fibrogenesis and carcinogenesis in nonalcoholic steatohepatitis (NASH): involvement of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinase …
Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention
Telomeres and age-related disease: how telomere biology informs clinical paradigms
Characterization of the human salivary proteome by capillary isoelectric focusing/nanoreversed-phase liquid chromatography coupled with ESI-tandem MS
Macromolecular degradation systems and cardiovascular aging
Acute phase serum amyloid A induces proinflammatory cytokines and mineralization via toll-like receptor 4 in mesenchymal stem cells
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
Understanding The Regulation Of Adipogenesis And Adipocyte Metabolism In Obesity
Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains chromosomal stability over long-term culture
The senescence arrest program and the cell cycle
The posttranslational processing of prelamin A and disease
Caveolae and signalling in cancer
Therapy with multipotent mesenchymal stromal cells protects lungs from radiation-induced injury and reduces the risk of lung metastasis
Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults
From experimental design to functional gene networks: DNA microarray contribution to skin ageing research
Senescence-associated MCP-1 secretion is dependent on a decline in BMI1 in human mesenchymal stromal cells
Tumour biology of obesity-related cancers: understanding the molecular concept for better diagnosis and treatment
Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice
Living Large: What Mouse Models Reveal about Growth Hormone and Obesity
Signaling networks determining life span
Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity
The second international conference “genetics of aging and longevity”
Amniotic epithelial cells: a new tool to combat aging and age-related diseases?
Mesenchymal stem cells in wound repair, tissue homeostasis, and aging
The role and regulation of the nuclear factor kappa B signalling pathway in human labour
Physiological regulation of the heat shock response by glutamine: implications for chronic low-grade inflammatory diseases in age-related conditions
At the stem of youth and health
New Insights into the Management and Therapeutics of Type 2 Diabetes
Epigallocatechin-3-gallate ameliorates rats colitis induced by acetic acid
Cellular and molecular biology of aging endothelial cells
The nuclear lamina in health and disease
The Biology of Aging: Role in Cancer, Metabolic Dysfunction, and Health Disparities
Cellular and molecular basis of the imbalance between vascular damage and repair in ageing and age-related diseases: as biomarkers and targets for new …
Interrater reliability of a clinical scale to assess knee joint effusion
Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?
Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury
Biomarkers and Inflammatory Network in Aging: Targets for Therapies
Implications of multipotent mesenchymal stromal cell aging
Connecting the dots: from DNA damage and repair to aging
Metformin‐mediated increase in DICER1 regulates microRNA expression and cellular senescence
MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1
Identification of senescent cells in the bone microenvironment
Identification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stress
Melatonin and the theories of aging: a critical appraisal of melatonin’s role in antiaging mechanisms
Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes?
Extracellular microRNAs and endothelial hyperglycemic memory: a therapeutic opportunity?
Skin mirrors human aging
miR‐335 correlates with senescence/aging in human mesenchymal stem cells and inhibits their therapeutic actions through inhibition of AP‐1 activity
Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats
Illuminating inflammasome activity in vivo
Metabolic exchanges within tumor microenvironment
Inflammation and atherosclerosis in rheumatoid arthritis
From cellular senescence to age-associated diseases: the miRNA connection
Melatonin reduces endoplasmic reticulum stress and autophagy in liver of leptin‐deficient mice
Modulation of Membrane Transport Systems
The role of chromatin reorganization in the process of cellular senescence
Pleiotropic effects of tocotrienols and quercetin on cellular senescence: introducing the perspective of senolytic effects of phytochemicals
Role of DNA damage in cardiovascular disease
The telomere syndromes
Somatic stem cell aging and malignant transformation–impact on therapeutic application
Organelle Stress and mTOR in Aging-Associated Inflammation
ACC 284
Regulatory roles of miRNAs in aging
Evidences of early senescence in multiple myeloma bone marrow mesenchymal stromal cells
Mechanisms of metastatic tumor dormancy
Liposarcoma
Liposarcomas-proliferation, senescence and the role of DDIT3
Senescence bypass in mesenchymal stem cells: a potential pathogenesis and implications of pro-senescence therapy in sarcomas
Mechanisms of resveratrol-induced inhibition of clonal expansion and terminal adipogenic differentiation in 3T3-L1 preadipocytes
Progressive loss of SIRT1 with cell cycle withdrawal
Targeting Senescent Cells to Improve Human Health
Defining mesenchymal stromal cells responsiveness to IFNγ as a surrogate measure of suppressive potency
The germline/soma dichotomy: implications for aging and degenerative disease
Identifying of the causative genes in spontaneous mutant mouse strains by forward-reverse genetics
Phenylbutyric Acid: simple structure-multiple effects
The role of immunosenescence in the development of age-related diseases
Melatonin reverses H2O2‐induced premature senescence in mesenchymal stem cells via the SIRT1‐dependent pathway
Recent advances in mouse models of obesity-and nonalcoholic steatohepatitis-associated hepatocarcinogenesis
Cellular senescence and vascular disease: novel routes to better understanding and therapy
Telomeres, NAFLD and chronic liver disease
The emergence of geromirs: A group of micrornas implicated in aging
The Role of Stem Cell Genomic Instability in Aging
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic …
Regulation of senescence by microRNA biogenesis factors
Host resistance and immune aging
Coming of age: molecular drivers of aging and therapeutic opportunities
ISSN 0975-413X CODEN (USA): PCHHAX
Finding Ponce de Leon’s Pill: challenges in screening for anti-aging molecules
Thymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation
An Arf-Egr-C/EBPβ pathway linked to ras-induced senescence and cancer
Growth hormone is a cellular senescence target in pituitary and nonpituitary cells
MicroRNAs linking inflamm-aging, cellular senescence and cancer
Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial …
Medial arterial calcification: an overlooked player in peripheral arterial disease
Lessons from Hepatocyte-Specific Cyp51 Knockout Mice: Impaired Cholesterol Synthesis Leads to Oval Cell-Driven Liver Injury
Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy
Inflammasomes: guardians of cytosolic sanctity
As we age: Does slippage of quality control in the immune system lead to collateral damage?
Anti-aging pharmacology: promises and pitfalls
Neovascularization capacity of mesenchymal stromal cells from critical limb ischemia patients is equivalent to healthy controls
Effect of hyperglycemia on hepatocellular carcinoma development in diabetes
Expression of HOXD9 in fibroblast-like synoviocytes from rheumatoid arthritis patients
The Disrupted Steady-State: Tipping the Balance in Favour of Cancer
The Way Forward: Translation
Intervention of aging and its effects on cellular health
DNA damage response and immune defense: links and mechanisms
Towards an evidence-based model of aging
iPSCs as a major opportunity to understand and cure age-related diseases
The biology of aging: 1985–2010 and beyond
DNA damage: from chronic inflammation to age-related deterioration
The emerging role of Notch pathway in ageing: focus on the related mechanisms in age-related diseases
SPEAKER ABSTRACTS
miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53–p21 and p16–pRB pathways
Osteopontin, a key mediator expressed by senescent pulmonary vascular cells in pulmonary hypertension
NF-κB signaling as a driver of ageing
The Cellular Senescence Program
Age-related changes in blood-brain barrier integrity in C57BL/6J mice
Ultrastructural analysis of changes in neurons of the mouse internal anal sphincter during ageing
Age-related changes to lumbosacral spinal cord motoneurons that modulate bladder and bowel functions in male C57BL/6 mice
The metabolic regulation of cellular ageing
The inflammatory network: bridging senescent stroma and epithelial tumorigenesis
Cellular senescence and inflammation in aging and age-related disease
Influence of aging on the quantity and quality of human cardiac stem cells
Prospects and challenges for the use of stem cell technologies to develop novel therapies for Parkinson disease
Hypoxia-inducible histone lysine demethylases: impact on the aging process and age-related diseases
Autophagy and cancer metabolism
Assessing cell and organ senescence biomarkers
Sphingolipids in inflammation: pathological implications and potential therapeutic targets
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Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer
Cellular senescence in cardiovascular diseases: potential age-related mechanisms and implications for treatment
Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells
Pathogenesis of osteoarthritis
Better living through chemistry: caloric restriction (CR) and CR mimetics alter genome function to promote increased health and lifespan
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence
Intestinal anti-inflammatory effect of the rhizome extracts of Menispermum dauricum DC. on trinitrobenzene sulfonic acid induced ulcerative colitis in mice
Biosprays: From the biomedical to the clinical sciences
Influence of age and physical fitness on miRna-21, TGF-ß and its receptors in leukocytes of healthy women.
Caspase inhibition switches doxorubicin-induced apoptosis to senescence
MicroRNAs as mediators of the ageing process
Modelling ageing and age-related disease
PROTECTIVE EFFECT OF RICE BRAN WATER EXTRACT ON PANCREAS OF RATS FED A HIGH-FAT DIET
New objective findings after whiplash injuries: high blood flow in painful cervical soft tissue: an ultrasound pilot study
Genome integrity in aging: human syndromes, mouse models, and therapeutic options
Conditioned medium derived from rat amniotic epithelial cells confers protection against inflammation, cancer, and senescence
Endothelial cell senescence and thrombosis: ageing clots
A Fungal Glycosphingolipid Directly Activates Natural Killer T Cells and Rapidly Induces Airways Disease
NAFLD and hepatocellular Carcinoma: how big a problem is this really?
Mast cells and histamine are triggering the NF-κB-mediated reactions of adult and aged perilymphatic mesenteric tissues to acute inflammation
Oral submucous fibrosis: Review on mechanisms of pathogenesis and malignant transformation
Extracellular vesicles in lung microenvironment and pathogenesis
Vascular endothelial senescence: from mechanisms to pathophysiology
Autoimmune atherosclerosis in 3D: how it develops, how to diagnose and what to do
Physiological roles of the DNA demethylation-associated proteins Gadd45a and Ing1
Stress-induced premature senescence of endothelial and endothelial progenitor cells
Regulation of Senescence by microRNAs
Muscle stem cell aging: regulation and rejuvenation
kk journal of experimental biology.
2.20 Behcet’s disease and miscellaneous rheumatic conditions
Inflammatory bowel disease part I: ulcerative colitis–pathophysiology and conventional and alternative treatment options
The Buck Institute: An inside look
Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells
Orphan technology: Unfunded early-stage bioscience is dropped off at the firehouse
Computational approaches for the transcriptomics, proteomics and epigenetic analysis in adult stem cells
The secret lives of stem cells: Unraveling the molecular basis of stem cell aging
Positive and negative effects of cellular senescence during female reproductive aging and pregnancy
Global profiling and relative quantifiction of histones, histone PTMs and histone-modifying enzymes in mesenchymal stem cells using LC-MS/MS and a novel …
The 10th World Congress on Inflammation
Ms. No.: METHODS-D-15-00125 R1–Revised Version
Are aging biomarkers clinically relevant in oncogeriatrics?
Apocrine secretion: new insights into an old phenomenon
Molecular links between cellular senescence, longevity and age-related diseases–a systems biology perspective
Practical Laboratory Medicine
Stop Aging Disease! ICAD 2014.
PROGRESS REPORT ON THE ROLE OF MITOCHONDRIAL ISOCITRATE DEHYDROGENASE 2 IN AGE-RELATED HEARING LOSS IN MICE
Impact of physical activity on immune function and inflammation in the elderly
Four faces of cellular senescence
Interventions to slow aging in humans: Are we ready?
