SKIN PHOTOAGING (Preventing & Repairing)
February 11, 2020ALLERGIES & CYTOKINES
February 16, 2020
- Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
- The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
- Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer
- Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
- Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells
- Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737
- The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak
- The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t (11; 14) multiple myeloma
- Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa
- A BH3 mimetic for killing cancer cells
- ABT-199, a new Bcl-2–specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia
- Initial testing (stage 1) of the BH3 mimetic ABT‐263 by the pediatric preclinical testing program
- Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic
- A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2–Beclin1 interaction at endoplasmic reticulum
- BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells
- BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells
- In vitro effects of the BH3 mimetic,(−)-gossypol, on head and neck squamous cell carcinoma cells
- Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma
- A novel BH3 mimetic reveals a mitogen-activated protein kinase–dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species
- The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia
- Reversal of cisplatin resistance with a BH3 mimetic,(−)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL
- Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo
- BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts
- Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737
- MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents
- BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis
- Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B …
- BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic …
- A novel BH3 mimetic S1 potently induces Bax/Bak‐dependent apoptosis by targeting both Bcl‐2 and Mcl‐1
- A phase 2 study of the BH3 mimetic BCL2 inhibitor navitoclax (ABT-263) with or without rituximab, in previously untreated B-cell chronic lymphocytic leukemia
- Overcoming blocks in apoptosis with BH3-mimetic therapy in haematological malignancies
- Alterations in the Noxa/Mcl-1 axis determine sensitivity of small cell lung cancer to the BH3 mimetic ABT-737
- Structural Basis of Bcl‐xL Recognition by a BH3‐mimetic α/β‐Peptide Generated by Sequence‐Based Design
- The BH3-mimetic GX15-070 induces autophagy, potentiates the cytotoxicity of carboplatin and 5-fluorouracil in esophageal carcinoma cells
- The BH3 mimetic ABT-737 induces cancer cell senescence
- CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies
- Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells
- Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax
- Endogenous Noxa determines the strong proapoptotic synergism of the BH3-mimetic ABT-737 with chemotherapeutic agents in human melanoma cells
- BH3-mimetic drugs: blazing the trail for new cancer medicines
- ABT-199, a BH3 mimetic that specifically targets Bcl-2, enhances the antitumor activity of chemotherapy, bortezomib and JQ1 in “double hit” lymphoma cells
- The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells
- … is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (−)-Gossypol (AT-101)
- Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice
- Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis
- Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT …
- Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts
- The BCL-2-specific BH3-mimetic ABT-199 (GDC-0199) is active and well-tolerated in patients with relapsed non-Hodgkin lymphoma: interim results of a phase I study
- ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress
- The BH3-mimetic ABT-737 sensitizes human melanoma cells to apoptosis induced by selective BRAF inhibitors but does not reverse acquired resistance
- Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells
- The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance
- Interference with the HSF1/HSP70/BAG3 pathway primes glioma cells to matrix detachment and BH3 mimetic–induced apoptosis
- γ-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells
- Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor–related apoptosis …
- Sorafenib sensitizes glioma cells to the BH3 mimetic ABT-737 by targeting MCL1 in a STAT3-dependent manner
- The combination of a histone deacetylase inhibitor with the BH3-mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy
- The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the …
- The combination of BH3-mimetic ABT-737 with the alkylating agent temozolomide induces strong synergistic killing of melanoma cells independent of p53
