NON OPIOD ANALGESICS
March 22, 2021ISOFLAVONES
March 22, 2021
- Mechanism of action of the immunosuppressant Rapamycin
- Rapamycin in transplantation: a review of the evidence
- Rapamycin: Clinical Results and Future Opportunities1
- Targets for cell cycle arrest by the immunosuppressant Rapamycin in yeast
- The target of Rapamycin (TOR) proteins
- Solubilization of Rapamycin
- Rapamune (Sirolimus, Rapamycin): an overview and mechanism of action.
- Total synthesis of Rapamycin
- Activity of Rapamycin (AY-22, 989) against transplanted tumors
- Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k
- SDZ RAD, a new Rapamycin derivative: pharmacological properties in vitro and in vivo
- Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
- Regulation of cellular growth by the Drosophila target of Rapamycin dTOR
- Bench to bedside: the development of Rapamycin and its application to stent restenosis
- Rapamycin (AY-22, 989), a new antifungal antibiotic II. Fermentation, isolation and characterization
- Two TOR complexes, only one of which is Rapamycin sensitive, have distinct roles in cell growth control
- Rapamycin (AY-22, 989), a new antifungal antibiotic I. Taxonomy of the producing streptomycete and isolation of the active principle
- The Rapamycin-sensitive signal transduction pathway as a target for cancer therapy
- A mammalian protein targeted by G1-arresting Rapamycin–receptor complex
- Rapamycin inhibits vascular smooth muscle cell migration.
- TOR mutations confer Rapamycin resistance by preventing interaction with FKBP12-Rapamycin
- Isolation of a protein target of the FKBP12-Rapamycin complex in mammalian cells
- Rapamycin selectively represses translation of the” polypyrimidine tract” mRNA family
- Phosphorylation of the translational repressor PHAS-I by the mammalian target of Rapamycin
- Rapamycin: distribution, pharmacokinetics and therapeutic range investigations: an update.
- Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
- Elucidating TOR signaling and Rapamycin action: lessons from Saccharomyces cerevisiae
- Biosynthesis of erythromycin and Rapamycin
- Blood distribution of Rapamycin.
- Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of Rapamycin
- Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of Rapamycin
- Studies on the mechanism of resistance to Rapamycin in human cancer cells
- A Rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
- Rapamycin: distribution, pharmacokinetics, and therapeutic range investigations.
- Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy1
- Structure of the FKBP12-Rapamycin complex interacting with binding domain of human FRAP
- Expression and disruption of the Arabidopsis TOR (target of Rapamycin) gene
- Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro
- The biosynthetic gene cluster for the polyketide immunosuppressant Rapamycin
- Mammalian target of Rapamycin (mTOR): pro-and anti-apoptotic
- SDZ RAD, a new Rapamycin derivative: synergism with cyclosporine
- Rapamycin (AY-22, 989), A NEW ANTIFUNGAL ANTIBIOTIC III. IN VITRO AND IN VIVO EVALUATION
- RAFT1: a mammalian protein that binds to FKBP12 in a Rapamycin-dependent fashion and is homologous to yeast TORs
- p53/p21CIP1 cooperate in enforcing Rapamycin-induced G1 arrest and determine the cellular response to Rapamycin
- Raptor, a binding partner of target of Rapamycin (TOR), mediates TOR action
- Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
- The principal target of Rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.
- Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
- The immunosuppressant Rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
- Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells
- TOR kinase domains are required for two distinct functions, only one of which is inhibited by Rapamycin
- inhibition of cell cycle progression by Rapamycin induces T cell clonal anergy even in the presence of costimulation
- Revised NMR assignments for Rapamycin
- Rapamycin blocks the phosphorylation of 4E‐BP1 and inhibits cap‐dependent initiation of translation.
- Absorption and intestinal metabolism of SDZ-RAD and Rapamycin in rats
- Rapamycin resistance tied to defective regulation of p27Kip1.
- RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/Rapamycin complex
- Targeted disruption of p70s6k defines its role in protein synthesis and Rapamycin sensitivity
- Target of Rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
- Rapamycin prolongs survival and arrests pathophysiologic changes in murine systemic lupus erythematosus
- Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins
- SIROLIMUS (Rapamycin)-BASED THERAPY IN HUMAN RENAL TRANSPLANTATION: Similar Efficacy and Different Toxicity Compared with Cyclosporine: 1, 2
- Inhibitors of mammalian target of Rapamycin as novel antitumor agents: from bench to clinic
- Cytoplasmic–nuclear shuttling of FKBP12-Rapamycin-associated protein is involved in Rapamycin-sensitive signaling and translation initiation
- A protein kinase B-dependent and Rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification
- Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability
- A chemical genomics approach toward understanding the global functions of the target of Rapamycin protein (TOR)
- Mechanism of metabolic control: target of Rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors
- Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a Rapamycin-sensitive pathway
- inhibition of human B lymphocyte cell cycle progression and differentiation by Rapamycin
- Mammalian target of Rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on …
- Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or Rapamycin.
- Cyclosporin A, FK506 and Rapamycin: more than just immunosuppression
- Rapamycin inhibits human adipocyte differentiation in primary culture
- Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells
- inhibition of T and B lymphocyte proliferation by Rapamycin.
- Target of Rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation
- Partitioning the transcriptional program induced by Rapamycin among the effectors of the Tor proteins
- Rapamycin (AY-22, 989), A NEW ANTIFUNGAL ANTIBIOTIC IV. MECHANISM OF ACTION
- Control of translation by the target of Rapamycin proteins
- Control of Ser2448 phosphorylation in the mammalian target of Rapamycin by insulin and skeletal muscle load
- Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of Rapamycin mediated by a protein kinase B signaling pathway
- Serum‐stimulated, Rapamycin‐sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI
- Rapamune®(RAPA, Rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle …
- Regulation of Ribosome Biogenesis by the Rapamycin-sensitive TOR-signaling Pathway in Saccharomyces cerevisiae
- Enhancement of human platelet aggregation and secretion induced by Rapamycin.
- A Rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
- Biochemical correlates of mTOR inhibition by the Rapamycin ester CCI-779 and tumor growth inhibition
- The mammalian target of Rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism
- Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via Rapamycin (mTOR)‐dependent signaling
- Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites
- Immunopurified mammalian target of Rapamycin phosphorylates and activates p70 S6 kinase α in vitro
- The principal Rapamycin-sensitive p70 (s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by Rapamycin-insensitive kinase kinases.
- Direct inhibition of the signaling functions of the mammalian target of Rapamycin by the phosphoinositide 3‐kinase inhibitors, wortmannin and LY294002.
- The Rapamycin-binding domain governs substrate selectivity by the mammalian target of Rapamycin
- Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells
- Interaction of RAFT1 with gephyrin required for Rapamycin-sensitive signaling
- Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells
- Suppression of B cell activation by cyclosporin A, FK506 and Rapamycin
- Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins
- Rapamycin and FK506 binding proteins (immunophilins)
- Rapamycin inhibits hepatic stellate cell proliferation in vitro and limits fibrogenesis in an in vivo model of liver fibrosis
- On the chemistry and high field nuclear magnetic resonance spectroscopy of Rapamycin
- Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and Rapamycin
- Neurotrophic actions of nonimmunosuppressive analogues of immunosuppressive drugs FK506, Rapamycin and cyclosporin A
- Activated mammalian target of Rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
- inhibition of the mammalian target of Rapamycin sensitizes U87 xenografts to fractionated radiation therapy
- Atomic structure of the Rapamycin human immunophilin FKBP-12 complex
- The FKBP12-Rapamycin-binding domain is required for FKBP12-Rapamycin-associated protein kinase activity and G1 progression
- A novel pathway regulating the mammalian target of Rapamycin (mTOR) signaling
- Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the Rapamycin target mTOR
- Mammalian target of Rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling
- Rapamycin: a bone sparing immunosuppressant?
- Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of Rapamycin
- Mechanism of action of Rapamycin: New insights into the regulation of G1-phase progression in eukaryotic cells
- Preclinical evaluation of a new potent immunosuppressive agent, Rapamycin.
- Early clinical experience with a novel Rapamycin derivative
- Antitumor activity of the Rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination …
- AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of Rapamycin (mTOR) signaling
- Total synthesis of Rapamycin and demethoxyRapamycin
- Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway
- Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and Rapamycin in rat adipocytes
- Synergistic interactions of cyclosporine and Rapamycin to inhibit immune performances of normal human peripheral blood lymphocytes in vitro.
- Interaction between FKBP12-Rapamycin and TOR involves a conserved serine residue.
- Comparison of acute Rapamycin nephrotoxicity with cyclosporine and FK506
- Refined structure of the FKBP12–Rapamycin–FRB ternary complex at 2.2 Å resolution
- Immunosuppressants FK506 and Rapamycin function as reversal agents of the multidrug resistance phenotype
- Regulation of the cell integrity pathway by Rapamycin-sensitive TOR function in budding yeast
- Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells
- Sirolimus (Rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease1
- Hyperlipidemia in renal transplant recipients treated with sirolimus (Rapamycin)
- Effects of Rapamycin on Ryanodine Receptor/Ca2+-Release Channels From Cardiac Muscle
- Conversion to Rapamycin immunosuppression in renal transplant recipients: report of an initial Experience1
- Global and specific translational control by Rapamycin in T cells uncovered by microarrays and proteomics
- Synergistic effects of cyclosporine and Rapamycin in a chronic nephrotoxicity model1
- Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells
- Total synthesis of (-)-Rapamycin using an Evans-Tishchenko fragment coupling
- FKBP12-Rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions
- Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein.
- Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G1 phase of the cycle
- FKBP12-Rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
- Modulation of transcription of rRNA genes by Rapamycin
- The effect of Rapamycin on kidney function in the Sprague-Dawley rat.
- Organization of the biosynthetic gene cluster for Rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase
- Growth-dependent translation of IGF-II mRNA by a Rapamycin-sensitive pathway
- Effects of Rapamycin in experimental organ allografting.
- Metabolic and autocrine regulation of the mammalian target of Rapamycin by pancreatic β-cells
- Predominant nuclear localization of mammalian target of Rapamycin in normal and malignant cells in culture
- Effect of nitrogen source on biosynthesis of Rapamycin by Streptomyces hygroscopicus
- Rapamycin‐sensitive phase of 3T3‐L1 preadipocyte differentiation after clonal expansion
- The mammalian target of Rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus
- Rapamycin eluting stent: the onset of a new era in interventional cardiology
- Efficacy of sirolimus (Rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled …
- B cell receptor-associated protein α4 displays Rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A
- The immunosuppressant Rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sites
- Regulation of translational effectors by amino acid and mammalian target of Rapamycin signaling pathways: possible involvement of autophagy in cultured …
- Molecular mechanisms of immunosuppression by cyclosporine, FK506, and Rapamycin.
- … vascular smooth muscle cell DNA synthesis. inhibition of basic fibroblast growth factor and platelet-derived growth factor action and antagonism of Rapamycin by …
- Mammalian target of Rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and …
- Influence of cyclosporin, tacrolimus and Rapamycin on renal function and arterial hypertension after renal transplantation
- Antifungal activities of Rapamycin and its derivatives, prolylRapamycin, 32-desmethylRapamycin, and 32-desmethoxyRapamycin
- Rapamycin inhibits macropinocytosis and mannose receptor–mediated endocytosis by bone marrow–derived dendritic cells
- Pharmacokinetics of Rapamycin.
- The immunosuppressant Rapamycin represses human immunodeficiency virus type 1 replication
- Treatment with Rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement.
- Rapamycin inhibits arterial intimal thickening caused by both alloimmune and mechanical injury. Its effect on cellular, growth factor, and cytokine response in injured …
- Rapamycin reverses chronic graft vascular disease in a novel cardiac allograft model
- Total synthesis of Rapamycin via a novel titanium-mediated aldol macrocyclization reaction
- Cyclosporin A, FK-506, and Rapamycin: pharmacologic probes of lymphocyte signal transduction
- Enhancement of the antifungal activity of Rapamycin by the coproduced elaiophylin and nigericin
- … X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and Rapamycin
- Mammalian target of Rapamycin-dependent phosphorylation of PHAS-I in four (S/T) P sites detected by phospho-specific antibodies
- Rapamycin induces apoptosis in monocyte-and CD34-derived dendritic cells but not in monocytes and macrophages
- Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple Rapamycin-sensitive steps
- Clinical development of mammalian target of Rapamycin inhibitors
- Identification of an 11-kDa FKBP12-Rapamycin-binding domain within the 289-kDa FKBP12-Rapamycin-associated protein and characterization of a critical serine …
- COMBINED COSTIMULATION BLOCKADE PLUS Rapamycin BUT NOT CYCLOSPORINE PRODUCES PERMANENT ENGRAFTMENT1
- Effect of amino acids on Rapamycin biosynthesis by Streptomyces hygroscopicus
- Rapamycin antifungal action is mediated via conserved complexes with fkbp12 and tor kinase homologs incryptococcus neoformans
- Rapamycin-induced inhibition of p34cdc2 kinase activation is associated with G1/S-phase growth arrest in T lymphocytes.
- Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate Rapamycin cytotoxicity.
- … autophagy and activation of lysosome-dependent proteolysis in C2C12 myotubes through a mammalian target of Rapamycin-independent signaling pathway
- Control of PHAS-I by insulin in 3T3-L1 adipocytes: synthesis, degradation, and phosphorylation by a Rapamycin-sensitive and mitogen-activated protein …
- Stress-activated protein kinase-2/p38 and a Rapamycin-sensitive pathway are required for C2C12 myogenesis
- Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR
- Rapamycin (sirolimus, rapamune).
- Organisation of the biosynthetic gene cluster for Rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase
- Rapamycin selectively inhibits angiotensin II–induced increase in protein synthesis in cardiac myocytes in vitro: potential role of 70-kD S6 kinase in angiotensin II …
- Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of Rapamycin-dependent signaling pathway
- Resistance to Rapamycin: a novel anticancer drug
- Carbon source nutrition of Rapamycin biosynthesis in Streptomyces hygroscopicus
- Osteoblastic differentiation is enhanced by Rapamycin in rat osteoblast-like osteosarcoma (ROS 17/2.8) cells
- Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of Rapamycin phosphorylation site
- The Rapamycin analogue SDZ RAD attenuates bleomycin-induced pulmonary fibrosis in rats
- Regulation of translation elongation factor‐2 by insulin via a Rapamycin‐sensitive signalling pathway.
- The FKBP12‐Rapamycin‐associated protein (FRAP) is a CLIP‐170 kinase
- Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor
- Molecular characterization of a plant FKBP12 that does not mediate action of FK506 and Rapamycin
- Synergistic effect of Rapamycin and cyclosporin A in the treatment of experimental autoimmune uveoretinitis.
- Rapamycin-insensitive regulation of 4e-BP1 in regenerating rat liver
- Tuberous sclerosis complex-1 and-2 gene products function together to inhibit mammalian target of Rapamycin (mTOR)-mediated downstream signaling
- Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and Rapamycin-sensitive PI 3-kinase …
- Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of Rapamycin sensitive signaling
- Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, Rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase …
- cAMP-and Rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells
- A Rapamycin-selective 25-kDa immunophilin
- FKBP12‐Rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol‐4 kinase activity.
- Pharmacokinetics and safety of single oral doses of sirolimus (Rapamycin) in healthy male volunteers
- Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and Rapamycin in 3T3-L1 adipocytes: evidence for the involvement …
- The TOR (target of Rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae
- Heat capacity changes and hydrophobic interactions in the binding of FK506 and Rapamycin to the FK506 binding protein
- Attenuation of mammalian target of Rapamycin activity by increased cAMP in 3T3-L1 adipocytes
- Rapamycin specifically interferes with the developmental response of fission yeast to starvation.
- CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant Rapamycin.
- Incorporation of acetate, propionate, and methionine into Rapamycin by Streptomyces hygroscopicus
- … Virus 1 Envelope Glycoprotein Complex-induced Apoptosis Involves Mammalian Target of Rapamycin/FKBP12-Rapamycin–associated Protein–mediated p53 …
- The efficacy and toxicity of Rapamycin in murine islet transplantation. In vitro and in vivo studies.
- Rapamycin partially prevents insulin resistance induced by chronic insulin treatment
- Rapamycin potentiates transforming growth factor β-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells
- Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (Rapamycin), mycophenolate mofetil and leflunomide
- Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex
- Prolongation of renal allograft survival in a large animal model by oral Rapamycin monotherapy.
- The effect of a high‐fat meal on the oral bioavailability of the immunosuppressant sirolimus (Rapamycin)
- Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of Rapamycin-dependent manner
- SIROLIMUS (Rapamycin) HALTS AND REVERSES PROGRESSION OF ALLOGRAFT VASCULAR DISEASE IN NON-HUMAN PRIMATES1
- The isolation, synthesis and characterization of an isomeric form of Rapamycin
- Effects of cyclosporin, FK506, and Rapamycin on graft-vessel disease
- … translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin: role of mammalian target of Rapamycin, protein kinase b, and …
- Rapamycin inhibition of interleukin-2-dependent p33cdk2 and p34cdc2 kinase activation in T lymphocytes.
- A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-DemethoxyRapamycin: Assembly of the Common C (1− 20) Perimeter and Final …
- Mechanism of the combination immunosuppressive effects of Rapamycin with either cyclosporine or tacrolimus
- The antimicrobial activities of cyclosporine, FK506, and Rapamycin
- Molecular cloning of a membrane-associated human FK506-and Rapamycin-binding protein, FKBP-13.
- Contrasting impacts of immunosuppressive agents (Rapamycin, FK506, cyclosporin A, and dexamethasone) on bidirectional dendritic cell-T cell interaction during …
- … new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12: prevention by the immunosuppressant drugs FK506 and Rapamycin
- Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and Rapamycin in man and rat.
- Rapamycin Inhibits α1-Adrenergic Receptor–Stimulated Cardiac Myocyte Hypertrophy but Not Activation of Hypertrophy-Associated Genes: Evidence for Involvement …
- FK506 and Rapamycin: novel pharmacological probes of the immune response
- Target of Rapamycin
- Mutagenesis of the Rapamycin producer Streptomyces hygroscopicus FC904
- The effect of Rapamycin on T cell development in mice
- The effects of Rapamycin in murine peripheral nerve isografts and allografts
- 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to Rapamycin
- A putative sirolimus (Rapamycin) effector protein
- Rapamycin: In Vitro Profile of a New Immunosuppressive Macrolide.
- The Upregulation of p27Kip1 by Rapamycin Results in G1 Arrest in Exponentially Growing T-Cell Lines
- Generation of novel Rapamycin structures by microbial manipulations
- Consensus guidelines for therapeutic drug monitoring of Rapamycin: report of the consensus panel
- Comparative study of cyclosporine and tacrolimus vs newer immunosuppressants mycophenolate mofetil and Rapamycin on coronary endothelial function
- Convergence of the target of Rapamycin and the Snf1 protein kinase pathways in the regulation of the subcellular localization of Msn2, a transcriptional …
- FKBP-Rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.
- Neointimal formation after balloon-induced vascular injury in Yucatan minipigs is reduced by oral Rapamycin
- Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by Rapamycin-insensitive pathways in skeletal muscle …
- Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and Rapamycin
- Studies on the chemistry of Rapamycin: novel transformations under Lewis-acid catalysis
- Rapamycin on trial
- Effects of Rapamycin on cultured hepatocyte proliferation and gene expression
- Therapeutic monitoring of Rapamycin: a new immunosuppressive drug.
- Chlamydia trachomatis Mip‐like protein has peptidylprolyl cis/trans isomerase activity that is inhibited by FK506 and Rapamycin and is implicated in initiation of …
- MID1 and MID2 homo-and heterodimerise to tether the Rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical …
- Rapamycin (sirolimus) inhibits proliferating cell nuclear antigen expression and blocks cell cycle in the G1 phase in human keratinocyte stem cells.
- Rapamycin prevents the onset of insulin‐dependent diabetes mellitus (IDDM) in NOD mice
- Sensitive and specific quantification of sirolimus (Rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry
- … LYMPHOCYTES MAY DISTINGUISH CYCLOSPORINE EFFECT IN RENAL TRANSPLANT RECIPIENTS RECEIVING A CYCLOSPORINE+ Rapamycin REGIMEN1
- Rapamycin, a potential disease-modifying antiarthritic drug.
- The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a Rapamycin-sensitive point immediately …
- Myogenic differentiation is dependent on both the kinase function and the N-terminal sequence of mammalian target of Rapamycin
- Treatment of autoimmune uveoretinitis in the rat with Rapamycin, an inhibitor of lymphocyte growth factor signal transduction
- Rapamycin, a potent immunosuppressive drug for vascularized heart, kidney, and small bowel transplantation in the rat.
- lnterleukin-2-mediated elimination of the p27 Kipl cyclin-dependent kinase inhibitor prevented by Rapamycin
- Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and Rapamycin
- Ultraviolet-induced phosphorylation of p70S6K at Thr389 and Thr421/Ser424 involves hydrogen peroxide and mammalian target of Rapamycin but not Akt and atypical …
- Toxicity of Rapamycin–a comparative and combination study with cyclosporine at immunotherapeutic dosage in the rat.
- L-Asparaginase inhibits the Rapamycin-targeted signaling pathway
- The Rapamycin and FKBP12 target (RAFT) displays phosphatidylinositol 4-kinase activity
- The Target of Rapamycin Signaling Pathway Regulates mRNA Turnover in the Yeast Saccharomyces cerevisiae
- Protein kinase activity and identification of a toxic effector domain of the target of Rapamycin TOR proteins in yeast
- inhibition of in vitro immunoglobulin production by Rapamycin.
- Rapamycin inhibits corneal allograft rejection and neovascularization
- Base catalyzed degradations of Rapamycin
- Rapamycin inhibits the generation of graft-versus-host disease-and graft-versus-leukemia-causing T cells by interfering with the production of Th1 or Th1 cytotoxic …
- The immunosuppressive macrolides FK-506 and Rapamycin act as reciprocal antagonists in murine T cells.
- Rapamycin: FK506’s fraternal twin or distant cousin?
- Substrate specificity for the human rotamase FKBP: a view of FK506 and Rapamycin as leucine-(twisted amide)-proline mimics
- Structure-activity studies of Rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP …
- Rapamycin reduces hybridoma cell death and enhances monoclonal antibody production
- A novel FK506-and Rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus.
- p70s6k integrates phosphatidylinositol 3-kinase and Rapamycin-regulated signals for E2F regulation in T lymphocytes
- DIFFERENTIAL EFFECTS OF CYCLOSPORINE A, METHYLPREDNISOLONE, MYCOPHENOLATE, AND Rapamycin ON CD154 INDUCTION AND REQUIREMENT …
- Target of Rapamycin proteins and their kinase activities are required for meiosis
- Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line.
- inhibition by Rapamycin of PDGF-and bFGF-induced human tenon fibroblast proliferation in vitro.
- New process control strategy used in a Rapamycin fermentation
- Tacrolimus-Rapamycin combination therapy for experimental autoimmune uveoretinitis
- Serotonin Activates S6 Kinase in a Rapamycin-Sensitive Manner inAplysia Synaptosomes
- A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of Rapamycin in mitogen-stimulated and transformed cells
- Insulin regulates lipoprotein lipase activity in rat adipose cells via wortmannin-and Rapamycin-sensitive pathways
- Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to Rapamycin biosynthesis
- Constitutive activation of S6 kinase by deletion of amino-terminal autoinhibitory and Rapamycin sensitivity domains.
- Growth of Streptomyces hygroscopicus in rotating-wall bioreactor under simulated microgravity inhibits Rapamycin production
- Structure of Rapamycin: an NMR and molecular‐dynamics investigation
- 40-O-(2-Hydroxyethyl)-Rapamycin Attenuates Pulmonary Arterial Hypertension and Neointimal Formation in Rats
- The Drosophila p70s6k homolog exhibits conserved regulatory elements and Rapamycin sensitivity
- Structure-activity studies of nonmacrocyclic Rapamycin derivatives
- Gene disruption and replacement in the Rapamycin-producing Streptomyces hygroscopicus strain ATCC 29253
- Production of synergistic but nonidentical mechanisms of immunosuppression by Rapamycin and cyclosporine.
- A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-DemethoxyRapamycin: Construction of the C (21− 42) Perimeters
- Design and Synthesis of a Rapamycin-based high affinity binding FKBP12 ligand
- Synthetic investigations of Rapamycin. 2. Synthesis of a C (22)-C (42) fragment
- The immunosuppressant Rapamycin, alone or with transforming growth factor-b, enhances osteoclast differentiation of RAW264. 7 monocyte-macrophage cells in the …
- Origin and true nature of the starter unit for the Rapamycin polyketide synthase
- … , p70 S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of Rapamycin (mTOR) pathway in the …
- Impaired phosphate handling of renal allografts is aggravated under Rapamycin‐based immunosuppression
- … in stereochemical communication: a strategy for the stereospecific synthesis and stabilization of the triene substructure of Rapamycin through sulfone substitution
- TACROLIMUS (FK506) AND SIROLIMUS (Rapamycin) IN COMBINATION ARE NOT ANTAGONISTIC BUT PRODUCE EXTENDED GRAFT SURVIVAL IN CARDIAC …
- Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and Rapamycin.
- Raf/MAPK and Rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells
- Rapamycin INDUCES TRANSFORMING GROWTH FACTOR-β PRODUCTION BY LYMPHOCYTES1
- Insulin release and suppression by tacrolimus, Rapamycin and cyclosporin A are through regulation of the ATP‐sensitive potassium channel
- … kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by Rapamycin: evidence that wortmannin …
- The Pipecolate‐Incorporating Enzyme for the Biosynthesis of the Immunosuppressant Rapamycin—Nucleotide Sequence Analysis, Disruption and Heterologous …
- Graft-versus-host disease prevention by Rapamycin: cellular mechanisms
- Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and Rapamycin …
- Quantitative analysis of sirolimus (Rapamycin) in blood by high-performance liquid chromatography–electrospray tandem mass spectrometry
- Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and Rapamycin.
- Isolation of two immunosuppressive metabolites after in vitro metabolism of Rapamycin.
- p-Glycoprotein-mediated transport of a fluorescent Rapamycin derivative in renal proximal tubule
- Expression, enzyme activity, and subcellular localization of mammalian target of Rapamycin in insulin-responsive cells
- Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is Rapamycin-sensitive and requires phosphatidylinositol 3-kinase
- Rapamycin blocks IL-2-driven T cell cycle progression while preserving T cell survival
- Molecular cloning of a 25-kDa high affinity Rapamycin binding protein, FKBP25.
- The immediate precursor of the nitrogen-containing ring of Rapamycin is free pipecolic acid
- Cholestasis and regulation of genes related to drug metabolism and biliary transport in rat liver following treatment with cyclosporine A and sirolimus (Rapamycin)
- A novel ring contraction of Rapamycin
- Prolongation of canine pancreatic islet allograft survival with combined Rapamycin and cyclosporine therapy at low doses. Rapamycin efficacy is blood level related.
- inhibition of liver, kidney, and intestine regeneration by Rapamycin
- Ig receptor binding protein 1 (α4) is associated with a Rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein …
- … of the International Society for Heart and Lung Transplantation working formulation for heart transplant biopsy specimens. Rapamycin Cardiac Rejection Treatment …
- Effect of Rapamycin on the cyclosporin A–resistant CD28-mediated costimulatory pathway
- Lack of change of cancellous bone volume with short-term use of the new immunosuppressant Rapamycin in rats
- Studies towards the total synthesis of Rapamycin: A convergent and stereoselective synthesis of the C22 C32 carbon framework
- Rapamycin and wortmannin enhance replication of a defective encephalomyocarditis virus
- … factor and its transcriptional activator, hypoxia inducible factor-1α, through a pathway involving phosphoinositide 3-kinase and the mammalian target of Rapamycin
- … acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by Rapamycin, and is independent …
- Effect of p27 deficiency and Rapamycin on intimal hyperplasia: in vivo and in vitro studies using a p27 knockout mouse model
- The effect of dexamethasone, cyclosporine, and Rapamycin on T-lymphocyte proliferation in vitro: comparison of cells from patients with glucocorticoid-sensitive and …
- Rapamycin increases the cellular concentration of the BCL-2 protein and exerts an anti-apoptotic effect
- Complete amino acid sequence of the FK506 and Rapamycin binding protein, FKBP, isolated from calf thymus
- Effects of Rapamycin, cyclosporin A, and dexamethasone on interleukin 5‐induced eosinophil degranulation and prolonged survival
- Microbial conversion of Rapamycin
- Therapeutic blood levels of sirolimus (Rapamycin) in the allografted rat
- Effect of Rapamycin on the expression of the IL‐2 receptor (CD25)
- Rapamycin inhibits transplant vasculopathy in long-surviving rat heart allografts.
- β-Agonists regulate Na, K-ATPase via novel MAPK/ERK and Rapamycin-sensitive pathways
- Assessment of cell‐signaling pathways in the regulation of mammalian target of Rapamycin (mTOR) by amino acids in rat adipocytes
- Beneficial effects of cyclosporine and Rapamycin in small bowel ischemic injury
- Routine clinical monitoring of sirolimus (Rapamycin) whole-blood concentrations by HPLC with ultraviolet detection
- inhibition by Rapamycin of P‐glycoprotein 170‐mediated export from normal lymphocytes
- Sample clean-up and high-performance liquid chromatographic techniques for measurement of whole blood Rapamycin concentrations
- THE METABOLIC IMPACT OF Rapamycin (SIROLIMUS) IN CHRONIC CANINE ISLET GRAFT RECIPIENTS1
- Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes.
- Dominant mutations confer resistance to the immunosuppressant, Rapamycin, in variants of a T cell lymphoma
- Effects of cyclosporine and Rapamycin on immunoglobulin production by preactivated human B cells
- Facile synthesis of the “tricarbonyl” subunit in the immunosuppressant Rapamycin
- Effects of FK506 and Rapamycin on excitation‐contraction coupling in skeletal muscle fibres of the rat.
- Involvement of a Rapamycin-sensitive pathway in CD40-mediated activation of murine B cells in vitro
- Degradation of Rapamycin: synthesis of a Rapamycin derived fragment containing the tricarbonyl and triene sectors
- Calcineurin inhibitor‐induced chronic nephrotoxicity in liver transplant patients is reversible using Rapamycin as the primary immunosuppressive agent
- EFFECT OF TACROLIMUS (FK506) AND SIROLIMUS (Rapamycin) MONO-AND COMBINATION THERAPY IN PROLONGATION OF RENAL ALLOGRAFT …
- Efficacy of Rapamycin and FK 506 in prolonging rat hind limb allograft survival.
- Distinct repression of translation by wortmannin and Rapamycin
- Evidence that Rapamycin inhibits interleukin-12-induced proliferation of activated T lymphocytes.
- Determination of Rapamycin in whole blood by HPLC
- Total synthesis of Rapamycin
- Rapamycin inhibits p34cdc2 expression and arrests T lymphocyte proliferation at the G1/S transition.
- Uncoupling p70s6 kinase activation and proliferation: Rapamycin-resistant proliferation of human CD8+ T lymphocytes
- Exogenous shikimic acid stimulates Rapamycin biosynthesis inStreptomyces hygroscopicus
- Ryanodine receptors from rabbit skeletal muscle are reversibly activated by Rapamycin
- Synthetic studies toward Rapamycin: a solution to a problem in chirality merger through use of the Ireland reaction
- The nature of the starter unit for the Rapamycin polyketide synthase
- Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (Rapamycin)
- Proinflammatory effects in experimental mesangial proliferative glomerulonephritis of the immunosuppressive agent SDZ RAD, a Rapamycin derivative
- USE OF ANTI-CD25 MONOCLONAL ANTIBODY IN COMBINATION WITH Rapamycin TO ELIMINATE CYCLOSPORINE TREATMENT DURING THE INDUCTION …
- Loss of ypk1 function causes Rapamycin sensitivity, inhibition of translation initiation and synthetic lethality in 14-3-3-deficient yeast
- Acute effects of Rapamycin on glomerular dynamics: a micropuncture study in the rat
- Cyclosporine, FK506, and Rapamycin. Some effects on early activation events in serum-free, mitogen-stimulated mouse spleen cells.
- The cyclohexane moiety of Rapamycin is derived from shikimic acid in Streptomyces hygroscopicus
- Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of Rapamycin but develop an …
- In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: comparison with Rapamycin
- Degradative studies on the tricarbonyl containing macrolide Rapamycin
- The potential role of Rapamycin in pediatric transplantation as observed from adult studies
- Comparison of the effects of FK-506, cyclosporin A and Rapamycin on IL-2 production.
- Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the Rapamycin-insensitive site (serine-111)
- The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and Rapamycin.
- Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells
- Effect of Rapamycin on rat aortic ring vasomotion.
- … cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of Rapamycin
- Rapamycin blocks sexual development in fission yeast through inhibition of the cellular function of an FKBP12 homolog
- Simultaneous on-line extraction and analysis of sirolimus (Rapamycin) and ciclosporin in blood by liquid chromatography–electrospray mass spectrometry
- Both Rapamycin-sensitive and-insensitive pathways are involved in the phosphorylation of the initiation factor-4E-binding protein (4E-BP1) in response to insulin in rat …
- Compared to mycophenolate mofetil, Rapamycin induces significant changes on growth factors and growth factor receptors in the early days postkidney …
- Mammalian RAFT1 kinase domain provides Rapamycin-sensitive TOR function in yeast.
- Conversion from liquid to solid Rapamycin formulations in stable renal allograft transplant recipients
- Secretion of FK506/FK520 and Rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans
- Side effects of Rapamycin in the rat
- The effect of Rapamycin on single ENaC channel activity and phosphorylation in A6 cells
- Rapamycin (Sirolimus) inhibits vascular smooth muscle DNA synthesis in vitro and suppresses narrowing in arterial allografts and in balloon-injured carotid arteries …
- Measurement of Rapamycin in whole blood using reverse-phase high-performance liquid chromatography.
- Regulation of the Rapamycin and FKBP-target 1/mammalian target of Rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase
- Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection.
- Two discrete regions of interleukin-2 (IL2) receptor β independently mediate IL2 activation of a PD98059/Rapamycin/wortmannin-insensitive Stat5a/b serine …
- The tyrosine89 residue of yeast FKBP12 is required for Rapamycin binding
- Assignment of the human FKBP12-Rapamycin-associated protein (FRAP) gene to chromosome 1p36 by fluorescence in situ hybridization
- Rapamycin, but not FK506 and GPI-1046, increases neurite outgrowth in PC12 cells by inhibiting cell cycle progression
- Rapamycin: personal algorithms for use based on 250 treated renal allograft recipients.
- Rapamycin INHIBITS DEVELOPMENT OF OBLITERATIVE AIRWAY DISEASE IN A MURINE HETEROTOPIC AIRWAY TRANSPLANT MODEL1
- The immunosuppressant Rapamycin blocks in vitro responses to hematopoietic cytokines and inhibits recovering but not steady-state hematopoiesis in vivo
- Estrogen and Rapamycin effects on cell cycle progression in T47D breast cancer cells
- The effects of the immunosuppressant Rapamycin on the growth of rheumatoid arthritis (RA) synovial fibroblast
- Deletion of rapQONML from the Rapamycin gene cluster of Streptomyces hygroscopicus gives production of the 16-O-desmethyl-27-desmethoxy analog
- Rapamycin may prevent post-transplant lymphoma
- … π-face selectivity in anti aldol reactions of E-enol borinates from chiral alkoxymethyl ketones: stereocontrolled synthesis of a C24-C32 polyol subunit of Rapamycin
- … of MAP kinases, pp90rsk and pp70‐S6 kinases in mouse mast cells by signaling through the c‐kit receptor tyrosine kinase or FcϵRI: Rapamycin inhibits activation of …
- Intramolecular hydrogen transfer reactions of o-(bromophenyl) dialkylsilyl ethers. Preparation of Rapamycin-d1
- … 3-kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of Rapamycin, Ly294002, and wortmannin on …
- Rapamycin dissociates p70S6K activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells
- Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells
- Rapamycin: immunosuppression, hyporesponsiveness, and side effects in a porcine renal allograft model.
- Effect of cyclosporine, mycophenolic acid, and Rapamycin on the proliferation of rat aortic vascular smooth muscle cells: in vitro study
- Single-channel activity of the Ca2+-dependent K+ channel is modulated by FK506 and Rapamycin
- Use of Rapamycin for the suppression of alloimmune reactions in vivo: schedule dependence, tolerance induction, synergy with cyclosporine and FK 506, and effect on …
- Failure of Rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase
- Rapamycin inhibits proteasome activator expression and proteasome activity
- ASSOCIATION OF GLUCOCORTICOIDS AND CYCLOSPORIN A OR Rapamycin PREVENTS E-SELECTIN AND IL-8 EXPRESSION DURING LPS-AND TNFα …
- The zinc finger protein GLI induces cellular sensitivity to the mTOR inhibitor Rapamycin
- Sirolimus (Rapamycin) in clinical transplantation
- Rapamycin inhibits didemnin B‐induced apoptosis in human HL‐60 cells: Evidence for the possible involvement of FK506‐binding protein 25
- Siloxanes: versatile templates for acyclic stereocontrol. Synthesis of the C27-C33 segment of Rapamycin
- Dose-dependent pharmacokinetics of Rapamycin-28-N,N-dimethylglycinate in the mouse
- Interstitial pneumonitis associated with sirolimus (Rapamycin) therapy after liver transplantation
- The relationship of blood concentrations of Rapamycin and cyclosporine to suppression of allograft rejection in a rabbit heterotopic heart transplant model.
- … -severe combined immunodeficient (HuPBL-SCID) mouse/skin allograft model is T cell mediated and inhibited by a combination of cyclosporine and Rapamycin
- … hydration contributions to the thermodynamics of ligand binding by proteins. Enthalpy and heat capacity changes of tacrolimus and Rapamycin binding to FK506 …
- Selective epimerization of Rapamycin via a retroaldol/aldol mechanism mediated by titanium tetraisopropoxide
- inhibition of proliferation but not erythroid differentiation of J2E cells by Rapamycin
- The 14-3-3 proteins positively regulate Rapamycin-sensitive signaling
- Systemic toxicity following administration of sirolimus (formerly Rapamycin) for psoriasis: association of capillary leak syndrome with apoptosis of lesional lymphocytes
- Oral administration of Rapamycin and cyclosporine differentially alter intestinal function in rabbits
- p70 S6 kinase sensitivity to Rapamycin is eliminated by amino acid substitution of Thr229.
- High‐Sensitivity sequencing of large proteins: Partial structure of the Rapamycin‐fkbp12 target
- Renal effects of Rapamycin in the spontaneously hypertensive rat
- Effects of immunosuppressants FK506 and Rapamycin on the heterooligomeric form of the progesterone receptor
- Sirolimus (Rapamycin, Rapamune®) and combination therapy with cyclosporin A in the rat developing adjuvant arthritis model: correlation with blood levels and the …
- The effect of Rapamycin on renal function in the rat: a comparative study with cyclosporine
- Efficient Removal of Pipecolinate from Rapamycin and FK506 by Reaction with n-Bu4N+ CN−
- Rapamycin resistance in ataxia-telangiectasia.
- Regulation of ribosomal S6 kinase 2 by mammalian target of Rapamycin
- Induction of differentiation of human myeloid leukemia cells by immunosuppressant macrolides (Rapamycin and FK506) and calcium/calmodulin-dependent kinase …
- Lipophilic benzamide and anilide derivatives as high-performance liquid chromatography internal standards: application to sirolimus (Rapamycin) determination
- Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with Rapamycin
- … by insulin and insulin-like growth factor-I: glycogen synthase activation is antagonized by wortmannin or LY294002 but not by Rapamycin or by inhibiting …
- Pharmacokinetics of Rapamycin: single-dose studies in the rabbit.
- Preferential production of Rapamycin vs prolylRapamycin by Streptomyces hygroscopicus
- Successful myoblast allotransplantation in mdx mice using Rapamycin
- A second type-I PKS gene cluster isolated from Streptomyces hygroscopicus ATCC 29253, a Rapamycin-producing strain
- Pediatric utilization of Rapamycin for severe cardiac allograft rejection
- An application of the suárez reaction to the regiospecific and stereospecific synthesis of the C28-C42 segment of Rapamycin
- Immunopharmacology of Rapamycin
- Manipulation of the Rapamycin effector domain. selective nucleophilic substitution of the C7 methoxy group
- High performance liquid chromatographic isolation, spectroscopic characterization, and immunosuppressive activities of two Rapamycin degradation products
- Antifungal Rapamycin analogues with reduced immunosuppressive activity
- … localization of the human α4/IGBP1 gene, the structure of which is closely related to the yeast TAP42 protein of the Rapamycin-sensitive signal transduction pathway
- Antagonistic roles for CTLA-4 and the mammalian target of Rapamycin in the regulation of clonal anergy: enhanced cell cycle progression promotes recall antigen …
- inhibition by Rapamycin of ornithine decarboxylase and epithelial cell proliferation in intestinal IEC‐6 cells in culture
- Insulin stimulation of muscle protein synthesis in obese Zucker rats is not via a Rapamycin-sensitive pathway
- Stability of sirolimus (Rapamycin) in whole blood
- Automated simultaneous quantification of the immunosuppressants 40-O-(2-hydroxyethyl)Rapamycin and cyclosporine in blood with electrospray-mass spectrometric …
- Cytokine and alloantibody networks in long term cardiac allografts in rat recipients treated with Rapamycin.
- FK506 and Rapamycin modulate the functional activities of human peripheral blood eosinophils
- Sirolimus (Rapamycin) potentiates cyclosporine in prevention of acute lung rejection
- Rapamycin potentiates dexamethasone-induced apoptosis and inhibits JNK activity in lymphoblastoid cells
- FAP1, a homologue of human transcription factor NF‐X1, competes with Rapamycin for binding to FKBP12 in yeast
- Rapamycin destabilizes interleukin-3 mRNA in autocrine tumor cells by a mechanism requiring an intact 3’untranslated region.
- Effect of Rapamycin on morphological and functional parameters in the kidney of the rabbit
- Synthetic investigations of Rapamycin. 1. Synthesis of a C10-C21 fragment
- Suppression of acute rejection in allogeneic rat lung transplantation: a study of the efficacy and pharmacokinetics of Rapamycin derivative (SDZ RAD) used alone and …
- Proton and nitrogen sequential assignments and secondary structure determination of the human FK506 and Rapamycin binding protein
- Abrogation by Rapamycin of accelerated rejection in sensitized rats by inhibition of alloantibody responses and selective suppression of intragraft mononuclear and …
- FK506 binding protein 12 mediates sensitivity to both FK506 and Rapamycin in murine mast cells
- Post-translational reduction of cell surface expression of insulin receptors by cyclosporin A, FK506 and Rapamycin in bovine adrenal chromaffin cells
- Antiproliferative effect of Rapamycin on growth factor-stimulated human adult lung fibroblasts in vitro may explain its superior efficacy for prevention and treatment of …
- Effects of the combination of Rapamycin with tacrolimus or cyclosporin on experimental intimal hyperplasia
- Anisomycin and Rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction.
- Rapamycin inhibits production of cytotoxic but not noncytotoxic antibodies and preferentially activates T helper 2 cells that mediate long-term survival of heart …
- Studies towards the total synthesis of Rapamycin: Preparation of the C10 C17 carbon unit
- Effects of Rapamycin on apoptosis of rheumatoid synovial cells
- Rapamycin and T cell costimulatory blockade as post-transplant treatment promote fully MHC-mismatched allogeneic bone marrow engraftment under …
- Mean field analysis of FKBP12 complexes with FK506 and Rapamycin: Implications for a role of crystallographic water molecules in molecular recognition and …
- Effects of immunosuppressive peptidyl-prolyl cis-trans isomerase (PPIase) inhibitors, cyclosporin A, FK506, ascomycin and Rapamycin, on hair growth initiation in …
- High performance liquid chromatographic isolation and spectroscopic characterization of three major metabolites from the plasma of rats receiving Rapamycin …
- Implication of alpha4 phosphoprotein and the Rapamycin-sensitive mammalian target-of-Rapamycin pathway in prolactin receptor signalling
- Effects of Rapamycin on human HLA-unrestricted cell killing
- cDNA Cloning of a human 5 kDa FK506 and Rapamycin binding protein
- Identification of a new metabolite of macrolide immunosuppressant, like Rapamycin and SDZ RAD, using high performance liquid chromatography and electrospray …
- Evidence that Rapamycin has differential effects of IL-4 function. Multiple IL-4 signaling pathways and implications for in vivo use.
- Calcium/calmodulin kinase inhibitors and immunosuppressant macrolides Rapamycin and FK506 inhibit progestin-and glucocorticosteroid receptor-mediated …
- CsA, FK506, corticosteroids and Rapamycin inhibit TNFα production by cultured PTEC
- Augmentation of SR Ca2+ release by Rapamycin and FK506 causes K+‐channel activation and membrane hyperpolarization in bladder smooth muscle
- Dihydroxylation of the triene subunit of Rapamycin
- Rituximab and Rapamycin for posttransplant lymphoproliferative disease treatment: report of three cases
- Effect of single-dose Rapamycin-based immunosuppression on the development of cardiac allograft vasculopathy.
- Rapamycin, FK506 and cyclosporin A inhibit human prolactin gene expression
- The immunomodulatory drugs cyclosporin A, mycophenolate mofetil, and sirolimus (Rapamycin) inhibit allergen-induced proliferation and IL-5 production by PBMCs …
- Rapamycin selectively blocks interleukin-2-induced proliferating cell nuclear antigen gene expression in T lymphocyte: evidence for inhibition of CREB/ATF …
- Rapamycin treatment depresses intragraft expression of KC/MIP-2, granzyme B, and IFN-gamma in rat recipients of cardiac allografts.
- Reversal of ongoing heart, kidney, and pancreas allograft rejection and suppression of accelerated heart allograft rejection in the rat by Rapamycin.
- Glucocorticoid-induced insulin resistance of protein synthesis is independent of the Rapamycin-sensitive pathways in rat skeletal muscle
- Long-term in vivo effects of Rapamycin on humoral and cellular immune responses in the rat
- … signals that control cell proliferation in mammalian balance epithelia: key roles for phosphatidylinositol-3 kinase, mammalian target of Rapamycin, and S6 kinases in …
- Rapamycin, a potent inhibitor of T-cell function, prevents graft rejection in murine recipients of allogeneic T-cell-depleted donor marrow [published erratum appears in …
- Immunosuppressant Rapamycin inhibits protein kinase C α and p38 mitogen-activated protein kinase leading to the inhibition of chondrogenesis
- FK506 and Rapamycin selectively enhance degradation of IL-2 and GM-CSF mRNA.
- THE IMMUNOSUPPRESSIVE EFFECT OF Rapamycin ON MOUSE SMALL BOWEL TRANSPLANTATION1
- Studies on selective reductions of Rapamycin
- Rapamycin: biological and therapeutic effects, binding by immunophilins and molecular targets of action
- PHARMACOKINETICS AND TOLERABILITY OF 40–0-[2-HYDROXYETHYL] Rapamycin IN DE NOVO LIVER TRANSPLANT RECIPIENTS1
- The synergistic interactions in vitro and in vivo of brequinar sodium with cyclosporine or Rapamycin alone and in triple combination.
- The future role of target of Rapamycin inhibitors in renal transplantation
- Rapamycin-induced long-term allograft survival depends on persistence of alloantigen.
- Effects of Rapamycin on renal hemodynamics, water and sodium excretion, and plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide, and vasopressin …
- Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (Rapamycin) by electrospray-MS/MS after …
- Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant Rapamycin.
- Comparison of the effect of Rapamycin and FK506 on release of prostacyclin and endothelin in vitro
- A nonimmunosuppressive triene-modified Rapamycin analog is a potent inhibitor of peptidyl prolyl cis-trans-isomerase
- Cleavage of the cyclohexyl-subunit of Rapamycin results in loss of immunosuppressive activity
- A high performance liquid chromatographic method for the determination of Rapamycin (sirolimus) in rat serum, plasma, and blood and in monkey serum
- Cyclosporin A, FK506, Rapamycin: the use of a quantitative analytic tool to discriminate immunosuppressive drug interactions.
- Quantitative comparison of Rapamycin and cyclosporine effects on cytokine gene expression studied by reverse transcriptase-competitive polymerase chain reaction.
- Methionine Interference in Rapamycin Production Involves Repression of DemethylRapamycin Methyltransferase andS-Adenosylmethionine Synthetase
- A highly convergent strategy towards Rapamycin. Stereoselective construction of the C 8–C 18 fragment
- FK506 and Rapamycin binding to FKBP: Common elements in immunophilin-ligand complexation
- Cloning and sequence analysis of a Rapamycin-binding protein-encoding gene (RBP1) from Candida albicans
- Functional and histopathologic effects of Rapamycin on mouse kidney
- Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent Rapamycin
- Structural basis for peptidomimicry by the effector element of Rapamycin
- Involvement of the Rapamycin-sensitive pathway in the insulin regulation of muscle protein synthesis in streptozotocin-diabetic rats
- COADMINISTRATION OF NEORAL AND THE NOVEL Rapamycin ANALOG, SDZ RAD, TO RAT LUNG ALLOGRAFT RECIPIENTS: Potentiation of …
- Efficacies of sirolimus (Rapamycin) and cyclosporine in allograft vascular disease in non-human primates: trough levels of sirolimus correlate with inhibition of …
- ADJUNCTIVE Rapamycin AND CsA TREATMENT INHIBITS MONOCYTE/MACROPHAGE ASSOCIATED CYTOKINES/CHEMOKINES IN SENSITIZED CARDIAC …
- Rapamycin (sirolimus) inhibits heart cell growth in vitro
- Rapamycin‐resistant phosphorylation of the initiation factor‐4E‐binding protein (4E‐BP1) in v‐SRC‐transformed hamster fibroblasts
- Acid catalyzed functionalization of Rapamycin
- Discordant effects of Rapamycin on proliferation and p70S6 kinase phosphorylation in normal and neoplastic rat chromaffin cells
- Missense mutations at the FKBP12-Rapamycin-binding site of TOR1
- Nutritional and intestinal effects of the novel immunosuppressive agents: deoxyspergualin, Rapamycin, and mycophenolate mofetil
- Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells
- inhibition by Rapamycin of leukocyte migration and bronchial hyperreactivity induced by injection of Sephadex beads to guinea‐pigs
- The RB/p107/p130 phosphorylation pathway is not inhibited in Rapamycin-induced G1-prolongation of NIH3T3 cells.
- The mechanism of unresponsiveness to allografts induced by Rapamycin and Rapamycin/cyclosporine treatment in rats.
- Calorimetric measurements of the complexation of cyclosporin A, ascomycin, fujimycin, and Rapamycin with lithium chloride and with an immunophilin
- ANALYSIS OF FUNCTIONAL RENAL ALLOGRAFT TOLERANCE WITH SINGLE-DOSE Rapamycin BASED INDUCTION IMMUNOSUPPRESSION1
- Genetic relationships among actinomycetes that produce the immunosuppressant macrolides FK506, FK520/FK523 and Rapamycin
- Rapamycin inhibits IL-1-mediated interferon-gamma production in the YAC-1 T cell lymphoma
- Rapamycin inhibits airway leukocyte infiltration and hyperreactivity in guinea pigs
- Synthetic approaches to Rapamycin
- Synthesis of the Tricarbonyl Subunit (C8−C19) of Rapamycin via Tandem Chan Rearrangement−Oxidation
- Rapamycin synthetic studies. 2. Elaboration of the C (10)-C (26) perimeter
- Use of Rapamycin in a transplant patient who developed cyclosporin neurotoxicity
- Prolactin and insulin synergize to regulate the translation modulator PHAS-I via mitogen-activated protein kinase-independent but wortmannin-and Rapamycin …
- Manipulation of the C (22)-C (27) region of Rapamycin: stability issues and biological implications
- Opposing effects of Rapamycin and cyclosporin A on activation-induced Ca2+ release
- Detection of noncovalent FKBP-FK506 and FKBP-Rapamycin complexes by capillary electrophoresis-mass spectrometry and capillary electrophoresis-tandem mass …
- Comparative effects of Rapamycin FK 506 and cyclosporine on antibody production, lymphocyte populations and immunoglobulin isotype switching in the rat
- Rapamycin insensitivity in Schistosoma mansoni is not due to FKBP12 functionality
- Lipase mediated hydrolysis of Rapamycin 42-hemisuccinate benzyl and methyl esters
- The effect of the immunophilin ligands Rapamycin and FK506 on proliferation of mast cells and other hematopoietic cell lines.
- Rapamycin: A new and highly active immunosuppressive macrolide with an efficacy superior to cyclosporine
- Effect of a short course of Rapamycin, cyclosporin A, and donor-specific transfusion on rat cardiac allograft survival.
- Cyclosporin A, FK506 and Rapamycin produce multiple, temporally distinct, effects on memory following single-trial, passive avoidance training in the chick
- Effect of Rapamycin on renal allograft survival in canine recipients treated with antilymphocyte serum, donor bone marrow, and cyclosporine.
- Synthesis of I‐125 labeled photoaffinity Rapamycin analogs
- Interleukin 4-inducible phosphorylation of HMG-I (Y) is inhibited by Rapamycin
- inhibition of CTL induction by Rapamycin: IL-2 rescues granzyme B and perforin expression but only partially restores cytotoxic activity.
- Effects of cyclosporin A, Rapamycin, and FK520 on peripheral T-cell deletion and anergy
- The effect of cyclosporin A, FK506 and Rapamycin on the murine contact sensitivity reaction
- Structure of FKBP12. 6 in complex with Rapamycin
- SUPERIORITY OF SIROLIMUS (Rapamycin) OVER CYCLOSPORINE IN AUGMENTING ALLOGRAFT AND XENOGRAFT SURVIVAL IN MICE TREATED WITH …
- Rapamycin but not FK506 inhibits the proliferation of mononuclear phagocytes induced by colony-stimulating factors
- inhibition of host-versus-graft and graft-versus-host responses after small bowel transplantation in rats by Rapamycin.
- Rapamycin and FK506 differentially inhibit mast cell cytokine production and cytokine-induced proliferation and act as reciprocal antagonists.
- DETERMINATION OF AN IMPROVED SIROLIMUS (Rapamycin)-BASED REGIMEN FOR INDUCTION OF ALLOGRAFT TOLERANCE IN MICE TREATED WITH …
- Structure of the human 25 kDa FK506 binding protein complexed with Rapamycin
- The effects of Rapamycin on humoral immunity in vivo. Suppression of primary responses but not of ongoing alloantibody synthesis or memory responses.
- Hypersensitivity to Rapamycin of BJAB B lymphoblastoid cells.
- … IMMUNOMODULATION LEADS TO ENHANCED ALLOGRAFT SURVIVAL IN COMBINATION WITH CYCLOSPORINE A AND Rapamycin, BUT NOT FK5061
- The effect of Rapamycin on c-jun expression in human lymphocytes
- Tritium labelling of RAD001—a new Rapamycin derivative
- Relationship between multiple biologic effects of Rapamycin and the inhibition of pp70S6 protein kinase activity. Analysis in mutant clones of a T cell lymphoma.
- In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by Rapamycin leads to a clinical-pathological syndrome discrete from that …
- Rapamycin Prolongs Survival of Murine Recipients of Fully Allogeneic Donor Grafts When Administered during the Graft‐versus‐Host Disease Process a
- Isolation and identification of new Rapamycin dihydrodiol metabolites from dexamethasoneinduced rat liver microsomes
- Rapamycin and FK506 induce long-term potentiation by pairing stimulation via an intracellular Ca2+ signaling mechanism in rat hippocampal CA1 neurons
- … triamcinolone acetonide accumulation in mouse fibroblasts is differently modulated by the immunosuppressants cyclosporin A, FK506, Rapamycin and their analogues …
- … C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of Rapamycin …
- Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of Rapamycin, but independent of …
- Conformational changes of Rapamycin and analogs upon complexing with FKBP associated with activity: an application of second derivative CD spectroscopy
- inhibition of S6 Kinase by Rapamycin Blocks Maturation ofRana dybowskiiOocytes
- Reversible isomerization of Rapamycin demonstrated by liquid chromatography
- The human gene encoding FKBP-Rapamycin associated protein (FRAP) maps to chromosomal band 1p36. 2
- Studies towards the total synthesis of Rapamycin: Preparation of the cyclohexyl C33 C42 fragment and further coupling to afford the C22 C42 carbon unit
- The effect of anti‐IL‐4 monoclonal antibody, Rapamycin and interferon‐γ on airway hyperreactivity to acetylcholine in mice
- IL-2 induces beta2-integrin adhesion via a wortmannin/LY294002-sensitive, Rapamycin-resistant pathway. Phosphorylation of a 125-kilodalton protein correlates with …
- Biochemical and structural studies of the FK506-and Rapamycin-binding proteins (FKBPs).
- Rapamycin-sensitive phosphorylation of ribosomal protein S17 by p70 S6 kinase
- Differential inhibition of cutaneous T-cell-mediated reactions and epidermal cell proliferation by cyclosporin A, FK-506, and Rapamycin
- Cyclosporine and Rapamycin affect protein kinase C induction of the intracellular activation signal, activator of DNA replication.
- The effect of cyclosporin A, FK506, and Rapamycin on the murine chronic graft‐versus‐host response—an in vivo model of Th2‐like activity
- Efficacy of Rapamycin, RS-61443 and cyclophosphamide in the prolongation of survival of discordant pig to rabbit cardiac xenografts.
- Rapamycin graft pretreatment in small bowel and kidney transplantation in the rat.
- Left main Rapamycin-coated stent: Invasive versus noninvasive angiographic follow-up
- Investigation of Rapamycin transport and uptake across absorptive human intestinal cell monolayers
- Effects of wortmannin and Rapamycin on CSF-1-mediated responses in macrophages
- Cyclosporin A, Rapamycin and FK506 decrease prolactin release from rat pituitary cells in primary culture
- Sirolimus: mammalian target of Rapamycin inhibitor to prevent kidney rejection
- Hepatotrophic properties in dogs of human FKBP, the binding protein for FK506 and Rapamycin
- Up-regulation of cell surface sodium channels by cyclosporin A, FK506, and Rapamycin in adrenal chromaffin cells
- Synergistic effect of Rapamycin and cyclosporine in prevention of acute kidney allograft rejection in the mouse
- Isolation of a human cDNA encoding a 25 kDa FK-506 and Rapamycin binding protein
- Suppression of allograft responses by combining alloantigen-specific iv pre-sensitization with suboptimal doses of Rapamycin
- Rapamycin
- Comparison of binding characteristics of four Rapamycin metabolites to the 14 and 52 kDa immunophilins with their pharmacologic activity measured by the mixed …
- Hemolytic uremic syndrome after renal transplantation: immunosuppressive therapy with Rapamycin
- Immunosuppressants FK506 and Rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation
- Inducible membrane recruitment of small GTP-binding proteins by Rapamycin-based system in living cells
- Intragraft cytokine expressionf in tolerant rat renal allografts with Rapamycin and cyclosporin immunosuppression
- Evidence that Rapamycin rescue therapy delays rejection of major (MHC) plus minor (non-MHC) histoincompatible heart allografts in rats.
- Ethanol potentiates the stimulatory effects of insulin and phosphocholine on mitogenesis by a zinc-dependent and Rapamycin-sensitive mechanism in fibroblasts and …
- … CD8+ T cells tolerized in vivo: employing a model of Ld-specific TCR transgenic mice transplanted with allogenic hearts under the cover of a short-term Rapamycin …
- Insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of Rapamycin (mTOR) signalling is impaired …
- Saccharomyces cerevisiae contains a homolog of human fkbp‐13, a membrane‐associated fk506/Rapamycin binding protein
- An unexpected inhibitory effect of Rapamycin against germination of spores of Bacillus brevis strain Nagano
- Identification of a 14 kDa FK-506/Rapamycin binding immunophilin from calf thymus
- … –electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl) Rapamycin
- Rapamycin inhibits activation of ryanodine receptors from skeletal muscle by the fatty acyl CoA–acyl CoA binding protein complex
- Exclusion of the 13-kDa Rapamycin binding protein gene (FKBP2) as a candidate gene for multiple endocrine neoplasia type 1
- Towards the synthesis of the C37-C42 fragment of Rapamycin: intramolecular reactions of allyl silanes with oxonium ions generated from α-alkoxy sulfones.
- Quantitative and temporal analysis of the cellular interaction of FK-506 and Rapamycin in T-lymphocytes.
- … ARE NOT REQUIRED FOR INDUCTION OF ALLOGRAFT TOLERANCE IN MICE TREATED WITH ANTILYMPHOCYTE SERUM, Rapamycin, AND DONOR BONE …
- A comparison of the effects of Rapamycin and cyclosporine on kidney and heart morphology in a rabbit heterotopic heart transplant model
- Murine TRAIL (TNF-related apoptosis inducing ligand) expression induced by T cell activation is blocked by Rapamycin, cyclosporin A, and inhibitors of …
- Cyclosporine, FK-506, Rapamycin, and other immunomodulators
- Rapamycin INDUCES TGF-β PRODUCTION IN LYMPOCYTES
- Marked prolongation of rat skin xenografts induced by intrathymic injection of xenogeneic splenocytes and a short course of Rapamycin in antilymphocyte serum …
- inhibition of cellular transfer of experimental autoimmune uveoretinitis by Rapamycin
- Rapamycin: a future in cancer treatment?
- Reduction of Sephadex-induced lung inflammation and bronchial hyperreactivity by Rapamycin.
- K+ currents responsible for repolarization in mouse ventricle and their modulation by FK-506 and Rapamycin
- 14-3-3τ associates with a translational control factor FKBP12-Rapamycin-associated protein in T-cells after stimulation by pervanadate
- IL-2-dependent induction of G1 cyclins in primary T cells is not blocked by Rapamycin or cyclosporin A
- Evidence that FK506 and Rapamycin block T cell activation at different sites relative to early reversible phosphorylation involving the protein phosphatases PP1 and …
- Partial characterization of a 52 kDa CsA/FK506/Rapamycin binding protein
- Rapamycin: Therapeutic range investigations
- Brief treatment with Rapamycin in vivo increases responsiveness to alloantigens measured by the mixed lymphocyte response
- Anti-CD2 monoclonal antibodies synergize with FK506 but not with cyclosporine or Rapamycin to induce tolerance.
- Up-regulation of insulin-like growth factor binding protein-5 is independent of muscle cell differentiation, sensitive to Rapamycin, but insensitive to wortmannin and …
- The effect of cyclosporine, Rapamycin and FK 506 the survival following allogeneic bone marrow transplantation
- Treatment of normal skeletal muscle with FK506 or Rapamycin results in halothane-induced muscle contracture
- EFFECT OF IN VIVO Rapamycin TREATMENT ON DE NOVO T-CELL DEVELOPMENT IN RELATION TO INDUCTION OF AUTOIMMUNE-LIKE …
- Swinging the vote for Rapamycin
- Activation of 70‐kDa S6 kinase, induced by the cytokines interleukin‐3 and erythropoietin and inhibited by Rapamycin, is not an absolute requirement for cell …
- Rapamycin increases transforming growth factor-β mRNA expression in immortalized rat proximal renal tubular cells
- Divergent effects of Rapamycin on mouse and rat cells following mitogenic stimulation
- Differential effects of the immunosuppressive macrolides FK-506 and Rapamycin on activation-induced T-cell apoptosis
- Induction of tolerance to skin allografts by intrathymic injection of donor splenocytes. Effect of donor-recipient strain combination and supplemental Rapamycin.
- Isolation and identification of a C39 demethylated metabolite of Rapamycin from pig liver microsomes and evaluation of its immunosuppressive activity
- … from pig liver microsomes, identification by electrospray tandem mass spectrometry and in vitro immunosuppressive activity of a Rapamycin tris‐epoxide metabolite
- Ionization of the c7 methoxy group in Rapamycin by 5 M lithium perchlorate-diethyl ether
- Induction of CD5 on B and T cells is suppressed by cyclosporin A, FK-520 and Rapamycin
- Mammalian target of Rapamycin: Immunosuppressive drugs offer new insights into cell growth regulation
- Rapamycin-induced apoptosis is p53-independent in human prostate carcinoma PC-3 cells
- Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and Rapamycin
- Stereoselective construction of the C 21–C 42 fragment of Rapamycin
- Rapamycin FOR REFRACTORY RENAL ALLOGRAFT REJECTION.
- C‐14 labelling of NVP RAD001—a new Rapamycin derivative
- The immunosuppressive macrolides FK-506 and Rapamycin
- Inhibitors of mammalian target of Rapamycin
- inhibition of the Mr 70,000 S6 kinase pathway by Rapamycin results in chromosome malsegregation in yeast and mammalian cells
- Possible involvement of Rapamycin-sensitive pathway in Bcl-2 expression in human neuroblastoma SH-SY5Y cells
- Ionizing radiation enhances double-strand-break repair in Rapamycin-treated ataxia telangiectasia lymphoblasts
- Effect of Rapamycin on prolactin-stimulated S6 kinase activity and milk product formation in mouse mammary explants
- Differential effect of Rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2
- A short-term combination therapy with cyclosporine and Rapamycin or leflunomide induces long-term heart allograft survival in a strongly immunogenic strain …
- FK-506 and Rapamycin but not cyclosporin inhibit aldosterone-stimulated sodium transport in A6 cells
- FK506 and Rapamycin: Differential sensitivity of human, baboon, cynomolgus monkey, dog and pig lymphocytes
- Late adjunctive therapy with single doses of Rapamycin in skin-allografted mice treated with antilymphocyte serum and donor bone marrow cells
- Rapamycin inhibits substance P-induced protein synthesis and phosphorylation of PHAS-I (4E-BP1) and p70 S6 kinase (p70 (S6K)) in human astrocytoma cells
- … peptide corresponding to residues 65–79 of an HLA class II sequence: functional similarities but mechanistic differences with the immunosuppressive drug Rapamycin
- Synthesis and bioactivity of photolabile sirolimus (Rapamycin) analogs
- Rapamycin for GVHD prophylaxis-potential for severe myelotoxicity
- Provocative effects of the immunosuppressants Rapamycin, tacrolimus, and dexamethasone on Pneumocystis carinii pneumonitis in contrast to the anti-Pneumocystis …
- Comparative effects of FK-506, Rapamycin and cyclosporin A, on the in vitro differentiation of dorsal root ganglia explants and septal cholinergic neurons
- Anti‐CD28 antibody‐and IL‐4‐induced human T cell proliferation is sensitive to Rapamycin
- Rapamycin inhibits aldolase A expression during human lymphocyte activation
- The effects of FK 506, cyclosporine, and Rapamycin on liver growth in vitro and in vivo
- Analogous conformations of both binding and effector regions in cyclosporin A, FK506 and Rapamycin
- X-ray Crystal Structure of 28-O-MethylRapamycin complexed with FKBP12: Is the Cyclohexyl Moiety Part of the Effector Domain of Rapamycin?
- Rapamycin, cyclosporine, and perioperative donor-specific transfusions induce prolongation of cardiac allograft survival in the rat.
- Structure-activity relationships involving modifications to the macrolides FK-506 and Rapamycin
- Comparative study of CSA and FK506 versus newer immunosuppressive drugs MMF and Rapamycin on coronary endothelial function in vitro
- PHAS-I phosphorylation in response to foetal bovine serum (FBS) is regulated by an ERK1/ERK2-independent and Rapamycin-sensitive pathway in 3T3-L1 …
- Structural analysis of Rapamycin and related compounds using [M + Li]+ ions generated by liquid secondary ion mass spectrometry
- The gene structure and promoter analysis of mouse lymphocyte signal transduction molecule α4 that is related to the yeast TAP42 involved in a Rapamycin-sensitive …
- The transcriptional profile of Saccharomyces cerevisiae exposed to Rapamycin mimics the profile induced by amino acid starvation
- … with chiral homoallylic ethers: An application to the asymmetric synthesis od (11R, 14S)-anti-and (31R, 34S)-syn-segements of immunosuppressant Rapamycin
- SAFETY AND PHARMACOKINETIC PROFILE OF ASCENDING SINGLE DOSES OF ORAL LIQUID SIROLIMUS (Rapamycin) IN PEDIATRIC PATIENTS WITH STABLE …
- … suppression of T cell responses to minor histocompatibility antigens by chloroquine in combination with tacrolimus and a Rapamycin derivative, SDZ-RAD
- … factor β1 inhibits interleukin‐1‐induced but enhances ionomycin‐induced interferon‐γ production in at cell lymphoma: Comparison with the effects of Rapamycin
- Long-term viability of articular cartilage after microsurgical whole-joint transplantation and immunosuppression with Rapamycin, mycophenolate mofetil, and tacrolimus
- Effect of cyclosporin A, Rapamycin, and FK-506 on corneal epithelial cells and lymphocyte proliferation
- Comparative in vitro studies on the immunosuppressive activities of mycophenolic acid, bredinin, FK 506, cyclosporine, and Rapamycin
- Responsiveness of preactivated B cells to IL-2 and IL-6. Effect of cyclosporine and Rapamycin.
- Differential effects of cyclosporin-A and Rapamycin on in vivo thymocyte maturation
- Immunopharmacology of Rapamycin (A review)
- Synergism between corticosteroids and Rapamycin for the treatment of intraocular inflammation
- Rapamycin induces binding activity to the terminal oligopyrimidine tract of ribosomal protein mRNA in rats
- Intrasplenic liver parenchymal cells in conjunction with low-dose Rapamycin and cyclosporine induce a unique and specific prolongation of rat cardiac and small bowel …
- Target of Rapamycin (TOR) signaling coordinates tRNA and 5S rRNA gene transcription with growth rate in yeast
- HPLC Analysis of Rapamycin
- TGF-beta Provides the Rationale for the Synergistic Immunpsuppression with Rapamycin (RAPA), Cyclosporine (CsA) and Tacrolimus (TAC)
- Pharmacokinetic and pharmacodynamic correlations of cyclosporine (CsA) and Rapamycin (RAPA) in 120 patients treated for at least 2 years at a single center.
- Effects of mycophenolic acid, Rapamycin, and carvedilol on the PDGF-induced fibronectin secretion by rat vascular smooth muscle cells: Implication of MAP kinase
- The Effect of Immunosuppressive Agents (FK‐506, Rapamycin) on Renal P450 Systems in Rat Models
- A comparison of in vivo responses to cyclosporine, FK506, and Rapamycin following allogeneic immune challenge
- Rapamycin inhibits the in vitro release of soluble CD23 by SAC/IL-2/IL-4-activated human peripheral blood B lymphocytes
- Comparison of FK‐506, Rapamycin, Ascomycin, and Cyclosporine in Mouse Models of Host‐versus‐Graft Disease and Heterotopic Heart Transplantation
- Generation and evaluation of putative neuroregenerative drugs: Part 2: Screening virtual libraries of novel polyketides which possess the binding domain of Rapamycin
- Steroids, Rapamycin, and breast cancer cells.
- ADDITION OF Rapamycin TO CYCLOSPORINE-PREDNISONE BASED IMMUNOSUPPRESSION REDUCES THE CLINICAL RISK OF PRETRANSPLANT ANTI …
- Rapamycin treatment depresses
- Osmotic pump delivery of Rapamycin
- An open-label multi-center clinical study of the efficacy and safety of Rapamycin in combination with CsA and steroid to prevent the acute rejection of kidney …
- inhibition of anti-CD3 antibody-induced mouse T cell activation by pentoxifylline in combination with Rapamycin or A77 1726 (leflunomide)
- Prevention of cardiac allograft rejection by FK506 and Rapamycin: assessment by histology and nuclear magnetic resonance
- Induction of IL-5 expression by IL-2 is resistant to the immunosuppressive agents cyclosporin A and Rapamycin.