Determination of serum visfatin level in patients with Behcet disease, comparing with normal population
Senescent fibroblast-derived Chemerin promotes squamous cell carcinoma migration
DNA damage: a main determinant of vascular aging
The Role of Estrogen Deficiency in Skin Aging and Wound Healing
Comparative analysis of gene expression data reveals novel targets of senescence-associated microRNAs
Accelerated telomere shortening in acromegaly; IGF-I induces telomere shortening and cellular senescence
Salvianolic acid B restored impaired barrier function via downregulation of MLCK by microRNA-1 in rat colitis model
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
Anti-stress gene response in cell and tissue ageing: role of transcription factor NF-E2-related factor-2 and effect of dietary activators
Protective Effect of Paronychia argentea L. on Acetic Acid Induced Ulcerative Colitis in Mice by Regulating Antioxidant Parameters and Inflammatory Markers
7th Joint Meeting of the European Tissue Repair Society (ETRS) with the Wound Healing Society
Human Amniotic Fluid Mesenchymal Stromal cells (AF-MSCs) are Less Prone to in vitro Senescence Process Compared with Bone Marrow MSCs
The central role of muscle stem cells in regenerative failure with aging
Modulation of ageing characteristics with an anti-ageing compound
Insulin pathway and its correlation with ageing and longevity
Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype
Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy
Stem cells and cancer stem cells
Nutritional Modulators of Cellular Senescence In Vitro
Non‐cell autonomous or secretory tumor suppression
The Aging Superorganism
Systemic problems: a perspective on stem cell aging and rejuvenation
Modulators of cellular senescence: mechanisms, promises, and challenges from in vitro studies with dietary bioactive compounds
Pharmacotherapeutics ECG of the Month
Molecular Mechanisms of Lycopene Actions on Liver Disease Outcomes
Pathophysiological fundamentals of diabetic cardiomyopathy
The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases
The role of miRNAs in common inflammatory arthropathies: osteoarthritis and gouty arthritis
Similarities in gene expression profiles during in vitro aging of primary human embryonic lung and foreskin fibroblasts
Rescuing the regenerative capacity of human mesenchymal stem cells from the elderly
Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response
Nuclear lamina defects cause ATM-dependent NF
Interventions for age-related diseases: Shifting the paradigm
An Arf-Egr-C
Biomolecular bases of the senescence process and cancer. A new approach to oncological treatment linked to ageing
Aging, Immunosenescence, and Cancer
A causal role of ATM-and NEMO-dependent NF-κB activation in DNA damage-induced senescence and aging
Effect of bisphenol A on stress-induced premature senescence
Progerin Expression Disrupts Critical Adult Stem Cell Functions that Mediate Tissue Repair Primarily through a Mechanism that Permanently Farnesylates Lamin A
Systemic DNA damage responses in aging and diseases
Osteoarthritis in the Elderly
MDM2 levels modulate the cellular senescence response to CDK4 inhibition
Functional-structural plant modeling
Placental origins of chronic disease
Inflammatory dysregulation and cancer: From molecular mechanisms to therapeutic opportunities
The Role of Integrated Omics in Elucidating the Gut Microbiota Health Potentials
Allogeneic mesenchymal stem cells transplantation in patients with refractory RA
Stress-Induced Senescence: Molecular Pathways
Neovascularization capacity of mesenchymal stromal cells from critical limb ischemia patients is equivalent to healthy controls
Twist proteins as oxidative and hypoxic stress regulators
The gut microbiota and the liver: implications for clinical practice
The Epigenome and Aging
Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants
Glenn Workshop on the Biology of Aging and AFAR Grantee Conference| JOINT MEETING
The hallmarks of fibroblast ageing
Signaling Networks Controlling Cellular Senescence
Evidences of Early Senescence in Multiple Myeloma Bone Marrow
Systemic administration of WY-14643, a selective synthetic agonist of peroxisome proliferator activator receptor-alpha, alters spinal neuronal firing in a rodent model of …
Development of a mouse model for Hutchinson-Gilford progeria syndrome reveal defects in adult stem cell maintenance
A potential role for miR-31 in osteoblastic transition of vascular smooth muscle cells and cortisol-induced osteoporosis
Senescent mesenchymal stem cells promote colorectal cancer cells growth via galectin-3 expression
BLT2 Protects Skin from the Damage Caused by Type 2 Diabetes Hyperglycemia by Increasing NO Production Through the nNOS Expression
Molecular mechanisms of aging in MTDNA mutator mice
Reversing stem cell aging: Implications for vascular regeneration
Targeting the tumor stroma as a novel therapeutic approach for prostate cancer
The Role of Macrophage Migration Inhibitory Factor in Osteoarthritis
Evidence supporting the utility of blood cell respiratory capacity as a systemic marker of mitochondrial health and biological age
Circadian molecular clock in lung pathophysiology
Stop Aging Disease! ICAD 2014
Investigating the differential instructive roles of WT1’s isoforms
Osteoporosis and mechanisms of skeletal aging
Functional Enrichment Analysis
mberHappily (n) ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
Skin disease in laminopathy-associated premature aging
Cellular and Molecular Mechanisms of Chronic Inflammation in Aging of Skeletal Muscle
Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells
Histone methylation and aging: lessons learned from model systems
Regulation of Phospholipase Isozymes by Nuclear Factor-κB in Human Gestational Tissues in Vitro
Fluorescence Spectroscopy
Psoriasis and inflammatory bowel disease: links and risks
Prelamin A accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle …
SIRT1 in endothelial cells as a novel target for the prevention of early vascular aging
Cellular senescence as the causal nexus of aging
MicroRNAs Regulate p21Waf1/Cip1 Protein Expression and the DNA Damage Response in Human Embryonic Stem Cells
Basic Research
Nuclear matrix, nuclear envelope and premature aging syndromes in a translational research perspective
Relationships Among Body Mass Index, Nutrition, Internalizing Symptoms, and Ethnic Identity of Cherokee Youth Attending a Private American Indian Secondary …
The role of the stress response gene Gadd45b in senescence
False discovery rate (FDR)
FBA Analysis, Plant-Pathogen Interactions
Influence of aging on proliferation, pluripotency, immunogenic profiles from bone marrow mesenchymal stem cells
Macrophage migration inhibitory factor regulates AKT signaling in hypoxic culture to modulate senescence of human mesenchymal stem cells
Cell and molecular aging
Loss of HuR leads to senescence-like cytokine induction in rodent fibroblasts by activating NF-κB
Role of the nuclear envelope in regulation of ageing
Chemotherapy-and Radiation-Induced Accelerated Senescence: Implications for Treatment Response, Tumor Progression and Cancer Survivorship
Selenium and Senescence: Centering on Genome Maintenance
Author statement
Mechanisms of action of anti-TNF-α antibodies in inflammatory bowel disease
Immortality: Myth or becoming Reality
Skin, Mucosa and Menopause
SUPPLEMENTARY TABLES
Proteome analysis of formalin-fixed and paraffin-embedded tissue
Framework Region (FR-IMGT)
Frequent Pattern Mining
Founders Effect
Fisher’s Test
Frequency
Frequentist Approach
Fitness
Forward-scattered Light (FSC)
Fluorescent Markers
Fluorescence Microscopy
Functional/Signature Network Module for Target Pathway/Gene Discovery
Forward and Inverse Parameter Estimation for Metabolic Models
Feature Selection
Fitness Function
Feedback Regulation
Fibroblasts
Feasibility
Functional Modules and Complexes
FunctionalityType
Flux Balance Analysis
Fokker–Planck Equation
Faceted Browsing
Fluorescence-activated Cell Sorting
Flow Cytometry
Frame Language
Function, biological
Feed Forward Loop
Fluorophore
Fluorescence Microscope
False Positive Rate
Fuzzy Logic
Functional
Flux Control Coefficient
Fluorescence
Functor
Fourier Transform Infrared Microspectroscopy (FTIR)
FuGE
Foundational Model of Anatomy
Floquet Multiplier
Function, Distributed
9.1 Gut Microbiota
Ageing and inflammation with focus on end-stage renal diseases: genetic and epigenetic factors
The pleiotropic effects of HMG-CoA reductase inhibitors in inflammatory arthritis
Assessing Pain and Inflammation in Arthritis Using Novel Imaging Methods
The skin as a mirror of the aging process
Hyperalgesia and allodynia to superficial and deep-tissue mechanical stimulation within and outside of the UVB irradiated area in human skin
IL-6 secreted from senescent mesenchymal stem cells promotes proliferation and migration of breast cancer cells
The role of telomere damage in cardiomyocyte ageing
Gut Microbiota and HCC
Contributions of telomere biology to human age-related disease
Adult cardiac stem cells: identity, location and potential
Human Population Studies of Transcriptome-wide Expression in Age-related Traits
The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor
The effects of chronic and acute toxicological exposures on the expression of the tumor suppressor p16INK4a
p53 and NF-κB: different strategies for responding to stress lead to a functional antagonism
P13. 2
The role of mitochondria in the regulation of gamma rays induced mTOR-dependent senescence
Regulation of Forkhead BOX O tumor suppressors by Reactive Oxygen Species
CSI-01–Cell Cycle & Checkpoints
A novel approach towards finding regulatory microRNAs during phagosomal maturation in infection.
The Impact of Physical Activity and Antioxidants on Tumor-Skeletal Muscle Crosstalk during Cancer: Deciphering Signaling Pathways Involved in Tumor Growth and …
Par Proteins in Tumor Formation and Progression
Identification and characterization of senescence-associated microRNAs in a mouse model of the XFE Progeroid Syndrome
Immunoregulatory network and cancer-associated genes: molecular links and relevance to aging
Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast …
Telomere fragment induced amnion cell senescence: a contributor to parturition?
Islet Biology/Insulin Secretion
Telomere dysfunction: Role in arterial aging and hypertension
Colorectal cancer-promoting activity of the senescent peritoneal mesothelium
Senescent Carcinoma Associated Fibroblasts Up-regulate Interleukin 8 to Enhance Pancreatic Cancer Progression
MOVD 2013
The Role of Prolactin in the Cellular Response to DNA Damaging Agents
Studies on the Developmental Changes in Parvalbumins of the Catfish, Heteropneustes fossilis (Bloch)
Forum on aging and skeletal health: summary of the proceedings of an ASBMR workshop
Analysis of temporal gene expression during Bacillus subtilis spore germination and outgrowth
Analysis of gene expression during aging of CGNs in culture: implication of SLIT2 and NPY in senescence
HIF1α regulates Mitochondrial biogenesis and Cellular senescence induced by Gamma Radiation
Roles of senescence escape and epigenetic modifications in liver cancer
Autophagy and inflammation in the pathogenesis of idiopathic dilated cardiomyopathy
Interventions for age-related diseases: shifting the
Differential expression of cellular senescence markers in the assessment of breast cancer development
Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation
The role of Inhibitor of DNA binding 4 (Id4) in mammary gland development and breast cancer
The Role of Photodynamic Therapy in Wound Healing and Scarring in Human Skin
Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp‐9) and effector caspases (casp‐3/casp‐7) and PARP in UVR …
Pathogenesis of intervertebral disc degeneration
Thymic involution perturbs negative selection and leads to chronic inflammation
Elucidating Molecular Changes in CD8+ T cells During Aging
High-throughput Screening of Age-related Changes in Caenorhabditis elegans
Causes, consequences, and reversal of immune system aging
Senescence and apoptosis: dueling or complementary cell fates?
Frequency of the cancer-resistant phenotype in SR/CR mice and the effect of litter seriation
Understanding the roles of Non-homologous end joining and p53 after DNA damage
IGF-binding protein 2–oncogene or tumor suppressor?
Regulatory Mechanisms of NK-Cell-Mediated Immune Surveillance of Senescent Cells
Suppression of autophagy during liver regeneration impairs energy charge and hepatocyte senescence in mice
Mechanisms of tissue injury in autoimmune liver diseases
Telomere dysfunction and senescence in the ageing lung and age-related lung disease
HDAC 1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways
Poster session 3
The senescent cell induced bystander effect
The Function and Regulation of Senescent Stromal-Derived Osteopontin
Effects of chemotherapy and radiotherapy in rectal cancer: significance of different cellular outcomes in tumor behavior
Polycomb Repressive Complex 1 Coordinates Enhanced Replication and Transcription in Transit Amplifying Chondrogenic Progenitors.
Molecular Tuning Of Telomerase Activity In Senescent Human T Cells
Role of squamous cell carcinoma antigen (SCCA) in oncogenic Ras-mediated tumorigenesis
Increased oxidative and nitrative stress accelerates aging of the retinal vasculature in the diabetic retina
The role of calcification regulatory proteins in the arterial stiffening of chronic kidney disease stages 3 & 4
Age-like Phenotype of Microglia During HIV-1 Infection
Characterisation of the molecular and functional changes
The biology of aging: implications for diseases of aging and health care in the twenty-first century
Cytokine and nitric oxide production in inflammatory arthritis
Anti-Aging Effects of the Transcendental Meditation Program: Analysis of Ojas Level and Global Gene Expression
Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression
The diet-microbiota-metabolite axis regulates the host physiology
Role of stromal fibroblasts in prostate carcinoma progression and metabolic reprogramming of cancer cells
Regulation and inhibition of pro-tumorigenic microenvironments
Metal-induced oxidative stress in human fibroblasts: A role in cellular ageing
EVALUATING THE ROLE OF NF-êB SUPPRESSION IN AMELIORATING MAMMALIAN DISEASE: AN EXAMINATION OF INFLAMMATORY BOWEL DISEASE AND …
Session held on 9 July 2016
MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation
Molecular mechanism underlying the tumor-promoting functions of carcinoma-associated fibroblasts
Understanding the pathophysiology and challenges of development of medical countermeasures for radiation-induced vascular/endothelial cell injuries: report of a …
Regulation and Inhibition of Pro-Tumorigenic Microenvironments
Changes in DNA methylation patterns in mammals with senescence, ageing and energy restriction
Methamphetamine accelerates cellular senescence and aging through CYP2D-dependent stimulation of ceramide biosynthesis
Program Committee: Sabine Fleming Markus Boehm Knut Schaekel Martin Metz Thomas Tueting
Muscle ageing and anabolic response in the context of healthy and chronically HIV infected individuals
Pathway Profiling Of Replicative And Induced Senescence
Role of Tumor Suppressor DMP1 in the Initiation and Progression of Breast Cancer
Revista de
Endogenous retroelements in cellular senescence and related pathogenic processes: promising drug targets in age-related diseases
Interactions between mitochondria and inflammatory factors during cellular senescence
Using drug treatments to control genome behaviour in normal and Hutchinson-Gilford Progeria Syndrome fibroblasts, with and without hTERT immortalisation
The chronic lymphocytic leukemia clone disrupts the bone marrow microenvironment
Understanding vascular diseases: lessons from premature aging syndromes
Epigenetic mechanisms of longevity and aging
The role of DNA damage and repair in aging through the prism of Koch-like criteria
Nutritional roles of selenium in cellular and mouse aging
Anisotropy in the anodic oxidation of silicon in KOH solution
Tumor Microenvironment
Investigating the role of DNA polymerase beta in the aging phenotype of Down syndrome
Diamond Sponsor
EXTRACELLULAR MATRIX PROTEINS AND EPITHELIAL CELL PLASTICITY IN PROGRESSION OF BREAST AND PROSTATE CANCER
Noncoding RNA in age-related cardiovascular diseases
Identification and characterisation of telomere regulatory and signalling pathways after induction of telomere dysfunction
Activity and controlled delivery of epigallocatechin 3-gallate in the treatment of degenerative disc disease
State-of-the-Art Lecture
Whose place is it?: examining the socio-spatial geography of obesity in young adults for an Australian context.
Tumor Promoting Aspects of Senescence in Cancer Progression
Long noncoding RNA H19 mediates melatonin inhibition of premature senescence of c‐kit+ cardiac progenitor cells by promoting miR‐675
Higher-Order Unfolding of Peri/Centric Satellite Heterochromatin is an Early and Consistent Event in Cell Senescence: A Dissertation
Poster session 2
Hallmarks of progeroid syndromes: Lessons from mice and reprogrammed cells
Proinflammatory cytokines in breast cancer: mechanisms of action and potential targets for therapeutics
Nitrous oxide analgesia for bone marrow aspiration and biopsy–A randomized, controlled and patient blinded study
15th International Biennial Congress of the METASTASIS RESEARCH SOCIETY
PLATFORM PRESENTATIONS
The Genetic Landscapes of Inflammation-Driven Gastrointestinal Tract Cancers
The senescent microenvironment promotes the emergence of heterogeneous cancer stem-like cells
Mutual Reinforcement Between Telomere Capping and Canonical Wnt Pathway Activity in the Intestinal Stem Cell Niche
The role of nitrosative and metabolic stress in vascular cell senescence
Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human aging
MMP-2, MMP-9 production was significantly elevated by fibroblast cells isolated from rheumatoid arthritis patient when co-cultured with monocyte (THP-1) with …
Evaluating the physiological reserves of older patients with cancer: the value of potential biomarkers of aging?
POSTER PRESENTATIONS-Sunday, December 7
Array-based transcriptional analysis of Clostridium sporogenes UC9000 during germination, cell outgrowth and vegetative life
Pancreatic Dysfunction in Shwachman-Diamond Syndrome
The wound healing, chronic fibrosis, and cancer progression triad
Senescence suppressors: their practical importance in replicative lifespan extension in stem cells
Contributions of Activated Hepatic Stellate Cells to Hepatocarcinogenesis
Principles of Medical Management of Ulcerative Colitis
Proceedings of the 26th annual meeting Chiba, Japan, October 18–20, 1984
Roles of the ING1 Epigenetic Regulator in Breast Cancer
Directions in Post-Traumatic Arthritis
Metabolic regulation of intestinal stem cell function in Drosophila melanogaster
Senescent endothelial cells: Potential modulators of immunosenescence and ageing
Genotype distribution-based inference of collective effects in genome-wide association studies: insights to age-related macular degeneration disease …
Sustained low-dose treatment with the histone deacetylase inhibitor LBH589 induces terminal differentiation of osteosarcoma cells
The multiple roles of A-type lamins in cellular aging, cell cycle progression and the DNA damage response.