- The BH3 mimetic ABT-737 increases treatment efficiency of paclitaxel against hepatoblastoma
- Actinomycin D synergistically enhances the efficacy of the BH3 mimetic ABT-737 by downregulating Mcl-1 expression
- Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis
- Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
- The BH3 mimetic obatoclax accumulates in lysosomes and causes their alkalinization
- The BH3-mimetic ABT-737 induces mast cell apoptosis in vitro and in vivo: potential for therapeutics
- DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis
- Synergistic killing of human small cell lung cancer cells by the Bcl-2-inositol 1, 4, 5-trisphosphate receptor disruptor BIRD-2 and the BH3-mimetic ABT-263
- BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells
- Bcl-xL–inhibitory BH3 mimetic ABT-737 depletes platelet calcium stores
- … -induced apoptosis in non-small-cell lung cancer cells is dependent on Bax-and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 …
- BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis
- The selective Bcl-2 inhibitor venetoclax, a BH3 mimetic, does not dysregulate intracellular Ca2+ signaling
- S63845, an MCL-1 selective BH3 mimetic: another arrow in our quiver
- The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia initiating cells
- BMX acts downstream of PI3K to promote colorectal cancer cell survival and pathway inhibition sensitizes to the BH3 mimetic ABT-737
- SIRT3 participates in glucose metabolism interruption and apoptosis induced by BH3 mimetic S1 in ovarian cancer cells
- HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines
- Combining the antimesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cells
- S1, a novel pan- BH3 mimetic, induces apoptosis in Mcl-1-overexpressing cells through Bak
- The BH3 mimetic S1 induces endoplasmic reticulum stress-associated apoptosis in cisplatin-resistant human ovarian cancer cells although it activates …
- Treatment with a BH3 mimetic overcomes the resistance of latency III EBV (+) cells to p53-mediated apoptosis
- Activity of the BH3 mimetic ABT-737 on polycythemia vera erythroid precursor cells
- The BH3‐mimetic ABT‐737 inhibits allogeneic immune responses
- The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling
- Knockdown of BAG3 sensitizes bladder cancer cells to treatment with the BH3 mimetic ABT-737
- Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling
- Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL
- Metronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effects
- BH3-mimetic gossypol-induced autophagic cell death in mutant BRAF melanoma cells with high expression of p21Cip1
- BH3-mimetic toolkit guides the respective use of BCL2 and MCL1 BH3-mimetics in myeloma treatment
- Inhibition of JNK3 promotes apoptosis induced by BH3 mimetic S1 in chemoresistant human ovarian cancer cells
- A novel bioavailable BH3 mimetic efficiently inhibits colon cancer via cascade effects of mitochondria
- Prophylactic treatment with the BH3 mimetic ABT-737 impedes Myc-driven lymphomagenesis in mice
- The IGF-1 receptor inhibitor picropodophyllin potentiates the anti-myeloma activity of a BH3-mimetic
- The role of BH3-mimetic drugs in the treatment of pediatric hepatoblastoma
- Cell death induction by the BH3 mimetic GX15-070 in thyroid carcinoma cells
- BH3‐domain mimetic compound BH3I‐2′ induces rapid damage to the inner mitochondrial membrane prior to the cytochrome c release from mitochondria
- Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in …
- Defective autophagy in multidrug resistant cells may lead to growth inhibition by BH3‐mimetic gossypol
- BH3-mimetic ABT-737 induces strong mitochondrial membrane depolarization in platelets but only weakly stimulates apoptotic morphological changes, platelet …
- Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells
- Identification of predictive factors of response to the BH3‐mimetic molecule ABT‐737: An ex vivo experiment in human serous ovarian carcinoma
- BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in …
- Gamma-tocotrienol acts as a BH3 mimetic to induce apoptosis in neuroblastoma SH-SY5Y cells
- Pancreatic cancer combination therapy using a BH3 mimetic and a synthetic tetracycline
- … -of-function mutations associated with autoimmune lymphoproliferative syndrome like disease deregulate lymphocyte apoptosis and can be targeted by BH3 mimetic …
- The BH3-mimetic obatoclax reduces HIF-1α levels and HIF-1 transcriptional activity and sensitizes hypoxic colon adenocarcinoma cells to 5-fluorouracil
- The BH3-mimetic ABT-737 targets the apoptotic machinery in cholangiocarcinoma cell lines resulting in synergistic interactions with zoledronic acid
- Canonical Bcl-2 motifs of the Na+/K+ pump revealed by the BH3 mimetic chelerythrine: early signal transducers of apoptosis?
- Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity
- The Bcl-2 homology domain 3 (BH3) mimetic ABT-737 reveals the dynamic regulation of bad, a proapoptotic protein of the Bcl-2 family, by Bcl-xL
- Pharmacological blockade of Bcl-2, Bcl-x L and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice
- The BH3 mimetic drug ABT-737 induces apoptosis and acts synergistically with chemotherapeutic drugs in thyroid carcinoma cells
- The BH3 mimetic HA14-1 enhances 5-fluorouracil-induced autophagy and type II cell death in oesophageal cancer cells
- Antiapoptotic BCL-2 proteins determine sorafenib/regorafenib resistance and BH3-mimetic efficacy in hepatocellular carcinoma
- Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid …
- Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2
- Metastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737
- Cytoprotective role of autophagy against BH3 mimetic gossypol in ATG5 knockout cells generated by CRISPR-Cas9 endonuclease
- BH3-mimetic small molecule inhibits the growth and recurrence of adenoid cystic carcinoma
- BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux
- MLN2238 synergizes BH3 mimetic ABT-263 in castration-resistant prostate cancer cells by induction of NOXA
- The BCL-2-specific BH3-mimetic ABT-199 (GDC-0199) is active and well-tolerated in patients with relapsed/refractory chronic lymphocytic leukemia: interim results of …
- 2-Deoxyglucose treatment complements the cisplatin-or BH3-only mimetic-induced suppression of neuroblastoma cell growth
- BH3 mimetic ABT-737 sensitizes colorectal cancer cells to ixazomib through MCL-1 downregulation and autophagy inhibition
- Possible Mechanisms Of Resistance To The Novel BH3-mimetic ABT-199 In In Vitro Lymph Node Models Of CLL – The Role Of Abl and Btk
- Preliminary results of a phase II open-label, randomized study of the BH3 mimetic protein navitoclax (ABT-263) with or without rituximab for treatment of …
- Novel therapy of prostate cancer employing a combination of viral-based immunotherapy and a small molecule BH3 mimetic
- BH3 mimetic-elicited Ca 2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca 2+-like peptides
- Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer
- BCL-2-Selective BH3 mimetic ABT-199 Is a potent agent for acute myeloid leukemia
- Effect of the BH3 mimetic Polyphenol (–)-Gossypol (AT-101) on the in vitro and in vivo Growth of Malignant Mesothelioma
- BCL-xL-selective BH3 mimetic sensitizes rhabdomyosarcoma cells to chemotherapeutics by activation of the mitochondrial pathway of apoptosis
- Pan‐ BH3 mimetic S1 Exhibits Broad‐Spectrum Antitumour Effects by Cooperation between Bax and Bak
- BH3-mimetic drugs prevent tumour onset in an orthotopic mouse model of hepatoblastoma
- Cyclin-dependent kinase 2 inhibitor SU9516 increases sensitivity of colorectal carcinoma cells Caco-2 but not HT29 to BH3 mimetic ABT-737
- ABT‐199 (Venetoclax), a BH3‐mimetic Bcl‐2 inhibitor, does not cause Ca2+‐signalling dysregulation or toxicity in pancreatic acinar cells
- Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies
- The BH3-mimetic Obatoclax Restores the Response to Dexamethasone in Glucocorticoid-Resistant ALL through Induction of Autophagy.
- A novel BH3 mimetic reveals a MAPK-dependent mechanism of melanoma cell survival controlled by p53 and reactive oxygen species
- The pro-death role of autophagy and apoptosis in cell death induced by the BH3 mimetic gossypol
- A small molecule BH3-mimetic suppresses cigarette smoke-induced mucous expression in airway epithelial cells
- Computational analyses on delineating specificity of 2-hydroxy-3, 5-dinitrobenzamide, a BH3-mimetic, towards anti-apoptotic proteins
- Combination Treatment with the BRAFV600E Inhibitor Vemurafenib and the BH3 mimetic Navitoclax for BRAF-Mutant Thyroid Carcinoma
- BH3 mimetic ABT-199 Enhances the Sensitivity of Gemcitabine in Pancreatic Cancer in vitro and in vivo
- The PPARγ agonist rosiglitazone sensitizes the BH3 mimetic (−)‐gossypol to induce apoptosis in cancer cells with high level of Bcl‐2
- Pushing cancer cells to commit suicide: Is 072RB, the new BH3 mimetic, up to the job?