- Rapamycin inhibits the in vitro release of soluble interleukin-2 receptor by activated peripheral blood mononuclear cells (PBMC) independently of the mode of …
- Rapamycin (Sirolimus) reduces luminal narrowing after balloon angioplasty in porcine coronary arteries
- The Rapamycin sensitivity of human T-cell leukaemia virus type I-induced T-cell proliferation is mediated independently of the polypyrimidine motifs in the 5′ long …
- Signaling Pathways for Translation: Stress, Calcium, and Rapamycin
- Rapamycin and reduced dose cyclosporin produce effective immunosuppression for de novo renal transplant recipients
- Differentiation by Rapamycin
- Generation and evaluation of putative neuroregenerative drugs: Part 1: virtual point mutations to the polyketide Rapamycin
- Triglyceride (TG) elevations in renal transplant recipients treated with sirolimus (Rapamycin, RAPA) added to a cyclosporine (CsA)/prednisone (pred) regimen
- Rapamycin: a new immunosuppressive agent capable of inhibiting chronic rejection?
- Effects of Rapamycin and FK 506 on Rat Sertoli Cells In Vitro
- The Immunosuppressant Rapamycin Induces Inactivation
- Effect of immunosuppressants FK506 and Rapamycin on the function of progesterone receptor: protein” p59-HBI”, intersection between immunology and endocrinology …
- Effects of Rapamycin on the proliferation and the prodution of IL-2, IFN-γ, TNF-α of spleniclymphocytes in mice [J]
- Rapamycin-inducible Secretion of a Therapeutic Protein in the Eye After Transduction With Viral Vectors
- High performance liquid chromatographic isolation and spectroscopic characterization of metabolites from the bile of rats receiving Rapamycin (sirolimus) …
- In vitro IgE production by interleukin 4-stimulated human peripheral blood mononuclear cells is suppressed by Rapamycin
- Conformational sensitivity analysis of FKBP–FK506/Rapamycin complexes
- Rapamycin (sirolimus, RapamuneTM): A novel immunosuppressive agent
- Cytokine expression in a stringent, single-dose Rapamycin, renal allograft model
- Induction of Rapamycin sensitivity by the Gli oncogene.
- Conversion from cyclosporine to Rapamycin in renal transplant recipients-Report of an initial experience.
- IL-2 DEPENDENT Rapamycin RESISTENT SIGNALS ARE REQUIRED FOR TOLERANCE INDUCTION AND T CELL APOPTOSIS
- Supercritical fluid chromatography for therapeutic drug monitoring of immunosuppressants: selectivity for cyclosporine A, FK 506 (tacrolimus), and Rapamycin
- Total syntheses of Rapamycin and 32-(S)-dihydroRapamycin.
- Rapamycin does not improve renal function or reduce profibrotic gene expression in chronic allograft nephropathy
- THE Rapamycin ANALOGUE SDZ RAD INHIBITS LPS AND ANTI-CD3mAb INDUCED IL-10 SYNTHESIS IN VITRO AND IN HUMAN RENAL ALLOGRAFT …
- Studies directed towards the synthesis of Rapamycin
- Choosing rational combinations of therapeutic agents: Contrasting effects of costimulation blockade plus Rapamycin or cyclosporin on intragraft expression of …
- Effects of FK506 and Rapamycin on formation of the neural tube in chick embryos
- Increased LFA-1-mediated homotypic cell adhesion is associated with the G1 growth arrest induced by Rapamycin in a T cell lymphoma
- The biosynthesis of Rapamycin
- Studies towards the total synthesis of Rapamycin
- FOUR-YEAR CONTROL OF A CLINICAL Rapamycin ASSAY
- Control of translation by a novel, Rapamycin-sensitive signaling pathway.
- The total synthesis of (-)-Rapamycin
- Total synthesis of Rapamycin.
- Rapamycin inhibits HMGB1 expression and releases in RAW264. 7 cells induced by lipopolysaccharides in vitro
- Effects of Rapamycin and insulin on the cell cycle and apoptosis of hybridoma cell cultures
- Rapamycin inhibits proliferating cell nuclear antigen expression and arrests keratinocytes in the G 1 phase of the cell cycle in vitro.
- The Immunophilin Ligand Rapamycin: A Probe for the Analysis of the Relationship of Apoptosis to the Cell Cycle
- Comparison between effects of mycophenolate mofetil and Rapamycin on proliferation and apoptosis of cyst-lining epithelial cells of ADPKD patients
- Synthetic methods directed towards the synthesis of Rapamycin.
- … ALLOGRAFT NEPHROPATHY: A PROSPECTIVE RANDOMISED TRIAL OF CYCLOSPORIN REDUCTION WITH OR WITHOUT Rapamycin.: Abstract# 432 Poster …
- Methionine Interference in Rapamycin
- Evaluation of the Influence of FK 506, Rapamycin, and Cyclosporine on Processing and Presentation of Particulate Antigen by Macrophages: Assessment of a …
- Sirolimus (Rapamycin) monotherapy prevents graft vascular disease in non-human primates
- Use of anti-CD25 monoclonal antibody in combination with Rapamycin to reduce or eliminate cyclosporine treatment during the induction phase of …
- Efficacy of 40-O-(2-hydroxyethyl)-Rapamycin in preventing chronic renal allograft rejection in rats
- Effect of cyclosporin A, FK506 and Rapamycin on proliferation and soluble IL-2 receptor release from mitogenically stimulated rat spleen cells
- Coadministered neoral and the new Rapamycin derivative, SDZ RAD, for nonhuman primate lung transplantation: systematic pharmcokinetic-based trials to maximize …
- Effects of Rapamycin on number and activity of endothelial progenitor cells
- Total Synthesis of Rapamycin
- Rapamycin has no effect on established allograft vasculopathy
- Total Synthesis of Rapamycin
- Therapeutic monitoring of cyclosporine, FK-506, and Rapamycin
- Insensitivity towards inhibition by cyclosporin A, Rapamycin and tacrolimus in human intestinal lamina propria T lymphocytes
- Cyclosporine but not Rapamycin stimulates endothelin-1 secretion by endothelial cells: Potential significance in transplant vasculopathy
- Rapamycin RESCUE IN PEDIATRIC LIVER RECIPIENTS WITH TACROLIMUS TOXICITY. A PRELIMINARY EFFECT: CONCENTRATION ANALYSIS.: Abstract# 210 …
- Studies towards the total synthesis of Rapamycin
- Inhibitory Effects of Rapamycin on the Experimental Allograft Rejection
- Innovative technique for immunosuppresion involving administration of Rapamycin loaded formed blood elements
- Regulation and identification of Rapamycin sensitive phosphorylation sites of p70s6k
- Studies directed toward the synthesis of the southern fragment of Rapamycin
- Inhibitors of Mammalian Target of Rapamycin
- Effect of Rapamycin on allograft rejection and immune response in mice
- In vitro and in vivo assessment of Rapamycin as an immunosuppressive agent in the rabbit
- Synthetic studies on the C10-C17 fragment of Rapamycin
- Effects of Rapamycin on the proliferation and the prodution of IL-2, IFN-?, TNF-? of spleniclymphocytes in mice
- Synergism between corticosteroids and Rapamycin for the treatment of intraocular inflammation
- Rapamycin and C (27)-demethoxyRapamycin: An efficient stereocontrolled synthesis of the C (1)-C (20) and C (22)-C (26) fragments.
- The effect of Rapamycin in prologation of adrenal allograft survival in the rat
- inhibition of cellular transfer of experimental autoimmune uveoretinitis by Rapamycin
- Rapamycin and other natural products affect regulation of the growth and differentiation of Saccharomyces cerevisiae.
- Biosynthesis of Rapamycin by streptomyces hygroscopicus
- Rapamycin, FRAP and the Control of 5’TOP mRNA Translation
- Synergistic effects of mycophenolate mofetil (MMF) and sirolimus (Rapamycin, RAPA) in prevention of acute heart, pancreas and kidney allograft rejection and in …
- Therapeutic window of whole blood Rapamycin concentration in recipients of renal transplantation
- Syntheses and biological activities of natural products: Rapamycin, balanol and the maduropeptin chromophore.
- The immunosuppressive effect of Rapamycin on lymphocytic proliferation and DTH, GVHR
- Risk factors for Rapamycin-induced thrombocytopenia and leukopenia in renal transplant recipients
- Immunosuppressive effect of Rapamycin on heart allotransplantation in the rat [J]
- The effect of soy protein on serum lipids in kidney transplant patients receiving Rapamycin.
- Aberrant expression of mammalian target of Rapamycin in stage ⅢB colon cancer and its significance
- Rapamycin Inhibits 3T3-L1 Adipocyte Differentiation Independent of Clonal Expansion
- Effect of Rapamycin on the cyclosporin A-resistant CD28-mediated
- Synthetic approaches to the tricarbonyl subunit of Rapamycin
- Molecular mechanisms of action of the immunosuppressive drugs cyclosporin A, FK506 and Rapamycin.
- Effects of Rapamycin on chronic nephrotoxicity induced by cyclosporine A in rats
- Rapamycin antagonizes interleukin-6 mediated growth arrest and differentiation of myeloblastic M1 cells
- Cyclin D3, a key cyclin in human lymphocyte proliferation and Rapamycin-mediated immunosuppression.
- EXTREME HYPERLIPIDEMIA RESULTING FROM Rapamycin-DERIVED DRUG ADMINISTRATION.: Abstract# 827 Poster Board#-Session: P84-III
- Siloxanes as templates in asymmetric synthesis: Studies directed towards the synthesis of Rapamycin.
- FK 506 versus cyclosponne a for steroid-free synergistic combination therapy with Rapamycin in a discordant large animal donor xenoislet transplant model
- Studies of the Rapamycin-sensitive signaling network using genomics, chemical genetics, and small molecule microarrays.
- Rapamycin increases the expression of genes responsible for extracellular matrix remodelling compared to neoral in rat allografts
- Inhibitory effects of Rapamycin on intimal hyperplasia after PTCA in the porcine coronary model: a 3-month follow-up
- Regulation of the cell integrity pathway by Rapamycin-sensitive TOR function in budding yeast
- Rapamycin Inhibits Estrogen-Mediated Transcription in Breast Cancer Cell Lines
- Tissue Distribution of Rapamycin and Cyclosporine in the Rat: Comparison of Single vs. Dual Drug Therapy
- inhibition by Rapamycin of PDGF-and bFGF-induced human tenon fibroblast proliferation in vitro
- Effects of Rapamycin and wortmannin on the insulin stimulation of protein synthesis in rat skeletal muscle and L6 myoblasts
- The expression of mammalian target of Rapamycin in autogenous vein graft in rats
- The Effects of Immunosuppressants Rapamycin and Cyclosporin A on the Proliferation, Cell Cycle, and Cyclin Expression of Cultured Human Keratinocyte Cell Line …
- The effects of Rapamycin and cyclosporin a on tolerance induction through bone marrow transplantation with costimulation blockade
- Cyclosporin and FK506, but not Rapamycin, increase DNFB induced TNF-alpha expression in human epidermal sheets.
- Mass spectrometric analysis of the Rapamycin-dependent phosphorylation sites of the yeast protein kinase NPR1
- Effects of stent-based delivery of Rapamycin and methotrexate on neointimal formation in a porcine coronary model
- Effects of cyclosporin and Rapamycin on the in vitro activation of human CD8+ lymphocytes in comparison with peripheral blood mononuclear cells.
- Evaluation of Rapamycin coated stents by multi row detector computed angiography: comparison to quantitative angiographic results
- Cyclosporin A and FK506, but not Rapamycin, increase DNFB induced TNF-alpha expression in human epidermal sheets.
- Using natural products to elucidate molecular events within cells: Molecular mechanisms of action of cyclosporine, FK506, and Rapamycin.
- SDZ-RAD PREVENTS CYCLOSPORINE-INDUCED inhibition OF BRAIN ENERGY METABOLISM: COMPARISON WITH Rapamycin.: Abstract# 314 Poster Board …
- Rapamycin POTENTIATES NF-κB AND AP-1 ACTIVATION IN TNF-α TREATED PRIMARY RAT HEPATOCYTES.: Abstract# 308 Poster Board#-Session: P155-I
- The Mechanism of Insulin-Induced Clonal Expansion in Adipocyte Differentiation–the Importance of PI3 Kinae-Rapamycin-Sensitive Pathway
- Inhibitory effects of Rapamycin and ascomycin on hair growth induced by cyclosporin A and FK506 in mice.
- Effects of Rapamycin-treated HSP60-pulsed dendritic cells on the progression of the atherosclerotic plaque in mice
- inhibition of S6 Kinase by Rapamycin Blocks Maturation of Rana dybowskii Oocytes
- Relationship between multiple biological effects of Rapamycin and the inhibition of pp70 S6 protein kinase activity: Analysis in mutant clones of a T cell lymphoma.
- The study of Rapamycin-eluting polymer-coated stents to prevent restenosis in the porcine coronary injury model
- Differential effects of cyclosporine and Rapamycin on costimulation blockade induced allograft tolerance: Intragraft CTL gene expression analysis
- BRIEF COMMUNICATIONS: EFFECT OF Rapamycin ON RENAL ALLOGRAFT SURVIVAL IN CANINE RECIPIENTS TREATED WITH ANTILYMPHOCYTE SERUM …
- Rapamycin RESCUE IN PEDIATRIC LIVER RECIPIENTS WITH TACROLIMUS TOXICITY.: Abstract# 211 Poster Board#-Session: P58-I
- Rapamycin (RAPA) lowers dose requirements of cyclosporin (CsA) in renal transplant patients (RTx)
- … Lewis acid-mediated Mukaiyama aldol reaction of α-alkoxythiolketene acetals with α, β-disubstituted enals: synthesis of the C26–C33 segment of Rapamycin
- Rapamycin selectively inhibits translation of mRNAs encoding elongation factor and ribosomal protein
- FK506 versus CSA for steroid-free synergistic combination therapy with Rapamycin (Rapa) in a discordant xenoislet model
- SHORT TERM ANTILYMPHOCYTE SERUM, Rapamycin AND DONOR BONE MARROW SIGNIFICANTLY SUPPRESS ANTIDONOR ANTIBODY AND PROLONG …
- … studies n bioactive natural products. Part I, An approach towards the nootrophic agent huperzine A. Part II, Synthesis of the tricarbonyl subunit of Rapamycin
- EFFECT OF TACROLIMUS (FK506) AND SIROLIMUS (Rapamycin) MONO-AND COMBINATION THERAPY IN PROLONGATION OF RENAL ALLOGRAFT …
- Coadministration of neoral and the novel Rapamycin analog, sdzrad, to. lung allograft recipients: potentiation of immunosuppressive efficacy and reduction of toxicity …
- Rapamycin (Rapa) And Cyclosporin A (Csa) Enhance Transforming Growth Factor Beta (TGF-β1) Expression in Immortalized Rat Proximal Tubules (IRPTC)† 1840
- Rapamycin (RAPA) ENHANCES TRANSFORMING GROWTH FACTOR BETA (TGF-β1) EXPRESSION IN IMMORTALIZED RAT PROXIMAL TUBULES CELLS …
- Prevention of Arterial Restenosis by Rapamycin and Mycophenolate Mofetil: A New Role for Novel Immunosuppressants in the Prevention of Post-Balloon Angioplasty …
- Rapamycin synergizes with dst plus anti-CD154 to block auto and allo-immune response and induce islet allograft engraftment in spontaneous autoimmune diabetic …
- Mating stimulate protein phosphorylation and synthesis via Rapamycin-and wortmannin-sensitive manner in male accessory glands of D. melanogaster
- Combined use of mycophenolate mofetil (MMF) and Rapamycin (RAPA) in prevention of acute heart allograft rejection and reversal of ongoing cardiac allograft …
- Chronic Rejection in Non-human Primates: Sirolimus (Rapamycin), but not Cyclosporin, Prevents Graft Vascular Disease (GVD) in Aortic Allografts after Acute …
- Provocative effects of the immunosuppressants Rapamycin, tacrolimus, and dexamethasone on Pneumocystis carinii pneumonitis in contrast to the anti-Pneumocystis …
- Synthesis of the C-21-C-42 fragment of Rapamycin and total synthesis of Rapamycin.
- PMA Induced Ser/Thr Phosphorylation of IRS-1 Mediated by Rapamycin-Sensitive Pathway
- Desensitization of Insulin Action through Ser/Thr Phosphorylation and Degradation of IRS-1 by Activation of Rapamycin-Sensitive Pathway
- 24 HPLC (ESI)-MS IDENTIFICATION OF SIROLIMUS (Rapamycin) METABOLITES GENERATED IN A RABBIT MICROSOMAL SYSTEM AND CONFIRMATION WITH …
- Interleukin-2 and Rapamycin regulation of cyclin E-Cdk2 kinase, the Cdk inhibitor, P27KIP1, and the T lymphocyte cell cycle.
- 192 SENSITIVE AND SPECIFIC QUANTIFICATION OF SIROLIMUS (Rapamycin) AND ITS METABOLITES IN BLOOD AND URINE OF KIDNEY GRAFT RECIPIENTS …
- OP-4. Studies towards the Total Synthesis of Rapamycin
- 74 DETERMINATION OF Rapamycin IN WHOLE BLOOD BY HPLC
- # 680 In vitro evaluation of Rapamycin sensitivity and synergy with cisplatin and camptothecin in medulloblastoma
- Purification and characterization of a 50 kiloDalton lymphocyte-derived binding protein for cyclosporin, FK-506 and Rapamycin.
- … from carbohydrates: Application of the (2, 3)-Wittig rearrangement of carbohydrate-derived alpha-alkoxy tertiary allylic ethers to the syntheses of Adda and Rapamycin.
- Efficacy of FK-506 and Rapamycin in Prolongation of Allograft Rat Limb Survival
- # 764 Rapamycin effects phosphorylation of p70S6 kinase and other intermediaries in medulloblastoma
- I. The formal synthesis of FK-506. II. A simple synthesis of vicinal tricarbonyls. III. Studies toward the synthesis of Rapamycin.
- Glucose-induced polypyrimidine-tract-binding protein (PTB) to the 3´-untranslated region of the insulin mRNA is inhibited by Rapamycin
- METABOLISM AND PHARMACOKINETICS OF THE NEW IMMUNOSUPPRESSANT 40-O-(2-HYDROXY)-ETHYL-Rapamycin
- 138 Rapamycin AND CYCLOSPORINE DRUG STUDIES IN THE RAT MODEL
- Rapamycin: an anti-cancer immunosuppressant?
- Determinants of Rapamycin sensitivity in breast cancer cells
- Antileukemic activity of Rapamycin in acute myeloid leukemia
- Molecular organization of target of Rapamycin complex 2
- Rapamycin-induced oligospermia
- mTOR-targeted therapy of cancer with Rapamycin derivatives
- Rapamycin pre-treatment protects against apoptosis
- Activation of Akt and eIF4E survival pathways by Rapamycin-mediated mammalian target of Rapamycin inhibition
- Signaling by target of Rapamycin proteins in cell growth control
- Differential effects of Rapamycin on mammalian target of Rapamycin signaling functions in mammalian cells
- Rapamycin alleviates toxicity of different aggregate-prone proteins
- Prolonged Rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
- Rapamycin attenuates load-induced cardiac hypertrophy in mice
- Use of Rapamycin slows progression of cardiac transplantation vasculopathy
- Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease
- Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
- Rapamycin is an effective inhibitor of human renal cancer metastasis
- Maintenance immunosuppression with target-of-Rapamycin inhibitors is associated with a reduced incidence of de novo malignancies
- Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
- Campath‐1H induction plus Rapamycin monotherapy for renal transplantation: results of a pilot study
- Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 IsMediated by p70S6 Kinase
- Target of Rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
- Pathological angiogenesis is induced by sustained Akt signaling and inhibited by Rapamycin
- Characterization of the FKBP⊙ Rapamycin⊙ FRB Ternary Complex
- inhibition of target of Rapamycin signaling by Rapamycin in the unicellular green alga Chlamydomonas reinhardtii
- Insulin/IGF and target of Rapamycin signaling: a TOR de force in growth control
- Targeting the molecular target of Rapamycin (mTOR)
- inhibition of mTOR signaling with Rapamycin regresses established cardiac hypertrophy induced by pressure overload
- The molecular target of Rapamycin (mTOR) as a therapeutic target against cancer
- Regulation of adipocyte differentiation and insulin action with Rapamycin
- Effects of Rapamycin in the Eker rat model of tuberous sclerosis complex
- Targeting the mammalian target of Rapamycin (mTOR): a new approach to treating cancer
- Target of Rapamycin-mediated amino acid signaling in mosquito anautogeny
- Multiple roles of Tap42 in mediating Rapamycin-induced transcriptional changes in yeast
- Rapamycin impairs antigen uptake of human dendritic cells1
- Rapamycin-eluting stents for the treatment of bifurcated coronary lesions: a randomized comparison of a simple versus complex strategy
- Mammalian target of Rapamycin inhibition as therapy for hematologic malignancies
- Dissociation of raptor from mTOR is a mechanism of Rapamycin‐induced inhibition of mTOR function
- GβL, a positive regulator of the Rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
- Mammalian target of Rapamycin: a new molecular target for breast cancer
- Combination of Rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs
- A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of Rapamycin and its targets
- Immunosuppressants and skin cancer in transplant patients: focus on Rapamycin
- Rapamycin promotes expansion of functional CD4+ CD25+ FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients
- Specific binding to intracellular proteins determines arterial transport properties for Rapamycin and paclitaxel
- Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells
- Targeting mammalian target of Rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells
- Upstream of the mammalian target of Rapamycin: do all roads pass through mTOR?
- Rictor, a novel binding partner of mTOR, defines a Rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
- Phospholipase D confers Rapamycin resistance in human breast cancer cells
- Thr2446 is a novel mammalian target of Rapamycin (mTOR) phosphorylation site regulated by nutrient status
- Nephrotoxicity of Rapamycin: an emerging problem in clinical medicine
- Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity
- The mammalian target of Rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
- Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis
- Rapamycin reduces disease activity and normalizes T cell activation–induced calcium fluxing in patients with systemic lupus erythematosus
- Rapamycin suppresses experimental aortic aneurysm growth
- Rapamycin is active against B-precursor leukemia in vitro and in vivo, an effect that is modulated by IL-7-mediated signaling
- Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets
- Antiangiogenic potential of the mammalian target of Rapamycin inhibitor temsirolimus
- Mammalian TOR complex 2 controls the actin cytoskeleton and is Rapamycin insensitive
- Rapamycin protects allografts from rejection while simultaneously attacking tumors in immunosuppressed mice
- The Pim kinases control Rapamycin-resistant T cell survival and activation
- Akt activates the mammalian target of Rapamycin by regulating cellular ATP level and AMPK activity
- Mammalian target of Rapamycin, a molecular target in squamous cell carcinomas of the head and neck
- Finding new components of the target of Rapamycin (TOR) signaling network through chemical genetics and proteome chips
- Stent implantation activates RhoA in human arteries: inhibitory effect of Rapamycin
- Regulation of targets of mTOR (mammalian target of Rapamycin) signalling by intracellular amino acid availability.
- Rapamycin for treatment of chronic allograft nephropathy in renal transplant patients
- Sustained activation of the JNK cascade and Rapamycin-induced apoptosis are suppressed by p53/p21Cip1
- Combination of the mTOR inhibitor Rapamycin and CC-5013 has synergistic activity in multiple myeloma
- Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance
- Gene expression-based chemical genomics identifies Rapamycin as a modulator of MCL1 and glucocorticoid resistance
- Rapamycin activates Tap42‐associated phosphatases by abrogating their association with Tor complex 1
- Preliminary observations regarding angiographic pattern of restenosis after Rapamycin-eluting stent implantation
- Mutasynthesis of Rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis
- Curcumin inhibits the mammalian target of Rapamycin‐mediated signaling pathways in cancer cells
- Mammalian target of Rapamycin pathway blockade slows progression of diabetic kidney disease in rats
- The solution structure of the FATC domain of the protein kinase target of Rapamycin suggests a role for redox-dependent structural and cellular stability
- Mammalian target of Rapamycin regulates IRS-1 serine 307 phosphorylation
- The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of Rapamycin pathway
- Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells
- Insights into TOR function and Rapamycin response: chemical genomic profiling by using a high-density cell array method
- Survival signaling by Notch1: mammalian target of Rapamycin (mTOR)–dependent inhibition of p53
- Antitumoral activity of Rapamycin in renal angiomyolipoma associated with tuberous sclerosis complex
- Rapamycin successfully treats post‐transplant autoimmune hepatitis
- Increased activation of the mammalian target of Rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance
- Rapamycin: signaling in vascular smooth muscle
- Therapeutic potential of target of Rapamycin inhibitors
- Synergistic augmentation of Rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors
- Rapamycin inhibits proliferation and differentiation of human endothelial progenitor cells in vitro
- Rheb binding to mammalian target of Rapamycin (mTOR) is regulated by amino acid sufficiency
- Rapamycin-sensitive pathway regulates mitochondrial membrane potential, autophagy, and survival in irradiated MCF-7 cells
- Inhibitory effect of Rapamycin on corneal neovascularization in vitro and in vivo
- Regulation of peroxisome proliferator–activated receptor-γ activity by mammalian target of Rapamycin and amino acids in adipogenesis
- inhibition of mTOR signaling with Rapamycin attenuates renal hypertrophy in the early diabetic mice
- Identification of S6 kinase 1 as a novel mammalian target of Rapamycin (mTOR)-phosphorylating kinase
- Rapamycin inhibits IL-4—induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo
- Mammalian target of Rapamycin inhibition
- Phase I/II study of the mammalian target of Rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
- Mechanical stimuli regulate Rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B-and growth factor-independent mechanism
- Dosing of Rapamycin is critical to achieve an optimal antiangiogenic effect against cancer
- A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of Rapamycin (mTOR) signalling pathway
- Rapamycin induces tumor-specific thrombosis via tissue factor in the presence of VEGF
- Acute Rapamycin nephrotoxicity in native kidneys of patients with chronic glomerulopathies
- Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone
- AKT activity determines sensitivity to mammalian target of Rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression
- Inhibitors of the mammalian target of Rapamycin
- Homodirectional changes in transcriptome composition and mRNA translation induced by Rapamycin and heat shock
- Rapamycin, but not FK-506, increases endothelial tissue factor expression: implications for drug-eluting stent design
- Oral Rapamycin after coronary bare-metal stent implantation to prevent restenosis: the Prospective, Randomized Oral Rapamycin in Argentina (ORAR II) Study
- Rapamycin-mediated inhibition of mammalian target of Rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation
- Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
- Rapamycin inhibits the growth and metastatic progression of non-small cell lung cancer
- Effect of Rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer
- Efficacy of a Rapamycin analog (CCI‐779) and IFN‐γ in tuberous sclerosis mouse models
- Rapamycin confers preconditioning-like protection against ischemia–reperfusion injury in isolated mouse heart and cardiomyocytes
- Drosophila target of Rapamycin kinase functions as a multimer
- Targeting the Akt/mammalian target of Rapamycin pathway for radiosensitization of breast cancer
- A selective small molecule c-MET Inhibitor, PHA665752, cooperates with Rapamycin
- Arabidopsis TARGET OF Rapamycin interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals
- Rapamycin in cardiovascular medicine
- Mechanical stimuli and nutrients regulate Rapamycin‐sensitive signaling through distinct mechanisms in skeletal muscle
- FKBP12-Rapamycin-associated protein or mammalian target of Rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus
- S6K1−/−/S6K2−/− mice exhibit perinatal lethality and Rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein …
- Determinants of sensitivity and resistance to Rapamycin-chemotherapy drug combinations in vivo
- Brain-derived neurotrophic factor induces mammalian target of Rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal …
- In vitro study of release mechanisms of paclitaxel and Rapamycin from drug-incorporated biodegradable stent matrices
- The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of Rapamycin by amino acids and certain cellular stresses
- Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways
- Rapamycin‐sensitive signalling in long‐term consolidation of auditory cortex‐dependent memory
- Systemic Rapamycin inhibits retinal and choroidal neovascularization in mice
- inhibition of the mammalian target of Rapamycin (mTOR) by Rapamycin increases chemosensitivity of CaSki cells to paclitaxel
- Target of Rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of …
- Rapamycin‐treated, alloantigen‐pulsed host dendritic cells induce ag‐specific T cell regulation and prolong graft survival
- Activation of mammalian target of Rapamycin in cytomegalic neurons of human cortical dysplasia
- Mutation in TSC2 and activation of mammalian target of Rapamycin signalling pathway in renal angiomyolipoma
- inhibition of mammalian target of Rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cells
- Role of mammalian target of Rapamycin signaling in compensatory renal hypertrophy
- Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non–small-cell lung, pancreatic, colon, and breast tumors
- Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy
- Activation of the Akt/mammalian target of Rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers
- Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of Rapamycin signaling
- BDNF regulates the translation of a select group of mRNAs by a mammalian target of Rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal …
- Antitumor efficacy of intermittent treatment schedules with the Rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in …
- The mammalian target of Rapamycin signaling network and gene regulation
- Combination mammalian target of Rapamycin inhibitor Rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple …
- Role of glycogen synthase kinase 3β in Rapamycin-mediated cell cycle regulation and chemosensitivity
- Immediate response of mammalian target of Rapamycin (mTOR)‐mediated signalling following acute resistance exercise in rat skeletal muscle
- Proteomic analysis reveals hyperactivation of the mammalian target of Rapamycin pathway in neurofibromatosis 1–associated human and mouse brain tumors
- Rapamycin (sirolimus) for treatment of chronic graft-versus-host disease
- Mutual antagonism of target of Rapamycin and calcineurin signaling
- Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas
- inhibition of corneal neovascularization by Rapamycin
- Calcineurin inhibitors, but not Rapamycin, reduce percentages of CD4+ CD25+ FOXP3+ regulatory T cells in renal transplant recipients
- Androgens induce prostate cancer cell proliferation through mammalian target of Rapamycin activation and post-transcriptional increases in cyclin D proteins
- Dexamethasone represses signaling through the mammalian target of Rapamycin in muscle cells by enhancing expression of REDD1
- In vitro release of the mTOR inhibitor Rapamycin from poly (ethylene glycol)-b-poly (ε-caprolactone) micelles
- Low-dose oral Rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis
- Antitumor activity of Rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer
- Translational control via the mammalian target of Rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons
- Rapamycin induces Smad activity in prostate cancer cell lines
- Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bϵ mRNA in a mammalian target of Rapamycin …
- Differential effect of calcineurin inhibitors, anti-CD25 antibodies and Rapamycin on the induction of FOXP3 in human T cells
- The mammalian target of Rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
- Effects of the mammalian target of Rapamycin inhibitor CCI-779 used alone or with chemotherapy on human prostate cancer cells and xenografts
- Rapamycin inhibits doxorubicin-induced NF-κB/Rel nuclear activity and enhances the apoptosis of melanoma cells
- Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex–mammalian target of Rapamycin pathway
- Rapamycin induces heme oxygenase-1 in human pulmonary vascular cells: implications in the antiproliferative response to Rapamycin
- New targets for therapy in breast cancer: mammalian target of Rapamycin (mTOR) antagonists
- Modulation of the mammalian target of Rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid
- Human cytomegalovirus infection induces Rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase
- Mammalian target of Rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor …
- … predictors of angiographic restenosis after sirolimus-eluting stent implantation in complex patients: an evaluation from the Rapamycin-Eluting Stent Evaluated At …
- Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of Rapamycin
- Ischemia-reperfusion induces glomerular and tubular activation of proinflammatory and antiapoptotic pathways: differential modulation by Rapamycin
- Rpd3p relocation mediates a transcriptional response to Rapamycin in yeast
- Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of Rapamycin pathway in breast cancer cells
- Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of Rapamycin kinase inhibitor, in patients with advanced refractory renal cell …
- Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy
- Activation of the mammalian target of Rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes
- Akt1 Activation Can Augment Hypoxia-Inducible Factor-1α Expression by Increasing Protein Translation through a Mammalian Target of Rapamycin–Independent …
- Rapamycin inhibits GM-CSF-induced neutrophil migration
- The mammalian target of the Rapamycin (mTOR) kinase pathway: its role in tumourigenesis and targeted antitumour therapy
- Delayed graft function and cast nephropathy associated with tacrolimus plus Rapamycin use
- Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the Rapamycin gene cluster
- Recent developments in targeting the mammalian target of Rapamycin (mTOR) kinase pathway
- Domains of Gln3p interacting with karyopherins, Ure2p, and the target of Rapamycin protein
- Rapamycin-eluting stents for the treatment of unprotected left main coronary disease
- Rapamycin induces regression of endometriotic lesions by inhibiting neovascularization and cell proliferation
- Activation of mammalian target of Rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase–positive anaplastic large cell …
- Rapamycin-induced endothelial cell death and tumor vessel thrombosis potentiate cytotoxic therapy against pancreatic cancer
- Activation of mammalian target of Rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1
- Mammalian target of Rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma …
- inhibition of mammalian target of Rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras
- Raptor, a binding partner of target of Rapamycin
- Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring …
- Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)
- Molecular mechanisms through which amino acids mediate signaling through the mammalian target of Rapamycin
- … outcome after drug-eluting stent implantation for the percutaneous treatment of left main coronary artery disease: insights from the Rapamycin-Eluting and Taxus Stent …
- Rapamycin biosynthesis: elucidation of gene product function
- Effect of Rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in Eμ-TCL1 transgenic mice
- Roles of glutamate receptors and the mammalian target of Rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in …
- New Rapamycin derivatives by precursor‐directed biosynthesis
- Thyroid Hormone Induces Rapid Activation of Akt/Protein Kinase B-Mammalian Target of Rapamycin-p70S6K Cascade through Phosphatidylinositol 3-Kinase in …
- Target of Rapamycin-dependent activation of S6 kinase is a central step in the transduction of nutritional signals during egg development in a mosquito
- inhibition of mammalian target of Rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity
- … growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin (PI3K/Akt/mTOR) …
- Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of Rapamycin
- Chronic inhibition of mammalian target of Rapamycin signaling downregulates insulin receptor substrates 1 and 2 and AKT activation: a crossroad between cancer and …
- Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2α kinase GCN2
- Control of dendritic arborization by the phosphoinositide-3′-kinase–Akt–mammalian target of Rapamycin pathway
- Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing’s sarcoma cell proliferation
- Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin
- Mammalian target of Rapamycin as a therapeutic target in leukemia
- Activation of mammalian target of Rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma
- Nutrient-dependent multimerization of the mammalian target of Rapamycin through the N-terminal HEAT repeat region
- Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of Rapamycin
- Mammalian target of Rapamycin (mTOR) inhibitors as anti-cancer agents
- Long-term treatment of bile duct-ligated rats with Rapamycin (sirolimus) significantly attenuates liver fibrosis: analysis of the underlying mechanisms
- Mechanism by which mammalian target of Rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis
- Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of Rapamycin
- Mammalian target of Rapamycin inhibition induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitises DLBCL cells to rituximab
- Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to Rapamycin in an Akt-dependent manner via p38 MAPK signaling
- The Rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation
- Pilot trial of oral Rapamycin for recalcitrant restenosis
- Effect of Rapamycin on renal ischemia‐reperfusion injury in mice
- Rapamycin delays but does not prevent recovery from acute renal failure: role of acquired tubular resistance
- ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of Rapamycin/p70S6K leading to increased angiogenesis and …
- Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression
- Successful conversion to Rapamycin for calcineurin inhibitor-related neurotoxicity following liver transplantation
- Synergistic effect of targeting mTOR by Rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells
- Cyclosporin A and tacrolimus, but not Rapamycin, inhibit MHC-restricted antigen presentation pathways in dendritic cells
- Rapamycin inhibits growth and survival of D816V-mutated c-kit mast cells
- United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of Rapamycin (mTOR) signalling
- Target of Rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding …
- … sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of Rapamycin …
- Rapamycin attenuates atherosclerosis induced by dietary cholesterol in apolipoprotein-deficient mice through a p27Kip1-independent pathway
- Mammalian target of Rapamycin positively regulates collagen type I production via a phosphatidylinositol 3-kinase-independent pathway
- Human cytomegalovirus infection alters the substrate specificities and Rapamycin sensitivities of raptor-and rictor-containing complexes
- Regulation of Leucine Uptake by tor1+ in Schizosaccharomyces pombe Is Sensitive to Rapamycin
- TCR engagement increases hypoxia-inducible factor-1α protein synthesis via Rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells
- Early outcome after sirolimus-eluting stent implantation in patients with acute coronary syndromes: insights from the Rapamycin-Eluting Stent Evaluated At Rotterdam …
- Mammalian target of Rapamycin (mTOR) signaling is required for a late-stage fusion process during skeletal myotube maturation
- Local application of Rapamycin inhibits neointimal hyperplasia in experimental vein grafts
- Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by Rapamycin through a p38 MAPK …
- GATA factor translation is the final downstream step in the amino acid/target-of-Rapamycin-mediated vitellogenin gene expression in the anautogenous …
- Rapamycin attenuates atherosclerotic plaque progression in apolipoprotein E knockout mice: inhibitory effect on monocyte chemotaxis
- Rapamycin attenuates vascular wall inflammation and progenitor cell promoters after angioplasty
- Akt1/Akt2 and mammalian target of Rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell …
- Fibronectin stimulates non–small cell lung carcinoma cell growth through activation of Akt/mammalian target of Rapamycin/S6 kinase and inactivation of LKB1/AMP …
- Activation of the phosphoinositide 3-kinase-Akt-mammalian target of Rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long …
- Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV β-chemokines: an approach to suppress R5 strains of HIV-1
- … in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson’s disease by a mechanism involving mammalian target of Rapamycin …
- Glucagon represses signaling through the mammalian target of Rapamycin in rat liver by activating AMP-activated protein kinase
- Isolation and Characterization of Pre‐Rapamycin, the First Macrocyclic Intermediate in the Biosynthesis of the Immunosuppressant Rapamycin by S. hygroscopicus
- Type D personality predicts death or myocardial infarction after bare metal stent or sirolimus-eluting stent implantation: a Rapamycin-Eluting Stent Evaluated at …
- A high-throughput method for screening of Rapamycin-producing strains of Streptomyces hygroscopicus by cultivation in 96-well microtiter plates
- Phosphatidic acid regulates systemic inflammatory responses by modulating the Akt-mammalian target of Rapamycin-p70 S6 kinase 1 pathway
- Comparative effects of paclitaxel and Rapamycin on smooth muscle migration and survival: role of AKT-dependent signaling
- Production of novel Rapamycin analogs by precursor-directed biosynthesis
- Rapamycin inhibits telomerase activity by decreasing the hTERT mRNA level in endometrial cancer cells1
- Effects of Rapamycin on number activity and eNOS of endothelial progenitor cells from peripheral blood
- Predictive and prognostic role of activated mammalian target of Rapamycin in cervical cancer treated with cisplatin-based neoadjuvant chemotherapy
- Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of Rapamycin (mTOR)-induced negative feedback down-regulates …
- A Rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein β and NF-κB activity in Hodgkin and …
- Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of Rapamycin and for recognition by raptor
- A nuclear transport signal in mammalian target of Rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
- Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of Rapamycin (mTOR)-independent
- … undergoing percutaneous intervention in the drug-eluting stent era: an integrated clinical and angiographic analysis based on the Rapamycin-Eluting Stent Evaluated …
- Antiangiogenic and immunomodulatory effects of Rapamycin on islet endothelium: relevance for islet transplantation
- Rapamycin mimics the incompatibility reaction in the fungus Podospora anserina
- Rapamycin effects transcriptional programs in smooth muscle cells controlling proliferative and inflammatory properties
- An open prospective pilot study on the use of Rapamycin after penetrating high-risk keratoplasty
- Ex vivo Rapamycin generates Th1/Tc1 or Th2/Tc2 Effector T cells with enhanced in vivo function and differential sensitivity to post-transplant Rapamycin therapy
- Post-transcriptional regulation of the androgen receptor by Mammalian target of Rapamycin
- Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax: Bcl-xL ratio through concurrent mechanisms dependent and independent of its …
- Efficacy of Rapamycin in patient with juvenile rheumatoid arthritis
- Mammalian target of Rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation
- Effects of Rapamycin on accumulation of α‐, β‐ and γ‐globin mRNAs in erythroid precursor cells from β‐thalassaemia patients
- Rapamycin and chronic kidney disease: beyond the inhibition of inflammation
- Overexpressed eIF4E is functionally active in surgical margins of head and neck cancer patients via activation of the Akt/mammalian target of Rapamycin pathway
- inhibition of the mammalian target of Rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells
- LY294002 and Rapamycin co‐operate to inhibit T‐cell proliferation
- The mTOR inhibitor Rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells
- The immunosuppressant Rapamycin exacerbates neurotoxicity of Aβ peptide
- … transcriptionally and posttranslationally through phosphatidylinositol 3′-kinase/Akt, heat shock protein 90, and mammalian target of Rapamycin in transformed NK …
- From Rapa Nui to Rapamycin: targeting PI3K/Akt/mTOR for cancer therapy
- Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of Rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways …
- Statins induce mammalian target of Rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs
- Target of Rapamycin inhibitors (TOR‐I; sirolimus and everolimus) for primary immunosuppression in kidney transplant recipients
- Phophatidylinositol-3 Kinase/Mammalian Target of Rapamycin/p70S6K Regulates Contractile Protein Accumulation in Airway Myocyte Differentiation
- Amino acid signaling through the mammalian target of Rapamycin (mTOR) pathway: role of glutamine and of cell shrinkage
- Rapamycin: friend, foe, or misunderstood?
- Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ
- The product of the UTH1 gene, required for Bax‐induced cell death in yeast, is involved in the response to Rapamycin
- Effects of FK506 and Rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes
- Sustained intraocular Rapamycin delivery effectively prevents high-risk corneal allograft rejection and neovascularization in rabbits
- Effects of Rapamycin on the epithelial-to-mesenchymal transition of human peritoneal mesothelial cells
- Mammalian target of Rapamycin
- Rapamycin analogs for stent-based local drug delivery
- Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of Rapamycin pathway
- Differential effects of immunosuppressive drugs on chemokine receptor CCR7 in human monocyte-derived dendritic cells: selective upregulation by Rapamycin
- Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of Rapamycin activity and increased translation under hypoxic conditions
- Rapamycin disrupts cyclin/cyclin-dependent kinase/p21/proliferating cell nuclear antigen complexes and cyclin D1 reverses Rapamycin action by stabilizing these …
- Mechanisms of action of Rapamycin in gliomas
- Enhancement of translation elongation in neurons by brain‐derived neurotrophic factor: Implications for mammalian target of Rapamycin signaling
- Oral Rapamycin to inhibit restenosis after stenting of de novo coronary lesions: the Oral Rapamune to Inhibit Restenosis (ORBIT) study
- Effects of combined treatment with Rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts
- Group I metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of Rapamycin (mTOR) and extracellular signal-regulated kinase (ERK …
- Rapamycin and tumor growth: mechanisms behind its anticancer activity
- inhibition of mammalian target of Rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-κB …
- Insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of Rapamycin signaling pathway
- Modulation of insulin action by dietary proteins and amino acids: role of the mammalian target of Rapamycin nutrient sensing pathway
- Rituximab in association with Rapamycin for post-transplant lymphoproliferative disease treatment
- … macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a Rapamycin-sensitive, mTOR-related …
- Rapamycin‐mediated induction of γ‐globin mRNA accumulation in human erythroid cells
- Differing responses of Gat1 and Gln3 phosphorylation and localization to Rapamycin and methionine sulfoximine treatment in Saccharomyces cerevisiae
- Mammalian target of Rapamycin inhibitors in combination with letrozole in breast cancer
- … 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of Rapamycin signaling pathway and …
- Rapamycin does not induce anergy but inhibits expansion and differentiation of alloreactive human T cells
- Combination therapy of mycophenolate mofetil and Rapamycin in prevention of chronic renal allograft rejection in the rat1
- Rapamycin worsens renal function and intratubular cast formation in protein overload nephropathy
- Synergistic inhibition of human neuroblastoma-related angiogenesis by vinblastine and Rapamycin
- Rapamycin inhibits human renal epithelial cell proliferation: effect on cyclin D3 mRNA expression and stability
- … identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and Rapamycin
- Gln3 phosphorylation and intracellular localization in nutrient limitation and starvation differ from those generated by Rapamycin inhibition of Tor1/2 in …
- Rapamycin preserves renal function compared with cyclosporine A after ischemia/reperfusion injury
- … -inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of Rapamycin (mTOR) pathway is …
- Superior T-cell suppression by Rapamycin and FK506 over Rapamycin and cyclosporine A because of abrogated cytotoxic T-lymphocyte induction, impaired memory …
- Estrogen-induced activation of mammalian target of Rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain
- … progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin pathway: progesterone receptor as …
- Acceleration of apoptosis in CD4+ CD8+ thymocytes by Rapamycin accompanied by increased CD4+ CD25+ T cells in the periphery1
- Intracellular network of phosphatidylinositol 3‐kinase, mammalian target of the Rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen‐activated protein kinases …
- Interleukin-12-induced interferon-γ production by human peripheral blood T cells is regulated by mammalian target of Rapamycin (mTOR)
- Pilot study of oral Rapamycin to prevent restenosis in patients undergoing coronary stent therapy: Argentina Single-Center Study (ORAR Trial)
- … artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of Rapamycin/p70 ribosomal S6 kinase …
- Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of Rapamycin signaling pathway
- ROS fusion tyrosine kinase activates a SH2 domain–containing phosphatase-2/phosphatidylinositol 3-Kinase/mammalian target of Rapamycin signaling axis to form …
- Hyperactivation of mammalian target of Rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase
- Oral Rapamycin inhibits growth of atherosclerotic plaque in apoE knock-out mice
- Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs
- inhibition of insulin signaling and adipogenesis by Rapamycin: effect on phosphorylation of p70 S6 kinase vs eIF4E-BP1
- Stable expression of small interfering RNA sensitizes TEL-PDGFβR to inhibition with imatinib or Rapamycin
- Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of Rapamycin
- Insulin-like growth factor I-mediated protection from Rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3′-kinase-Akt signaling …
- Efficacy of polyphenon E, red ginseng, and Rapamycin on benzo (a) pyrene-induced lung tumorigenesis in A/J mice
- … of mTOR as a novel bifunctional target in chronic myeloid leukemia: dissection of growth‐inhibitory and VEGF‐suppressive effects of Rapamycin in leukemic cells
- Sustained activation of the mammalian target of Rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in …
- Rapamycin antagonizes NF-κB nuclear translocation activated by TNF-α in primary vascular smooth muscle cells and enhances apoptosis
- Rapamycin inhibits fibronectin-induced migration of the human arterial smooth muscle line (E47) through the mammalian target of Rapamycin
- Rapamycin (sirolimus) as a steroid-sparing agent in dermatomyositis
- Mammalian target of Rapamycin (mTOR) inhibitors
- Glucose-stimulated DNA synthesis through mammalian target of Rapamycin (mTOR) is regulated by KATP channels: effects on cell cycle progression in rodent …
- Targeting the AIB1 oncogene through mammalian target of Rapamycin inhibition in the mammary gland
- Activation of mammalian target of Rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular …
- Sirolimus-eluting stents remain superior to bare-metal stents at two years: medium-term results from the Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology …
- Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a Rapamycin-and farnesylation-dependent manner
- Rapamycin analogs with reduced systemic exposure
- Mammalian target of Rapamycin and protein kinase A signaling mediate the cardiac transcriptional response to glutamine
- Rapamycin decreases leukocyte migration in vivo and effectively reduces experimentally induced chronic colitis
- Exercise‐induced alterations in extracellular signal‐regulated kinase 1/2 and mammalian target of Rapamycin (mTOR) signalling to regulatory mechanisms of mRNA …
- Mechanistic insights into impaired dendritic cell function by Rapamycin: inhibition of Jak2/Stat4 signaling pathway
- Cyclin D3 is down-regulated by Rapamycin in HER-2-overexpressing breast cancer cells
- Rapamycin in children after liver transplantation
- inhibition of the phosphatidylinositol 3-kinase/mammalian target of Rapamycin pathway in hematologic malignancies
- Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal …
- Activation of mammalian target of Rapamycin in postmenopausal ovarian endometriosis
- Fatal infection after Rapamycin eluting coronary stent implantation
- Effect of Rapamycin on the healing of the bile duct
- Rapamycin in lung transplantation
- Evidence for cyclin D3 as a novel target of Rapamycin in human T lymphocytes
- Rapamycin in combination with cyclosporine or tacrolimus in liver, pancreas, and kidney transplantation
- Lipase-catalyzed regioselective esterification of Rapamycin: synthesis of temsirolimus (CCI-779)
- Role of oral Rapamycin to prevent restenosis in patients with de novo lesions undergoing coronary stenting: results of the Argentina single centre study (ORAR trial)
- Structure-based design of AP23573, a phosphorus-containing analog of Rapamycin for anti-tumor therapy.
- Rapamycin inhibits proliferation of human neuroblastoma cells without suppression of MycN
- Rapamycin inhibits hTERT telomerase mRNA expression, independent of cell cycle arrest
- … of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of Rapamycin (RAD001) offers improved …
- Ex vivo Rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanism
- Studies investigating pretransplant donor-specific blood transfusion, Rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin …
- Early renal benefit of Rapamycin combined with reduced calcineurin inhibitor dose in pediatric heart transplantation patients
- inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung …
- … Receptor Substrate-1 on Ser307 and Ser612 and Impairs the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Insulin Biosynthetic Pathway in …
- Insulin facilitation of muscle protein synthesis following resistance exercise in hindlimb-suspended rats is independent of a Rapamycin-sensitive pathway
- The role of heme oxygenase 1 in Rapamycin-induced renal dysfunction after ischemia and reperfusion injury
- Rapamycin inhibits human in stent restenosis vascular smooth muscle cells independently of pRB phosphorylation and p53
- Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma
- Perturbed IFN-γ-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of Rapamycin-IFN-γ treatment
- Roles of phosphatidylinositol 3′-kinase and mammalian target of Rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial …
- EFFECT OF Rapamycin ON THE FATE OF P23H OPSIN ASSOCIATED WITH RETINITS PIGMENTOSA (AN AMERICAN OPHTHALMOLOGICAL SOCIETY …
- Synergistic immunosuppressive effects of rosmarinic acid and Rapamycin in vitro and in vivo1
- Long-term islet allograft survival in nonobese diabetic mice treated with tacrolimus, Rapamycin, and anti-interleukin-2 antibody1
- Signaling interactions of Rapamycin combined with erlotinib in cervical carcinoma xenografts
- Rapamycin inhibits release of tumor necrosis factor-[alpha] from human vascular smooth muscle cells
- CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of Rapamycin pathway
- Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of Rapamycin/p70 S6K pathway
- Mammalian target of Rapamycin is required for thrombopoietin‐induced proliferation of megakaryocyte progenitors
- The fission yeast TOR proteins and the Rapamycin response: an unexpected tale
- Safety and pharmacokinetics of ascending single doses of sirolimus (Rapamune®, Rapamycin) in pediatric patients with stable chronic renal failure undergoing …
- Use of Rapamycin-impregnated stents in coronary arteries
- In Vivo and In Vitro Effects of SAR 943, a Rapamycin Analogue, on Airway Inflammation and Remodeling
- Farnesylthiosalicylic Acid Inhibits Mammalian Target of Rapamycin (mTOR) Activity Both in Cells and in Vitro by Promoting Dissociation of the mTOR-Raptor Complex
- Regulation of microtubule-dependent protein transport by the TSC2/mammalian target of Rapamycin pathway
- Pharmacokinetics of sirolimus (Rapamycin) in subjects with mild to moderate hepatic impairment
- Low-dose radiation plus Rapamycin promotes long-term bone marrow chimerism
- Rapamycin-coated expanded polytetrafluoroethylene bypass grafts exhibit decreased anastomotic neointimal hyperplasia in a porcine model
- Anti–third-party veto CTLs overcome rejection of hematopoietic allografts: synergism with Rapamycin and BM cell dose
- Combination of imatinib with Rapamycin or RAD001 acts synergistically only in Bcr-Abl-positive cells with moderate resistance to imatinib
- Outcomes of using Firebird Rapamycin eluting stents in routine coronary intervention practice: one-year results from the pilot study of Firebird in China registry
- Prolactin activates mammalian target-of-Rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 …
- Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug Rapamycin: A direct role as an antifibrotic agent?
- Pmr1, a Golgi Ca2+/Mn2+-ATPase, is a regulator of the target of Rapamycin (TOR) signaling pathway in yeast
- Rapamycin ameliorates experimental autoimmune myocarditis
- First experience with Rapamycin-based immunosuppression to improve kidney function after heart transplantation
- Three-year clinical follow-up of the unrestricted use of sirolimus-eluting stents as part of the Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology Hospital …
- The mammalian target of Rapamycin-p70 ribosomal S6 kinase but not phosphatidylinositol 3-kinase-Akt signaling is responsible for fibroblast growth factor-9 …
- Differential effects of Rapamycin, cyclosporine A, and FK506 on human coronary artery smooth muscle cell proliferation and signalling
- Rapamycin causes activation of protein phosphatase-2A1 and nuclear translocation of PCNA in CD4+ T cells
- Rapamycin: a new string to the antiproteinuric bow?
- … the treatment of distal left main coronary artery disease in the drug-eluting stenting era. Clinical and angiographic insights into the Rapamycin-Eluting Stent Evaluated …
- Mammalian target of Rapamycin inhibitors in sarcomas
- Liposomal formulations of tacrolimus and Rapamycin increase graft survival and fiber outgrowth of dopaminergic grafts
- Rapamycin treatment is associated with an increased apoptosis rate in experimental vein grafts
- 5‐HT stimulates eEF2 dephosphorylation in a Rapamycin‐sensitive manner in Aplysia neurites
- Blockage of 2-deoxy-D-ribose-induced angiogenesis with Rapamycin counteracts a thymidine phosphorylase-based escape mechanism available for colon cancer …
- Rapamycin in lung transplantation: preliminary results
- Tsc1 haploinsufficiency without mammalian target of Rapamycin activation is sufficient for renal cyst formation in Tsc1+/− mice
- Novel sulfur-containing Rapamycin analogs prepared by precursor-directed biosynthesis
- Rapamycin inhibits Akt-mediated oncogenic transformation and tumor growth
- Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin
- Akt and mammalian target of Rapamycin regulate separate systems of proteolysis in renal tubular cells
- … with targeted therapies against epidermal growth factor receptor/human epidermal growth factor receptor 2 and mammalian target of Rapamycin in breast cancer
- Mammalian target of Rapamycin regulates the growth of mammary epithelial cells through the inhibitor of deoxyribonucleic acid binding Id1 and their functional …
- The effect of Rapamycin on the healing of the ureteric anastomosis and wound healing
- Effect of SU11248 on gastrointestinal stromal tumor‐T1 cells: Enhancement of growth inhibition via inhibition of 3‐kinase/Akt/mammalian target of Rapamycin signaling
- Combination of a Rapamycin analog (CCI‐779) and interferon‐γ is more effective than single agents in treating a mouse model of tuberous sclerosis complex
- Overcoming T cell–mediated rejection of bone marrow allografts by T-regulatory cells: Synergism with veto cells and Rapamycin
- Routine sirolimus eluting stent implantation for unselected in-stent restenosis: insights from the Rapamycin eluting stent evaluated at Rotterdam Cardiology Hospital …
- Rapamycin inhibits liver growth during refeeding in rats via control of ribosomal protein translation but not cap-dependent translation initiation
- … is regulated by phosphorylation and turnover of protein kinase C βII mediated by phosphatidylinositol 3-kinase-and mammalian target of Rapamycin …
- Rapamycin rescue therapy in patients after kidney transplantation: first clinical experience
- Heme oxygenase-1 mediates the protective effects of Rapamycin in monocrotaline-induced pulmonary hypertension
- Successful treatment of a severe case of idiopathic pulmonary fibrosis with Rapamycin
- Evaluation of Rapamycin chemical stability in volatile-organic solvents by HPLC
- Characterization of the cloned full-length and a truncated human target of Rapamycin: activity, specificity, and enzyme inhibition as studied by a high capacity assay
- Rapamycin reduces neointima formation during vascular injury.
- Effects of aerobic exercise training on the protein kinase B (PKB)/mammalian target of Rapamycin (mTOR) signaling pathway in aged skeletal muscle
- Effects of Rapamycin on the arterial inflammatory response in atherosclerotic plaques in Apo-E knockout mice
- Effects of cyclosporin A and a Rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats
- Rapamycin induces a caspase‐independent cell death in human monocytes
- Acute renal failure following kidney transplantation associated with myoglobinuria in patients treated with Rapamycin
- Rapamycin inhibits cdk4 activation, p 21WAF1/CIP1 expression and G1‐phase progression in transformed mouse fibroblasts
- Oral Rapamycin to prevent human coronary stent restenosis: a pilot study
- A downstream kinase of the mammalian target of Rapamycin, p70S6K1, regulates human double minute 2 protein phosphorylation and stability
- Rapamycin-resistant proliferation of CD8+ T cells correlates with p27kip1 down-regulation and bcl-xL induction, and is prevented by an inhibitor of …
- In rat hepatocytes glucagon increases mammalian target of Rapamycin phosphorylation on serine 2448 but antagonizes the phosphorylation of its downstream …
- Podospora anserina target of Rapamycin
- Mammalian target of Rapamycin and 3-phosphatidylinositol 3-kinase pathway inhibition enhances growth inhibition of transforming growth factor-β1 in prostate cancer …
- Actin cytoskeleton is required for nuclear accumulation of Gln3 in response to nitrogen limitation but not Rapamycin treatment in Saccharomyces cerevisiae
- Post-Rapamycin proteinuria: incidence, evolution, and therapeutic handling at a single center
- Farnesylthiosalicylic acid blocks mammalian target of Rapamycin signaling in breast cancer cells
- Prevention of lethal acute GVHD with an agonistic CD28 antibody and Rapamycin
- Effects of simian virus 40 large and small tumor antigens on mammalian target of Rapamycin signaling: small tumor antigen mediates hypophosphorylation of eIF4E …
- Rapamycin‐sensitive induction of eukaryotic initiation factor 4F in regenerating mouse liver
- Nutrient restriction differentially modulates the mammalian target of Rapamycin signaling and the ubiquitin-proteasome system in skeletal muscle of cows and their …
- The Saccharomyces cerevisiae phosphatase activator RRD1 is required to modulate gene expression in response to Rapamycin exposure
- Aortic eNOS expression and phosphorylation in Apo-E knockout mice: differing effects of Rapamycin and simvastatin
- Mammalian target of Rapamycin (mTOR) inhibition in chronic lymphocytic B-cell leukemia: a new therapeutic option
- … and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-γ is regulated by mammalian target of Rapamycin
- The influence of the Rapamycin-derivate SDZ RAD on the healing of airway anastomoses
- Cilomilast, tacrolimus and Rapamycin modulate dendritic cell function in the elicitation phase of allergic contact dermatitis
- The impact of cyclosporine dose reduction with or without the addition of Rapamycin on functional, molecular, and histological markers of chronic allograft nephropathy
- Role of endothelin-1 and nitric oxide bioavailability in transplant-related vascular injury: comparative effects of Rapamycin and cyclosporine
- Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of Rapamycin-dependent …
- Mammalian target of Rapamycin is a promising target for novel therapeutic strategy against cancer.
- Effects of cyclosporin A, FK506 and Rapamycin on calcineurin phosphatase activity in mouse brain
- Both mitogen activated protein kinase and the mammalian target of Rapamycin modulate the development of functional renal proximal tubules in matrigel
- Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of Rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast …
- Effects of Rapamycin on cardiac and skeletal muscle contraction and crossbridge cycling
- Frap, FKBP12 Rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene
- Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both Rapamycin-sensitive and-insensitive …
- Modulation of translation‐initiation in CHO‐K1 cells by Rapamycin‐induced heterodimerization of engineered eIF4G fusion proteins
- Rapamycin antagonizes cyclosporin A‐and tacrolimus (FK506)‐mediated augmentation of linker for activation of T cell expression in T cells
- Activation of mammalian target of Rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL–expressing cells
- Proteomic analysis of anti‐angiogenic effects by a combined treatment with vinblastine and Rapamycin in an endothelial cell line
- The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of Rapamycin in the response of normal fibroblasts to ionizing radiation
- Sirolimus (Rapamycin) monotherapy prevents graft vascular disease in nonhuman primate recipients of orthotopic aortic allografts
- Mammalian target of Rapamycin inhibitors in renal cell carcinoma: current status and future applications
- Investigating mammalian target of Rapamycin inhibitors for their anticancer properties
- Rapamycin treatment results in GATA factor-independent hyperphosphorylation of the proline utilization pathway activator in Saccharomyces cerevisiae
- The Rapamycin derivative RAD inhibits mesangial cell migration through the CDK-inhibitor p27 Kip1
- Combination therapy for treating breast cancer using antiestrogen, ERA-923, and the mammalian target of Rapamycin inhibitor, temsirolimus
- Generating Rapamycin analogues by directed biosynthesis: starter acid substrate specificity of mono-substituted cyclohexane carboxylic acids
- Electron microscopic and biochemical study of the effects of Rapamycin on glycogen autophagy in the newborn rat liver
- … 4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of Rapamycin (mTOR)-and non …
- Rapamycin in patients with chronic renal allograft dysfunction
- Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of Rapamycin, and ribosomal S6 kinase 1 signaling pathways …
- … of metallothionein rescues chronic alcohol intake-induced cardiomyocyte dysfunction: role of Akt, mammalian target of Rapamycin and ribosomal p70s6 kinase
- Rapamycin inhibits E2F-dependent expression of minichromosome maintenance proteins in vascular smooth muscle cells
- Targeting metastatic leiomyosarcoma by Rapamycin plus gemcitabine: an intriguing clinical observation
- Vanadate and Rapamycin synergistically enhance insulin-stimulated glucose uptake
- Rapamycin control of transgene expression from a single AAV vector in mouse salivary glands
- Cutaneous leukocytoclastic vasculitis in a patient with myelodysplatic syndrome after therapy with the Rapamycin analogue everlimus: Case report and review of the …
- Determining sensitivity to Rapamycin and its analogues in breast cancer patients
- Rapamycin pre‐treatment preserves viability, ATP level and catabolic capacity during carbon starvation of Saccharomyces cerevisiae
- Rapamycin and FK506 reduce skeletal muscle voltage sensor expression and function
- Extracellular ATP-induced proliferation of adventitial fibroblasts requires phosphoinositide 3-kinase, Akt, mammalian target of Rapamycin, and p70 S6 kinase …
- The mTOR pathway in estrogen response: A potential for combining the Rapamycin derivative RAD001 with the aromatase inhibitor Letrozole (Femara®) in breast …
- inhibition of mammalian target of Rapamycin modulates expression of adhesion molecules in endothelial cells
- SUMO modification through Rapamycin-mediated heterodimerization reveals a dual role for Ubc9 in targeting RanGAP1 to nuclear pore complexes
- Cyclosporine and Rapamycin act in a synergistic and dose-dependent manner in a model of immunosuppressant-induced kidney damage
- Current Data with Mammalian Target of Rapamycin Inhibitors in Advanced Renal Cell Carcinoma
- Novel site‐specific systemic delivery of Rapamycin with perfluorobutane gas microbubble carrier reduced neointimal formation in a porcine coronary restenosis model
- The phosphatase subunit tap42 functions independently of target of Rapamycin to regulate cell division and survival in Drosophila
- Rapamycin control of exocrine protein levels in saliva after adenoviral vector-mediated gene transfer
- Farnesyltransferase inhibitors and Rapamycin in the treatment of multiple myeloma
- RACK1 mRNA translation is regulated via a Rapamycin-sensitive pathway and coordinated with ribosomal protein synthesis
- Mammalian target of Rapamycin promotes vincristine resistance through multiple mechanisms independent of maintained glycolytic rate
- Bone morphogenetic protein-2–induced transformation involves the activation of mammalian target of Rapamycin
- Rapamycin prolongs susceptibility of responding T cells to tolerance induction by CD8+ veto cells
- Current status of mammalian target of Rapamycin inhibitors in lung cancer
- Rapamycin inhibits vascular remodeling in an experimental model of allograft vasculopathy and attenuates associated changes in fibrosis-associated gene …
- Rapamycin and dendritic cells: keep on movin’
- Involvement of c-Jun NH2 terminal kinase and p38MAPK in Rapamycin-mediated inhibition of neointimal formation in rat carotid arteries
- Involvement of the VDE homing endonuclease and Rapamycin in regulation of the Saccharomyces cerevisiae GSH11 gene encoding the high affinity …
- Immunomodulatory effects of combination of pooled human gammaglobulin and Rapamycin on cell proliferation and apoptosis in the mixed lymphocyte reaction
- Six-month intravascular ultrasound follow-up of coronary bifurcation lesions treated with Rapamycin-eluting stents: technical considerations
- Trace analysis of Rapamycin in human blood by micellar electrokinetic chromatography
- Insulin-like growth factor binding protein-6 and CCI-779, an ester analogue of Rapamycin, additively inhibit rhabdomyosarcoma growth
- Differential translation of TOP mRNAs in Rapamycin-treated human B lymphocytes
- Rapamycin for androgen-independent prostrate cancer (AIPC)
- Rapamycin for cardiac transplant rejection and vasculopathy: one stone, two birds?
- Sirolimus and everolimus: inhibitors of mammalian target of Rapamycin in liver transplantation
- Rapamycin inhibits choroidal neovascularization
- Deletion of HOG1 leads to Osmosensitivity in starvation-induced, but not Rapamycin-dependent Atg8 degradation and proteolysis: Further evidence for different …
- Structure and function of mammalian target of Rapamycin [J]
- Comparison of Rapamycin and paclitaxel eluting stent in patients with multi-vessel coronary disease
- Retracted: Rapamycin Attenuates Liver Graft Injury in Cirrhotic Recipient—The Significance of Down‐Regulation of Rho‐ROCK‐VEGF Pathway
- Pharmacokinetics of Rapamycin-eluting stents in miniswine coronary model.
- Combination therapy with sirolimus (Rapamycin) and tacrolimus (FK-506) in treatment of refractory minimal change nephropathy, a clinical case report
- Combination of the mammalian target of Rapamycin (mTOR) inhibitor everolimus (E) with the insulin like growth factor-1-receptor (IGF-1-R) inhibitor NVP-AEW-541: A …
- Rapamycin and chronic lung rejection
- Synergistic suppression of rat neointimal hyperplasia by Rapamycin and imatinib mesylate: implications for the prevention of accelerated arteriosclerosis
- An intramolecular ionic hydrogen bond stabilizes a cis amide bond rotamer of a ring‐opened Rapamycin‐degradation product
- The effect of combined Rapamycin/cyclosporine on the changes in pro-fibrotic gene expression that occur during the development of allograft vasculopathy in rats …
- Modulation of tissue factor expression by Rapamycin and FK-506 in lipopolysaccharide-stimulated human mononuclear cells and serum-stimulated aortic smooth …
- Effect of Rapamycin on hepatic osteodystrophy in rats with portasystemic shunting
- Preclinical rationale for therapeutic targeting of mTOR by CC-I779 and Rapamycin in Hodgkin lymphoma
- Potential role of mammalian target of Rapamycin inhibitors in breast cancer therapy
- Altered centrosomes in ataxia‐telangiectasia cells and Rapamycin‐treated Chinese hamster cells
- Determination of Rapamycin: quantification of the sodiated species by an ion trap mass spectrometer as an alternative to the ammoniated complex analysis by triple …
- Nutritional studies on the growth of the Rapamycin-producing Streptomyces hygroscopicus
- A novel technique for on‐capillary preconcentration of anionic compounds applied to the trace analysis of Rapamycin in human blood by capillary electrophoresis
- … of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib in combination with the mammalian target of Rapamycin (mTOR) inhibitor everolimus …
- Glucose-induced binding of the polypyrimidine tract-binding protein (PTB) to the 3′-untranslated region of the insulin mRNA (ins-PRS) is inhibited by Rapamycin
- A phase I trial of gefitinib (ZD1839) plus Rapamycin for patients with recurrent malignant glioma
- Clinical use of Rapamycin in renal allograft recipients identifies its relevant toxicity profile and raises unsolved questions: a single-center experience
- Lung toxicity induced by Rapamycin
- Countervailing effects of Rapamycin (sirolimus) on nuclear factor-κB activities in neointimal and medial smooth muscle cells
- Dose-dependent inhibition of myointimal hyperplasia by orally administered Rapamycin
- Association of Rapamycin and co-stimulation blockade using anti-B7 antibodies in renal allotransplantation in baboons
- inhibition of growth and metastasis of hepatocellular carcinoma by Rapamycin: experiment with mice
- Cyclosporine A, FK-506, 40-0-[2-hydroxyethyl] Rapamycin and mycophenolate mofetil inhibit proliferation of human intrahepatic biliary epithelial cells in vitro
- Rapamycin inhibits platelet-derived growth factor-induced collagen, but not fibronectin, synthesis in rat mesangial cells
- A combination of anergic cells’ adoptive transfer and Rapamycin therapy prolongs cardiac allograft survival in mice
- Local application of Rapamycin inhibiting restenosis in experimental vein graft
- Negative regulation of interleukin-12 production by a Rapamycin-sensitive signaling pathway: a brief communication
- Rapamycin-based rescue therapy after chronic rejection in a pediatric liver transplant patient
- Altered trafficking of CD8+ memory T cells after implantation of Rapamycin-eluting stents in patients with coronary artery disease
- Rapamycin at six years can exhibit normal renal function without proteinuria or neoplasia after renal transplantation. A single-center experience
- Expression of placental mammalian target of Rapamycin (mTOR) is altered in relation to fetal growth and mTOR regulates leucine transport
- Regulation of hepatic insulin-like growth factor-binding protein-1 gene expression by insulin: central role for mammalian target of Rapamycin independent of forkhead …
- Rapamycin–a Potential Mechanistically Targeted Therapeutic for Juvenile Myelomonocytic Leukemia.
- In vivo and in vitro effect of CCI-779 a Rapamycin analogue on HNSCC.
- Pathologic assessment of cardiomyocytes in heart transplant recipients treated with Rapamycin or cyclosporine
- Pharmacodynamic-guided, modified continuous reassessment method (mCRM)-based, dose finding study of Rapamycin in adult patients with solid tumors
- Pharmacokinetics and safety of ABT-578, a sirolimus (Rapamycin) analogue, after single intravenous bolus injection in healthy male volunteers
- Rapamycin Inhibits Retinal and Choroidal Neovascularization in Mice
- In Vitro and In Vivo Antileukemic Effects of the mTOR-Targeting Drug Rapamycin in Patients with Imatinib-Resistant CML.
- Dual effects of Rapamycin on immuno-suppression and tumor inhibition
- Rapamycin inhibits the pathogenesis of posterior capsule opacification: experimental study on rabbit [J]
- Sphingosine-1-phosphate–induced smooth muscle cell migration involves the mammalian target of Rapamycin
- Phase I study of gefitinib and Rapamycin in patients with recurrent or progressive glioblastoma (Gbm)
- Rapamycin has no effect on fibrosis-associated gene expression or extracellular matrix accumulation when administered to animals with established or early …
- Effect of Rapamycin on cytokine profile in kidney transplant recipients treated with triple drug therapy
- Rapamycin as rescue therapy in a patient supported by biventricular assist device to heart transplantation with consecutive ongoing rejection
- Effect of Rapamycin on Phenotype of Vascular Smooth Muscle Cell and Arterial Intimal Hyperplasia Post Balloon Injury in Rat [J]
- Rapamycin plays a new role as differentiator of vascular smooth muscle phenotype. Focus on “The mTOR/p70 S6K1 pathway regulates vascular smooth muscle …
- … -up of the unrestricted use of the sirolimus-eluting stent compared to the use of a standard bare metal stent as part of the Rapamycin-Eluting-Stent Evaluated at …
- Observations on quadruple immunosuppression maintenance therapy using Rapamycin, low-dose cyclosporine, mycophenolate mofetil, and prednisone following …
- Mode of action of FK506 and Rapamycin
- Phase I study of Rapamycin (R) in combination with CYP3A4 modifier, ketoconazole (K), in patients with advanced malignancies
- Renal calcium handling after Rapamycin conversion in chronic allograft dysfunction
- Studies towards the synthesis of Rapamycin: Regiocontrol in the addition of carbanions to enantiomerically pure epoxides and the formation of a highly substituted …
- Rapamycin.