Loss of the osteogenic differentiation potential during senescence is limited to bone progenitor cells and is dependent on p53
Podocyte Injury Causes Chronic Kidney Disease in the Ercc1 Deficient Mouse Model of Accelerated Aging
Biological ageing, inflammation and nutrition: how might they impact on systemic sclerosis?
Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level
The role of chondrocyte senescence in osteoarthritis
A senescent cell bystander effect: Senescence‐induced senescence
Changes in regenerative capacity through lifespan
Cancer, Senescence, and Aging: Translation from Basic Research to Clinics
Accumulation of spontaneous γH2AX foci in long-term cultured mesenchymal stromal cells
Extracellular matrix and liver disease
Programmed cell senescence during mammalian embryonic development
Role of MicroRNA-146a in Vascular Inflammation and Atherosclerosis
The effect of radiation on cellular ageing
Programmed cell death in aging
Update on the mechanisms of action of anti‑TNF‑α antibodies and their clinical implications in inflammatory bowel disease
Clinical Investigation Program RCS-MED-300 (R1)
Analysis of Temporal Gene Expression
Postnatal Hdac3 deficiency in chondrocytes alters cortical bone architecture and increases articular cartilage thickness with age
EMT and oxidative stress: a bidirectional interplay affecting tumor malignancy
Regulation of 11β-Hydroxysteroid Dehydrogenase Type 1 and 2 in Rheumatoid Arthritis
Impacts of Aging and Inflammation on Mycobacterium tuberculosis Control
A review of melatonin as a suitable antioxidant against myocardial ischemia–reperfusion injury and clinical heart diseases
Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging
Integrative analysis of longevity, age-related diseases and aging-associated processes: Construction of the NetAge database
SNEVPrp19/PSO4 deficiency increases PUVA‐induced senescence in mouse skin
miR‐17, miR‐19b, miR‐20a, and miR‐106a are down‐regulated in human aging
Pašatjaunošanās un paātrinātas novecošanās attiecības normālās un vēža šūnās pēc DNS bojājuma
Circulating microRNAs as novel biomarkers for bone diseases–Complex signatures for multifactorial diseases?
Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis
Time-and Concentration-dependent response of a liver cell line to Benzo (a) pyrene
Practical alternatives to chronic caloric restriction for optimizing vascular function with ageing
Manipulation du métabolisme énergétique dans les leucémies aiguës myéloïdes: mitochondrie, apoptose et mécanisme d’action de la metformine
Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts
Intervention in Genotoxic Stress–Induced Senescence by Cordycepin Through Activation of eIF2α and Suppression of Sp1
p62: linking protein homeostasis and the DNA damage response during ageing
Molecular basis of Osteoarthritis and aspects of cellular senescence in disease
Etude du facteur de réparation de l’ADN, Xeroderma pigmentosum du groupe C (XPC), dans les cellules souches hématopoïétiques
HIV-1 Infection, Antiretroviral Therapies, and HIV-Associated Atherosclerosis
The role of the transcriptional regulation of stromal cells in chronic inflammation
Cell ageing: a flourishing field for neurodegenerative diseases
Senescence of bone marrow mesenchymal stromal cells is accompanied by activation of p53/p21 pathway in myelodysplastic syndromes
Rat retinal transcriptome: effects of aging and AMD-like retinopathy
Aging of the liver: what this means for patients with HIV
Pharmacology and biochemistry of salicylates and related drugs
A report to inform the development of a clinical practice guideline for rehabilitation post total knee arthroplasty in a South African public hospital
Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging‐related diseases
Cellular responses to zinc involving the transcription factor ZNF658 and its target genes
Determining the role of scavenger receptor class B type I as a source of cholesterol for de novo androgen synthesis in castration-resistant prostate cancer
Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells
Aging and the Host Response to Implanted Biomaterials
A role for epigenetics in aging and the age-dependent response to ionizing radiation
Interleukin 6 signaling regulates promyelocytic leukemia protein gene expression in human normal and cancer cells
Mechanisms of microRNAs in atherosclerosis
Mechanisms of Ageing and Development
Telomeres and telomerase: their mechanisms of action and the effects of altering their functions
Lifespan‐extending caloric restriction or m TOR inhibition impair adaptive immunity of old mice by distinct mechanisms
Fourth International Ankle Symposium, July 16–18, 2009, Sydney, Australia
Telomeres, Aging, and Nutrition
Perspectives in pain research 2014: neuroinflammation and glial cell activation: the cause of transition from acute to chronic pain?
On the Role of Prelamin A in the Heart
Therapeutic effects and the underlying mechanisms of qing-dai powder against experimental colitis in mice
Role of Gut Microbiome in the Modulation of Environmental Toxicants and Therapeutic Agents
43nd Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung eV (ADF)
furanosidase f
Stellate cells
Pressure and cold pain threshold reference values in a large, young adult, pain-free population
The ENRGISE Pilot Study Protocol
A Comparative Analysis of Stress Granule Assembly in Replicative and Stress-Induced Premature Senescence
Mutant lamin A links prophase to a p53 independent senescence program
Identification and characterization of downstream effector protein (s) regulated by p53 and pRb
Long-term efficacy of spironolactone on pain, mood, and quality of life in women with fibromyalgia: An observational case series
Telomere shortening and immune activity in war veterans with posttraumatic stress disorder
KAROLINSKA INSTITUTET, STOCKHOLM, SWEDEN
Interplay between the myc oncoprotein, cyclin-dependent kinases and e3 ubiquitin ligases
Calcitonin gene-related peptide (CGRP) in age-associated vascular inflammation and leukocyte trafficking
The Contribution of DNA Interstrand Crosslinks to Aging
ART. IV.–A Statistical Contribution to our knowledge of Abscess, and other Diseases Consequent upon the Lodgment of Foreign Bodies in the Appendix Vermiformis …
Molecular Mechanisms of Cancer Progression: The Central Role of the Retinoblastoma Family Members
Determination of Autoantibody IgG Subclass and Partial Sequence using Multi-affinity Purification with Multi-enzymatic Digestion by LC-MS
Investigating the role of mitochondrial respiratory chain activity and mitochondrial DNA damage in skin ageing
Prevalence of lumbo-pelvic pain and factors associated with it in cyclists in Johannesburg
Health Ballistics: Multiple Reference Point Informed Probability Theory
Translational Science 2014 Meeting Abstracts
Proteomic profiling following cryopreservation
Functional interaction between FOXO4 and p53 in response to oncogenic BRAF signaling
Translational Science 2014 Meeting Abstracts
Mechanism of Tumorigenesis by Cancer-Associated Mutations of INI1/SMARCB1, a Component of the SWI/SNF Chromatin Remodeling Complex
Ecology of juvenile salmon in shallow tidal freshwater habitats in the vicinity of the Sandy River delta, lower Columbia River, 2008
The role of bone morphogenetic protein 4 in the pathogenesis of choroidal neovascularization in age-related macular degeneration
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis
Sarcopenic obesity or obese sarcopenia: a cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the …
Cellular Senescence Biomarker p16INK4a+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women
Expansion of adipose tissue ‐derived stromal cells at “physiologic” hypoxia attenuates replicative senescence
Age-induced changes in white, brite, and brown adipose depots: a mini-review
adipose tissue inflammation in aging
Rare progerin-expressing preadipocytes and adipocytes contribute to tissue depletion over time
Cellular aging contributes to failure of cold-induced beige adipocyte formation in old mice and humans
Healthy ageing in 2016: Obesity in geroscience—is cellular senescence the culprit?
Micro-RNAS regulate metabolic syndrome-induced senescence in porcine adipose tissue -derived mesenchymal stem cells through the P16/MAPK pathway
Therapeutic doses of doxorubicin induce premature senescence of human mesenchymal stem cells derived from menstrual blood, bone marrow and adipose tissue
Growth hormone’s effect on adipose tissue : quality versus quantity
Aging, cell senescence, and chronic disease: emerging therapeutic strategies
Neovascular deterioration, impaired NADPH oxidase and inflammatory cytokine expression in adipose-derived multipotent cells from subjects with metabolic …
Dietary restriction ameliorates age-related increase in DNA damage, senescence and inflammation in mouse adipose tissue y
Fisetin is a senotherapeutic that extends health and lifespan
adipose tissue -derived extracellular fraction characterization: biological and clinical considerations in regenerative medicine
Fat depot-specific differences of macrophage infiltration and cellular senescence in obese bovine adipose tissue s
Source of chronic inflammation in aging
Aging impairs beige adipocyte differentiation of mesenchymal stem cells via the reduced expression of Sirtuin 1
Maternal high calorie diet induces mitochondrial dysfunction and senescence phenotype in subcutaneous fat of newborn mice
Reduction of premature aging markers after gastric bypass surgery in morbidly obese patients
Age-and tissue-specific expression of senescence biomarkers in mice
Senolytics improve physical function and increase lifespan in old age
Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells
ANGPTL2―A New Causal Player in Accelerating Heart Disease Development in the Aging―
Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress
Cellular senescence: a translational perspective
Rejuvenating senolytics
Regulation of lipogenesis in human adipose tissue : Effect of metabolic stress, dietary intervention and aging.
Cellular senescence in osteoarthritis pathology
Metabolic memory of dietary restriction ameliorates DNA damage and adipocyte size in mouse visceral adipose tissue
Aging of Brown and Beige/Brite adipose tissue
Impact of senescence‐associated secretory phenotype and its potential as a therapeutic target for senescence‐associated diseases
Cellular Senescence: At the Nexus of Mechanisms of Age-and Obesity-Related Metabolic Dysfunction
The Progressive Low Chronic Inflammation On Oral Tissues In Elderly
High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation
Basic research: killing the old: cell senescence in atherosclerosis
Cellular senescence: implications for metabolic disease
Melatonin regulates PARP 1 to control the senescence‐associated secretory phenotype (SASP ) in human fetal lung fibroblast cells
Examination of the Inhibitory Protein P21 in Omento Fat as an Indication of Adipocyte Proliferation
Augmentation of Dermal Wound Healing by adipose tissue -Derived Stromal Cells (ASC)
Cell-free therapy with the secretome of adipose tissue -derived stem cells in rats’ frozen-thawed ovarian grafts
The Complexity of adipose tissue
Targeting cellular senescence prevents age-related bone loss in mice
Targeting our aging cells to treat metabolic disease
Different response to hypoxia of adipose-derived multipotent cells from obese subjects with and without metabolic syndrome
Mitochondria in cell senescence: is mitophagy the weakest link?
Diabetes and Adipocyte Dysfunction
Nonalcoholic fatty liver disease promotes hepatocellular carcinoma through direct and indirect effects on hepatocytes
Short-term sustained hyperglycaemia fosters an archetypal senescence-associated secretory phenotype in endothelial cells and macrophages
Senescence and aging: Causes, consequences, and therapeutic avenues
A summary of the Proceedings of the Thirteenth International Symposium on the Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria July 17–22, 2016
Killing the old: cell senescence in atherosclerosis
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463
Parallels Between Skeletal Muscle and Bone Aging
Aging, obesity, and inflammatory age-related diseases
Molecular pathology endpoints useful for aging studies
Cellular senescence in postmitotic cells: beyond growth arrest
Senescent cells: an emerging target for diseases of ageing
Prevention of senescence in vasculature through quiescence
Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri
Inflammageing and metaflammation: the yin and yang of type 2 diabetes
Chronic inflammation and sarcopenia: A regenerative cell therapy perspective
Ageing: from inflammation to cancer
Senotherapy: growing old and staying young?
Down-regulation of guanylate binding protein 1 causes mitochondrial dysfunction and cellular senescence in macrophages
Cellular senescence: Molecular mechanisms and pathogenicity
Anti-inflammatory effect of Chang-An-Shuan on TNBS-induced experimental colitis in rats
Senescent B cells in aging and age-related diseases: their role in the regulation of antibody responses
The fountain of youth by targeting senescent cells?
HIV-associated cellular senescence: a contributor to accelerated aging
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Activated tissue-resident mesenchymal stromal cells regulate natural killer cell immune and tissue-regenerative function
Immunosenescence induced by plasma from individuals with obesity caused cell signaling dysfunction and inflammation
Circadian Disruption, Sleep Loss, and Low-Grade Inflammation
Histone MacroH2A1: a chromatin point of intersection between fasting, senescence and cellular regeneration
PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C
p16 (Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli
Novel Role of Blackberries in Senescence and Atherosclerosis in ApoE-/-Mice
The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease
Cellular senescence in renal ageing and disease
Quantitative analysis of cellular senescence in culture and in vivo
Ketone bodies mimic the life span extending properties of caloric restriction
Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism
Gut microbiota and mTOR signaling: insight on a new pathophysiological interaction
Gut microbiota, fatty liver disease, and hepatocellular carcinoma
Increase in tumor suppressor Arf compensates gene dysregulation in in vitro aged adipocytes
Inhibiting cellular senescence: a new therapeutic paradigm for age-related osteoporosis
The Na/K-ATPase oxidant amplification loop regulates aging
Role of lncRNAs in aging and age‐related diseases
TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion
Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer
The impact of senescence-associated T cells on immunosenescence and age-related disorders
Study on the therapeutic effects of salicylazosulfapyridine on ulcerative colitis in rats
Emerging metabolic risk factors in hepatocellular carcinoma and their influence on the liver microenvironment
Low-grade inflammation in the relationship between sleep disruption, dysfunctional adiposity, and cognitive decline in aging
Musculoskeletal senescence: a moving target ready to be eliminated
Inflammatory response in the CNS: friend or foe?