- BH3 mimetic therapy: an emerging and promising approach to treating chronic lymphocytic leukemia
- The BH3-only mimetic ABT-737 synergizes the antineoplastic activity of proteasome inhibitors in lymphoid malignancies
- The BH3-mimetic obatoclax (GX15-070) posses a dual-mechanism of action and induces both apoptosis and autophagy-dependent cell death of B cell non-Hodgkin’s …
- Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment
- Synergistic cytotoxicity of a prostate cancer-specific immunotoxin in combination with the BH3 mimetic ABT-737
- Effect of the BH3 mimetic ABT-737 on human melanoma cells to apoptosis induced by selective BRAF inhibitors.
- Nutrient starvation sensitizes human ovarian Cancer SKOV3 cells to BH3 mimetic via modulation of mitochondrial dynamics
- Biomarkers and In Vivo Responses to the BH3 Mimetic, ABT-263, in Patients (pts) with Chronic Lymphocytic Leukemia (CLL).
- Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL
- Cell Death Induction by the Indirubin Derivative 7BIO and the BH3 mimetic Drugs ABT-737 and GX15-070 in Medullary Thyroid Carcinoma Cells
- Obatoclax, a BH3 mimetic, enhances cisplatin-induced apoptosis and decreases the clonogenicity of muscle invasive bladder cancer cells via mechanisms that involve …
- Autophagy-mediated growth inhibition of malignant glioma cells by the BH3-mimetic gossypol
- A Dual BH3-mimetic approach targeting BCL-2 and MCL1 is highly efficacious and well-tolerated in Acute Myeloid Leukemia
- MIM1, the Mcl-1–specific BH3 mimetic induces apoptosis in human U87MG glioblastoma cells
- Targeting the apoptotic machinery of pediatric acute lymphoblastic leukemia in vivo using the BH3-mimetic ABT-737
- The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and …
- BH3 mimetic Augments the Induction of Apoptosis by INNO-406, a Novel Bcr-Abl/Lyn Inhibitor, in Bcr-Abl+ Leukemic Cells.
- A phase I study of AT-101, a BH3 mimetic, in combination with paclitaxel and carboplatin in solid tumors
- Targeting the BCL-2 family of proteins in hodgkin lymphoma: in vitro cytotoxicity, target modulation and drug combination studies of the BH3 mimetic ABT-737
- BCL-2 Phosphorylation Modulates Sensitivity to the BH3-mimetic GX15-070 (Obatoclax) and Reduces Its Synergistic Interaction with Bortezomib in Chronic …
- Disruption of Bcl-2 Heterodimerization by the BH3 mimetic ABT-737 Restores Spontaneous Apoptosis and Induces Differentiation in High Risk MDS and AML.
- By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737
- Intrinsic resistance of prostate cancer to the BH3 mimetic ABT-737 is related to expression of the anti-apoptotic Mcl-1 and additional survival and apoptosis regulating …
- Studies of the combination of ABT-199, a BH3 mimetic that specifically targets Bcl-2 in combination with chemotherapy and the proteosome inhibitor bortezomib in” …
- … 2 Dual Inhibitors Created by the Structure‐Based Hybridization of Drug‐Divided Building Blocks and a Fragment Deconstructed from a Known Two‐Face BH3 Mimetic
- Bim–BH3-mimetic tHerapy for ra
- RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines
- BRAF inhibition is enhanced by BH3-mimetic through BIM induction.
- Decoding The BH3-mimetic Pro-Apoptotic Activity Of Quercetin In Jurkat Cells
- Novel BH3 mimetic based therapeutic strategies for the treatment of breast cancer
- inhibitory BH3 mimetic ABT-737 depletes platelet calcium stores− L Bcl-x
- … FOR THE USE OF MCL1/BCL2 BH3 mimetic COMBINATION TO EFFECTIVELY KILL PRIMARY MYELOMA CELLS INSENSITIVE TO EACH BH3 mimetic ALONE …
- Apoptosis mechanism induced by BH3 mimetic S1 in human leukemia cell line K562
- Efficacy of the BH3-mimetic ABT-199 in acute lymphoblastic leukemia
- To explore the use of a BH3-mimetic (ABT-737) as a chemosensitizer of osteosarcoma cells to doxorubicin.