- Thrombosis caused by active Rapamycin stents
- Effect of Rapamycin and dexamethasone on differentiation and maturation of murine bone marrow-derived dendritic cells
- Comparison of Rapamycin versus FK506 on expression of cytoprotective genes in the rat kidney allografts undergoing chronic allograft nephropathy
- Why inhibitors of mammalian target of Rapamycin will be important in organ transplantation
- Stent release of a Rapamycin analogue: tissue pharmacokinetics of rapid versus delayed release
- Rapamycin: from the laboratory to the treatment of patients’ arteries
- Experimental study on the effects of Rapamycin in prevention of rat corneal allograft rejection
- Rapamycin overcomes multidrug resistance (MDR) mediated by P-glycoprotein (Pgp), Multidrug Resistance Protein-1 (MRP-1), Breast Cancer Resistance Protein …
- Complete assignments of the 1H and 13C resonances of 40‐epi‐(N1‐tetrazolyl)‐Rapamycin and revised 13C assignments for Rapamycin
- The Combination of the mTOR Inhibitor Rapamycin and Proteasome Inhibitor Bortezomib Is Synergistic In Vitro in Multiple Myeloma.
- Oral Rapamycin for the prevention of in-stent restenosis
- Rapamycin Enhances the Cytotoxicity of Bortezomib and Rituximab on Mantle Cell Lymphoma (MCL) Cell Lines.
- Surviving Rapamycin
- Lack of effect of Rapamycin in anti-CCP antibody production in a rheumatoid arthritis kidney allograft recipient
- Mammalian target of Rapamycin inhibitors in transplantation: novel immunosuppressive strategies with sirolimus
- Efficacy of Early Use of Rapamycin for Patients after Renal Transplantation and the Complications
- 1139-52 Biolimus A9: a new generation Rapamycin analogue inhibits intimal hyperplasia in a porcine model
- Rapamycin eluting stents
- Mammalian target of Rapamycin (mTOR) as a target in human breast cancer cells that have acquired resistance to aromatase inhibitor letrozole
- Rapamycin: sc-3504
- Investigation of Rapamycin and Rapamycin metabolites.
- Inhibitors of mammalian target of Rapamycin: mechanism of action explains efficacy and toxicity
- Rapamycin even when combined with cyclosporine attenuates tumor growth but does not induce regression of established walker sarcomas
- Sirolimus (Rapamycin) reduces the incidence of acute rejection episodes in renal transplantation: An initial experience in Taiwan
- Clinic application of Rapamycin-eluting stent for coronary heart disease [J]
- Intravitreal toxicity of Rapamycin
- Two-year experience with Rapamycin in kidney transplantation
- Safety and efficacy of sirolimus-eluting stent (cypher) in acute myocardial infarction: A substudy of the Rapamycin-Eluting Stent Evaluation at Rotterdam Cardiology …
- Sirolimus-eluting stents for treatment of in-stent restenosis in the real world: Preliminary results from the Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology …
- Rapamycin Combined with Cyclosporine in the Prevention of Acute Renal Allograft Rejection: Randomized Prospective Control Study
- Adverse effects of local or systemic application of Rapamycin for the prevention of neointimal hyperplasia
- Effect of combined regimen of Rapamycin and Cyclosporine on renal transplant recipients [J]
- Short-term Rapamycin for inhibition of neointima formation after balloon-mediated aortic injury in rats: is there a window of opportunity for systemic prophylaxis of …
- Pilot study with oral Rapamycin in patients undergoing stenting in coronary arteries: Buenos Aires experience (ORAR trial)
- CONTRASTING EFFECTS OF CYCLOSPORIN AND Rapamycin IN DE NOVO GENERATION OF ALLOANTIGEN-STIMULATED REGULATORY T CELLS.
- Combination of the mTOR inhibitor Rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17AAG) inhibits proliferation and induces apoptosis …
- Effects of Rapamycin-treated HSP60-pulsed dendritic cells on the progression of the atherosclerotic plaque in mice [J]
- Curcumin disrupts the complexes of the mammalian target of Rapamycin
- Review on Rapamycin as a potential therapeutic agent against neurodegenerative disease
- TOR (target of Rapamycin)-mediated regulation of translation
- Comparison of Different Therapies Of CYPHERTM Stent For Patients with Bifurcated Lesion Using Rapamycin
- Experimental study of effect of Rapamycin on proliferation of rat aortic smooth muscle cells
- Influence of CTLA4Ig combined with Rapamycin on the survival of renal allografts in rats [J]
- Local applied slow-releasing Rapamycin inhibits neointima hyperplasia in vein graft
- Rapamycin PREVENTS INTERSTITIAL FIBROSIS IN RENAL ALLOGRAFTS THROUGH DECREASING ANGIOGENESIS AND INFLAMMATION.
- … Regulatory (CD4+ CD25+ CD127LowFOXP3+) Cells to High Purity by Inhibiting Expansion of CD4+ CD25+ CD127HighFOXP3-Conventional T Cells with Rapamycin …
- Rapamycin impairs the healing of the ureteric anastomosis
- Effects of Rapamycin on the early development of zebrafish (Danio rerio)
- The combination of arsenic trioxide and Rapamycin has potent inhibitory effects on acute myeloid leukemia (AML) cells
- avb3-integrin-targeted paramagnetic nanoparticles deliver Rapamycin into the vascular wall and inhibit stenosis following balloon injury
- Treatment of lesions with a high risk of stenosis. comparative study in 300 patients of Rapamycin-and paclitaxel-eluting polymer-based stents, and bare metal stents
- Rapamycin Has Biological Activity in a Subset of Patients with Myelodysplastic Syndrome-Results of a Phase I/II Trial.
- Effect of Mycophenolic Acid and Rapamycin on the Proliferation of Glomerular Mesangial Cell of Rat
- Regulation of the mammalian target of Rapamycin complex 2 (mTORC2)
- Rapamycin NOT CYCLOSPORINE INDUCES REGULATORY CD8+ FOXP3+ CELLS.
- Comparison of the effects of Rapamycin-eluting stent implantation and coronary artery bypass grafting in treatment of patients with multi-vessel coronary disease
- Glucose-stimulated DNA Synthesis through Mammalian Target of Rapamycin (mTOR) Is Regulated by KATP Channels
- Subretinal sustained delivery of Rapamycin in the rabbit eye
- Constitutive Activation of Akt and mTOR by Flt3 Internal Tandem Duplications Mediates Myeloid Leukemogenesis and Can Be Inhibited by Rapamycin.
- Long-term clinical efficiency of endovascular treatment using Cypher Rapamycin-eluting stents in patients with coronary heart disease
- DOES Rapamycin EFFECT WOUND HEALING?
- Successful retransplantation using Rapamycin in a patient with previous calcineurin inhibitor-induced posterior leukoencephalopathy syndrome.
- Rapamycin inhibits the development of gallbladder adenocarcinoma in BK5. erbB2 transgenic mice
- Rapamycin disruption of mTOR-mLST8-raptor complex inhibits cell motility
- In vitro Rapamycin and costimulation generates Th1/Tc1 or Th2/Tc2 central memory effectors: Differential regulation by in vivo Rapamycin after allogeneic BMT
- Effect of combination of curcumin and Rapamycin on proliferation of rat glomerular mesangial cells
- Signaling by Target of Rapamycin Proteins
- Distinct mechanisms by which low and high Rapamycin doses raise plasma triglycerides in guinea pigs
- Everolimus: a classical mammalian target of Rapamycin inhibitor?
- Murine Ultrasonography Confirms That Rapamycin Is Effective Against Autoimmune Lymphoproliferative Syndrome (ALPS).
- STABILIZATION OF LONG-TERM PEDIATRIC RENAL ALLOGRAFTS WITH Rapamycin.
- A tissue selective Rapamycin analog inhibits MDA-MB-231 breast cancer cell-induced osteolytic bone metastases in nude mice
- Rapamycin throws a master switch.
- Rapamycin-CUSTOMIZED DENDRITIC CELLS ARE RESISTANT TO MATURATION INDUCED BY CD40 LIGATION—A CONDITION PIVOTAL TO THEIR …
- USE OF Rapamycin IN CHILDREN POST LIVER TRANSPLANTATION
- Mammalian Target of Rapamycin inhibition Synergistically Increases Cytotoxicity of Vinorelbine in Breast Cancer Cells.
- The role of caspase-3 in Rapamycin-induced apoptosis of hepatocellular carcinoma BEL-7402 cells
- Enhanced Killing of Chronic Myelogenous Leukemia Cells by Rapamycin and Imatinib Is Associated with Differential inhibition of 4E-BP1 and eIF4E Phosphorylation …
- Rapamycin Induces Balb/C Murine CD4+CD25+Foxp3+ T Cells Proliferations.
- Effect of locally administered Rapamycin and cyclosporin A on penetrating keratoplasty rejection rat model
- Curcumin inhibits the mammalian target of Rapamycin-mediated signaling pathways
- Bone-targeted Rapamycin analogs inhibit osteolysis and tumor growth in a PC-3-GFP intratibial bone cancer model in nude mice
- The expression of mammalian target of Rapamycin and its substrates in autogenous vein graft in rats
- Effects of Rapamycin on Notch1/Jagged1 signal pathway and the expression of fibronectin in TGF-β, induced rat renal intertitial fibroblasts [J]
- The mTOR Inhibitor Rapamycin Inhibits Drug Transport in Multidrug Resistant Cell Lines and in Acute Myeloid Leukemia (AML) Cells.
- Effect of Rapamycin on Corneal Neovascularization
- THE EFFECT OF Rapamycin ON BILE DUCT HEALING
- Safety and efficacy comparison between Rapamycin-eluting stent with biodegradable polymer or permanent polymer in patients with coronary artery disease
- Rapamycin added to human CD25+ cell cultures activated through CD3/CD28 enriches for CD4+ CD25+ CD27+ Foxp3+ regulatory T cells
- Effect of Mycophenolic Acid and Rapamycin on the Proliferation and Collagen Synthesis of the Vascular Smooth Muscle Cell of Rat
- Two-year experience with Rapamycin in kidney transplantation
- Effects of Rapamycin on the function of human dendritic cells
- Effects of Rapamycin on Rho-kinase and p27 mRNA expressions in a porcine coronary intimal proliferation model induced by interleukin-1beta
- IN CONTRAST TO CYCLOSPORIN, Rapamycin SPARES FOXP3+ CD4+ T-CELLS IN VIVO.
- Rapamycin THERAPY IN PANCREAS ALLOGRAFT RECIPIENTS
- Sustained Rapamycin drug delivery system in prevention of high risk corneal allograft rejection and neovascularization in rabbits
- The role of GSK3β in Rapamycin-mediated cell cycle regulation
- Rapamycin Treatment Results in GATA
- Possible molecular target therapy with Rapamycin in MDS
- Blocking mTOR by Rapamycin reduces HIF-1α function in human gastric cancer cells in vitro and inhibits angiogenesis and tumor growth in vivo
- Influence of CTLA4Ig combined with Rapamycin on the survival of renal allografts in rats
- Combination therapy of bevacizumab with Rapamycin in antitumor activity.
- EVALUATION OF APOPTOSIS IN PERIPHERAL HUMAN LYMPHOCYTES EXPOSED TO Rapamycin.
- … IN CHRONIC ALLOGRAFT NEPHROPATHY (CAN) FOLLOWING CALCINEURIN INHIBITORS (CNI) WITHDRAWAL AND CONVERSION TO Rapamycin.
- Application of Rapamycin in the patients with liver injury following renal transplantation: a report of 7 cases
- Establishment of a Rapamycin-resistant cell line that retains sensitivity to PI3 kinase inhibitors.
- mTOR (mammalian target of Rapamycin) inhibition with RAD001 induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitizes DLBCL cells to …
- A Novel Serum-Stable Micelle System for Controlled Release of Rapamycin
- The effects of Rapamycin for the chole-sterol rabbits after balloon injury
- Effect of New Immunosuppressant-Rapamycin on One-Way Mixed Lymphocyte Culture
- inhibition of repopulation is not a determining factor for the radiosensitizing effects of Rapamycin
- Antitumor efficacy of Rapamycin derivertive RAD001 in human ovarian cancer
- Dendritic cells, Rapamycin and transplant tolerance
- Troglitazone Exerts a Cell-Dependent Effect on the Extracellular Secretion of VEGF165 Independently from the Rapamycin Sensitivity or the Level of eIF4E …
- Rapamycin inhibited the growth of hepatocellular carcinoma in nude mice
- Rapamycin-Eluting Stents for the Treatment of In-Stent Restenosis
- Effect of Rapamycin on Renal Ischemia Reperfusion Injury
- Mutant type glutathione S-transferase theta 1 gene homologue to mTOR in myelodysplastic syndrome: possible clinical application of Rapamycin
- A RARE CASE OF Rapamycin INDUCED SECRETORY DIARRHEA IN A LIVER TRANSPLANT PATIENT: 544
- Clinical application of domestic Rapamycin-eluting stents in coronary heart disease patients
- The Studies of Antitumor Effect of Rapamycin on Human Hepatocellular Carcinoma BEL-7402 Cells in vitro
- Investigation of the Function and Regulatory Mechanisms of the Mammalian Target of Rapamycin
- New progress of Rapamycin in prevention and treatment of chronic allograft nephropathy
- Mammalian Target of Rapamycin (mTOR)
- Rapamycin treatment during fractionated radiotherapy causes cell death in 3D culture
- 18F-Labeled analog of Rapamycin for PET imaging
- Rapamycin-SENSITTVE SIGNAL TRANSDUCTION PATHWAYS AND THE CONTROL OF ADIPOGENESIS
- Therapeutic effect of Rapamycin in the treatment of malignancies in recipients after kidney transplantation
- Sirolimus (Rapamycin) impairs renal function
- Rapamycin INHIBITS NK CELL FUNCTION
- … WITH THYMOGLOBULIN/ZENAPAX INDUCTION, TACROLIMUS AND STEROID MAINTENANCE, COMPARING Rapamycin WITH MYCOPHENOLATE MOFETIL …
- Rapamycin modifies the vascular tone of rat isolated aortas
- Rapamycin-INDUCED PROTEINURIA: INCIDENCE, OUTCOME AND THERAPEUTIC HANDLING.
- Prolonged survival of renal allografts with domestic Rapamycin in rats [J]
- … FUNCTIONS OF REGULATORY T CELLS, LEADING, IN CONJUNCTION WITH A BRIEF SUB-THERAPEUTIC COURSE OF Rapamycin, TO ROBUST, DONOR …
- Clinical Benefits of Rapamycin-Eluting Stent Implantation in Patients With Acute Coronary Syndromes
- The role of phosphorylation in the regulation of the mammalian target of Rapamycin.
- The clinical effect of homemade Rapamycin-eluting stent on acute myocardial infarction
- Regulation of skeletal muscle differentiation by a Rapamycin-sensitive signaling pathway
- THE MAMMALIAN TARGET OF Rapamycin (mTOR) AS A TARGET FOR CANCER CHEMOTHERAPY
- Combination therapy targeting hypoxia inducible factor-α (HIF-1 α) and Tissue Factor (TF) by the mTOR inhibitor Rapamycin and the histone deacetylase inhibitor …
- Rapamycin is efficacious against gliomas and acts as an anti-VEGF and anti-invasion agent
- DIFFERENT FUNCTIONAL, HISTOLOGICAL AND INMUNOHISTOCHEMICAL PATTERNS INDUCED BY THE ASSOCIATION OF Rapamycin WITH FK506 OR …
- Orally Administered Rapamycin Can Inhibit Myointimal Hyperplasia: Should It Be Used?
- Effects of Rapamycin-eluted stent on platelet function in patients with coronary heart disease
- Regulation of the GATA-type transcription factor Gln3p by the target of Rapamycin protein (TOR).
- Combination of Rapamycin and somatostatin analogues for the treatment of nonfunctioning pituitary tumors
- The experimental study on the effects of Rapamycin and statin on chronic transplant vasculopathy
- Rapamycin targets Cyclin/Cdk/p21/PCNA complexes and Cyclin D1 reverses Rapamycin action by stabilizing these complexes
- Rapamycin conversion for immunosuppressive therapy in the setting of renal insufficiency in patients with heart transplantation: pilot observations
- Inhibitory Effect of Rapamycin on Corneal Neovascularization induced by Angiogenin in Rabbits
- NURSING IMPLICATIONS REGARDING THE MANAGEMENT OF SIDE EFFECTS IN A PHASE I STUDY USING GEFITINIB WITH Rapamycin.
- Clinical Contrast Investigation of Rapamycin Eluting Stent between Chinese Making and Imported
- The role of mammalian target of Rapamycin (mTOR) in a rat model of autoimmune myocarditis
- Effect of Rapamycin on Mouse Chronic Lymphocytic Leukemia and the Development of Nonhematopoietic Malignancies in Em-TCL1 Transgenic Mice
- Overview of Therapeutic Potential of Rapamycin for Coronary Artery Diseases in the Era of the Drug-Eluting Stent
- Rapamycin-Sensitive Signal Transduction Pathways and the Control of Adipogenesis
- Rapamycin for Cardiac Transplant Rejection and Vasculopathy
- Rapamycin synergistically enhances the cytotoxicity of paclitaxel in breast cancer cells
- Oral Rapamycin attenuates progression of atherosclerotic plaque in ApoE knockout mice
- Clinical Research of Rapamycin-Eluting Stent in Treatment of Multi-Vessel Coronary Disease
- Rapamycin inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cells
- Biocompatibility of Rapamycin-Batroxobin Eluting Stent in Porcine Coronary Artery
- Effect of Rapamycin on anti-HLA donor antibody formation in patients with transplant coronary artery disease
- Combination of the mTOR Inhibitor Rapamycin and Revlimid™(CC-5013) Has Synergistic Activity in Multiple Myeloma (MM).
- Characterization of the FKBP·Rapamycin·FRB Ternary Complex [J. Am. Chem. Soc. 2005, 127, 4715−4721].
- Is there a role for oral Rapamycin in restenosis prevention after bare-metal stent implantation?
- Isolation and Genetic Analysis of Rapamycin-sensitive mutants in Aspergillus nidulans.
- Overexpression of the Bad mutant (S112A) partially disrupts the ability of IGF-I to protect cells from Rapamycin-induced apoptosis
- One year effect of Rapamycin eluting stent in patients with coronary heart disease
- The role of mammalian target of Rapamycin (mTOR) in insulin resistance
- Rapamycin AND SANGLIFEHRIN A CAN INHIBIT INTERLEUKIN-18 PRODUCTION FROM DENDRITIC CELLS IN VITRO AND IN VIVO.
- MRI detection of Rapamycin and AP-Cav therapeutic rescue from endothelial over expression of Akt in transgenic mice
- SENSITIVITY OF HUMAN METASTATIC MELANOMA CELLS TO THE ESTER ANALOG OF Rapamycin, CCI-779
- Synergistic growth inhibition by Iressa and Rapamycin in Renal Cell Carcinoma (RCC) with wild-type VHL
- Six-month results of a biodegradable polymer and Rapamycin-coating stent for coronary artery disease
- The mTOR inhibitor, Rapamycin, inhibits growth of Ewing’s sarcoma in vitro and in vivo
- EEEICACY AND SAFETY OF Rapamycin-BASED IMMUNOSUPPRESSION REGIMEN WITH OR WITHOUT CSA IN RENAL TRANSPLANTATION: A SYSTEMATIC …
- Rapamycin Inhibits Rabbit Corneal Neovascularization Induced by Angiogenin
- Preclinical analysis of Rapamycin plus EGFR or MEK1/2 inhibitors in renal cell carcinoma (RCC)
- Effect of Rapamycin (RPM) on interleukin-10 gene expression in rats with postburn Staphylococcus aureus sepsis
- Effect of Rapamycin on mouse CLL and development of non-hematopoietic malignancies in Eμ-TCL1 transgenic mice
- Effect of isoflavones alone and in combination with Rapamycin on mTOR pathway in human glioblastoma cells (U87).
- Rapamycin INHIBITS THE SPONTANEOUS FORMATION OF DE NOVO CANCER IN P53 KNOCKOUT MICE.
- Urokinase-induced smooth muscle cell migration involves the mammalian target of Rapamycin
- Importance of mammalian target of Rapamycin inhibitors in the prevention of cardiac allograft vasculopathy
- Rapamycin enhances the number and function of alloantigen-induced human CD103+CD8+ regulatory T cells in vitro
- Clinical contrast investigation of Rapamycin eluting stent between Chinese making and imported in the treatment of coronary artery disease
- Rapamycin inhibits activation of STAT3 in renal tissue of IgA nephropathy rats
- The mTOR inhibitor Rapamycin inhibits proadhesive activity of arterial intimal smooth muscle cells
- Identification of a highly effective Rapamycin schedule that markedly reduces the size, multiplicity and phenotypic progression of tobacco carcinogen-induced murine …
- Mammals Target Protein of Rapamycin (mTOR) Expression in Adult Acute Myeloid Leukemia Patients
- A Randomized Comparison Between Paclitaxel-Eluting Stents and Rapamycin-Eluting Stents for Patients With Coronary Artery Diseases
- Silencing mTOR signal by small interfering RNA enhances Rapamycin-induced autophagy in malignant glioma cells.
- CYCLOSPORINE AND Rapamycin ACT IN A SYNERGISTIC AND DOSE-DEPENDENT MANNER IN A MODEL OF IMMUNOSUPPRESSANT-INDUCED KIDNEY …
- The role of the mammalian target of Rapamycin (mTOR) in long term potentiation
- Nursing intervention of chronic renal diseases patients orally taking Rapamycin after underwent kidney transplantation [J]
- The effect of Rapamycin after cyclosporin dose reduction on chronic allograft nephropathy
- The Saccharomyces Cerevisiae Phosphatase Activator YPTPA1/RRD1 is Required to Modulate Gene Expression in Response to Rapamycin Exposure
- COMBINATION OF Rapamycin PLUS MUTANT TGF-b/Fc TO INDUCE IMMUNE TOLERANCE.
- Effect of Akt (PKB) on the activity of mammalian target of Rapamycin (mTOR)
- Effect of Rapamycin Eluting Stent on Level of C-reactive Protein in Patients with Acute Coronary Syndrome After Angioplasty [J]
- PI3K and mTOR signalling pathways: perspectives for Rapamycin and its derivatives as antineoplastic targeted therapies
- Effectiveness and safety of Rapamycin-based immunosuppression regimens on preserving or withdrawing CsA in renal transplantation: a systematic review
- The modulation of neointimal proliferation and p27 kip expression after implanting Rapamycin-eluting stents in the porcine coronary model
- Different released Rapamycin eluting stents to reduce in-stent neointimal hyperplasia in a porcine coronary model
- CHIMERISM PLAYS AN ACTIVE ROLE IN TRANSPLANTATION TOLERANCE INDUCED BY ALS, Rapamycin AND DONOR BONE MARROW INFUSION
- Effect of Biodegradable Rapamycin-Eluting Stent on Neointimal Proliferation in Porcine Coronary Artery Model
- Rapamycin INHIBITS IL-10 INDUCTION BY LATENT MEMBRANE PROTEIN 1 OF EPSTEIN BARR VIRUS.
- Editorial [Hot Topic: Mammalian Target of Rapamycin as a Therapeutic Target in Leukemia (Executive Editors: Francis J. Giles/Maher Albitar)]
- A Gene Expression Connectivity Map Identifies Rapamycin as a Glucocorticoid Resistance Reversal Agent in Lymphoblastic Leukemia.
- Rapamycin-sensitive TOR signaling regulates intestinal growth and morphogenesis in zebrafish
- TARGET OF Rapamycin (TOR) MEDIATES THE ENDODERM-INTESTINE TRANSITION IN ZEBRAFISH: 68
- Lactic-co-glycolic acid polymer with Rapamycin coated stent reduces neo-intimal formation in a porcine coronary model
- The mammalian target of Rapamycin controls cell motility through its effectors S6K1 and 4E-BP1
- SAFETY AND EFFICACY OF A STEROID-FREE REDUCED-DOSE NEORAL/Rapamycin MAINTENANCE IMMUNOSUPPRESSION IN RENAL TRANSPLANTATION …
- inhibition of mTOR signaling with Rapamycin attenuates renal hypertrophy in the early diabetic mice
- Combinations of Cytotoxic Drugs, Ionizing Radiation, and Mammalian Target of Rapamycin (mTOR) Inhibitors
- Effects of stent-based delivery of Rapamycin and methotrexate on neointimal formation in a porcine coronary model
- Rapamycin MANIPULATION OF HOST-DERIVED, ALLOANTIGEN-PULSED DENDRITIC CELLS PLUS POSTOPERATIVE Rapamycin, BUT NOT FK506 …
- Ex Vivo Rapamycin Generates Th2 Cells with Enhanced Mitochondrial Function and Reduced Apoptosis Via Intrinsic and Extrinsic Pathways.
- combination with the immunosuppressive drug Rapamycin, seems to forestall rejection in mice. Transferring this protocol to the human clinic should be fairly straight …
- Rapamycin-generated CD4+, Th2 cells modulate graft-versus-host reaction via an IL-4 dependent mechanism
- The assessment of human islets for transplantation and the effect of the immunosuppressant Rapamycin on MIN-6 cells, rat and human islets
- 549: The Effect of Rapamycin Immunosuppression on Native Polycystic Kidney Volumes in Renal Transplant Patients
- Calcineurin inhibitors but not Rapamycin abrogate activation of the immunomodulatory enzyme indoleamine 2, 3-dioxygenase.
- Translational control of gene expression in rat liver in relation to mammalian target of Rapamycin signaling
- Rapamycin Protects Allografts From Rejection While Simultaneously Attacking Tumors in Immunosuppressed Mice
- Rapamycin and IL-10 induce Ag-specific T regulatory type 1 cells (Tr1) and b-islet allograft tolerance in diabetic mice
- In Vitro and in Vivo Cyclosporine-Induced Tumor Angiogenesis and Tumor Growth Are Blocked By Simultaneous Application of Rapamycin
- Rapamycin INHIBITS EPSTEIN BARR VIRUS+ B CELL LYMPHOMA THROUGH MODULATION OF CELL CYCLE PROTEIN EXPRESSION.
- Newly identified kit ITD in childhood AML induces ligand independent growth and is responsive to a synergistic effect of imatinib and Rapamycin
- Effects of the immunomodulatory drugs tacrolimus, Rapamycin and cilomilast on dendritic cell function in a model of allergic contact dermatitis
- Rapamycin exerts an anti-inflammatory action in vitro and in vivo by inducing monocyte apoptosis and modulating cytokine/chemokines secretion
- Site specific systemic delivery of Rapamycin with perfluorobutane gas microbubble carrier reduced neointimal formation in the porcine coronary restenosis model
- Rapamycin sensitizes tumor cells to chemotherapy-induced apoptosis and induces cell cycle arrest in ALK+ anaplastic large cell lymphoma.
- Sustained Rapamycin Drug Delivery System for Prevention of High Risk Corneal Allograft Rejection and Neovascularization in Rabbits
- Everolimus Is Comparably Effective to Rapamycin Acting Synergistically with Imatinib in the Treatment of Constitutively Active Mutations of the Juxtamembrane …
- Unrestricted Utilization of Sirolimus-Eluting Stents in the “Real World”: The Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital …
- Serotonin-mediated activation of Rapamycin-sensitive S6 kinase-S6 ribosomal protein signal transduction pathway in synaptosomes.
- Rapamycin INHIBITS EPSTEIN BARR VIRUS+ B CELL LYMPHOMA PROLIFERATION THROUGH MODULATION OF CELL CYCLE PROTEIN EXPRESSION.
- Effects of Rapamycin Eluting Stents on Blood Tissue Factor and Tissue Factor Pathway Inhibitor in Patients With Acute Coronary Syndromes
- DONOR SPECIFIC TRANSFUSION COMBINED WITH Rapamycin PROLONGED THE CARDIAC GRAFT SURVIVAL IN MICE.
- Activity of panitumumab plus Rapamycin against wild type (WT) and mutant epidermal growth factor receptor (EGFr)-expressing NSCLC xenografts
- TACROLIMUS DECREASES, CYCLOSPORINE INCREASES, AND Rapamycin HAS NO EFFECT ON PROFIBROTIC GENE MRNA EXPRESSION IN RENAL …
- Rapamycin Generated Murine Th2/Tc2 Cells Potently Abrogate Fully MHC-Mismatched Hematopoietic Stem Cell (HSC) Graft Rejection.
- 548: inhibition of the mTOR Pathway by Rapamycin Reverses Renal Cystogenesis in Polycystic Kidney Disease Models
- The mTOR inhibitor Rapamycin inhibits p27 protein degradation by downregulating the expression of its ubiquitin ligase Skp2 in breast cancer
- Induction of apoptosis in Ewing’s Sarcoma cells by simultaneous treatment with antisense oligodeoxynucleotides (AS-ODNs) to the EWS/FLI-1 gene and Rapamycin
- Construction of eukaryotic expression vector of mammalian target of Rapamycin antisense RNA and its expression in vascular smooth muscle cell
- INFLUENCE OF IMMUNOPHILLINS INHIBITORS–CYCLOSPORINE-A, TACROLIMUS AND Rapamycin–ON INSULIN SECRETION IN HEART TRANSPLANT …
- Targeting the ICOS-B7h Costimulatory Pathway Synergizes with Rapamycin to Regulate Alloresponses in Islet Transplantation: 0102
- Short and long-term therapeutic effects of Rapamycin-eluting stent and paclitaxel-eluting stent in treatment of coronary disease with complicated lesions
- The Immunomodulatory Agent Rapamycin Potentiates the Antiviral Activity of the Fusion Inhibitor T20 Against R5 Strains of HIV-1
- Binding of mTOR (Mammalian Target of Rapamycin) to the Raptor-eIF4E-4EBP1 complex changes during myogenic differentiation.
- COMBINATION OF Rapamycin AND ANTI-LFA-1 PREVENTS REJECTION OF RAT ISLET XENOGRAFTS.: 042
- Hypoxia and Rapamycin induced changes to the cell cycle of multicellular spheroids and human tumour xenografts leading to potential therapeutic advantage
- 1853: A Propsective Study With Thymoglobulin/Daclizumab Induction, Tacrolimus and Steroid Maintenance, Comparing Rapamycin With Mycophenolate Mofetil as …
- Anti-angiogenic and immunomodulatory effects of Rapamycin on pancreatic islet endothelial cells: relevance for islets engraftment after transplantation
- A comparison study on FTY720, 40-O-(2-hydroxyethyl)-Rapamycin and cyclosporine to prolong the survival of mouse heart allograft
- Role of p53 in TRAIL-induced apoptosis in glioblastoma multiforme and modulation by taxol, Rapamycin or temozolomide
- DIFFERENTIAL EFFECT OF CALCINEURIN INHIBITORS, ANTI-CD25 ANTIBODIES AND Rapamycin ON THE INDUCTION OF FOXP3 IN HUMAN T-CELLS IN VIVO …
- … mechanisms regulating proliferation, antigen responsiveness, and differentiation of CD4⁺ T lymphocytes: a central role for the mammalian target of Rapamycin (mTOR …
- Overexpression of a critical target of Rapamycin, translation regulatory protein 4E-BP1, is largely restricted to locally advanced breast and prostate cancers and is lost …
- Receptor activator of NF-kB (RANK) and its ligand RANK-L coincide with expression of Rapamycin receptor FKBP12 in neointimal dendritic cells
- The PI3K inhibitor LY294002 and the mTOR inhibitor Rapamycin sensitize melanoma cells to cisplatin and temozolomide
- Rapamycin and Anti-LFA-1 Monoclonal Antibody Prevent the Rejection of Rat Islet Xenografts and Induce Tolerance in BALB/c Mice
- Glucagon Represses Insulin Signaling through Mammalian Target of Rapamycin (mTOR) in Perfused Rat Liver
- MYCOPHENOLATE MOFETIL (MMF)/Rapamycin (RAPA) COMPARED TO OTHER COMMON IMMUNOSUPPRESSIVE REGIMENS IN KIDNEY …
- Ras Homologue Enrich in Brain (Rheb) Enhances Hypertrophic Response via the Mammalian Target of Rapamycin (mTOR)/p70S6K Pathway
- … OF HUMAN BONE MARROW DERIVED MESENCHYMAL PROGENITORS—A SIGNAL TRANSDUCTION BASE FOR PLEIOTROPY OF Rapamycin DERIVATES.
- grammed autophagy in the fat body during the final larval stage. TOR (target of Rapamycin) kinases, the central components of a conserved nutri-ent-sensing …
- ANTI-CD25 MAB, ANTI-IL2 MAB AND IL2 BLOCK TOLERANCE INDUCTION THROUGH ANTI-CD154 MAB AND Rapamycin IN XENOGENEIC ISLET …
- Schedule-dependent activity of combined epidermal growth factor receptor (EGFR) and mammalian target of Rapamycin (mTOR) targeting in PTEN negative breast …
- Differential effects of the immunosuppressive agents cyclosporine A, Rapamycin and FK-506 on drug transport by the ATP-binding cassette (ABC) proteins P …
- Amino acid transporter ASCT2 expression regulates mammalian Target‐of‐Rapamycin (mTOR) growth and survival signaling in human hepatoma cells
- … WITHDRAWAL (PW) TRIAL IN KIDNEY TRANSPLANT PATIENTS TREATED WITH MYCOPHENOLATE SODIUM (MS) COMPARING Rapamycin® VS. C2 DOSED …
- Rapamycin AND ANTI-LFA-1 THERAPY MEDIATE ISLET GRAFT SPECIFIC TOLERANCE IN CONCORDANT XENOGENEIC ISLET TRANSPLANTATION.
- PHARMACOKINETICS OF ONCE A DAY DOSE OF CYCLOSPORINE IN COMBINATION WITH Rapamycin AND PREDNISONE IN RENAL TRANSPLANTATION IN …
- ROLE OF THE MAMMALIAN TARGET OF Rapamycin IN THE REGULATION OF SKELETAL MUSCLE PROTEIN SYNTHESIS AND eIF2B EPSILON mRNA …
- IGF-1 rescues Rapamycin-induced cell growth inhibition
- CONCOMITANT USE OF CYCLOSPORINE-A (CyA) AND Rapamycin (RAPA) WITH A CONSECUTIVE CONVERSION TO RAPA AND MYCOPHENOLATE MOFETIL …
- UP-02.50: A study of the role of insulin like growth factor 1 (IGF1) and Rapamycin sensitive signaling in an androgen independent prostate cancer cell line
- … GROWTH FACTOR RECEPTOR (EGFR) INHIBITOR GEFITINIB AND THE MAMMALIAN TARGET OF Rapamycin (mTOR) INHIBITOR EVEROLIMUS
- QUADRUPLE IMMUNOSUPPERSSIVE MAINTENANCE THERAPY USING Rapamycin, LOW-DOSE CYCLOSPORINE, MYCOPHENOLATE MOFETIL, AND …
- PJ-138 New Sesquiterpene Lactone Compared with Rapamycin Inhibits Migration Rather than Proliferation in Rat Vascular Smooth Muscle Cells
- Combination therapy targeting the EWS/FLI-1 oncogene with antisense oligonucleotides and Rapamycin induces apoptosis of Ewing’s sarcoma cells in vitro and …
- … 3-kinase; RTK, receptor tyrosine kinase; S6K, ribosomal S6 kinase; TNF-α, tumor necrosis factor α; TOR, target of Rapamycin; TSC, tuberous sclerosis complex …
- LONG-TERM LIMB ALLOGRAFT SURVIVAL USING A SHORT COURSE OF ANTI-CD45RB MONOCLONAL ANTIBODY, LF15-0195 AND Rapamycin IN A MOUSE …
- A role for HO-1 in the renal function impairment in Rapamycin-treated animals submitted to ischemic and reperfusion injury (IRI).
- Bone Morphogenetic Protein 2 (BMP-2) promotes foci formation through the activation of mammalian target of Rapamycin
- GSK-3/Rb12 Pathway as a Novel Target of Rapamycin in Prostate Cancer
- PII‐9: Improved platelet function in renal transplant patients after conversion from azathioprin to Rapamycin
- Drug-eluting stents, 5-sirolimus stents and oral Rapamycin
- Autophagic Cell Death in Leukemia Cells Regulated by Ceramide and Sphingosine-1-Phosphate through Mammalian Target of Rapamycin.
- 4-(N-Methyl-N-nitrosamino)-1 (3-pyridyl)-1-butanone (NNK) Restored the Cap-dependent Protein Translation Blocked by Rapamycin
- The Saccharomyces cerevisiae GATA-factor activators’ response to the 14-3-3 proteins, nutrient limitation, Rapamycin and MSX treatment, and cis-acting …
- 1871: Rapamycin and Ischemia on Experimental Transplant Arteriosclerosis
- 1158-52 Proteomic profiling of restenotic lesions unveils increased expression of structural proteins that are inhibited by intramural delivery of Rapamycin
- … and Activator of Transcription-1 (STAT1)-dependent Gene Transcription by Lipopolysaccharide and InterferonγIs Regulated by Mammalian Target of Rapamycin
- P-205 STUDIES ON FUNGAL SECONDARY METABOLISM USING Rapamycin AS A MOLECULAR PROBE
- Sphingosine-1-phosphate–induced smooth muscle cell migration involves the mammalian target of Rapamycin
- Rapamycin: something old, something new, sometimes borrowed and now renewed
- Rapamycin and mTOR kinase inhibitors
- Rapamycin is a neuroprotective treatment for traumatic brain injury
- Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
- Rapamycin prevents early steps of the development of diabetic nephropathy in rats
- Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
- Targeting mammalian target of Rapamycin (mTOR) for health and diseases
- A role for mammalian target of Rapamycin in regulating T cell activation versus anergy
- A rational mechanism for combination treatment of Huntington’s disease using lithium and Rapamycin
- Antitumor activity of Rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma
- Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
- The Rapamycin-binding domain of the protein kinase mammalian target of Rapamycin is a destabilizing domain
- The mammalian target of Rapamycin signaling pathway: twists and turns in the road to cancer therapy
- The mammalian target of Rapamycin complex 2 controls folding and stability of Akt and protein kinase C
- Rapamycin, a specific inhibitor of the mammalian target of Rapamycin, suppresses lymphangiogenesis and lymphatic metastasis
- Neuroprotection of Rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
- inhibition of the mammalian target of Rapamycin impedes lymphangiogenesis
- Contrasting Effects of Cyclosporine and Rapamycin in De Novo Generation of Alloantigen‐Specific Regulatory T Cells
- Metformin inhibits mammalian target of Rapamycin–dependent translation initiation in breast cancer cells
- Roles of rapH and rapG in positive regulation of Rapamycin biosynthesis in Streptomyces hygroscopicus
- Temsirolimus, an inhibitor of mammalian target of Rapamycin
- The Mammalian target of Rapamycin pathway regulates nutrient-sensitive glucose uptake in man
- Silencing mammalian target of Rapamycin signaling by small interfering RNA enhances Rapamycin-induced autophagy in malignant glioma cells
- Selective survival of naturally occurring human CD4+ CD25+ Foxp3+ regulatory T cells cultured with Rapamycin
- Mammalian target of Rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model
- Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
- mTOR inhibition by Rapamycin prevents β-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
- The mammalian target of Rapamycin-signaling pathway in regulating metabolism and growth,
- Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
- Hypoxia-inducible factor 1α is regulated by the mammalian target of Rapamycin (mTOR) via an mTOR signaling motif
- Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol
- Rapamycin treatment for a child with germline PTEN mutation
- Effect of Rapamycin alone and in combination with sorafenib in an orthotopic model of human hepatocellular carcinoma
- PRAS40 is a target for mammalian target of Rapamycin complex 1 and is required for signaling downstream of this complex
- Use of sirolimus (Rapamycin) to treat refractory Crohn’s disease
- Rapamycin affects early fracture healing in mice
- Mammalian target of Rapamycin inhibition as a therapeutic strategy in the management of urologic malignancies
- The role of hypothalamic mammalian target of Rapamycin complex 1 signaling in diet-induced obesity
- Re-evaluating the roles of proposed modulators of mammalian target of Rapamycin complex 1 (mTORC1) signaling
- Mammalian target of Rapamycin inhibitor dyslipidemia in kidney transplant recipients
- Dose-and schedule-dependent inhibition of the mammalian target of Rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with …
- Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins
- Rapamycin prevents thyroid hormone-induced cardiac hypertrophy
- Mammalian target of Rapamycin (mTOR) orchestrates the defense program of innate immune cells
- Rapamycin modulates the eNOS vs. shear stress relationship
- Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formation
- The mammalian target of Rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes
- Gonadal impact of target of Rapamycin inhibitors (sirolimus and everolimus) in male patients: an overview
- Phase I trial of the novel mammalian target of Rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to …
- Randomized trial of three Rapamycin-eluting stents with different coating strategies for the reduction of coronary restenosis
- Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the Rapamycin-sensitive PI (3) K-mTOR-p70S6K pathway
- The role of mammalian target of Rapamycin inhibitors in the treatment of advanced renal cancer
- Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and Rapamycin
- Mammalian target of Rapamycin as a therapeutic target in oncology
- Pilot study of Rapamycin in patients with hormone-refractory prostate cancer
- Regulation of androgen receptor transcriptional activity by Rapamycin in prostate cancer cell proliferation and survival
- Changes in tumor metabolism as readout for Mammalian target of Rapamycin kinase inhibition by Rapamycin in glioblastoma
- Response of a neuronal model of tuberous sclerosis to mammalian target of Rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved …
- inhibition of Mammalian target of Rapamycin by Rapamycin causes the regression of carcinogen-induced skin tumor lesions
- Chemoprevention and treatment of experimental Cowden’s disease by mTOR inhibition with Rapamycin
- Antitumor activity of Rapamycin and octreotide as single agents or in combination in neuroendocrine tumors
- In human endothelial cells Rapamycin causes mTORC2 inhibition and impairs cell viability and function
- Mammalian target of Rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
- Mammalian target of Rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation
- Differential impact of mammalian target of Rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
- Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling
- Dissecting the Akt/mammalian target of Rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative
- Rapamycin impairs in vivo proliferation of islet beta-cells
- Total synthesis of Rapamycin
- Regulation of elongation phase of mRNA translation in diabetic nephropathy: amelioration by Rapamycin
- Systemic inhibition of mammalian target of Rapamycin inhibits fear memory reconsolidation
- The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging
- Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+ CD25+ FOXP3+ regulatory T-cells
- Mammalian target of Rapamycin in the human placenta regulates leucine transport and is down‐regulated in restricted fetal growth
- The mTOR inhibitor Rapamycin significantly improves facial angiofibroma lesions in a patient with tuberous sclerosis
- Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3‐E1 cells and primary mouse bone marrow stromal cells
- Antidepressive-like effects of Rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders
- Alterations in mammalian target of Rapamycin signaling pathways after traumatic brain injury
- Regulatory effects of mammalian target of Rapamycin-activated pathways in type I and II interferon signaling
- Preparation of Rapamycin-loaded chitosan/PLA nanoparticles for immunosuppression in corneal transplantation
- Bnip3 mediates the hypoxia-induced inhibition on mammalian target of Rapamycin by interacting with Rheb
- Sirolimus (Rapamycin): from the soil of Easter Island to a bright future
- Susceptibility of human mesenchymal stem cells to tacrolimus, mycophenolic acid, and Rapamycin
- AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of Rapamycin/p70S6K1 pathway
- Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ …
- Rapamycin, not cyclosporine, permits thymic generation and peripheral preservation of CD4+ CD25+ FoxP3+ T cells
- Dietary energy balance modulates signaling through the Akt/mammalian target of Rapamycin pathways in multiple epithelial tissues
- Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/WF1 mice
- Isolation of hyperactive mutants of mammalian target of Rapamycin
- P-Rex1 links mammalian target of Rapamycin signaling to Rac activation and cell migration
- Rapamycin inhibits polyglutamine aggregation independently of autophagy by reducing protein synthesis
- Bevacizumab and Rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
- Phosphoprotein pathway mapping: Akt/mammalian target of Rapamycin activation is negatively associated with childhood rhabdomyosarcoma survival
- Delivery of Rapamycin by PLGA nanoparticles enhances its suppressive activity on dendritic cells
- Rapamycin regulates the phosphorylation of rictor
- Inhibitors of mammalian target of Rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo
- Distinct signaling mechanisms activate the target of Rapamycin in response to different B‐cell stimuli
- Therapeutic effect of Rapamycin on gallbladder cancer in a transgenic mouse model
- Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common …
- Activated mammalian target of Rapamycin is an adverse prognostic factor in patients with biliary tract adenocarcinoma
- Expression of an activated mammalian target of Rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy
- The effect of immunosuppressive drug Rapamycin on regulatory CD4+ CD25+ Foxp3+ T cells in mice
- Impact of Rapamycin on liver regeneration
- Curcumin inhibits Akt/mammalian target of Rapamycin signaling through protein phosphatase-dependent mechanism
- Combination of Rapamycin and IL-2 increases de novo induction of human CD4+ CD25+ FOXP3+ T cells
- Translational control of c-MYC by Rapamycin promotes terminal myeloid differentiation
- Rapamycin inhibits proliferation of estrogen-receptor-positive breast cancer cells
- An activated mTOR/p70S6K signaling pathway in esophageal squamous cell carcinoma cell lines and inhibition of the pathway by Rapamycin and siRNA against …
- Mammalian target of Rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids
- Evaluation of antileukaemic effects of Rapamycin in patients with imatinib‐resistant chronic myeloid leukaemia
- Antiproliferative effects of Rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines
- Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling
- Mammalian target of Rapamycin: master regulator of cell growth in the nervous system
- Binding of Rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
- Epstein Barr virus, Rapamycin, and host immune responses
- Regression of subependymal giant cell astrocytoma with Rapamycin in tuberous sclerosis complex
- Effect of Rapamycin on wound healing: an experimental study
- Saccharomyces cerevisiae FKBP12 binds Arabidopsis thaliana TOR and its expression in plants leads to Rapamycin susceptibility
- ASCT2 silencing regulates mammalian target-of-Rapamycin growth and survival signaling in human hepatoma cells
- Small molecule enhancers of Rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington’s disease models and enhance killing of …
- Mammalian target of Rapamycin (mTOR) is involved in the neuronal differentiation of neural progenitors induced by insulin
- Defects in skin γδ T cell function contribute to delayed wound repair in Rapamycin-treated mice
- Effective in vivo targeting of the mammalian target of Rapamycin pathway in malignant peripheral nerve sheath tumors
- Rapamycin, but not cyclosporine or FK506, alters natural killer cell function
- IL-1β-driven ST2L expression promotes maturation resistance in Rapamycin-conditioned dendritic cells
- Mitogen-activated protein kinase upregulates the dendritic translation machinery in long-term potentiation by controlling the mammalian target of Rapamycin pathway
- CXCR6 induces prostate cancer progression by the AKT/mammalian target of Rapamycin signaling pathway
- Combination strategy targeting the hypoxia inducible factor-1α with mammalian target of Rapamycin and histone deacetylase inhibitors
- Pharmacometrics and delivery of novel nanoformulated PEG-b-poly (ε-caprolactone) micelles of Rapamycin
- Calcineurin inhibitors and Rapamycin: cancer protection or promotion?
- A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of Rapamycin (mTOR) in high-protein diet–induced weight loss
- … exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of Rapamycin …
- Endoplasmic reticulum and Golgi localization sequences for mammalian target of Rapamycin
- Mammalian target of Rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute …
- Rapamycin inhibits cell growth by induction of apoptosis on hepatocellular carcinoma cells in vitro
- Identification of a Highly Effective Rapamycin Schedule that Markedly Reduces the Size, Multiplicity, and Phenotypic Progression of Tobacco Carcinogen–Induced …
- Rapamycin prevents the development of nephritis in lupus-prone NZB/WF1 mice
- Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by Rapamycin
- Rapamycin as an inhibitor of osteogenic differentiation in bone marrow-derived mesenchymal stem cells
- Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice
- Intramural Delivery of Rapamycin With αvβ3-Targeted Paramagnetic Nanoparticles Inhibits Stenosis After Balloon Injury
- FK506 binding protein mediates glioma cell growth and sensitivity to Rapamycin treatment by regulating NF-κB signaling pathway
- Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: Rapamycin triggers dephosphorylation and delocalization of the mTORC2 …
- Oncogenic tyrosine kinase NPM/ALK induces activation of the Rapamycin-sensitive mTOR signaling pathway
- Target of Rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine
- Antiangiogenic therapy with mammalian target of Rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer
- Mammalian target of Rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy
- Preparation and characterization of Rapamycin-loaded PLGA coating stent
- Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and Rapamycin induces growth arrest of adult T-cell leukemia cells
- Suppression of Peutz-Jeghers polyposis by targeting mammalian target of Rapamycin signaling
- Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor with potent in …
- Rapamycin retards growth and causes marked alterations in the growth plate of young rats
- … fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of Rapamycin (mTOR) signaling cascade
- Autophagy activation by Rapamycin eliminates mouse Mallory‐Denk bodies and blocks their proteasome inhibitor‐mediated formation
- Mammalian target of Rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancer
- Defective TGF-β signaling sensitizes human cancer cells to Rapamycin
- A retroinhibition approach reveals a tumor cell–autonomous response to Rapamycin in head and neck cancer
- Effects of Rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons
- inhibition of mammalian target of Rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E …
- Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of Rapamycin in mammary carcinomas, mammary gland …
- Targeting Protein Translation in Human Non–Small Cell Lung Cancer via Combined MEK and Mammalian Target of Rapamycin Suppression
- Activation of mammalian target of Rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes
- … concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of Rapamycin/eIF4E …
- Enhancing mammalian target of Rapamycin (mTOR)–targeted cancer therapy by preventing mTOR/Raptor inhibition-initiated, mTOR/Rictor-independent Akt activation
- Leucine stimulates mammalian target of Rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphate-activated protein kinase
- Rapamycin Inhibits Proliferation of Epstein-Barr Virus–Positive B-cell Lymphomas Through Modulation of Cell-Cycle Protein Expression
- Solution structure of the Legionella pneumophila Mip-Rapamycin complex
- Combined therapeutic effects of vinblastine and Rapamycin on human neuroblastoma growth, apoptosis, and angiogenesis
- Azoospermia in a renal transplant recipient during sirolimus (Rapamycin) treatment
- Differential involvement of IκB kinases α and β in cytokine-and insulin-induced mammalian target of Rapamycin activation determined by Akt
- The role of targeting mammalian target of Rapamycin in lung cancer
- Amelioration of protein misfolding disease by Rapamycin: translation or autophagy?
- Monitoring biological action of Rapamycin in renal transplantation
- Efficacy of Rapamycin in scleroderma: a case study
- Statin therapy, alone or with Rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study
- Target of Rapamycin and LST8 proteins associate with membranes from the endoplasmic reticulum in the unicellular green alga Chlamydomonas reinhardtii
- Regulation of mammalian target of Rapamycin activity in PTEN-inactive prostate cancer cells by IκB kinase α
- … regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of Rapamycin
- The Akt/mammalian target of Rapamycin signal transduction pathway is activated in high-risk myelodysplastic syndromes and influences cell survival and proliferation
- The mammalian target of Rapamycin pathway as a potential target for cancer chemoprevention
- Rapamycin: brain excitability studied in vitro
- Rapamycin‐mediated G1 arrest involves regulation of the Cdk inhibitor Sic1 in Saccharomyces cerevisiae
- Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion
- Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of Rapamycin pathway
- Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of Rapamycin signalling to protein synthesis in L6 muscle cells
- Phosphorylation of ribosomal p70 S6 kinase and Rapamycin sensitivity in human colorectal cancer
- Mammalian Target of Rapamycin Repression by 3, 3′-Diindolylmethane Inhibits Invasion and Angiogenesis in Platelet-Derived Growth Factor-D–Overexpressing …
- Endothelial Akt signaling is rate-limiting for Rapamycin inhibition of mouse mammary tumor progression
- Aging, stem cells, and mammalian target of Rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells
- The mammalian target of Rapamycin kinase and tumor growth inhibition
- Nonimmunosuppressive effects of mammalian target of Rapamycin inhibitors
- Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro
- Interplay of PI3K and cAMP/PKA signaling, and Rapamycin-hypersensitivity in TGFβ1 enhancement of FSH-stimulated steroidogenesis in rat ovarian …
- … human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase–dependent mammalian target of Rapamycin raptor complex 1 …
- mTOR is the Rapamycin-sensitive kinase that confers mechanically-induced phosphorylation of the hydrophobic motif site Thr (389) in p70S6k
- Oncolytic virotherapy synergism with signaling inhibitors: Rapamycin increases myxoma virus tropism for human tumor cells
- Juvenile hormone connects larval nutrition with target of Rapamycin signaling in the mosquito Aedes aegypti
- Rapamycin suppresses TLR4-triggered IL-6 and PGE2 production of colon cancer cells by inhibiting TLR4 expression and NF-κB activation
- Protein phosphatase 2A and Rapamycin regulate the nuclear localization and activity of the transcription factor GLI3
- Effect of Rapamycin therapy on coronary artery physiology early after cardiac transplantation
- Low-dose mTOR inhibition by Rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat
- Immunosuppression and tumor development in organ transplant recipients: the emerging dualistic role of Rapamycin
- Bevacizumab and Rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer
- Effects of the dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging
- IL-2– and IL-15–induced activation of the Rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes
- Mammalian Target of Rapamycin (mTOR) is Activated in Cutaneous Vascular Malformations in Vivo
- Reduction of CCR5 with low-dose Rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1
- Evaluation of the mammalian target of Rapamycin pathway and the effect of Rapamycin on target expression and cellular proliferation in osteosarcoma cells from dogs
- Differential effects of Rapamycin in anti-GBM glomerulonephritis
- Rapamycin inhibits PAI-1 expression and reduces interstitial fibrosis and glomerulosclerosis in chronic allograft nephropathy
- Coupling of mammalian target of Rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2a-and glycogen synthase …
- Mammalian target of Rapamycin and caspase inhibitors in polycystic kidney disease
- Pharmacodynamic-guided modified continuous reassessment method–based, dose-finding study of Rapamycin in adult patients with solid tumors
- Statin-dependent suppression of the Akt/mammalian target of Rapamycin signaling cascade and programmed cell death 4 up-regulation in renal cell carcinoma
- Impact of mammalian target of Rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic …
- Antiproliferative and proapoptotic effects of Rapamycin and celecoxib in malignant melanoma cell lines
- Role of the phosphoinositide 3-kinase-Akt-mammalian target of the Rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat …
- Exploiting the mammalian target of Rapamycin pathway in hematologic malignancies
- Simultaneous hybrid coronary revascularization using totally endoscopic left internal mammary artery bypass grafting and placement of Rapamycin eluting stents in the …
- Degradation of Rapamycin and its ring-opened isomer: role of base catalysis
- Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21WAF1/CIP1 expression with Rapamycin
- Superoxide anions regulate TORC1 and its ability to bind Fpr1: Rapamycin complex
- The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of Rapamycin complex 1
- Topical Rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model
- Cardiac restricted overexpression of kinase-dead mammalian target of Rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function
- Rapamycin at subimmunosuppressive levels inhibits mesangial cell proliferation and extracellular matrix production
- Mammalian target of Rapamycin (mTOR) pathway signalling in lymphomas
- Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and Rapamycin combination therapy
- Nucleophosmin mediates mammalian target of Rapamycin–Dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes
- Effects of Rapamycin on cell proliferation and phosphorylation of mTOR and p70S6K in HepG2 and HepG2 cells overexpressing constitutively active Akt/PKB
- Mammalian target of Rapamycin inhibition halts the progression of proteinuria in a rat model of reduced renal mass
- Fatty acid synthase inhibitors modulate energy balance via mammalian target of Rapamycin complex 1 signaling in the central nervous system
- Rapamycin does not improve insulin sensitivity despite elevated mammalian target of Rapamycin complex 1 activity in muscles of ob/ob mice
- inhibition of apoptosis through localized delivery of Rapamycin-loaded nanoparticles prevented neointimal hyperplasia and reendothelialized injured artery
- Epithelial-to-mesenchymal transition of human proximal tubular epithelial cells: effects of Rapamycin, mycophenolate, cyclosporin, azathioprine, and …
- Regulatory effects of mammalian target of Rapamycin-mediated signals in the generation of arsenic trioxide responses
- Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase-and mammalian target of Rapamycin-dependent mechanism
- Non‐human primate fetal kidney transcriptome analysis indicates mammalian target of Rapamycin (mTOR) is a central nutrient‐responsive pathway
- Compared effect of immunosuppressive drugs cyclosporine A and Rapamycin on cholesterol homeostasis key enzymes CYP27A1 and HMG‐CoA reductase
- On the action of cyclosporine A, Rapamycin and tacrolimus on M. avium including subspecies paratuberculosis
- Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of Rapamycin complex 1 (mTORC1)-mediated phosphorylation
- Improved blood compatibility of Rapamycin-eluting stent by incorporating curcumin
- Follicle-stimulating hormone increases tuberin phosphorylation and mammalian target of Rapamycin signaling through an extracellular signal-regulated kinase …
- Monitoring antitumor efficacy of Rapamycin in Kaposi sarcoma
- Phosphatidylinositol 3-kinase-AKT-mammalian target of Rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer
- Rapamycin downregulates the inhibitory receptors ILT2, ILT3, ILT4 on human dendritic cells and yet induces T cell hyporesponsiveness independent of FoxP3 …
- Initial testing (stage 1) of the mTOR inhibitor Rapamycin by the pediatric preclinical testing program
- Insulin‐like growth factor‐1 (IGF‐1) and leucine activate pig myogenic satellite cells through mammalian target of Rapamycin (mTOR) pathway
- Rapamycin impairs β-cell proliferation in vivo
- … acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of Rapamycin …
- Upstream signaling inhibition enhances Rapamycin effect on growth of kidney cancer cells
- Hsf1 activation inhibits Rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysis
- Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in Rapamycin
- The YCR079w gene confers a Rapamycin-resistant function and encodes the sixth type 2C protein phosphatase in Saccharomyces cerevisiae
- Combination of Rapamycin and 17-allylamino-17-demethoxygeldanamycin abrogates Akt activation and potentiates mTOR blockade in breast cancer cells
- … Signaling Pathway Induces Resistance to the Apoptotic Activities of SCH66336 (Lonafarnib) through Akt/Mammalian Target of Rapamycin–Mediated Increases in …
- Antiproliferative effect of Rapamycin on human T-cell leukemia cell line Jurkat by cell cycle arrest and telomerase inhibition
- A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of Rapamycin inhibitor, in patients with relapsed or refractory hematologic …
- Ocular toxicity and distribution of subconjunctival and intravitreal Rapamycin in horses
- Response of U87 glioma xenografts treated with concurrent Rapamycin and fractionated radiotherapy: possible role for thrombosis
- Mammalian target of Rapamycin activation impairs hepatocytic differentiation and targets genes moderating lipid homeostasis and hepatocellular growth
- Regression of pulmonary lymphangioleiomyomatosis (PLAM)-associated retroperitoneal angiomyolipoma post–lung transplantation with Rapamycin treatment
- Regulation of neurogenesis and epidermal growth factor receptor signaling by the insulin receptor/target of Rapamycin pathway in Drosophila
- inhibition of mammalian target of Rapamycin signaling by 2-(morpholin-1-yl) pyrimido [2, 1-α] isoquinolin-4-one
- Further delineation of the continuous human neoplastic enterochromaffin cell line, KRJ-I, and the inhibitory effects of lanreotide and Rapamycin
- Intracellular mechanisms of metabolism regulation: the role of signaling via the mammalian target of Rapamycin pathway and other routes
- Loss of tuberous sclerosis complex-2 function and activation of mammalian target of Rapamycin signaling in endometrial carcinoma
- The mammalian target of Rapamycin pathway and its role in molecular nutrition regulation
- Cotylenin A, a new differentiation inducer, and Rapamycin cooperatively inhibit growth of cancer cells through induction of cyclin G2
- Effects of Rapamycin in liver transplantation.
- Rapamycin inhibits multiple stages of c-Neu/ErbB2–induced tumor progression in a transgenic mouse model of HER2-positive breast cancer
- Rapamycin enriches for CD4+ CD25+ CD27+ Foxp3+ regulatory T cells in ex vivo-expanded CD25-enriched products from healthy donors and patients with …
- Rapamycin down-regulates LDL-receptor expression independently of SREBP-2
- Differential regulation of vascular endothelial growth factor by Akt and mammalian target of Rapamycin inhibitors in cell lines derived from childhood solid tumors
- Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of Rapamycin pathway components
- Effects of Rapamycin on active Heymann nephritis
- Rationale for a phase I trial of erlotinib and the mammalian target of Rapamycin inhibitor everolimus (RAD001) for patients with relapsed non–small cell lung cancer
- Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of Rapamycin through the STAT3-SOCS3 pathway
- Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin module for acute myelogenous leukemia therapy: from bench to bedside
- Rapamycin reduces CCR5 mRNA levels in macaques: potential applications in HIV-1 prevention and treatment
- … and inducible nitric-oxide synthase expression through the integrin/integrin-linked kinase/Akt/mammalian target of Rapamycin pathway in osteoblasts
- Rapamycin reverses NPM-ALK-induced glucocorticoid resistance in lymphoid tumor cells by inhibiting mTOR signaling pathway, enhancing G 1 cell cycle …
- Rapamycin enhances the number of alloantigen-induced human CD103+ CD8+ regulatory T cells in vitro
- GADD34 inhibits mammalian target of Rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress
- Delivery of Rapamycin‐loaded nanoparticle down regulates ICAM‐1 expression and maintains an immunosuppressive profile in human CD34+ progenitor‐derived …
- Four-year clinical follow-up of the Rapamycin-eluting stent evaluated at Rotterdam Cardiology Hospital registry
- Human melanoma cytolysis by combined inhibition of mammalian target of Rapamycin and vascular endothelial growth factor/vascular endothelial growth factor …
- Surgical wound‐healing complications in heart transplant recipients treated with Rapamycin
- Mammalian target of Rapamycin as a target in hematological malignancies
- Does addition of estradiol improve the efficacy of a Rapamycin-eluting stent? Results of the ISAR-PEACE randomized trial
- The effects of Rapamycin in the progression of renal fibrosis
- Mechanism of apoptosis induced by IFN-α in human myeloma cells: role of Jak1 and Bim and potentiation by Rapamycin
- p21-activated kinase 1 is activated through the mammalian target of Rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in …
- Effect of supplemental dietary zinc on the mammalian target of Rapamycin (mTOR) signaling pathway in skeletal muscle and liver from post-absorptive mice
- Combined treatment with triptolide and Rapamycin prolongs graft survival in a mouse model of cardiac transplantation
- Synergistic effect of mTOR inhibitor Rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells
- Rapamycin stimulates arginine influx through CAT2 transporters in human endothelial cells
- Mammalian target of Rapamycin is the key effector of phosphatidylinositol-3-OH–initiated proliferative signals in the thyroid follicular epithelium
- Down-regulation of phosphatidylinositol 3′-kinase/AKT/molecular target of Rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer
- The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of Rapamycin (RAD001) decreases glioma proliferation and invasion
- EMAP-II downregulation contributes to the beneficial effects of Rapamycin after vascular injury
- Rescue of Degradation‐Prone Mutants of the FK506‐Rapamycin Binding (FRB) Protein with Chemical Ligands
- Antiproliferative and overadditive effects of Rapamycin and FTY720 in pancreatic cancer cells in vitro
- Rapamycin for treatment of refractory dysthyroid compressive optic neuropathy
- Randomized trial of Rapamycin-and paclitaxel-eluting stents with identical biodegradable polymeric coating and design
- Nutrient content of diet affects the signaling activity of the insulin/target of Rapamycin/p70 S6 kinase pathway in the African malaria mosquito Anopheles gambiae
- Rapamycin delays growth of Wnt-1 tumors in spite of suppression of host immunity
- Rapamycin together with herceptin significantly increased anti‐tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells
- Short-and long-term effects of cytochalasin D, paclitaxel and Rapamycin on wall thickening in experimental porcine vein grafts
- Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of Rapamycin pathway in Barrett’s-associated esophageal adenocarcinoma
- A phase II study of oral mammalian target of Rapamycin (mTOR) inhibitor, RAD001 (everolimus), in patients with recurrent endometrial carcinoma (EC)
- Rapamycin shows anticancer activity in primary chronic lymphocytic leukemia cells in vitro, as single agent and in drug combination
- External application of Rapamycin-eluting film at anastomotic sites inhibits neointimal hyperplasia in a canine model
- Rapamycin blunts nutrient stimulation of eIF4G, but not PKCε phosphorylation, in skeletal muscle
- ABT-263 and Rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo
- mTOR inhibitors (Rapamycin and its derivatives) and nitrogen containing bisphosphonates: bi-functional compounds for the treatment of bone tumours
- DCO2 on-line measurement used in Rapamycin fed-batch fermentation process
- Identification of the Rapamycin‐sensitive phosphorylation sites within the Ser/Thr‐rich domain of the yeast Npr1 protein kinase
- Golgi Manganese Transport Is Required for Rapamycin Signaling in Saccharomyces cerevisiae
- How to control lymphangiogenesis: A novel role for Rapamycin
- Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of Rapamycin
- Components of the Vid30c are needed for the Rapamycin-induced degradation of the high-affinity hexose transporter Hxt7p in Saccharomyces cerevisiae
- An approach to analyse the specific impact of Rapamycin on mRNA-ribosome association
- Ex vivo Rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection
- Rapamycin-regulated control of antiangiogenic tumor therapy following rAAV-mediated gene transfer
- Rapamycin prevents mesenteric neo‐angiogenesis and reduces splanchnic blood flow in portal hypertensive mice
- Upregulation of tissue factor expression and thrombogenic activity in human aortic smooth muscle cells by irradiation, Rapamycin and paclitaxel
- Chylous ascites in a renal transplant recipient under sirolimus (Rapamycin) treatment
- Combination antifungal therapy involving amphotericin B, Rapamycin and 5-fluorocytosine using PEG-phospholipid micelles
- Serotonin Induces Memory-Like, Rapamycin-Sensitive Hyperexcitability in Sensory Axons of Aplysia That Contributes to Injury Responses
- Activation of the mammalian target of Rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bɛ mRNA translation and protein …
- Human herpesvirus‐8 (HHV‐8)‐associated primary effusion lymphoma in two renal transplant recipients receiving Rapamycin
- An RNA Interference Screen Identifies a Novel Regulator of Target of Rapamycin That Mediates Hypoxia Suppression of Translation in Drosophila S2 Cells
- Identification of AUF1 as a Rapamycin-responsive binding protein to the 5′-terminal oligopyrimidine element of mRNAs
- Mitogen-stimulated and Rapamycin-sensitive glucose transporter 12 targeting and functional glucose transport in renal epithelial cells
- Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, Rapamycin and Bcl-2 inhibitor GX15-070
- Modulation of the activities of AMP‐activated protein kinase, protein kinase B, and mammalian target of Rapamycin by limiting energy availability with 2‐deoxyglucose
- PTEN and Rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway
- Role of adenosine 5′-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of Rapamycin signaling
- Pharmacokinetics of sirolimus (Rapamycin) in subjects with severe hepatic impairment
- … Preconditioning Decreases Myocardial Infarction in Rabbits via Up-regulation of Hypoxia Inducible Factor 1 That Is Mediated by Mammalian Target of Rapamycin
- Stress and IGF-I differentially control cell fate through mammalian target of Rapamycin (mTOR) and retinoblastoma protein (pRB)
- … of the neuronal monocarboxylate transporter MCT2 by translational activation via stimulation of the phosphoinositide 3‐kinase–Akt–mammalian target of Rapamycin …
- Possible involvement of persistent activity of the mammalian target of Rapamycin pathway in the cisplatin resistance of AFP-producing gastric cancer cells
- Cyclin B synthesis and Rapamycin‐sensitive regulation of protein synthesis during starfish oocyte meiotic divisions
- Comparison of a polymer‐free Rapamycin‐eluting stent (YUKON) with a polymer‐based paclitaxel‐eluting stent (TAXUS) in real‐world coronary artery lesions
- The Rheb switch 2 segment is critical for signaling to target of Rapamycin complex 1
- Cyclosporine A and Rapamycin induce in vitro cholesteryl ester transfer protein activity, and suppress lipoprotein lipase activity in human plasma
- Rapamycin reduces CCR5 density levels on CD4 T cells, and this effect results in potentiation of enfuvirtide (T-20) against R5 strains of human immunodeficiency …
- Three‐year clinical outcomes after coronary stenting of chronic total occlusion using sirolimus‐eluting stents: Insights from the Rapamycin‐eluting stent evaluated at …
- Chronic alcohol consumption alters mammalian target of Rapamycin (mTOR), reduces ribosomal p70s6 kinase and p4E-BP1 levels in mouse cerebral cortex
- Intrinsically lower AKT, mammalian target of Rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia …
- … preclinical studies: timing of treatment, combination of a Rapamycin analog (CCI-779) and interferon-gamma, and comparison of Rapamycin to CCI-779
- Rapamycin limits formation of active eukaryotic initiation factor 4F complex following meal feeding in rat hearts
- CD8+ T‐Cell Depletion and Rapamycin Synergize with Combined Coreceptor/Stimulation Blockade to Induce Robust Limb Allograft Tolerance in Mice
- Antineoplastic effect of Rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts
- Mammalian target of Rapamycin pathway inhibition enhances the effects of 5-aza-dC on suppressing cell proliferation in human gastric cancer cell lines
- The Cairo kidney center protocol for Rapamycin-based sequential immunosuppression in kidney transplant recipients: 2-year outcomes
- … of insulin-like growth factor binding protein-2 by MCF-7 breast cancer cells is regulated through the phosphatidylinositol 3-kinase/AKT/mammalian target of Rapamycin …
- Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and Rapamycin
- IGF-I receptor inhibition combined with Rapamycin or temsirolimus inhibits neuroblastoma cell growth
- Chronic allograft dysfunction: can we use mammalian target of Rapamycin inhibitors to replace calcineurin inhibitors to preserve graft function?
- The mammalian target of Rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5′-untranslated region in the …
- Rapamycin enhances the anti-tumor effect of gemcitabine in pancreatic cancer cells.