Inflammation-accelerated senescence and the cardiovascular system: mechanisms and perspectives
Biphasic modeling of mitochondrial metabolism dysregulation during aging
Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence
Mitochondrial peptides modulate mitochondrial function during cellular senescence
Senescence of mesenchymal stem cells
Sirtuins, a promising target in slowing down the ageing process
Endothelin receptor type b blocker attenuates severity of osteoarthritis by clearance of senescent cells
The Rbm38-p63 feedback loop is critical for tumor suppression and longevity
Identification of senescent cell surface targetable protein DPP4
Caloric Restriction, Sirtuins, and Ageing
5-methoxytryptophan protects MSCs from stress induced premature senescence by upregulating FoxO3a and mTOR
SCAMP4 enhances the senescent cell secretome
Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk
Investigating the Role of NRIP1 in Skin Aging: Depletion of NRIP1 Delays Senescence, Reduces Inflammation and Enhances Autophagy in Adipocytes
The role of cellular senescence in aging through the prism of Koch-like criteria
Heat-induced extracellular HSP72 release is blunted in elderly diabetic people compared with healthy middle-aged and older adults, but it is partially restored by …
Drosophila as a Model to Study the Link between Metabolism and Cancer
Oxidative stress-mediated senescence in mesenchymal progenitor cells causes the loss of their fibro/adipogenic potential and abrogates myoblast fusion
Immune Senescence and Inflammaging in Neurological Diseases
Inflammaging and human longevity in the omics era
Role of sphingolipids in senescence: implication in aging and age-related diseases
Mitochondrial activity and dynamics changes regarding metabolism in ageing and obesity
Premature physiologic aging as a paradigm for understanding increased risk of adverse health across the lifespan of survivors of childhood cancer
The molecular intersection between senescence and major depression in the elderly
Senescent cells: a new Achilles’ heel to exploit for cancer medicine?
From cellular senescence to age-associated diseases: miRNAs as tools and targets for healthy ageing
Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model
Ripk3 regulates cardiac microvascular reperfusion injury: the role of IP3R-dependent calcium overload, XO-mediated oxidative stress and F-action/filopodia-based …
The dual role of cellular senescence in developing tumors and their response to cancer therapy
Identification of new genes associated to senescent and tumorigenic phenotypes in mesenchymal stem cells
Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing
Cellular senescence in osteoarthritis and anti-aging strategies
Downregulation of miR-130b~ 301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer
Hydrogen sulfide ameliorates aging-associated changes in the kidney
The peritoneal “soil” for a cancerous “seed”: a comprehensive review of the pathogenesis of intraperitoneal cancer metastases
Aging mechanisms and intervention targets
Inflammaging and ‘Garb-aging’
NLRP3 inflammasome activation in inflammaging
Mechanisms and functions of cellular senescence
The Effects of the Senescent Preadipocyte Secretome on Skeletal Muscle Cells
Ras signaling in aging and metabolic regulation
Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives
Anthracycline cardiotoxicity: looking for new therapeutic approaches targeting cell senescence?
Coenzyme Q10 prevents senescence and dysfunction caused by oxidative stress in vascular endothelial cells
Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function
Senescent cells and osteoarthritis: a painful connection
Oncogenic KRAS and the Inflammatory Micro-Environment in Pancreatic Cancer
Linking cellular stress responses to systemic homeostasis
Cellular senescence, senescence-associated secretory phenotype, and chronic kidney disease
With great age comes great metastatic ability: ovarian cancer and the appeal of the aging peritoneal microenvironment
Lipometabolism and Glycometabolism in Liver Diseases
A null mutation in SERPINE1 protects against biological aging in humans
CELLULAR STRESS RESPONSE GENES IN ALZHEIMER’S DISEASE: INSIGHTS FROM GENOME-WIDE ASSOCIATION STUDIES
Osteoarthritis Biology
Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis
Oxidative stress in mesenchymal stem cell senescence: regulation by coding and noncoding RNAs
Divergent mechanisms of metabolic dysfunction drive fibroblast and T-cell senescence
Is the secret for a successful aging to keep track of cancer pathways?
Acute genotoxic stress-induced senescence in human mesenchymal cells drives a unique composition of senescence messaging secretome (SMS)
HIF1α deletion facilitates adipose stem cells to repair renal fibrosis in diabetic mice
Deletion of Nrip1 Extends Female Mice Longevity, Increases Autophagy, and Delays Cell Senescence
Calcium signaling and cellular senescence
Stress, cell senescence and organismal ageing
Senescence as a novel mechanism involved in β-adrenergic receptor mediated cardiac hypertrophy
Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis
Secondary Unconjugated Bile Acids Induce Hepatic Stellate Cell Activation
MicroRNA regulation of oxidative stress-induced cellular senescence
Yields and chondrogenic potential of primary synovial mesenchymal stem cells are comparable between rheumatoid arthritis and osteoarthritis patients
The spectrum of fundamental basic science discoveries contributing to organismal aging
Seasonal variation in vitamin D in association with age, inflammatory cytokines, anthropometric parameters, and lifestyle factors in older adults
The imbalance between n-6/n-3 polyunsaturated fatty acids and inflammatory bowel disease: a comprehensive review and future therapeutic perspectives
Aging, inflammation and the environment
Rejuvenation of aged hematopoietic stem cells
Pathogenesis of wound healing disorders in the elderly
Microvesicles as potential biomarkers for the identification of senescence in human mesenchymal stem cells
Aging and the immune system: An overview
The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine
BBA-Molecular Basis of Disease
The impact of the Standard American Diet in rats: Effects on behavior, physiology and recovery from inflammatory injury
The macroH2A1. 1–PARP1 axis at the intersection between stress response and metabolism
Integrative Cardiovascular Physiology and Pathophysiology: Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and …
Circulating markers of ageing and allostatic load: A slow train coming
Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition
The Role of p16-Positive Senescent Cells in an Age-Related Disease and Aging Itself
Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironment
Autophagy and the cell biology of age-related disease
Using comparative biology to understand how aging affects mitochondrial metabolism
Maternal obesity impairs skeletal development in adult offspring
Cellular senescence links aging and diabetes in cardiovascular disease
Apelin/APJ system: A novel promising target for anti-aging intervention
The gut–liver axis and the intersection with the microbiome
Targeting senescent cells in fibrosis: pathology, paradox, and practical considerations
A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse
Mesenchymal stem cells secretory responses: senescence messaging secretome and immunomodulation perspective
Cell cycle and apoptosis regulator 2 at the interface between DNA damage response and cell physiology
Mechanisms of normal tissue injury from irradiation
Immunological aspects of age-related diseases
Happily (n) ever after: aging in the context of oxidative stress, proteostasis loss and cellular senescence
Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings
Senescence in health and disease
Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes
Emerging players at the intersection of chondrocyte loss of maturational arrest, oxidative stress, senescence and low-grade inflammation in osteoarthritis
Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing
Immunologic
Nutrient sensing pathways as therapeutic targets for healthy ageing
Articular cartilage aging-potential regenerative capacities of cell manipulation and stem cell therapy
Fibroblast activation and senescence in oral cancer
MicroRNAs and the metabolic hallmarks of aging
Genomic profiling and metabolic homeostasis in primary liver cancers
Mitochondria, oxidative stress and innate immunity
Human menstrual blood: a renewable and sustainable source of stem cells for regenerative medicine
Balancing between aging and cancer: molecular genetics meets traditional Chinese medicine
The mechanism of alopolysaccharide protecting ulceralive colitis
Glutathione peroxidase 3 delivered by hiPSC-MSCs ameliorated hepatic IR injury via inhibition of hepatic senescence
Novel strategies for anti-aging drug discovery
Cellular and molecular mechanisms of asthma and COPD
The role of kinase modulators in cellular senescence for use in cancer treatment
Inflammaging
Sex-specific differences in hypertension and associated cardiovascular disease
Comparison of several commonly used detection indicators of cell senescence
Loss of SATB1 Induces a p21 Dependent Cellular Senescence Phenotype in Dopaminergic Neurons
Effects of bioactive compounds on senescence and components of senescence associated secretory phenotypes in vitro
The integration of inflammaging in age-related diseases
Sphingolipids at the Crossroads of NAFLD and Senescence
Mitochondria, telomeres and cell senescence: implications for lung ageing and disease
SASP +adipose+tissue+&ots=A6ts81jdo4&sig=3CwomOd726aFBjPd4YNvvOWa1Uk” target=”_blank” rel=”noopener” data-saferedirecturl=”https://www.google.com/url?hl=en&q=https://books.google.com/books?hl%3Den%26lr%3Dlang_en%26id%3D3HCQDwAAQBAJ%26oi%3Dfnd%26pg%3DPA69%26dq%3DSASP %2Badipose%2Btissue%2B%26ots%3DA6ts81jdo4%26sig%3D3CwomOd726aFBjPd4YNvvOWa1Uk&source=gmail&ust=1579364469122000&usg=AFQjCNHEnnkq5JBN1ZAJuDAnchZTXr-Lbw”>Cellular Senescence and their Role in Liver Metabolism in Health and Disease: Overview and Future Directions
Mechanisms of dysfunction in the aging vasculature and role in age-related disease
Knockdown of IL-8 Provoked Premature Senescence of Placenta-Derived Mesenchymal Stem Cells
Treating Age-Related Diseases with Somatic Stem Cells
Controlling insulin resistance through modulation of interplay between mediators of cellular senescence: A mathematical study
Mechanisms of renal fibrosis
Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock …
Characterization of brusatol self-microemulsifying drug delivery system and its therapeutic effect against dextran sodium sulfate-induced ulcerative colitis in mice
Innate immunity and cellular senescence: The good and the bad in the developmental and aged brain
Stellate cells in tissue repair, inflammation, and cancer
YAP inhibits the apoptosis and migration of human rectal cancer cells via suppression of JNK-Drp1-mitochondrial fission-HtrA2/Omi pathways
DHA-enriched fish oil upregulates cyclin-dependent kinase inhibitor 2A (P16INK) expression and downregulates telomerase activity without modulating effects of …
Antioxidant and anti-senescence effect of metformin on mouse olfactory ensheathing cells (mOECs) may be associated with increased brain-derived neurotrophic …
Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype
Procancerogenic activity of senescent cells: A case of the peritoneal mesothelium
Key proteins and pathways that regulate lifespan
miRNAs in stem cell aging and age-related disease
Unhealthy Stem Cells: When Health Conditions Upset Stem Cell Properties
Cellular senescence and inflammaging in age-related diseases
Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts
Isolation and prolonged expansion of oral mesenchymal stem cells under clinical-grade, GMP-compliant conditions differentially affects “stemness” properties
Extracellular vesicles in the tumor microenvironment: therapeutic resistance, clinical biomarkers, and targeting strategies
Down-regulation of hepatic MBOAT7 by hyperinsulinemia favors steatosis development
The Impact of the Mediterranean Diet on Aging, Frailty, and Longevity
The epigenetics of inflammaging: The contribution of age-related heterochromatin loss and locus-specific remodelling and the modulation by environmental …
Program & Book of Abstracts: IUBMB Advanced School Nutrition, Metabolism and Aging 2018
Immune senescence: significance of the stromal microenvironment
Extracellular vesicles and aging
Senescence and cell death in chronic liver injury: roles and mechanisms underlying hepatocarcinogenesis
Energy to Fight Infection
Senescent, dysfunctional human cardiac progenitor cells (CPCs) accumulate in the aged heart and elimination of senescent cells enhances CPC activation and …
Cellular senescence, geroscience, cancer and beyond
Stem Cell Applications in Rejuvenation
Progeria and accelerated cardiovascular aging
Camellia Oil (Camellia oleifera Abel.) Modifies the Composition of Gut Microbiota and Alleviates Acetic Acid-Induced Colitis in Rats
Ionizing radiation-induced cellular senescence promotes tissue fibrosis after radiotherapy. A review
Major trauma and acceleration of the ageing process
Inflammatory bowel diseases: Current therapeutic approaches and potential of using stem cells
PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses
Obesity, Metabolism, and Aging: A Multiscalar Approach
PPARγ-activation increases intestinal M1 macrophages and mitigates formation of serrated adenomas in mutant KRAS mice
Current Approaches of Anti-inflammatory-Dependent Antiaging Strategies
Immunosenescence in neurocritical care
Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice
Cellular senescence: a view throughout organismal life
Effect of Mst1 on endometriosis apoptosis and migration: role of Drp1-related mitochondrial fission and parkin-required mitophagy
Ceramide synthase 4: a novel metabolic regulator of oncogene-induced senescence
Regulation and function of p53: A perspective from Drosophila studies
Relevance of the p53–MDM2 axis to aging
Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice
Exercise and bone health across the lifespan
Urothelial senescence in the pathophysiology of diabetic bladder dysfunction-a novel hypothesis
Gut microbiota’s relationship with liver disease and role in hepatoprotection by dietary natural products and probiotics
Developmental programming of aging trajectory
Senescent microvesicles: a novel advance in molecular mechanisms of atherosclerotic calcification
Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging
Disruptions in gut microbial-host co-metabolism and the development of metabolic disorders
In vivo effects of DNA lesions in Nucleotide Excision Repair deficient mice
Bone Research Society, Annual Meeting 2017 Proceedings
The clinical potential of senolytic drugs
Anti-senescence compounds: a potential nutraceutical approach to healthy aging
Loss of ovarian hormones and accelerated somatic and mental aging
Inflammation and premature aging in advanced chronic kidney disease
C. elegans eats its own intestine to make yolk leading to multiple senescent pathologies
Aging With HIV and Oxidative Stress
Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine
DICER1: a key player in rheumatoid arthritis, at the crossroads of cellular stress, innate immunity, and chronic inflammation in aging
miR-125a induces apoptosis, metabolism disorder and migrationimpairment in pancreatic cancer cells by targeting Mfn2-related mitochondrial fission
Biology of Aging
Cellular senescence in tissue repair: every cloud has a silver lining
Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis
Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures
Cellular senescence, neurological function, and redox state
Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expression
Mechanisms of vascular aging
Environmental and Physiological Cues on the Hypothalamus During Aging
Reaction time in healthy elderly is associated with chronic low-grade inflammation and advanced glycation end product
Phospholipase C delta 4 (PLCδ4) is a nuclear protein involved in cell proliferation and senescence in mesenchymal stromal stem cells
Epigenetics in cardiac fibrosis: emphasis on inflammation and fibroblast activation
Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells
PGC-1α protects RPE cells of the aging retina against oxidative stress-induced degeneration through the regulation of senescence and mitochondrial quality control …
Pro-resolving lipid mediators: Agents of anti-ageing?