- Activity of the BH3 mimetic ABT-737 on Polycythemia Vera (PV) Erythroid Precursor Cells
- Design and activity detection of BH3-mimetic peptide based on Bcl-XL binding potency
- The BH3 mimetic navitoclax (ABT-263) selectively induces apoptosis in cholangiocarcinoma-associated fibroblasts thereby reducing tumor growth
- Identification of Potent BH3-mimetic Combinations Targeting Pro-Survival Pathways in Human B-Cell Acute Lymphoblastic Leukemia
- A p21Cip1-dependent autophagic cell death by BH3-mimetic gossypol in mutant BRAF melanoma cells (796.4)
- Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly
- Maritoclax, a selective Mcl-1 inhibitor, sensitizes melanoma cells to the Bad BH3-mimetic ABT-737.
- IDENTIFICATION OF POTENT BH3-mimetic COMBINATIONS TARGETING PRO-SURVIVAL PATHWAYS IN HUMAN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
- Relationship between BH3 mimetic S1 and expression of BCL-2 family members in acute myeloid leukemia
- Treatment with a BH3 mimetic overcomes the resistance of latency III EBV (+) cells to p53-mediated apoptosis.
- DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis
- The BH3 mimetic GX015-070 (Obatoclax) induces apoptosis and growth inhibition in neoplastic mast cells
- Induction of Bim by the BRAF inhibitor PLX4720 sensitizes human melanoma cells to the BH3 mimetic ABT-737
- Abstract P2-09-01: Targeting BCL-2 with the BH3 mimetic ABT-199 in ER-positive breast cancer
- BH3-mimetic gossypol promotes autophagy to inhibit the proliferation of mutant BRAF melanoma cells with high expression of p21Cip1
- Inhibition of prosurvival autophagy by the BH3-mimetic obatoclax sensitizes antiestrogen-resistant breast cancer cells to apoptosis
- Failure of autophagy induction makes multidrug resistant cells vulnerable to BH3-mimetic gossypol
- Abstract A28: Apoptosis induction with the MEK inhibitor AZD6244 and BH3 mimetic ABT-737 in melanoma.
- PL-09. MEDULLOBLASTOMA IS PRIMED FOR RAPID APOPTOSIS BY CONSTITUTIVELY ACTIVE BAX AND IS HIGHLY SENSITIVE TO BH3 mimetic THERAPY
- Functional disparity among BCL-2 members in tonsillar and leukemic B cell subsets probed by next generation BH3 mimetic profiling
- 695 The BH3 Mimetic, Small Molecule, ABT-737, Was Effective As Lympholytic Therapy in the MRL/lpr-/-Mouse Model of Autoimmune Lymphoproliferative Syndrome …
- S1, a Bid-like BH3 mimetic, induces apoptosis by dynamic change of Mcl-1 and dependent on Bak, not Bax
- Acquired cisplatin resistance in malignant pleural mesothelioma cells is reversed by both BH3-mimetic obatoclax and IAP-inhibitor AT-406
- Broad spectrum BH3 mimetic BI-97D6 induces apoptosis of acute myeloid leukemia cells even when co-cultured with supporting stromal cells
- ABT-737, A BH3 MIMETIC, LEADS TO RADIOSENSITIZATION OF HEAD AND NECK SQUAMOUS CELL CARCINOMA VIA INDUCTION OF INTRAMITOCHONDRIAL …
- The BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptosis by releasing Bim and Bak proteins in human pancreatic cancer cells
- Combination of the IGF-1 Receptor Inhibitor Picropodophylin and the BH3 mimetic ABT-737 Has Synergistic Anti-Myeloma Activity
- Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck
- A potent BH3 mimetic targeting BCL-XL induces apoptosis regulated by PTEN loss and integrin alpha 5 in prostate cancer cells
- The BH3 mimetic Obatoclax (GX015-070) synergistically enhances TRAIL-mediated apoptosis by activating Bak and Bax in human pancreatic cancer cells
- Identification of a novel mechanism by which the BH3 mimetic obatoclax sensitizes non-Hodgkin’s lymphoma tumor cells to TRAIL-mediated apoptosis
- The deubiquitinating enzyme OTUD1 antagonizes BH3-mimetic inhibitor induced cell death through regulating the stability of the MCL1 protein
- Combining the anti-mesothelin immunotoxin SS1P with the BH3-mimetic ABT-737 induces cell death in SS1P-resistant pancreatic cancer cell lines.