- Renal cortex neuronal nitric oxide synthase in response to Rapamycin in kidney transplantation
- The MAP kinase-activated protein kinase Rck2p plays a role in Rapamycin sensitivity in Saccharomyces cerevisiae and Candida albicans
- … Factor‐1 and Transforming Growth Factor‐β Controls the Quiescence/Cycling Switch of CD34+ Progenitors Through FoxO3 and Mammalian Target of Rapamycin
- The effect of Rapamycin on DNA synthesis in multiple tissues from late gestation fetal and postnatal rats
- Rapamycin reverses TLR4 signaling-triggered tumor apoptosis resistance by disrupting Akt-mediated Bcl-xL upregulation
- Reversal of tacrolimus‐related hypertrophic cardiomyopathy after conversion to Rapamycin in a pediatric liver transplant recipient
- Mechanisms of mammalian target of Rapamycin inhibition in sarcoma: present and future
- siRNA targeting mammalian target of Rapamycin (mTOR) attenuates experimental proliferative vitreoretinopathy
- Synthesis, characterization and antiproliferative activity of Rapamycin-loaded poly (N-isopropylacrylamide)-based nanogels in vascular smooth muscle cells
- Prolongation of cardiac allograft survival by Rapamycin and the invariant natural killer T cell glycolipid agonist OCH
- Rapamycin Inhibits Growth Factor-Induced Cell Cycle Regulation in Pancreatic β Cells
- Molecular impacts of Rapamycin-based drug combinations: combining Rapamycin with gemcitabine or imatinib mesylate (Gleevec) in a human leiomyosarcoma model
- Rapamycin-induced cytotoxic signal transduction pathway
- Effect of rifampicin to inhibit Rapamycin-induced autophagy via the suppression of protein phosphatase 2A activity
- Specific mTOR inhibitor Rapamycin enhances cytotoxicity induced by alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea …
- Requirements of phosphatidylinositol-3 kinase and mammalian target of Rapamycin for estrogen-induced proliferation in uterine leiomyoma-and myometrium-derived …
- Mass balance in Rapamycin autoxidation
- Targeting the mammalian target of Rapamycin in myxoid chondrosarcoma
- Acetaldehyde promotes Rapamycin-dependent activation of p70S6K and glucose uptake despite inhibition of Akt and mTOR in dopaminergic SH-SY5Y human …
- Conversion to Rapamycin immunosuppression for malignancy after kidney transplantation
- Normal phase and reverse phase HPLC-UV-MS analysis of process impurities for Rapamycin analog ABT-578: Application to active pharmaceutical ingredient process …
- Non-Conventional method for evaluation and optimization of medium components for Rapamycin production by Streptomyces hygroscopicus
- Administration of triiodo-L-thyronine into dorsal hippocampus alters phosphorylation of Akt, mammalian target of Rapamycin, p70S6 kinase and 4E-BP1 in rats
- Possible mechanism by which Rapamycin increases cyclosporine nephrotoxicity
- … Extracellular Signal-regulated Kinase 1/2 and c-Jun NH2-Terminal Kinase Downstream of Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin
- Adverse effects of mammalian target of Rapamycin inhibitors during the postoperative period after cardiac transplantation
- ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with Rapamycin is effective for subcutaneous hepatocellular carcinoma xenograft
- Neointimal expression of Rapamycin receptor FK506-binding protein FKBP12: postinjury animal and human in-stent restenosis tissue characteristics
- Successful treatment of post-renal transplant gastric and pulmonary Kaposi’s sarcoma with conversion to Rapamycin treatment
- A comparison of clinical and angiographic outcomes after Excel bioabsorbable polymer versus Firebird durable polymer Rapamycin-eluting stent for the treatment of …
- Effect of Rapamycin on hepatocyte function and proliferation induced by growth factors
- Lentiviral vectors mediate nonimmunosuppressive Rapamycin analog-induced production of secreted therapeutic factors in the brain: regulation at the level of …
- Rapamycin bypasses vesicle-mediated signaling events to activate Gln3 in Saccharomyces cerevisiae
- Nanoparticle albumin-bound (nab) Rapamycin as an anticancer agent
- Rapamycin conditionally inhibits Hsp90 but not Hsp70 mRNA translation in Drosophila: implications for the mechanisms of Hsp mRNA translation
- Differential modulation of mitogen driven proliferation and homeostasis driven proliferation of T cells by Rapamycin, Ly294002 and chlorophyllin
- A phase 1b study of oral Rapamycin (sirolimus) in patients with advanced malignancies
- Rapamycin-loaded poly (lactic-co-glycolic) acid nanoparticles for intraarterial local drug delivery: preparation, characterization, and in vitro/in vivo release
- A Combination of Donor Specific Transfusion and Rapamycin Prolonges Cardiac Allograft Survival in Mice
- Immunoassay determination of Rapamycin: reliability of the method with respect to liquid chromatography mass spectrometric quantification
- Thrombin induces osteoprotegerin synthesis via phosphatidylinositol 3′‐kinase/mammalian target of Rapamycin pathway in human periodontal ligament cells
- Galectin-1 upregulates glucose transporter-1 expression level via protein kinase C, phosphoinositol-3 kinase, and mammalian target of Rapamycin pathways in mouse …
- inhibition of the mammalian target of Rapamycin (mTOR) in a case of refractory primary cutaneous anaplastic large cell lymphoma
- Magic with Rapamycin
- Rapamycin promotes emergence of IL-10-secreting donor lymphocyte infusion-derived T cells without compromising their graft-versus-leukemia reactivity
- Rapamycin and cyclosporine have different effects on expression of Ang-1 and Ang-2 and Tie2 in rat renal allograft with chronic allograft nephropathy
- Phorbol 12-myristate 13-acetate and serum synergize to promote Rapamycin-insensitive cell proliferation via protein kinase C-eta
- A recent application of fluoro-18-deoxyglucose positron emission tomography, treatment monitoring with a mammalian target of Rapamycin inhibitor: an example …
- Orally administered Rapamycin, dacarbazine or both for treatment of human melanoma evaluated in severe combined immunodeficiency mice
- … /p70S6K signaling pathway constitutively activated in esophageal squamous cell carcinona cell lines and inhibition of the pathway by Rapamycin and siRNA against …
- Anti-CD25 mAb, anti-IL2 mAb, and IL2 block tolerance induction through anti-CD154 mAb and Rapamycin in xenogeneic islet transplantation
- Effect of chemotherapy with cisplatin and Rapamycin against Hep-2 cells in vitro
- A new trick for an old drug: mTOR inhibitor Rapamycin augments the effect of fluorouracil on hepatocellular carcinoma by inducing cell senescence
- Loss of phosphatase and tensin homologue deleted on chromosome 10 and phosphorylation of mammalian target of Rapamycin are associated with progesterone …
- … MCF-7 breast cancer tumors are associated with hyperactivation of the mTOR pathway: therapeutic implications for combination therapy with Rapamycin
- Rapamycin, Mycophenolate Mofetil, Methylprednisolone, and Cytotoxic T-Lymphocyte–Associated Antigen 4 Immunoglobulin–Based Conditioning Regimen to Induce …
- Long-term effects of Rapamycin treatment on insulin mediated phosphorylation of Akt/PKB and glycogen synthase activity
- A fast and simple method to prepare the FKBP-Rapamycin binding domain of human target of Rapamycin for NMR binding assays
- Dentritic cell derived IL-18 production is inhibited by Rapamycin and sanglifehrin A, but not cyclosporine A
- Hypoxia-induced hypomyelination in the developing brain is mammalian target of Rapamycin-4E-binding protein-1 signaling dependent
- Combination of Nab-Rapamycin and Perifosine Induces Synergistic Cytotoxicity and Antitumor Activity Via Autophagy and Apoptosis in Multiple Myeloma (MM)
- Effects of mTOR inhibitor Rapamycin on Smad 3 protein and collagen type I expression in rat myocardial fibroblasts infected with coxsackie virus B 3
- Synergistic effect of Rapamycin (RPM) and PD98059 on cell cycle and mTOR signal transduction in human colorectal cancer cells
- A phase II study of mammalian target of Rapamycin (mTOR) inhibitor RAD001 plus imatinib mesylate (IM) in patients with previously treated advanced renal carcinoma …
- Influence of Rapamycin on rat macrophage viability and chemotaxis toward allogenic pancreatic islet supernates
- Orally administered Rapamycin does not modify rat aortic vascular tone
- Rapamycin inhibits the growth of cholangiocarcinoma cells in vitro
- Sirolimus (Rapamycin) induced proteinuria in a patient undergoing allogeneic hematopoietic stem cell transplant
- Induction effect of Rapamycin combined paclitaxel on apoptosis of ovarian cancer cell lines A2780 and SKOV3 and the molecular mechanism
- Temozolomide combined with the PI3K inhibitor LY294002 or the mTOR inhibitor Rapamycin inhibits melanoma cell growth, survival and invasion
- Negative inotropic effect of Rapamycin on isolated human cardiomyocytes
- PDE4B Activity Controls Glucorticoid and Rapamycin Effects in DLBCL.
- Effects of Rapamycin on intracellular cholesterol homeostasis of glomerular mesangial cell in the presence of interleukin-1β
- TOR (target of Rapamycin) as an anti-cancer target
- The expression of mammalian target of Rapamycin in Ishikawa and HEC-1A cells
- Cancer and transplantation intersect at the mammalian target of Rapamycin
- Expression of connective tissue growth factor in renal interstitial fibrosis after ureteral obstruction and effects of Rapamycin thereupon: experiment with rats
- Rapamycin induces Balb/c murine CD4^+ CD25^+ foxp3^+ T cells proliferations
- Mannan and peptidoglycan induce COX‐2 protein in human PMN via the mammalian target of Rapamycin
- Establishment of a Conjugation System for the Rapamycin Producer Streptomyces hygroscopicus NRRL5491 [J]
- Effeet of Rapamycin on mTOR and eIF-4E expression in coxsackievirus B3-induced rat myocardial cells [J]
- Effects of Rapamycin on human hepatocellular carcinoma xenografts in nude mice [J]
- Induction of PPAR gamma signaling and autophagy as a mechanism mediating acquired Rapamycin resistance in breast cancer models
- A drug interaction study of sorafenib (S) and Rapamycin (R) in patients with advanced malignancies
- Regression of Pulmonary Lymphangioleiomyomatosis (PLAM)-Associated Retroperitoneal Angiomyolipoma Post–Lung Transplantation With Rapamycin Treatment
- Initial use of Rapamycin after kidney transplantation
- Combination of CP-751871, a human monoclonal antibody against the IGF-1 receptor, with Rapamycin results in a highly effective therapy for xenografts derived from …
- Rapamycin controls multiple signalling pathways involved in cancer cell survival
- Phosphatidylinositol 3-kinase/mammalian target of Rapamycin pathway is critical for survival and proliferation of pancreatic cancer stem-like side population cells
- Long-term limb allograft survival using a short course of anti-CD45RB monoclonal antibody, LF 15-0195, and Rapamycin in a mouse model
- Resveratrol-and Rapamycin-induced Morphological Changes to Human Epithelial Colon Cancer DLD-1 Cells
- Phosphoinositide 3-kinase (PI3K) and nutrient sensing mTOR (mammalian target of Rapamycin) pathways control T lymphocyte trafficking
- Does the use of paclitaxel or Rapamycin-eluting stent decrease further need for coronary-artery bypass grafting when compared with bare-metal stent?
- Preclinical rationale for combination targeted therapy in advanced clear cell renal cell carcinoma (RCC): Abrogation of Rapamycin-mediated induction of AKT …
- Effect of Rapamycin on CD4 (+) CD25 (+) regulatory T cells in allo-transplantation tolerance model
- Effects of constant magnetic fields on proliferation and migration of endothelial progenitor cells under Rapamycin intervention: experiment with rats
- Effect of Rapamycin on expression of origin recognition complex 1 mRNA in vascular smooth muscle cells [J]
- The different effects of cyclosporin A and Rapamycin on regulatory CD4+CD25+ T cells: potential relationship with transplant tolerance induction
- Experimental study of stent-based delivery of Rapamycin and tirofiban on preventing in-stent thrombosis and restenosis [J]
- The clinical contrast investigation of Rapamycin eluting stent between domestic-made and imported [J]
- Perivascular delivery of Rapamycin in pluronic gel inhibits neointimal hyperplasia in a rat carotid artery injury model, and the complementary role of carotid …
- Effect of Rapamycin on the cell cycle arrest of T lymphocytes
- mTOR kinase inhibitors exhibit properties that distinguish them from Rapamycin
- … insulin-like growth factor-1 receptor (IGF-1R), enhances the anti-tumor activities of Tarceva in non-small cell lung carcinoma (NSCLC) and Rapamycin in sarcoma cell …
- Conversion to Rapamycin in a renal transplant patient with von Hippel-Lindau disease: encouraging results—a case report
- Rapamycin to the rescue!
- Changes in FDG-PET in response to Rapamycin (R) correlated with Akt pathway inhibition and not with clinical outcome
- Rapamycin inhibits proliferation of cells from TSC skin tumors.
- Expression of mammalian target of Rapamycin and p70 S6 kinase in rabbit periodontal tissues remodeling during orthodontic tooth movement
- Glucose transporter 12 and mammalian target of Rapamycin complex 1 signaling: a new target for diabetes-induced renal injury?
- Clinical Application of Mammalian Target of Rapamycin Inhibitor in Kidney Transplantation
- SYNERGISTIC EFFECT OF CYCLOSPORINE IN Rapamycin-INDUCE DIABETIC DISEASE: 1937
- In Vitro Release of Rapamycin Sustained Eluting Stent Detected by a New Designed Circulating Device
- Cause analysis and treatment of Rapamycin-eluting stent thrombosis [J]
- Elevated phosphorylated mammalian target of Rapamycin (p-mTOR) expression in human neoplasms
- Comparison between the Inhibitory and Cytotoxic Effects of Rapamycin and Paclitaxel on Endothelial Cell Proliferation
- Treatment with sodium butyrate and Rapamycin inhibit growth of human cervical cancer cells
- Pediatric Preclinical Testing Program (PPTP) evaluation of the mTOR inhibitor Rapamycin
- The application of Rapamycin drug-eluting stents in elderly patients with acute myocardial infarction [J]
- Effect of mammalian target of Rapamycin inhibitors on neuroblastoma MYCN expression and tumor growth
- Efficacy and Safety Study of Rapamycin in Treating Mesangial Proliferative Glomerulonephritis: Analysis of 11 Cases
- Effect of Orthodontics on Mammalian Target of Rapamycin and p70 S6 Kinase in Rabbit Periodontal Tissues [J]
- Rapamycin affects eIF-4E expression in rat myocardial fibroblasts infected by Coxsackievirus B3
- Local applied Rapamycin inhibits intimal hyperplasia in vein graft after CABG
- Human monoclonal antibody CP751871, combined with Rapamycin is effective treatment for childhood sarcoma xenografts
- P1-084: Mammalian target of Rapamycin (mTOR) inhibition by RAD001 in patients (pts) with reccurent non-small cell lung cancer (NSCLC): Use of 18F …
- The application of Rapamycin drug-eluting stents in elderly patients with coronary heart disease [J]
- Progress of Rapamycin in hepatocellular carcinoma
- Predicting Rapamycin response using pathway profile in a population of genetically engineered hHer2 driven breast tumor model
- Effect of conversion from calcineurin inhibitors to Rapamycin on chronic allograft nephropathy
- The mTOR inhibitor Rapamycin demonstrates activity against AML in combination with imatinib mesylate and with 5-azacytidine.
- Effeet of Rapamycin on mTOR and eIF-4E expression in coxsackievirus B3-induced rat myocardial cells
- Combined regimen of Rapamycin and ciclosporin in long-term follow-up in renal allograft recipients
- Rapamycin modulates the maturation of rat bone marrow-derived dendritic cells
- Experimental study on Rapamycin-batroxobin eluting stent and its prevention of coronary restenosis after angiophaty [J]
- Cellular differentiation of Rapamycin, PI3 kinase and TOR kinase inhibitors
- Histone deacetylase inhibition with LBH589 inhibits the Rapamycin insensitive Rictor-mTOR (mTORC2) complex and translation initiation factor eIF4E activation in …
- 9B-6 inhibition of Smooth Muscle Proliferation by Ultrasound-Triggered Release of Rapamycin from Microbubbles
- Combination of the VEGF receptor tyrosine kinase sunitinib and the mTOR inhibitor Rapamycin leads to tumor regression in the RENCA model
- Toxicology and safety pharmacology of nanoparticle albumin-bound (nab) Rapamycin (ABI-009)
- Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis.
- Expression and secretion of VEGF in solid tumor cells is mediated by the mammalian target of Rapamycin (mTOR)
- The design and pharmacokinetics in vivo of Rapamycin-PLGA membrane eluting stent [J]
- Rapamycin combined with donor bone marrow-derived immature dendritic cells induces mouse skin allograft tolerance
- Anti-Proliferative Effect of Rapamycin on Human T Cell Leukemia Cell Line Jurkat by Cell Cycle Arrest and Telomerase inhibition.
- Phase I study of gefitinib and Rapamycin in adult patients with recurrent glioblastoma multiforme (GBM)
- Rapamycin-induced inhibition of HTLV-I LTR activity is rescued by c-Myb
- Effect of RNA interference targeting mammalian target of Rapamycin on the proliferation of vascular smooth muscle cell and the intimal hyperplasia
- Anti-Cancer Effects of Rapamycin on U937 Cell Line.
- Comparison of inflammatory markers and angiographic outcomes after implantation of Rapamycin and paclitaxel-eluting stents
- The roles of mammalian target of Rapamycin (mTOR) and p21 in the autophagy pathway after DNA mismatch repair processing of 6-thioguanine
- Molecular determinants of sensitivity to Rapamycin in NSCLC
- Dasatinib and Rapamycin synergistically inhibit the proliferation of cells expressing oncogenic KIT kinase via global inhibition of AKT-dependent signaling
- Anti-angiogenic activity of Rapamycin in Rapamycin-sensitive and-resistant tumor xenograft models
- Mammalian target of Rapamycin impairs insulin’s ability to promote protein kinase B phosphorylation in isolated rat skeletal muscle
- Dual Effects of Rapamycin on Immuno-suppression and Tumor inhibition
- Rapamycin Inhibits Proliferation of Human Lung Cancer Cell Lines [J]
- Combination therapy with Rapamycin and atorvastatin
- PI-103, a Dual Inhibitor of Class IA Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin, Has Cytotoxic Activity in T-Cell Acute Lymphoblastic …
- The effects of Rapamycin on body weight and insulin resistance in KKAy mice
- Cell Proliferation in Multiple Rat Tissues In Vivo is Rapamycin Resistant
- The Effect of Rapamycin on Repair of Liver Ischemia/Reperfusion Injury
- Genetically engineered murine tumor models for drug response prediction: population based pathway profiles predict response to Rapamycin in a HER2 driven breast …
- The effect of Rapamycin on PSA kinetics in men without prostate cancer
- Chronic exposure to Rapamycin induces endothelial dysfunction in vitro
- Antiproliferative effects of mTOR inhibition with Rapamycin (RAP) either given as a single agent or in combination with carboplatin and paclitaxel in Human Head and …
- P158-M Expression of c-kit, p-mTOR and p-NFKappaB in angiolymphoid hyperplasia with eosinophilia: Potential for therapy with imitanib mesylate, Rapamycin and …
- Use of Rapamycin to inhibit VEGF for the treatment of primary effusion lymphoma
- Rapamycin and CCI-779 suppress the growth of hepatocellular carcinoma cells
- Combined effects of Rapamycin and bicalutamide in androgen-dependent and-independent prostate cancer cells
- Cholangiocarcinoma cells are selectively susceptible to Rapamycin treatment
- The Mammalian Target of Rapamycin and Multiple Myeloma
- Rapamycin modulates the eNOS versus shear stress relationship
- Effect of Rapamycin on the Proliferation and Apoptosis of Human Leukemia Cell Line HL-60 [J]
- EFFECTS OF Rapamycin COMBINED IMMUNOSUPPRESSION ON RENAL FUNCTION AFTER LIVER TRANSPLANTATION
- Effects of Rapamycin on proliferation, function and cell-cycle of mouse T lymphocytes in vitro
- Mammalian target of Rapamycin and leukemia treatment
- Clinical utility of combined administration of Rapamycin and low dose of cyciosporin a in kidney transplantation recipients
- Rapamycin Induced Transactivation of EGFR: Implications in the Regulation of Cellular Apoptosis
- The mammalian target of Rapamycin (mTOR). Foreword.
- Mammalian Target of Rapamycin Activation Impairs
- Clinical application of Rapamycin-eluting stent in coronary artery disease
- Differential response of mTORC1 and mTORC2 to Rapamycin in Rapamycin-sensitive and-resistant tumor xenograft models
- Effect of IGF‐I and Rapamycin on diaphragm muscle atrogenes with malnutrition
- Functional genomic identification and validation of Rapamycin response genes using high throughput RNA interference
- Rapamycin increases sensitivity to cisplatin in mesothelioma cell lines
- Rapamycin inhibition of cell motility is associated with its suppression of synthesis of GTPases
- Yeast as a Model to Study the Immunosuppressive and Chemotherapeutic Drug Rapamycin
- MANAGEMENT AND LONG-TERM OUTCOMES OF WOUND-HEALING COMPLICATIONS ASSOCIATED WITH Rapamycin: 1108
- Rapamycin Augments Akt Activation in In Vitro and In Vivo Models of Cardiac Hypertrophy
- The study of anti-proliferation effect of Rapamycin on human breast cancer MCF-7 cells under hypoxia [J]
- Rapamycin Reduces CCR5 Density Levels
- Rapamycin inhibits Stearoyl-CoA Desaturase 1 expression in breast cancer cell lines.
- Overexpression analysis reveals novel growth regulators in the target of Rapamycin signaling pathway
- Nutrient Stimulation of eIF4G Phosphorylation, but not PKC is Rapamycin Sensitive in Skeletal Muscle
- Role of Rapamycin on cultured human Tenon′ s capsule fibroblasts
- Statins and Rapamycin act synergistically to enhance vascular endothelial cytoprotection
- Antitumor activity of Rapamycin and octreotide as single agents or in combination in neuroendocrine tumors
- Acute Rapamycin Treatment Does Not Improve In Vivo Insulin Action in Ob/Ob or High Fat Fed Mice
- Administration of Rapamycin in vivo and in vitro prolonged allograft survival associated with iTregs
- THE EFFECT OF LIVER REGENERATION ON Rapamycin PHARMACOKINETICS: 1226
- The Clinical Application of Rapamycin Eluting Stent in Elderly Patients with Coronary Heart Disease.
- Rapamycin induced “stunning” on FDG PET/CT in pancreatic cancer
- Protective Effect of Pretreated Rapamycin on Renal Ischemia-Reperfusion Injury in Rats
- Rapamycin impairs skin γδ T cell function resulting in autophagy
- Rapamycin aggravates the renal damage in rats with protein overload nephropathy and the protection of losartan
- Observation in Safety and Short-term Efficacy of Domestic-made Rapamycin-eluting Stent
- Rapamycin Treatment Exacerbates Nutrition-Induced Diabetes in Psammomys obesus.
- Rapamycin‐sensitive inhibition of Id1 and p21 in C2C12 myoblasts
- Effects of Rapamycin on the Liver Regeneration after Partial Hepatectomy in Rats
- Statin therapy, alone or in combination with Rapamycin, does not reverse Monocotaline Pulmonary Arterial Hypertension
- Comparative study on clinical outcomes of two kinds of Chinese Rapamycin-eluting stent in patients with coronary artery disease
- Rapamycin rescues lactacystin-induced dopaminergic neuron injury in vivo
- Modulation of cell cycle progression by combined Rapamycin-octreotide treatment in pituitary tumor cells
- Local application of Rapamycin inhibits neointimal hyperplasia in experimental vein grafts
- Histologic Changes After Intravitreal Injection of Rapamycin and Bevacizumab in a Porcine Model
- Bevacizumab and Rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
- Study on the activation of mammalian target of Rapamycin in two endometrial carcinoma cells
- Study on the changes of mammalian target of Rapamycin with aging in rat kidneys
- 290: Rapamycin-generated Th2 cell therapy of established acute murine GVHD requires Th2 cell secretion of both IL-4 and IL-10
- Rapamycin CAN AMELIORATE CAN IN RAT ALLOGRAFTS BY AFFECTING RHO/ROCK SIGNAL PATHWAY: 2147
- Clinical study on major adverse cardiac events (MACE) rate in patients implanted with Rapamycin-eluting stents [J]
- Preclinical evaluation of sorafenib in combination with Rapamycin for the treatment of acute myeloid leukemia (AML)
- The Development and Molecular Expression in Mammalian Cells of an HA-Tagged Plasmid Encoding for the Target Of Rapamycin (mTOR)
- The Role of Mammalian Target of Rapamycin (mTOR) Inhibitors in the Treatment of Solid Tumors
- INFLUENCE OF Rapamycin ON RENAL TUBULAR FUNCTION IN RATS WITH OR WITHOUT CYCLOSPORINE TREATMENT: 1938
- Drug eluting stents: long term results in clinical practice. Comparison between Rapamycin and paclitaxel eluting stents
- Nucleophosmin Mediates Mammalian Target of Rapamycin
- Rapamycin inhibits activation of Stat3 in kidney tissue of IgA nephropathy rats
- Leukemia Induced by Altered TRK-Signaling Is Sensitive to Rapamycin Treatment in a Preclinical Model
- Mechanisms of urokinase mediated activation of the mammalian target of Rapamycin (mTOR)
- UROKINASE‐INDUCED SMOOTH MUSCLE CELL MIGRATION INVOLVES THE MAMMALIAN TARGET OF Rapamycin
- Anti-inflammatory properties of Rapamycin on leukocyte-endothelial cell interactions following profound hypoperfusion
- Contrasting effects of Cyclosporine and Rapamycin in de novo generation of alloantigen-specific regulatory T cells (88.45)
- Combination treatment of Rapamycin and low dose irradiation causes cell death in human cancer cells cultured as 3-D spheroids
- Rapamycin effects on mTOR signaling in the MCF10AT series of human breast epithelial cells: a model for proliferative breast disease and carcinoma
- Anti-inflammatory drugs, sirolimus, and inhibition of target of Rapamycin and its effect on vascular diseases
- Effect of Rapamycin in inducing naïve murine effector T cell convert to regulatory T cell
- A high throughput assay for mammalian target of Rapamycin (mTOR) kinase activity
- Rapamycin INDUCES AUTOPHAGY IN ISLETS: RELEVANCE FOR ISLETS TRANSPLANTATION: 556
- Angioplasty stenting with Sirolimus (Rapamycin) eluting stents in type 2 diabetic patients
- The Immunosuppressive drugs Rapamycin and FK506 decrease vasodilation by increasing PKCbetai‐mediated phosphorylation of eNOS Thr495
- Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A driven angiogenesis in part through the blockade of S6Kinase
- Combined Rapamycin-octreotide treatment exerts its superior antiproliferative action by dramatically increasing p27/Kip1 expression
- Characterisation of a novel and highly selective kinase inhibitor of the mammalian target of Rapamycin (mTOR)
- ST2L upregulation promotes maturation resistance in Rapamycin‐conditioned dendritic cells
- P286: Mechanisms of urokinase mediated activation of the mammalian target of Rapamycin (mTOR)
- Akt phosphorylates and negatively regulates hnRNPA1-mediated control of cyclin D1 and c-myc translation in response to Rapamycin
- Intravitreal Rapamycin and Bevacizumab Inhibits VEGF Expression in a Swine Model of Neovascularization
- Acute activation of the mammalian target of Rapamycin complex 1 does not impair in vivo insulin action in mice
- Combined Therapeutic Effects of Vinblastine and Rapamycin on Human Neuroblastoma Growth, Apoptosis, and Angiogenesis
- Cell cycle proteins and hTERT telomerase mRNA expression are independent targets of Rapamycin in ovarian cancer cell lines
- Re-evaluating the roles of proposed modulators of mammalian target of Rapamycin complex 1 (mTORC1) signaling
- P39. Rapamycin and the downstream target of mTOR, ribosomal protein L29 (RPL29), regulate prostate cancer cell growth and bone metastatic potential
- Thymidine phosphorylase-related migratory effect of cancer cell is abrogated by m-TOR inhibitor Rapamycin
- Curcumin inhibition of the mammalian target of Rapamycin signaling pathway
- Synergistic combinations of a novel PI3 Kinase inhibitor with Erlotinib and Rapamycin and the associated effects on downstream signalling
- Evaluation of the mTOT inhibitor, Rapamycin in dogs with spontaneously derived osteosarcoma: A focus on preclinical pharmacokinetics and pharmacodynamics
- Activation of Mammalian Target of Rapamycin (mTOR) in Esophageal Squamous Cell Carcinona Cell Line [J]
- The mammalian target of Rapamycin (mTOR) signaling in thymic lymphomagenesis in Atm-/-mice
- Rapamycin-induced remission of Kaposi’s sarcoma is not associated with expansion of cytotoxic T-lymphocyte subsets
- The Mammalian Target of Rapamycin Plays a Critical Role in the Development of Cardiac Hypertrophy in Spontaneously Hypertensive Rats
- Inhibitory effect of Rapamycin and dexamethasone on production of IL-17 and IFN-c in Vogt–Koyanagi–Harada patients
- Targeted therapy for osteosarcoma using 17AAG and Rapamycin: Identification of new targets by gene microarray profiling and miRNA
- Divergent Roles of PI3K and Akt in Rapamycin-induced Cardioprotection against Ischemia-Reperfusion Injury
- The Combination of the mTOR Inhibitor Rapamycin and Protein Kinase C Inhibitors Produces Marked Synergistic Anti-Myeloma Effects.
- Expansion of Functional Polyclonal Human T-regulatory Cell Lines Using Artificial Antigen Presenting Cells and Rapamycin.(B159)
- Sepsis associated platelet dysfunction & Rapamycin sensitive pathway of lipopolysaccharide signaling
- COMPARISON OF Rapamycin VS. FK506 ON EXPRESSION OF CYTOPROTECTIVE GENES IN THE RAT-KIDNEY ALLOGRAFTS UNDERGOING CHRONIC …
- Synergistic effect of Rapamycin and Casodex in inhibition of cell growth and survival as well as AR transcriptional activity in androgen dependent and independent …
- Clenbuterol antagonizes Rapamycin-induced atrophy in rat soleus muscle
- Ocular Toxicity and Distribution of Intravitreal and Subconjunctival Rapamycin in Horses
- Rapamycin Withdrawal versus Delayed Initiation: Thrombosis vs. Suppression of Neointimal Hyperplasia after Vascular Injury
- Rapamycin prevents cadmium-induced neuronal apoptosis by suppression of MAPK and mTOR pathways
- Changes in gene expression profile after Rapamycin treatment of ErbB2-positive/ErbB2-negative breast carcinoma in organ culture
- Dual inhibition of the Akt pathway by Rapamycin and Perifosine induces synergistic anti-tumor activity in multiple myeloma
- Clinical Benefits of Rapamycin-Eluting Stent Made in China Appliance and Investigation in Patients with Acute Coronary Syndromes
- Rapamycin Causes Reversible Cell Cycle Slowing, Rather Than Cell Cycle Arrest, in Myeloid and Lymphoid Cell Lines and in Acute Leukemia Cells
- Effective inhibition of tumor growth in patient-derived xenografts of hepatocellular carcinoma by Rapamycin and bevacizumab
- Protein kinase C (μ, θ, ϵ)-dependent Bad phosphorylation is an important signaling pathway in IGF-I rescue of sarcoma cells from Rapamycin-induced apoptosis
- Enzastaurin inhibits growth of head and neck cancer cells and xenografts and synergizes with Rapamycin
- Binding of novel Rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
- Combination of somatostatin analogues with Rapamycin analogues as a potential pharmaceutical treatment for non-functioning pituitary adenomas
- Mammalian Target of Rapamycin (mTOR) is Essential for Murine Heart Development
- A spontaneous pancreatic tumor model for monitoring pancreatic lesion and response to Rapamycin treatment through bioluminescence imaging
- Targeted therapy for osteosarcoma using 17AAG and Rapamycin: Identification of new targets using Gene Microarray profiling and MiRNA
- Rapamycin regulates synthesis of transforming growth factor-beta1 and extracellular matrix in arterial neointimal smooth muscle cells
- Utilization of Meso Scale Discovery ELISA technology to quantitate the in vivo pharmacodynamic effects of Rapamycin treatment on the AKT pathway
- Rapamycin blocks leucine‐induced protein synthesis by suppressing mTORC1 activation in skeletal muscle of neonatal pigs
- Rapamycin IS LESS FIBROGENIC THAN FK506 IN RAT MODEL OF CHRONIC ALLOGRAFT NEPHROPATHY: 2144
- Identification and characterization of novel positive regulators of the Target of Rapamycin (TOR) pathway in Drosophila melanogaster
- The Role of Mammalian Target of Rapamycin in the Regulation of Amino Acid Transporters in the Human Placenta
- Rapamycin, mTOR inhibitor, a potent inhibitor for the cell growth and proliferation by p21-dependent mitotic arrest in human gastric cancers
- Role of mechanistic Target of Rapamycin (mTOR) signaling in the crustacean molting gland
- … Scale Expansion of Human Dendritic Cells with Regulatory Function from Peripheral Blood Monocytes Employing Leukapheresis and Rapamycin for Clinical Trials.
- Angioplasty stenting with Sirolimus (Rapamycin) eluting stents in type 2 diabetic patients Angioplastia con stents liberadores de rapamicina en diabéticos tipo 2 …
- Rapamycin prevents tobacco-carcinogen induced lung tumorigenesis and selectively reduces lung-associated Foxp3 positive cells
- Clinical observation of Rapamycin Eluting Stent in acute ST-segment elevated myocardial infarction between domestic and imported product
- Targeted therapy for osteosarcoma using 17AAG and Rapamycin: identification of new targets using l Gene microarray profiling and proteomics
- EARLY IMMUNOSUPPRESSION WEANING AFTER CADAVER LIVER TRANSPLANTATION USING ATG INDUCTION AND Rapamycin: 358
- inhibition effect of Rapamycin on acute graft-versus-host disease after allogeneic bone marrow transplantation in a murine model
- Dual inhibition of phosphoinositide 3-kinase and mammalian target of Rapamycin as a novel therapeutic approach in human ovarian carcinoma
- A small molecule inhibitor against kinase domain of mammalian target of Rapamycin (mTOR) causes autophagic cell death in glioblastoma
- Effects of Imatinib and Rapamycin on the mTOR/S6 Signal Transduction Pathway in CD33+ Cell of CML
- mTOR inhibitors Rapamycin and RAD001 (Everolimus) induce antiproliferative effects in GH3 cell line and human pituitary adenomas
- PNEUMONITIS FROM INHIBITORS OF THE MAMMALIAN TARGET OF Rapamycin (mTOR) IN PATIENTS WITH METASTATIC CANCER
- Targeted therapy for osteosarcoma using 17AAG and Rapamycin: Characterization of induced apoptosis and inhibition of mTOR and AKT/MAP kinase pathways
- Blockage of mTOR signaling pathway by Rapamycin contributes to inhibition of tumor cell proliferation in ALK-positive lymphoid cell strains
- The Yaa locus Confers Apoptosis, NF-κB and Rapamycin Signaling Resistance Through Multiple Receptors in C57BL/6J Mice (129.12)
- Domestic versus foreign Rapamycin-eluting stents for emergency percutaneous coronary intervention in elder patients with acute myocardial infarction: Randomized …
- Tumor suppressor gene ARHI (DIRAS3) is required for spontaneous and Rapamycin-induced autophagy in normal and ovarian cancer cells
- Complete Responses in Patients with Autoimmune Lymphoproliferative Syndrome (ALPS) Using the mTOR Inhibitor Sirolimus (Rapamycin)
- Signaling Downstream of Mammalian Target of Rapamycin Complex 1 (mTORC1) is Derepressed Following Treatment with L‐Asparaginase in the Liver of GCN2 …
- MESENCHYMAL STEM CELLS ATTENUATE ACUTE REJECTION AND SYNERGIZE WITH Rapamycin LEADING TO CARDIAC ALLOGRAFT TOLERANCE: 382
- inhibition of the mammalian target of Rapamycin (mTOR) for the chemoprevention of tobacco-carcinogen induced lung tumorigenesis
- mTORC1 inhibition with Rapamycin or LY294002 alone but not in combination leads to AKT phosphorylation via mTORC2 in melanoma cells
- Corrigendum to “Low-dose oral Rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis”[J …
- FK506 VERSUS Rapamycin HAVE DIFFERENT EFFECTS ON EXPRESSION OF ANGIOPOIETINS1, 2 AND TIE2 IN RAT RENAL ALLOGRAFT WITH CAN: 1925
- Combination Therapy Utilizing Murine Anti-Thymocyte Globulin (ATG) and Rapamycin for the Reversal of Overt Type 1 Diabetes in NOD Mice.
- Rapamycin REDUCES VASCULAR INJURY BUT EXACERBATES PROTEINURIA IN ASSOCIATION WITH inhibition OF VEGF AND VEGF-R IN CHRONIC …
- … Inhibitor Causes Growth inhibition, Cell Cycle Arrest, Apoptosis and Autophagic Cell Death in Mantle Cell Lymphoma Cell Lines: A Distinct Profile from Rapamycin.
- Rapamycin PREFERENTIALLY BLOCKS THE EXPANSION OF POTENTIALLY TOLEROGENIC PLASMACYTOID DENDRITIC CELLS IN VIVO: 2217
- Rapamycin DECREASES CHOLESTEROL EFFLUX AND ABCA1 PROTEIN EXPRESSION WITHIN THP-1 MACROPHAGES: 1931
- TARGETED DELIVERY OF Rapamycin TO DENDRITIC CELLS USING BIODEGRADABLE MICROPARTICLES IS HIGHLY EFFECTIVE IN SUPPRESSING THEIR …
- Mating Stimulates Protein Phosphorylation and Synthesis Via Rapamycin-and Wortmannin-Sensitive Pathways in the Male Accessory Glands of D. melanogaster
- Dietary induced insulin resistance is independent of mammalian target of Rapamycin complex 1 (mTORC1) activity in skeletal muscle of mice
- 191: Rapamycin inhibits endothelial cell recovery after hypoxic injury
- Enhancement of Mammalian Target of Rapamycin Complex-2 (TORC2) Kinase Activity by Fructose-2, 6-Bisphosphate.
- Effect of Rapamycin/Curcumin Co-Loaded Poly (Lactide-Co-Glycolide) Films on Blood Compatibility and Vascular Smooth Muscle Cell Proliferation
- COMBINE TGF-BETA/FC AND Rapamycin FOR REGULATORY T CELLS GENERATION AND ALLOGRAFT TOLERANCE INDUCTION.: 728
- The Wnt Agonist, SKL2020 Inhibits Neointimal Hyperplasia but Facilitates Re-Endothelialization, When Treated with Rapamycin in Porcine Coronary Artery Stent …
- IL-1β-DRIVEN ST2 EXPRESSION PROMOTES MATURATION RESISTANCE IN Rapamycin-CONDITIONED DENDRITIC CELLS: 643
- PRO-TOLEROGENIC PROPERTIES OF Rapamycin THAT FAVOR INDEFINITE HEART ALLOGRAFT SURVIVAL MEDIATED BY REGULATORY T CELLS.: 27
- Mechanism of luteolin-induced apoptosis through suppressing p21 (WAF1/CIP1) expression with Rapamycin in HER2-overexpressing cancer cells
- … ALLOGRAFT SURVIVAL IN UNMANIPULATED HOSTS BY POST-TRANSPLANT INFUSION OF DONOR-SPECIFIC REGULATORY T CELLS AND Rapamycin: 655
- Role of the mammalian Target of Rapamycin (mTOR) Complex 1 signaling in beta‐adrenergic‐stimulated triacylglycerol (TAG) lipolysis and free fatty acid (FFA) …
- A phase I study of the mTOR inhibitor sirolimus (Rapamycin) in combination with nanoparticle albumin-bound paclitaxel (ABI-007, abraxane) in advanced solid cancers
- IMPACT OF IMMUNOSUPPRESSION ON UV-INDUCED SKIN-TUMORS IN MICE: Rapamycin IMPAIRS TUMOR OUTGROWTH AND SHIFTS THE MUTATION …
- Dexamethasone represses signaling through mammalian target of Rapamycin (mTOR) in muscle cells by enhancing expression of REDD1
- inhibition of mammalian target of Rapamycin (mTOR) induces phosphatidylinositol 3 kinase-dependent and Mnk-mediated eIF4E phosphorylation
- Rapamycin, mTOR Inhibitor, a Potent Cell Growth and Proliferation Inhibitor by p21-Dependent Mitotic Arrest in Human Gastric Cancers
- Rapamycin PROMOTES THE ENRICHMENT OF CD4+ CD25HIFOXP3+ T REGULATORY CELLS FROM NAIVE CD4+ T CELLS OF BABOON THAT SUPPRESS …
- … with drug eluting stents but with significant cost saving: long term follow up results from the randomized, controlled ORAR III (Oral Rapamycin in Argentina) Study
- PD2-4 Survival Advantage of Temsirolimus Validates a Role for Mammalian Target of Rapamycin (mTOR) in the Biology of Advanced Renal Cell Carcinoma
- P3-026: A novel Bayesian dose-escalation Phase Ib study design investigating combination of the mammalian target of Rapamycin (mTOR) inhibitor RAD001 with …
- Cell cycle arrest and suppression of the Akt/mammalian target of Rapamycin signaling mediated by yuanhuadine, a daphnane diterpenoid, isolated from Daphne …
- … Smooth Muscle Cell Proliferation and Intimal Expansion by Phosphatidylinositol 3-Kinase–Dependent Mammalian Target of Rapamycin Raptor Complex 1 …
- 155. Tumor Necrosis In Vivo Caused by a Novel Combination of Sorafenib and Rapamycin: Targeting the RAS and Motor Pathways ION Hepatocellular Carcinoma
- 342: Rapamycin Prevents GVHD in Mouse Model through Novel Mechanism: Increase in Regulatory T cells
- … downregulates acetyl-CoA carboxylase alpha and fatty acid synthase by activating AMP-activated protein kinase and suppressing the mammalian target of Rapamycin …
- Glycogen Synthase Kinase-3 (GSK-3) Signaling to Mammalian Target of Rapamycin (mTOR) Regulates DNA Synthesis and Cell Cycle Progression in Rodent and …
- THROMBOSPONDIN-1 (TSP-1) MEDIATES THE ANTI ANGIOGENIC AND IMMUNOMODULATORY EFFECTS OF Rapamycin ON PANCREATIC ISLET …
- 53: Rapamycin Partially Overcomes the in vitro Protective Effect of M2–10B4 Mesenchymal Stromal Cells (MSC) to Murine mCGPR/+ Acute Promyelocytic Leukemic …
- … CXC Chemokine Receptor 4 (CXCR4) by Hypoxia and the Phosphatidylinositol 3‐Kinase (PI‐3‐K)/Mammalian Target of Rapamycin (mTOR) Signaling Pathway
- 234: Rapamycin generated donor Th2/Tc2 cells prevent graft rejection by inhibition of alloreactivity and not by deletion of alloreactive T cells
- FoxP3 Mediated Induction of Pim 2 Allows T Regulatory Cells to Preferentially Expand in Rapamycin
- The Novel Glycolysis Inhibitor, 3-BrOP, Has Broad Activity Against Acute Lymphoblastic Leukemias and Potentiates Methotrexate and Rapamycin.
- … -selective oncolytic adenovirus OBP-405 induces autophagic cell death and enhances the antitumor effect of temozolomide and Rapamycin on glioblastoma cells in …
- … regulatory (CD4+ CD25+ CD127LowFOXP3+) cells to high purity by inhibiting expansion of CD4+ CD25+ CD127HighFOXP3-conventional T cells with Rapamycin
- Late stage efficacy and regulated gene expression profiles by 5-aza-dC, valproic acid, suberoylanilide hydroxamic acid, and Rapamycin in mouse lung tumorigenesis
- 720: inhibition of Proliferation by Rapamycin in RAT Bladder Smooth Muscle Cells
- 307: Initial selection of high affinity CD25+ cells increases the purity of CD4+ CD25+ Foxp3+ T regulatory cells expanded in medium containing Rapamycin
- 518: Medium term renal function of pediatric heart transplant patients on reduced calcineurin inhibitor and Rapamycin
- Automated quantitative analysis of AKT/mTOR pathway in patients treated with nanoparticle albumin-bound paclitaxel (ABI-007, Abraxane) and (sirolimus) Rapamycin
- 51: Rapamycin and its influence on arterial vascular function after short-term incubation
- 336: Relative Contribution of CD127 Negative Selection, Rapamycin, and TGF-β to the Generation of Human Regulatory T Cells that Inhibit Alloreactivity via Dendritic …
- An ATP-competitive mammalian target of Rapamycin inhibitor reveals Rapamycin-resistant functions of mTORC1
- Rapamycin decelerates cellular senescence
- Structure of the human mTOR complex I and its implications for Rapamycin inhibition
- Delayed correlation of mRNA and protein expression in Rapamycin-treated cells and a role for Ggc1 in cellular sensitivity to Rapamycin
- Rapamycin inhibits mTORC1, but not completely
- Mammalian target of Rapamycin: discovery of Rapamycin reveals a signaling pathway important for normal and cancer cell growth
- Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- Mechanisms of life span extension by Rapamycin in the fruit fly Drosophila melanogaster
- Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson’s Disease
- Targeting mTOR with Rapamycin: one dose does not fit all
- The role of the mammalian target of Rapamycin (mTOR) in renal disease
- Mammalian target of Rapamycin (mTOR): conducting the cellular signaling symphony
- Potential use of Rapamycin in HIV infection
- Targeting mTOR globally in cancer: thinking beyond Rapamycin
- The complexes of mammalian target of Rapamycin
- The mammalian target of Rapamycin: linking T cell differentiation, function, and metabolism
- Not all substrates are treated equally: Implications for mTOR, Rapamycin-resistance, and cancer therapy
- Rapamycin-induced phosphaturia
- The mammalian target of Rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
- Mammalian target of Rapamycin complex 1: signalling inputs, substrates and feedback mechanisms
- Rapamycin administration in humans blocks the contraction‐induced increase in skeletal muscle protein synthesis
- Rapamycin extends maximal lifespan in cancer-prone mice
- Active-site inhibitors of mTOR target Rapamycin-resistant outputs of mTORC1 and mTORC2
- Nutrient-dependent regulation of autophagy through the target of Rapamycin pathway
- Biosynthesis of Rapamycin and its regulation: past achievements and recent progress
- inhibition of mTOR by Rapamycin abolishes cognitive deficits and reduces amyloid-β levels in a mouse model of Alzheimer’s disease
- SIRT1 negatively regulates the mammalian target of Rapamycin
- Targeting mammalian target of Rapamycin by Rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model
- Characterization of the Rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis
- Rapamycin and quasi-programmed aging: Four years later
- A versatile role of mammalian target of Rapamycin in human dendritic cell function and differentiation
- Autophagy is required for extension of yeast chronological life span by Rapamycin
- Rapid inactivation of proteins by Rapamycin-induced rerouting to mitochondria
- Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of Rapamycin
- Ku-0063794 is a specific inhibitor of the mammalian target of Rapamycin (mTOR)
- Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
- GOLPH3 modulates mTOR signalling and Rapamycin sensitivity in cancer
- Molecular interplay between mammalian target of Rapamycin (mTOR), amyloid-β, and Tau: effects on cognitive impairments
- A Rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states
- Resveratrol and Rapamycin: are they anti‐aging drugs?
- Metformin and Rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
- Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of Rapamycin
- Rapamycin protects against rotenone-induced apoptosis through autophagy induction
- Protein synthesis is resistant to Rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia
- Rapamycin reduces seizure frequency in tuberous sclerosis complex
- Pharmacological inhibition of the mammalian target of Rapamycin pathway suppresses acquired epilepsy
- Preliminary characterization of oral lesions associated with inhibitors of mammalian target of Rapamycin in cancer patients
- TORC-specific phosphorylation of mammalian target of Rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2
- Total synthesis of Rapamycin
- Targeted inhibition of mammalian target of Rapamycin signaling inhibits tumorigenesis of colorectal cancer
- AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of Rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
- Tti1 and Tel2 are critical factors in mammalian target of Rapamycin complex assembly
- The mTOR pathway is highly activated in diabetic nephropathy and Rapamycin has a strong therapeutic potential
- Role for mammalian target of Rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders
- Dual inhibition of Akt/mammalian target of Rapamycin pathway by nanoparticle albumin-bound–Rapamycin and perifosine induces antitumor activity in multiple …
- Long-term Rapamycin therapy in the Han: SPRD rat model of polycystic kidney disease (PKD)
- Delivery of Rapamycin to dendritic cells using degradable microparticles
- Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and Rapamycin in vivo
- CDC25B mediates Rapamycin-induced oncogenic responses in cancer cells
- Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with Rapamycin
- Curcumin disrupts the Mammalian target of Rapamycin-raptor complex
- HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and Rapamycin combination therapy
- Chronic Rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose …
- Recent advances in the chemistry, biosynthesis and pharmacology of Rapamycin analogs
- inhibition of target of Rapamycin signaling and stress activate autophagy in Chlamydomonas reinhardtii
- Akt signals through the mammalian target of Rapamycin pathway to regulate CNS myelination
- Beneficial effects of Mammalian target of Rapamycin inhibition on left ventricular remodeling after myocardial infarction
- Mammalian target of Rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
- Activation of the mammalian target of Rapamycin (mTOR) is essential for oligodendrocyte differentiation
- The Rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates
- Sorafenib and Rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
- Mammalian target of Rapamycin: hitting the bull’s-eye for neurological disorders
- Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
- Mammalian target of Rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: from tuberous sclerosis to common acquired epilepsies
- inhibition of the mammalian target of Rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies
- A pharmacodynamic study of Rapamycin in men with intermediate-to high-risk localized prostate cancer
- Bone growth during Rapamycin therapy in young rats
- Regulation of placental amino acid transporter activity by mammalian target of Rapamycin
- Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity
- Mammalian target of Rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis
- Topical Rapamycin: a novel approach to facial angiofibromas in tuberous sclerosis
- New inhibitors of the mammalian target of Rapamycin signaling pathway for cancer
- Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses
- Mammalian target of Rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies
- Integration of general amino acid control and target of Rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast
- Specific roles of Target of Rapamycin in the control of stem cells and their progeny in the Drosophila ovary
- Down-regulation of Akt/mammalian target of Rapamycin signaling pathway in response to myostatin overexpression in skeletal muscle
- Infusion of mesenchymal stem cells and Rapamycin synergize to attenuate alloimmune responses and promote cardiac allograft tolerance
- Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
- Rapamycin inhibition of the Akt/mTOR Pathway Blocks Select Stages of VEGF-A164–Driven Angiogenesis, in Part by Blocking S6Kinase
- Rapamycin Protects Against High Fat Diet–Induced Obesity in C57BL/6J Mice
- Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer
- Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of Rapamycin in neonatal hypoxia-ischemia
- Overexpression of phosphorylated mammalian target of Rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer
- Mammalian target of Rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves
- Rapamycin promotes β-amyloid production via ADAM-10 inhibition
- Differential responses of human regulatory T cells (Treg) and effector T cells to Rapamycin
- Monitoring mammalian target of Rapamycin (mTOR) activity
- The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with Rapamycin in renal cell carcinoma
- Mammalian target of Rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats
- Treatment with Rapamycin prevents fibrosis in tight‐skin and bleomycin‐induced mouse models of systemic sclerosis
- Mammalian target of Rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage
- Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of Rapamycin (TOR) pathway
- Mammalian target of Rapamycin controls dendritic cell development downstream of Flt3 ligand signaling
- Comparison of human and rat uterine leiomyomata: identification of a dysregulated mammalian target of Rapamycin pathway
- Long‐term administration of Rapamycin reduces adiposity, but impairs glucose tolerance in high‐fat diet‐fed KK/HlJ mice
- Rapamycin inhibits hepatic fibrosis in rats by attenuating multiple profibrogenic pathways
- Regulation of insulin-like growth factor–mammalian target of Rapamycin signaling by microRNA in childhood adrenocortical tumors
- Rapamycin prevents transforming growth factor-α–induced pulmonary fibrosis
- Participation of mammalian target of Rapamycin complex 1 in Toll-like receptor 2–and 4–induced neutrophil activation and acute lung injury
- Use of Rapamycin in the induction of tolerogenic dendritic cells
- Rapamycin versus methotrexate in early diffuse systemic sclerosis: Results from a randomized, single‐blind pilot study
- Insights into the domain and repeat architecture of target of Rapamycin
- A novel mouse model of inflammatory bowel disease links mammalian target of Rapamycin-dependent hyperproliferation of colonic epithelium to inflammation …
- Nutrient availability and lactogenic hormones regulate mammary protein synthesis through the mammalian target of Rapamycin signaling pathway
- The mammalian target of Rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system
- … irinotecan and Rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of Rapamycin …
- Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability
- Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication
- Mammalian target of Rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
- Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of Rapamycin pathway
- Critical roles for mTORC2-and Rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
- inhibition of the mammalian target of Rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
- Oral Rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels
- Myxoma virus virotherapy for glioma in immunocompetent animal models: optimizing administration routes and synergy with Rapamycin
- inhibition of histone deacetylase overcomes Rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2
- Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway
- Synergistic effect of Rapamycin and cisplatin in endometrial cancer cells
- Activation of mammalian target of Rapamycin controls the loss of TCRζ in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation
- Mammalian target of Rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice
- Uremic cardiac hypertrophy is reversed by Rapamycin but not by lowering of blood pressure
- Testosterone induces cardiomyocyte hypertrophy through mammalian target of Rapamycin complex 1 pathway
- Rapamycin in islet transplantation: friend or foe?
- Mammalian target of Rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR
- Rapamycin, unlike cyclosporine A, enhances suppressive functions of in vitro-induced CD4+CD25+ Tregs
- Mammalian target of Rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis
- Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage?
- Distinct roles for mammalian target of Rapamycin complexes in the fibroblast response to transforming growth factor-β
- Expression of an activated mammalian target of Rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors
- The somatostatin analogue octreotide confers sensitivity to Rapamycin treatment on pituitary tumor cells
- Rapamycin regulates Akt and ERK phosphorylation through mTORC1 and mTORC2 signaling pathways
- Rapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis
- ATP-competitive inhibitors of the mammalian target of Rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines
- Gastric mammalian target of Rapamycin signaling regulates ghrelin production and food intake
- The potential benefits of Rapamycin on renal function, tolerance, fibrosis, and malignancy following transplantation
- Target of Rapamycin signaling in leukemia and lymphoma
- Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation
- Targeted inhibition of mammalian target of Rapamycin for the treatment of advanced renal cell carcinoma
- Target of Rapamycin (TOR) mediates the transduction of nutritional signals into juvenile hormone production
- Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice
- Phase II trial of the oral mammalian target of Rapamycin inhibitor everolimus in relapsed or refractory Waldenström macroglobulinemia
- Mammalian target of Rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma
- The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of Rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple …
- Mammalian target of Rapamycin: biological function and target for novel anticancer agents
- Mammalian target of Rapamycin signaling activation patterns in neuroendocrine tumors of the lung
- inhibition of mammalian target of Rapamycin as a therapeutic strategy in the management of bladder cancer
- Randomised trial of three Rapamycin-eluting stents with different coating strategies for the reduction of coronary restenosis: 2-year follow-up results
- inhibition of mammalian target of Rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells
- Perifosine inhibits mammalian target of Rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy
- The effect of Rapamycin on bone growth in rabbits
- Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs
- Efficacy of systemically administered oncolytic vaccinia virotherapy for malignant gliomas is enhanced by combination therapy with Rapamycin or cyclophosphamide
- Rapamycin induces transactivation of the EGFR and increases cell survival
- Mammalian target of Rapamycin inhibitors Rapamycin and RAD001 (everolimus) induce anti-proliferative effects in GH-secreting pituitary tumor cells in vitro
- Adiponectin modulates C-jun N-terminal kinase and mammalian target of Rapamycin and inhibits hepatocellular carcinoma
- B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates Rapamycin sensitivity in colorectal cancer
- High entrapment efficiency of chitosan/polylactic acid/tripolyphotspate nanosized microcapsules for Rapamycin by an emulsion-evaporation approach
- Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of Rapamycin inhibition
- Chemical genetics screen for enhancers of Rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase
- Immune regulation by Rapamycin: moving beyond T cells
- First report on a series of HIV patients undergoing Rapamycin monotherapy after liver transplantation
- … leucine content of a complete meal directs peak activation but not duration of skeletal muscle protein synthesis and mammalian target of Rapamycin signaling in rats
- Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model
- Rapamycin inhibits in vitro growth and release of angiogenetic factors in human bladder cancer
- Mammalian target of Rapamycin signaling modulates photic entrainment of the suprachiasmatic circadian clock
- The tuberous sclerosis proteins regulate formation of the primary cilium via a Rapamycin-insensitive and polycystin 1-independent pathway
- Phospho-mTOR and phospho-4EBP1 in endometrial adenocarcinoma: association with stage and grade in vivo and link with response to Rapamycin treatment in vitro
- Different effects of FK506, Rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets
- Downregulation of Akt/mammalian target of Rapamycin pathway in skeletal muscle is associated with increased REDD1 expression in response to chronic hypoxia
- Dual targeting of AKT and mammalian target of Rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor
- Mammalian target of Rapamycin in spinal cord neurons mediates hypersensitivity induced by peripheral inflammation
- Effect of Rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status
- Leptin modulates the survival of autoreactive CD4+ T cells through the nutrient/energy-sensing mammalian target of Rapamycin signaling pathway
- … skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of Rapamycin complex 1 signaling
- Signaling events downstream of mammalian target of Rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor …
- A phase I study of the mammalian target of Rapamycin inhibitor sirolimus and MEC chemotherapy in relapsed and refractory acute myelogenous leukemia
- Morpholine derivatives greatly enhance the selectivity of mammalian target of Rapamycin (mTOR) inhibitors
- Intravesical delivery of Rapamycin suppresses tumorigenesis in a mouse model of progressive bladder cancer
- Complex regulation of mammalian target of Rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status
- Mammalian target of Rapamycin regulates vascular endothelial growth factor–dependent liver cyst growth in polycystin‐2–defective mice
- Rapamycin sensitizes T-ALL cells to dexamethasone-induced apoptosis
- Generation of high-yield Rapamycin-producing strains through protoplasts-related techniques
- An expeditious route to fluorinated Rapamycin analogues by utilising mutasynthesis
- Mechanisms involved in the enhancement of mammalian target of Rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice
- Mammalian target of Rapamycin and diabetes: what does the current evidence tell us?
- Mammalian target of Rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients
- Treatment of refractory oral erosive lichen planus with topical Rapamycin: 7 cases
- Cryptotanshinone inhibits cancer cell proliferation by suppressing mammalian target of Rapamycin–mediated cyclin D1 expression and Rb phosphorylation
- Tubers and tumors: Rapamycin therapy for benign and malignant tumors
- The pre-clinical assessment of Rapamycin-eluting, durable polymer-free stent coating concepts
- Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus Rapamycin but not atorvastatin or doxycycline in tuberous …
- EGFR signaling through an Akt-SREBP-1–dependent, Rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy
- Rapamycin promotes arterial thrombosis in vivo: implications for everolimus and zotarolimus eluting stents
- Expansion of the target of Rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity
- Long‐term blood vessel removal with combined laser and topical Rapamycin antiangiogenic therapy: Implications for effective port wine stain treatment
- R1507, a fully human monoclonal antibody targeting IGF‐1R, is effective alone and in combination with Rapamycin in inhibiting growth of osteosarcoma xenografts
- EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of Rapamycin …
- Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model
- Mammalian target of Rapamycin signaling in the spinal cord is required for neuronal plasticity and behavioral hypersensitivity associated with neuropathy in …
- Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor p27Kip1
- Activated mammalian target of Rapamycin is a potential therapeutic target in gastric cancer
- Mutual regulation of hypoxia-inducible factor and mammalian target of Rapamycin as a function of oxygen availability
- Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients
- Rapamycin inhibits postprandial-mediated X-box-binding protein-1 splicing in rat liver
- inhibition of human T-cell proliferation by mammalian target of Rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5)
- Mammalian target of Rapamycin is activated in association with myometrial proliferation during pregnancy
- Expression status and prognostic significance of mammalian target of Rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy
- A phase 2 study of the oral mammalian target of Rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma
- Mammalian target of Rapamycin (mTOR) regulates TLR3 induced cytokines in human oral keratinocytes
- Rapamycin-mediated FOXO1 inactivation reduces the anticancer efficacy of Rapamycin
- Rapamycin for refractory acute graft-versus-host disease
- Life span extension by resveratrol, Rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging
- Nucleus accumbens core mammalian target of Rapamycin signaling pathway is critical for cue-induced reinstatement of cocaine seeking in rats
- New approach for local delivery of Rapamycin by bioadhesive PLGA-carbopol nanoparticles
- Activation of the mammalian target of Rapamycin signalling pathway in prostate cancer and its association with patient clinicopathological characteristics
- … triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c‐Jun N‐terminal kinase, Akt and mammalian target of Rapamycin …
- Rapamycin induces autophagic flux in neurons
- Development and characterization of liposomal formulations for Rapamycin delivery and investigation of their antiproliferative effect on MCF7 cells
- A pilot trial of the mTOR (mammalian target of Rapamycin) inhibitor RAD001 in patients with advanced B-CLL
- Survival benefit with proapoptotic molecular and pathologic responses from dual targeting of mammalian target of Rapamycin and epidermal growth factor …
- Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of Rapamycin (mTOR): Optimization of the 1-substituent
- A randomized optical coherence tomography study of coronary stent strut coverage and luminal protrusion with Rapamycin-eluting stents
- The target of Rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway
- Mammalian target of Rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy
- Rapamycin (sirolimus) in tuberous sclerosis associated pediatric central nervous system tumors
- Targeted therapy of human osteosarcoma with 17AAG or Rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways
- Conversion to Rapamycin immunosuppression for malignancy after kidney transplantation
- cAMP-dependent activation of mammalian target of Rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4
- Immunosuppression using the mammalian target of Rapamycin (mTOR) inhibitor everolimus: pilot study shows significant cognitive and affective improvement
- Late progression of renal pathology and cyst enlargement is reduced by Rapamycin in a mouse model of nephronophthisis
- Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitors
- Oral Rapamycin reduces tumour burden and vascularization in Lkb1+/− mice
- Rapamycin and MPA, but not CsA, impair human NK cell cytotoxicity due to differential effects on NK cell phenotype
- NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
- Broadening the therapeutic scope for Rapamycin treatment
- Dual phosphoinositide 3-kinase/mammalian target of Rapamycin blockade is an effective radiosensitizing strategy for the treatment of non–small cell lung cancer …
- Upregulation of the mammalian target of Rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic β-cells leads to increased β-cell mass and …
- mTORC1 inhibition via Rapamycin promotes triacylglycerol lipolysis and release of free fatty acids in 3T3-L1 adipocytes
- Mammalian target of Rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis
- Effects of metformin on mammalian target of Rapamycin in a mouse model of endometrial hyperplasia
- Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC Min/+ mice
- Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by Rapamycin
- Early and late effects of the immunosuppressants Rapamycin and mycophenolate mofetil on UV carcinogenesis
- Curcumin inhibits carcinogen and nicotine-induced Mammalian target of Rapamycin pathway activation in head and neck squamous cell carcinoma
- Differing effects of systemically administered Rapamycin on consolidation and reconsolidation of context vs. cued fear memories
- The antidepressant sertraline inhibits translation initiation by curtailing mammalian target of Rapamycin signaling
- Vascular endothelial growth factor-C protects prostate cancer cells from oxidative stress by the activation of mammalian target of Rapamycin complex-2 and AKT-1
- Rapamycin-induced Gln3 dephosphorylation is insufficient for nuclear localization: Sit4 and PP2A phosphatases are regulated and function differently
- Melatonin attenuates methamphetamine‐induced deactivation of the mammalian target of Rapamycin signaling to induce autophagy in SK‐N‐SH cells
- Monotherapy Rapamycin allows an increase of CD4+ CD25bright+ FoxP3+ T cells in renal recipients
- Rapamycin: the cure for all that ails
- Activation of mammalian target of Rapamycin signaling in spatial learning
- Dual inhibition of mitogen-activated protein kinase kinase and mammalian target of Rapamycin in differentiated and anaplastic thyroid cancer
- Comparison of radiosensitizing effects of the mammalian target of Rapamycin inhibitor CCI-779 to cisplatin in experimental models of head and neck squamous cell …
- The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling network in normal myelopoiesis and leukemogenesis
- MYC activity mitigates response to Rapamycin in prostate cancer through eukaryotic initiation factor 4E–binding protein 1–mediated inhibition of autophagy
- Successful control of intractable hypoglycemia using Rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases
- Generation of high Rapamycin producing strain via rational metabolic pathway‐based mutagenesis and further titer improvement with fed‐batch bioprocess …
- Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia
- Rapamycin-Insensitive Up-Regulation of MMP2 and Other Genes in Tuberous Sclerosis Complex 2–Deficient Lymphangioleiomyomatosis-Like Cells
- Increasing longevity through caloric restriction or Rapamycin feeding in mammals: common mechanisms for common outcomes?
- Rapamycin inhibits anal carcinogenesis in two preclinical animal models
- Overexpression of the mammalian target of Rapamycin: a novel biomarker for poor survival in resected early stage non-small cell lung cancer
- Mammalian target of Rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein–protein interactions …
- Downregulation of Notch pathway by a γ-secretase inhibitor attenuates AKT/mammalian target of Rapamycin signaling and glucose uptake in an ERBB2 transgenic …
- A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of Rapamycin signaling is sufficient to induce skeletal muscle hypertrophy
- … -1, 3, 5-triazine) derivatives: potent adenosine 5′-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of Rapamycin inhibitors: discovery of …
- Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-α expression in macrophages by reducing IL-10 expression
- Rapamycin protects mice from staphylococcal enterotoxin B-induced toxic shock and blocks cytokine release in vitro and in vivo
- Pneumonitis associated with mammalian target of Rapamycin inhibitors in renal transplant recipients: a single-center experience
- Discovery of potent and selective inhibitors of the mammalian target of Rapamycin (mTOR) kinase
- Antimyeloma activity of the orally bioavailable dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235
- Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway
- Mammalian target of Rapamycin is a biomarker of poor survival in metastatic serous ovarian carcinoma
- Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of Rapamycin/S6 kinase 2 pathway
- Treatment with Rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces …
- Rapamycin and CCI‐779 inhibit the mammalian target of Rapamycin signalling in hepatocellular carcinoma
- mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies Rapamycin mechanism of action
- Preclinical in vivo evaluation of Rapamycin in human malignant peripheral nerve sheath explant xenograft
- Hypersensitivity of Ph-positive lymphoid cell lines to Rapamycin: Possible clinical application of mTOR inhibitor
- Mammalian target of Rapamycin complex 1 is involved in differentiation of regenerating myofibers in vivo
- Rapamycin as a therapy of choice after renal transplantation in a patient with tuberous sclerosis complex
- Treating triple-negative breast cancer by a combination of Rapamycin and cyclophosphamide: an in vivo bioluminescence imaging study
- Antitumoral activity of Rapamycin mediated through inhibition of HIF-1alpha and VEGF in hepatocellular carcinoma
- Aberrant hyperactivation of akt and Mammalian target of Rapamycin complex 1 signaling in sporadic chordomas
- HIV-associated nephropathy: role of mammalian target of Rapamycin pathway
- The Rapamycin-regulated gene expression signature determines prognosis for breast cancer
- … acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2Δ) mutants is influenced by the carbon source and Rapamycin
- Combined Bcl-2/Mammalian Target of Rapamycin inhibition Leads to Enhanced Radiosensitization via Induction of Apoptosis and Autophagy in Non–Small Cell Lung …
- Rapamycin down-regulates inducible nitric oxide synthase by inducing proteasomal degradation
- Functional interaction of mammalian target of Rapamycin complexes in regulating mammalian cell size and cell cycle
- Efficacy, tolerance, and safety of mammalian target of Rapamycin inhibitors as rescue immunosuppressants in liver transplantation
- Rapamycin induces the TGFβ1/Smad signaling cascade in renal mesangial cells upstream of mTOR
- … 3-kinase (PI3K) and the mammalian target of Rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel wortmannin− Rapamycin conjugates
- Developing antiepileptogenic drugs for acquired epilepsy: targeting the mammalian target of Rapamycin (mTOR) pathway
- Hepatitis C virus NS5A activates the mammalian target of Rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between …
- Naive CD4 t cell proliferation is controlled by mammalian target of Rapamycin regulation of GRAIL expression
- Activation of the mammalian target of Rapamycin signalling pathway in epidermal tumours and its correlation with cyclin‐dependent kinase 2
- The effects of Rapamycin on lens epithelial cell proliferation, migration, and matrix formation: an in vitro study
- Distinct phosphatase requirements and GATA factor responses to nitrogen catabolite repression and Rapamycin treatment in Saccharomyces cerevisiae
- Rapamycin induces growth retardation by disrupting angiogenesis in the growth plate
- … protects mouse and human hematopoietic progenitors from γ-irradiation through extracellular signal-regulated kinase/mammalian target of Rapamycin …
- Rapamycin inhibits cell proliferation in type I and type II endometrial carcinomas: a search for biomarkers of sensitivity to treatment
- Dramatic improvement in pulmonary hypertension with Rapamycin
- High expression of mammalian target of Rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma
- Phase Ib study of weekly mammalian target of Rapamycin inhibitor ridaforolimus (AP23573; MK-8669) with weekly paclitaxel
- Expression of EBV latent antigens, mammalian target of Rapamycin, and tumor suppression genes in EBV-positive smooth muscle tumors: clinical and therapeutic …
- Identification of functional FKB protein in Echinococcus granulosus: its involvement in the protoscolicidal action of Rapamycin derivates and in calcium homeostasis
- The role of phosphoinositide 3‐kinase and phosphatidic acid in the regulation of mammalian target of Rapamycin following eccentric contractions
- Placental mammalian target of Rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction
- Rapamycin inhibits proliferation and migration of hepatoma cells in vitro
- TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers Rapamycin sensitivity
- Rapamycin response in tumorigenic and non-tumorigenic hepatic cell lines
- Activation of the AKT and mammalian target of Rapamycin pathways and the inhibitory effects of Rapamycin on those pathways in canine malignant melanoma cell lines
- Rapamycin as an alternative to surgical treatment of subependymal giant cell astrocytomas in a patient with tuberous sclerosis complex: Case report
- Rapamycin-eluting stents in the arterial duct: experimental observations in the pig model.
- Device-based local delivery of siRNA against mammalian target of Rapamycin (mTOR) in a murine subcutaneous implant model to inhibit fibrous encapsulation
- mTOR inhibitor Rapamycin alone or combined with cisplatin inhibits growth of esophageal squamous cell carcinoma in nude mice
- Exploring mammalian target of Rapamycin (mTOR) inhibition for treatment of mantle cell lymphoma and other hematologic malignancies
- Target of Rapamycin (TOR)-like 1 kinase is involved in the control of polyphosphate levels and acidocalcisome maintenance in Trypanosoma brucei
- Rapid modification of proteins using a Rapamycin-inducible tobacco etch virus protease system
- Concurrent and sequential administration of chemotherapy and the Mammalian target of Rapamycin inhibitor temsirolimus in human cancer cells and xenografts
- Mammalian target of Rapamycin complex 1 (mTORC1) signaling in energy balance and obesity
- Bortezomib can suppress activation of Rapamycin-resistant memory T cells without affecting regulatory T-cell viability in non-human primates
- Rapamycin Prevents and Breaks the Anti-CD3–Induced Tolerance in NOD Mice
- Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD
- Polylactide-glycoli acid and Rapamycin coating intraocular lens prevent posterior capsular opacification in rabbit eyes
- Regulation of cell death and epileptogenesis by the mammalian target of Rapamycin (mTOR): a double-edged sword?
- Rapamycin inhibits growth of cholangiocarcinoma cells.