Hyperglycaemia Stress-Induced Renal Injury is Caused by Extensive Mitochondrial Fragmentation, Attenuated MKP1 Signalling, and Activated JNK-CaMKII-Fis1 …
Energy restriction in renal protection
Targeting cancer stem cells and their niche: Perspectives for future therapeutic targets and strategies
Senescence-associated microRNAs
Cellular senescence and liver disease: Mechanisms and therapeutic strategies
Gene expression hallmarks of cellular ageing
Facing up to the global challenges of ageing
Melatonin and inflammation—Story of a double‐edged blade
The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process
Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption
In vivo and in vitro study on the efficacy of terpinen-4-ol in dextran sulfate sodium-induced mice experimental colitis
The emerging roles of microRNAs in stem cell aging
Bone marrow-derived mesenchymal stromal cells promote colorectal cancer cell death under low-dose irradiation
Umbilical cord–derived mesenchymal stromal cell–conditioned medium exerts in vitro antiaging effects in human fibroblasts
Tetraploidy in cancer and its possible link to aging
Senescent cells: a therapeutic target for cardiovascular disease
Non-Cell autonomous effects of the senescence-associated secretory phenotype in cancer therapy
The effect of green tea extract compounds on regulation of glucose homoeostasis in insulin-sensitive and breast cancer cells
Mammalian STE20-Like Kinase 1 Deletion Alleviates Renal Ischaemia-Reperfusion Injury via Modulating Mitophagy and the AMPK-YAP Signalling Pathway
Immunosenescence: the role of aging in the predisposition to neuro-infectious complications arising from the treatment of multiple sclerosis
SIPS as a model to study age-related changes in proteolysis and aggregate formation
Epithelial cell cycle behaviour in the injured kidney
Immunosenescence and Ageing in HIV
Long-term persistent organic pollutants exposure induced telomere dysfunction and senescence-associated secretary phenotype
Aging, Telomere Integrity, and Antioxidant Food
Advances in tendon mechanobiology
DICER1: a key player in rheumatoid arthritis, at the crossroads of cellular stress, innate immunity and chronic inflammation in ageing
G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes
NR4A1 contributes to high-fat associated endothelial dysfunction by promoting CaMKII-Parkin-mitophagy pathways
Age, gender and UV-exposition related effects on gene expression in in vivo aged short term cultivated human dermal fibroblasts
Role Of COX2 In Cellular Senescence
Tissue aging: the integration of collective and variant responses of cells to entropic forces over time
Counterregulatory Effects of Ptx3 on Inflammation and Cellular Aging
Resveratrol as an Activator or Inhibitor of Enzymes and Proteins
Induction of a senescence-like phenotype in cultured human fetal microglia during HIV-1 infection
Vitamin C, aging and Alzheimer’s disease
Screening and treating prostate cancer in the older patient: decision making across the clinical spectrum
Mechanisms driving the ageing heart
Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo
Biomedical Research in Aging
Modelling of mitochondrial metabolism in breast cancer
Age and age-related diseases: role of inflammation triggers and cytokines
Inducers of senescence, toxic compounds, and Senolytics: the multiple faces of Nrf2-activating phytochemicals in Cancer adjuvant therapy
Epidermal Growth Factor Therapy Impact on Scar Tissue Resilience of Diabetic Lower Limbs Ulcers-An Enlightening Hypothesis
The Impact of Membrane Phospholipid Composition and Extracellular Vesicles on the Immunoregulative Properties of Human Mesenchymal Stromal Cells
Autophagy regulation in preeclampsia: Pros and cons
The interplay between immunity and aging in Drosophila
Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions
Nitric Oxide Regulates H2O2-Induced Senescence via S-Nitrosylation of NF-κB in Endothelial Cells
Biliary bile acids in hepatobiliary injury–What is the link?
Cover ImageReport and Abstracts of the 14th Meeting of IIM, the Interuniversity Institute of Myology,-Assisi (Italy), October 12-15, 2017
Role of the inflammation-autophagy-senescence integrative network in osteoarthritis
Novel treatment strategies for chronic kidney disease: insights from the animal kingdom
Aging hallmarks: the benefits of physical exercise
mTORC inhibitors as broad-spectrum therapeutics for age-related diseases
Bioactive nutrients and nutrigenomics in age-related diseases
The nematode Caenorhabditis elegans as a model for aging research
Sleep health: reciprocal regulation of sleep and innate immunity
Osteoblast suppression in multiple myeloma bone disease
Yap regulates gastric cancer survival and migration via SIRT1/Mfn2/mitophagy
Hypoxia Prevents Mitochondrial Dysfunction and Senescence in Human Cardiac Progenitor Cells
Senolytika-současný stav
In vivo and in vitro study of pancreatic islets aging: impact of endothelial senescence and microparticles on islet function
Mechanisms of Obesity-related Hepatocarcinogensis
Identification of rare and common genetic variants associated with hepatocellular carcinoma in patients with nonalcoholic fatty liver disease: mechanisms and clinical …
Nutrient supply affects the mRNA expression profile of the porcine skeletal muscle
Application of kinase inhibitors for anti-aging intervention
Telomeres, aging and exercise: guilty by association?
Long noncoding RNAs and RNA-binding proteins in oxidative stress, cellular senescence, and age-related diseases
Effects of exercise on inflammatory, oxidative, and neurotrophic biomarkers on cognitively impaired individuals diagnosed with dementia or mild cognitive impairment …
DNA damage-induced inflammation and nuclear architecture
Hormonal modulation of ageing skin microstructure and mechanical properties
The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism
Prospects of Pharmacological Interventions to Organismal Aging
Induction, regulation and roles of neural adhesion molecule L1CAM in cellular senescence
Investigating senescence in cellular plasticity and tissue regeneration
DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age
Targeting mitochondria to counteract age-related cellular dysfunction
Attenuated Macrophage Infiltration in Glomeruli of Aged Mice Resulting in Ameliorated Kidney Injury in Nephrotoxic Serum Nephritis
Mechanisms of Action of Drugs for Treating Endothelial Dysfunction in Diabetes Mellitus
Nutrient supply affects the mRNA expression profile of the porcine skeletal muscle
Oncogenic roles of the PI3K/AKT/mTOR axis
Organ reserve, excess metabolic capacity, and aging
Studies of Novel Factors from Fetal Mesenchymal Stem Cell and Their Applications in Bone and Cartilage Repair
Secreted α-Klotho maintains cartilage tissue homeostasis by repressing NOS2 and ZIP8-MMP13 catabolic axis
Extracellular vesicles and their miRNA cargo in ageing and age-associated diseases
The Pathobiology of Osteoarthritis in Obesity: The Role of Synovial Inflammation, Joint Insulin Resistance, and Dysbiosis of the Gut Microbiome
Osteobiology of aging
PTEN enhances nasal epithelial cell resistance to TNFα‑induced inflammatory injury by limiting mitophagy via repression of the TLR4‑JNK‑Bnip3 pathway
Recent advances in understanding cross-talk between Bile Acids and Gut Microbiota. Open J Proteom Genom 3 (1): 024-034
Interleukin 1 gene polymorphism and susceptibility to disease
Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice
Patent Highlights February–March 2018
Microbiome and NAFLD: potential influence of aerobic fitness and lifestyle modification
Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging
Workshop on Synergies Between Alzheimer’s Research and Clinical Gerontology and Geriatrics: Current Status and Future Directions
WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation
A double-blind, randomized trial on the effect of a broad-spectrum dietary supplement on key biomarkers of cellular aging including inflammation, oxidative …
Innate and adaptive immunity in atherosclerosis
Functional interaction between melatonin signaling and noncoding RNAs
Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
Nicotinamide Phosphoribosyltransferase In Smooth Muscle Cells And Aortic Integrity
Analysis of Aortic Valve Function in the Absence of Endothelial Retinoblastoma Protein
Oxidative stress and the epigenetics of cell senescence: Insights from progeroid syndromes
The RNA world of human ageing
A system for the expression and release of heterologous proteins from the core of Bacillus subtilis spores
THE CANCER AND BONE SOCIETY (CABS) ANNUAL CONFERENCE
The versatile role of exosomes in cancer progression: diagnostic and therapeutic implications
Vascular aging: molecular mechanisms and potential treatments for vascular rejuvenation
The interplay between immunity and aging in Drosophila
Submission to the British Geriatrics Society Amulree Prize 2017
The cancer and bone society (CABS) annual conference Sheraton indianapolis hotel at keystone crossing. Indianapolis, Indiana. May 4-6, 2017
AAVvector-mediated in vivo reprogramming into pluripotency
Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood
Toll-like receptor-4 signaling pathway in aorta aging and diseases:“its double nature”
The Relevance of Induced Pluripotent Stem Cells for the Study of Physiological and Premature Aging
Turning Round: Optimizing the Anti-Inflammatory Properties of Equine Bone Marrow Derived Mesenchymal Stem Cells for Osteoarthritis Through Three-Dimensional …
Immunomodulatory properties and senescence-associated secretory phenotypes in human mesenchymal stem cell aging
Potency of Human Cardiosphere‐Derived Cells from Patients with Ischemic Heart Disease Is Associated with Robust Vascular Supportive Ability
Stem cells, scaffolds and small molecules for orthopedic tissue regeneration
Cardiac Effects of Antirheumatic Drugs
C. Elegans Eats Its Own Intestine to Make Yolk: A Cause of Senescent Polymorbidity
Senescence Induced by DNA Demethylating Drugs to Treat Solid Tumors
Autophagy-dependent gut-to-yolk biomass conversion generates visceral polymorbidity in aging C. elegans
Identification of Molecular Determinants of Cellular Senescence in Cancer and Aging
as a model for aging research
Old maids: aging and its impact on microglia function
Key Age-Imposed Signaling Changes That Are Responsible for the Decline of Stem Cell Function
The effect of metformin on absolute telomere length
The role of melatonin, a multitasking molecule, in retarding the processes of ageing
Chromatin architectural changes during cellular senescence and aging
Nuclear translocation of argonaute 2 in cytokine-induced senescence
Inflammation and CMV-associated lymphocyte senescence in chronic HIV infection
Length-independent telomere damage drives cardiomyocyte senescence
VRK1 phosphorylates Tip60 acetyltransferase and promotes its accumulation in response to both DNA damage and mitogens
Induced Cell Turnover: A Novel Therapeutic Modality for In Situ Tissue Regeneration
Induction de la sénescence endothéliale auriculaire par l’angiotensine II et la thrombine: rôle du stress oxydant et caractérisation du phénotype pro-thrombotique, pro …
Gestational chronodisruption leads to persistent changes in the rat fetal and adult adrenal clock and function
Induction of atrial endothelial senescence by angiotensin II and thrombin: role of oxidative stress and characterization of pro-thrombotic, pro-adhesive, proteolytic and …
Induction of iPS Cell Differentiation Into Connexin26 Positive Cells with Gap Junction Plaques and Characterization of Cochlear Feeder Cell
AGE-ASSOCIATED LAMIN-B1 REDUCTION IN THE THYMIC EPITHELIAL CELLS AND ITS ROLE IN THYMIC INVOLUTION
The role of epigenetics in renal ageing
Cancer and aging-the inflammatory connection
The role of melanocyte senescence in skin ageing
Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies
Regulation of the Pro-Tumorigenic Senescence-Associated Secretory Phenotype
LE POTENTIEL HEPATIQUE DES CELLULES SOUCHES MESENCHYMATEUSES RAJEUNNIES ET DES PROGENITEURS ENDODERMIQUES: CONTRIBUTION …
Different transcriptional profiling between senescent and non-senescent human coronary artery endothelial cells (HCAECs) by omeprazole and lansoprazole …
Adoptive autophagy activation: a much-needed remedy against chemical induced neurotoxicity/developmental neurotoxicity
Aging and Antiaging Strategies
Comparison of mesenchymal stem cells obtained by suspended culture of synovium from patients with rheumatoid arthritis and osteoarthritis
Antiretroviral Drug Mediated Astrocyte Senescence as a Contributor to HIV-1-Associated Neurocognitive Disorders
Senescent Cells Drive Frailty through Systemic Signals
Changes in the biochemical taste of cytoplasmic and cell-free DNA are major fuels for inflamm-aging
The association between back muscle characteristics and pressure pain sensitivity in low back pain patients
Role of pattern recognition receptors of the neurovascular unit in inflamm-aging
Hepatic potential of Reversed-age Mesenchymal Stem Cells and Endodermal Progenitors: Contribution of LGR5 and Cdc42 cell signaling pathways
Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis
Synthetic lethal treatment strategies for tumor cell senescence
ISEV2018 abstract book
Aging, Cellular Senescence, and Kidney Fibrosis
Sex hormones and immunosenescence
Telomerase may paradoxically accelerate aging of the DNA methylome
CD36 initiates the secretory phenotype during the establishment of cellular senescence
A novel in vitro macrophage senescence model to study macrophaging
A novel in vitro macrophage senescence model to study macrophaging
Ageing Astrocytes-Implications for Motoneuron Dysfunction and Sarcopenia
BMP-7: role and regulation in osteoarthritis
Aging and Malignant Hemopathies: A Complex Multistep Process
Biomarkers for Identification of the Dormancy Phenotypes Senescence and Quiescence in Malignancy
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) and liver fibrosis: A review
Modulating Ageing Anti-Ageing
An in vivo and in vitro study of stress-induced senescence in neurones and its role in neurodegeneration
Gene Expression, Epigenetics and Ageing
German Congress of Laboratory Medicine: 15th Annual Congress of the DGKL (German Society of Clinical Chemistry and Laboratory Medicine) and the 3rd …
Aging Mouse Models Reveal Complex Tumor-Microenvironment Interactions in Cancer Progression
The role of neutrophils in telomere induced senescence via bystander effects
MITOCHONDRIAL STRESS COMMUNICATION IN MAMMALIAN CELLS
GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging
Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP -associated signals, in cellular senescence and aging
Exosome-based immunomodulation during aging: a nano-perspective on inflamm-aging
Leukocyte count, systemic inflammation, and health status in older adults: a narrative review
Two Conserved Histone H3 Lys9 Demethalases KDM3A and KDM4C Regulate MSCs Senescence Progress
Nutrient Sensing, Signaling and Ageing: The Role of IGF-1 and mTOR in Ageing and Age-Related Disease
Identification of HSP90 inhibitors as a novel class of senolytics
Aging of the Bone
Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease
PREMATURE IMMUNOSENESCENCE IN WOMEN NEWLY DIAGNOSED WITH BREAST CANCER–ROLE OF EARLY-LIFE STRESS
Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2
Sex and the Aging Immune System
Molecular pathology: the roles of P53 in the oxidative stress and DNA damage responses in chronic liver disease and hepatocellular carcinoma
A Computational System for Automated Meta-Analysis of Gene Expression Data
Modulating Aged Macrophages and Osteoprogenitors with a Calcium Phosphate Drug Delivery System
Examining Autophagy and Mitophagy as Inducible Mechanisms of Cellular Remodelling
Proteotoxicity links therapy-induced cancer cell senescence to Alzheimer’s disease
Macrophages in M1/M2 states and exposed to amyloid-beta: a RNA-seq analysis in human cells
Atorvastatin inhibits inflammatory response, attenuates lipid deposition, and improves the stability of vulnerable atherosclerotic plaques by modulating …
Werner Syndrome as a Model of Human Aging
Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging
Cytokine profile of breast cell lines after different radiation doses
Exercise and circulating factors associated with skeletal muscle and bone health in older age
Microbiota, NASH, HCC and the potential role of probiotics
Autophagy and Signaling
β-Hydroxybutyrate prevents vascular senescence through hnRNP A1-mediated upregulation of Oct4
Sarcopenia: aging-related loss of muscle mass and function
Zinc finger protein ZFP36L1 promotes osteoblastic differentiation but represses adipogenic differentiation of mouse multipotent cells
Elucidating the role of metabolic changes in modulating cell fate following treatment with anti-mitotic drugs
TGF-β signaling accelerates senescence of human bone-derived CD271 and SSEA-4 double-positive mesenchymal stromal cells
Progenitor cells from the adult heart
A rising star in pancreatic diseases: pancreatic stellate cells
Secretome analysis of testicular peritubular cells as a clue for solving the puzzle of the human spermatogonial stem cell niche
Functional Identification of MicroRNAs Counteracting Cellular Senescence
The Geriatrician’s Perspective on Surgery in the Geriatric Population
Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis
The Long Noncoding RNA H19 Controls Endothelial Cell Functions by STAT3 Repression
Clinical Implications for Mitochondrial Stress Induced Senescence and Potential Interventions S
The effects of aging in the hippocampus and cognitive decline
Human Cytomegalovirus as a driving force towards Immunosenescence
Hematopoietic Stem Cell Aging and Malignant Hemopathies
Role of Autophagy in Liver Regeneration
Old age causes de novo intracortical bone remodeling and porosity in mice
Aging Kidney and Aging-Related Disease
Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells
Senescence-associated IL-6 and IL-8 cytokines induce a self-and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in …
Model of Chaperones in Aging
Senescent Cells Differentially Translate Senescence-Related mRNAs Via Ribosome Heterogeneity
Accumulation of prelamin A drives inflammation in the heart with implications for treatment of inherited and acquired cardiomyopathies
Senescence in COPD and its comorbidities
Characterizing Senescence in Astrocytes and its Effect on Neurons
Barshop Symposium on Aging 2017 Abstracts
Role of vascular smooth muscle cell derived-exosomes in age-related vascular amyloidosis
Cancer metabolism in space and time: beyond the Warburg effect
Melatonin protected cardiac microvascular endothelial cells against oxidative stress injury via suppression of IP3R-[Ca2+]c/VDAC-[Ca2+]m axis by activation of …
Tumor Microenvironment, Therapeutic Resistance, and Personalized Medicine
Liver regeneration in aged mice: new insights
In medio stat virtus: unanticipated consequences of telomere dysequilibrium
The contribution of oxidative stress and inflamm-aging in human and equine asthma
NR4A1 promotes diabetic nephropathy by activating mff-mediated mitochondrial fission and suppressing parkin-mediated mitophagy
DNA damage induced by Strontium-90 exposure at low concentrations in mesenchymal stromal cells: the functional consequences
Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
Role of primary cilia in non-dividing and post-mitotic cells
The role of cancer-associated fibroblasts and fibrosis in liver cancer
Reversibility of chemotherapy-induced senescence is independent of autophagy and a potential model for tumor dormancy and cancer recurrence.