- The BH3 Mimetic, Small Molecule, ABT-737, Was Effective As Lympholytic Therapy in the MRL/lpr−/− Mouse Model of Autoimmune Lymphoproliferative Syndrome …
- The BH3-mimetic ABT-737 Reverses the Intrinsic Radioresistance of Head and Neck Squamous Carcinoma Stem and Non-stem Cells
- Abstract LB-23: In vivo exposure of infant leukemia to the BH3-mimetic ABT-263 selects for a cell death-resistant phenotype
- Microfluidic profiling of apoptosis-related genes after treatment with BH3-mimetic agents in astrocyte and glioblastoma cell lines
- Abstract B26: Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts
- Possible molecular mechanisms and pathways involved in BH3 mimetic activity of alpha-lipoic acid on human colon cancer cell line
- S110 (−)-Gossypol, a BH3 mimetic and Inducer of Apoptosis in Head and Neck Cancer Cells, Is Oxidized and Deactivated by ROS
- S63845, a novel BH3 mimetic Mcl-1 inhibitor synergizes with midostaurin to induce potent apoptosis in acute myeloid leukemia cells carrying FLT3-ITD mutations
- A short term biomarker-based assay predicts apoptotic response to combined BCL-2/MCL-1 BH3 mimetic targeting in Myeloma cells
- Supplemental data Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia
- Abstract# 374: BH3 mimetic, ABT-737, enhances celecoxib-induced apoptosis that can be further augmented by inhibition of autophagy in human colon cancer cells.
- Abstract# 2786: Apoptosis induced by JAK2 inhibition requires Bim and is enhanced by a BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells
- BH3 mimetic ABT-263 enhances the anticancer effects of apigenin in tumor cells with activating EGFR mutation
- Mechanisms underlying synergistic interactions between the CDK inhibitor flavopiridol (Alvocidib) and the BH3 mimetic GX15-070 (Obatoclax) in human multiple …
- The BH3-mimetic GX15-070 induces autophagy-dependent cell death of therapy-sensitive and-resistant aggressive B cell non-Hodgkin’s lymphoma (B-NHL)
- The BH3 mimetic compound BH3I-1 impairs mitochondrial dynamics and promotes stress response in addition to its pro-apoptotic key function
- P2. 05-004 ABT-737, a BH3 Mimetic, Enhances Therapeutic Effect of Ionizing Radiation in Murine Lung Cancer Model: Topic: Biology
- The BH3 Mimetic, ABT-737, Overcomes Stromal-Mediated Pro-Survival Signals and Synergizes with PHA-767491, a Dual Cdc7/CDK9 Inhibitor, In Acute Myeloid …
- Synergistic cytotoxic/apoptotic effects of AT-101, a phytochemical with BH3-mimetic property, in combination with paclitaxel in human breast cancer cells.
- Cover Picture: Structural Basis of Bcl‐xL Recognition by a BH3‐mimetic α/β‐Peptide Generated by Sequence‐Based Design (ChemBioChem 13/2011)
- Examination of 4-hydroxy tamoxifen-and BH3 mimetic-induced cell death pathways in glioblastoma and malignant peripheral nerve sheath tumor cells
- A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma
- Supplemental data The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
- Abstract# 3276: The BH3 mimetic Obatoclax (GX15-070) sensitized B-NHL cells to TRAIL-mediated apoptosis by activating Bak and inhibiting Mcl-1, NF-\# 954; B and …
- Compounds and methods for inducing apoptosis in cancer cells using a BH3 alpha-helical mimetic