- The Insulin-like Growth Factor-1 Receptor–Targeting Antibody, CP-751,871, Suppresses Tumor-Derived VEGF and Synergizes with Rapamycin in Models of …
- Rapamycin induces autophagy in islets: relevance in islet transplantation
- Mammalian target of Rapamycin inhibition abrogates insulin-mediated mammary tumor progression in type 2 diabetes
- Long-term clinical results following stenting of the left main stem: insights from RESEARCH (Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology Hospital) …
- Rapamycin by itself and additively in combination with carboplatin inhibits the growth of ovarian cancer cells
- Evaluation of in vivo antineoplastic effects of Rapamycin in patients with chemotherapy-refractory AML
- Expression and mechanism of mammalian target of Rapamycin in age-related renal cell senescence and organ aging
- Rapid improvement of nephrogenic systemic fibrosis with Rapamycin therapy: possible role of phospho-70-ribosomal-S6 kinase
- Inactivation of mammalian target of Rapamycin increases STAT1 nuclear content and transcriptional activity in α4-and protein phosphatase 2A-dependent …
- Testing intravitreal toxicity of Rapamycin in rabbit eyes
- Antagonism of the mammalian target of Rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant …
- ATP-mediated protein kinase B Akt/mammalian target of Rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway activation promotes …
- Delayed re-endothelialization with Rapamycin-coated stents is rescued by the addition of a glycogen synthase kinase-3β inhibitor
- Regulation of gene expression in hepatic cells by the mammalian Target of Rapamycin (mTOR)
- inhibition of mammalian target of Rapamycin signaling potentiates the effects of all‐trans retinoic acid to induce growth arrest and differentiation of human acute …
- Rapamycin enhances chemotherapy‐induced cytotoxicity by inhibiting the expressions of TS and ERK in gastric cancer cells
- Pilot study: Rapamycin in advanced hepatocellular carcinoma
- Mammalian target of Rapamycin as a novel target in the treatment of hepatocellular carcinoma.
- Mammalian target of Rapamycin: a new target in prostate cancer
- MAPK, phosphatidylinositol 3-kinase, and mammalian target of Rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic …
- Rapamycin delays tumor development in murine livers by inhibiting proliferation of hepatocytes with DNA damage
- The Rapamycin-derivative RAD001 (everolimus) inhibits cell viability and interacts with the Akt–mTOR–p70S6K pathway in human medullary thyroid carcinoma cells
- Rapamycin and the transcription factor C/EBPβ as a switch in osteoclast differentiation: implications for lytic bone diseases
- Mammalian target of Rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma …
- Rapamycin inhibits lung metastasis of B16 melanoma cells through down‐regulating alphav integrin expression and up‐regulating apoptosis signaling
- Mammalian target of Rapamycin (mTOR) induces proliferation and de-differentiation responses to three coordinate pathophysiologic stimuli (mechanical strain …
- PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) inhibitor
- Effect of Rapamycin on lifespan in Drosophila
- Luteinizing hormone stimulates mammalian target of Rapamycin signaling in bovine luteal cells via pathways independent of AKT and mitogen-activated protein kinase …
- The effect of Rapamycin on angiogenesis in chick chorioalantoic membrane
- Mammalian target of Rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual …
- Regulation of gastric hormones by systemic Rapamycin
- Effect of combination treatment of Rapamycin and isoflavones on mTOR pathway in human glioblastoma (U87) cells
- Distinct subsets of Sit4 holophosphatases are required for inhibition of Saccharomyces cerevisiae growth by Rapamycin and zymocin
- Activation of phosphatidylinositol 3-kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine …
- Rapamycin inhibits re-endothelialization after percutaneous coronary intervention by impeding the proliferation and migration of endothelial cells and …
- Critical and diverse involvement of Akt/mammalian target of Rapamycin signaling in human lung carcinomas
- … yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for …
- Phosphoinositide 3-kinase (PI3K) and the nutrient sensing mTOR (mammalian target of Rapamycin) pathways control T cell migration
- Glycogen synthase kinase-3 and mammalian target of Rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets
- Periadventitial Rapamycin-eluting microbeads promote vein graft disease in long-term pig vein-into-artery interposition grafts
- Inhibitory effect of Rapamycin and dexamethasone on production of IL-17 and IFN-γ in Vogt–Koyanagi–Harada patients
- Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of Rapamycin complex 1 to enhance proliferation
- Novel mechanism of reducing tumourigenesis: upregulation of the DNA repair enzyme OGG1 by Rapamycin-mediated AMPK activation and mTOR inhibition
- Rapamycin‐Conditioned Donor Dendritic Cells Differentiate CD4+CD25+Foxp3+ T Cells In Vitro with TGF‐β1 for Islet Transplantation
- Mammalian Target of Rapamycin–Dependent Acinar Cell Neoplasia after Inactivation of Apc and Pten in the Mouse Salivary Gland: Implications for Human Acinic Cell …
- The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of Rapamycin
- Rescue immunosuppression with mammalian target of Rapamycin inhibitor drugs in liver transplantation
- In-vitro release of Rapamycin from a thermosensitive polymer for the inhibition of vascular smooth muscle cell proliferation
- Influence of combined treatment of low dose Rapamycin and cyclosporin A on corneal allograft survival
- Low-dose Rapamycin reduces kidney volume angiomyolipomas and prevents the loss of renal function in a patient with tuberous sclerosis complex
- Rapamycin attenuates the severity of murine adriamycin nephropathy
- Rapamycin and curcumin induce apoptosis in primary resting B chronic lymphocytic leukemia cells
- Stage 2 combination testing of Rapamycin with cytotoxic agents by the Pediatric Preclinical Testing Program
- Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma
- Human Protein Phosphatase PP6 Regulatory Subunits Provide Sit4-Dependent and Rapamycin–Sensitive Sap Function in Saccharomyces cerevisiae
- … cell marker upregulation in normal cutaneous vessels following pulsed‐dye laser exposure and its abrogation by concurrent Rapamycin administration: implications for …
- Monitoring kidney and renal cyst volumes applying MR approaches on a Rapamycin treated mouse model of ADPKD
- Rapamycin promotes the expansion of CD4+ Foxp3+ regulatory T cells after liver transplantation
- … cells treated with mammalian target of Rapamycin inhibitors: rationale for combined treatment with extracellular signal–regulated kinase inhibitors and Rapamycin
- Effective treatment of advanced colorectal cancer by Rapamycin and 5-FU/oxaliplatin monitored by TIMP-1
- Anti-CD154 mAb and Rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation
- Rictor phosphorylation on the Thr-1135 site does not require mammalian target of Rapamycin complex 2
- Comparison of three Rapamycin dosing schedules in A/J Tsc2+/-mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice …
- Effect of Rapamycin on cue-induced drug craving in abstinent heroin addicts
- Adenosine 5′-monophosphate-activated protein kinase-mammalian target of Rapamycin cross talk regulates brown adipocyte differentiation
- Intracellular parasitism with Toxoplasma gondii stimulates mammalian‐target‐of‐Rapamycin‐dependent host cell growth despite impaired signalling to S6K1 and 4E …
- Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of Rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia
- The synergic effects of Rapamycin and extremely low frequency electromagnetic field on angiogenesis
- Rapamycin therapy for renal, brain, and skin lesions in a tuberous sclerosis patient
- Rapamycin effects on mTOR signaling in benign, premalignant and malignant human breast epithelial cells
- Combined inhibition of MEK and mammalian target of Rapamycin abolishes phosphorylation of cyclin-dependent kinase 4 in glioblastoma cell lines and prevents their …
- Structural basis for the association of the redox-sensitive target of Rapamycin FATC domain with membrane-mimetic micelles
- NV‐128, a novel isoflavone derivative, induces caspase‐independent cell death through the Akt/mammalian target of Rapamycin pathway
- Activating transcription factor 4 and CCAAT/enhancer-binding protein-β negatively regulate the mammalian target of Rapamycin via Redd1 expression in response to …
- Epidermal growth factor receptor and mammalian target of Rapamycin as therapeutic targets in malignant glioma: current clinical status and perspectives
- Chemopreventive efficacy of Rapamycin on Peutz–Jeghers syndrome in a mouse model
- … Stents Results in Better Clinical Outcomes During 6-Year Follow-Up Than Bare-Metal Stents: An Analysis of the RESEARCH (Rapamycin-Eluting Stent Evaluated At …
- … repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of Rapamycin …
- … of the epidermal growth factor receptor/mammalian target of Rapamycin pathway by epidermal growth factor receptor inhibitors and Rapamycin results in reduced cell …
- inhibition of the mammalian target of Rapamycin promotes cyclic AMP-induced differentiation of NG108-15 cells
- Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase–protein kinase B–mammalian target of Rapamycin signaling
- The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling network in cancer stem cell biology
- … -6-aryl-1H-pyrazolo[3,4-d]pyrimidines as Highly Potent and Selective ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the …
- PI3K signaling regulates Rapamycin-insensitive translation initiation complex formation in vaccinia virus-infected cells
- Silymarin inhibits endothelial progenitor cells’ senescence and protects against the antiproliferative activity of Rapamycin: preliminary study
- inhibition of voltage-gated K+ channels in dendritic cells by Rapamycin
- Phase I study of the oral mammalian target of Rapamycin inhibitor everolimus (RAD001) in Japanese patients with relapsed or refractory non-Hodgkin lymphoma
- Regulation by FK506 and Rapamycin of Ca2+ release from the sarcoplasmic reticulum in vascular smooth muscle: the role of FK506 binding proteins and mTOR
- … using bare-metal and drug-eluting stents in previously untreated coronary artery disease: insights from the RESEARCH (Rapamycin-Eluting Stent Evaluated at …
- Rrd1 isomerizes RNA polymerase II in response to Rapamycin
- Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of Rapamycin activity and p27Kip1 …
- Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism
- If mammalian target of metformin indirectly is mammalian target of Rapamycin, then the insulin-like growth factor-1 receptor axis will audit the efficacy of metformin in …
- The transcription factor SP1 regulates centriole function and chromosomal stability through a functional interaction with the mammalian target of Rapamycin/raptor …
- Involvement of autophagy via mammalian target of Rapamycin (mTOR) inhibition in tributyltin-induced neuronal cell death
- Rapamycin protects heart from ischemia/reperfusion injury independent of autophagy by activating PI3 kinase-Akt pathway and mitochondria KATP channel
- … peroxisome proliferator-activated receptor (PPAR) γ protein translation by suppressing the mammalian target of Rapamycin (mTOR) signaling pathway in …
- SP600125 negatively regulates the mammalian target of Rapamycin via ATF4-induced Redd1 expression
- … in the phosphoinositide 3-kinase/Akt signaling pathway confer sensitivity of thyroid cancer cells to therapeutic targeting of Akt and mammalian target of Rapamycin
- Rapamycin Inhibits VEGF‐Induced Microvascular Hyperpermeability In Vivo
- Iron deficiency down-regulates the Akt/TSC1-TSC2/mammalian Target of Rapamycin signaling pathway in rats and in COS-1 cells
- Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of Rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a …
- Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by Rapamycin in human myeloma cells
- Rapamycin for focal segmental glomerulosclerosis: a report of 3 cases
- inhibition of mammalian target of Rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E …
- Regression of left ventricular hypertrophy in kidney transplant recipients: the potential role for inhibition of mammalian target of Rapamycin
- … by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein of Rapamycin …
- Rapamycin inhibits cholangiocyte regeneration by blocking interleukin‐6–induced activation of signal transducer and activator of transcription 3 after liver …
- A role for mammalian target of Rapamycin–mTOR-pathway in non alcoholic steatohepatitis related-cirrhosis
- Targeting mammalian target of Rapamycin to both downregulate and disable the P-glycoprotein pump in multidrug-resistant B-cell lymphoma cell lines
- Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin with Rapamycin plus tacrolimus in liver transplant patient
- Rapamycin promotes the enrichment of CD4+ CD25hiFoxP3+ T regulatory cells from naive CD4+ T cells of baboon that suppress antiporcine xenogenic response in …
- Rapamycin, but not cyclosporine A, inhibits vascularization and incorporation of implanted surgical meshes
- Rapamycin‐treated mature dendritic cells have a unique cytokine secretion profile and impaired allostimulatory capacity
- Rapamycin induces autophagy and exacerbates metabolism associated complications in a mouse model of type 1 diabetes
- Effective inhibition of xenografts of hepatocellular carcinoma (HepG2) by Rapamycin and bevacizumab in an intrahepatic model
- Inducible somatic oocyte destruction in response to Rapamycin requires wild-type regulation of follicle cell epithelial polarity
- Cutaneous T‐cell lymphoma cells are sensitive to Rapamycin
- … ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase–regulated mammalian target of Rapamycin …
- Mammalian target of Rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function
- Rapamycin enhances the susceptibility of both androgen-dependent and-independent prostate carcinoma cells to docetaxel
- The phosphatidylinositol 3-kinase-AKT-mammalian target of Rapamycin signaling network and the control of normal myelopoiesis
- CD4+ Foxp3+ regulatory T cells converted by Rapamycin from peripheral CD4+ CD25˜. naive T cells display more potent regulatory abilityin vitro
- Chemistry and pharmacology of Rapamycin and its derivatives
- Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of Rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and …
- Mammalian target of the Rapamycin pathway is involved in non-alcoholic fatty liver disease
- Antiproliferative effects of Rapamycin and celecoxib in angiosarcoma cell lines
- Phase 1 and pharmacokinetic study of everolimus, a mammalian target of Rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung …
- mTOR inhibitor Rapamycin suppresses striatal post-ischemic LTP
- Ribosomal protein S6 kinase is a critical downstream effector of the target of Rapamycin complex 1 for long-term facilitation in Aplysia
- FK506 and Rapamycin neuroprotect erection and involve different immunophilins in a rat model of cavernous nerve injury
- Rapamycin increases the p53/MDM2 protein ratio and p53-dependent apoptosis by translational inhibition of mdm2 in cancer cells
- MCF-7 breast cancer cells selected for tamoxifen resistance acquire new phenotypes differing in DNA content, phospho-HER2 and PAX2 expression, and Rapamycin …
- Lysosomal accumulation of mTOR is enhanced by Rapamycin
- Systemic Rapamycin without loading dose for restenosis prevention after coronary bare metal stent implantation
- Beclin 1 self‐association is independent of autophagy induction by amino acid deprivation and Rapamycin treatment
- High expression levels of the mammalian target of Rapamycin inhibitor DEPTOR are predictive of response to thalidomide in myeloma
- … of the effects of NF-κB or PI3K pathway inhibitors on the LPS-induced gene expression profile in RAW264. 7 cells: synergistic effects of Rapamycin on LPS-induced …
- Combined administration of a mutant TGF-β1/Fc and Rapamycin promotes induction of regulatory T cells and islet allograft tolerance
- Evidence for cell cycle-dependent, Rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244
- Rapamycin reduces high-amplitude, mechanical stretch-induced apoptosis in pulmonary microvascular endothelial cells
- Effect of low-dose Rapamycin on tumor growth in two human hepatocellular cancer cell lines
- The serine 2481-autophosphorylated form of mammalian Target Of Rapamycin (mTOR) is localized to midzone and midbody in dividing cancer cells
- Rapamycin: could it enhance vaccine efficacy?
- Rapamycin and tacrolimus differentially modulate acute graft‐versus‐host disease in rats after liver transplantation
- Infarct size is increased in female post-MI rats treated with Rapamycin
- Protein kinase C-δ and phosphatidylinositol 3-kinase/Akt activate mammalian target of Rapamycin to modulate NF-κB activation and intercellular adhesion …
- Glutamate-dependent phosphorylation of the mammalian target of Rapamycin (mTOR) in Bergmann glial cells
- Rapid regression of lymphadenopathy upon Rapamycin treatment in a child with autoimmune lymphoproliferative syndrome
- Lead optimization of N-3-substituted 7-morpholinotriazolopyrimidines as dual phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitors: discovery of PKI …
- mTOR, the mammalian target of Rapamycin
- Oral Rapamycin attenuates atherosclerosis without affecting the arterial responsiveness of resistance vessels in apolipoprotein E-deficient mice
- Glucagon acts in a dominant manner to repress insulin-induced mammalian target of Rapamycin complex 1 signaling in perfused rat liver
- Targeting heat‐shock protein 90 improves efficacy of Rapamycin in a model of hepatocellular carcinoma in mice
- Rapamycin, the mTOR kinase inhibitor, sensitizes acute myeloid leukemia cells, HL-60 cells, to the cytotoxic effect of arabinozide cytarabine
- inhibition of human immunodeficiency virus (HIV‐1) infection in human peripheral blood leucocytes‐SCID reconstituted mice by Rapamycin
- Mammalian target of Rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells
- Effects of Rapamycin on prostate cancer PC-3 cells
- Five‐year clinical outcomes after coronary stenting of chronic total occlusion using sirolimus‐eluting stents: Insights from the Rapamycin‐eluting stent evaluated at …
- … of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not Rapamycin
- Failed rescue therapy with Rapamycin after paraquat intoxication
- mTOR pathway inhibitors in cancer therapy: moving past Rapamycin
- A spectrophotometric assay for routine measurement of mammalian target of Rapamycin activity in cell lysates
- Rhabdomyolysis and acute kidney injury secondary to concomitant use of fluvastatin and Rapamycin in a renal transplant recipient
- Rapamycin in combination with donor-specific CD4+ CD25+ Treg cells amplified in vitro might be realize the immune tolerance in clinical organ transplantation
- Shiga toxin 1-induced proinflammatory cytokine production is regulated by the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling pathway
- Triazines incorporating (R)-3-methylmorpholine are potent inhibitors of the mammalian target of Rapamycin (mTOR) with selectivity over PI3Kα
- Timing of conversion to mammalian target of Rapamycin inhibitors is crucial in liver transplant recipients with impaired renal function at transplantation
- Novel benzofuran-3-one indole inhibitors of PI3 kinase-α and the mammalian target of Rapamycin: Hit to lead studies
- Fission yeast TOR and Rapamycin
- Activated mammalian target of Rapamycin is associated with T regulatory cell insufficiency in nasal polyps
- Rapamycin or tacrolimus alone fails to resist cardiac allograft accelerated rejection mediated by alloreactive CD4+ memory T cells in mice
- A functional link between polo-like kinase 1 and the mammalian target-of-Rapamycin pathway?
- The combination of multiple receptor tyrosine kinase inhibitor and mammalian target of Rapamycin inhibitor overcomes erlotinib resistance in lung cancer cell lines …
- Experience with everolimus (RAD001), an oral mammalian target of Rapamycin inhibitor, in patients with systemic mastocytosis
- Antitumor efficacy profile of PKI-402, a dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor
- Rapamycin impairs trabecular bone acquisition from high‐dose but not low‐dose intermittent parathyroid hormone treatment
- Steady-state kinetic and inhibition studies of the mammalian target of Rapamycin (mTOR) kinase domain and mTOR complexes
- Rapamycin inhibits hepatectomy-induced stimulation of metastatic tumor growth by reduction of angiogenesis, microvascular blood perfusion, and tumor cell …
- Impact of mammalian target of Rapamycin inhibition on autosomal-dominant polycystic kidney disease
- Limited utility of Rapamycin in severe, refractory Wegener’s granulomatosis
- Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of Rapamycin/p70 S6 kinase (S6K1) pathway and serine …
- MYC activity mitigates response to Rapamycin in prostate cancer through 4EBP1-mediated inhibition of autophagy
- Target of Rapamycin in the oriental fruit fly Bactrocera dorsalis (hendel): its cloning and effect on yolk protein expression
- Rapamycin enhances aplaviroc anti-HIV activity: implications for the clinical development of novel CCR5 antagonists
- Reducing the risk of left ventricular hypertrophy in kidney transplant recipients: the potential role of mammalian target of Rapamycin
- Molecular pathways involved in hair follicle tumor formation: all about mammalian target of Rapamycin?
- Posttransplantation Therapeutic Rapamycin Concentration Protects Nitric Oxide–Related Vascular Endothelial Function: Comparative Effects in Rat Thoracic Aorta …
- Controversies in breast cancer: the mammalian target of Rapamycin as a target for breast cancer therapy
- WJD008, a dual phosphatidylinositol 3-kinase (PI3K)/mammalian target of Rapamycin inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed …
- AZD6244 (ARRY‐142886) enhances the antitumor activity of Rapamycin in mouse models of human hepatocellular carcinoma
- Increased frequency of regulatory T cells and selection of highly potent CD62L+ cells during treatment of human lung transplant recipients with Rapamycin
- Comparison of Rapamycin-and paclitaxel-eluting stents in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction
- Regulation of protein kinase Cδ downregulation by protein kinase Cε and mammalian target of Rapamycin complex 2
- Rapamycin reduces proteinuria and renal damage in the rat remnant kidney model
- How does the mammalian target of Rapamycin (mTOR) influence CD8 T-cell differentiation?
- Alteration of REDD1-mediated mammalian target of Rapamycin pathway and hypoxia-inducible factor-1α regulation in human breast cancer
- Immunohistochemical analysis of the mammalian target of Rapamycin signalling pathway in extramammary Paget’s disease
- Preventing restenosis after implantation of bare stents with oral Rapamycin: a randomized angiographic and intravascular ultrasound study with a 5-year clinical follow …
- Rapamycin can Inhibit the Development of Chlamydia pneumoniae, which Might Partly Contribute to the Prevention of In-stent Restenosis
- Depletion of mammalian target of Rapamycin (mTOR) via siRNA mediated knockdown leads to stabilization of β-catenin and elicits distinct features of …
- Indirect antitumor effects of mammalian target of Rapamycin inhibitors against Kaposi sarcoma in transplant patients
- … -pyrrolo [2, 3-b] pyridin-3-yl) methylene-4-hydroxybenzofuran-3 (2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of Rapamycin …
- Inhibitors of the mammalian target of Rapamycin and transplant tolerance
- Clinical implications of proteinuria in renal transplant recipients switching to Rapamycin for chronic allograft dysfunction
- Transforming growth factor beta 1 (TGF-β1) and Rapamycin synergize to effectively suppress human T cell responses via upregulation of FoxP3+ Tregs
- Descending serotonergic facilitation mediated by spinal 5-HT3 receptors engages spinal Rapamycin-sensitive pathways in the rat
- … replacement in 6-aryl-1H-pyrazolo [3, 4-d] pyrimidines and 2-arylthieno [3, 2-d] pyrimidines: ATP-competitive inhibitors of the mammalian target of Rapamycin (mTOR)
- Mycophenolate mofetil versus Rapamycin in Han: SPRD rats with polycystic kidney disease
- Rapamycin sensitizes Akt inhibition in malignant human breast epithelial cells
- Protection from Rapamycin-induced apoptosis by insulin-like growth factor-I is partially dependent on protein kinase C signaling
- Suppression of mTOR complex 2‐dependent AKT phosphorylation in melanoma cells by combined treatment with Rapamycin and LY294002
- Antitumour activity of a potent MEK inhibitor RDEA119/BAY 869766 combined with Rapamycin in human orthotopic primary pancreatic cancer xenografts
- Effects of delayed Rapamycin treatment on renal fibrosis and inflammation in experimental ischemia reperfusion injury
- Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of Rapamycin pathway in CD8+ T cells
- Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of Rapamycin–dependent endometrial hyperplasia and carcinoma
- Rapamycin inhibits yeast nucleotide excision repair independently of Tor kinases
- ID2‐VEGF‐related Pathways in the Pathogenesis of Kaposi’s Sarcoma: A Link Disrupted by Rapamycin
- Phosphorylation of translation factors in response to anoxia in turtles, Trachemys scripta elegans: role of the AMP-activated protein kinase and target of Rapamycin …
- Novel mechanism of Rapamycin in GVHD: increase in interstitial regulatory T cells
- Low-dose calcineurin inhibitor regimen combined with mammalian target of Rapamycin inhibitors preserves kidney functions in renal transplant recipients without …
- Rapamycin for chemoprevention of upper aerodigestive tract cancers
- Mutation of a phosphorylatable residue in Put3p affects the magnitude of Rapamycin-induced PUT1 activation in a Gat1p-dependent manner
- Spreading of mesothelioma cells is Rapamycin‐sensitive and requires continuing translation
- Rapamycin enhances platelet aggregation induced by adenosine diphosphate in vitro
- Insulin resistance without elevated mammalian target of Rapamycin complex 1 activity in muscles of mice fed a high-fat diet
- 4-Substituted-7-azaindoles bearing a ureidobenzofuranone moiety as potent and selective, ATP-competitive inhibitors of the mammalian target of Rapamycin (mTOR)
- Serine 2481-autophosphorylation of mammalian target of Rapamycin (mTOR) couples with chromosome condensation and segregation during mitosis: Confocal …
- Mammalian target of Rapamycin inhibition prevents glomerular hypertrophy in a model of renal mass reduction
- Select nutrients in the ovine uterine lumen. VI. Expression of FK506-binding protein 12-Rapamycin complex-associated protein 1 (FRAP1) and regulators and effectors …
- The effect of Rapamycin liposome gutta inhibiting rat corneal neovascularization
- Retracted: CCR5 blockade in combination with Rapamycin prolongs cardiac allograft survival in mice
- Rapamycin joins the aging fray: maybe Ponce de Leon visited Rapa Nui, not Florida
- Adenovirus-mediated eukaryotic initiation factor 4E binding protein-1 in combination with Rapamycin inhibits tumor growth of pancreatic ductal adenocarcinoma in vivo
- Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with Rapamycin
- Rapamycin does not adversely affect intrahepatic islet engraftment in mice and improves early islet engraftment in humans
- Late conversion to mammalian target of Rapamycin inhibitor/proliferation signal inhibitors in kidney transplant patients: clinical experience in the last 5 years
- … between a prospective randomised multicentre cutting balloon angioplasty and bare metal stent trial (REDUCE III) and the Rapamycin-Eluting Stent Evaluation At …
- … growth inhibition is augmented by synchronous inhibition of the insulin-like growth factor-1 receptor by NVP-AEW541 and inhibition of mammalian target of Rapamycin …
- Rapamycin suppresses the expansion and differentiation of porcine neonatal pancreas cell clusters
- The possible cellular mechanism for extending lifespan of mice with Rapamycin
- Rapamycin reduces kidney volume and delays the loss of renal function in a patient with autosomal-dominant polycystic kidney disease
- … posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3β and mammalian target of Rapamycin in adrenal chromaffin …
- Preparation of electrospun poly (L-lactide-co-caprolactone-co-glycolide)/phospholipid polymer/Rapamycin blended fibers for vascular application
- Combined effect of Rapamycin and cisplatin on survival of Hep-2 cells in vitro
- Adenosine-triphosphate promoting repair of spinal cord injury by activating mammalian target of Rapamycin/signal transducers and activators of transcription 3 signal …
- Mammalian target of Rapamycin complex 1 signaling opposes the effects of anchorage loss, leading to activation of Cdk4 and Cdc6 stabilization
- Rapamycin for Kaposi’s sarcoma and graft-versus-host disease in bone marrow transplant recipient
- Rapamycin instead of mycophenolate mofetil or azathioprine in treatment of post-renal transplantation urothelial carcinoma
- First-in-man use of polymer-free valsartan-eluting stents in small coronary vessels: a comparison to polymer-free Rapamycin (2%)-eluting stents
- Mammalian target of Rapamycin and autosomal dominant polycystic kidney disease
- Rapamycin-induced proteinuria following allogeneic hematopoietic stem cell transplantation
- Effect of Rapamycin on leukemia cell lines
- inhibition of IGF-I receptor signaling in combination with Rapamycin or temsirolimus increases MYC-N phosphorylation
- Role of GLUT1 in the Mammalian Target of Rapamycin Pathway: Mechanisms of Regulation.
- Exendin-4 protects pancreatic beta cells from the cytotoxic effect of Rapamycin by inhibiting JNK and p38 phosphorylation
- inhibition of mammalian target of Rapamycin (mTOR) in advanced pancreatic cancer: The results of two prospective phase II studies
- Monitoring Molecular-Specific Pharmacodynamics of Rapamycin In vivo with Inducible Gal4→ Fluc Transgenic Reporter Mice
- Combination of tipifarnib and Rapamycin synergistically inhibits the growth of leukemia cells and overcomes resistance to tipifarnib via alteration of cellular signaling …
- Pretreatment with intraluminal Rapamycin nanoparticle perfusion inhibits neointimal hyperplasia in a rabbit vein graft model
- Rapamycin prevents Concanavalin A‐induced liver injury by inhibiting lymphocyte activation
- Treatment algorithms in metastatic renal cell carcinoma, including the potential role of the novel oral mammalian target of Rapamycin inhibitor Everolimus
- Cyclooxygenase 2 mediates the antiangiogenic effect of Rapamycin in Ewing sarcoma
- Rapamycin selectively reduces the association of transcripts containing complex 5′ UTRs with ribosomes in C4‐2B prostate cancer cells
- Regioselective lipase-catalyzed acylation of 41-desmethoxy-Rapamycin without vinyl esters
- Rapamycin inhibits poly (ADP-ribosyl) ation in intact cells
- Early loss of mammalian target of Rapamycin complex 1 (mTORC1) signalling and reduction in cell size during dominant-negative suppression of hepatic …
- Combination Regimens of nab-Rapamycin (ABI-009) Effective Against MDA-MB-231 Breast-Tumor Xenografts.
- Rapamycin Inhibits Activator Protein-1 But Not Nuclear Factor-κB Activity of Mature Bone Marrow-Derived Dendritic Cells
- Autosomal dominant polycystic kidney disease (ADPKD): Rapamycin as a new treatment option
- Synthesis of the northern sector (C8–C19) of Rapamycin via Chan rearrangement and oxidation of an α-acyloxyacetate
- Rapamycin and thalidomide treatment of a patient with refractory metastatic gastroesophageal adenocarcinoma: a case report
- Effects of Rapamycin on Breast Cancer Cell Migration through the Cross-Talk of MAPK Pathway.
- inhibition of mammalian target of Rapamycin: the janus face of immunosuppression?
- Effect of Rapamycin on proliferated human umbilical vein endothelial cell
- … 5‐(2‐chloroethyl)‐2‐acetoxy‐benzyl]‐4‐(2‐chloroethyl)‐phenyl acetate inhibits phosphoinositide 3‐kinase/Akt/mammalian target of Rapamycin signalling through JNK …
- Progression of graft fibrosis under mammalian target of Rapamycin inhibitor‐based regimen
- Effects of Rapamycin on the differentiation and function of macrophages in vitro
- Monotherapy Rapamycin in renal transplant recipients with lymphoma successfully treated with rituximab
- Rapamycin enhances lipopolysaccharide-induced apoptosis and lung injury
- Rapamycin treatment suppresses epileptogenic activity in conditional Pten knockout mice
- Influence of Rapamycin on autophagy and apoptosis of two lepidoptera cell lines.
- Effect of Rapamycin on proliferation of acute myeloid leukemia cell lines HL-60 and HL-60/VCR
- A phase II trial of a mammalian target of Rapamycin inhibitor, temsirolimus, in patients with metastatic breast cancer.
- Molecular pathways in metastatic renal cell carcinoma: the evolving role of mammalian target of Rapamycin inhibitors
- Anti-insulin-like growth factor-1 receptor (IGF-IR) monoclonal antibody cixutumumab plus mammalian target of Rapamycin (mTOR) inhibitor temsirolimus in metastatic …
- Effect of Rapamycin and Cyclosporin A on the expression of TLR5 and Foxp3 in allorejection
- Combination therapy of 5-fluorouracil with Rapamycin for hormone receptor-negative human breast cancer
- … of D-cyclin translation inhibition in myeloma cells treated with mTOR inhibitors: rationale for combined treatment with ERK inhibitors and Rapamycin
- Dual inhibition of Akt/mTOR pathway by nab-Rapamycin and perifosine induces anti-tumor activity in multiple myeloma
- Forever young, slim and fit: Rapamycin to the rescue
- Evaluation of a Rapamycin‐regulated serotype 2 adeno‐associated viral vector in macaque parotid glands
- Recent developments of Rapamycin analogues
- Combination of Rapamycin and IL-2 do not affect antigen presentation ability of rat B cell and could promote Tregs proliferation and inhibitory activity
- Mammalian target of Rapamycin: MasTOR mediator of cellular changes in pathological states?
- Use of a cocktail regimen consisting of soluble galectin-1, Rapamycin and histone deacetylase inhibitor may effectively prevent type 1 diabetes
- Identification of Akt-selective cytotoxic compounds that enhance cytotoxic responses to Rapamycin
- Mammalian target of Rapamycin, Akt, and phosphatidylinositol 3-kinase signaling
- Prevention of hepatic tumor growth and metastasis in rats with Rapamycin
- Effect of Rapamycin on apoptosis in human myelodysplastic syndrome cell line MUTZ-1 and its possible mechanisms
- A phase I dose-finding and pharmacodynamic study of Rapamycin in combination with bevacizumab in patients with unresectable hepatocellular carcinoma.
- Antitumor activity, and antiangiogenic activity of nanoparticle albumin-bound nab-Rapamycin in combination with nab-paclitaxel.
- Mammalian target of Rapamycin (mTOR)-induced pneumonitis: Single-institution experience and treatment.
- inhibition of cell growth by Rapamycin through targeting mammalian target of Rapamycin signaling pathway in nasopharyngeal carcinoma
- Study advance of Rapamycin in the field of transplantation immunology [J]
- Release test of Rapamycin in drug-eluting stents
- The mechanism and influence of Rapamycin on proliferation of NIH3T3 fibroblasts transfected with mTOR gene [J]
- Effects of Rapamycin on angiogenesis and tumor progression in human hepatocellular carcinoma implantation mice
- Correlation factors of vascular restenosis and safety following Rapamycin drug-eluting stent implantation
- Mammalian target of Rapamycin, its mode of action and clinical response in metastatic clear cell carcinoma
- Regulation of bone formation using Rapamycin-induced BMP2 expression system: influence of implanted cell number
- Active-site inhibitors of mTOR target Rapamycin-resistant outputs of mTORC1 and mTORC2, PLoS Biol
- Effect of Rapamycin on proliferation, apoptosis and regulation of chemokine receptor CXCR4 in RPMI8226 cells
- Abstract C62: Identification of GSK2126458, a highly potent inhibitor of phosphoinositide 3‐kinase (PI3K) and the mammalian target of Rapamycin (mTOR)
- Rapamycin and HIV Replication in Liver Transplant Recipients
- Effects of Rapamycin-loaded poly (lactic-co-glycolic) acid nanoparticles on distribution of cell cycle, expression of p27 protein, and proliferation of human umbilical …
- Rapamycin induces apoptosis of lung adenocarcinoma cell A549 under hypoxia and its molecular mechanism
- A phase I study of sirolimus (Rapamycin) and bevacizumab in patients with advanced malignancies.
- Effects of Rapamycin on collagen type Ⅰ expression in rat myocardial cell induced by CVB 3
- Abstract C65: Enhanced antitumor effect by the combination of a PI3K inhibitor ZSTK474 with an mTOR inhibitor Rapamycin
- A stimulating new role for Rapamycin
- Synergistic augmentation of cisplatin-induced apoptosis in HeLa cells by Rapamycin
- Evaluation for synergistic suppression of breast cancer proliferation by Chloroquine in combination with the Rapamycin derivative, Rad001
- Rapamycin enhances lifespan: At last, an advantage for transplant recipients?
- Rapamycin reverses glucocorticoid resistance in human T-cell acute lymphoblastic leukemia CEM-C1 cells [J]
- Effects of Rapamycin on nephropathy of diabetic rats and expressions of vascular endothelial growth factor and its receptor [J]
- Interference of mTOR expression enhances sensitivity of esophageal squamous cell carcinoma EC9706 cells to Rapamycin
- Can phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibition ERase them all?
- Tuberous Sclerosis Complex and the Mammalian Target of Rapamycin Pathways
- Comparison of the MEIA and HPLC assays for the measurement of Rapamycin concentration in blood of recipients after renal transplantation [J]
- Effects of simvastatin on Rapamycin-treated cardiac microvascular endothelial cells
- Combined Rapamycin eye drop in nanometer vector and poly (lactic acid) wafers of cyclosporine A effectively prevents high-risk corneal allograft rejection in rabbits
- Mammalian target of Rapamycin inhibitors in the treatment of malignancy after organ transplantation
- Target of Rapamycin modulators of and use thereof
- Essential Role of Mammalian Target of Rapamycin (mTOR) in LH-dependent Testosterone Production in Rat Leydig Cells.
- Rapamycin inhibits growth and metastasis of gallbladder cancer GBC-SD cells.
- Pharmacological studies of a novel inhibitor of the mammalian target of Rapamycin (mTOR) signaling pathway
- Effects of Rapamycin on mTOR/p70S6K signaling pathway and tumor growth in xenografted esophageal squamous cell carcinoma.
- Effect of Rapamycin (serolimus) on in vitro cultured human keratinocytes
- Mesenchymal stem cells combined with Rapamycin immuno-regulates the spleniclymphocytes in allogenic mice.
- Effect of Rapamycin on the interaction between Salmonella typhi plasmid pR_ (ST98) and macrophages [J]
- Expression of JAK/STAT signal transduction pathway and the effects of Rapamycin in lupus nephritis-prone MRL/lpr mice
- CIRCULATING CD4CD25 HIGH CD127 LOW REGULATORY T-CELLS AFTER INTRACORONARY IMPLANTATION OF Rapamycin-ELUTING STENTS: PP. 2.73
- Preparation and production efficiency of Rapamycin ointment
- The influence of coronary stenting with Rapamycin-eluting stents on the number of circulating CD4+ CD25high+ regulatory T-cells
- Effect of Rapamycin on Phenotype of Vascular Smooth Muscle Cell and Arterial Intimal Hyperplasia in Rat Cardiac Allograft
- Mammalian target of Rapamycin inhibitors in clinical practice: Case reports of everolimus in renal cell carcinoma
- Application of stereocontrolled aldol coupling to synthesis of segments of immunosuppressants FK-506 and Rapamycin
- Abstract C63: Biological characterization of GSK2126458, a novel and potent inhibitor of phosphoinositide 3‐kinase and the mammalian target of Rapamycin (mTOR)
- Current perspectives in metastatic renal cell carcinoma treatment: the role of mammalian target of Rapamycin (mTOR) inhibition
- Rapamycin decreases proinflammatory and profibrogenic gene expression in experimental NASH
- Expression of mammalian target of Rapamycin and eIF4E signal pathway in cerebral glioma and its clinical significance [J]
- Conditional protein stabilization via the small molecules Shld-1 and Rapamycin increases the signal-to-noise ratio with tet-inducible gene expression
- A case of Kaposi’s sarcoma in the Rapamycin era
- OSI-027, a potent and selective small molecule mTORC1/mTORC2 kinase Inhibitor is mechanistically distinct from Rapamycin
- eIF4E Expression Predicts Apoptosis in Response to Epidermal Growth Factor Receptor inhibition and Mammalian Target of Rapamycin inhibition in Triple Negative …
- Rapamycin and PD98059 collaborative inhibit mammalian target of Rapamycin pathway in the prevention and treatment of mouse colorectal cancer
- Effect of Rapamycin on the growth of hepatocellular carcinoma in nude mice
- Rapamycin-based GvHD prophylaxis after T-cell replete unmanipulated haploidentical peripheral stem cell transplantation for advanced leukaemias: preliminary …
- Effect of Rapamycin administration in humans on the skeletal muscle protein anabolic response to essential amino acid ingestion
- Differential Regulation of TLR4-Mediated TNF-a Release by Mammalian Target of Rapamycin and Glycogen Synthase Kinase-3 in Alveolar Macrophages from …
- A newly developed Rapamycin-eluting stent with a biodegradable polymer reduces neointimal formation while allowing greater endothelialization
- CONVERSION TO LOW DOSE TACROLIMUS OR Rapamycin 3 MONTHS AFTER KIDNEY TRANSPLANT: A PROSPECTIVE, PROTOCOL BIOPSY GUIDED STUDY …
- The Effect of Rapamycin on Cardiac Allograft Vasculopathy in Rats
- Abstract A94: effects of different modes of calorie restriction on mammalian target of Rapamycin (mTOR) and IGF-I signaling pathways in mammary fat pads and tumors
- Rapamycin-Based GvHD Prophylaxis Is Effective in T-Cell Replete Unmanipulated Haploidentical Peripheral Stem Cell Transplantation for Advanced Haematological …
- Role of Rapamycin in renal ischemia-reperfusion injury
- Symbol Domestic Rapamycin-eluted stent for treatment of acute myocardial infarction in 108 cases
- Rapamycin Used in Kidney Transplantation Patients in China: A Meta-analysis of Clinical Curative Effects
- Conversion to Rapamycin in liver transpant recipients with renal insufficiency
- Genomewide Profiling of Rapamycin Sensitivity in Saccharomyces cerevisiae on Synthetic Medium
- Effect of Rapamycin (serolimus) on in vitro cultured human oral mucosa keratinocytes
- Effects of Rapamycin and paclitaxel on different human prostate cancer cells and xenografts
- The Generation of Novel Fluorinated Rapamycin Analogues
- Treg and Rapamycin effects on humoral immunity in young and old mice (84.12)
- EXPERIENCE WITH Rapamycin IN PEDIATRIC LIVER TRANSPLANTATION: 1434
- Inhibitory effect of Rapamycin on proliferation of H_ (22) hepatic cancer in mice
- Effect of Rapamycin on Postoperative Fibrosis After Filtration Surgery in a Rabbit Model
- The mammalian target of Rapamycin in translation and folding
- Effect of Rapamycin on the proliferation and apoptosis of glomerular mesangial cells
- Transcriptional Profile Changes Induced by Rapamycin in Breast Cancer Maintained in Organ Culture.
- Ex Vivo Manufacture of Rapamycin-Resistant Human Th1/Tc1 Cells.
- Effect of Rapamycin on regulator T cells induced by TGF-β1 in vitro
- Study of long-term safety and efficacy of domestic Firebird Rapamycin-eluting stent
- The Role of Mammalian Target of Rapamycin in the Early Development of Mouse Zygotes
- Efficacy of Rapamycin drug-eluting stents in elderly patients with coronary heart disease
- Insights into hepatic carcinogenesis: The effect of Rapamycin on rat liver cell lines
- Rapamycin combined with cisplatin in inhibiting the proliferation of ovarian cancer SKOV-3 cells [J]
- Development of Selective Inhibitors of the Mammalian Target of Rapamycin
- Rapamycin is a potent inhibitor of skin tumor promotion by TPA
- Antiproliferative and antiangiogenic effect of Rapamycin on ADPKD cystic lining epithelial cells
- Abstract B141: Effects of AZD8055, a novel mTOR kinase inhibitor, in human cancer cells developing resistance to Rapamycin
- Abstract A41: Evaluation of maximum tolerated dose of aerosolized Rapamycin in A/J mice
- Rapamycin combined with nimuatine suppresses growth and proliferation of human U87MG glioma cells
- Effect of mTOR inhibition by Rapamycin on promotion of skin tumors in BK5. Aktwt transgenic mice
- Characterization of the Effects and Functions of Sumoylation Through Rapamycin-Mediated Heterodimerization
- Black and white: Rapamycin as a regulator of cardiac mTOR signaling
- Immunomodulatory Effect of Rapamycin on Innate Immune Response Genes
- Clenbuterol increases PGC1a promoter activity via a Rapamycin sensitive mechanism
- Active-Site inhibition of the Mammalian Target of Rapamycin
- Effect of Rapamycin on cell prolification of glomerular mesangial cells by high glucose
- The role of mammalian target of Rapamycin complex 1 in hepatic physiology and disease
- Anti-Leukemia Effect of Rapamycin Alone or Plus Daunorubicin on Acute Lymphoblastic Leukemia Cell Lines
- Rapamycin reduces primary effusion lymphoma progression by targeting VEGF production and VEGF responses
- A Combined Approach of Classical Mutagenesis and Rational Metabolic Engineering for the Improved Production of Rapamycin in Streptomyces hygroscopicus …
- Rapamycin-Induced Abundance Changes in the Proteome of Budding Yeast
- Inhibitory effect of Rapamycin on human renal tubular epithelial-myofibroblast transition
- Rapamycin sensitizes Jurkat T-ALL cells to dexamethasone-induced apoptosis
- Effects of Rapamycin on cell proliferation and apoptosis of melanoma B-16 cells
- The influence of Rapamycin combined with 5-Aza-cdR to interfere in the in vitro culture of MCF-7 cell line
- Mammalian Target of Rapamycin Signaling in Regulation of Aging of Human RPE
- The therapeutic value of Rapamycin in a novel mouse model for tuberous scelrosis
- Novel therapeutic strategy for breast cancer: mammalian target of Rapamycin inhibition
- Effects of Rapamycin on growth and mTOR/4EBP1 Signalling Pathway in Xenograft of Esophageal Squamous Cell Carcinoma
- Comparison of Rapamycin and Mitomycin for Reduction of Postoperative Fibrosis After Filtration Surgery in a Rabbit Model
- Rapamycin enhances G protein signaling in the budding yeast Saccharomyces Cerevisiae
- Pharmacokinetics characterization of Rapamycin ointment in rabbit aqueous humor
- Effects of Rapamycin on nephropathy and expression of VEGF and VEGF receptors in PAN nephritic mice [J]
- … Rapamycin Combination toward Colon Cancer Cells In vivo and In vitro Is Mediated through Cooperative Modulation of the MammalianTarget of Rapamycin …
- The Regulation of STAT1 Nuclear Content by Mammalian Target of Rapamycin
- Mammalian Target of Rapamycin Regulates STAT1 Localization in Lung Epithelial Cells.
- Rapamycin-Induced Allograft Tolerance: Elucidating Mechanisms and Biomarker Discovery
- Rapamycin prevents the post‐exercise increase in protein synthesis and alters cell signaling in human skeletal muscle
- The Rapamycin-sensitive phosphoproteome reveals that TOR controls PKA 3 toward some but not all substrates 4
- CLONING AND CHARACTERIZATION OF THE PARTIAL Rapamycin-BIOSYNTHETIC GENE CLUSTER FROM ACTINOPLANES SP. N902-109
- Expression of mammalian target of Rapamycin/P70S6K in pathologic scars
- Rapamycin‐sensitive Co‐localization of mTOR to the Mitotic Spindle
- Abstract B143: Distinct antitumor mechanisms of VEGFR inhibitor tivozanib (AV‐951) and mTOR inhibitor Rapamycin support rational combination for solid tumors to …
- Effectiveness of Rapamycin drug-eluting stent (Excel stent) in treatment of patients with coronary artery disease
- Defining the clinical role of the mammalian target of Rapamycin (mTOR) in lung cancer
- BETA-CATENIN TARGET GENES ARE UPREGULATED DURING PARTIAL BLADDER OUTLET OBSTRUCTION AND INHIBITED BY Rapamycin
- Effect of Rapamycin on TGF-β1-induced epithelial-mesenchymal transition in LoVo colonic adenocarcinoma cells
- Tolerability of the mTOR inhibitor Rapamycin in cirrhotic patients with advanced hepatocellular carcinoma
- Clinical Application of Domestic Rapamycin-Eluting Stent in the Emergency Intervention of Acute Coronary Syndrome (ACS)
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss
- Effect of Rapamycin on regulating Toll-like receptor-4 gene expression in rats with acute liver failure
- The influence of Rapamycin on expression of CCR7 in the rats with renal fibrosis induced by adriamycin
- Rapamycin induces proliferation of CD4~+ CD25~+ FoxP3~+ T regulatory cells in rats
- Mammalian target of Rapamycin complex 2 regulates helper T cell differentiation and function (47.31)
- BLADDER SMOOTH MUSCLE CELL GROWTH IS MEDIATED BY MAMMALIAN TARGET OF Rapamycin (mTOR)
- Expression and significance of phosphorylation-mammalian target of Rapamycin in endometrial carcinoma
- High Levels Of Mammalian Target Of Rapamycin (mTOR) In Pulmonary Hypertension
- Transscleral Passive Delivery of Rapamycin in Rabbit Using a Visulex® Topical Application Device
- Inhibitory effect of Rapamycin on connective tissue growth factor-stimulated cell proliferation and fibronectin secretion in myofibroblasts
- Treatment of malignant gliomas with systemic Rapamycin and convection-enhanced delivery of nanoliposomal CPT-11
- e0519 Rapamycin suppress KrÜppel-Like Factor 2 expression: mechanism of endothelial dysfunction associated with drug-eluting stents
- The mammalian target of Rapamycin inhibitor RAD001 (everolimus) in early breast cancer
- Mammalian target of Rapamycin inhibitors for the targeted therapy of non-small cell lung cancer
- Chronic Rapamycin Therapy Ameliorates Hypertrophy and Systolic Dysfunction in Severe Chronic Heart Failure Due to Pressure Overload
- Physiologic Stimulation Of Bladder Smooth Muscle Cell Growth Is Mediated By Mammalial Target Of Rapamycin (mTOR)
- Treatment of Non-left Main Bifurcation Lesions Using the Rapamycin-Eluting Stent
- Determination of Encapsulation Efficiency of Rapamycin-loaded Poly (lactic-co-glycolic) acid Nanoparticles by HPLC
- Elucidation of chemopreventive effects of aerosolized Rapamycin and dietary myoinositol by mechanistic biomarkers in mouse lung
- Expansion of CD3+/CD4+/CD25+/Foxp3+ T cells in Rapamycin-treated lupus patients (143.52)
- Mammalian target of Rapamycin (mTOR) inhibitors with therapeutic potential for colitis
- PATHOLOGICAL ANGIOGENESIS IN VASCULAR TUMORS IS DRIVEN BY AKT1 AND INHIBITED BY TOPICAL Rapamycin
- Combination Of Simvastatin And Rapamycin Abrogates TSC2-null Tumor Growth In Nude Mice And Improves Animal Survival
- Pathological angiogenesis in vascular tumors is driven by endothelial Akt1 and inhibited by Rapamycin
- Effect of intravenous injection of apoptotic cells combined with Rapamycin on regulatory T cells in rhesus monkey
- Rapamycin Inhibits Store-Operated Ca2+ Entry in Cells Isolated from Endarterectomized Tissues of Patients with Chronic Thromboembolic Pulmonary Hypertension.
- Immune regulatory effect of Rapamycin and cyclosporine A on experimental corneal allograft survival
- Effect of Rapamycin Eluting Stent for inhibition of Neointimal Hyperplasia in Diabetic Porcine Model
- Supplemental Information Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- Effects of high glucose and Rapamycin intervention on expression of type Ⅳ collagen and matrix metalloproteinase-9 in podocytes
- Cigarette Smoke And Rapamycin Up-regulate Matrix Metalloproteinase-1 Expression In Endothelial Cells Through mTOR Activation
- Preparation and in vitro release study of Rapamycin in poly (lactic-co-glycolic) acid microsphere for topical administration
- PDGFR alpha is overexpressed in synovial sarcomas and can mediate Rapamycin induced Akt activation
- Enhanced tumor cytotoxicity of a combinational therapy using liposomal copper-doxorubicin, Rapamycin, and ultrasound
- Rapamycin-CONDITIONED HUMAN DENDRITIC CELLS EXHIBIT INCREASED IL-12P70 PRODUCTION UPON EXPOSURE TO PRO-INFLAMMATORY …
- Rapamycin eye drops inhibit rat corneal neovascularization: Role of vascular endothelial growth factor and inflammatory factor☆
- The mammalian target of Rapamycin signaling pathway in bovine mammary epithelial cells
- Characterisation of the effects and mechanism of action of Rapamycin and genistein on acute myeloid leukemia using high-throughput techniques
- New Drug Development in Sarcoma: Exploration of Novel Targets, Particularly the Mammalian Target of Rapamycin (mTOR) Pathway
- 45A: TARGETED SITE SPECIFIC IMMUNOSUPPRESSION WITH TOPICAL Rapamycin AND MYCOPHENOLIC ACID IN COMPOSITE TISSUE …
- 1, 4-phenylenebis (methylene) selenocyanate (p-XSC) inhibits mammalian target of Rapamycin complex 2 (mTORC2) signaling in prostate cancer cells
- Pre-clinical and Clinical Study Results for the Coracto™ Rapamycin-eluting Stent–A New-generation Drug-eluting Stent
- The Protective Effect of mammalian Target of Rapamycin (mTOR) in Cisplatin Induced Nephropathy
- Contact-dependent suppression pathways in non-human primate Tregs expanded ex vivo in the presence of Rapamycin (141.36)
- The effects of l-leucine, contractions, and Rapamycin on the Akt/mTOR pathway in rat skeletal muscle
- Rapamycin IMPAIRS PROLIFERATION OF TRANSPLANTED ISLET BETA CELLS: 791
- Rapamycin inhibits epidermal cell proliferation in a xenograft model of tuberous sclerosis skin tumors
- Effect of the combination of retinoic acid and Rapamycin on cerebellar granule cell and medulloblastoma proliferation
- Nutrient signaling, mammalian target of Rapamycin and ovine conceptus development
- Effect of combination of CCR5 antisense peptide nucleic acid and lose-dose Rapamycin on islet allograft survival
- Rapamycin inhibits cyst growth, IGF-1-mediated VEGF secretion and cell proliferation in polycystin-2 defective mice
- Is Oral Rapamycin Plus Bare Metal Stents a Feasible Alternative to Drug‐Eluting Stents? Lessons Learned from Argentina Observational and Randomized Studies …
- Rapamycin-Induced Autophagy Generates Anti-Apoptotic Th1/Tc1 Cells That Mediate Increased Xenogeneic Gvhd.
- Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism in the Krebs cycle
- Combination of antagonists of growth hormone-releasing hormone antagonist (GHRH) with Rapamycin as a potential therapy in human breast cancers.
- Role of mammalian target of Rapamycin signalling in bone destruction by gingival squamous cell carcinoma
- Rapamycin potentiates the effects of paclitaxel in uterine papillary serous carcinoma (UPSC) cells through inhibition of cell proliferation and induction of apoptosis
- Symbol Effect of Rapamycin-poly (lactide-acid)/magnetic microsphere composite materials on the proliferation of vascular smooth muscle cells
- Retinoblastoma Tumor Burden Control: Periocular m-TOR Inhibitor Rapamycin Decreases Tumor Burden in Advanced LHBETATAG Murine Retinoblastoma
- Effects of Mycophenolic Acid and Rapamycin on Toll-like Receptor Expression in Hypoxic Human Proximal Tubular Epithelial Cells
- The Impact of Iron Deficiency During Development on Mammalian Target of Rapamycin Signaling, Neuronal Structure, and Learning and Memory Behavior
- Mammalian Target of Rapamycin: A Bump in the Pathway to NF-κB Activation and ICAM-1 Expression in Endothelial Cells.
- Increased Frequency Of Regulatory T-Cells And Selection Of Highly Potent CD62L+ Cells During Treatment Of Human Lung Recipients With Rapamycin
- The IGF-1 receptor targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with Rapamycin in models of childhood sarcoma
- Targeting mammalian target of Rapamycin (mTOR) signaling in the Han: SPRD rat, a model for polycystic kidney disease
- Chemical Genetic Dissection of TOR Signaling Through Identification and Characterization of Small Molecule Enhancers of Rapamycin
- Mammalian Target of Rapamycin Signaling and the Suprachiasmatic Circadian Clock
- Abstract# 3712: OXA-01, a novel potent mTORC1/TORC2 inhibitor displays improved anti-tumor activity in comparison to Rapamycin, an mTORC1 selective inhibitor
- inhibition of mammalian target of Rapamycin induces phenotypic reversion in three-dimensional cultures of malignant breast epithelial cells
- Rapamycin mediated inhibition of mTOR prevents postprandial activation of the unfolded protein response and upregulation of fatty acid synthase
- Distinct phosphatase requirements and GATA factor responses to nitrogen catabolite repression and Rapamycin treatment in S. cerevisiae
- Use of Rapamycin Reveals Evidence of the Physiological Roles of FKBP12 and FKBP12. 6 In Cardiac Excitation-Contraction Coupling
- e0520 Statin effects in stent thrombosis induced by Rapamycin releasing from drug-eluting stents through KrÜppel-Like Factor 2 overexpression
- Rapamycin enhanced in vitro and in vivo activity of dexamethasone against acute lymphoblastic leukemia and lymphoma preclincal models via inhibition of p70S6 …
- Human T Cell Rapamycin Resistance And Th1/Tc1 Polarization Augment Xenogeneic Graft-Versus-Host Disease
- Abstract# 4363: inhibition of mammalian target of Rapamycin (mTOR) in advanced pancreatic cancer-the results of two prospective phase II studies.
- In vitro enhancing oxidative phosphorylation by Rapamycin in proliferative CD8+ T cells during antigenic priming augments the generation of long-lived memory T cells …
- Comparasion of therapeutic effects of Chinese Rapamycin-eluting stent and imported paclitaxel-eluting stent in treatment of acute myocardial infarction
- Generation of tolerogenic human DC through Rapamycin conditioning and genetic modification with HLA-G.
- Prolonged Exposure of Myeloid Dendritic Cells To Rapamycin enhances LPS-induced IL-12p70 production, but does not promote Th1 responses (141.29)
- The mammalian target of Rapamycin mediates the angiogenic and chemotactic effects of leptin in human hepatic stellate cells.
- Calorie restriction and Rapamycin, but not exercise, inhibit MMTV-Wnt-1 mammary tumor growth in a mouse model of postmenopausal obesity
- Abstract# LB-135: Grapefruit juice significantly increases bioavailability of weekly Rapamycin (sirolimus)-evidence of safety and activity in a phase 1 study
- Mammalian Target of Rapamycin (mTOR)-mediated Effect on Disease Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
- Vitamin K_3 induces autophagy in HeLa cells through downregulating the mammalian target of Rapamycin (mTOR) pathway
- Pharmacodynamic (PD) study of pre-prostatectomy Rapamycin in men with advanced localized prostate cancer (PC): A DOD Prostate Cancer Clinical Trials …
- Effects of high-fat vs. low-fat diets on mammalian target of Rapamycin signaling and metabolic measures in spontaneously hypertensive rats
- Anti-liver fibrotic effect of Salvia miltiorthiza and Shugan-Huayu powder combining with or without Rapamycin in animal models.
- Rapidly Inducible Protein Modification Using Rapamycin-mediated Complementation Of Tobacco Etch Virus (TEV) Protease
- Modulatory Role of Mammalian Target of Rapamycin in Regulating Endothelial ICAM‐1 Expression and Lung PMN Recruitment
- Erratum: Mammalian target of Rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial …
- Rapamycin AND MYCOPHENOLIC ACID, BUT NOT CYCLOSPORIN A, IMPAIR HUMAN NK CELL CYTOLYTIC ACTIVITY DUE TO DIFFERENTIAL EFFECTS ON …
- 198 Modulation of CCR5 density with low doses of the transplant drug Rapamycin sensitizes Vicriviroc-resistant R5 HIV-1
- Rapamycin and IL-2 Prevents Lethal Acute Graft-Versus Host Disease by Expansion of Donor Type CD4+CD25+Foxp3+ Regulatory T Cells.
- Abstract# 4648: Rapamycin inhibits tube formation of lymphatic endothelial cells by targeting TORC1-mediated expression of Flt4
- Abstract LB-74: A high-throughput RNAi sensitization screen of Rapamycin identifies targets for rational drug combination strategies
- Abstract# 2770: Over-expression of the mammalian target of Rapamycin (mTOR): a novel biomarker for poor survival in resected early stage non-small cell lung cancer
- Abstract# 2014: ATP competitive inhibitors of the mammalian target of Rapamycin (mTOR): Design and synthesis of novel, highly selective pyrazolopyrimidines with …
- The Mammalian Target of Rapamycin (mTOR) Is a Novel Regulator of HMW-Hyaluronan-Mediated Pulmonary Endothelial Barrier Enhancement.
- COMBINED ADMINISTRATION OF A NOVEL MUTANT TGF-β1/FC AND Rapamycin MODULATES THE IMMUNE BALANCE BETWEEN TREG AND TH17 AND …
- CD28: FC AND Rapamycin CAN PREVENT TH17-MEDIATED ALLOGRAFT REJECTION IN MOUSE PANCREATIC ISLET TRANSPLANTATION MODEL: 700
- Androgen receptor antagonist bicalutamide sensitizes androgen-independent prostate cancer cells to mTOR inhibitor Rapamycin by regulating phosphorylation of …
- Abstract# 1735: Rapamycin inhibits hyperactivation of mTORC1 signaling in a novel xenograft model of tuberous sclerosis complex skin tumors
- ET-29. ONCOLYTIC VIRUS COMBINED WITH Rapamycin TARGETING BRAIN TUMOR-INITIATING CELLS
- … Multicenter phase I clinical trial of an insulin like growth factor (IGF‐R) inhibitor (IMC‐A12) in combination with a mammalian target of Rapamycin (mTOR) inhibitor (CCI …
- Mouse Oocytes Promote the Mechanistic Target of Rapamycin (Serine/Threonine Kinase, mTOR) Pathway in Cumulus Cells by Suppressing the Expression of DNA …
- … oral protein: time‐dependent concordance/discordance between muscle protein synthesis (MPS) and mammalian target of Rapamycin (mTOR)‐associated signaling
- Relationship between expression of mutant type glutathione S-transferase theta-1 gene and reactivity of Rapamycin in myelodysplastic syndrome
- Rapamycin CONDITIONED DENDRITIC CELLS FOR IN VITRO DIFFERENTIATION OF DONOR-SPECIFIC CD4+ CD25+ FOXP3+ REGULATORY T CELLS FOR …
- … DEVELOPMENT OF CD8+ CD44+ CD62L+ MEMORY T CELLS PROMOTE SPECIFIC TOLERANCE TO CARDIAC ALLOGRAFTS FOLLOWING Rapamycin …
- Abstract# 4050: Increased cytotoxicity with nifurtimox and Rapamycin combination therapy in neuroblastoma.
- The Effect of Insulin-like Growth Factor 1 (IGF-1) and Exercise on the Protein Expression of Mammalian Target of Rapamycin (mTOR) and Androgen Receptor (AR) in …
- Abstract# 3711: Superior cellular anti-tumor effects of a dual mTORC1/mTORC2 kinase inhibitor OXA-01 relative to the mTORC1 inhibitor Rapamycin
- Erratum 2: Testosterone induces cardiomyocyte hypertrophy through mammalian target of Rapamycin complex 1 pathway
- Erratum 2: Testosterone induces cardiomyocyte hypertrophy through mammalian target of Rapamycin complex 1 pathway (vol 202, pg 299, 2009)
- Abstract# 156: Is irinotecan and Rapamycin combination, targeting mTOR/HIF-1 alpha axis, a new effective therapy in high grade brain tumors?
- Intra-Nuclear Function for PP2A Phosphatase: Pph21/22 Are Required for Rapamycin-Induced GATA Factor Binding to the DAL5 Promoter in Yeast
- Activating transcription factor 4 negatively regulates the mammalian target of Rapamycin via Redd1 expression in response to 2-deoxyglucose
- Abstract# 5237: The combination of Rapamycin and bicalutamide induce apoptosis in prostate cancer cells by simultaneously inhibiting the mTORC1/eIF4 and AR …
- TORC1/2 inhibitors have more potent anti-leukemic efficacy and are less immunosuppressive than Rapamycin
- Abstract# 2824: The Src inhibitor AZD0530 enhances the anti-tumor effect of Rapamycin in hepatocellular carcinoma (HCC) cells
- Abstract LB-159: An orthotopic model of head and neck squamous carcinoma reveals that mTOR inhibition with Rapamycin halts lymph node metastasis
- Abstract# 3842: High expression of mTOR (mammalian target of Rapamycin) is associated with better outcome in non-small cell lung cancer
- Abstract# 1079: CD133 expression is affected by Rapamycin in cancer cells.
- Abstract# 2879: inhibition of mammalian target of Rapamycin as a therapeutic strategy in the management of bladder cancer
- Abstract# 3757: Antiproliferative effects of Rapamycin and doxorubicin combination on human Erbb2 overexpressing breast epithelial cell lines.
- Abstract# 2818: Growth inhibition of human breast cancer cells with an iron chelator and a dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor
- Abstract# 2302: NVP-BEZ235 a dual inhibitor of phosphatidylinositol 3-Kinase (PI3 Kinase) and mammalian target of Rapamycin (mTOR) potently enhances the effects …
- Liposomal KRN7000 (RGI-2001) Synergizes with Low-Dose Rapamycin in Preventing GvHD by promoting expansion of naturally-Occurring CD4+FOXP3+ …
- Abstract P3-14-17: Trastuzumab (H) and Rapamycin (R) for Treatment of HER-2 Overexpressing Metastatic Breast Cancer (BC) with Prior Disease Progression on H …
- … : HQO-0601, an amide-containing 3, 4-dihydroquinolinone derivative, against human hematologic malignancies through inhibition of mammalian target of Rapamycin …
- Rapamycin slows aging in mice
- Fighting neurodegeneration with Rapamycin: mechanistic insights
- Target of Rapamycin (TOR) in nutrient signaling and growth control
- Rapamycin and glucose-target of Rapamycin (TOR) protein signaling in plants
- Rapamycin passes the torch: a new generation of mTOR inhibitors
- Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
- Autophagy activation by Rapamycin reduces severity of experimental osteoarthritis
- Protein translocation as a tool: The current Rapamycin story
- Relieving autophagy and 4EBP1 from Rapamycin resistance
- Chronic inhibition of mammalian target of Rapamycin by Rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
- Paradoxical aspects of Rapamycin immunobiology in transplantation
- Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer
- Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
- TOR signaling and Rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
- Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders
- The mammalian target of Rapamycin regulates cholesterol biosynthetic gene expression and exhibits a Rapamycin-resistant transcriptional profile
- A photocleavable Rapamycin conjugate for spatiotemporal control of small GTPase activity
- Target of Rapamycin signaling regulates metabolism, growth, and life span in Arabidopsis
- Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
- Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex
- Rapamycin and other longevity‐promoting compounds enhance the generation of mouse induced pluripotent stem cells
- mTOR and Rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression
- Inducing autophagy by Rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits
- … enhances the anti-tumor activity of the mTOR inhibitor Rapamycin in multiple breast cancer cell lines mainly by suppressing Rapamycin-induced AKT signaling
- Common toxicities of mammalian target of Rapamycin inhibitors
- Topical Rapamycin therapy to alleviate the cutaneous manifestations of tuberous sclerosis complex
- Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
- Activating mutations of TOR (target of Rapamycin)
- Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells
- Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function
- Mammalian target of Rapamycin: a signaling kinase for every aspect of cellular life
- Mammalian target of Rapamycin: a central node of complex signaling cascades
- Induction of tolerance to factor VIII by transient co‐administration with Rapamycin
- Once again on Rapamycin-induced insulin resistance and longevity: despite of or owing to
- Haploinsufficiency of target of Rapamycin attenuates cardiomyopathies in adult zebrafish
- Stability of human Rapamycin-expanded CD4+ CD25+ T regulatory cells
- Autophagy and cardiovascular aging: lesson learned from Rapamycin
- Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice
- A pulse Rapamycin therapy for infantile spasms and associated cognitive decline
- Hyperplexing: a method for higher-order multiplexed quantitative proteomics provides a map of the dynamic response to Rapamycin in yeast
- Rapamycin protects against myocardial ischemia–reperfusion injury through JAK2–STAT3 signaling pathway
- Mammalian target of Rapamycin and the kidney. I. The signaling pathway
- The ketogenic diet inhibits the mammalian target of Rapamycin (mTOR) pathway
- Preventive and therapeutic effects of Rapamycin, a mammalian target of Rapamycin inhibitor, on food allergy in mice
- Shedding new light on neurodegenerative diseases through the mammalian target of Rapamycin
- Lifelong Rapamycin administration ameliorates age‐dependent cognitive deficits by reducing IL‐1β and enhancing NMDA signaling
- Mammalian target of Rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
- Mammalian target of Rapamycin signaling in diabetic cardiovascular disease
- Rapamycin promotes autophagy and reduces neural tissue damage and locomotor impairment after spinal cord injury in mice
- Folate-conjugated Rapamycin slows progression of polycystic kidney disease
- Mammalian target of Rapamycin (mTOR) signaling network in skeletal myogenesis
- Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy
- Chronic mTOR inhibition by Rapamycin induces muscle insulin resistance despite weight loss in rats
- Wound healing complications and the use of mammalian target of Rapamycin inhibitors in kidney transplantation: a critical review of the literature
- Rapamycin increases oxidative stress response gene expression in adult stem cells
- inhibition of mammalian target of Rapamycin reduces epileptogenesis and blood–brain barrier leakage but not microglia activation
- Rapamycin As an Antiaging Therapeutic?: Targeting Mammalian Target of Rapamycin to Treat Hutchinson–Gilford Progeria and Neurodegenerative Diseases
- Successful treatment of angiofibromata of tuberous sclerosis complex with Rapamycin
- Rapamycin protects against middle cerebral artery occlusion induced focal cerebral ischemia in rats
- Rapamycin Causes Upregulation of Autophagy and Impairs Islets Function Both In Vitro and In Vivo
- Therapeutic role of mammalian target of Rapamycin (mTOR) inhibition in preventing epileptogenesis
- Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose Rapamycin impairs autophagic flux in …
- Prevention of age-related macular degeneration–like retinopathy by Rapamycin in Rats
- Mammalian target of Rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer’s disease?
- The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of Rapamycin (mTOR) pathway
- Current and future directions in mammalian target of Rapamycin inhibitors development
- Gli inhibitor GANT61 causes apoptosis in myeloid leukemia cells and acts in synergy with Rapamycin
- Target of Rapamycin regulates development and ribosomal RNA expression through kinase domain in Arabidopsis
- Mammalian target of Rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids
- The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by Rapamycin
- inhibition of mammalian target of Rapamycin augments lipopolysaccharide-induced lung injury and apoptosis
- New nanoformulation of Rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis
- Combinatorial effects of lapatinib and Rapamycin in triple-negative breast cancer cells
- Phase II study of the mammalian target of Rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas
- Impaired autophagy in neurons after disinhibition of mammalian target of Rapamycin and its contribution to epileptogenesis
- Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann–Sträussler–Scheinker disease
- Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of Rapamycin (mTOR) complex 2
- Rapamycin reverses elevated mTORC1 signaling in lamin A/C–deficient mice, rescues cardiac and skeletal muscle function, and extends survival
- Retinoic acid and Rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells
- Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae
- Review of cytomegalovirus infection findings with mammalian target of Rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients
- Low‐Dose Rapamycin Treatment Increases the Ability of Human Regulatory T Cells to Inhibit Transplant Arteriosclerosis In Vivo
- Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of Rapamycin on protein synthesis
- Managing stomatitis in patients treated with Mammalian target of Rapamycin inhibitors.
- Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation
- Rapamycin blocks production of KSHV/HHV8: insights into the anti-tumor activity of an immunosuppressant drug
- inhibition of mechanistic target of Rapamycin promotes dendritic cell activation and enhances therapeutic autologous vaccination in mice
- Therapeutic value of prenatal Rapamycin treatment in a mouse brain model of tuberous sclerosis complex
- Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
- Rapamycin slows aging in mice
- Amino acids activate mammalian target of Rapamycin complex 2 (mTORC2) via PI3K/Akt signaling
- Suppression of replicative senescence by Rapamycin in rodent embryonic cells
- inhibition of the mammalian target of Rapamycin blocks epilepsy progression in NS‐Pten conditional knockout mice
- The mTOR inhibitor Rapamycin suppresses DNA double-strand break repair
- Autophagy stimulation by Rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis
- Rapamycin for treatment of type I autosomal dominant polycystic kidney disease (RAPYD-study): a randomized, controlled study
- Differing effects of Rapamycin or calcineurin inhibitor on T‐regulatory cells in pediatric liver and kidney transplant recipients
- Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by Rapamycin
- Post-treatment with Rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy
- Mammalian target of Rapamycin and the kidney. II. Pathophysiology and therapeutic implications
- Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF
- Optimization of Rapamycin-loaded acetalated dextran microparticles for immunosuppression
- Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity
- Mammalian target of Rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α
- Stress-responsive sestrins link p53 with redox regulation and mammalian target of Rapamycin signaling
- Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons
- Oral Rapamycin in the treatment of patients with hamartoma syndromes and PTEN mutation
- Oral adverse events associated with tyrosine kinase and mammalian target of Rapamycin inhibitors in renal cell carcinoma: a structured literature review
- Efficacy and safety of sorafenib in combination with mammalian target of Rapamycin inhibitors for recurrent hepatocellular carcinoma after liver transplantation
- Involvement of the mammalian target of Rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists
- N‐acetylcysteine reduces disease activity by blocking mammalian target of Rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double …
- … lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of Rapamycin
- Antitumor activity of Triolimus: a novel multidrug-loaded micelle containing Paclitaxel, Rapamycin, and 17-AAG
- Rapamycin-induced glucose intolerance: hunger or starvation diabetes
- Induction of biogenic magnetization and redox control by a component of the target of Rapamycin complex 1 signaling pathway
- Rapamycin resistance is linked to defective regulation of Skp2
- Rapamycin ameliorates kidney fibrosis by inhibiting the activation of mTOR signaling in interstitial macrophages and myofibroblasts
- Roles of the mammalian target of Rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis
- The mTOR inhibitor Rapamycin has limited acute anticonvulsant effects in mice
- Multiple roles for mammalian target of Rapamycin signaling in both glutamatergic and GABAergic synaptic transmission
- Rapamycin suppresses self-renewal and vasculogenic potential of stem cells isolated from infantile hemangioma
- Rapamycin-induced enhancement of vaccine efficacy in mice
- Regulating mammalian target of Rapamycin to tune vaccination-induced CD8+ T cell responses for tumor immunity
- Biosynthesis of the immunosuppressants FK506, FK520, and Rapamycin involves a previously undescribed family of enzymes acting on chorismate
- A comprehensive review of everolimus clinical reports: a new mammalian target of Rapamycin inhibitor
- Selective activation of Akt1 by mammalian target of Rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis
- Rab5 proteins regulate activation and localization of target of Rapamycin complex 1
- Mutations in the Arabidopsis homolog of LST8/GβL, a partner of the target of Rapamycin kinase, impair plant growth, flowering, and metabolic adaptation to long days
- Mammalian target of Rapamycin (mTOR) inhibition: potential for antiseizure, antiepileptogenic, and epileptostatic therapy
- Expanding human T regulatory cells with the mTOR-inhibitor Rapamycin
- Effects of Rapamycin and TOR on aging and memory: implications for Alzheimer’s disease
- Naturally secreted amyloid-β increases mammalian target of Rapamycin (mTOR) activity via a PRAS40-mediated mechanism
- Phospholipase D mediates nutrient input to mammalian target of Rapamycin complex 1 (mTORC1)
- Rapamycin activates autophagy in Hutchinson-Gilford progeria syndrome: implications for normal aging and age-dependent neurodegenerative disorders
- Plasma membrane recruitment and activation of the AGC kinase Ypk1 is mediated by target of Rapamycin complex 2 (TORC2) and its effector proteins Slm1 and Slm2
- Rapamycin induces Bad phosphorylation in association with its resistance to human lung cancer cells
- Mycobacterial induction of autophagy varies by species and occurs independently of mammalian target of Rapamycin inhibition
- Third target of Rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei
- Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)
- Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma
- mTOR inhibition with Rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes
- Progeria, Rapamycin and normal aging: recent breakthrough
- Resveratrol inhibits inflammatory responses via the mammalian target of Rapamycin signaling pathway in cultured LPS-stimulated microglial cells
- High-dose Rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1
- Systemic inhibition of the mammalian target of Rapamycin (mTOR) pathway reduces neuropathic pain in mice
- The differential effects of prenatal and/or postnatal Rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis …
- Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of Rapamycin)
- Nucleolar disruption in dopaminergic neurons leads to oxidative damage and parkinsonism through repression of mammalian target of Rapamycin signaling
- Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells
- The mTOR kinase inhibitor Rapamycin decreases iNOS mRNA stability in astrocytes
- Insulin-like peptides and the target of Rapamycin pathway coordinately regulate blood digestion and egg maturation in the mosquito Aedes aegypti
- Heightened uterine mammalian target of Rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice
- inhibition of the mammalian target of Rapamycin pathway by Rapamycin blocks cocaine-induced locomotor sensitization
- Tolerance induction by exosomes from immature dendritic cells and Rapamycin in a mouse cardiac allograft model
- Rapamycin is a potent inhibitor of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
- Characterization of the metabolic phenotype of Rapamycin-treated CD8+ T cells with augmented ability to generate long-lasting memory cells
- Light regulation of protein dimerization and kinase activity in living cells using photocaged Rapamycin and engineered FKBP
- Mammalian target of Rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain
- Metformin promotes progesterone receptor expression via inhibition of mammalian target of Rapamycin (mTOR) in endometrial cancer cells
- A critical role for non-coding RNA GAS5 in growth arrest and Rapamycin inhibition in human T-lymphocytes
- Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of Rapamycin complex 1 (mTORC1) signaling
- Dramatic improvement of facial angiofibromas in tuberous sclerosis with topical Rapamycin: optimizing a treatment protocol
- Mapping the spatio-temporal pattern of the mammalian target of Rapamycin (mTOR) activation in temporal lobe epilepsy
- Rapamycin inhibits lymphatic endothelial cell tube formation by downregulating vascular endothelial growth factor receptor 3 protein expression
- Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of Rapamycin complex 1 activity
- Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor
- Mammalian target of Rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons
- Mammalian target of Rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1
- Proteomic identification of novel targets regulated by the mammalian target of Rapamycin pathway during oligodendrocyte differentiation
- Phosphoproteomic profiling of in vivo signaling in liver by the mammalian target of Rapamycin complex 1 (mTORC1)
- The influence of co-solvents on the stability and bioavailability of Rapamycin formulated in self-microemulsifying drug delivery systems
- Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of Rapamycin pathway
- Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
- Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy
- inhibition of mTOR by Rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory
- Convergence of the mammalian target of Rapamycin complex 1-and glycogen synthase kinase 3-β–signaling pathways regulates the innate inflammatory response
- Rapamycin for Treatment of Epilepsy: Antiseizure, Antiepileptogenic, Both, or Neither? Rapamycin for Treatment of Epilepsy
- Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis
- Stimulation of autophagy by Rapamycin protects neurons from remote degeneration after acute focal brain damage
- The physiology and pathophysiology of Rapamycin resistance: implications for cancer
- Combination therapy targeting Akt and mammalian target of Rapamycin improves functional outcome after controlled cortical impact in mice
- Rapamycin paradox resolved
- Combining mTOR inhibitors with Rapamycin-resistant T cells: a two-pronged approach to tumor elimination
- Circadian regulation of mammalian target of Rapamycin signaling in the mouse suprachiasmatic nucleus
- Mammalian Target of Rapamycin (mTOR) Inhibitors
- Dietary restriction but not Rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS
- Rapamycin with antiretroviral therapy in AIDS-associated Kaposi sarcoma: an AIDS Malignancy Consortium study
- Rapamycin reduces reactive oxygen species in cultured human corneal endothelial cells
- mTOR-dependent regulation of PHLPP expression controls the Rapamycin sensitivity in cancer cells
- Mammalian target of Rapamycin integrates diverse inputs to guide the outcome of antigen recognition in T cells
- Targeting the mammalian target of Rapamycin (mTOR) in cancer therapy: lessons from past and future perspectives
- … mechanism of atorvastatin to protect mesenchymal stem cells from hypoxia and serum deprivation via AMP-activated protein kinase/mammalian target of Rapamycin …
- Consolidation and reconsolidation of contextual fear memory requires mammalian target of Rapamycin-dependent translation in the dorsal hippocampus
- Effects of cyclosporine, tacrolimus and Rapamycin on renal calcium transport and vitamin D metabolism
- AMP-dependent kinase/mammalian target of Rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications
- Ghrelin contributes to derangements of glucose metabolism induced by Rapamycin in mice
- TORC1 of fission yeast is Rapamycin‐sensitive
- Target-of-Rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation
- Therapy of sclerodermatous chronic graft-versus-host disease with mammalian target of Rapamycin inhibitors
- The tuberous sclerosis complex–mammalian target of Rapamycin pathway maintains the quiescence and survival of naive T cells
- Low dose Rapamycin exacerbates autoimmune experimental uveitis
- Rapamycin impairs proliferation of transplanted islet β cells
- The role of mammalian target of Rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes
- Observations on enhanced port wine stain blanching induced by combined pulsed dye laser and Rapamycin administration
- Kinome-wide selectivity profiling of ATP-competitive mammalian target of Rapamycin (mTOR) inhibitors and characterization of their binding kinetics
- Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of Rapamycin complex 1 and FoxO4
- Activation of PI3K/AKT and MAPK pathway through a PDGFRβ-dependent feedback loop is involved in Rapamycin resistance in hepatocellular carcinoma
- Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of Rapamycin (mTOR) pathways
- Redox regulates mammalian target of Rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway
- Campylobacter jejuni induces colitis through activation of mammalian target of Rapamycin signaling
- Mechanistic target of Rapamycin inhibitors in solid organ transplantation: from benchside to clinical use
- Dihydroartemisinin ameliorates inflammatory disease by its reciprocal effects on Th and regulatory T cell function via modulating the mammalian target of Rapamycin …
- Differing effects of Rapamycin and mTOR kinase inhibitors on protein synthesis
- Coupling nutrient sensing to metabolic homoeostasis: the role of the mammalian target of Rapamycin complex 1 pathway
- Impairment of object recognition memory by Rapamycin inhibition of mTOR in the amygdala or hippocampus around the time of learning or reactivation
- Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) kinase inhibitor (GDC-0980) …
- Phosphatidic acid activates mammalian target of Rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an …
- A topical combination of Rapamycin and tacrolimus for the treatment of angiofibroma due to tuberous sclerosis complex (TSC): a pilot study of nine Japanese patients …
- Assessing the effectiveness of Rapamycin on angiomyolipoma in tuberous sclerosis: a two years trial
- Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of Rapamycin
- Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer
- PDGF receptor alpha is an alternative mediator of Rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma
- The emerging role of mammalian target of Rapamycin inhibitors in the treatment of sarcomas
- Differential effects of Rapamycin on rods and cones during light-induced stress in albino mice
- Evaluation of Rapamycin-induced cell death
- Rapid cytoplasmic turnover of yeast ribosomes in response to Rapamycin inhibition of TOR
- … mammalian target of Rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of Rapamycin …
- Rapamycin attenuates the expression of cocaine‐induced place preference and behavioral sensitization
- The mammalian target of Rapamycin inhibitor everolimus (RAD001) in early breast cancer: results of a pre-operative study
- L-tryptophan-mediated enhancement of susceptibility to nonalcoholic fatty liver disease is dependent on the mammalian target of Rapamycin
- Starvation and Rapamycin differentially regulate host cell lysosome exocytosis and invasion by Trypanosoma cruzi metacyclic forms
- Paradoxical effects of Rapamycin on experimental house dust mite-induced asthma
- Magnetic nanoparticles and Rapamycin encapsulated into polymeric nanocarriers
- Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases
- Rapamycin synergizes cisplatin sensitivity in basal-like breast cancer cells through up-regulation of p73
- Rapamycin inhibits transforming growth factor β‐induced peritoneal angiogenesis by blocking the secondary hypoxic response
- Calorie restriction and Rapamycin inhibit MMTV-Wnt-1 mammary tumor growth in a mouse model of postmenopausal obesity
- Facial angiofibromas treated with topical Rapamycin: an excellent choice with fast response
- Rapamycin blocks hepatoblastoma growth in vitro and in vivo implicating new treatment options in high-risk patients
- Regulatory T cells require mammalian target of Rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice
- Spinal cord NMDA receptor-mediated activation of mammalian target of Rapamycin is required for the development and maintenance of bone cancer-induced pain …
- SIRT1 is required for the effects of Rapamycin on high glucose-inducing mesangial cells senescence
- The Akt/mammalian target of Rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas
- inhibition of Rapamycin-induced autophagy causes necrotic cell death associated with Bax/Bad mitochondrial translocation
- Emerging roles for mammalian target of Rapamycin inhibitors in the treatment of solid tumors and hematological malignancies
- An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of Rapamycin pathway and deregulation of local dendritic translation in a mouse …
- Novel synergistic antitumor effects of Rapamycin with bortezomib on hepatocellular carcinoma cells and orthotopic tumor model
- Mammalian target of Rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells
- The mechanism of mTOR (mammalian target of Rapamycin) in a mouse model of polycystic ovary syndrome (PCOS)
- Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) dual inhibitors
- Mammalian target of Rapamycin signaling in the podocyte
- Transcriptional regulation of gene expression during osmotic stress responses by the mammalian target of Rapamycin
- Mao-B elevation decreases parkin’s ability to efficiently clear damaged mitochondria: protective effects of Rapamycin
- Immunoregulatory properties of Rapamycin-conditioned monocyte-derived dendritic cells and their role in transplantation
- Novel feedback inhibition of surface antigen synthesis by mammalian target of Rapamycin (mTOR) signal and its implication for hepatitis B virus tumorigenesis and …
- A Hexane Fraction of Guava Leaves (Psidium guajava L.) Induces Anticancer Activity by Suppressing AKT/Mammalian Target of Rapamycin/Ribosomal p70 S6 …
- Clinical activity of mammalian target of Rapamycin inhibitors in solid tumors
- A novel application of topical Rapamycin formulation, an inhibitor of mTOR, for patients with hypomelanotic macules in tuberous sclerosis complex
- Targeting notch pathway enhances Rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation
- Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle
- Mammalian target of Rapamycin expression in poorly differentiated endocrine carcinoma: clinical and therapeutic future challenges
- Clinical and histopathologic characteristics of rash in cancer patients treated with mammalian target of Rapamycin inhibitors
- Grape polyphenols inhibit Akt/mammalian target of Rapamycin signaling and potentiate the effects of gefitinib in breast cancer
- Rapamycin increases the yield and effector function of human γδ T cells stimulated in vitro
- Rapamycin combined with TGF-β converts human invariant NKT cells into suppressive Foxp3+ regulatory cells
- Effect of dietary choline on growth, intestinal enzyme activities and relative expressions of target of Rapamycin and eIF4E-binding protein2 gene in muscle …
- Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of Rapamycin (mTOR)-dependent inhibition of …
- Role of mammalian target of Rapamycin in hypoxic or ischemic brain injury: potential neuroprotection and limitations
- Spinal phosphinositide 3-Kinase–Akt–Mammalian target of Rapamycin signaling cascades in inflammation-induced hyperalgesia
- Enteric-delivered Rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence
- Mechanistic or mammalian target of Rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging
- Intermittent supplementation with Rapamycin as a dietary restriction mimetic
- Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of Rapamycin interaction proteome
- The histone H3 lysine 56 acetylation pathway is regulated by target of Rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis
- TOR: target of Rapamycin
- Ksp1 kinase regulates autophagy via the target of Rapamycin complex 1 (TORC1) pathway
- Multiple site acetylation of Rictor stimulates mammalian target of Rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein
- Clinical outcomes in kidney transplant recipients receiving long‐term therapy with inhibitors of the mammalian target of Rapamycin
- Rapamycin preconditioning attenuates transient focal cerebral ischemia/reperfusion injury in mice
- … of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of Rapamycin complex 1 (mTORC1) …
- Mammalian target of Rapamycin and head and neck squamous cell carcinoma
- Rapamycin-insensitive mTORC1 activity controls eIF4E: 4E-BP1 binding
- Mammalian target of Rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN
- Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy
- Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling network in cancer stem cells
- Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase …
- Mechanistic mammalian target of Rapamycin (mTOR) cell signaling: effects of select nutrients and secreted phosphoprotein 1 on development of mammalian …
- The mTOR (mammalian target of Rapamycin) kinase maintains integrity of mTOR complex 2
- Rapamycin-mediated mTOR inhibition attenuates survivin and sensitizes glioblastoma cells to radiation therapy
- Creating diverse target-binding surfaces on FKBP12: synthesis and evaluation of a Rapamycin analogue library
- Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures
- A retrospective review of oral low-dose sirolimus (Rapamycin) for the treatment of active uveitis
- Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by Rapamycin
- Drosophila insulin and target of Rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo
- Rapamycin treatment inhibits CHO cell death in a serum‐free suspension culture by autophagy induction
- Mammalian target of Rapamycin (mTOR) inhibitors slow skin carcinogenesis, but impair wound healing
- Rapamycin Reverses Splenomegaly and Inhibits Tumor Development in a Transgenic Model of Epstein-Barr Virus–Related Burkitt’s Lymphoma
- A combined approach of classical mutagenesis and rational metabolic engineering improves Rapamycin biosynthesis and provides insights into methylmalonyl-CoA …
- The risk of skin rash and stomatitis with the mammalian target of Rapamycin inhibitor temsirolimus: a systematic review of the literature and meta-analysis
- Rapamycin reduces oxidative stress in frataxin-deficient yeast cells
- Advantage of Rapamycin over mycophenolate mofetil when used with tacrolimus for simultaneous pancreas kidney transplants: randomized, single‐center trial at 10 …
- Phosphorylation of Raptor by p38β participates in arsenite-induced mammalian target of Rapamycin complex 1 (mTORC1) activation
- Synergistic activity of Rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis
- … and a signaling core formed by bifunctional Akt, extracellular signal-regulated kinase (ERK) 1/2, and mammalian target of Rapamycin complex 1 (mTORC1) …
- LST8 regulates cell growth via target-of-Rapamycin complex 2 (TORC2)
- The mammalian target of Rapamycin pathway is widely activated without PTEN deletion in renal cell carcinoma metastases
- Rapamycin induces p53-independent apoptosis through the mitochondrial pathway in non-small cell lung cancer cells
- Evaluation of sphingolipid metabolism in renal cortex of rats with streptozotocin-induced diabetes and the effects of Rapamycin
- Dissecting mammalian target of Rapamycin to promote longevity
- Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium
- Impact of Rapamycin on peritoneal fibrosis and transport function
- Predictive biomarkers for the activity of mammalian target of Rapamycin (mTOR) inhibitors
- Rapamycin‐Induced Hypophosphatemia and Insulin Resistance Are Associated With mTORC2 Activation and Klotho Expression
- Phospshoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) dual inhibitors: discovery and structure–activity relationships of a series of quinoline and …
- Emergence of the phosphoinositide 3-kinase-Akt-mammalian target of Rapamycin axis in transforming growth factor-β-induced epithelial-mesenchymal transition
- Activation of mammalian target of Rapamycin pathway confers adverse outcome in nonsmall cell lung carcinoma
- Dual inhibition of phosphatidylinositol 3‐kinase/Akt and mammalian target of Rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid …
- S6 kinase 1 is required for Rapamycin-sensitive liver proliferation after mouse hepatectomy
- Metabolic regulation, mitochondria and the life-prolonging effect of Rapamycin: a mini-review
- Induction of melanogenesis by Rapamycin in human MNT-1 melanoma cells
- Calcineurin inhibitor sparing regimens using m‐target of Rapamycin inhibitors: an opportunity to improve cardiovascular risk following kidney transplantation?
- The mammalian target of Rapamycin pathway as a therapeutic target in multiple myeloma
- … and its associated cell death by “sphingolipid rheostat”: reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of Rapamycin …
- Rapamycin sensitive mTOR activation mediates nerve growth factor (NGF) induced cell migration and pro-survival effects against hydrogen peroxide in retinal pigment …
- Regulation of the glutamate transporter EAAT3 by mammalian target of Rapamycin mTOR
- Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of Rapamycin (mTOR)
- The mammalian target of Rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in …
- Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex …
- NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitors, enhance tumor and endothelial cell …
- An elaborate regulation of Mammalian target of Rapamycin activity is required for somatic cell reprogramming induced by defined transcription factors
- Rapamycin-induced posterior reversible encephalopathy in a kidney transplantation patient
- Mammalian target of Rapamycin pathway activation is associated to RET mutation status in medullary thyroid carcinoma
- … secretion via down-regulation of surface expression of adrenergic α2A receptor through the mTOR (mammalian target of Rapamycin) pathway: implication in …
- Rapamycin enhances docetaxel-induced cytotoxicity in a androgen-independent prostate cancer xenograft model by survivin downregulation
- Beta cell function during Rapamycin monotherapy in long-term type 1 diabetes
- Temporal regulation of Rapamycin on memory CTL programming by IL-12
- Rapamycin prevents endothelial cell migration by inhibiting the endothelial-to-mesenchymal transition and matrix metalloproteinase-2 and-9: an in vitro study
- TGFβ‐and bleomycin‐induced extracellular matrix synthesis is mediated through Akt and mammalian target of Rapamycin (mTOR)
- cAMP inhibits mammalian target of Rapamycin complex-1 and-2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity
- Enhanced delivery of Rapamycin by V156K-apoA-I high-density lipoprotein inhibits cellular proatherogenic effects and senescence and promotes tissue regeneration
- Interpreting mammalian target of Rapamycin and cell growth inhibition in a genetically engineered mouse model of Nf1-deficient astrocytes
- First report of a novel abluminal groove filled biodegradable polymer Rapamycin-eluting stent in de novo coronary artery disease: results of the first in man FIREHAWK …
- Autophagy induced by Rapamycin and carbon‐starvation have distinct proteome profiles in Aspergillus nidulans
- An emerging role for the mammalian target of Rapamycin in “pathological” protein translation: relevance to cocaine addiction
- Rapamycin-cyclodextrin complexation: improved solubility and dissolution rate
- inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235
- Regulation of mammalian target of Rapamycin and mitogen activated protein kinase pathways by BCR–ABL
- mTOR in podocyte function: is Rapamycin good for diabetic nephropathy?
- Yin Yang 1 deficiency in skeletal muscle protects against Rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling
- ULK1, mammalian target of Rapamycin, and mitochondria: linking nutrient availability and autophagy
- Mammalian target of Rapamycin mediates the angiogenic effects of leptin in human hepatic stellate cells
- Forced degradation studies of Rapamycin: Identification of autoxidation products
- Inactivation of mammalian target of Rapamycin (mTOR) by Rapamycin in a murine model of lipopolysaccharide-induced acute lung injury
- Pharmacological targeting of mammalian target of Rapamycin inhibits ovarian granulosa cell tumor growth
- Innovations therapy: mammalian target of Rapamycin (mTOR) inhibitors for the treatment of neuroendocrine tumors
- Nitrogen-responsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by Rapamycin and the other by …
- Myopathy caused by mammalian target of Rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function
- Remarkable inhibition of mTOR signaling by the combination of Rapamycin and 1, 4‐phenylenebis (methylene) selenocyanate in human prostate cancer cells
- Regulatory T cells expanded by Rapamycin in vitro suppress colitis in an experimental mouse model
- Combination of an allosteric Akt Inhibitor MK-2206 with etoposide or Rapamycin enhances the antitumor growth effect in neuroblastoma
- Localized ultrasound enhances delivery of Rapamycin from microbubbles to prevent smooth muscle proliferation
- inhibition of Akt (ser473) phosphorylation and Rapamycin-resistant cell growth by knockdown of mammalian target of Rapamycin with small interfering RNA in vascular …
- Myxoma virus combined with Rapamycin treatment enhances adoptive T cell therapy for murine melanoma brain tumors
- Rapamycin and mTORC1 inhibition in the mouse: skin cancer prevention
- Rapamycin suppresses ROS-dependent apoptosis caused by selenomethionine in A549 lung carcinoma cells
- Curcumin dually inhibits both mammalian target of Rapamycin and nuclear factor-κB pathways through a crossed phosphatidylinositol 3-kinase/Akt/IκB kinase complex …
- Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor Rapamycin
- Rapamycin regulates bleomycin-induced lung damage in SP-C-deficient mice
- Therapeutic efficacy of polyclonal tregs does not require Rapamycin in a low-dose irradiation bone marrow transplantation model
- Effects of intermittent and chronic calorie restriction on mammalian target of Rapamycin (mTOR) and IGF-I signaling pathways in mammary fat pad tissues and …
- Onychopathy induced by temsirolimus, a mammalian target of Rapamycin inhibitor
- … ) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of Rapamycin (mTOR) pathway in …
- Modulation of sodium iodide symporter expression and function by LY294002, Akti-1/2 and Rapamycin in thyroid cells
- Rapamycin provides a therapeutic option through inhibition of mTOR signaling in chronic myelogenous leukemia
- Akt/mammalian target of Rapamycin signaling pathway regulates neurite outgrowth in cerebellar granule neurons stimulated by methylcobalamin
- Sorafenib enhances the therapeutic efficacy of Rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA
- V‐AKT murine thymoma viral oncogene homolog/mammalian target of Rapamycin activation induces a module of metabolic changes contributing to growth in insulin …
- Overexpression of the mammalian target of Rapamycin (mTOR) and angioinvasion are poor prognostic factors in early stage NSCLC: a verification study
- Unrestrained mammalian target of Rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to …
- Rapamycin has age‐, treatment paradigm‐, and model‐specific anticonvulsant effects and modulates neuropeptide Y expression in rats
- Sorafenib induces apoptotic cell death in human non-small cell lung cancer cells by down-regulating mammalian target of Rapamycin (mTOR)-dependent survivin …
- Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of Rapamycin (mTOR) in renal cell cancer
- Ex vivo Rapamycin treatment of human cord blood CD34+ cells enhances their engraftment of NSG mice
- Hypoxia‐inducible factor and mammalian target of Rapamycin pathway markers in urothelial carcinoma of the bladder: possible therapeutic implications
- Multi-timescale dynamics study of FKBP12 along the Rapamycin–mTOR binding coordinate
- Rapamycin: killing two birds with one stone
- Immunomodulatory synergy by combining atorvastatin and Rapamycin in the treatment of experimental autoimmune encephalomyelitis (EAE)
- Structure–activity relationships of phosphoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) dual inhibitors: investigations of various 6, 5-heterocycles …
- FLZ protects dopaminergic neuron through activating protein kinase B/mammalian target of Rapamycin pathway and inhibiting RTP801 expression in Parkinson’s …
- Uterine histotroph and conceptus development: select nutrients and secreted phosphoprotein 1 affect mechanistic target of Rapamycin cell signaling in ewes
- MicroRNA-100 regulates neovascularization by suppression of mammalian target of Rapamycin in endothelial and vascular smooth muscle cells
- Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from Rapamycin
- Rapamycin inhibits formation of urethral stricture in rabbits
- Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats
- Rapamycin inhibits the proliferation and apoptosis of gastric cancer cells by down regulating the expression of survivin.
- Topical Rapamycin suppresses the angiogenesis pathways induced by pulsed dye laser: molecular mechanisms of inhibition of regeneration and revascularization of …
- Early use of mammalian target of Rapamycin inhibitors is an independent risk factor for incisional hernia development after liver transplantation
- … )phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of …
- Comparative efficacy of vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor (TKI) and mammalian target of Rapamycin (mTOR) inhibitor as second-line …
- Combined inhibition of PI3K and mTOR exerts synergistic antiproliferative effect, but diminishes differentiative properties of Rapamycin in acute myeloid leukemia cells
- Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency
- Effects of STAT3 gene silencing and Rapamycin on apoptosis in hepatocarcinoma cells
- Mammalian target of Rapamycin as a target in hematological malignancies
- … ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of Rapamycin complex 1), FOXM1 …
- Osmotic stress regulates mammalian target of Rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylation
- Rapamycin-loaded nanoparticles for inhibition of neointimal hyperplasia in experimental vein grafts
- Activation of the phosphoinositide‐3‐kinase and mammalian target of Rapamycin signaling pathways are associated with shortened survival in patients with malignant …
- Rictor-dependent AKT activation and inhibition of urothelial carcinoma by Rapamycin
- Src kinase activity coordinates cell adhesion and spreading with activation of mammalian target of Rapamycin in pancreatic endocrine tumour cells
- Rapamycin inhibits osteoclast formation in giant cell tumor of bone through the C/EBPβ-MafB axis
- Insulin‐like growth factor I regulates G2/M progression through mammalian target of Rapamycin signaling in oligodendrocyte progenitors
- … method validation of Rapamycin in ocular matrix by QTRAP LC–MS/MS: Application to rabbit anterior tissue distribution by topical administration of Rapamycin …
- Target of Rapamycin complex 2 signals to downstream effector yeast protein kinase 2 (Ypk2) through adheres-voraciously-to-target-of-Rapamycin-2 protein 1 …
- Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of Rapamycin as a therapeutic strategy for acute leukemia …
- Mammalian target of Rapamycin signal inhibitors could play a role in the treatment of BK polyomavirus nephritis in renal allograft recipients
- A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has Rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on …
- Multifaceted role of insulin-like growth factors and mammalian target of Rapamycin in skeletal muscle
- Local delivery of Rapamycin: a toxicity and efficacy study in an experimental malignant glioma model in rats
- Rapamycin enhances the activity of oncolytic herpes simplex virus against tumor cells that are resistant to virus replication
- … -mediated activation of phospholipase D and mammalian target of Rapamycin (mTOR) regulates proliferation and Rapamycin sensitivity of hepatocarcinoma …
- Blocking mTORC1 activity by Rapamycin leads to impairment of spatial memory retrieval but not acquisition in C57BL/6J mice
- Phosphatidylinositol 3-kinase/AKT/mammalian target of Rapamycin pathway inhibition: a breakthrough in the management of luminal (ER+/HER2−) breast cancers?
- Sorafenib, a multikinase inhibitor, is effective in vitro against non‐hodgkin lymphoma and synergizes with the mTOR inhibitor Rapamycin
- Mammalian target of Rapamycin signaling pathway contributes to glioma progression and patients’ prognosis
- The mTOR-inhibitor Rapamycin mediates proteinuria in nephrotoxic serum nephritis by activating the innate immune response
- … molecular approach to the PI3K/AKT/mTOR (phosphoinositide 3‐kinase/v‐akt murine thymoma viral oncogene/mammalian target of Rapamycin) pathway in bladder …
- Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation
- The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of Rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 …
- Phosphorylated mammalian target of Rapamycin expression is associated with the response to chemoradiotherapy in patients with esophageal squamous cell …
- IL-33 induces innate lymphoid cell–mediated airway inflammation by activating mammalian target of Rapamycin
- … recognition memory consolidation involves activation of the extracellular signal-regulated kinase (ERK) and mammalian target of Rapamycin (mTOR) pathways in the …
- Improved insulin sensitivity by Rapamycin is associated with reduction of mTOR and S6K1 activities in L6 myotubes
- Rheb/mTOR activation and regulation in cancer: novel treatment strategies beyond Rapamycin
- Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of Rapamycin pathway signaling limits the antitumor …
- Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with Rapamycin, an mTOR inhibitor and anti-aging drug
- Dual targeting of phosphoinositide 3-kinase and mammalian target of Rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma
- Topical 0.1% Rapamycin for angiofibromas in paediatric patients with tuberous sclerosis: a pilot study of four patients
- Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility
- Rapamycin sensitive ROS formation and Na+/H+ exchanger activity in dendritic cells
- Rheb, an activator of target of Rapamycin, in the blackback land crab, Gecarcinus lateralis: cloning and effects of molting and unweighting on expression in skeletal …
- Tramadol pretreatment enhances ketamine-induced antidepressant effects and increases mammalian target of Rapamycin in rat hippocampus and prefrontal …
- Phosphatidylinositol 3, 5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of Rapamycin 1
- Novel withanolides target medullary thyroid cancer through inhibition of both RET phosphorylation and the mammalian target of Rapamycin pathway
- Regulation of mammalian target of Rapamycin complex 1 (mTORC1) by hypoxia: causes and consequences
- Non-clear cell renal cell carcinoma: does the mammalian target of Rapamycin represent a rational therapeutic target?
- Rapamycin decreases airway remodeling and hyperreactivity in a transgenic model of noninflammatory lung disease
- Mammalian target of Rapamycin inhibition in polycystic kidney disease: From bench to bedside
- Rapamycin suppresses the recurrent excitatory circuits of dentate gyrus in a mouse model of temporal lobe epilepsy
- Relief with Rapamycin: mTOR inhibition protects against radiation-induced mucositis
- Rapamycin potentiates cytotoxicity by docetaxel possibly through downregulation of Survivin in lung cancer cells
- Targeting the JNK signaling pathway potentiates the antiproliferative efficacy of Rapamycin in LS174T colon cancer cells
- Rapamycin decreases survivin expression to induce NSCLC cell apoptosis under hypoxia through inhibiting HIF-1α induction
- Controlled release formulations of IL-2, TGF-β1 and Rapamycin for the induction of regulatory T cells
- Differential regulation of the p73 cistrome by mammalian target of Rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis
- Rapamycin (sirolimus) protects against hypoxic damage in primary heart cultures via Na+/Ca2+ exchanger activation
- Surface crystallization of Rapamycin on stents using a temperature induced process
- Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor GDC-0980 and prediction of its …
- Rapamycin impairs UV induction of mutant‐p53 overexpressing cell clusters without affecting tumor onset
- Chemoprevention of age-related macular regeneration (AMD) with Rapamycin
- FOXO3a reactivation mediates the synergistic cytotoxic effects of Rapamycin and cisplatin in oral squamous cell carcinoma cells
- Cooperative benefit for the combination of Rapamycin and imatinib in tuberous sclerosis complex neoplasia
- Rapamycin‐sensitive signals control TCR/CD28‐driven Ifng, Il4 and Foxp3 transcription and promoter region methylation
- Topical use of Rapamycin in herpetic stromal keratitis
- Flt3L combined with Rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice
- Rho-associated kinase connects a cell cycle-controlling anchorage signal to the mammalian target of Rapamycin pathway
- Rapamycin induces the anti-apoptotic protein survivin in neuroblastoma
- Transcript abundance of hormone receptors, mammalian target of Rapamycin pathway-related kinases, insulin-like growth factor I, and milk proteins in porcine …
- Mammalian target of Rapamycin regulates expression of β-catenin in hepatocellular carcinoma
- Everolimus: a new mammalian target of Rapamycin inhibitor for the treatment of advanced renal cell carcinoma
- Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes
- mTORC1 activity as a determinant of cancer risk–rationalizing the cancer-preventive effects of adiponectin, metformin, Rapamycin, and low-protein vegan diets
- Efficacy of ganitumab (AMG 479), alone and in combination with Rapamycin, in Ewing’s and osteogenic sarcoma models
- Potent, selective, and orally bioavailable inhibitors of the mammalian target of Rapamycin kinase domain exhibiting single agent antiproliferative activity
- NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of Rapamycin (mTOR) signaling in T …
- The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of Rapamycin complex 1 (mTORC1) signaling in vivo …
- Mammalian target of Rapamycin complex 2 regulates inflammatory response to stress
- Sindbis virus replication, is insensitive to Rapamycin and torin1, and suppresses Akt/mTOR pathway late during infection in HEK cells
- Potent, selective, and orally bioavailable inhibitors of mammalian target of Rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine
- Rapamycin combined with allogenic immature dendritic cells selectively expands CD4+ CD25+ Foxp3+ regulatory T cells in rats
- Identification of mammalian target of Rapamycin as a direct target of fenretinide both in vitro and in vivo
- Positively charged amphiphilic chitosan derivative for the transscleral delivery of Rapamycin
- Growth hormone improves growth retardation induced by Rapamycin without blocking its antiproliferative and antiangiogenic effects on rat growth plate
- New developments in mammalian target of Rapamycin inhibitors for the treatment of sarcoma
- Temsirolimus in advanced leiomyosarcomas: patterns of response and correlation with the activation of the mammalian target of Rapamycin pathway
- Mammalian target of Rapamycin (mTOR) inhibition reduces cerebral vasospasm following a subarachnoid hemorrhage injury in canines
- Rapamycin affects tissue plasminogen activator and plasminogen activator inhibitor 1 expression: a potential prothrombotic mechanism of drug-eluting stents
- Rapamycin inhibits the invasive ability of thyroid cancer cells by down‐regulating the expression of VEGF‐C in vitro
- Antileukaemia effect of Rapamycin alone or in combination with daunorubicin on Ph+ acute lymphoblastic leukaemia cell line
- 5′-Adenosine monophosphate-activated protein kinase–mammalian target of Rapamycin axis as therapeutic target for age-related macular degeneration
- Toxicity spectrum of inhibitors of mammalian target of Rapamycin in organ transplantation: etiology, pathogenesis and treatment
- Nuclear factor of activated T-cell c3 inhibition of mammalian target of Rapamycin signaling through induction of regulated in development and DNA damage response …
- inhibition of mammalian target of Rapamycin: two goals with one shot?
- The FKBP–Rapamycin binding domain of human TOR undergoes strong conformational changes in the presence of membrane mimetics with and without the regulator …
- Combination testing (Stage 2) of the Anti‐IGF‐1 receptor antibody IMC‐A12 with Rapamycin by the pediatric preclinical testing program
- Rapamycin inhibits lipopolysaccharide induction of granulocyte‐colony stimulating factor and inducible nitric oxide synthase expression in macrophages by reducing …
- … study of 3-in-1 poly (ethylene glycol)-block-poly (D, L-lactic acid) micelles carrying paclitaxel, 17-allylamino-17-demethoxygeldanamycin, and Rapamycin
- Intranuclear function for protein phosphatase 2A: Pph21 and Pph22 are required for Rapamycin-induced GATA factor binding to the DAL5 promoter in yeast
- mTORC1/2 and Rapamycin in female Han: SPRD rats with polycystic kidney disease
- Mammalian target of Rapamycin (mTOR) phosphorylates inositol 1, 4, 5-trisphosphate receptor type 2 and increases its Ca2+ release activity
- inhibition of Mammalian target of Rapamycin in human acute myeloid leukemia cells has diverse effects that depend on the environmental in vitro stress
- Evaluation of an AAV2-based Rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system
- Target of Rapamycin (TOR) controls vitellogenesis via activation of the S6 kinase in the fat body of the tick, Haemaphysalis longicornis
- Effect of complementary pathway blockade on efficacy of combination enzastaurin and Rapamycin
- The expression of URGCP gene in prostate cancer cell lines: correlation with Rapamycin
- Targeting the autophagy pathway using ectopic expression of Beclin 1 in combination with Rapamycin in drug-resistant v-Ha-ras-transformed NIH 3T3 cells
- Targeting glycolysis in leukemia: a novel inhibitor 3-BrOP in combination with Rapamycin
- Local application of Rapamycin inhibits vein graft restenosis in rabbits
- Drosophila larvae lacking the bcl-2 gene, buffy, are sensitive to nutrient stress, maintain increased basal target of Rapamycin (Tor) signaling and exhibit …
- … proteolysis system by amino acids and insulin involves the adenosine monophosphate-activated protein kinase and mammalian target of Rapamycin pathways in rat …
- Targeted inhibition of mammalian target of Rapamycin (mTOR) signaling pathway inhibits proliferation and induces apoptosis of laryngeal carcinoma cells in vitro
- Rapamycin induces differentiation of glioma stem/progenitor cells by activating autophagy
- Pharmacologic synergy between dual phosphoinositide-3-kinase and mammalian target of Rapamycin inhibition and 5-Fluorouracil in PIK3CA mutant gastric cancer …
- Rapamycin: A rheostat for CD8+ T-cell-mediated tumor therapy
- Intranasal Rapamycin rescues mice from staphylococcal enterotoxin B-induced shock
- A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice
- Aberrant expression of the mammalian target of Rapamycin, hypoxia-inducible factor-1α, and glucose transporter 1 in the development of ovarian clear-cell …
- Effects of FTY720 and Rapamycin on inflammation in taurocholate-induced acute pancreatitis in the rat
- A novel method for the elution of sirolimus (Rapamycin) in drug-elution stents
- Krüppel‐like factor 4 is induced by Rapamycin and mediates the anti‐proliferative effect of Rapamycin in rat carotid arteries after balloon injury
- Adiponectin inhibits PDGF-induced mesangial cell proliferation: regulation of mammalian target of Rapamycin-mediated survival pathway by adenosine 5 …
- Rapamycin enhances dimethyl sulfoxide-mediated growth arrest in human myelogenous leukemia cells
- Regulation of karyopherin α1 and nuclear import by mammalian target of Rapamycin
- Nuclear PIM1 confers resistance to Rapamycin-impaired endothelial proliferation
- Rapamycin-induced impaired wound healing is associated with compromised tissue lactate accumulation and extracellular matrix remodeling
- Mechanism of activation of AMPK and upregulation of OGG1 by Rapamycin in cancer cells
- The translational response of the human mdm2 gene in HEK293T cells exposed to Rapamycin: a role for the 5′-UTRs
- Hepatocyte growth factor-induced c-Src-phosphatidylinositol 3-kinase-AKT-mammalian target of Rapamycin pathway inhibits dendritic cell activation by blocking IκB …
- Combination of ATP-competitive mammalian target of Rapamycin inhibitors with standard chemotherapy for colorectal cancer
- Antitumor efficacy of mammalian target of Rapamycin inhibitor therapy in liver transplant recipients with oncological disease: a case-control study
- The mammalian Target of Rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signaling
- Effects of Rapamycin on expression of Bcl-2 and Bax in human lens epithelial cells and cell cycle in rats
- Rapamycin treatment causes developmental delay, pigmentation defects, and gastrointestinal malformation on Xenopus embryogenesis
- Systemic Rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study
- Cardiovascular risk in kidney transplant recipients receiving mammalian target of Rapamycin inhibitors
- Morphoproteomics demonstrates activation of mammalian target of Rapamycin pathway in papillary thyroid carcinomas with nuclear translocation of mTOR in …
- Effect of combination of Rapamycin and cisplatin on human cervical carcinoma Hela cells
- Indications and effectiveness of the mammalian target of Rapamycin in liver transplantation
- Rapamycin prevents interstitial fibrosis in renal allografts through decreasing angiogenesis and inflammation
- Rapamycin induced ultrastructural and molecular alterations in glomerular podocytes in healthy mice
- Conversion to low-dose tacrolimus or Rapamycin 3 months after kidney transplantation: a prospective, protocol biopsy-guided study
- Rapamycin‐mediated suppression of renal cyst expansion in del34 Pkd1−/− mutant mouse embryos: An investigation of the feasibility of renal cyst prevention in the …
- Rapamycin-conditioned, alloantigen-pulsed myeloid dendritic cells present donor MHC class I/peptide via the semi-direct pathway and inhibit survival of antigen …
- Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by Rapamycin
- Combined targeting of the VEGFr/EGFr and the mammalian target of Rapamycin (mTOR) signaling pathway delays cell cycle progression and alters adhesion behavior …
- One‐year clinical outcome of a randomized trial of polymer‐free paclitaxel‐eluting stents versus biodegradable polymer‐based Rapamycin‐eluting stents in patients …
- Chronic hypoxia impairs murine hippocampal development and depletes the postnatal progenitor pool by attenuating mammalian target of Rapamycin …
- inhibition of mammalian target of Rapamycin signaling by everolimus induces senescence in adult T‐cell leukemia/lymphoma and apoptosis in peripheral T‐cell …
- The inhibitory effect of Rapamycin on the oval cell response and development of preneoplastic foci in the rat
- Insulin-induced neurite-like process outgrowth: acceleration of tau protein synthesis via a phosphoinositide 3-kinase∼ mammalian target of Rapamycin pathway
- Rapamycin for life: a step to immortality
- Target of Rapamycin (TOR)–Based Therapy for Cardiomyopathy: Evidence From Zebrafish and Human Studies
- Rapamycin as immunosuppressant in murine transplantation model
- Effect of feeding a high-protein diet following an 18-hour period of feed withholding on mammalian target of Rapamycin-dependent signaling in skeletal muscle of …
- Destabilization of TNF-α mRNA by Rapamycin
- Rapamycin-based inducible translocation systems for studying phagocytosis
- Immunoexpression status and prognostic value of mammalian target of Rapamycin and hypoxia-induced pathway members in papillary cell renal cell carcinomas
- Targeting the dysregulated mammalian target of Rapamycin pathway in organ transplantation: killing 2 birds with 1 stone
- Rapamycin and 3-methyladenine regulate apoptosis and autophagy in bone-derived endothelial progenitor cells
- Expression of the mammalian target of Rapamycin pathway markers in lung adenocarcinoma and squamous cell carcinoma
- … and effectiveness of oral Rapamycin plus bare‐metal stents with drug‐eluting stents: Three‐year outcome from the randomized oral Rapamycin in Argentina (ORAR) III …
- Mammalian target of Rapamycin expression and laryngeal squamous cell carcinoma prognosis: novel preliminary evidence
- Chronic inhibition of mTOR by Rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
- Poly (ethylene glycol)-block-poly (2-methyl-2-benzoxycarbonyl-propylene carbonate) micelles for Rapamycin delivery: in vitro characterization and biodistribution
- Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease–antiprotease system by the mTOR inhibitor Rapamycin
- Enhanced sensitivity to Rapamycin following long-term oestrogen deprivation in MCF-7, T-47-D and ZR-75-1 human breast cancer cells
- Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in Saccharomyces cerevisiae
- Differential Regulation of Simultaneous Antitumor and Alloreactive CD8+ T‐Cell Responses in the Same Host by Rapamycin
- Mammalian Target of Rapamycin inhibition in Macrophages of Asymptomatic HIV+ Persons Reverses the Decrease in TLR-4–Mediated TNF-α Release through …
- Gene expression profile in response to doxorubicin–Rapamycin combined treatment of HER-2–overexpressing human mammary epithelial cell lines
- … tumour necrosis factor (TNF)‐α‐induced apoptosis through eukaryotic translation initiation factor 2α (eIF2α)‐and mammalian target of Rapamycin complex 1 (mTORC1 …
- Rapamycin combined with donor immature dendritic cells promotes liver allograft survival in association with CD4+CD25+Foxp3+ regulatory T cell expansion
- Activation of mammalian target of Rapamycin in diffuse large B-cell lymphoma: a clinicopathological study
- Rapamycin regulates the expression and activity of krüppel-like transcription factor 2 in human umbilical vein endothelial cells
- Advanced retinoblastoma treatment: targeting hypoxia by inhibition of the mammalian target of Rapamycin (mTOR) in LHBetaTag retinal tumors
- Abstract CT-02: A phase I, open label, dose escalation study of oral mammalian target of Rapamycin inhibitor INK128 administered by intermittent dosing regimens in …
- Characterization of Foxp3 gene from grass carp (Ctenopharyngodon idellus): a Rapamycin-inducible transcription factor in teleost immune system
- RETRACTED: Enhanced cellular uptake and in vivo pharmacokinetics of Rapamycin loaded cubic phase nanoparticles for cancer therapy
- Bevacizumab and Rapamycin can decrease corneal opacity and apoptotic keratocyte number following photorefractive keratectomy
- Are we ready to move away from nature? The Rapamycin story
- … renal angiomyolipomas and lymphangioleiomyomatosis presenting after two successive pregnancies successfully treated with surgery and Rapamycin
- Biochemical and pharmacological inhibition of mTOR by Rapamycin and an ATP-competitive mTOR inhibitor
- Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype
- Rapamycin selectively alters serum chemistry in diabetic mice
- Andes virus infection of lymphatic endothelial cells causes giant cell and enhanced permeability responses that are Rapamycin and vascular endothelial growth factor …
- The combination of the novel glycolysis inhibitor 3-BrOP and Rapamycin is effective against neuroblastoma
- … Akt hyperphosphorylation and an oxidative stress-mediated cell death in serum starved SK-N-SH human neuroblastoma cells that are augmented by Rapamycin
- Use of factorial design for evaluation of factors affecting the chemical stability of sirolimus (Rapamycin) in solid dosage form.
- Drosophila poly suggests a novel role for the Elongator complex in insulin receptor–target of Rapamycin signalling
- … ribosome entry site-transacting factor (ITAF) function via effects on strand annealing and results in mammalian target of Rapamycin complex 1 (mTORC1) …
- Immunohistochemical evidence of dysregulation of the mammalian target of Rapamycin pathway in primary and metastatic pheochromocytomas
- Effect of Rapamycin on high glucose-induced autophagy impairment, oxidative stress and premature senescence in rat mesangial cells in vitro
- A role of the mammalian target of Rapamycin (mTOR) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (TSC2)
- Role of Rapamycin‐Induced Autophagy in Pancreatic Islets
- Rapamycin Generates Graft-Homing Murine Suppressor CD8+ T Cells That Confer Donor-Specific Graft Protection
- Positive regulation of inositol 1,4,5‐trisphosphate‐induced ca2+ release by mammalian target of Rapamycin (mTOR) in RINm5F cells
- inhibition by Rapamycin of the lipoteichoic acid-induced granulocyte-colony stimulating factor expression in mouse macrophages
- Markers for efficacy of mammalian target of Rapamycin inhibitor
- Immunosuppressive drug Rapamycin restores sporulation competence in industrial yeasts
- Immunosuppression in kidney donors with Rapamycin and tacrolimus. Proinflammatory cytokine expression
- … stents to bare-metal stents in patients with ST-segment elevation myocardial infarction: an analysis of the RESEARCH (Rapamycin-eluting stent evaluated at …
- Mechanisms mediating the cardioprotective effects of Rapamycin in ischaemia–reperfusion injury
- Rapamycin inhibition of baculovirus recombinant (BVr) ribosomal protein S6 kinase (S6K1) is mediated by an event other than phosphorylation
- A phase I, open label, dose escalation study of an oral mammalian target of Rapamycin inhibitor INK128 administered once daily in patients with advanced …
- Mammalian target of Rapamycin inhibitors for treatment in tuberous sclerosis
- Prognostic markers in renal cell carcinoma: A focus on the ‘mammalian target of Rapamycin‘pathway
- Is proteinuria reversible, after withdrawal of mammalian target of Rapamycin inhibitors?
- Rapamycin induces heme oxygenase-1 in liver but inhibits bile flow recovery after ischemia
- Enhanced Rapamycin production in Streptomyces hygroscopicus by integrative expression of aveR, a LAL family transcriptional regulator
- Expansion of CD4+ CD25+ regulatory T cells from cord blood CD4+ cells using the common γ-chain cytokines (IL-2 and IL-15) and Rapamycin
- The phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy
- Everolimus vs. Rapamycin for treating diabetic nephropathy in diabetic mouse model
- RNA polymerase II degradation in response to Rapamycin is not mediated through ubiquitylation
- Akt (protein kinase B) isoform phosphorylation and signaling downstream of mTOR (mammalian target of Rapamycin) in denervated atrophic and hypertrophic …
- … of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with Rapamycin
- inhibition of mTORC1 kinase activates Smads 1 and 5 but not Smad8 in human prostate cancer cells, mediating cytostatic response to Rapamycin
- Comparative assessment of mammalian target of Rapamycin inhibitor‐eluting stents in the treatment of coronary artery bifurcation lesions: The CASTOR‐Bifurcation …
- Multimodal biomarker investigation on efficacy and mechanism of action for the mammalian target of Rapamycin inhibitor, temsirolimus, in a preclinical mammary …
- Rapamycin inhibiting Jurkat T cells viability through changing mRNA expression of serine/threonine protein phosphatase 2A
- Multispecies-compatible antitumor effects of a cross-species small-interfering RNA against mammalian target of Rapamycin
- The target of Rapamycin: structure and functions
- Artemisinin and Rapamycin compromise nitric oxide-driven and hypoxia-triggered acute articular synovitis in mice
- Multimodal imaging of growth and Rapamycin-induced regression of colonic adenomas in APC mutation-dependent mouse
- Forever young? Exploring the link between Rapamycin, longevity and cancer
- Identification of novel Rapamycin derivatives as low-level impurities in active pharmaceutical ingredients
- Deoxyribose protects against Rapamycin-induced cytotoxicity in colorectal cancer cells in vitro
- Rapamycin-induced tumor vasculature remodeling in rhabdomyosarcoma xenografts increases the effectiveness of adjuvant ionizing radiation
- Mammalian target of Rapamycin inhibitors in organ transplantation: an unkept promise
- Study on the rat intestinal absorption of Rapamycin formulated in self-microemulsifying drug delivery system by single-pass intestinal perfusion technique [J]
- Synergistic cytotoxic effects of Rapamycin and idarubicin on human acute T-cell lymphoblastic leukemia Jurkat cells
- Impact of pyrrolidine dithiocarbamate and interleukin-6 on mammalian target of Rapamycin complex 1 regulation and global protein translation
- Molecular characterization and functional analysis of Cashmere goat mammalian target of Rapamycin
- Tumor growth effects of Rapamycin on human biliary tract cancer cells
- Decrease in transient receptor potential melastatin 6 mRNA stability caused by Rapamycin in renal tubular epithelial cells
- Rapamycin and a hyaluronic acid-carboxymethylcellulose membrane did not lead to reduced adhesion formations in a rat abdominal adhesion model
- inhibition of mammalian target of Rapamycin signaling by CCI-779 (Temsirolimus) induces growth inhibition and cell cycle arrest in Cashmere goat fetal fibroblasts …
- Cost-effectiveness analysis of the early conversion of tacrolimus to mammalian target of Rapamycin inhibitors in patients with renal transplantation
- Ex vivo transfer of adenovirus-mediated CTLA4Ig gene combined with a short course of Rapamycin therapy prolongs free flap allograft survival
- From node to pathway blockade: lessons learned from targeting mammalian target of Rapamycin.
- A study about drug combination therapy of Schisandra sphenanthera extract and Rapamycin in healthy subjects
- Nonobese diabetic natural killer cells: a barrier to allogeneic chimerism that can be reduced by Rapamycin
- Rapamycin synergizes with low dose oxaliplatin in the HCT116 colon cancer cell line by inducing enhanced apoptosis
- Metabolic function of a suboptimal transplanted islet mass in nonhuman primates on Rapamycin monotherapy
- Switching from calcineurin inhibitors to mammalian target of Rapamycin inhibitors—finally caught the right wave?
- The phosphatidylinositol 3′ kinase-Akt-mammalian target of Rapamycin pathway in smooth muscle tumors of the uterus: selected protein expression patterns and …
- Targeted therapy in sarcomas: mammalian target of Rapamycin inhibitors from bench to bedside
- REDV/Peptide conjugated Rapamycin-loaded polymer matrix for endothelial cells selectivity
- Rapamycin protects against dominant negative-HNF1A-induced apoptosis in INS-1 cells
- A simple and efficient route to the FKBP-binding domain from Rapamycin
- Functional analysis of the single Est1/Ebs1 homologue in Kluyveromyces lactis reveals roles in both telomere maintenance and Rapamycin resistance
- Linking molecular feature space and disease terms for the immunosuppressive drug Rapamycin
- Effect of Rapamycin on immunity induced by vector-mediated dystrophin expression in mdx skeletal muscle
- Modified Rapamycin targets PKD
- Prevalence and clinical significance of mammalian target of Rapamycin phosphorylation (p-mTOR) and vascular endothelial growth factor (VEGF) in clear cell …
- Gastric mammalian target of Rapamycin signaling, hormone production and energy metabolism
- Rapamycin in lipoproteins for enhanced delivery
- Combined use of Rapamycin and leflunomide in prevention of acute cardiac allografts rejection in rats
- Effect of nab-Rapamycin versus Rapamycin in colorectal cancer cell lines and associations with KRAS and PI3K mutations.
- Improvement of Rapamycin fermentation with culture condition optimization and rational strain breeding
- Meta-analysis of immunosuppressive therapy with target-of-Rapamycin inhibitor instead of calcineurin inhibitor after kidney transplantation operation
- The isomerase Rrd1 mediates rapid loss of the Sgs1 helicase in response to Rapamycin
- Mammalian Target of Rapamycin
- Long-Term Maintenance Therapy for Post–Cardiac Transplant Monoclonal Lymphoproliferative Disorder: Caveat Mammalian Target of Rapamycin
- Rapamycin effect on senescence and autophagy processes in human cell lines
- Targeting the phosphatidylinosital 3-kinase, Akt, and mammalian target of Rapamycin pathway in non-small cell lung cancer
- … microenvironment, induces apoptosis, and enhances the antitumor activity of everolimus (RAD001), an inhibitor of mammalian target of Rapamycin (mTOR), in mantle …
- Rapamycin inhibits the proliferation of prostate cancer cell line 22RV1 and activity of S6K1
- Amphiphilic chitosan nanomicelles for the topical delivery of Rapamycin
- Effect of Rapamycin combined with cisplatin on head and neck squamous cancer cells regulated by CCL19
- Phosphatidykinosital 3-Kinase and Mammalian Target of Rapamycin Pathway in Non–Small-Cell Lung Cancer
- Chemosensitivity enhancement of Rapamycin on hepatocellular carcinoma and related mechanism
- Progress of Rapamycin and its derivatives in anti-tumor activity [J]
- 40‐O ‐[2‐Hydroxyethyl]Rapamycin modulates human dendritic cell function during exposure to Aspergillus fumigatus
- A phase I trial of escalating dose of the Rapamycin analog everolimus in combination with the kinase inhibitor midostaurin in patients (pts) with relapsed, refractory or …
- Rapamycin impacts positively on longevity, despite glucose intolerance induction
- Treatment of pulmonary and retroperitoneal lymphangioleiomyomatosis with Rapamycin: a case presentation and literature review
- Glycogen synthase kinase (GSK)-3 and mammalian target of Rapamycin complex 1 (mTORC1) cooperate to regulate protein S6 kinase 1 (S6K1)
- Constitutive activation of mTOR pathway by leucine causes heart hypertrophy which can be blocked by Rapamycin
- Rapamycin inhibits IL-33-induced airway inflammation
- Preclinical efficacy of AZD8055, an ATP-competitive mammalian target of Rapamycin (mTOR) kinase inhibitor, in vitro in clear cell renal cell carcinoma (RCC)
- Effects of Rapamycin and tacrolimus on mature endothelial cells and endothelial progenitor cells
- An investigation of reversal of imatinib resistance in the Bcr‐Abl positive imatinib‐resistant cell line K562r by dasatinib, nilotinib, Rapamycin and bortezomib
- Frequent activation of mammalian target of Rapamycin in primary lung adenocarcinoma and preinvasive lesion
- Role of Rapamycin in cholangiocytes regeneration after liver transplantation
- Activation of PI3K/AKT and MAPK pathway through a PDGFRb-dependent feedback loop is involved in Rapamycin resistance in hepatocellular carcinoma
- Retraction: Rapamycin-loaded nanoparticles for inhibition of neointimal hyperplasia in experimental vein grafts
- The Regulation of Mammalian Target of Rapamycin
- Dual inhibition of Phosphatidylinositol 3-Kinase and Mammalian Target of Rapamycin: a Therapeutic Strategy for Acute Leukemias.
- BI 836845, a fully human IGF ligand neutralizing antibody, to improve the efficacy of Rapamycin by blocking Rapamycin-induced AKT activation.
- Mammalian target of Rapamycin (mTOR) sigaling pathway involved in the inhibition of silence information regulator1 (Sirt1) on fat deposition of mice.
- Mdx mice have a defect in autophagy that is restored by Rapamycin‐loaded nanoparticle treatment
- Dissecting Rapamycin Responses
- Pretreatment of isolated vein with Rapamycin nanoparticles inhibits vein graft stenosis in rabbits
- Comment on “Stability of human Rapamycin-expanded CD4+ CD25+ T regulatory cells” Haematologica 2011; 96 (9): 1357–65
- Expression of mammalian target of Rapamycin in colon cancer and its effect on proliferation and apoptosis of human colon cancer HT-29 cells
- Oral Rapamycin does not mimic caloric restriction in mice
- A Burkholderia pseudomallei Mip-like protein has Rapamycin inhibitable peptidyl-prolyl isomerase activity and has pleiotropic effects on virulence
- Effects of Rapamycin on glucose metabolism and insulin resistance in obese mice [J]
- Effects of Rapamycin on growth and proliferation of human non-small cell lung cancer cell line A549
- A synthetic lethality combination with chloroquine and Rapamycin on chemosensitization
- Preparation and Release Behavior of Rapamycin-Loaded Micelles [J]
- OChiPEG micelles proven to facilitate the transscleral delivery of Rapamycin
- Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-kinase (PI3K)/mammalian Target of Rapamycin (mTOR) Dual Inhibitors
- Effects of Rapamycin on Dia2 Localization
- Rapamycin-mediated interaction of spleen γδT lymphocytes and lung macrophages in acute lung injury of mice induced by lipopolysaccharide
- Anti-aging gene klotho deficiency causes hypertension and vascular dysfunction via upregulation of mammalian target of Rapamycin (mTOR)
- Metformin and Rapamycin inhibit proliferation and alter glucose metabolism in endometrial and ovarian cancer cell lines
- Acquired Omenn-Like Syndrome, a Novel Posttransplant Autoaggression Syndrome Reversed by Rapamycin
- Rapamycin augments the NMDA-mediated TNF suppression of MRSA-stimulated RAW264. 7 murine macrophages
- Promising Activity of Mammalian Target of Rapamycin Inhibitors in Hematologic Malignancies Therapy
- Rapamycin Relieves ER Stress and Improves Function in Hearts Subjected to High Workload
- Mammalian Target of Rapamycin (mTOR) inhibition: Potential for Antiseizure, Antiepileptogenic, and Epileptostatic Therapy
- Mechanistic target of Rapamycin small interfering RNA and Rapamycin synergistically inhibit tumour growth in a mouse xenograft model of human oesophageal …
- The antitumor effect of GDC-0941 alone and in combination with Rapamycin in breast cancer cells
- inhibition of TGF-β1-induced extracellular matrix production in primary human pulmonary fibroblasts by Rapamycin
- Effects of combination treatment of Rapamycin and adriamycin on proliferation and migration of hepatoma cell BEL-7402 and their mechanisms [J]
- Progress and extensive meaning of mammalian target of Rapamycin involved in restoration of nervous system injury
- Akt/mammalian target of Rapamycin counteract the antitumor activities of cixutumumab an anti-insulin-like growth factor I receptor monoclonal antibody
- β‐hydroxy‐β‐methyl butyrate (HMB) stimulates mammalian target of Rapamycin complex 1 (mTORc1) signaling via a phosphatidylinositol‐3‐kinase (PI3K)‐dependent …
- The study on the clinical efficacy of Rapamycin eluting stent in patients with multivessel coronary disease [J]
- Rapamycin Inhibits Proliferation and Invasion of Human Bladder Carcinoma Cell Line T24 in vitro
- Rapamycin Delays Xenogeneic Acute Graft Versus Host Disease (aGVHD) in Nod/Scid/Il2RγNull (NSG) Mice: Impact of Regulatory T Cells
- Is There a Role for Mammalian Target of Rapamycin inhibition in Renal Failure due to Mesangioproliferative Nephrotic Syndrome?
- Effect of casamino acid on intergeneric conjugation in Rapamycin-producing Streptomyces hygroscopicus ATCC29253
- Does Rapamycin Still Have a Role? Experience and Lessons from the Last Decade: 1116
- Rapamycin pre-treatment abrogates Tumour Necrosis Factor-α down-regulatory effects on LXR-αand PXR mRNA expression via inhibition of c-Jun N …
- Resveratrol, Rapamycin and MG‐132 as inducers of autophagy in ARPE‐19 cells
- The Effect of Low-dose Rapamycin on Prolonging High-Risk Corneal Allograft Survival in a Mouse Model
- Rapamycin pre-treatment abrogates Tumour Necrosis Factor-a down-regulatory effects on LXR-a and PXR mRNA expression via inhibition of c-Jun N-terminal …
- Can Rapamycin Improve Cognitive Problems Caused by Chemotherapy?
- Abstract B111: Early and Delayed Rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice
- Strain Development and Optimization of Small Scale Culture Condition for Improving Rapamycin Production
- Systemic Immunomodulation with SA-FasL Protein-Engineered Donor Splenocytes Under Transient Cover of Rapamycin Induces Robust Tolerance to Cardiac …
- Rapamycin does not control hemophagocytic lymphohistiocytosis in LCMV‐infected perforin‐deficient mice
- Therapeutic effects of Rapamycin on experimental autoimmune uveoretinitis
- A feasibility study of Rapamycin with hyper-CVAD chemotherapy in adults with acute lymphoblastic leukemia (ALL) and other aggressive lymphoid malignancies and …
- Studies on inhibitory effect of Rapamycin on growth and metastasis of PC3 cells
- THE EXPRESSION OF GENES ASSOCIATED WITH OSTEOBLAST DIFFERENTIATION AND THE MAMMALIAN TARGET OF Rapamycin (mTOR) IN THE BLOOD …
- P7170, a novel inhibitor of phosphoinositide 3-kinase (PI3K)-mammalian target of Rapamycin (mTOR) and activin receptor-like kinase 1 (ALK1) as a new therapeutic …
- Hormonal and nutrient signalling to protein kinase B and mammalian target of Rapamycin in pancreatic beta-cells
- PS212. Peri-Adventitial Delivery of a Nanoparticle Albumin-Bound Rapamycin Reduces Luminal Stenosis in a Porcine Femoral Artery Balloon Injury Model
- Comparative study of immunosuppression of HuangQi glycoprotein, triptolide, Rapamycin and hydrocortisone in vitro [J]
- Effects of Rapamycin on immune function of T1DM mouse and the related molecular mechanism
- Chronic Treatment with Rapamycin Attenuates Diabetes-Associated Adverse Effects and Protects Against Myocardial Ischemia/Reperfusion Injury in Type II Diabetic …
- Role of the Mammalian Target of Rapamycin (mTOR) Signalling Pathway in Podocytes in Glomerular Disease
- TCT-601 Real-world experience of the polymer-free Rapamycin-eluting YUKON-Choice stent: five-year results from a prospective registry
- Correction: inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer’s Disease
- 1081 the number of aberrantly expressed constituents of the mammalian target of Rapamycin pathway: correlation with oncologic outcomes in clear cell renal cell …
- The FKBP-Rapamycin binding domain of human TOR undergoes strong conformational changes in the presence of membrane mimetics with and without the regulator …
- Effects of Rapamycin-induced oligomerization of parvalbumin, Stim1 and Orai1 in puncta formation
- Differential Modulation of mTORC1 and mTORC2 Signaling by Rapamycin During Pro-Arteriosclerotic Differentiation of Mesenchymal Stem Cells: 1485
- Development of mammalian target of Rapamycin inhibitors
- Translational research of the relationship between Rapamycin and hepatocellular carcinoma
- Effects of Rapamycin on the Expression of HIF-1α and VEGF in Leukemic Cell Lines SUP-B15
- NVP-BEZ235, A Dual Inhibitor of Phosphoinositol-3-Kinase (PI3K) and Mammalian Target of Rapamycin (mTOR), Is a Potent Inhibitor of Lymphoma Cell Growth and …
- Rapamycin: Advantages of Immunosuppressive Therapy with Less Neurotoxicity (P04. 166)
- Study on the Effects of Rapamycin Reverse AMN107 resistance on k562/AO2 Cells
- Activation of AMP-activated protein kinase (AMPK) enhances Radiosensitization via inhibition of mTOR pathway in Rapamycin-resistant non-small cell lung cancer …
- Neuroprotective Effect of Rapamycin in Optic Nerve Transection Model
- Rapamycin enhances chemosensitivity of endometrial cancer cells to adriamycin [J]
- Inhibitory effects of Rapamycin on proliferation of chronic myelogenous leukemia cells and its mechanism
- The Effects of Rapamycin on Endothelial Cell Migration and Vascular Endothelial Growth Factor Expression
- Oral Rapamycin prevents artery restenosis after stent implantation by inhibiting mammalian target of Rapamycin (mTOR)
- Translation of 5′ terminal oligopyrimidine tract (5′ TOP) mRNAs in Aplysia californica is regulated by the target of Rapamycin (TOR)
- S35 Rapamycin inhibits IL-33-induced, nuocyte-driven airway inflammation
- Effect of Dose and Standard Therapy on the Anti-Remodeling Effects of Rapamycin in Experimental Heart Failure
- Efficacy of the program of Rapamycin combined with CNI in chronic allograft nephropathy
- Mammalian target of Rapamycin in gastric cancer
- Rapamycin Impacts T Cell Associated Markers In A Model Of Acute Lung Injury
- 6intact plasticity and learning in Rheb1 mUtant mice: implications for Rapamycin treatments
- NF-κB Mediates Resistance to Rapamycin in Neuroblastoma
- Abstract A175: Role of MnSOD and hydrogen peroxide in Rapamycin-induced cytostasis.
- Preparation and Characterization of Rapamycin incorporated drug delivery carrier
- Study on the protective effects of Rapamycin on cerebral ischemia-reperfusion injury in rats
- STUDY OF ANTITUMOR EFFECT OF Rapamycin ON HUMAN HEPATOCELLULAR CARCINOMA HEPG-2 CELLS IN VITRO
- Low Dose Rapamycin Exacerbates Autoimmune Experimental Uveitis
- Targeting the target of Rapamycin (TOR): looking to mother nature
- Research on the pharmaceutical distribution of Rapamycin nanometer vector eye drop in rabbit eyes
- Paradoxical effect of Rapamycin on S6 phosphorylation in rats with or without seizures
- Inhibitory effects of Rapamycin on proliferation and migration of human umbilical vein endothelial cells
- Enzymatic and biochemical characterization of the Target Of Rapamycin (TOR) signaling pathway
- Effects of Rapamycin on mTOR Signaling Pathway in Human Pancreatic Cancer Cell Line SW1990
- Immunosuppressants FK506 and Rapamycin function as reversal
- Rapamycin prevents muscle growth and the increase in MHCIIa induced by voluntary wheel running
- Rapamycin aggravates experimental non alcoholic steatohepatitis in mice
- Application of macroporous adsorption resin in separation and purification of Rapamycin
- Determination of Rapamycin in blood vessel of dogs by LC-MS/MS
- Effects of Rapamycin on cholesterol homeostasis and secretory function of 3T3-L1 cells
- Mammalian target of Rapamycin: Immunosuppressive drugs
- Rapamycin increases the sensitivity of glioma-initiating cells to radiation
- Rapamycin dose-dependently promotes differentiation and cell death in an in vitro model of malignant gliomas
- … of soluble interleukine-2 receptor in blood of patients with ischemic heart disease after coronary artery angioplasty with implantation of stents with Rapamycin covering
- Inhibitory effects of Rapamycin on proliferation of chronic myelogenous leukemia cells and its mechanism
- Effects of intrathecal injection Rapamycin on neuropathic pain behaviors in mice
- The Immunosuppressive Drug Rapamycin Inhibits Several Molecular Mechanisms Involved in Tummor Development: 1648
- Role of Rapamycin-Induced Autophagy in Pancreatic B-Cell Function: 1326
- Preparation and characterization of Rapamycin nanoparticles and its effect in vein graft
- Rapamycin administration does not impair basal protein metabolism in human skeletal muscle
- Modulation of gastric nesfatin by Rapamycin
- P7170: A potent and oral phosphoinositide 3-kinase (PI3K)-mammalian target of Rapamycin (mTOR) and activin receptor-like kinase 1 (ALK1) inhibitor with anti-tumor …
- Rapamycin Reduces Reactive Oxygen Species in Cultured Human Corneal Endothelial Cells
- The role of Tacrolimus and Rapamycin on recurrence in HCC patients after liver transplantation
- Oral Rapamycin Therapy Confers Protection Against Pneumococcal Pneumonia In Young Mice
- Effect of Rapamycin inhibit liver fibrosis in rat with obstructive jaundice
- Mechanisms of Rapamycin Toxicity in Pancreatic Beta Cells
- Characterization of the Mechanistic Target of Rapamycin in the Mouse Ovary
- Mammalian target of Rapamycin inhibitors and tumor therapy
- The Role of Mammalian Target of Rapamycin in Hypertensive Rat Atria
- Abstract C225: Differential regulation of simultaneous antitumor and alloreactive CD8+ T cell responses in the same host by Rapamycin.
- Rapamycin Increases Infarct Size and is Detrimental During Acute Ischemia-Reperfusion
- Rapamycin to prevent artery restenosis after stent implantation: an intravascular ultrasound study [J]
- Effects of intrathecal injection Rapamycin on neuropathic pain bahaviors in mice: 14AP4-4
- The effects of Rapamycin on the proliferation and apoptosis of human retinal pigment epithelium cells in vitro
- Growth factor dependent regulation of p70S6 kinase: Evaluation of domain specific signals sensitive to Rapamycin
- Clinical response to intravitreal Rapamycin in a retinal neovascularization model
- Rapamycin-induced alteration of the DC maturation process sustains their capacity to induce regulatory T cells
- … The ATP-competitive mammalian target of Rapamycin (mTOR) inhibitors suppress proliferation and induce apoptosis in the acquired Rapamycin resistant breast cancer …
- Nanoparticles For Delivery Of Rapamycin To Glioblastoma And Glioblastoma-Derived Stem Cells
- Adjuvant Rapamycin Improves The Outcomes Of Severe H1N1 Pneumonia And Acute Respiratory Distress Syndrome
- Characterization of the yeast Rapamycin-sensitive phosphoproteome
- Rapamycin in patients with advanced hepatocellular carcinoma progressing on prior antiangiogenic therapy.