Cancer Cells Exploit Notch Signaling To Redefine A Tumor Supportive Cytokine Milieu
Programmed cell senescence in skeleton during late puberty
Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect
SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy
Psychological stress and mitochondria: a conceptual framework
Immunosenescence and hurdles in the clinical management of older HIV-patients
Stress granules counteract senescence by sequestration of PAI‐1
The power behind the throne: senescence and the hallmarks of cancer
The exercise and diet-microbiome paradigm: influences of physical activity and dietary nutrition on the human gut microbiome
Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission
The functions and regulation of the PTEN tumour suppressor: new modes and prospects
Distribution and molecular characterization of South African Bacillus Anthracis strains and their associated bacteriophages
TARGETING ASCT2/SLC1A5 FOR INHIBITION OF CELLULAR GROWTH AND METABOLISM IN TRIPLE-NEGATIVE BREAST CANCER
Cellular Senescence and Inflammaging in Age-Related Diseases
The gut microbiome and liver cancer: mechanisms and clinical translation
BBA-Reviews on Cancer
RNA Binding Proteins, Ageing and Caloric Restriction
Controlling senescence by PML and PML nuclear bodies
Ataxia telangiectasia syndrome: moonlighting ATM
ER stress and impaired autophagy flux in neuronal degeneration and brain injury
Leukotriene D4 induces cellular senescence in osteoblasts
Understanding the Basis of Gene Regulation of Common Complex Diseases by Computational Analysis of Next-generation Sequencing Data
Matrix stiffness regulates oxidative stress response of human dermal fibroblasts
Inflammation and the Gut-Liver Axis in the Pathophysiology of Cholangiopathies
Dendritic Polyglycerol Sulfate Hydrogels as a Potential Viscosupplement for Treatment of Osteoarthritis
Bile acids and cancer: direct and environmental-dependent effects
INVOSSATM–a cell and gene therapy for osteoarthritis
In vitro proinflammatory gene expression predicts in vivo telomere shortening: A preliminary study
Enhancer function driving cellular senescence, DNA damage repair, differentiation, and nuclear organization
Investigating strategies to boost cutaneous varicella zoster virus-specific immune responses in ageing humans
Natural variations in yeast aging reveal genetic and environmental factors
Circulating levels of soluble Receptor for Advanced Glycation End-products (sRAGE) decrease with aging and may predict age-related cardiac remodeling
Age-associated metabolic reprogramming, oxidative stress response, and cancer progression
Impact of age-associated estrogen deficiency on innate immune responses to myocardial ischemic injury in the female rat heart
Antioxidant and oxidative stress: A mutual interplay in age-related diseases
MicroRNAs deregulation in prostate cancer
Vaccination in the elderly: The challenge of immune changes with aging
From rapalogs to anti-aging formula
Biomarkers of monitoring and functional reserve of physiological systems over time in HIV: expert opinions for effective secondary prevention
IDENTIFICATION OF INTRINSIC REGULATORS IN NORMAL AND MALIGNANT HUMAN HEMATOPOIESIS
Epigenome-wide DNA methylation and mitochondrial DNA content in relation to in utero PM2.5 exposure
l-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway
adipose tissue , aging, and metabolism
Growth hormone impact on adipose tissue and aging
adipose tissue Quality in Aging: How Structural and Functional Aspects of adipose tissue Impact Skeletal Muscle Quality
Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
adipose tissue : A Tertiary Lymphoid Organ: Does It Change with Age?
Age-Dependent and-Independent Effects of Perivascular adipose tissue and Its Paracrine Activities during Neointima Formation
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia
Heparanase upregulation from adipocyte associates with inflammation and endothelial injury in diabetic condition
Cellular senescence: at the nexus between ageing and diabetes
OBESITY INDUCES MESENCHYMAL STEM CELL SENESCENCE AND DYSFUNCTION
Histologic analysis and lipid profiling reveal reproductive age-associated changes in peri-ovarian adipose tissue
In vitro model of chronological aging of adipocytes: Interrelationships with hypoxia and oxidation
Sympathetic nervous system as a target for aging and obesity-related cardiovascular diseases
Senescent cells in the development of cardiometabolic disease
Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression
Relationship between Circulating Protein p53 and High Sensitivity C-Reactive Protein in Central Obesity Men with Inflammaging
Extracellular fraction of adipose tissue as an innovative regenerative approach for vitiligo treatment
Normal breast tissue at risk for cancer development: A breast cancer initiating role for mammary adipocytes
Age-associated inflammation alters the aging trajectory
Life-span Extension Drug Interventions Affect adipose tissue Inflammation in Aging
Cellular senescence and senescence‐associated T cells as a potential therapeutic target
Mitochondrial Uncoupling Protein-2 Is a Putative Link Between Mitochondrial Dysfunction and Fibroblast Senescence in Age-Related Lung Fibrosis
Lipotoxicity, aging, and muscle contractility: does fiber type matter?
Skeletal muscle as potential central link between sarcopenia and immune senescence
Ileal Transposition Increases Pancreatic β Cell Mass and Decreases β Cell Senescence in Diet-Induced Obese Rats
ALCAT1 Deficiency Attenuates Obesity Induced Cellular Senescence in P16-3MR Transgenic Mice
Short exposure to cold atmospheric plasma induces senescence in human skin fibroblasts and adipose mesenchymal stromal cells
Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer
Alteration of Hypoxia-Associated Gene Expression in Replicatively Senescent Mesenchymal Stromal Cells under Physiological Oxygen Level
Rejuvenating Strategies of Tissue-specific Stem Cells for Healthy Aging
Novel contributors and mechanisms of cellular senescence in hypertension-associated premature vascular aging
β Cell Senescence as a Common Contributor to Type 1 and Type 2 Diabetes
Obesity and cancer: A mechanistic overview of metabolic changes in obesity that impact genetic instability
Age-dependent impairment of adipose-derived stem cells isolated from horses
Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?
Therapeutic Irradiation: Consequences for Bone and Bone Marrow Adipose
The Role of the Gut Microbiome and its Derived Mediators in Nonalcoholic Fatty Liver Disease
Inflamm-Aging Is Associated with Lower Plasma PTX3 Concentrations and an Impaired Capacity of PBMCs to Express hTERT following LPS Stimulation
Impaired immunomodulatory ability of type 2 diabetic adipose-derived mesenchymal stem cells in regulation of inflammatory condition in mixed leukocyte …
3D printing breast tissue models: A review of past work and directions for future work
Aged‐senescent cells contribute to impaired heart regeneration
Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL
Senescent cells: A new Achilles’ heel to exploit for cancer medicine?
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline
Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing
The burden of metabolic syndrome on osteoarthritic joints
Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis
Remodeling the Microenvironment before Occurrence and Metastasis of Cancer
Immune senescence and cardiomyopathy associated with obesity
The role of cellular senescence in diabetes mellitus and osteoporosis: molecular pathways and potential interventions
Filamin B and CD13 Are Components of Senescent Secretomes That May Be Involved in Primary (Stress Induced) and Paracrine Senescence of Mesenchymal …
and Ahmet Turan Isik
β‐Cell senescence in the pathogenesis of type 2 diabetes
Inflammation, Frailty and Cardiovascular Disease
Cellular Senescence in the Kidney
Heat shock response to exercise in pancreatic islets of obese mice
Regulation of senescence and the SASP
The Links Between Osteoporosis and Sarcopenia in Women
Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin
Type 2 diabetes is associated with the accumulation of senescent T cells
Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in mice
Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ pro-inflammatory macrophages
Adipokines: New Therapeutic Target for Osteoarthritis?
Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults
Expansion and cell-cycle arrest: Common denominators of cellular senescence
Mechanisms of obesity-induced metabolic and vascular dysfunctions
Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept
Mixing old and young: enhancing rejuvenation and accelerating aging
Involvement of adiponectin in age-related increases in tear production in mice
LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis
Emerging roles of and therapeutic strategies targeting BRD4 in cancer
In situ evidence of cellular senescence in Thymic Epithelial Cells (TECs) during human thymic involution
Cellular senescence in bone
Effect of aging on behaviour of mesenchymal stem cells
Earlier changes in mice after D-galactose treatment were improved by mitochondria derived small peptide MOTS-c
Pleiotropic effect of fibrates on senescence and autophagy in osteoarthritis
Low-dose quercetin positively regulates mouse healthspan
Microbial metabolites in non-alcoholic fatty liver disease
Elevated Local Senescence in Diabetic Wound Healing Is Linked to Pathological Repair via CXCR2
The potential role of senescence in limiting fibrosis caused by aging
Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?
Protective role of polyphenols against vascular inflammation, aging and cardiovascular disease
TGF-β Signaling in Cellular Senescence and Aging-Related Pathology
Obesity-induced cellular senescence drives anxiety and impairs neurogenesis
Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells
Targeting normal and cancer senescent cells as a strategy of senotherapy
Senescent and apoptotic osteocytes and aging: Exercise to the rescue?
Senotherapeutics: Emerging strategy for healthy aging and age-related disease
Extracellular vesicles circulating in young organisms promote healthy longevity
Effectiveness of stage by stage bariatric interventions for regression of comorbidity at obese class III patients
L1 drives IFN in senescent cells and promotes age-associated inflammation
The STATus of STAT3 in Lung Cell Senescence?
Intraarticular senescent chondrocytes impair the cartilage regeneration capacity of mesenchymal stem cells
Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix‐related gene expression partly via secretion of complement factor D
Mitochondria and cellular senescence: Implications for musculoskeletal ageing
Age and Frailty as Risk Factors for the Development of Osteoarthritis
The biology of frailty in humans and animals: Understanding frailty and promoting translation
Turning back time with emerging rejuvenation strategies
Senescence and senotherapeutics: A new field in cancer therapy
Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy
The Safe and Efficacious Use of Secretome From Fibroblasts and Adipose-derived (but not Bone Marrow-derived) Mesenchymal Stem Cells for Skin …
Cellular Senescence and the Immune System in Cancer
Advanced liver steatosis accompanies an increase in hepatic inflammation, colonic, secondary bile acids and Lactobacillaceae/Lachnospiraceae bacteria in C57BL/6 …
KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops
Chronic inflammation in the etiology of disease across the life span
Pan-senescence transcriptome analysis identified RRAD as a marker and negative regulator of cellular senescence
Flavonoids: Broad Spectrum Agents on Chronic Inflammation
Astrocyte senescence in an Alzheimer’s disease mouse model is mediated by TGF-β1 and results in neurotoxicity
mTOR as a central regulator of lifespan and aging
Vascular Diseases and Gangliosides
Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells
Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells
Looking for immortality: Review of phytotherapy for stem cell senescence
Gangliosides Contribute to Vascular Insulin Resistance
Emerging senolytic agents derived from natural products
Vitamin E: Regulatory Role on Signal Transduction
Experimental strategies of mesenchymal stem cell propagation: Adverse events and potential risk of functional changes
Introductory Chapter: Nonalcoholic Fatty Liver Disease-What Should We Know?
The role of probiotics in nonalcoholic fatty liver disease: a new insight into therapeutic strategies
Cellular senescence and chronological age in various human tissues: A systematic review and meta‐analysis
Nrf2 exerts mixed inflammation and glucose metabolism regulatory effects on murine RAW264. 7 macrophages
Chronic Low-grade Inflammatory Phenotype (CLIP) and Senescent Immune Dysregulation
Obesity May Accelerate the Aging Process
Manufacturing of primed mesenchymal stromal cells for therapy
Pyrroloquinoline quinone prevents estrogen deficiency-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence
Obesity is a common soil for premature cardiac aging and heart diseases-role of autophagy
Culinary medicine: advancing a framework for healthier eating to improve chronic disease management and prevention
Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development
Senescence in the lung: is this getting old?
TGF-β mediates aortic smooth muscle cell senescence in Marfan syndrome
Cellular senescence in cardiac diseases
Bone marrow niches for skeletal progenitor cells and their inhabitants in health and disease
Potential role of senescence in radiation-induced damage of the aged skeleton
The kynurenine pathway: a finger in every pie
Cell aging and cellular senescence in skin aging—Recent advances in fibroblast and keratinocyte biology
The Senescent Cell, SC
Mitochondria-driven elimination of cancer and senescent cells
Use of MSCs in Antiaging Strategies
Dynamic role of the codon 72 p53 single-nucleotide polymorphism in mammary tumorigenesis in a humanized mouse model
Promotion and induction of liver cancer by gut microbiome-mediated modulation of bile acids
Cellular cross-talks in the diseased and aging heart
Conditioned Medium of Mesenchymal Stromal Cells: A New Class of Therapeutics
Coexisting frailty with heart failure
Barshop Symposium on Aging 2018 Abstracts
Amitosenescence and Pseudomitosenescence: Putative New Players in the Aging Process
HIF1α‐mediated AIMP3 suppression delays stem cell aging via the induction of autophagy
Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis
Inflammation: a common contributor to cancer, aging, and cardiovascular diseases—expanding the concept of cardio-oncology
Inflammation as a mediator of arterial ageing
LINE-1 derepression in senescent cells triggers interferon and inflammaging
Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence
Early vascular ageing and cellular senescence in chronic kidney disease
Childhood obesity and leucocyte telomere length
Cell-Free Culture Supernatant of Probiotic Lactobacillus fermentum Protects Against H2O2-Induced Premature Senescence by Suppressing ROS-Akt-mTOR Axis in …
Raman fingerprints as promising markers of cellular senescence and aging
Where Metabolism Meets Senescence: Focus on Endothelial Cells
Exercise Training for the Elderly: Inflammaging and the Central Role for HSP70
Proteomic analysis of human mesenchymal stromal cell secretomes: a systematic comparison of the angiogenic potential
BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome
Quantifying Senescence-Associated Phenotypes in Primary Multipotent Mesenchymal Stromal Cell Cultures
Roles of JAK2 in aging, inflammation, hematopoiesis and malignant transformation
Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans
Cellular senescence in arterial diseases
25-Hydroxyvitamin D3 positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice
Inflammation, Infection and Atherosclerosis
Obesity-Associated Hypermetabolism and Accelerated Senescence of Bone Marrow Stromal Stem Cells Suggest a Potential Mechanism for Bone Fragility
Chronic whole-body heat treatment relieves atherosclerotic lesions, cardiovascular and metabolic abnormalities, and enhances survival time restoring the anti …
The chemistry of senescence
Stem Cell Senescence: the Obstacle of the Treatment of Degenerative Disk Disease
Autophagy Dysfunction, Cellular Senescence, and Abnormal Immune-Inflammatory Responses in AMD: From Mechanisms to Therapeutic Potential
Breast tissue biology expands the possibilities for prevention of age-related breast cancers
Senescent cell clearance by the immune system: Emerging therapeutic opportunities
Metformin and Aging: A Review
Non-Alcoholic Fatty Liver Disease, and the Underlying Altered Fatty Acid Metabolism, Reveals Brain Hypoperfusion and Contributes to the Cognitive Decline in APP …
Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells
Muscle and Bone Biology–Similarities and Differences
COPD as a Disease of Immunosenescence
Sex hormones and anticancer immunity
Targeting chronic innate inflammatory pathways, the main road to prevention of osteoarthritis progression
Autofluorescence is a Reliable in vitro Marker of Cellular Senescence in Human Mesenchymal Stromal Cells
Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide
Identification of Aberrantly Expressed Genes during Aging in Rat Nucleus Pulposus Cells
Role of the Gut–Liver Axis in Liver Inflammation, Fibrosis, and Cancer: A Special Focus on the Gut Microbiota Relationship
Type 2 diabetes: how much of an autoimmune disease?
Urine-Derived Stem Cells Secreting Small Extracellular Vesicles Loaded in Acellular Amniotic Membrane for Wound Healing Promotion in Aged Mice
Type 2 Diabetes: How Much of an Autoimmune Disease?
Fasting and rapamycin: diabetes versus benevolent glucose intolerance
Roles of the Immune System in the Development and Progression of Hepatocellular Carcinoma
Genetic Stability of Mesenchymal Stromal Cells for Regenerative Medicine Applications: A Fundamental Biosafety Aspect
Regulation of cellular senescence by retinoid X receptors and their partners
Secretome of Mesenchymal Stem Cells and its Impact on Chronic Obstructive Pulmonary Disease
Defective induction of the proteasome associated with T‐cell receptor signaling underlies T‐cell senescence
Lifestyle and Food Habits Impact on Chronic Diseases: Roles of PPARs
When the skin is in the center of interest-An aging issue
New frontiers in osteoporosis therapy
Aging and Cardiovascular Diseases: The Role of Cellular Senescence
Oxidative Stress and Non-Alcoholic Fatty Liver Disease: Effects of Omega-3 Fatty Acid Supplementation
Efficacy of 3D Culture Priming is Maintained in Human Mesenchymal Stem Cells after Extensive Expansion of the Cells
Potential Mechanisms of 3, 4-Oxo-Isopropylidene-Shikimic Acid in Ameliorating 2, 4, 6-Trinitrobenzenesulfonic Acid-Induced Colitis in Rats
Principal Criteria for Evaluating the Quality, Safety and Efficacy of hMSC-Based Products in Clinical Practice: Current Approaches and Challenges
The clinical impact and biological mechanisms of skeletal muscle aging
Chronic Kidney Disease and the Vascular Endothelium
Current Knowledge and New Challenges in Exercise Immunology
Aspirin ameliorates the long‐term adverse effects of doxorubicin through suppression of cellular senescence
Aging, Immunity, and Neuroinflammation: The Modulatory Potential of Nutrition
Perspectives of the International Society of Cell & Gene Therapy Gastrointestinal Scientific Committee on the Intravenous Use of Mesenchymal Stromal Cells in …
Cellular senescence: aging, cancer, and injury
Searching for the Holy Grail Will Need Biomarkers
DNA damage response manages cell cycle restriction of senile multipotent mesenchymal stromal cells
The role of mitochondria-derived peptides in cardiovascular disease: Recent updates
Tackling Aging by Using miRNA as a Target and a Tool
Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2
Premature aging and cancer development in transgenic mice lacking functional CYLD
Obesity-Induced Sympathoexcitation is Associated with Nrf2 Dysfunction in the Rostral VentroLateral Medulla
Senescence‐induced immunophenotype, gene expression and electrophysiology changes in human amniocytes
The senescence-associated secretory phenotype and its regulation
An early‐senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a …
Extracellular vesicles and redox modulation in aging
Survival of aging CD264+ and CD264− populations of human bone marrow mesenchymal stem cells is independent of colony‐forming efficiency
Seno-suppressive molecules as new therapeutic perspectives in rheumatic diseases
Identification of senescent cells in multipotent mesenchymal stromal cell cultures: current methods and future directions
The ING1a model of rapid cell senescence
The key players of tumor microenvironment and their role in breast cancer
Skin barrier immunity and ageing
Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species
Metabolic requirements of human pro-inflammatory B cells in aging and obesity
Aging and bone
Control of Inflammation by Calorie Restriction Mimetics: On the Crossroad of Autophagy and Mitochondria
PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state
Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming☆
The Molecular Physiology of Ageing: New Targets for Regenerative Medicine
Knockdown of angiopoietin-like 2 induces clearance of vascular endothelial senescent cells by apoptosis, promotes endothelial repair and slows …
Obesity and Hepatocarcinogenesis
Lifestyle Choices, Psychological Stress and Their Impact on Ageing: The Role of Telomeres
Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction
Exosomes may be the potential new direction of research in osteoarthritis management
Mitochondrial protection partly mitigates kidney cellular senescence in swine atherosclerotic renal artery stenosis
Molecular insights into Hutchinson-Gilford progeria syndrome and age-associated disease: from mechanisms to treatment strategy
Rapid detection of senescent mesenchymal stromal cells by a fluorescent probe
Iron and iron-dependent reactive oxygen species in the regulation of macrophages and fibroblasts in non-healing chronic wounds
Low‐Dose Pesticide Mixture Induces Accelerated Mesenchymal Stem Cell Aging In Vitro
Maternal Sleep in Pregnancy and Postpartum Part II: Biomechanisms and Intervention Strategies
Hydroxyurea‐induced Senescent Peripheral Blood Mesenchymal Stromal Cells Inhibit Bystander Cell Proliferation of JAK2V617F‐positive Human Erythroleukemia …
Doxorubicin and liposomal doxorubicin induce senescence by enhancing nuclear factor kappa B and mitochondrial membrane potential
The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem …
Myeloid-derived suppressor cells: not only in tumor immunity
Moderate hyperoxia induces senescence in developing human lung fibroblasts
Senolytics and senostatics as adjuvant tumour therapy
The link between endometrial stromal cell senescence and decidualization in female fertility: the art of balance
Melatonin attenuates renal fibrosis in diabetic mice by activating the AMPK/PGC1α signaling pathway and rescuing mitochondrial function
Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development: biochemical markers associated with emerging clinical …
Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway …
Regulation of inflammation as an anti‐aging intervention
Aiding and Abetting: How the Tumor Microenvironment Protects Cancer from Chemotherapy
Relationships between ion channels, mitochondrial functions and inflammation in human aging
Targeting senescent cells in translational medicine
Recent insights into the multiple pathways driving nonalcoholic steatohepatitis-derived hepatocellular carcinoma
Aging, sex, inflammation, frailty, and CMV and HIV Infections
Low-grade inflammation causes gap junction-coupled cell dysfunction throughout the body, which can lead to the spread of systemic inflammation
The upregulation of Toll-like receptor 3 via autocrine IFN-beta signaling drives the senescence of human mesenchymal stem cells through JAK1
Pak2 kinase promotes cellular senescence and organismal aging
Molecular Pathogenesis of Oral Submucous Fibrosis: A Critical Appraisal
Mechanisms of aging and potential role of selected polyphenols in extending healthspan
The role of lipids in aging-related metabolic changes
Emerging Role of Stem cell-derived Extravesicular MicroRNAs in Age-associated Human Diseases and in Different Therapies of Longevity
The genetics of human ageing
Inflammation in osteoarthritis: is it time to dampen the alarm (in) in this debilitating disease?
Estrogen deprivation triggers an immunosuppressive phenotype in breast cancer cells
Liver and Steroid Hormones—Can a Touch of p53 Make a Difference?
Impacts of the late adulthood diet-induced obesity onset on behavior, immune function, redox state and life span of male and female mice
The Mediterranean Diet Slows Down the Progression of Aging and Helps to Prevent the Onset of Frailty: A Narrative Review
Exosome: Advanced Development and a Novel Therapeutic Strategy for Osteoarthritis and Cartilage Injury
Diabetes drugs in the fight against Alzheimer’s disease
Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies
The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective
Immune Modulation by Transplanted Calcium Phosphate Biomaterials and Human Mesenchymal Stromal Cells in Bone Regeneration
Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells
Roles of sleep deprivation in cardiovascular dysfunctions
micro (RNA)-managing muscle wasting
Stem cell derived exosomes: microRNA therapy for age-related musculoskeletal disorders
Astrocyte senescence: Evidence and significance
FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics
Aging and the Biological Response to Liver Injury
Age-Related Thymic Atrophy: Mechanisms and Outcomes
The Effects of Early-Life Drug and Dietary Interventions on Late-Life Disease Development
Preclinical Evidence for the Role of Stem/Stromal Cells in COPD
Melatonin attenuates myocardial ischemia‐reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK‐OPA1 signaling pathways
Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du Decoction on ulcerative colitis and its regulation on intestinal flora in colitis mice
Future Cell and Gene Therapy for Osteoarthritis (OA): Potential for Using Mammalian Protein Production Platforms, Irradiated and Transfected Protein …
Gut microbiota in liver disease: too much is harmful, nothing at all is not helpful either
Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells
Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment
Pharmacology of metformin–An update
Restoring mechano-adaptation in aged murine bone
Slowing Down Ageing: The Role of Nutrients and Microbiota in Modulation of the Epigenome
Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells
Mechanistic complexities of bone loss in Alzheimer’s disease: a review
Investigation on Spectrum-Effect Correlation between Constituents Absorbed into Blood and Bioactivities of Baizhu Shaoyao San before and after Processing on …
Lifelong aerobic exercise protects against inflammaging and cancer
Distinct effects of epirubicin, cisplatin and cyclophosphamide on ovarian somatic cells of prepuberal ovaries
The Emerging Role of Exosomal Non-coding RNAs in Musculoskeletal Diseases
Mitochondria in the signaling pathways that control longevity and health span
Crosstalk between P53 and DNA Damage Response in Ageing
Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy
Dual faced HMGB1 plays multiple roles in cardiomyocyte senescence and cardiac inflammatory injury
Melatonin and chromatin
Mst1 facilitates hyperglycemia-induced retinal pigmented epithelial cell apoptosis by evoking mitochondrial stress and activating the Smad2 signaling pathway
Circular RNA CircCCNB1 sponges micro RNA-449a to inhibit cellular senescence by targeting CCNE2
Failure of immunosurveillance accelerates aging
Rationally-based therapeutic disease modification in systemic sclerosis: Novel strategies
Extracellular vesicles in human skin: cross-talk from senescent fibroblasts to keratinocytes by miRNAs
Pharmacodynamics OF TNF α inhibitors for the treatment of psoriasis
Integrated Theories of Biological Aging
Organismal Aging and Oxidants Beyond Macromolecules Damage<? Qry msg=” Please provide author biographies for up to three authors (each biography not …
The Role of Curcumin in the Modulation of Ageing
The Impending Epidemic of Cardiovascular Diseases in Patients With Cancer in Japan
Pro-and anti-tumorigenic functions of the senescence-associated secretory phenotype
Silencing of long noncoding RNA HOXA11-AS inhibits the Wnt signaling pathway via the upregulation of HOXA11 and thereby inhibits the proliferation …
Novel clinico-molecular insights into the role of bisphenol-A (BPA) in the etiology of diabetes
Mitochondria and aging—The role of exercise as a countermeasure
A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo
INJURY SENESCENCE OF THE IMMUNE SYSTEM
Directed elimination of senescent cells attenuates development of osteoarthritis by inhibition of c-IAP and XIAP
Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons
Moving beyond the current limits of data analysis in longevity and healthy lifespan studies
Cellular senescence and the kidney: potential therapeutic targets and tools
The Biology of Senescence
The clock is ticking: the impact of ageing on T cell metabolism
Ribosomal DNA instability: an evolutionary conserved fuel for inflammaging
Role of microRNA-141 in the aging musculoskeletal system: a current overview
Activation of immunosuppressive network in the aging process
Senescence cell–associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers
Molecular biology of acute and chronic inflammation
Transcriptomic analysis reveals the mechanism of sulfasalazine-induced liver injury in mice
Inflammatory bone marrow microenvironment
Cell and Gene Therapy for Spine Regeneration: Mammalian Protein Production Platforms for Overproduction of Therapeutic Proteins and Growth Factors
Interleukin-17 and senescence regulate the foreign body response
Nuclear-encoded Mitochondrial Genetic Variation in Human Aging and Longevity
Transient introduction of human telomerase mRNA improves hallmarks of progeria cells
DNA Damage Induced Cell Fates during Aging
Chromosomal instability and pro-inflammatory response in aging
Understanding the role of chondrocytes in osteoarthritis: utilizing proteomics
Emerging Roles of Complement Protein C1q in Neurodegeneration
Growth hormone in the tumor microenvironment
NAD+ Metabolism in Aging and Cancer
Cellular Stress and General Pathological Processes
A prospect of cell immortalization combined with matrix microenvironmental optimization strategy for tissue engineering and regeneration
The expression of P16 and S100 associated with elastin degradation and fibrosis of the Ligamentum Flavum hypertrophy
Risk Factors for Frailty and Cardiovascular Diseases: Are They the Same?