- Rapamycin Reduces TNF-α mRNA via Regulating 3’AU Rich Element Region
- Apoptosis of renal cells induced by TNF-α and NF-κB in diabetic rats and intervention of Rapamycin
- inhibition of Mammalian Target of Rapamycin (mTOR) in Epidermis
- Comparison of the efficacy of FK506 and Rapamycin application on liver cancer liver transplant patients after surgery
- Abstract P212: Haploinsufficiency of Target of Rapamycin Attenuates Different Forms of Cardiomyopathies in Adult Zebrafish
- Antitumor activity of Rapamycin in combination with ectopic expression of Beclin 1 in multidrug‐resistant cancer cells
- Tumor necrosis factor-related apoptosis-inducing ligand participates in injury of vascular endothelial cells induced by Rapamycin in vitro
- Advances in Technology Based on the Combination of Rapamycin and FRB Domain Mediated Protein-protein Interactions
- Structural characterization of Rapamycin and its analoges by electrospray ionization mass spectrometry
- Long-term oral delivery of encapsulated Rapamycin is not detrimental to immunity in old mice (178.11)
- Role of Rapamycin target protein signal transduction in regulating muscle volume
- Rapamycin inhibits generation of memory CD8 T cells that localize to mucosal tissues (46.23)
- Effect of Rapamycin and metformin on skin tumor promotion in mice overweight and obese
- Effects of low dosage Rapamycin on expression of the vascular endothelial growth factor in diabetic nephropathy rats
- Mammalian Target of Rapamycin Inhibitors in Breast Cancer Therapy
- Effect of Rapamycin on Filamentous Fungal Cell Walls
- Chronic Rapamycin administration maintains mitochondrial protein synthesis in heart and skeletal muscle
- Insulin-Like Peptides and the Target of Rapamycin Pathway Coordinately Regulate Blood
- Observation on the Clinical Effects of Domestic-made Rapamycin Drug-eluting Stents for Treatment of Ischemic Cardiomyopathy [J]
- Rapamycin prevents experimental sclerodermatous chronic graft-versus-host disease in mice
- Effect of Rapamycin on Aspergillus nidulans cell wall material properties
- Prediction of the course of osteoarthrosis from mTOR (mammalian target of Rapamycin) gene expression
- The influence of Rapamycin on BTLA expression of human peripheral blood T lymphocytes
- Nesfatin-1 action in the brain increases insulin sensitivity through Akt kinase/AMP-dependent protein kinase/target of Rapamycin complex 2 pathway in diet …
- Study on the effect of Rapamycin on RelB expression of immature dendritic cell
- Rapamycin Inhibits Innate and Adaptive Immune Functions of Human Plasmacytoid Dendritic Cells: 2003
- Akt/mammalian Target of Rapamycin Counteract the Akt/mammalian Target of Rapamycin Counteract the Growth Factor I Receptor Monoclonal Antibody
- Rapamycin attenuates the development of chronic hypoxia-induced pulmonary hypertension in mice
- Expression and clinical significance of phosphorylation of mammalian target protein of Rapamycin in human glioma
- Effect of Rapamycin on the cyclosporin A-resistant CD28-mediated costimulatory pathway
- Differential Rapamycin sensitivity distinguishes two distinct populations of tumor cells in murine glioma
- Rapamycin Reverses Fibrotic Differentiation Of Mesenchymal Stromal Cells From Human Lung Allografts
- Effect of Rapamycin on the expression of transforming growth factor and osteopontin in the diabetic nephropathy rats
- CD44-Tropic Polymeric Nanocarrier for Breast Cancer Targeted Rapamycin
- Effect of Rapamycin on expressions of connective tissue growth factor and fibronectin in renal interstitial fibroblasts
- The Effectiveness of Foxp3+ Treg on Carcinoma of Liver Transplantation in Tacrolimus and Rapamycin
- Separation of Rapamycin from fermentation broth using high-speed counter-current chromatography
- Collagen from Aged Mice Exposed to Short-term Caloric Restriction and Rapamycin Display Unique Properties
- Lymphoid Hyperplasia In A Patient With Common Variable Immunodeficiency Treated With Steroids And Rapamycin
- Study on the Effects of Rapamycin on Cell Proliferation, Apoptosis and Autophagy in Human Acute Lymphoblastic Cell Line SUP-B15
- EFFECTS OF INHIBITING THE MAMMALIAN TARGET OF Rapamycin (mTOR) PATHWAY AND TELOMERASE IN BREAST CANCER CELLS
- Rapamycin Causes miRNA-20a Mediated Suppression of Egln3/prolylhydroxylase-3 and Protects against Ischemia/Reperfusion Injury in Type II Diabetic Heart
- Real-time Therapeutic Window of Blood Concentration of Rapamycin in Recipients of Renal Transplantation Determined by Microparticle Enzyme Immunoassay …
- Rapamycin inhibition of TorC1 and nitrogen limitation control Gln3 and Gat1 localization by distinct regulatory pathways
- Identification of a new tumor suppressor pathway modulating Rapamycin sensitivity in colorectal cancer
- Effect of mammalian target of Rapamycin on side population cells in hepatocellular carcinoma cell line Hep3B
- Comparison of the inhibitory effect of Rapamycin and Pirarubicin on bladder cancer T24 cell [J]
- Acute Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure‐overloaded rat myocardium
- The enhancement of radio-sensitivity via autophagy induced by Rapamycin with glioma-initiating cells in vivo
- Ryanodine downregulates the expression of p-eNOS (Thr495) and improves the functions of Rapamycin treated endothelial outgrowth cells
- The effect of long-term Rapamycin treatment on hippocampal synaptic function in a mouse model of Alzheimer’s disease
- Abstract P117: Does Mammalian Target of Rapamycin Complex-2 Regulate Protein Degradation Pathways in the Heart?
- Phase I Study of Decitabine and Rapamycin in Relapsed/Refractory Acute Myelogenous Leukemia
- Five-year follow-up of China-made firebird Rapamycin drug-eluting stent in elderly patients with acute ST elevation myocardial infarction [J]
- Synergistic Effect of Flt3L and Rapamycin On Immune Tolerance Induction Via Plasmacytoid Dendritic Cells and Treg.
- Primary discuss on flow-cell elution release test method at stability of Rapamycin on drug-eluting stents
- Abnormal Retinal Ganglion Cell Activity Is Attenuated By Rapamycin In A Mouse Model Of Tuberous Sclerosis
- Target of Rapamycin Regulates Development and Ribosomal RNA Expression through Kinase Domain in Arabidopsis1 [W][OA]
- Interaction effects between AMP-activated protein kinase and mammalian target of Rapamycin signaling pathways Symbol
- The Effects of Rapamycin and Stromal Cell Derived Factor-1α on the Biological Function of Endothelial Outgrowth Cell
- The Effects of Rapamycin on Expression of Hypoxia Signal Molecules in Human Acute Myeloid Leukemic Cell Line HL-60 Under Hypoxia
- The mTOR inhibitor, Rapamycin, sensitises solid tumour cell lines to isoprenoid induced toxicity
- THE ANTI-RESTENOSIS EFFECTS OF Rapamycin AND PACLITAXEL ELUTING STENT IN SUSSCROTA DOMESTICA CORONARY ARTERY
- Transcriptional regulation of gene expression during osmotic stress responses by the mammalian target of Rapamycin
- Rapamycin and Adiponectin in Vascular Smooth Muscle Cells: Implications in the Development of Drug-Eluting Stents
- Calcineurin Inhibitor Transfer to Rapamycin Can Improve Graft Function in Living Donor Kidney Transplantation with Older Donors: 580
- Mammalian Target Of Rapamycin In Combination With Chemotherapy: Upstream Regulation Of Anaerobic Glycolysis To Target The Chemoresistant Cell Population …
- Rapamycin increased development of CD4~+ CD25~ h ighFoxp3~+ T cells of peripheral blood in liver transplant recipients
- Preparation and characterization of Rapamycin-loaded nanoemulsions as an approach for increasing anti-proliferative activity. i. phase behavior study
- The Effects Of Mitomycin, Rapamycin And Bevacizumab On Corneal Haze After Photorefractive Keratectomy
- THE mTORC1 INHIBITOR Rapamycin INDUCES A SPECIFIC PRO-INFLAMMATORY PHENOTYPE FAVORING IL-12 IN LPS-STIMULATED IMMUNE CELLS …
- Rapamycin Reduces Macrophages While Cyclosporine A Reduces Neutrophils In The Retina In Mouse Endotoxin-induced Uveitis
- Preemptive Use of Mammalian Target of Rapamycin Inhibitors in Living Donor Transplantation
- Role of Rapamycin in protection against cerebral ischemia-induced brain injury is related to neurogenesis in discrete brain regions in rat
- Rapamycin prolongs overall survival and progression-free survival in a mouse model of lung cancer in never smokers resistant to erlotinib
- … imaging of kidney cysts: volumetric assessment in patients affected by autosomal dominant polycystic kidney disease (ADPKD) type I in treatment with Rapamycin
- Perifosine inhibits growth of Rapamycin resistant cells through activating GSK3β
- Rapamycin and Podocyte Apoptosis/Injury in Renal Allograft Biopsies: 2290
- Application of Rapamycin-Eluting Stent with Biodegradable Polymer Coating in Patients Receiving Emergency Percutaneous Coronary Intervention
- Rapamycin is a Deceptive Tool for Probing Functional Interactions Between FK506-Binding Proteins and Ryanodine Receptors
- Rapamycin inhibits lymph node metastasis in an orthotopic model of head and neck squamous cell carcinoma: A possible role for a suppression of VEGFR-3 …
- Mammalian Target of Rapamycin and Tristetraprolin Regulate Iron Homeostasis in Cardiac Cells
- Cytotoxic and cystostatic properties of Rapamycin are due to differential effects on the phosphorylation of mTORC1 substrates S6 kinase and 4E-BP1
- The differential effects of prenatal and/or postnatal Rapamycin on neurodevelopmental defects and cognition in a neuroglial mouse model of tuberous sclerosis …
- ARABIDOPSIS LST8 proteins interact with target of Rapamycin and over-expression of LST8 results in plants being hypersensitive to light
- Study on autophagy induced by Rapamycin in melanoma cell line M14 and changes in the expression of Bcl-2 and Bax in progress of autophagy
- Mammalian target of Rapamycin (mTOR) inhibitors in pediatric kidney transplantation: A systematic review
- The Effect of Rapamycin Paired with Traumatic Memory Activation on Cognitive Performance in Veterans Diagnosed with PTSD
- Mammalian Target of Rapamycin (mTOR) inhibition Attenuates Angiotensin II-Induced Hypertension and Endothelial Dysfunction
- Rapamycin Treatment Shifts Balance of Autophagy and Apoptosis during Murine Cytomegalovirus (MCMV) Infection of the Retina or RPE Cells
- Combination of Rapamycin with sorafenib as a therapeutic strategy against colorectal cancers with mutational activation of KRAS and PIK3CA
- Abstract A75: Calorie restriction and Rapamycin, but not exercise, inhibit mammary tumor growth in a mouse model of postmenopausal obesity
- Regulatory role of the mechanistic target of Rapamycin (mTOR) on the expression of osmotic stress response genes in mammalian cells
- Effect Of Rapamycin And IL-2 On Regulatory CD4+ CD25+ Foxp3+ T Cells In Mice After Allogenic Penetrating Keratoplasty
- Why is Rapamycin effective against Kaposi sarcoma? An analysis of molecular pathways reveals posttranslational silencing of PTEN
- Interaction between the rabphillin-3A-like gene and phosphorylation of mammalian target of Rapamycin (mTOR) in colorectal cancer
- Rapamycin increased development of CD4+ CD25high Foxp3+ T cells of peripheral blood in liver transplant recipients
- Enhancement of the long term efficacy of BCG vaccine against experimental tuberculosis in mice through Rapamycin induced modulation of CD4 and CD8 T cell …
- Heterogeneity In Responsiveness Of Mesenchymal Stromal Cell From Individual IPF Patients To mTOR Inhibitor Rapamycin And Its Correlation To Dysregulation In …
- Efficacy of homemade biodegradable Rapamycin drug-eluting stent implantation: Compared with bare-metal stents
- Glutamine starvation and Rapamycin inhibition of TorC1 elicit transcription of distinct groups of nitrogen‐responsive genes
- Preclinical efficacy of AZD8055, an ATP-competitive mammalian target of Rapamycin (mTOR) kinase inhibitor, in vitro in urothelial carcinoma of the bladder
- Effects of RhoC-siRNA combined with Rapamycin on invasion and metastasis of hepatocellular carcinoma cell Bel7402
- Resistance to silvestrol is mediated by MDR1/Pgp over-expression in a lymphoblastic leukemia cell line and is reversible by treatment with Rapamycin
- Identification of interacting partners of mammalian target of Rapamycin complex 1 (mTORC1) assembly in human lymphocytes
- Statins and Rapamycin synergistically induce dendritic cell KLF2 expression and tolerogenic function in vivo (P1610)(56.8)
- Chronic Rapamycin Treatment Causes a Deficit in Optokinetic Tracking in Male Mice and Does Not Prevent Tracking Deficits in the Ins2Akita Mouse Model of Diabetic …
- inhibition of mammalian target of Rapamycin (mTOR) signaling by Temsirolimus as a potential therapeutic strategy for esophageal cancer treatment
- PIM kinase inhibition blocks activation of mTOR pathway components and enhances Rapamycin-mediated tumor growth inhibition in prostate cancers
- Evaluation of polymer-free paclitaxel-eluting stents versus biodegradable polymer-based Rapamycin-eluting stents in treatment with coronary heart disease
- Mammalian target of Rapamycin regulate kidney oxygen consumption by controlling mitochondrial function via regulation of uncoupling protein 2
- Mammalian Target of Rapamycin Regulates Cardiac Iron Homeostasis in vitro and in vivo through Modulation of Tristetraprolin Expression
- Functional analysis of the single Est1/Ebs1 homologue in K. lactis reveals roles in both telomere maintenance and Rapamycin resistance
- Abstract P6-11-03: Site-Specific, Concomitant Delivery of Rapamycin and Paclitaxel in Breast Cancer: Consequent Synergistic Efficacy Enhancement
- Amino Acids and Insulin are Both Necessary for an Amplified Response of Protein Synthesis Through the Mammalian Target of Rapamycin Signaling Pathway
- Selective ATP-competitive inhibitors of TOR suppress Rapamycin insensitive function of Torc2 in S. cerevisae
- WITHDRAWN: Mammalian target of Rapamycin (mTOR) inhibition in polycystic kidney disease (PKD): From bench to bedside
- P-459 Role of the mammalian target of Rapamycin (mTOR) during human follicular development
- IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ-Dependent Apoptosis of Alloreactive CD4+ T Cells and Limit Graft-Versus-Host Diseas
- Genetic variants in the mammalian target of Rapamycin (mTOR) signaling pathway as predictors of clinical response and survival in women with ovarian cancer
- Re: Mammalian Target of Rapamycin (mTOR) Regulates Cellular Proliferation and Tumor Growth in Urothelial Carcinoma
- Dual-frequency ultrasound-mediated delivery of Rapamycin from microbubbles decreases drug dose needed to reduce neointima formation in vivo
- In vitro profibrotic effects of Rapamycin on basal or TGF-β1 induced primary human lung fibroblast: ECM production and turnover, migration and differentiation
- Immune Blot Analysis on Expression of the Mammalian Target of Rapamycin in Goat Fetal Fibroblasts with Recombinant Polyclonal Antibody
- Abstract LB-7: HPV-associated HNSCC: widespread mTOR pathway activity and preclinical evaluation of mTOR inhibitors Rapamycin and RAD-001
- Oral Rapamycin to Reduce Intimal Hyperplasia After Bare Metal Stent Implantation-A Prospective Randomized Intravascular Ultrasound Study
- The mammalian target of Rapamycin complex 2 (mTORC2) negatively regulates the innate inflammatory response
- Tacrolimus and Rapamycin do not elevate cholesterol synthesis in post‐transplant patients, but may impair response to multi‐nutrient dietary intervention
- First report of a novel abluminal groove filled biodegradable polymer Rapamycin-eluting stent inde novocoronary artery disease: results of the first in man FIREHAWK …
- Can negative biomarkers be helpful? A novel combination test to predict non-response to inhibition of the mammalian target of Rapamycin (mTOR) pathway in …
- … Therapeutic Potential of Targeting Dysregulated Signaling Axes in Squamous Cell Carcinoma: Another Kinase of Transcription and Mammalian Target of Rapamycin
- Genetic variants in the mammalian target of Rapamycin (mTOR) signaling pathway as predictors of survival and clinical response in women with ovarian cancer
- Re: Hypoxia-Inducible Factor and Mammalian Target of Rapamycin Pathway Markers in Urothelial Carcinoma of the Bladder: Possible Therapeutic Implications
- Rapamycin-insensitive mTORC1 activity controls eIF4E: 4E-BP1 binding [version 1; referees: 3 approved]
- Combination of LC3 II shRNA and genistein completely inhibited Rapamycin-induced autophagy and promoted apoptosis in human malignant neuroblastoma cell lines
- Rapamycin Enhances Protective Effect of Sildenafil against Doxorubicin Cardiotoxicity and Potentiates Cancer Cell Killing
- … type CD8+ t-cells correlates with the failure of early immunosuppression withdrawal after cadaver liver transplantation using high doses atg induction and Rapamycin
- P158 All-trans retinoic acid and Rapamycin synergize with transforming growth factor-B to induce regulatory T cells but confer distinct in vivo migratory capacities
- IL-12hi Rapamycin-Conditioned Dendritic Cells Induce Apoptosis of Alloreactive CD4+ T Cells in an Ifn-γ-Dependent Manner and Inhibit Graft-Versus-Host Disease
- Mammalian target of Rapamycin (mTOR) signaling proteins are highly expressed in mamamry tumors of MMTV-TGF-β mice
- NOVEL INSIGHTS INTO BONE MORPHOGENETIC PROTEIN (BMP) AND MAMMALIAN TARGET OF Rapamycin (mTOR) SIGNALING AXIS IN PROSTATE …
- To assess coronary atherosclerotic plaque by IVUS-VH and the level of hs-CRP in serum, to observe is involved Rapamycin-eluting in-stent restenosis
- A Stable Chitosan-coated Nanomicelle Combination Of Vitamin E-TPGS And Cholesterol-PEG For The Topical Administration And Scleral Retention Of Rapamycin
- Risk of rash and stomatitis with everolimus, a mammalian target of Rapamycin (mTOR) inhibitor: A meta-analysis.
- Selective ATP-competitive inhibitors of TOR suppress Rapamycin insensitive function of TORC2 in S. cerevisiae
- P94 Rapamycin helps maintain the regulatory phenotype of cytochrome P450IID6-specific Treg expanded from patients with autoimmune hepatitis type 2 by reducing …
- Mammalian Target of Rapamycin Inhibitor and Anti-Death Receptor Agonistic Antibody: a Novel Combination Therapy for the Treatment of Hepatocellular Carcinoma …
- A Global Kinase and Phosphatase Interaction Network in the Budding Yeast Reveals Novel Effectors of the Target of Rapamycin (TOR) Pathway
- CD4 T helper cell profiling in heart and liver transplant recipients: Comparison between CNI-, Rapamycin-and anti-CD25 mAB-based immunosuppression
- Rapamycin Eluting Biodegradable Extravascular Stent Prevents Vein Graft Stenosis at Long Term in a Canine Model
- Risk of rash and stomatitis with temsirolimus, a mammalian target of Rapamycin (mTOR) inhibitor: A meta-analysis.
- Differential effects of Rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ Treg subpopulations
- Combined grape polyphenols regulate mammalian target of Rapamycin (mTOR) signaling via a dual mechanism of Akt inhibition and AMPK activation
- ET-04. COMBINED MYXOMA VIROTHERAPY WITH Rapamycin TARGETING BRAIN TUMOR-INITIATING CELLS
- Mammalian Target of Rapamycin Signal Inhibitors (imTOR) Use in First and Relapse BK Polyomavirus Nephritis (BKVN) in Renal Allograft Recipients: 2556
- Adventitial Nab-Rapamycin Injection Reduces Porcine Femoral Artery Luminal Stenosis Induced by Balloon Angioplasty via inhibition of Medial Proliferation and …
- IL-12 combined with Rapamycin enhances the ellular immunity induced by PRRS attenuated vaccine
- UCHL1 protein synthesis upon Rapamycin treatment involves its antisense RNA trough embedded SINEB2 repeat
- Evaluation of NIH-Defined Chronic Graft-Versus-Host-Disease in a Rapamycin-Based Haploidentical Stem Cell Transplantation: Analysis of 113 Consecutive Patients …
- The Internal Ribosome Entry Site-Medaited Expression of VEGF Rescues HS Sultan Tumor Cells From Mammalian Target of Rapamycin (mTOR)-Inhibitors Induced …
- Comparison between Oral Rapamycin Plus Bare Metal Stent versus Drug Eluting Stent for the Prevention of Restenosis in the Treatment of Coronary Disease with …
- Rapamycin delays xenogeneic acute graft-versus-host disease (aGvHD) in NOD/SCID/IL2Rg NULL (NSG) mice: impact of regulatory T cells
- Effects of 1-methyl-4-phenyl pyridinium on mammalian Rapamycin target signaling pathway in human neuroblastoma cells
- 1070 DEVELOPMENT OF A Rapamycin SENSITIVE CELL LINE FROM UROTHELIAL CARCINOMA WITH SARCOMATOID FEATURES
- The mTOR inhibitor Rapamycin delays xenogeneic acute graft versus host disease (aGVHD) in NOD/SCID/IL2rgnull mice (NSG): impact of regulatory T cells
- … CELLS AGAINST HYPOXIA AND SERUM DEPRIVATION-INDUCED APOPTOSIS VIA AMP-ACTIVATED PROTEIN KINASE/MAMMALIAN TARGET OF Rapamycin …
- Mammalian Target of Rapamycin Inhibitors Versus Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitors (VEGF TKI) as Second-Line Therapy in …
- Marinobufagenin induced uremic cardiomyopathy: the role of passive immunization, Rapamycin, and CD40 signaling in the generation of renal fibrosis
- inhibition of Mammalian Target of Rapamycin (mTOR) Complex 1 and 2 by PP242 Induces G1 Growth Arrest in Pancreatic Ductal Adenocarcinoma and when …
- Preconditioning with Rapamycin and CTLA4-Ig in Dogs Given Donor Antigen and 1Gy Total Body Irradiation (TBI) Before Dog-Leukocyte-Antigen (DLA)-Identical …
- Rapamycin: one drug, many effects
- Duration of Rapamycin treatment has differential effects on metabolism in mice
- Rapamycin extends life and health in C57BL/6 mice
- Longevity, aging and Rapamycin
- Rapamycin unbalances the polarization of human macrophages to M 1
- Rapamycin extends murine lifespan but has limited effects on aging
- Mammalian target of Rapamycin signaling in cardiac physiology and disease
- Evidence for Rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms
- The role of target of Rapamycin signaling networks in plant growth and metabolism
- Rapamycin, autophagy, and Alzheimer’s disease
- mTORC1 phosphorylation sites encode their sensitivity to starvation and Rapamycin
- Rapamycin extends life-and health span because it slows aging
- Rapamycin inhibits the growth of glioblastoma
- Late‐life Rapamycin treatment reverses age‐related heart dysfunction
- Rapamycin and aging: when, for how long, and how much?
- Mammalian target of Rapamycin (mTOR) pathways in neurological diseases
- Rapamycin increases survival in ALS mice lacking mature lymphocytes
- MIR181A regulates starvation- and Rapamycin-induced autophagy through targeting of ATG5
- A diverse array of cancer-associated mTOR mutations are hyperactivating and can predict Rapamycin sensitivity
- Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
- Mammalian target of Rapamycin (mTOR) inhibition with Rapamycin improves cardiac function in type 2 diabetic mice: potential role of attenuated oxidative …
- Large FK506-binding proteins shape the pharmacology of Rapamycin
- Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injury
- Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice
- Systemic analysis of inducible target of Rapamycin mutants reveal a general metabolic switch controlling growth in Arabidopsis thaliana
- Mechanistic target of Rapamycin complex 2 protects the heart from ischemic damage
- Mice fed Rapamycin have an increase in lifespan associated with major changes in the liver transcriptome
- RAB3GAP1 and RAB3GAP2 modulate basal and Rapamycin-induced autophagy
- Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation
- Altered proteome turnover and remodeling by short‐term caloric restriction or Rapamycin rejuvenate the aging heart
- Rapamycin allosterically inhibits the proteasome
- Activation of mammalian target of Rapamycin and synaptogenesis: role in the actions of rapid-acting antidepressants
- Induced regulatory T cells promote tolerance when stabilized by Rapamycin and IL-2 in vivo
- Sugar metabolism and the plant target of Rapamycin kinase: a sweet operaTOR?
- Therapeutic effects of Rapamycin on MPTP-induced Parkinsonism in mice
- Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke
- Rapamycin is neuroprotective in a rat chronic hypertensive glaucoma model
- Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells
- Rapamycin alleviates cisplatin-induced ototoxicity in vivo
- Mutations in mammalian target of Rapamycin regulator DEPDC5 cause focal epilepsy with brain malformations
- Rapamycin induces ILT3highILT4high dendritic cells promoting a new immunoregulatory pathway
- Co-delivery of cisplatin and Rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation
- Preserving youth: does Rapamycin deliver?
- Mammalian target of Rapamycin inhibition in hepatocellular carcinoma
- Convergence of ubiquitylation and phosphorylation signaling in Rapamycin-treated yeast cells
- Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder
- The role of mechanistic target of Rapamycin (mTOR) complexes signaling in the immune responses
- Mammalian target of Rapamycin inhibitor-associated stomatitis
- Scopolamine rapidly increases mammalian target of Rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses
- Local intra-articular injection of Rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis
- Rapamycin-induced metabolic defects are reversible in both lean and obese mice
- Chronic Rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s …
- Taking aim at Alzheimer’s disease through the mammalian target of Rapamycin
- Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension
- Driving neural regeneration through the mammalian target of Rapamycin
- Metabolomic response of Chlamydomonas reinhardtii to the inhibition of target of Rapamycin (TOR) by Rapamycin
- Rapamycin rescues ABT-737 efficacy in small cell lung cancer
- Chronic Rapamycin treatment causes diabetes in male mice
- Mammalian target of Rapamycin inhibitors are associated with lower rates of hepatocellular carcinoma recurrence after liver transplantation: a systematic review
- Weekly administration of Rapamycin improves survival and biomarkers in obese male mice on high‐fat diet
- Hepatic signaling by the mechanistic target of Rapamycin complex 2 (mTORC2)
- Rapamycin encapsulated in dual-responsive micelles for cancer therapy
- Molecular determinants of outcome with mammalian target of Rapamycin inhibition in endometrial cancer
- Rapamycin, anti-aging, and avoiding the fate of Tithonus
- Molecular and genetic crosstalks between mTOR and ERRα are key determinants of Rapamycin-induced nonalcoholic fatty liver
- Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson’s disease
- Short-term treatment with Rapamycin and dietary restriction have overlapping and distinctive effects in young mice
- Rapamycin extends life span of Rb1+/− mice by inhibiting neuroendocrine tumors
- Differential effects of Rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+ CD25+ FOXP3+ T regulatory cell …
- Rapamycin suppresses brain aging in senescence-accelerated OXYS rats
- Sustained inhibition of receptor tyrosine kinases and macrophage depletion by PLX3397 and Rapamycin as a potential new approach for the treatment of MPNSTs
- Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage
- Mammalian target of Rapamycin (mTOR) mediates tau protein dyshomeostasis: implication for Alzheimer disease
- Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium
- Mechanistic target of Rapamycin controls homeostasis of adipogenesis
- Rapamycin limits the growth of established experimental abdominal aortic aneurysms
- Lamins are Rapamycin targets that impact human longevity: a study in centenarians
- Multifaceted effects of Rapamycin on functional recovery after spinal cord injury in rats through autophagy promotion, anti-inflammation, and neuroprotection
- A systematic review of conversion from calcineurin inhibitor to mammalian target of Rapamycin inhibitors for maintenance immunosuppression in kidney transplant …
- Beneficial metabolic effects of Rapamycin are associated with enhanced regulatory cells in diet-induced obese mice
- Mechanistic target of Rapamycin (mTOR) is essential for murine embryonic heart development and growth
- Mammalian target of Rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury
- Cell cycle regulation by the nutrient-sensing mammalian target of Rapamycin (mTOR) pathway
- Mammalian target of Rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination
- Enhancing autophagy with activated protein C and Rapamycin protects against sepsis-induced acute lung injury
- (R,S)-Ketamine Metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine Increase the Mammalian Target of Rapamycin Function
- Mechanistic target of Rapamycin inhibition extends cellular lifespan in dendritic cells by preserving mitochondrial function
- Different patterns of Akt and ERK feedback activation in response to Rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells
- Contact inhibition and high cell density deactivate the mammalian target of Rapamycin pathway, thus suppressing the senescence program
- High‐dose Rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy
- Rapamycin treatment improves neuron viability in an in vitro model of stroke
- Genetic reduction of mammalian target of Rapamycin ameliorates Alzheimer’s disease-like cognitive and pathological deficits by restoring hippocampal gene …
- Nitrogen source activates TOR (target of Rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins
- The use of sirolimus (Rapamycin) in the management of refractory inflammatory bowel disease in children
- RETRACTED: Rapamycin induces of protective autophagy in vascular endothelial cells exposed to oxygen–glucose deprivation
- Weekly nab-Rapamycin in patients with advanced nonhematologic malignancies: final results of a phase I trial
- M (o) TOR of pseudo-hypoxic state in aging: Rapamycin to the rescue
- Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2
- Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of Rapamycin (mTOR)
- Mechanistic target of Rapamycin complex 1 expands Th17 and IL-4+ CD4− CD8− double-negative T cells and contracts regulatory T cells in systemic lupus …
- Rapamycin upregulates autophagy by inhibiting the mTOR-ULK1 pathway, resulting in reduced podocyte injury
- Colocalized delivery of Rapamycin and paclitaxel to tumors enhances synergistic targeting of the PI3K/Akt/mTOR pathway
- Reduced mammalian target of Rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts
- Assessment of mitochondrial biogenesis and mTORC1 signaling during chronic Rapamycin feeding in male and female mice
- Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice
- A unique herpesviral transcriptional program in KSHV-infected lymphatic endothelial cells leads to mTORC1 activation and Rapamycin sensitivity
- Mammalian target of Rapamycin as a rational therapeutic target for breast cancer treatment
- Rapamycin decreases tau phosphorylation at Ser214 through regulation of cAMP-dependent kinase
- mTOR signaling in liver regeneration: Rapamycin combined with growth factor treatment
- Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells
- Low-dose Rapamycin (sirolimus) effects in autosomal dominant polycystic kidney disease: an open-label randomized controlled pilot study
- Disruption of mammalian target of Rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis
- Mechanistic target of Rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus
- Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by Rapamycin
- A feasibility and efficacy study of Rapamycin and erlotinib for recurrent pediatric low‐grade glioma (LGG)
- Targeted radiotherapy of prostate cancer with a gastrin-releasing peptide receptor antagonist is effective as monotherapy and in combination with Rapamycin
- Antidepressant-like effect of ascorbic acid is associated with the modulation of mammalian target of Rapamycin pathway
- Acute systemic Rapamycin induces neurobehavioral alterations in rats
- Mammalian target of Rapamycin inhibitors for intractable epilepsy and subependymal giant cell astrocytomas in tuberous sclerosis complex
- Effects of the mTOR inhibitor Rapamycin on monocyte-secreted chemokines
- Efficacy of Rapamycin against glioblastoma cancer stem cells
- Mammalian target of Rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells
- Periadventitial application of Rapamycin-loaded nanoparticles produces sustained inhibition of vascular restenosis
- Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of Rapamycin (mTOR) inhibition
- Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy
- Mammalian target of Rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial …
- Topical Rapamycin for angiofibromas in paediatric patients with tuberous sclerosis: follow up of a pilot study and promising future directions
- Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke
- Rapamycin and everolimus facilitate hepatitis E virus replication: revealing a basal defense mechanism of PI3K-PKB-mTOR pathway
- Mechanistic target of Rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function
- Correction of glycogen storage disease type III with Rapamycin in a canine model
- Mammalian target of Rapamycin and its downstream signalling components are activated in psoriatic skin
- First left–right comparative study of topical Rapamycin vs. vehicle for facial angiofibromas in patients with tuberous sclerosis complex
- Reprogramming of the microRNA transcriptome mediates resistance to Rapamycin
- The role of diacylglycerol kinase ζ and phosphatidic acid in the mechanical activation of mammalian target of Rapamycin (mTOR) signaling and skeletal …
- Mammalian target of Rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer’s disease pathology
- Metabolic control by target of Rapamycin and autophagy during ageing-a mini-review
- Rapamycin improves sociability in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders
- Inducing autophagy: a comparative phosphoproteomic study of the cellular response to ammonia and Rapamycin
- Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function
- Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence
- Effects of Rapamycin combined with low dose prednisone in patients with chronic immune thrombocytopenia
- Rheb and mammalian target of Rapamycin in mitochondrial homoeostasis
- Role of Akt and mammalian target of Rapamycin in functional outcome after concussive brain injury in mice
- Conversion to mammalian target of Rapamycin inhibitors increases risk of de novo donor‐specific antibodies
- Intra-articular administration of gelatin hydrogels incorporating Rapamycin–micelles reduces the development of experimental osteoarthritis in a murine model
- Rapamycin rescues the poor developmental capacity of aged porcine oocytes
- A Rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren’s …
- Prenatal Rapamycin results in early and late behavioral abnormalities in wildtype C57BL/6 mice
- Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression
- inhibition of mammalian target of Rapamycin with Rapamycin reverses hypertrophic cardiomyopathy in mice with cardiomyocyte-specific knockout of PTEN
- Skeletal muscle-derived myonectin activates the mammalian target of Rapamycin (mTOR) pathway to suppress autophagy in liver
- Combined treatment of Rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver
- Protection Against Epithelial Damage During Candida albicans Infection Is Mediated by PI3K/Akt and Mammalian Target of Rapamycin Signaling
- Insulin and Target of Rapamycin signaling orchestrate the development of ovarian niche-stem cell units in Drosophila
- Neuroprotective effects of autophagy induced by Rapamycin in rat acute spinal cord injury model
- Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
- Isoleucine, leucine, methionine, and threonine effects on mammalian target of Rapamycin signaling in mammary tissue
- The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of Rapamycin on human neuroendocrine tumors
- Rapamycin prevents drug seeking via disrupting reconsolidation of reward memory in rats
- Target of Rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration
- Adjuvant treatment with a mammalian target of Rapamycin inhibitor, sirolimus, and steroids improves outcomes in patients with severe H1N1 pneumonia and acute …
- Rapamycin inhibits the mTOR/p70S6K pathway and attenuates cardiac fibrosis in adriamycin-induced dilated cardiomyopathy
- Mechanism of metformin-dependent inhibition of mammalian target of Rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) …
- Beyond control of protein translation: what we have learned about the non-canonical regulation and function of mammalian target of Rapamycin (mTOR)
- Mammalian target of Rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function
- Dihydroartemisinin inhibits the mammalian target of Rapamycin-mediated signaling pathways in tumor cells
- The rationale of targeting mammalian target of Rapamycin for ischemic stroke
- Beneficial role of Rapamycin in experimental autoimmune myositis
- MicroRNA-199a-3p regulates endometrial cancer cell proliferation by targeting mammalian target of Rapamycin (mTOR)
- Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of Rapamycin (mTOR) pathway, through endoplasmic reticulum stress to induce …
- Rapamycin has a beneficial effect on controlling epilepsy in children with tuberous sclerosis complex: results of 7 children from a cohort of 86
- The role of mammalian target of Rapamycin inhibitors in the management of post‐transplant malignancy
- Differences in Mammalian target of Rapamycin gene expression in the peripheral blood and articular cartilages of osteoarthritic patients and disease activity
- Proteasome-dependent activation of mammalian target of Rapamycin complex 1 (mTORC1) is essential for autophagy suppression and muscle remodeling …
- Current models of mammalian target of Rapamycin complex 1 (mTORC1) activation by growth factors and amino acids
- microRNA‑199a is able to reverse cisplatin resistance in human ovarian cancer cells through the inhibition of mammalian target of Rapamycin
- RhoA modulates signaling through the mechanistic target of Rapamycin complex 1 (mTORC1) in mammalian cells
- Rapamycin inhibition of polyposis and progression to dysplasia in a mouse model
- The immunosuppressive agents Rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid …
- Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of Rapamycin) by IκB kinase α (IKKα)
- Differential effects of Rapamycin and dexamethasone in mouse models of established allergic asthma
- Antitumor effects of Rapamycin in pancreatic cancer cells by inducing apoptosis and autophagy
- Rapamycin and omega‐1: mTOR‐dependent and‐independent Th2 skewing by human dendritic cells
- Rapamycin inhibits FBXW7 loss-induced epithelial–mesenchymal transition and cancer stem cell-like characteristics in colorectal cancer cells
- Rapamycin resistance: mTORC1 substrates hold some of the answers
- Mammalian target of Rapamycin regulates IL-10 and resistance to Pseudomonas aeruginosa corneal infection
- Prolonged Rapamycin treatment led to beneficial metabolic switch
- Blockade of mTOR signaling via Rapamycin combined with immunotherapy augments antiglioma cytotoxic and memory T-cell functions
- Ribosomal protein S6, a target of Rapamycin, is involved in the regulation of rRNA genes by possible epigenetic changes in Arabidopsis
- PML mediates glioblastoma resistance to mammalian target of Rapamycin (mTOR)-targeted therapies
- Rapamycin inhibits ALDH activity, resistance to oxidative stress, and metastatic potential in murine osteosarcoma cells
- TGF-β/Smad3 activates mammalian target of Rapamycin complex-1 to promote collagen production by increasing HIF-1α expression
- Successful treatment of subungual fibromas of tuberous sclerosis with topical Rapamycin
- Laser phototherapy accelerates oral keratinocyte migration through the modulation of the mammalian target of Rapamycin signaling pathway
- PPARγ activation attenuates glucose intolerance induced by mTOR inhibition with Rapamycin in rats
- Activation of mammalian target of Rapamycin signaling in skeletal muscle of neonatal chicks: Effects of dietary leucine and age
- Single Rapamycin administration induces prolonged downward shift in defended body weight in rats
- Comparison of Rapamycin schedules in mice on high-fat diet
- Inhalable Particles Containing Rapamycin for Induction of Autophagy in Macrophages Infected with Mycobacterium tuberculosis
- SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of Rapamycin signaling
- Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating Rapamycin-induced Akt phosphorylation
- Cross-talk between sirtuin and mammalian target of Rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation
- A novel topical Rapamycin cream for the treatment of facial angiofibromas in tuberous sclerosis complex
- Rapamycin inhibits the production of myofibroblasts and reduces corneal scarring after photorefractive keratectomy
- Fluorescence tomography of Rapamycin-induced autophagy and cardioprotection in vivo
- Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a)
- Mechanistic target of Rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer …
- Targeting the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of Rapamycin (mTOR) pathway: an emerging treatment strategy for squamous cell lung …
- Bone effects of mammalian target of Rapamycin (mTOR) inhibition with everolimus
- Rapamycin increases mitochondrial efficiency by mtDNA-dependent reprogramming of mitochondrial metabolism in Drosophila
- A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and Rapamycin
- inhibition of mammalian target of Rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat
- Resveratrol prevents Rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells
- Combined SFK/mTOR inhibition prevents Rapamycin-induced feedback activation of AKT and elicits efficient tumor regression
- Topical Rapamycin as a treatment for fibrofolliculomas in Birt-Hogg-Dubé syndrome: a double-blind placebo-controlled randomized split-face trial
- Mammalian target of Rapamycin cell signaling pathway contributes to the protective effects of ischemic postconditioning against stroke
- Combination of autophagy inducer Rapamycin and oncolytic adenovirus improves antitumor effect in cancer cells
- Effects of AMP-activated protein kinase (AMPK) signaling and essential amino acids on mammalian target of Rapamycin (mTOR) signaling and protein …
- Chemical injury-induced corneal opacity and neovascularization reduced by Rapamycin via TGF-β1/ERK pathways regulation
- Comparative metabolic profiling-based improvement of Rapamycin production by Streptomyces hygroscopicus
- Anti-remodeling effects of Rapamycin in experimental heart failure: dose response and interaction with angiotensin receptor blockade
- Treating brain tumor–initiating cells using a combination of myxoma virus and Rapamycin
- Superiority of Rapamycin over tacrolimus in preserving nonhuman primate Treg half‐life and phenotype after adoptive transfer
- Anti-angiogenic effects of mammalian target of Rapamycin inhibitors in a mouse model of oxygen-induced retinopathy
- Topical Rapamycin (sirolimus) for facial angiofibromas
- Mammalian target of Rapamycin signaling is involved in the vasculogenic mimicry of glioma via hypoxia-inducible factor-1α
- Systemic inhibition of mTOR kinase via Rapamycin disrupts consolidation and reconsolidation of auditory fear memory
- The antiaging activity and cerebral protection of Rapamycin at micro‐doses
- Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN‐deficient human fibroblasts
- Acute Rapamycin treatment improved glucose tolerance through inhibition of hepatic gluconeogenesis in rainbow trout (Oncorhynchus mykiss)
- Amino acids activate mammalian target of Rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging
- Mammalian target of Rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion
- The general control nonderepressible‐2 kinase mediates stress response and longevity induced by target of Rapamycin inactivation in Caenorhabditis elegans
- The incidence, management, and evolution of Rapamycin‐related side effects in kidney transplant recipients
- Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of Rapamycin (mTOR)
- Comparative Study of Rapamycin and Temsirolimus Demonstrates Superimposable Anti‐Tumour Potency on Prostate Cancer Cells
- Rapamycin ameliorates inflammation and fibrosis in the early phase of cirrhotic portal hypertension in rats through inhibition of mTORC1 but not mTORC2
- Behavioural and EEG effects of chronic Rapamycin treatment in a mouse model of tuberous sclerosis complex
- The mammalian target of Rapamycin signalling pathway is involved in osteoblastic differentiation of vascular smooth muscle cells
- Subcellular distribution and activity of mechanistic target of Rapamycin in aged retinal pigment epithelium
- LY294002 and Rapamycin promote coxsackievirus-induced cytopathic effect and apoptosis via inhibition of PI3K/AKT/mTOR signaling pathway
- inhibition of mammalian target of Rapamycin aggravates the respiratory burst defect of neutrophils from decompensated patients with cirrhosis
- Mammalian target of Rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformations
- Rapamycin attenuates bleomycin-induced pulmonary fibrosis in rats and the expression of metalloproteinase-9 and tissue inhibitors of metalloproteinase-1 in lung …
- Mammalian target of Rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton
- Combined mTOR inhibitor Rapamycin and doxorubicin-loaded cyclic octapeptide modified liposomes for targeting integrin α3 in triple-negative breast cancer
- Phosphorylated mammalian target of Rapamycin is associated with an adverse outcome in oral squamous cell carcinoma
- Rapamycin alleviates brain edema after focal cerebral ischemia reperfusion in rats
- Alternative mammalian target of Rapamycin (mTOR) signal activation in sorafenib-resistant hepatocellular carcinoma cells revealed by array-based pathway …
- … resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of Rapamycin, protein kinase B, or …
- Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages
- Transcriptional profiling of Rapamycin-treated fibroblasts from hypertrophic and keloid scars
- p53/TAp63 and AKT regulate mammalian target of Rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of …
- Young and old genetically heterogeneous HET 3 mice on a Rapamycin diet are glucose intolerant but insulin sensitive
- Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated …
- Rapamycin-mediated CD36 translational suppression contributes to alleviation of hepatic steatosis
- Pan-mammalian target of Rapamycin (mTOR) inhibitor AZD8055 primes rhabdomyosarcoma cells for ABT-737-induced apoptosis by down-regulating Mcl-1 …
- Rapamycin treatment of Mandibuloacral dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamics
- Chemical inhibitors and microRNAs (miRNA) targeting the mammalian target of Rapamycin (mTOR) pathway: potential for novel anticancer therapeutics
- … characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic Rapamycin treatment
- Impairing the production of ribosomal RNA activates mammalian target of Rapamycin complex 1 signalling and downstream translation factors
- inhibition of the mammalian target of Rapamycin leads to autophagy activation and cell death of MG63 osteosarcoma cells
- Rapamycin-induced autophagy aggravates pathology and weakness in a mouse model of VCP-associated myopathy
- Requirement of B7-H1 in mesenchymal stem cells for immune tolerance to cardiac allografts in combination therapy with Rapamycin
- Mammalian target of Rapamycin (mTOR) inhibitor‐associated non‐infectious pneumonitis in patients with renal cell cancer: predictors, management, and …
- Systematic combination screening reveals synergism between Rapamycin and sunitinib against human lung cancer
- Rapamycin has suppressive and stimulatory effects on human plasmacytoid dendritic cell functions
- Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical Rapamycin
- West nile virus-induced activation of mammalian target of Rapamycin complex 1 supports viral growth and viral protein expression
- Rapamycin Augments Human DC IL‐12p70 and IL‐27 Secretion to Promote Allogeneic Type1 Polarization Modulated by NK Cells
- Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency
- Resveratrol potentiates Rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet
- The Mammalian target of Rapamycin inhibitors in breast cancer: current evidence and future directions
- Disruption of an hTERT–mTOR–RAPTOR protein complex by a phytochemical perillyl alcohol and Rapamycin
- Clinical impacts of mammalian target of Rapamycin expression in human colorectal cancers
- The mTOR inhibitor Rapamycin synergizes with a fatty acid synthase inhibitor to induce cytotoxicity in ER/HER2-positive breast cancer cells
- Treatment of angiofibromas in tuberous sclerosis complex: the effect of topical Rapamycin and concomitant laser therapy
- Mammalian target of Rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle
- Rapamycin in preventive (very low) doses
- Dual inhibitor of phosphoinositide 3-kinase/mammalian target of Rapamycin NVP-BEZ235 effectively inhibits cisplatin-resistant urothelial cancer cell growth through …
- Administration of low doses of IL‐2 combined to Rapamycin promotes allogeneic skin graft survival in mice
- Incidence and risk of treatment-related mortality in cancer patients treated with the mammalian target of Rapamycin inhibitors
- Rapamycin slows IgA nephropathy progression in the rat
- Rapamycin inhibits transforming growth factor β1-induced fibrogenesis in primary human lung fibroblasts
- Murine dendritic cell Rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction
- Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for Rapamycin
- … (Astyanax fasciatus mexicanus): effects on feeding and on the brain expression levels of tyrosine hydroxylase, mechanistic target of Rapamycin and appetite-related …
- Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to Rapamycin induced apoptosis by down‐regulation of Mcl‐1 in mantle cell lymphoma
- The effects of Rapamycin on regulatory T cells: its potential time-dependent role in inducing transplant tolerance
- Combination of Rapamycin, CI-1040, and 17-AAG inhibits metastatic capacity of prostate cancer via Slug inhibition
- Mammalian target of Rapamycin inhibitors induce tumor cell apoptosis in vivo primarily by inhibiting VEGF expression and angiogenesis
- Rapamycin reduces burn wound progression by enhancing autophagy in deep second‐degree burn in rats
- … matrix-modulated Heartless signaling in Drosophila blood progenitors regulates their differentiation via a Ras/ETS/FOG pathway and target of Rapamycin …
- Rapamycin induces autophagy in the melanoma cell line M14 via regulation of the expression levels of Bcl‑2 and Bax
- A phase I study of decitabine and Rapamycin in relapsed/refractory AML
- … amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila
- … -type CD8+ T cells correlates with the failure of early immunosuppression withdrawal after cadaver liver transplantation using high-dose ATG induction and Rapamycin
- Palmitate induces mRNA translation and increases ER protein load in islet β-cells via activation of the mammalian target of Rapamycin pathway
- Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model
- Increasing leucine concentration stimulates mechanistic target of Rapamycin signaling and cell growth in C2C12 skeletal muscle cells
- Characterization and pharmacokinetic analysis of crystalline versus amorphous Rapamycin dry powder via pulmonary administration in rats
- Olanzapine activates hepatic mammalian target of Rapamycin: new mechanistic insight into metabolic dysregulation with atypical antipsychotic drugs
- Environmental signaling through the mechanistic target of Rapamycin complex 1: mTORC1 goes nuclear
- Mammalian target of Rapamycin signaling activation patterns in pancreatic neuroendocrine tumors
- A novel Rapamycin-polymer conjugate based on a new poly (ethylene glycol) multiblock copolymer
- Mechanical activation of mammalian target of Rapamycin pathway is required for cartilage development
- Rapamycin inhibits oxidative and angiogenic mediators in diabetic retinopathy
- The mTOR inhibitor Rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling
- Target of Rapamycin (TOR) kinase in Trypanosoma brucei: an extended family
- Crystalline coating of Rapamycin onto a stent: Process development and characterization
- Equivalent benefit of Rapamycin and a potent mTOR ATP-competitive inhibitor, MLN0128 (INK128), in a mouse model of tuberous sclerosis
- Berberine sensitizes Rapamycin‑mediated human hepatoma cell death in vitro
- Regulation of blood–testis barrier (BTB) dynamics during spermatogenesis via the “Yin” and “Yang” effects of mammalian target of Rapamycin complex 1 (mTORC1) …
- Topical Rapamycin systematically suppresses the early stages of pulsed dye laser‐induced angiogenesis pathways
- Studies on process optimization methods for Rapamycin production using Streptomyces hygroscopicus ATCC 29253
- Mammalian target of Rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC …
- Branched-chain amino acids enhance premature senescence through mammalian target of Rapamycin complex I-mediated upregulation of p21 protein
- Effects of the immunosuppressant Rapamycin on the expression of human α2 (I) collagen and matrix metalloproteinase 1 genes in scleroderma dermal fibroblasts
- Cumulative number of altered biomarkers in mammalian target of Rapamycin pathway is an independent predictor of outcome in patients with clear cell renal cell …
- Mammalian target of Rapamycin complex 1 activation negatively regulates Polo-like kinase 2-mediated homeostatic compensation following neonatal seizures
- Chemical genetics of Rapamycin-insensitive TORC2 in S. cerevisiae
- Rapamycin promoted thrombosis and platelet adhesion to endothelial cells by inducing membrane remodeling
- Relative resistance to mammalian target of Rapamycin inhibition in vascular smooth muscle cells of diabetic donors
- AMP‐activated protein kinase counteracts brain‐derived neurotrophic factor‐induced mammalian target of Rapamycin complex 1 signaling in neurons
- YM155 reverses Rapamycin resistance in renal cancer by decreasing survivin
- β-hydroxy-β-methylbutyrate facilitates pi3k/akt-dependent mammalian target of Rapamycin and foxo1/3a phosphorylations and alleviates tumor necrosis factor α …
- Mechanistic target of Rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor
- CD44-tropic polymeric nanocarrier for breast cancer targeted Rapamycin chemotherapy
- Mechanistic target of Rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins
- Bidirectional regulation of nuclear factor-κB and mammalian target of Rapamycin signaling functionally links Bnip3 gene repression and cell survival of ventricular …
- Kinetics of Rapamycin production by Streptomyces hygroscopicus MTCC 4003
- Growth differentiation factor 15 stimulates Rapamycin-sensitive ovarian cancer cell growth and invasion
- Carrier free Rapamycin loaded drug eluting stent: in vitro and in vivo evaluation
- Exome sequencing reveals de novo germline mutation of the mammalian target of Rapamycin (mTOR) in a patient with megalencephaly and intractable seizures
- Pharmacophore modeling, homology modeling, and in silico screening reveal mammalian target of Rapamycin inhibitory activities for sotalol, glyburide, metipranolol …
- Uth1 is a mitochondrial inner membrane protein dispensable for post‐log‐phase and Rapamycin‐induced mitophagy
- Requirement of Mammalian target of Rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence
- Rapamycin enhances HBV production by inducing cellular autophagy
- Rapamycin-induced modulation of HIV gene transcription attenuates progression of HIVAN
- Improvement of the antiproliferative effect of Rapamycin on tumor cell lines by poly (monomethylitaconate)-based pH-sensitive, plasma stable liposomes
- Mammalian target of Rapamycin inhibitors resistance mechanisms in clear cell renal cell carcinoma
- A novel semisynthetic inhibitor of the FRB domain of mammalian target of Rapamycin blocks proliferation and triggers apoptosis in chemoresistant prostate cancer cells
- Mammalian target of Rapamycin is essential for cardiomyocyte survival and heart development in mice
- Dysregulation of mammalian target of Rapamycin pathway in upper tract urothelial carcinoma
- … of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of Rapamycin activity in the …
- A Rapamycin-releasing perivascular polymeric sheath produces highly effective inhibition of intimal hyperplasia
- MNK kinases facilitate c-myc IRES activity in Rapamycin-treated multiple myeloma cells
- Hyperactivation of mammalian target of Rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced …
- Rapamycin induces pluripotent genes associated with avoidance of replicative senescence
- Electrospun Rapamycin-eluting polyurethane fibers for vascular grafts
- Rapamycin attenuated cardiac hypertrophy induced by isoproterenol and maintained energy homeostasis via inhibiting NF-κB activation
- Blockade of epidermal growth factor receptor/mammalian target of Rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells
- Rheb (Ras homologue enriched in brain)-dependent mammalian target of Rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac …
- Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of Rapamycin pathway
- Rapamycin inhibits acrolein‐induced apoptosis by alleviating ROS‐driven mitochondrial dysfunction in male germ cells
- Low concentration of Rapamycin inhibits hemangioma endothelial cell proliferation, migration, and vascular tumor formation in mice
- Mammalian target of Rapamycin complex 1 (m TORC 1) may modulate the timing of anagen entry in mouse hair follicles
- Chronic Rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo
- Rheb activation in subventricular zone progenitors leads to heterotopia, ectopic neuronal differentiation, and Rapamycin-sensitive olfactory micronodules and dendrite …
- MicroRNA-21 mediates the Rapamycin-induced suppression of endothelial proliferation and migration
- Rapamycin modulates markers of mitochondrial biogenesis and fatty acid oxidation in the adipose tissue of db/db mice
- Role of GAS5 noncoding RNA in mediating the effects of Rapamycin and its analogues on mantle cell lymphoma cells
- Inhibitory effect of paclitaxel and Rapamycin individual and dual drug-loaded polymeric micelles in the angiogenic cascade
- Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer
- Eukaryotic Initiation Factor 2α-a Downstream Effector of Mammalian Target of Rapamycin-Modulates DNA Repair and Cancer Response to Treatment
- Production of Rapamycin in Streptomyces hygroscopicus from glycerol-based media optimized by systemic methodology
- Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice
- Neuronal-specific iron deficiency dysregulates mammalian target of Rapamycin signaling during hippocampal development in nonanemic genetic mouse models
- Targeted inhibition of mammalian target of Rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells
- The role of mammalian target of Rapamycin (mTOR) inhibition in the treatment of advanced breast cancer
- Anorexigenic and orexigenic hormone modulation of mammalian target of Rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein …
- Rapamycin inhibits BMP‐7‐induced osteogenic and lipogenic marker expressions in fetal rat calvarial cells
- Over-expression of phosphorylated mammalian target of Rapamycin is associated with poor survival in oesophageal adenocarcinoma: a tissue microarray study
- Rapamycin prolongs female reproductive lifespan
- Mechanistic target of Rapamycin (mTOR) signaling genes in decapod crustaceans: cloning and tissue expression of mTOR, Akt, Rheb, and p70 S6 kinase in the green …
- Relevance of the mammalian target of Rapamycin pathway in the prognosis of patients with high-risk non–muscle invasive bladder cancer
- Spatiotemporal control of vascular endothelial growth factor expression using a heat-shock-activated, Rapamycin-dependent gene switch
- Rapamycin‐sensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary
- TORC 1 signaling inhibition by Rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast
- Risk of infections in renal cell carcinoma (RCC) and non-RCC patients treated with mammalian target of Rapamycin inhibitors
- microRNA regulation of mammalian target of Rapamycin expression and activity controls estrogen receptor function and RAD001 sensitivity
- gln3 mutations dissociate responses to nitrogen limitation (nitrogen catabolite repression) and Rapamycin inhibition of TorC1
- Next generation of mammalian target of Rapamycin inhibitors for the treatment of cancer
- Mammalian target of Rapamycin in inflammatory skin conditions
- Alterations in the Ure2 αCap domain elicit different GATA factor responses to Rapamycin treatment and nitrogen limitation
- PI3Kδ inhibition augments the efficacy of Rapamycin in suppressing proliferation of Epstein− Barr virus (EBV)+ B cell lymphomas
- Accumulation of dephosphorylated 4EBP after mTOR inhibition with Rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene
- inhibition of Rapamycin-induced AKT activation elicits differential antitumor response in head and neck cancers
- Rapamycin regulates connective tissue growth factor expression of lung epithelial cells via phosphoinositide 3-kinase
- Mis-regulation of mammalian target of Rapamycin (mTOR) complexes induced by albuminuria in proximal tubules
- Morphoproteomic profiling of the mammalian target of Rapamycin (mTOR) signaling pathway in desmoplastic small round cell tumor (EWS/WT1), Ewing’s …
- The search continues: looking for predictive biomarkers for response to mammalian target of Rapamycin inhibition in endometrial cancer
- Rapamycin protects against Aβ-induced synaptotoxicity by increasing presynaptic activity in hippocampal neurons
- Expression of budding yeast FKBP12 confers Rapamycin susceptibility to the unicellular red alga Cyanidioschyzon merolae
- Rapamycin-Induced apoptosis in HGF-stimulated lens epithelial cells by AKT/mTOR, ERK and JAK2/STAT3 pathways
- Breast cancer tissue slices as a model for evaluation of response to Rapamycin
- Metformin and Rapamycin are master-keys for understanding the relationship between cell senescent, aging and cancer
- GSK3β, but not GSK3α, inhibits the neuronal differentiation of neural progenitor cells as a downstream target of mammalian target of Rapamycin complex1
- Rapamycin‐loaded poly (ε‐caprolactone)‐poly (ethylene glycol)‐poly (ε‐caprolactone) nanoparticles: preparation, characterization and potential application in …
- Branched chain amino acid suppresses hepatocellular cancer stem cells through the activation of mammalian target of Rapamycin
- Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of Rapamycin (mTOR)
- Role of mammalian target of Rapamycin inhibitor in the treatment of metastatic epithelioid angiomyolipoma: A case report
- Dual phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 has a therapeutic potential and sensitizes cisplatin in nasopharyngeal …
- inhibition of mammalian target of Rapamycin signaling pathway decreases retinoic acid stimulated gene 8 expression in adult mouse testis
- Role of the mammalian target of Rapamycin (mTOR) complexes in pancreatic β-cell mass regulation
- Rapamycin promotes Schwann cell migration and nerve growth factor secretion
- Arsenic trioxide overcomes Rapamycin-induced feedback activation of AKT and ERK signaling to enhance the anti-tumor effects in breast cancer
- Metformin impairs vascular endothelial recovery after stent placement in the setting of locally eluted mammalian target of Rapamycin inhibitors via S6 kinase …
- Phase I/IIa trial of the mammalian target of Rapamycin inhibitor ridaforolimus (AP23573; MK-8669) administered orally in patients with refractory or advanced …
- Phosphoinositide-3 kinase/protein kinase-B/mammalian target of Rapamycin pathway in psoriasis pathogenesis. A potential therapeutic target?
- SOX 2 promotes tumor growth of esophageal squamous cell carcinoma through the AKT/mammalian target of Rapamycin complex 1 signaling pathway
- … proliferation by negatively regulating phosphodiesterase-4, extracellular signal-regulated kinase, Akt/mammalian target of Rapamycin kinase, and nuclear factor …
- Endocrine resistance in breast cancer: focus on the phosphatidylinositol 3-kinase/akt/mammalian target of Rapamycin signaling pathway
- Autoimmune pancreatitis in MRL/Mp mice is a T cell-mediated disease responsive to cyclosporine A and Rapamycin treatment
- Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle
- Comparative effects of PP242 and Rapamycin on mTOR signalling and NOTCH signalling in leukemia cells
- Rapamycin attenuates endothelial apoptosis induced by low shear stress via mTOR and sestrin1 related redox regulation
- Mammalian target of Rapamycin inhibitor Rapamycin enhances anti‐leukemia effect of imatinib on P h+ acute lymphoblastic leukemia cells
- … synthesis in response to exogenous growth hormone is associated with changes in mechanistic (mammalian) target of Rapamycin (mTOR) C1-dependent and …
- Mammalian target of Rapamycin complex 1 and cyclooxygenase 2 pathways cooperatively exacerbate endometrial cancer
- A phase I trial of sunitinib and Rapamycin in patients with advanced non-small cell lung cancer
- Autoregulation of the mechanistic target of Rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism
- Dysregulation of the mammalian target of Rapamycin and p27Kip1 promotes intimal hyperplasia in diabetes mellitus
- Ferulic acid induces mammalian target of Rapamycin inactivation in cultured mammalian cells
- Rapamycin ameliorates neuropathic pain by activating autophagy and inhibiting interleukin-1β in the rat spinal cord
- Staurosporine induces dopaminergic neurite outgrowth through AMP-activated protein kinase/mammalian target of Rapamycin signaling pathway
- Osteolysis and pain due to experimental bone metastases are improved by treatment with Rapamycin
- Effect of Rapamycin and interleukin-2 on regulatory CD4+ CD25+ Foxp3+ T cells in mice after allogenic corneal transplantation
- The mechanistic target for Rapamycin pathway is related to the phosphorylation score for estrogen receptor-α in human breast tumors in vivo
- Trilayer micelles for combination delivery of Rapamycin and siRNA targeting Y-box binding protein-1 (siYB-1)
- Over‐expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by Rapamycin and is sufficient to ameliorate Alzheimer’s‐like deficits in mice …
- Role of energy‐and nutrient‐sensing kinases AMP‐activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in Adipocyte Differentiation
- Rapamycin ameliorates nephropathy despite elevating hyperglycemia in a polygenic mouse model of type 2 diabetes, NONcNZO10/LtJ
- Rapamycin together with TGF-β1, IL-2 and IL-15 induces the generation of functional regulatory γδT cells from human peripheral blood mononuclear cells
- Analysis of Rapamycin induced autophagy in Dictyostelium discoideum
- Role of inhibitors of mammalian target of Rapamycin in the treatment of luminal breast cancer
- Ptc6 is required for proper Rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae
- Evaluation of the prognostic significance of altered mammalian target of Rapamycin pathway biomarkers in upper tract urothelial carcinoma
- Rapamycin induces apoptosis when autophagy is inhibited in T-47D mammary cells and both processes are regulated by Phlda1
- p38α senses environmental stress to control innate immune responses via mechanistic target of Rapamycin
- Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M
- Rapamycin regulates iTreg function through CD39 and Runx1 pathways
- Rapamycin inhibits both motility through down-regulation of p-STAT3 (S727) by disrupting the mTORC2 assembly and peritoneal dissemination in sarcomatoid …
- Mammalian target of Rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development
- Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of Rapamycin complex 1 (mTORC1) in mice and zebrafish
- Metabolomic evaluation of Mitomycin C and Rapamycin in a personalized treatment of pancreatic cancer
- Rapamycin treatment of healthy pigs subjected to acute myocardial ischemia-reperfusion injury attenuates cardiac functions and increases myocardial necrosis
- Comparison of posterior capsule opacification in rabbit eyes receiving different administrations of Rapamycin
- Mammalian tribbles homologs at the crossroads of endoplasmic reticulum stress and mammalian target of Rapamycin pathways
- Inhibitory effects of Rapamycin on the different stages of hepatic fibrosis
- Regulation of mammalian target of Rapamycin complex 1 by Bcl-2 and Bcl-XL proteins
- Transforming growth factor β integrates Smad 3 to mechanistic target of Rapamycin complexes to arrest deptor abundance for glomerular mesangial cell …
- Genetic interactions between protein phosphatases CaPtc2p and CaPph3p in response to genotoxins and Rapamycin in Candida albicans
- Syntaxin13 expression is regulated by mammalian target of Rapamycin (mTOR) in injured neurons to promote axon regeneration
- Combination of cetuximab and Rapamycin enhances the therapeutic efficacy in hepatocellular carcinoma
- Oedema, solid organ transplantation and mammalian target of Rapamycin inhibitor/proliferation signal inhibitors (mTOR-I/PSIs)
- Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of Rapamycin
- Rapamycin is less fibrogenic than Cyclosporin A as demonstrated in a rat model of chronic allograft nephropathy
- Pharmacodynamic and antineoplastic activity of BI 836845, a fully human IGF ligand-neutralizing antibody, and mechanistic rationale for combination with Rapamycin
- Effects of dissolved oxygen level on Rapamycin production by pellet-form of Streptomyces hygroscopicus
- Mammalian target of Rapamycin inhibitors permit regulatory T cell reconstitution and inhibit experimental chronic graft-versus-host disease
- … factor‐1α/vascular endothelial growth factor expression via inhibiting phosphatidylinositol 3‐kinase/Akt/mammalian target protein of Rapamycin pathway in multiple …
- … increase the phosphorylation of tuberous sclerosis complex‐2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of Rapamycin to the lysosome
- … transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of Rapamycin (mTOR)/ribosomal S6 …
- Rapamycin attenuates bladder hypertrophy during long-term outlet obstruction in vivo: tissue, matrix and mechanistic insights
- Rapamycin delays salivary gland atrophy following ductal ligation
- Mechanistic target of Rapamycin in common carp: cDNA cloning, characterization, and tissue expression
- Rapamycin inhibits pre-B acute lymphoblastic leukemia cells by downregulating DNA and RNA polymerases
- … -associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of Rapamycin complex 1 (mTORC1)
- Rapamycin regulates biochemical metabolites
- Mammalian target of Rapamycin (mTOR) activity dependent phospho-protein expression in childhood acute lymphoblastic leukemia (ALL)
- The roles of juvenile hormone, insulin/target of Rapamycin, and ecydsone signaling in regulating body size in Drosophila
- … 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of Rapamycin in complex 1 (mTORC1)
- Rapamycin blocks fibrocyte migration and attenuates bronchiolitis obliterans in a murine model
- Myxoid liposarcoma and the mammalian target of Rapamycin pathway
- … protein 2A promotes the epithelial-mesenchymal transition in nasopharyngeal carcinoma via metastatic tumor antigen 1 and mechanistic target of Rapamycin …
- Rapamycin reduces renal hypoxia, interstitial inflammation and fibrosis in a rat model of unilateral ureteral obstruction
- Rapamycin-induced modulation of miRNA expression is associated with amelioration of HIV-associated nephropathy (HIVAN)
- Interferon alpha and Rapamycin inhibit the growth of pheochromocytoma PC12 line in vitro
- Mammalian target of Rapamycin complex 1 activation in podocytes promotes cellular crescent formation
- Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D
- … triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of Rapamycin and glycogen synthase …
- Role of phosphatidylinositol-3-kinase (PI3K) and the mammalian target of Rapamycin (mTOR) signalling pathways in porcine reproductive and respiratory syndrome …
- Beclin 1 is required for starvation-enhanced, but not Rapamycin-enhanced, LC3-associated phagocytosis of Burkholderia pseudomallei in RAW 264.7 cells
- Gingipain‐dependent degradation of mammalian target of Rapamycin pathway proteins by the periodontal pathogen Porphyromonas gingivalis during invasion
- It may be possible to delay the onset of neurodegenerative diseases with an immunosuppressive drug (Rapamycin)
- Suppression of AKT phosphorylation restores Rapamycin-based synthetic lethality in SMAD4-defective pancreatic cancer cells
- Rapamycin protects kidney against ischemia reperfusion injury through recruitment of NKT cells
- Effects of combined administration of Rapamycin, tolvaptan, and AEZ-131 on the progression of polycystic disease in PCK rats
- Divergent tissue and sex effects of Rapamycin on the proteasome-chaperone network of old mice
- Immunohistochemical expression of the mammalian target of Rapamycin pathway in penile squamous cell carcinomas: a tissue microarray study of 112 cases
- Metabolic effects of acute thiamine depletion are reversed by Rapamycin in breast and leukemia cells
- Mechanistic target of Rapamycin (mTOR) signaling during ovulation in mice
- Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with Rapamycin and metformin
- Resveratrol inhibits the phosphatidylinositide 3‑kinase/protein kinase B/mammalian target of Rapamycin signaling pathway in the human chronic myeloid …
- mTOR activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of Rapamycin in vitro and in vivo
- inhibition of mTOR kinase via Rapamycin blocks persistent predator stress-induced hyperarousal
- All‐trans retinoic acid and Rapamycin synergize with transforming growth factor‐β1 to induce regulatory T cells but confer different migratory capacities
- Activation of mammalian target of Rapamycin contributes to pain nociception induced in rats by BmK I, a sodium channel-specific modulator
- Long-term treatment with mammalian target of Rapamycin inhibitor does not benefit patients with autosomal dominant polycystic kidney disease: a meta-analysis
- Mammalian target of Rapamycin pathway is up-regulated by both acute endurance exercise and chronic muscle contraction in rat skeletal muscle
- Differential regulation of carbon partitioning by the central growth regulator target of Rapamycin (TOR)
- Granulocyte macrophage colony‐stimulating factor promotes regeneration of retinal ganglion cells in vitro through a mammalian target of Rapamycin‐dependent …
- Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of Rapamycin complex 2)
- Effects of breed and dietary nutrient density on the growth performance, blood metabolite, and genes expression of target of Rapamycin (TOR) signalling pathway of …
- Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapy
- Rapamycin interacts synergistically with idarubicin to induce T-leukemia cell apoptosis in vitro and in a mesenchymal stem cell simulated drug-resistant …
- Labor inhibits placental mechanistic target of Rapamycin complex 1 signaling
- Increased mammalian target of Rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function
- Rapamycin sensitizes glucocorticoid resistant acute lymphoblastic leukemia CEM-C1 cells to dexamethasone induced apoptosis through both mTOR suppression and …
- Low-dose Rapamycin unmasks the protective potential of targeting intragraft NF-κB for islet transplants
- Familial multiple discoid fibromas: unique histological features and therapeutic response to topical Rapamycin
- Expression of molecular markers associated with the mammalian target of Rapamycin pathway in nonmetastatic renal cell carcinoma: Effect on prognostic outcomes …
- Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of Rapamycin (mTOR)
- Adventitial nab-Rapamycin injection reduces porcine femoral artery luminal stenosis induced by balloon angioplasty via inhibition of medial proliferation and adventitial …
- … pathogenic T cells and interferes with their trafficking to the central nervous system, implicating sphingosine-1 phosphate receptor 1–mammalian target of Rapamycin …
- A reversed phase high performance liquid chromatographic method for determination of Rapamycin
- Effects of limiting energy availability via diet and physical activity on mammalian target of Rapamycin-related signaling in rat mammary carcinomas
- Pentoxifylline and propentofylline prevent proliferation and activation of the mammalian target of Rapamycin and mitogen activated protein kinase in cultured spinal …
- Activation of mammalian target of Rapamycin complex 1 (mTORC1) and Raf/Pyk2 by growth factor‐mediated Eph receptor 2 (EphA2) is required for …
- Rapamycin‐resistant effector T‐cell therapy
- Activation of the Akt/mammalian target of Rapamycin pathway in myxofibrosarcomas
- Confirmation of the cellular targets of benomyl and Rapamycin using next-generation sequencing of resistant mutants in S. cerevisiae
- Effects of advanced age on whole-body protein synthesis and skeletal muscle mechanistic target of Rapamycin signaling in horses
- Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2, and PTK6 as sensitizing targets of Rapamycin activity
- Effect of inhibiting the signal of mammalian target of Rapamycin on memory T cells
- Mammalian target of Rapamycin coordinates iron metabolism with iron-sulfur cluster assembly enzyme and tristetraprolin
- Antiangiogenic therapy using sunitinib combined with Rapamycin retards tumor growth but promotes metastasis
- Rapamycin inhibition of mTORC1 reverses lithium-induced proliferation of renal collecting duct cells
- Rapamycin attenuates visible light-induced injury in retinal photoreceptor cells via inhibiting endoplasmic reticulum stress
- Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis
- Mechanistic/mammalian target protein of Rapamycin signaling in hematopoietic stem cells and leukemia
- Coupled cell morphology investigation and metabolomics analysis improves Rapamycin production in Streptomyces hygroscopicus
- … nitric oxide synthase participates in pemphigus vulgaris acantholysis through upregulation of Rous sarcoma, mammalian target of Rapamycin and focal adhesion …
- Diversified targets of FKBP25 and its complex with Rapamycin
- Rapamycin increases pCREB, Bcl-2, and VEGF-A through ERK under normoxia
- Topical application of Rapamycin ointment ameliorates Dermatophagoides farina body extract‐induced atopic dermatitis in NC/Nga mice
- T cells and lung injury. Impact of Rapamycin
- Autophagic inhibitor attenuates Rapamycin-induced inhibition of proliferation in cultured A549 lung cancer cells
- inhibition of mammalian target of Rapamycin by Rapamycin increases the radiosensitivity of esophageal carcinoma Eca109 cells
- Biodegradable Rapamycin-eluting nano-fiber membrane-covered metal stent placement to reduce fibroblast proliferation in experimental stricture in a canine model
- Activation of mammalian target of Rapamycin mediates rat pain-related responses induced by BmK I, a sodium channel-specific modulator
- Immune memory–boosting dose of Rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute …
- Conversion from calcineurin inhibitor–based immunosuppression to mammalian target of Rapamycin inhibitors or belatacept in renal transplant recipients
- Rapamycin resistant murine th9 cells have a stable in vivo phenotype and inhibit graft-versus-host reactivity
- Rapamycin inhibits Toll-like receptor 4-induced pro-oncogenic function in head and neck squamous cell carcinoma
- Novel targeting of Phoshatidylinositol-3 Kinase and Mammalian Target of Rapamycin (mTOR) in renal cell carcinoma
- Draft genome sequence of Streptomyces Rapamycinicus strain NRRL 5491, the producer of the immunosuppressant Rapamycin
- Should mammalian target of Rapamycin inhibitors be stopped in women with lymphangioleiomyomatosis awaiting lung transplantation?