MicroRNAs in the Functional Defects of Skin Aging
Aging, Melatonin, and the Pro-and Anti-Inflammatory Networks
Huang-Lian-Jie-Du decoction ameliorates acute ulcerative colitis in mice via regulating NF-κB and Nrf2 signaling pathways and enhancing intestinal barrier function
Cellular senescence in cultured human brainstem astrocytes: Effect of oxidative stress
A murine aging cell atlas reveals cell identity and tissue-specific trajectories of aging
Exosomal long noncoding RNAs in aging and age‐related diseases
Cellular senescence in the lung across the age spectrum
Modulation of Human Neutrophil Peptides on P. aeruginosa Killing, Epithelial Cell Inflammation and Mesenchymal Stromal Cell Secretome Profiles
Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
Alpha-1 Antitrypsin Deficiency and Accelerated Aging: A New Model for an Old Disease?
ERR agonism reverses mitochondrial dysfunction and inflammation in aging
Senescent hepatocytes in decompensated liver show reduced UPRMT and its key player, CLPP, attenuates senescence in vitro
Thrombin Induces Angiotensin II-Mediated Senescence in Atrial Endothelial Cells: Impact on Pro-Remodeling Patterns
Preventive role of Resveratrol against inflammatory cytokines and related diseases
Towards a unified mechanistic theory of aging
Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology
Autophagy and Immune Tolerance
Investigating the role of microRNAs in the hypoxic response in prostate cancer
Clinical Inference of Serum and Bone Sclerostin Levels in Patients with End-Stage Kidney Disease
Healthy aging: A bibliometric analysis of the literature
Danger signals and inflammaging in osteoarthritis
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
Orexins as novel therapeutic targets in inflammatory and neurodegenerative diseases
Skin Health from the Inside Out
SFRR-E 2019 ANNUAL MEETING “REDOX HOMEOSTASIS: FROM SIGNALING TO DAMAGE”
Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases
Interleukin-1 and related cytokines in the regulation of inflammation and immunity
Plenary Sessions
Premature aging syndromes: From patients to mechanism
Understanding the origin and diversity of macrophages to tailor their targeting in solid cancers
Oxytocin Alleviates Cellular Senescence through Oxytocin Receptor‐Mediated ERK/Nrf2 Signalling
Inflammation and cancer: triggers, mechanisms, and consequences
Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities
Immunobiology of atherosclerosis: a complex net of interactions
Beneficial effect of physical exercise on telomere length and aging, and genetics of aging-associated noncommunicable diseases
Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments
Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis
Methylglyoxal Acts as a Tumor-Promoting Factor in Anaplastic Thyroid Cancer
The potential role of necroptosis in inflammaging and aging
Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic GIT2 in aging trajectories
Enhancement of epithelial cell autophagy induced by sinensetin alleviates epithelial barrier dysfunction in colitis
Age-related inflammation triggers skeletal stem/progenitor cell dysfunction
Quantitative proteomic analyses in blood: A window to human health and disease
The bystander effect contributes to the accumulation of senescent cells in vivo.
Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells
Antioxidative nanomaterials and biomedical applications
Health Benefits of Anti-aging Drugs
Exercise and dietary interventions in a rat model of metabolic knee osteoarthritis
Tissue Engineering and Regenerative Medicine Therapies for Cell Senescence in Bone and Cartilage
Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction
Regulatory mechanisms and clinical manifestations of musculoskeletal aging
Sex Steroids, Cognate Receptors, and Aging
Epigenetic changes during aging and their reprogramming potential
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis
Premature cell senescence in human skin: dual face in chronic acquired pigmentary disorders
140-3D Hydrogels and Bioinks for Realistic In Vitro Modelling and Bioprinting
Impact of aging on bone, marrow and their interactions
FRI0531 THE ARTICULAR PROTECTION EFFECT OF ISORHAMNETIN IN THE RATS OF MONOSODIUM IODOACETATE-INDUCED OSTEOARTHRITIS
Benefits of tree nuts consumption on aging and age-related diseases: mechanisms of actions
Regulation of Wound Healing by the NRF2 Transcription Factor—More Than Cytoprotection
Enhancement of therapeutic efficacy by immunomodulation in human mesenchymal stem cells
PAK4 signaling in development and cancer
Transposable Elements, Inflammation and Neurological Disease
Drugs that target aging: how do we discover them?
Extracellular matrix roles in cardiorenal fibrosis: Potential therapeutic targets for CVD and CKD in the elderly
Murine models of accelerated aging and musculoskeletal disease
Identification of differentially expressed transcription factors and dissecting the role of DREAM complex associated components in cellular senescence
Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets
Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
Acquired Immune Response to Infection
MHY2233 Attenuates Replicative Cellular Senescence in Human Endothelial Progenitor Cells via SIRT1 Signaling
Methods to Quantify the NF-κB Pathway During Senescence
Somatic mutations in healthy cells and age-associated diseases
HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity
Investigating the immune system in chrONIC kidney disease-the SONIC study
JOINT MEETING AGI–SIMAG
Rejuvenation: Turning back the clock of aging kidney
Characterisation of an in vitro aged cell culture model
L1CAM and its role in cellular senescence
The role of the cell-matrix interface in aging and its interaction with the renin-angiotensin system in the aged vasculature
Time for the systems-level integration of aging: Resilience enhancing strategies to prevent Alzheimer’s disease
Epigenetics and Pharmacoepigenetics of Age-Related Neurodegenerative Disorders
Molecular basis of senescence transmitting in the population of human endometrial stromal cells
Shared and distinct mechanisms of fibrosis
Skeletal Muscle Stem Cells
Are There Reliable Biomarkers for Immunosenescence and Inflammaging?
Epidermal growth factor (EGF) intralesional infiltrations: from the bench to the diabetic ulcers cells
Senescence surveillance: the interplay between the immune system and senescent cells
Exosomes as Emerging Pro-Tumorigenic Mediators of the Senescence-Associated Secretory Phenotype
Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions
Recent advances in understanding the phenotypes of osteoarthritis
Inducing Age Related Changes in Microglia as a Model for Neurodegenerative Disease
Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB signaling through activation of PPARγ
Innate immune cell crosstalk induces melanoma cell senescence
Characterization and Analysis of Neural Progenitor Cells from Primary Progressive Multiple Sclerosis Patients
Targeting Cell Senescence for the Treatment of Age-Related Bone Loss
Ell3 functions as a critical decision maker at the crossroad between stem cell senescence and apoptosis
The role of exosomes in regenerative medicine
Mitochondrial dysfunction and cell senescence: deciphering a complex relationship
The Effects of IL-1β on Astrocytes are Conveyed by Extracellular Vesicles and Influenced by Age
The role of senescence in cancer development
41th Volume Index
The proteome of ulcerative colitis-Functional analyses of the active disease and the remission state in comparison with healthy controls
Allostatic load and ageing: linking the microbiome and nutrition with age-related health
Rosiglitazone ameliorates senescence and promotes apoptosis in ovarian cancer induced by olaparib
Novel insights of elevated systemic levels of bisphenol-A (BPA) linked to poor glycemic control, accelerated cellular senescence and insulin resistance in patients with …
Methods for CPP Functionalization
Probing the impact of the maternal environment on foetal development: Can high-resolution telomere analysis predict prenatal adversity?
Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity
Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men
Noncoding RNAs: Bridging Regulation of Circadian Rhythms and Inflammation
Accelerated cardiomyocyte senescence contributes to late-onset doxorubicin-induced cardiotoxicity.
SEXUAL ABUSE: HOW CAN WE KNOW?
Metabolic phenotyping of the human microbiome
Reduced RNA turnover as a driver of cellular senescence
The role of metabolism in the anti-tumor cytotoxicity of natural killer cells
Microncronucleus index in epithelial exfoliated cells of urothelium and buccal mucosa, and peripheral blood lymphocytes of patients with papillary urothelial …
Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells
Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and cartilage regeneration in osteoarthritis
PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation
Mitophagy, Mitochondrial Dynamics, and Homeostasis in Cardiovascular Aging
TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019
Know your enemy: Genetics, aging, exposomic and inflammation in the war against triple negative breast cancer
NAD+ in brain aging and neurodegenerative disorders
Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies
miR-140 Attenuates the Progression of Early-Stage Osteoarthritis by Retarding Chondrocyte Senescence
The dark side of fibroblasts: cancer-associated fibroblasts as mediators of immunosuppression in the tumor microenvironment
The role of signaling pathways of inflammation and oxidative stress in development of senescence and aging phenotypes in cardiovascular disease
Emerging targets of disease-modifying therapy for systemic sclerosis
Identification and characterization of inter-species aging-related transcriptomic regulators
Mouse Models of Accelerated Cellular Senescence
Cranberries–potential benefits in patients with chronic kidney disease
Mitochondrial Homeostasis and Cellular Senescence
Amelioration of age‐related brain function decline by Bruton’s tyrosine kinase inhibition
NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice
Paeonol prevents IL-1β-induced inflammatory response and degradation of type II collagen in human primary chondrocytes
Scarless wound healing: From development to senescence
β cell responses to inflammation
The modular proteome and its significance
Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies
Ferroptosis, a new form of cell death: opportunities and challenges in cancer
Senescence-associated metabolomic phenotype in primary and iPSC-derived mesenchymal stromal cells
Leukocyte Telomere Length in Patients with Radiographic Knee Osteoarthritis
Concepts in Inflammatory Bowel Disease Management
Protein Signatures of Centenarians and Their Offspring Suggest Centenarians Age Slower than Other Humans
Tumor microenvironment: Interactions and therapy
The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1
Stromal cell-derived factor-1 (CXCL12) and its role in bone and muscle biology
Measuring biological aging in humans: A quest
Amelioration of Ductular Reaction by Stem Cell Derived Extracellular Vesicles in MDR2 Knockout Mice via Lethal‐7 microRNA
Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin‐conferred cardioprotection against myocardial ischemia/reperfusion injury
Proteomic Markers for Depression
Induction of Fibroblast Senescence During Mouse Corneal Wound Healing
Regulation of Thirst and Vasopressin Release
Hyper-osmolarity environment-induced oxidative stress injury promotes nucleus pulposus cell senescence in vitro
Novel drug targets in idiopathic pulmonary fibrosis
Sleep, stress, and immunity
Meeting report: Metastasis Research Society (MRS) 17th Biennial conference and associated Young Investigator Satellite Meeting (YISM) on cancer metastasis
Targeting pro-senescence mitogen activated protein kinase (Mapk) enzymes with bioactive natural compounds
Coordination of immune-stroma crosstalk by IL-6 family cytokines
Long non-coding RNA CDKN2B-AS1 reduces inflammatory response and promotes cholesterol efflux in atherosclerosis by inhibiting ADAM10 expression
Proceedings of the 2018 Santa Fe Bone Symposium: Advances in the Management of Osteoporosis
The telomere world and aging: Analytical challenges and future perspectives
The cross-talk between sphingolipids and insulin-like growth factor signaling: significance for aging and neurodegeneration
Young Hematopoietic Stem Cells Ameliorate Age-Associated Phenotypes and Extend Lifespan in Mice
MicroRNA networks modulate oxidative stress in cancer
The RXFP3 receptor is functionally associated with cellular responses to oxidative stress and DNA damage
Crosstalk between HGF and TGF-ß signaling pathways in adult liver progenitor cells and hepatocellular carcinoma cells
The Evolving Role of CD8+ CD28− Immunosenescent T Cells in Cancer Immunology
Astrocytes autophagy in aging and neurodegenerative disorders
Stem cells: a path towards improved epilepsy therapies
Novel function of PiT1/SLC20A1 in LPS-related inflammation and wound healing
Biomarkers of Aging (With a Clinical Potential in Oncology)
Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury
MOTOR BEHAVIOR
Mediterranean Diet (Prong-4)
Resveratrol: A New Potential Therapeutic Agent for Melanoma?
EFFECT OF ADVANCED MATERNAL AGE ON PREGNANCY
MATRIX METALLOPROTEINASES (MMPS) January 16, 2020
Gossypol January 17, 2020
MATRIX METALLOPROTEINASES (MMPS) January 16, 2020
Gossypol January 17, 2020