- ScFKBP12 bridges Rapamycin and AtTOR in Arabidopsis
- … of microRNA-99a promotes cell invasion and down-regulates E-cadherin expression in pancreatic cancer cells by regulating mammalian target of Rapamycin
- The effect of bortezomib and Rapamycin on telomerase activity in mantle cell lymphoma
- Effects of Chronic Akt/mTOR inhibition by Rapamycin on Mechanical Overload–Induced Hypertrophy and Myosin Heavy Chain Transition in Masseter Muscle
- New strategies to overcome resistance to mammalian target of Rapamycin inhibitors in breast cancer
- MEDI-573, alone or in combination with mammalian target of Rapamycin inhibitors, targets the insulin-like growth factor pathway in sarcomas
- Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system
- Immunohistochemical analysis of the mechanistic target of Rapamycin and hypoxia signalling pathways in basal cell carcinoma and trichoepithelioma
- Chronic mechanistic target of Rapamycin inhibition: preventing cancer to delay aging, or vice versa?
- Tribbles homolog 3 attenuates mammalian target of Rapamycin complex-2 signaling and inflammation in the diabetic kidney
- IL-12hi Rapamycin-Conditioned Dendritic Cells Mediate IFN-γ–Dependent Apoptosis of Alloreactive CD4+ T Cells In Vitro and Reduce Lethal Graft-Versus …
- Phase 2 clinical trial of Rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation
- … of cost-effectiveness of oral Rapamycin plus bare-metal stents versus first generation of drug-eluting stents (from the Randomized Oral Rapamycin in Argentina [ORAR …
- Dysregulation of mammalian target of Rapamycin pathway in plasmacytoid variant of urothelial carcinoma of the urinary bladder
- … protein 1 in radical nephrectomy specimens as a prognostic predictor in patients with metastatic renal cell carcinoma treated with mammalian target of Rapamycin …
- Rapid regulation of nuclear proteins by Rapamycin‐induced translocation in fission yeast
- Induction of cytokines and growth factors by Rapamycin in the microenvironment of brain metastases of lung cancer
- Association of mammalian target of Rapamycin with aggressive type II endometrial carcinomas and poor outcome: a potential target treatment
- Short-term Rapamycin treatment in mice has few effects on the transcriptome of white adipose tissue compared to dietary restriction
- Mechanistic target of Rapamycin (mTOR) dependent regulation of thioredoxin interacting protein (TXNIP) transcription in hypoxia
- The mammalian target of Rapamycin pathway in the basolateral amygdala is critical for nicotine-induced behavioural sensitization
- Metastatic perivascular epithelioid cell tumor responding to mammalian target of Rapamycin inhibition
- A new functional role for mechanistic/mammalian target of Rapamycin complex 1 (mTORC1) in the circadian regulation of L-type voltage-gated calcium …
- Targeting gallbladder cancer: oncolytic virotherapy with myxoma virus is enhanced by Rapamycin in vitro and further improved by hyaluronan in vivo
- The Akt-mTOR pathway in Down’s syndrome: the potential use of Rapamycin/rapalogs for treating cognitive deficits
- Effects of level of nutrient intake and age on mammalian target of Rapamycin, insulin, and insulin-like growth factor-1 gene network expression in skeletal …
- Mammalian target of Rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts
- Precursor engineering and cell physiological regulation for high level Rapamycin production by Streptomyces hygroscopicus
- Rictor/mammalian target of Rapamycin 2 regulates the development of Notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3
- Clinicopathologic significance and function of mammalian target of Rapamycin activation in esophageal squamous cell carcinoma
- Rapamycin and mTOR inhibitors probably have therapeutic effects for post-operative cognitive dysfunction
- The impact of everolimus versus other Rapamycin derivative-eluting stents on clinical outcomes in patients with coronary artery disease: A meta-analysis of 16 …
- A domain in the transcription activator Gln3 specifically required for Rapamycin responsiveness
- Combination of rituximab and mammalian target of Rapamycin inhibitor everolimus (RAD001) in diffuse large B-cell lymphoma
- Dysregulation of the mammalian target of Rapamycin pathway in chromophobe renal cell carcinomas
- Rapamycin ameliorates proteinuria and restores nephrin and podocin expression in experimental membranous nephropathy
- … CYP2E1: miR-132/-212 targeting of CYP2E1 and role of phosphatidylinositol 3-kinase, Akt (protein kinase B), mammalian target of Rapamycin signaling in regulating …
- The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for Rapamycin-induced feedback activation of PI3K and AKT
- MicroRNA-21 is induced by Rapamycin in a model of tuberous sclerosis (TSC) and lymphangioleiomyomatosis (LAM)
- Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of Rapamycin (mTOR)
- Adenosine triphosphate promotes locomotor recovery after spinal cord injury by activating mammalian target of Rapamycin pathway in rats
- Multi-scale optical imaging of the delayed type hypersensitivity reaction attenuated by Rapamycin
- The combination of Rapamycin and MAPK inhibitors enhances the growth inhibitory effect on Nara-H cells
- Rapamycin prevents N‐methyl‐D‐aspartate‐induced retinal damage through an ERK‐dependent mechanism in rats
- Iron metabolism, hepcidin, and anemia in orthotopic heart transplantation recipients treated with mammalian target of Rapamycin
- Adenosine Monophosphate–activated Protein Kinase/Mammalian Target of Rapamycin–dependent Autophagy Protects Human Dental Pulp Cells against Hypoxia
- The novel phosphoinositide 3‐kinase–mammalian target of Rapamycin inhibitor, BEZ235, circumvents erlotinib resistance of epidermal growth factor receptor mutant …
- Biological constraints limit the use of Rapamycin-inducible FKBP12-Inp54p for depleting PIP 2 in dorsal root ganglia neurons
- Mammalian target of Rapamycin complex 1 (mTORC1) plays a role in Pasteurella multocida toxin (PMT)-induced protein synthesis and proliferation in Swiss …
- Target of Rapamycin signaling regulates high mobility group protein association to chromatin, which functions to suppress necrotic cell death
- Rapamycin-binding FKBP25 associates with diverse proteins that form large intracellular entities
- Characterization of the immersion properties of the peripheral membrane anchor of the FATC domain of the kinase “target of Rapamycin” by NMR, oriented CD …
- Stathmin Regulates Hypoxia-Inducible Factor-1 Expression through the Mammalian Target of Rapamycin Pathway in Ovarian Clear Cell Adenocarcinoma
- Chemotherapy of skull base chordoma tailored on responsiveness of patient-derived tumor cells to Rapamycin
- CD4+CD25−Nrp1+ T Cells Synergize with Rapamycin to Prevent Murine Cardiac Allorejection in Immunocompetent Recipients
- Enteral delivery of proteins stimulates protein synthesis in human duodenal mucosa in the fed state through a mammalian target of Rapamycin–independent pathway
- Tuberous sclerosis associated with polycystic kidney disease: effects of Rapamycin after renal transplantation
- Rapamycin-enhanced mitomycin C-induced apoptotic death is mediated through the S6K1–Bad–Bak pathway in peritoneal carcinomatosis
- Rapamycin combined with celecoxib enhanced antitumor effects of mono treatment on chronic myelogenous leukemia cells through downregulating mTOR pathway
- Earle’s balanced salts solution and Rapamycin differentially regulate the Bacillus Calmette-Guerin-induced maturation of human dendritic cells
- First-line Mammalian target of Rapamycin inhibition in metastatic renal cell carcinoma: an analysis of practice patterns from the International Metastatic Renal Cell …
- Addition of Rapamycin to anti-CD3 antibody improves long-term glycaemia control in diabetic NOD mice
- Limitations of IL-2 and Rapamycin in immunotherapy of type 1 diabetes
- Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by Rapamycin
- Pretreatment of Rapamycin before allogenic corneal transplant promotes graft survival through increasing CD4 (+) CD25 (+) Foxp3 (+) regulatory T cells
- NVP-BEZ235, dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor, prominently enhances radiosensitivity of prostate cancer cell line PC-3
- Rapamycin reduces Drosophila longevity under low nutrition
- Insulin infusion stimulates whole-body protein synthesis and activates the upstream and downstream effectors of mechanistic target of Rapamycin signaling in the …
- Bioprocess engineering aspects of Rapamycin (sirolimus) production: a review on past achievements and recent perspectives
- Alterations of hypoxia-induced factor signaling pathway due to mammalian target of Rapamycin (mTOR) suppression in ovarian clear cell adenocarcinoma: in vivo and …
- Rapamycin enhances TNF-α-induced secretion of IL-6 and IL-8 through suppressing PDCD4 degradation in orbital fibroblasts
- Visible effects of Rapamycin (sirolimus) on human skin explants in vitro
- Mammalian target of Rapamycin pathway activity in alveolar soft part sarcoma
- Long-term effects of conversion from cyclosporine to Rapamycin on testicular function and morphology in a rat transplantation model
- The enhancement of Rapamycin production using Streptomyces hygroscopicus through a simple pH-shifted control
- Rrd1p, an RNA polymerase II-specific prolyl isomerase and activator of phosphoprotein phosphatase, promotes transcription independently of Rapamycin response
- … significance and therapeutic potential of the activation of anaplastic lymphoma kinase/protein kinase B/mammalian target of Rapamycin signaling pathway in …
- Activation of mammalian target of Rapamycin (mTOR) in triple negative feline mammary carcinomas
- Placental, lipid, and glucidic effects of mammalian target of Rapamycin inhibitors: impact on fetal growth and metabolic disorders during pregnancy after solid organ …
- The antiviral immune response in human conventional dendritic cells is controlled by the mammalian target of Rapamycin
- inhibition of Rapamycin-induced Akt phosphorylation by cotylenin A correlates with their synergistic growth inhibition of cancer cells
- Rapamycin enhances cetuximab cytotoxicity by inhibiting mTOR-mediated drug resistance in mesenchymal hepatoma cells
- Mammalian target of Rapamycin (mTOR) inhibitors and combined chemotherapy in breast cancer: a meta-analysis of randomized controlled trials
- Synthesis of Rapamycin glycoconjugates via a CuAAC-based approach
- Galectin-9 in combination with Rapamycin induces cardiac allograft tolerance in mice
- Rapamycin attenuates pulmonary allergic vasculitis in murine model by reducing TGF-β production in the lung
- Rapamycin in fibrotic diseases: beneficial or detrimental agent?
- Recovery from Rapamycin: drug-insensitive activity of yeast target of Rapamycin complex 1 (TORC1) supports residual proliferation that dilutes Rapamycin …
- Rapamycin and PF4 induce apoptosis by upregulating Bax and down-regulating survivin in MNU-induced breast cancer
- Synergistic anti-tumor effects of a novel phosphatidyl inositol-3 kinase/mammalian target of Rapamycin dual inhibitor BGT226 and gefitinib in non-small cell lung …
- Down regulation of mammalian target of Rapamycin decreases HIF-1α and survivin expression in anoxic lung adenocarcinoma A549 cell to elemene and/or irradiation
- Efficacy and safety of Rapamycin in treatment of children with epilepsy complicated with tuberous sclerosis
- Oral erlotinib, but not Rapamycin, causes modest acceleration of bladder and hindlimb recovery from spinal cord injury in rats
- p21WAF1/CIP1 expression is differentially regulated by metformin and Rapamycin
- Alcohol consumption mitigates apoptosis and mammalian target of Rapamycin signaling in myocardium
- Insights from yeast into whether the Rapamycin inhibition of heat shock transcription factor (Hsf1) can prevent the Hsf1 activation that results from treatment …
- Immunotherapy with tolerogenic dendritic cells alone or in combination with Rapamycin does not reverse diabetes in NOD mice
- Mammalian target of Rapamycin complex 2 signaling pathway regulates transient receptor potential cation channel 6 in podocytes
- Successful mammalian target of Rapamycin inhibitor maintenance therapy following induction chemotherapy with gemcitabine and doxorubicin for metastatic …
- Anti‐LFA‐1 or Rapamycin overcome costimulation blockade‐resistant rejection in sensitized bone marrow recipients
- Interferon alpha and Rapamycin inhibit the growth of carcinoid and medullary thyroid cancer in vitro
- In vitro and in vivo evaluation of Rapamycin-eluting nanofibers coated on cardia stents
- Rapamycin does not inhibit human cytomegalovirus reactivation from dendritic cells in vitro
- eIF4E-Overexpression imparts perillyl alcohol and Rapamycin-mediated regulation of telomerase reverse transcriptase
- Clinical significance of aberrant mammalian target of Rapamycin expression in stage IIIB colon cancer
- Multifaceted aging and Rapamycin
- Effect of Rapamycin on spleen size in longstanding renal transplant recipients
- Congenital segmental lymphedema in tuberous sclerosis complex with associated subependymal giant cell astrocytomas treated with mammalian target of Rapamycin …
- Effect of Rapamycin-induced tumor vessel thrombosis combined with docetaxel in non-small-cell lung cancer
- MicroRNA-100 promotes migration and invasion through mammalian target of Rapamycin in esophageal squamous cell carcinoma
- Abstract C252: A phase 1, dose-escalation study of MLN0128, an investigational oral mammalian target of Rapamycin complex 1/2 (mTORC1/2) catalytic inhibitor, in …
- Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis
- Mammalian target of Rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism
- Sequential use of mammalian target of Rapamycin inhibitors in patients with metastatic renal cell carcinoma following failure of tyrosine kinase inhibitors
- The effects of viscosity and aeration rate on Rapamycin production in an airlift bioreactor by using Streptomyces hygroscopicus
- Virtual screening and biochemical evaluation to identify new inhibitors of mammalian target of Rapamycin (mTOR)
- Genetic Findings in Obsessive–Compulsive Disorder Connect to Brain‐Derived Neurotropic Factor and Mammalian Target of Rapamycin Pathways: Implications for …
- Limited significance of activated Akt-mammalian target of Rapamycin signaling pathway in prostate cancer progression
- Fusogenic pH sensitive liposomal formulation for Rapamycin: improvement of antiproliferative effect
- The synergistic effect of Rapamycin combined with 5-fluorouracil in BALB/cByJNarl mice bearing CT-26 tumor cells
- Transcriptome profiling of CTLs regulated by Rapamycin using RNA-Seq
- Application of Response Surface Methodology To Formulation Optimization of Rapamycin Loaded Magnetic Fe3O4/Carboxymethylchitosan Nanoparticles
- Dual inhibition of phosphatidylinositol 3′-kinase and mammalian target of Rapamycin using NVP-BEZ235 as a novel therapeutic approach for mucinous …
- Rapamycin increases neuroblastoma xenograft and host stromal derived osteoprotegerin inhibiting osteolytic bone disease in a bone metastasis model
- Signaling mechanisms that suppress the cytostatic actions of Rapamycin
- Identification of the novel interacting partners of the mammalian target of Rapamycin complex 1 in human CCRF-CEM and HEK293 cells
- … augment resistance exercise–induced increases in phosphatidylinositol 3 kinase/protein kinase B–mammalian target of Rapamycin pathway markers indicative of …
- Rapamycin represses myotube hypertrophy and preserves viability of C2C12 cells during myogenesis in vitro
- Dedifferentiated adenoid cystic carcinoma of the trachea: a case report with respect to the immunohistochemical analyses of mammalian target of Rapamycin pathway …
- Distinct sensitivity of CD8+ CD4− and CD8+ CD4+ leukemic cell subpopulations to cyclophosphamide and Rapamycin in Notch1-induced T-ALL mouse model
- Chronic intermittent hypoxia increases β cell mass and activates the mammalian target of Rapamycin/hypoxia inducible factor 1/vascular endothelial growth factor A …
- … of thrones” in metastatic renal cell carcinoma: vascular endothelial growth factor-tyrosine kinase inhibitors and mammalian target of Rapamycin inhibitors battling for …
- Dietary protein decreases exercise endurance through Rapamycin-sensitive suppression of muscle mitochondria
- Characterization of residue-dependent differences in the peripheral membrane association of the FATC domain of the kinase ‘target of Rapamycin‘by NMR and …
- hcrcn81 is upregulated by Rapamycin treatment in human colorectal adenocarcinoma cells
- Role of Mammalian Target of Rapamycin (mTOR) in muscle growth
- Contrasting effects of chronic, systemic treatment with mTOR inhibitors Rapamycin and metformin on adult neural progenitors in mice
- Inhibitory effect and significance of Rapamycin on the mammalian target of Rapamycin signaling pathway in osteosarcoma stem cells and osteosarcoma cells
- Crosstalk between Edc4 and mammalian target of Rapamycin complex 1 (mTORC1) signaling in mRNA decapping
- Protein kinase C and P2Y12 take center stage in thrombin‐mediated activation of mammalian target of Rapamycin complex 1 in human platelets
- Significance of mTOR (mammalian target of Rapamycin) activity in human lymphomas
- Combination treatment with asiaticoside and Rapamycin: A new hope for in‑stent restenosis
- EGF signalling and Rapamycin-mediated mTOR inhibition in glioblastoma multiforme evaluated by phospho-specific flow cytometry
- MicroRNAs and the cellular response to Rapamycin: potential role in diagnosis and therapy
- Expression of set is downregulated by Rapamycin in human colorectal cancer cells
- Reactivation versus clearance of Mycobacterium tuberculosis using mammalian target of Rapamycin inhibitors in patients with cancer can be context dependent
- Rapamycin inhibition of CFA-induced lymphangiogenesis in PLN is independent of mast cells
- Short-course Rapamycin treatment preserves airway epithelium and protects against bronchiolitis obliterans
- Telomerase expression abrogates Rapamycin-induced irreversible growth arrest of uterine fibroid smooth muscle cells
- Rapamycin enhances adenovirus-mediated cancer imaging and therapy in pre-immunized murine hosts
- Effects of Rapamycin on DC-SIGN expression and biological functions in DC
- Differential gene expression profile of first-generation and second-generation Rapamycin-resistant allogeneic T cells
- Expression of mammalian target of Rapamycin in atherosclerotic plaques is decreased under diabetic conditions: A mechanism for Rapamycin resistance
- Mammalian target of Rapamycin complex 1 as an inducer of neurotrophic factors in dopaminergic neurons
- … shows requirement of two processes: a destabilization of eIF4E: 4E-BP complex and a great stimulation of the 4E-BP-degradation mechanism, both Rapamycin …
- A window into immunosuppressant immunoregulation: recipient conversion to Rapamycin increases potentially tolerogenic immune cells
- A novel strategy inducing autophagic cell death in Burkitt’s lymphoma cells with anti-CD19-targeted liposomal Rapamycin
- Differential role of Rapamycin and torin/KU63794 in inflammatory response of 264.7 RAW macrophages stimulated by CA-MRSA
- Rapamycin decreases expression of thymidylate synthase and enhances the response to pemetrexed in preclinical studies and a Phase I/II clinical study of subjects …
- Effects of Rapamycin on airway remodeling in asthmatic mice
- Interleukin‐15 gene therapy and the mammalian target of Rapamycin inhibitor everolimus inhibit the growth of metastatic breast cancer
- Effects of Rapamycin on biological characteristics of bone marrow mesenchymal stem cells from patients with aplastic anemia
- Rapamycin promotes podocyte migration through the up-regulation of urokinase receptor
- … of the face, similar to tuberous sclerosis complex-associated angiofibroma, shows activation of the mammalian target of Rapamycin pathway: evidence for a …
- Kruppel-like factor 2 might mediate the Rapamycin-induced arterial thrombosis in vivo: implications for stent thrombosis in patients.
- Molecular insights into the stabilization of protein–protein interactions with small molecule: The FKBP12–Rapamycin–FRB case study
- Mammalian target of Rapamycin: a novel pathway in vascular calcification
- Improvement of microbial strain and fermentation process of Rapamycin biosynthesis
- Temporary placement of a paclitaxel or Rapamycin-eluting stent is effective to reduce stenting induced inflammatory reaction and scaring in benign cardia …
- Combined antiangiogenic and mammalian target of Rapamycin inhibitor targeted therapy in metaplastic breast cancer harboring a PIK3CA mutation
- Enhanced genetic modification of adult growth factor mobilized peripheral blood hematopoietic stem and progenitor cells with Rapamycin
- inhibition of intimal hyperplasia by local perivascular application of Rapamycin and imatinib mesilate after carotid balloon injury
- Mammalian target of Rapamycin inhibitor abrogates abnormal osteoclastogenesis in neurofibromatosis type 1
- Rapamycin: Current and Future Uses
- Attenuation of the activated mammalian target of Rapamycin pathway might be associated with renal function reserve by a low-protein diet in the rat remnant kidney …
- Combination of Rapamycin and Imatinib in Treating Refractory Chronic Myeloid Leukemia Myeloid Blast Crisis: a Case Report025B3
- A new Rapamycin-abluminally coated chitosan/heparin stent system accelerates early re-endothelialisation and improves anti-coagulant properties in porcine coronary …
- Rapamycin helps to maintain colony forming efficiency in corneal epithelial cells
- Influence of GABA on brain protein synthesis mediated by the mammalian target on the Rapamycin pathway
- Establishment of an orthotopic mouse non-muscle invasive bladder cancer model expressing the mammalian target of Rapamycin signaling pathway
- Loss of hydrophobic motif and activation loop phosphorylation is a consequence and not the mechanism of S6 kinase 1 inhibition by Rapamycin.
- Activation of mammalian target of Rapamycin signaling pathway markers in minute adenocarcinoma of the prostate
- Mammalian target of Rapamycin (mTOR) inhibition does not prevent lung adenocarcinoma‐induced malignant pleural effusion
- Prophylaxis for Post-Traumatic Epilepsy: Can Your Kinase Do That? inhibition of Epileptogenesis with Rapamycin
- Balloon coating with Rapamycin using an on-site coating device
- Acute Rapamycin (RAP) exposure induce developmental, neurobehavioral and immunal toxicities in embryonic zebrafish
- … determination of GDC-0980 (Apitolisib), a dual small-molecule inhibitor of class 1A phosphoinositide 3-kinase and mammalian target of Rapamycin, in human plasma
- The yeast 14-3-3 proteins Bmh1 and Bmh2 differentially regulate Rapamycin-mediated transcription
- Downregulation of RelA (p65) by Rapamycin inhibits murine adipocyte differentiation and reduces fat mass of C57BL/6J mice despite high fat diet
- Dietary Rapamycin selectively improves arterial function in old mice
- Designing and in-vitro characterization of micelle forming amphiphilic PEGylated Rapamycin nanocarriers for the treatment of gastric cancer.
- A functional autophagy pathway is required for Rapamycin-induced degradation of the Sgs1 helicase in Saccharomyces cerevisiae
- Selective Substitution of 31/42–OH in Rapamycin Guided by an in Situ IR Technique
- Calcineurin inhibitor conversion to Rapamycin can improve graft function in living donor kidney transplantation with older donors
- Preventing primate GvHD using a novel antagonistic anti-CD28 antibody plus Rapamycin: downregulation of CD8 activation and preservation of the naïve cell …
- Designing and In-Vitro Characterization of Micelle Forming Amphiphilic PEGylated Rapamycin Nanocarriers for the Treatment of Gastric Cancer
- Activation of mammalian target of Rapamycin (mTOR) in human restenosis
- Centenarian lamins: Rapamycin targets in longevity
- The immunosuppressant tributyltin oxide blocks the mTOR pathway, like Rapamycin, albeit by a different mechanism
- Rapamycin down‐regulates REDD1 to blunt cell death: a potential way to maintain retinal ganglion cell function as in glaucoma
- Mechanism for the synergistic effect of Rapamycin and resveratrol on hyperinsulinemia may involve the activation of protein kinase B
- Enrichment of soymeal medium to increase the Rapamycin production by Streptomyces hygroscopicus
- Predictive value of phosphorylated mammalian target of Rapamycin for disease‑free survival in breast cancer patients receiving neoadjuvant chemotherapy
- Rapamycin for the treatment of refractory extensive chronic graft-versus-host disease
- Effects of Rapamycin on expression of ten kinds autophagy-related miRNAs in RAW264. 7 macrophages
- Rapamycin‐responsiveness and Gln3‐Tor1 interaction are associated with different target sites on the Gln3 protein (609.13)
- Effect of intrathecal Rapamycin on diabetic neuropathic pain in rats
- Incidence and risk of treatment-related mortality in patients with renal cell cancer (RCC) and non-RCC treated with mammalian target of Rapamycin (mTOR) inhibitors.
- Expression and clinical significance of serine-threonine kinase/mammalian target of Rapamycin/p70 S6K signal pathway in oral squamous cell carcinoma.
- Rapamycin to the rescue
- Hyper-Activation of the Target of Rapamycin (Tor) Kinase 1 Decreases Intracellular Glutathione Content in Saccharomyces cerevisiae as Revealed by LC-MS/MS …
- P7170, a novel inhibitor of phosphoinositide 3-kinase (PI3K)-mammalian target of Rapamycin (mTOR) and activin receptor-like kinase 1 (ALK1) shows anti-tumor …
- Inhibitory effect of Rapamycin on the proliferation of Rhesus retinal vascular endothelial cells
- Hanga Roa Hospital and Rapamycin
- BG-12 (DIMETHYL fumarate) is neuroprotective in the murine cuprizone/Rapamycin model of demyelination and neurodegeneration (P05. 184)
- Anticancer benefits of early versus late use of Rapamycin in a rat model of urothelial carcinoma
- Rapamycin improves learning and memory ability in ICR mice with pilocarpine-induced temporal lobe epilepsy
- Icotinib combined with Rapamycin in a renal transplant recipient with epidermal growth factor receptor‑mutated non‑small cell lung cancer: A case report
- Hepatoprotective effect of Rapamycin in rats with obstructive jaundice
- Effect of chemotherapy with cisplatin and Rapamycin on HeLa cells in vitro
- Phosphatidylinositol-3 kinase-Akt-mammalian target of Rapamycin signaling pathway mediates contractility of human endometriotic stromal cells: A promising …
- Antimycin induces apoptosis in Rapamycin resistant SW620 colorectal cancer cells
- Novel stratification of the recurrence risk following surgical extirpation of clear cell renal cell carcinoma using tissue biomarkers in the mammalian target of Rapamycin …
- The effects of mammalian target of Rapamycin inhibitors on serum uric acid levels in renal transplant patients
- Chronic Rapamycin treatment decreases markers of autophagy and mitophagy in a sex‐specific manner (1094.8)
- Risk evaluation and mitigation strategies: a focus on the mammalian target of Rapamycin inhibitors
- Effects of Rapamycin on Dia2 in S. cerevisiae
- Neointima reduction with IVUS and Rapamycin microbubbles: In Vivo swine model results
- inhibition of mammalian target of Rapamycin induces renal mitochondrial uncoupling in rats
- Mammalian target of Rapamycin regulates androgen receptor and Akt phosphorylation in prostate cancer 22RV1 cells
- Targeting the mammalian target of Rapamycin pathway in osteosarcoma using combinative chemotherapy
- Different Responses of Neointimal Cells to Imatinib Mesylate and Rapamycin Compared with Normal Vascular Smooth Muscle Cells
- Interacting to control size: the roles of juvenile hormone, insulin/target of Rapamycin and ecydsone signaling in regulating body size in Drosophila.
- Top-Accessed Article: Topical Rapamycin
- Critical analysis of the potential for therapeutic targeting of mammalian target of Rapamycin (mTOR) in gastric cancer
- Interferon‑α enhances the susceptibility of renal cell carcinoma to Rapamycin by suppressing mTOR activity
- Influence of Rapamycin on Zea Mays Seedlings
- Resistant mechanism about Rapamycin and solution
- RhoA regulates the mechanistic target of Rapamycin complex 1 (mTORC1)
- Effect of Rapamycin on pulmonary fibrosis in rats
- Global Proteomics remodeling of cardiac aging and pressure-overload induced heart failure is attenuated by suppression RF target of Rapamycin
- Acquired resistance to Rapamycin and mTOR kinase inhibitors is mediated by non-overlapping mutations in distinct sites in the mTOR protein
- Effect of Rapamycin on the potential metastasis of squamous cell carcinoma in vitro
- Effects of mammalian-target-of-Rapamycin pathway on lapatinib resistance in breast cancer MDA-MB-231 cells
- A randomized phase II study (B2151005) of the intravenous phosphatidylinositol 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) inhibitor PF-05212384 plus …
- B7-H1 Expression Is Critical to Cardiac Allograft Tolerance Induced By the Combination Therapy of Mesenchymal Stem Cells and Rapamycin.: Abstract# 2272
- Use of mammalian target of Rapamycin inhibitor for treating pathologies including neurodegenerative diseases (Alzheimer’s disease), neuroinflammatory diseases and …
- Involvement of Mammalian Target of Rapamycin Complexes in GM3 Mediated Melanoma Metastasis
- Effects of Rapamycin on growth, apoptosis, and DDAH2 expression in liver cancer cells
- Regulation of gene expression of mammalian target of Rapamycin
- Effect of gluteus medius muscle sample collection depth on postprandial mammalian target of Rapamycin signaling in mature Thoroughbred mares
- Abstract B18: Targeting Rapamycin-induced autophagy in cancer
- … unprotected left main. Mid term results from a Prospective, Multicenter and Controlled Argentina Registry with a Cobalt-Chromium Rapamycin Eluting Stent, FIREBIRD …
- Epithelial to mesenchymal transition and Rapamycin sensitivity in cancer cell lines.
- Regulation of the Mechanistic Target of Rapamycin by Cellular Stress.
- Chronic Rapamycin Treatment Confers Partially Reversible Diabetes Mellitus
- Rapamycin promotes Glt1 expression and glutamate uptake inastrocyte
- Modulation of endothelial cell-T cell interactions by Rapamycin
- Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of Rapamycin (mTOR).
- Periadventitial Application of Rapamycin-Loaded Nanoparticles Produces Sustained inhibition of
- Mammalian Target of Rapamycin (mTOR)
- Rapamycin As Treatment Of Lymphangioleiomyomatosis: Favorable Response In Different Clinical Manifestations
- Regulation of the Target of Rapamycin Signaling Pathway in Saccharomyces cerevisiae
- Effects of Rapamycin on atrial fibrosis in rats
- Effects of Rapamycin on Monocytes from Pediatric Patients with Tuberous Sclerosis
- Topical Rapamycin as a Treatment for Fibrofolliculomas in Birt-Hogg-Dubé
- Effects of Rapamycin on proliferation of EC9706 cells transfected with p70S6K-siRNA
- Research progress on feedback activation mechanism of mammalian target of Rapamycin in tumors
- Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the
- Perillyl alcohol and Rapamycin‐mediated inhibition of migration and invasion
- Effect of Rapamycin in Proliferation and Apoptosis of Human Tongue Squamous Cell Carcinoma
- Effects of Rapamycin combined with rosiglitazone on lung injury in septic rats
- A novel way for neurodegenerative diseases within cell and animal model by autophagy induced with Rapamycin treatment
- An aqueous clear Rapamycin topical drop for retinal delivery
- P442 COMPARISON OF THE INHIBITORY EFFECTS OF Rapamycin ON THE DIFFERENT STAGES OF HEPATIC FIBROSIS
- Determinants of sensitivity and resistance to Rapamycin-chemotherapy drug combinations in vivo. Cancer Res
- The protective role of mammalian target of Rapamycin in the injury of podosytes induced by adriamycin
- Rapamycin-resistant HIF-1α expression in hepatocellular carcinoma (HCC) cells and high sensitivity of endothelial cells within HCC tissues to Rapamycin.
- Investigation into the effects and mechanisms of Rapamycin treatment in two mouse models of Complex I-deficient neurological pathology
- TCT-837 Everolimus-eluting versus other Rapamycin derivatives-eluting stents in patients with coronary artery disease: a meta-analysis of 16 randomized trials
- Rapamycin Augments Dendritic Cell Mediated Tumor Immunity
- Novel Heregulin-Mediated Pathways To Mammalian Target Of Rapamycin Complex 1
- B58 EXPERIMENTAL MODELS OF PULMONARY HYPERTENSION II: inhibition Of mTOR By Rapamycin Blocks Systemic Angiogenesis
- P101 The effect of Rapamycin in cardiac mTORC2-deficient mice under pressure overload conditions.
- A in vivo Study on the Neuroprotective Effects of Rapamycin Against Neurotoxic Aβ in Rats
- … between the risk grade of gastrointestinal stromal tumor and expression of mammalian target of Rapamycin and phosphorylated mammalian target of Rapamycin
- Addition of Rapamycin to Anti-CD3 Antibody Improves Long-Term Glycaemia Control in
- The phosphatidyl-inositol 3-kinase/Akt/mammalian target of Rapamycin pathway as a therapeutic target in head and neck cancer
- Mammalian Target of Rapamycin in Renal Cell Carcinoma
- Dynamical models of the mammalian Target of Rapamycin network in ageing
- Effects of Rapamycin administration on the diabetic rat placenta and embryo
- Induction of central memory to BCG vaccine in mice through Rapamycin (P4300)
- Differential Effects of Rapamycin Treatment on Cardiac Pathology in Lean and Obese Rats
- The mechanistic target of Rapamycin pathway in sarcomas: from biology to therapy
- Reperfusion Therapy With Rapamycin Protects Type 2 Diabetic Mouse Heart
- Effect of Rapamycin Combined with Cisplatin on Apoptosis and Autophagy of Ovarian Cancer Cell Line SKOV3
- mTOR Inhibitor MLN0128 has Antitumor Efficacy in Cell Lines With Intrinsic and Acquired Rapamycin-Resistance.
- Rapamycin Effects on Antigen-Specific CD8 T cell Migration
- Medium-and long-term efficacy and safety of domestic and imported Rapamycin-eluting stents
- Rapamycin Induced Autophagy and Suppression in Human Leukemia Cells Proliferation
- Role of mammalian target of Rapamycin in ischemia‐reperfusion induced kidney injury (692.11)
- Cargo and Carrier Effects of Rapamycin-Loaded Perfluorocarbon Nanoparticles
- Treating brain tumors with targeted-micelles containing Rapamycin
- Mammalian target of Rapamycin inhibitors: the beginning of the end or the end of the beginning?
- Effects of cyclosporine A and Rapamycin on the ability of dendritic cells to activate T cells
- Experimental study on intraocular posterior capsule opacification in intraocular lens treated by Rapamycin
- The Ure2 αCap Is Required for GATA Factor Responses to Rapamycin, But Not Nitrogen Limitation
- Mammalian target of Rapamycin inhibitors for heart transplant patients
- Rapamycin INHIBITS THORACIC AORTIC ANEURYSM FORMATION THROUGH SUPPRESSION OF PRO-INFLAMMATORY MEDIATORS
- Outcome Of Rapamycin Therapy For Post Transplant-Lymphoproliferative Disorder After Kidney Transplantation: Case Series
- The protective effects of Rapamycin on intestinal ischemia/reperfusion induced remote lung injury in mice
- mTOR inhibitor MLN0128 Has antitumor efficacy in cell lines with intrinsic and acquired Rapamycin resistance in vitro and in vivo.
- Long-term effectiveness and safety of Rapamycin-eluting stents in percutaneous coronary intervention of patients with coronary artery disease
- Abstract A35: Identification of pro-survival Rapamycin-dependent microRNA (Rapa-miRs) in tuberous sclerosis complex
- EFFECTS OF THE ANTI-AGING AGENT Rapamycin ON DISC MATRIX HOMEOSTASIS: GP75.
- Mammalian target of Rapamycin inhibitors permit regulatory T cell reconstitution and inhibit experimental chronic graft-versus-host disease
- The mammalian target of Rapamycin regulates lipid metabolism in osteoarthritic human articular cartilage
- Abstract B035: Preneoplastic transformation of murine mammary stem cells by aging and inhibition by Rapamycin
- Rapamycin prevents cadmium-induced neuronal cell death via suppressing MAPK and Akt/mTOR network
- Prevention of murine sclerodermatous chronic graft-versus-host disease by Rapamycin
- Topical Rapamycin for the treatment of facial angiofibromas with tuberous sclerosis complex
- Correction: Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome
- B57 EXPERIMENTAL MODELS OF PULMONARY HYPERTENSION I: Effects Of Rapamycin On Pulmonary Vascular Remodeling Of Allergic Vasculitis In Murine …
- Rapamycin reduces podocyte adhesion damage caused by sublytic C5b-9 via autophagy activation
- Mammalian target of Rapamycin (mTOR): Structure, signaling pathways and biological effects
- Porous Silicon Microparticle Formulation as an Intravitreal Delivery System for Rapamycin
- Effect Of Long Term Rapamycin Treatment On mTOR Signalling Network In Colon And Liver Of C57bl/6 Mice
- Synergistic Effects of Metformin in Combination with Rapamycin on Hepatocellular Carcinoma Cell Lines
- Related research in mammalian target of Rapamycin signaling pathway and autophagy.
- Rapamycin inhibits proliferation of human stomach cancer SGC-7901 cell line in vetro via downregulation of HIF-1α and VEGF
- Perivascular Administration of Rapamycin Through Nanoparticles Prolongs inhibition of Arterial Restenosis
- Abstract A163: A diverse array of mutations in mTOR are hyperactivating and correlate with Rapamycin sensitivity.
- Developing a mouse model to study the metabolic role of the mammalian target of Rapamycin complex 1 in adipose tissue
- Rapamycin increases radiosensitivity of cancer cells by induction of premature senescence.
- Effect of LY294002 and Rapamycin on bim and bax in coxsackievirus B3 induced HeLa cells
- Regulation of protein deposition by mammalian target of Rapamycin in piglets.
- Rapamycin FOR THE TREATMENT OF AUTO-ANTIBODY INDUCED HAEMOLYSIS, IN A PATIENT WITH Β-THALASSEMIA MAJOR
- Effect of NVP-BEZ235, dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor, on radiosensitivity of oral cancer cell line through G2/M phase …
- The role of mammalian target of Rapamycin (mTOR) in macrophage polarization
- Rapamycin‐Regulated Ubiquitin Specific Peptidases Expression in Cardiocytes
- Different distribution and expression of mammalian target of Rapamycin complex in the kidney of diabetic nephropathy mice
- … MECHANISMS OF RIGHT VENTRICULAR DYSFUNCTION: Worsening Right Ventricular Dysfunction By Fueling An Impaired Autophagic Flux With Rapamycin
- Rapamycin is a chemopreventive and chemotherapeutic agent for ras-driven epidermal squamous cell carcinoma: evidence from mouse models.
- mTOR inhibition by Rapamycin Alleviates Mitochondrial Disease in the Ndufs4-Mouse Model of Leigh Syndrome
- Activation of mammalian target of Rapamycin contributes to rat nociceptive behaviors
- Reperfusion Therapy With Rapamycin in Diabetic Heart: Essential Role of STAT3 Signaling
- The role of mammalian target of Rapamycin (mTOR) in skin carcinogenesis
- Activation of mammalian target of Rapamycin complex 1 (m TORC1) impairs urine concentration in mice
- Distribution and significance of mammalian target of Rapamycin during differentiation of rat bone marrow mesenchymal stem cells into neurons
- Correction: Beneficial Role of Rapamycin in Experimental Autoimmune Myositis
- The effect of FK506 and Rapamycin on the expression of Foxp3+ Treg in liver cancer patients undergoing liver transplant and its clinical relevance
- Effect study of Rapamycin on the expression of tumor helicase RECQ1 in glioma patients
- Mammalian Target of Rapamycin (mTOR) Activity Dependent Phospho-Protein
- Activation and its clinical significance of the mammalian target of Rapamycin pathway and its downstream proteins in gastric cancer
- Activation and its clinical significance of the mammalian target of Rapamycin pathway and its downstream proteins in gastric cancer
- Chronic Rapamycin Treatment Improves Cardiac Function by Attenuating Oxidative Stress and Altering Contractile Proteins in Type 2 Diabetic Mice
- Retraction: Mammalian target of Rapamycin inhibitors for treatment in tuberous sclerosis
- Rapamycin induces neuronal differentiation and decreases prion-like proteins in human glioblastoma cell cultures
- SYSTEMIC Rapamycin TO PREVENT IN-STENT STENOSIS IN PERIPHERAL PULMONARY ARTERIAL DISEASE: EARLY CLINICAL EXPERIENCE
- Build of lentiviral mediated RNA interference of mammalian target of Rapamycin
- Effects of Rapamycin on the expression of HGF and TGF—β in chronic renal fibrosis of rats
- A67 CLINICAL AND CELLULAR ASPECTS OF LYMPHANGIOLEIOMYOMATOSIS: Rapamycin As Treatment Of Lymphangioleiomyomatosis: Favorable Response In …
- Tyrosine kinase inhibitors and mammalian target of Rapamycin inhibitors related to cardiac toxicity
- Rapamycin Restores Cerebral Blood Flow and Blood Brain Barrier Integrity in APOE4 Carriers
- Rapamycin Ameliorates Renal Ischemia/Reperfusion Injury via Remodeling Immune Microenvironment. SM J Urol. 2015; 1 (2): 1010
- Iron Metabolism and Rapamycin (sirolimus)-Induced Microcytic Anemia in Renal Transplant Patients
- The Role of the Mammalian Target of Rapamycin (mTOR) in Cytotoxic T Lymphocytes
- Rapamycin Promotes Expansion of CD4+ CD25+ FOXP3+ Regulatory T Cells by Modulating Fatty Acid Metabolism?
- Rapamycin modulates anti-and pro-thrombotic gene expressions via Kruppel-like factor 2: in vitro studies
- Biology of Renal Cell Carcinoma (Vascular Endothelial Growth Factor, Mammalian Target of Rapamycin, Immune Aspects)
- Subacute Treatment With Rapamycin Reverses Cardiac Aging by Proteome Remodeling and Improved Mitochondrial Energy Metabolism
- Rapamycin Attenuates Cardiac Expression of Anti‐inflammatory AT2R and Anti‐Apoptotic MCL1
- Regulation of the mammalian target of Rapamycin signaling by grape polyphenols in breast cancer (766.6)
- Mammalian Target of Rapamycin Inhibitors Permit Regulatory T Cell Reconstitution
- OP0285 Liver Mitochondria Dysfunction Precedes the Onset of SLE in Lupus-Prone Mice and is Ameliorated by Rapamycin and 3-Pehpc
- Rapamycin Suppresses Astrocytic and Microglial Activation and Reduced Development of Neuropathic Pain after Spinal Cord Injury in Mice.
- Npr2 regulates autophagy via Gtr1‐Gtr2‐dependent target of Rapamycin complex 1 signaling (539.11)
- Rapamycin combined with atorvastatin attenuate oxidative stress injury in rat vascular smooth muscle cells.
- Chronic Treatment With Novel Nanoformulated Micelles of Rapamycin, Rapatar, Protects Diabetic Heart Against Ischemia/reperfusion Injury
- Targeting multiple components of the mammalian target of Rapamycin (mTOR) signaling: A novel combination therapy to improve pancreatic cancer treatment.
- Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function
- Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib
- The Mammalian Target of Rapamycin Activation is Required for Monocyte Proinflammatory Response in Patients with Coronary Artery Disease
- Expression and its clinical significance of mammalian target of Rapamycin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine neoplasm
- Expression and its clinical significance of mammalian target of Rapamycin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine neoplasm
- Rapamycin enhances the TNF-α-induced secretion of IL-6 and IL-8 by suppressing PDCD4 degradation in orbital fibroblasts
- Rapamycin Promotes Expansion of CD4+ CD25+ FOXP3+ Regulatory T Cells By Modulating Fatty Acid Metabolism?: Abstract# D2799
- Rapamycin Ameliorates Proteinuria and Restores Nephrin and Podocin Expression in Experimental Membranous Nephropathy
- Elucidating The Regulatory Mechanisms Of The Mammalian Target Of Rapamycin Complex 1 (mTORc1) In Protein Homeostasis
- Rapamycin promotes memory CD8 T cell development by regulating the Bim/Bcl-2 balance
- Intra-articular administration of gelatin hydrogels incorporating Rapamycin-micelle reduces development of experimental osteoarthritis in a murine model
- Research progress on the regulation of milk protein synthesis by essential amino acids through mammalian target of Rapamycin signaling pathway.
- Hypoxia Regulation of Sensitivity to the Mechanistic Target of Rapamycin Kinase inhibition (mTORki) in Glioblastoma Multiforme
- Rapamycin Expands and Confers Resistance to Apoptosis of Human Inducible Regulatory T Cells (TRI)
- A Diverse Array of Cancer-Associated mTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
- A Diverse Array of Cancer-Associated mTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
- Rapamycin can overcome ABT-737 resistance in patient-derived SCLC xenograft models.
- gln3 Mutations Dissociate Responses to Nitrogen Catabolite Repression and Rapamycin inhibition of TorC1
- inhibition of the mammalian Target of Rapamycin (mTOR) does not alter nitric oxide or superoxide levels in human skin
- Evidence that chronic inhibition of the mammalian Target of Rapamycin (mTOR) reduces skin blood flow in humans
- Experimental study on the preventive effect of paclitaxel and Rapamycin composite drug-eluting stent on coronary restenosis in minipigs
- Induction of Autophagy with Rapamycin overcomes Bcl‐2’s deleterious effects on stroke outcome
- Donor Specific Transfusion Combined With Anti-CD134L and Rapamycin Inhibits Accelerated Rejection Mediated By Alloantigen-Primed Memory Cells in Mice …
- Oral Rapamycin (eRapa) safely prevents carcinogen-induced dermal carcinogenesis through an interferon-γ-dependent mechanism (TUM7P. 931)
- Rapamycin Can Reduce Apoptosis of CD4+ CD25+ Regulatory T Cells from Mouse Model of Severe Aplastic Anemia
- Combination Of Regulatory T Cells and Rapamycin As Treatment For Experimental Chronic Graft-Versus-Host Disease
- Rapamycin, an inhibitor of mTOR signaling pathway, reverses lithium‐induced cell proliferation in renal collecting ducts
- The Mammalian Target of Rapamycin Complex 2 in Angiogenesis: An in vitro Analysis Using The Endothelial Tube Formation Assay
- inhibition of mTOR With Rapamycin Reverses Cardiomyocyte-Specific Knockout of Pten-Induced Hypertrophic Cardiomyopathy
- Efficient Induction and Expansion Of CD8+ CD28+ Foxp3+ Regulatory T Cells By TGF-beta1 and Rapamycin
- Rapamycin-induced renal magnesium wasting associates with decreased TRPM6 expression and EGF stimulation
- Rapamycin modulates the course of hepatitis B virus (HBV) infection in hydrodynamic injection mouse model: the role of Treg in HBV persistence
- Effects of Rapamycin on granulation formation in response to centrally doubled coiled stents as a tracheal substitute
- … I: Selective Tsc1 Deletion In Smooth Muscle Results In mTOR Signaling Activation And Development Of Pulmonary Hypertension That Can Be Reversed By Rapamycin
- Investigation of a Putative Role for the Protein Kinase TOR (Target of Rapamycin) in microRNA-Mediated Gene Silencing in Drosophila Melanogaster
- Effects of Rapamycin on transforming growth factor-β2-induced epithelial-myofibroblast transition of human lens epithelial cells
- Impact of Rapamycin on phenotype and tolerogenic function of dendritic cells via intravital optical imaging
- Correlation between release of Rapamycin from Porous Silicon (pSi) and the color shifting of pSi monitored by a digital camera: a prototype of non-invasive …
- Polycystic Kidney Disease: Literature Review on the Mechanism of Mammalian Target of Rapamycin (mTOR) Inhibitors in the Reduction of Cyst Growth in Patients …
- Neuroprotective Effect of Rapamycin (Autophagy Enhancer) in Transgenic SOD1-G93A Mice of Amyotrophic Lateral Sclerosis
- Construction of a stable mouse fibroblast line targeting mammalian target of Rapamycin by lentivirus mediated short hairpin RNA
- Abstract A168: Hepatitis B virus pre-S2 mutant stimulates aerobic glycolysis through mammalian target of Rapamycin signaling in tumorigenesis.
- Activation of mammalian target of Rapamycin (mTOR) in triple negative feline mammary carcinomas
- Molecular basis of the Rapamycin insensitivity of target of Rapamycin complex 2
- Alternative Rapamycin treatment regimens mitigate the impact of Rapamycin on glucose homeostasis and the immune system
- The mechanistic target of Rapamycin: the grand conducTOR of metabolism and aging
- The enigma of Rapamycin dosage
- inhibition of the mechanistic target of Rapamycin (mTOR)–Rapamycin and beyond
- Transient Rapamycin treatment can increase lifespan and healthspan in middle-aged mice
- Toward Rapamycin analog (rapalog)-based precision cancer therapy
- Rapamycin‐mediated mTORC 2 inhibition is determined by the relative expression of FK 506‐binding proteins
- Activation of mTOR (mechanistic target of Rapamycin) in rheumatic diseases
- Rapamycin: an InhibiTOR of aging emerges from the soil of Easter Island
- Health effects of long-term Rapamycin treatment: the impact on mouse health of enteric Rapamycin treatment from four months of age throughout life
- How longevity research can lead to therapies for Alzheimer’s disease: The Rapamycin story
- Rapamycin and rapalogs for tuberous sclerosis complex
- Rapamycin in aging and disease: maximizing efficacy while minimizing side effects
- Rapamycin blocks induction of the thermogenic program in white adipose tissue
- New perspectives on mTOR inhibitors (Rapamycin, rapalogs and TORKinibs) in transplantation
- Activation of the mechanistic target of Rapamycin in SLE: explosion of evidence in the last five years
- About-face on the metabolic side effects of Rapamycin
- Mammalian target of Rapamycin inhibition with Rapamycin mitigates radiation-induced pulmonary fibrosis in a murine model
- Nanomicellar topical aqueous drop formulation of Rapamycin for back-of-the-eye delivery
- Site-specific bioalkylation of Rapamycin by the RapM 16-O-methyltransferase
- Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects
- Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes
- Synergistic antitumor activity of Rapamycin and EF24 via increasing ROS for the treatment of gastric cancer
- Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts
- Mechanistic target of Rapamycin (mTOR) in tuberous sclerosis complex-associated epilepsy
- Dysregulation of mammalian target of Rapamycin signaling in mouse models of autism
- Intermittent administration of Rapamycin extends the life span of female C57BL/6J mice
- The opposing actions of target of Rapamycin and AMP-activated protein kinase in cell growth control
- Mammalian target of Rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia
- p53 and Rapamycin are additive
- Rapamycin enhances survival in a Drosophila model of mitochondrial disease
- Acute resistance exercise activates Rapamycin‐sensitive and‐insensitive mechanisms that control translational activity and capacity in skeletal muscle
- Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways
- Rapamycin increases neuronal survival, reduces inflammation and astrocyte proliferation after spinal cord injury
- Rapamycin inhibits tumor growth of human osteosarcomas
- Mammalian target of Rapamycin: its role in early neural development and in adult and aged brain function
- Rapamycin preserves gut homeostasis during Drosophila aging
- Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to Rapamycin
- Familial cortical dysplasia caused by mutation in the mammalian target of Rapamycin regulator NPRL3
- The combination of Rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells
- Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes
- Rapamycin protection of livers from ischemia and reperfusion injury is dependent on both autophagy induction and mammalian target of Rapamycin complex 2-Akt …
- Stem cell guidance through the mechanistic target of Rapamycin
- Target of Rapamycin complex 2 regulates actin polarization and endocytosis via multiple pathways
- Efficacy and safety of mammalian target of Rapamycin inhibitors in vascular anomalies: a systematic review
- Target of Rapamycin is a key player for auxin signaling transduction in Arabidopsis
- Metformin and Rapamycin reduce pancreatic cancer growth in obese prediabetic mice by distinct microRNA-regulated mechanisms
- Co-loaded paclitaxel/Rapamycin liposomes: development, characterization and in vitro and in vivo evaluation for breast cancer therapy
- Pharmacological inhibition of ULK1 kinase blocks mammalian target of Rapamycin (mTOR)-dependent autophagy
- Metformin potentiates Rapamycin and cisplatin in gastric cancer in mice
- Testing efficacy of administration of the antiaging drug Rapamycin in a nonhuman primate, the common marmoset
- Impact of Rapamycin on status epilepticus induced hippocampal pathology and weight gain
- Light-cleavable Rapamycin dimer as an optical trigger for protein dimerization
- Mutations in the mammalian target of Rapamycin pathway regulators NPRL2 and NPRL3 cause focal epilepsy
- Target of Rapamycin (TOR) plays a critical role in triacylglycerol accumulation in microalgae
- Rapamycin reduces severity of senile osteoporosis by activating osteocyte autophagy
- Mammalian target of Rapamycin inhibitors and clinical outcomes in adult kidney transplant recipients
- Co-delivery of Rapamycin-and piperine-loaded polymeric nanoparticles for breast cancer treatment
- Rapamycin alleviates oxidative stress-induced damage in rat erythrocytes
- 3D molecular MR imaging of liver fibrosis and response to Rapamycin therapy in a bile duct ligation rat model
- Rapamycin blocks the antidepressant effect of ketamine in task-dependent manner
- Rapamycin attenuates acute lung injury induced by LPS through inhibition of Th17 cell proliferation in mice
- Tomato FK506 binding protein 12KD (FKBP12) mediates the interaction between Rapamycin and target of Rapamycin (TOR)
- Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise
- The 4E-BP–eIF4E axis promotes Rapamycin-sensitive growth and proliferation in lymphocytes
- Recent advances in mammalian target of Rapamycin inhibitor use in heart and lung transplantation
- Mitochondrial quality control via the PGC1α-TFEB signaling pathway is compromised by parkin Q311X mutation but independently restored by Rapamycin
- … of resistance exercise training, matching deuterium oxide‐derived measures of muscle protein synthesis and mechanistic target of Rapamycin complex 1 signaling
- Oral mucosal injury caused by mammalian target of Rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice
- Subacute calorie restriction and Rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects
- Intermittent dosing of Rapamycin maintains antiepileptogenic effects in a mouse model of tuberous sclerosis complex
- Integration of transcriptomics and metabolomics data specifies the metabolic response of Chlamydomonas to Rapamycin treatment
- Rapamycin plays a neuroprotective effect after spinal cord injury via anti‐inflammatory effects
- Sqstm1 knock-down causes a locomotor phenotype ameliorated by Rapamycin in a zebrafish model of ALS/FTLD
- PAT4 levels control amino-acid sensitivity of Rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer
- Classic K aposi’s sarcoma treated with topical Rapamycin
- Optimization of a series of triazole containing mammalian target of Rapamycin (mTOR) kinase inhibitors and the discovery of CC-115
- Effect of metformin, Rapamycin, and their combination on growth and progression of prostate tumors in HiMyc mice
- Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism
- Blood–brain barrier leakage after status epilepticus in Rapamycin‐treated rats I: Magnetic resonance imaging
- Inhibiting the Mammalian target of Rapamycin blocks the development of experimental cerebral malaria
- Mitochondrial dysfunction in the liver and antiphospholipid antibody production precede disease onset and respond to Rapamycin in lupus‐prone mice
- Rapamycin inhibition of eosinophil differentiation attenuates allergic airway inflammation in mice
- Neuroprotective effect of Rapamycin on spinal cord injury via activation of the Wnt/β-catenin signaling pathway
- Rapamycin reduced ischemic brain damage in diabetic animals is associated with suppressions of mTOR and ERK1/2 signaling
- Local therapeutic efficacy with reduced systemic side effects by Rapamycin-loaded subcapsular microspheres
- The neuroprotective effect of Rapamycin as a modulator of the mTOR-NF-κB axis during retinal inflammation
- Cyclosporin a and Rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells
- Synergy between Rapamycin and FLT3 ligand enhances plasmacytoid dendritic cell–dependent induction of CD4+CD25+FoxP3+ Treg
- inhibition of mammalian target of Rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling
- TOR (target of Rapamycin) is a key regulator of triacylglycerol accumulation in microalgae
- Effect of chronic administration of low dose Rapamycin on development and immunity in young rats
- Effects of Rapamycin treatment on neurogenesis and synaptic reorganization in the dentate gyrus after controlled cortical impact injury in mice
- Chronic mTOR inhibition in mice with Rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice
- … N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of Rapamycin
- Rapamycin and chloroquine: the in vitro and in vivo effects of autophagy-modifying drugs show promising results in valosin containing protein multisystem …
- Targeted inhibition of rictor/mTORC2 in cancer treatment: a new era after Rapamycin
- Immune-stimulatory effects of Rapamycin are mediated by stimulation of antitumor γδ T cells
- Immunosuppression with mammalian target of Rapamycin inhibitor and incidence of post-transplant cancer in kidney transplant recipients
- … model of neuronopathic Gaucher disease demonstrates lysosomal-autophagic defects and altered mTOR signalling and is functionally rescued by Rapamycin
- Histone modifications change with age, dietary restriction and Rapamycin treatment in mouse brain
- Rapamycin improves palmitate-induced ER stress/NF κ B pathways associated with stimulating autophagy in adipocytes
- Rapamycin reveals an mTOR-independent repression of Kv1. 1 expression during epileptogenesis
- Intravitreal injection of Rapamycin-loaded polymeric micelles for inhibition of ocular inflammation in rat model
- Effects of Rapamycin pretreatment on blood-brain barrier disruption in cerebral ischemia-reperfusion
- Rapamycin attenuates aldosterone-induced tubulointerstitial inflammation and fibrosis
- The mammalian target of Rapamycin at the crossroad between cognitive aging and Alzheimer’s disease
- Cystinosin is a component of the vacuolar H+-ATPase-ragulator-rag complex controlling mammalian target of Rapamycin complex 1 signaling
- L-Tryptophan activates mammalian target of Rapamycin and enhances expression of tight junction proteins in intestinal porcine epithelial cells
- Skin expression of mammalian target of Rapamycin and forkhead box transcription factor O1, and serum insulin‐like growth factor‐1 in patients with acne vulgaris and …
- Rapamycin inhibits epithelial‐to‐mesenchymal transition of peritoneal mesothelium cells through regulation of Rho GTPases
- Platelet-derived growth factor regulates vascular smooth muscle phenotype via mammalian target of Rapamycin complex 1
- Phosphatidylinositol 3-kinase-AKT-mammalian target of Rapamycin (PI3K-Akt-mTOR) signaling pathway in non-small cell lung cancer
- Rapamycin protects against gentamicin-induced acute kidney injury via autophagy in mini-pig models
- Layer-by-layer-coated lyotropic liquid crystalline nanoparticles for active tumor targeting of Rapamycin
- Mammalian target of Rapamycin controls glucose consumption and redox balance in human Sertoli cells
- Yeast m6A Methylated mRNAs Are Enriched on Translating Ribosomes during Meiosis, and under Rapamycin Treatment
- Repression of mammalian target of Rapamycin complex 1 inhibits intestinal regeneration in acute inflammatory bowel disease models
- Epithelial to mesenchymal transition is associated with Rapamycin resistance
- Anti-breast cancer potential of quercetin via the Akt/AMPK/mammalian target of Rapamycin (mTOR) signaling cascade
- Metabolic consequences of long-term Rapamycin exposure on common marmoset monkeys (Callithrix jacchus)
- Rapamycin loaded magnetic Fe3O4/carboxymethylchitosan nanoparticles as tumor-targeted drug delivery system: synthesis and in vitro characterization
- Topical Rapamycin combined with pulsed dye laser in the treatment of capillary vascular malformations in Sturge-Weber syndrome: phase II, randomized, double-blind …
- Downregulation of cancer stem cell properties via mTOR signaling pathway inhibition by Rapamycin in nasopharyngeal carcinoma
- Effect of low-dose Rapamycin on senescence markers and physical functioning in older adults with coronary artery disease: results of a pilot study
- In vitro and in vivo sustained zero-order delivery of Rapamycin (sirolimus) from a biodegradable intraocular device
- Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A
- Rapamycin/DiR loaded lipid-polyaniline nanoparticles for dual-modal imaging guided enhanced photothermal and antiangiogenic combination therapy
- Rapamycin protects against apoptotic neuronal death and improves neurologic function after traumatic brain injury in mice via modulation of the mTOR-p53-Bax axis
- Imbalanced mechanistic target of Rapamycin C1 and C2 activity in the cerebellum of Angelman syndrome mice impairs motor function
- Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy
- Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and …
- The role of amino acid-induced mammalian target of Rapamycin complex 1 (mTORC1) signaling in insulin resistance
- Olive oil‐derived oleocanthal as potent inhibitor of mammalian target of Rapamycin: biological evaluation and molecular modeling studies
- Adaptations to chronic Rapamycin in mice
- Optimal dietary alpha‐linolenic acid/linoleic acid ratio improved digestive and absorptive capacities and target of Rapamycin gene expression of juvenile grass carp (C …
- The mammalian target of Rapamycin modulates the immunoproteasome system in the heart
- Methylglyoxal activates the target of Rapamycin complex 2-protein kinase C signaling pathway in Saccharomyces cerevisiae
- Inorganic polyphosphate elicits pro‐inflammatory responses through activation of the mammalian target of Rapamycin complexes 1 and 2 in vascular endothelial cells
- inhibition of regulatory-associated protein of mechanistic target of Rapamycin prevents hyperoxia-induced lung injury by enhancing autophagy and reducing apoptosis …
- Mammalian target of Rapamycin and tuberous sclerosis complex
- Rapatar, a nanoformulation of Rapamycin, decreases chemically-induced benign prostate hyperplasia in rats
- … reduces renal damage in ischemia/reperfusion injury: Unraveling antiapoptotic mechanisms and regulation of phosphorylated mammalian target of Rapamycin
- Baicalein triggers autophagy and inhibits the protein kinase B/mammalian target of Rapamycin pathway in hepatocellular carcinoma HepG2 cells
- Rapamycin-induced oligomer formation system of FRB–FKBP fusion proteins
- Port wine stain treated with a combination of pulsed dye laser and topical Rapamycin ointment
- SOX9-regulated cell plasticity in colorectal metastasis is attenuated by Rapamycin
- Rapamycin-resistant mTOR activity is required for sensory axon regeneration induced by a conditioning lesion
- Rapamycin reverses the senescent phenotype and improves immuno-regulation of mesenchymal stem cells from MRL/lpr mice and systemic lupus …
- inhibition of mTOR pathway by Rapamycin reduces brain damage in rats subjected to transient forebrain ischemia
- … of autophagic flux against xenoestrogen bisphenol-A-induced hippocampal neurodegeneration via AMP kinase (AMPK)/mammalian target of Rapamycin …
- Surface engineering of porous silicon microparticles for intravitreal sustained delivery of Rapamycin
- Differential effects of calcineurin and mammalian target of Rapamycin inhibitors on alloreactive Th1, Th17, and regulatory T cells
- Rapidly progressive hypertrophic cardiomyopathy in an infant with Noonan syndrome with multiple lentigines: palliative treatment with a Rapamycin analog
- Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of Rapamycin via selectively inhibiting mTORC1 in mice
- Apoptotic effects of high-dose Rapamycin occur in S-phase of the cell cycle
- Mechanistic target of Rapamycin complex 1 (mTORC1) and mTORC2 as key signaling intermediates in mesenchymal cell activation
- Rapamycin-induced autophagy activity promotes bone fracture healing in rats
- AKT inhibition overcomes Rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis
- Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum
- Complications of mammalian target of Rapamycin inhibitor anticancer treatment among patients with tuberous sclerosis complex are common and occasionally life …
- The effect of mammalian target of Rapamycin inhibition on T helper type 17 and regulatory T cell differentiation in vitro and in vivo in kidney transplant recipients
- Leucine and mammalian target of Rapamycin–dependent activation of muscle protein synthesis in aging
- inhibition of mammalian target of Rapamycin attenuates early brain injury through modulating microglial polarization after experimental subarachnoid hemorrhage in …
- Blocking mammalian target of Rapamycin (mTOR) attenuates HIF-1α pathways engaged-vascular endothelial growth factor (VEGF) in diabetic retinopathy
- Effects of Rapamycin on cell apoptosis in MCF-7 human breast cancer cells
- Dual-modal imaging-guided theranostic nanocarriers based on indocyanine green and mTOR inhibitor Rapamycin
- Rapamycin attenuates cardiac fibrosis in experimental uremic cardiomyopathy by reducing marinobufagenin levels and inhibiting downstream pro‐fibrotic signaling
- Increased mammalian target of Rapamycin signaling contributes to the accumulation of protein oxidative damage in a mouse model of Down’s syndrome
- Transforming growth factor-β is an upstream regulator of mammalian target of Rapamycin complex 2–dependent bladder cancer cell migration and invasion
- TORC1 inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich’s Ataxia
- Effects of Rapamycin against paraquat-induced pulmonary fibrosis in mice
- The Rapamycin-sensitive complex of mammalian target of Rapamycin is essential to maintain male fertility
- Best: a randomized phase ii study of vascular endothelial growth factor, RAF kinase, and mammalian target of Rapamycin combination targeted therapy with …
- Drug-related pneumonitis during mammalian target of Rapamycin inhibitor therapy: radiographic pattern-based approach in Waldenström macroglobulinemia …
- Drug-related pneumonitis during mammalian target of Rapamycin inhibitor therapy in patients with neuroendocrine tumors: a radiographic pattern-based …
- … regulates the apoptosis of bone marrow‐derived mesenchymal stem cells under hypoxic condition via AMP‐activated protein kinase/mammalian target of Rapamycin …
- Fishmeal replacement by mixed plant proteins and maggot meal on growth performance, target of Rapamycin signalling and metabolism in juvenile turbot (S …
- Quercetin inhibits fibroblast activation and kidney fibrosis involving the suppression of mammalian target of Rapamycin and β-catenin signaling
- Rapamycin loaded solid lipid nanoparticles as a new tool to deliver mTOR inhibitors: formulation and in vitro characterization
- Signaling through the phosphatidylinositol 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) axis is responsible for aerobic glycolysis mediated by …
- Mammalian target of Rapamycin mediates kidney injury molecule 1-dependent tubule injury in a surrogate model
- A phase Ib study of BEZ235, a dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mammalian target of Rapamycin (mTOR), in patients with advanced …
- Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver
- Blood–brain barrier leakage after status epilepticus in Rapamycin‐treated rats II: Potential mechanisms
- Topical use of mammalian target of Rapamycin (mTOR) inhibitors in tuberous sclerosis complex—a comprehensive review of the literature
- REDV/Rapamycin-loaded polymer combinations as a coordinated strategy to enhance endothelial cells selectivity for a stent system
- On the discovery of TOR as the target of Rapamycin
- Hepatitis B virus pre-S2 mutant induces aerobic glycolysis through mammalian target of Rapamycin signal cascade
- Phase II study of dual phosphoinositol‐3‐kinase (PI 3K) and mammalian target of Rapamycin (mTOR) inhibitor BEZ 235 in patients with locally advanced or metastatic …
- Rapamycin inhibits prostate cancer cell growth through cyclin D1 and enhances the cytotoxic efficacy of cisplatin
- mTORC1 inhibitor Rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling
- Effect of dietary glutamine on growth performance, non-specific immunity, expression of cytokine genes, phosphorylation of target of Rapamycin (TOR), and anti …
- Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice
- Formulation development and toxicity assessment of triacetin mediated nanoemulsions as novel delivery systems for Rapamycin
- Comparative metabolic profiling reveals the key role of amino acids metabolism in the Rapamycin overproduction by Streptomyces hygroscopicus
- Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish
- Glycine Regulates Protein Turnover by Activating Protein Kinase B/Mammalian Target of Rapamycin and by Inhibiting MuRF1 and Atrogin-1 Gene Expression in …
- Rapamycin inhibition of mTOR reduces levels of the Na+/H+ exchanger 3 in intestines of mice and humans, leading to diarrhea
- Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down’s syndrome
- Discovery of mammalian target of Rapamycin (mTOR) kinase inhibitor CC-223
- Conophylline protects cells in cellular models of neurodegenerative diseases by inducing mammalian target of Rapamycin (mTOR)-independent autophagy
- Pharmaceutical inhibition of mTOR in the common marmoset: effect of Rapamycin on regulators of proteostasis in a non-human primate
- Rapamycin suppresses tumor growth and alters the metabolic phenotype in T-cell lymphoma
- The immunosuppressive drug–Rapamycin–electroanalytical sensing using boron-doped diamond electrode
- A NIR fluorescent probe: imaging endogenous hydrogen peroxide during an autophagy process induced by Rapamycin
- Rapamycin inhibits lipopolysaccharide-induced neuroinflammation in vitro and in vivo
- Targeting the mammalian target of Rapamycin in lung cancer
- Mammalian target of Rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger
- Leucine does not affect mechanistic target of Rapamycin complex 1 assembly but is required for maximal ribosomal protein s6 kinase 1 activity in human skeletal …
- Sex-specific Tradeoffs With Growth and Fitness Following Life-span Extension by Rapamycin in an Outcrossing Nematode, Caenorhabditis remanei
- Rapamycin attenuates age-associated changes in tibialis anterior tendon viscoelastic properties
- Effects of Rapamycin on cerebral oxygen supply and consumption during reperfusion after cerebral ischemia
- Huaier aqueous extract sensitizes cells to Rapamycin and cisplatin through activating mTOR signaling
- Rapamycin and CTLA4Ig synergize to induce stable mixed chimerism without the need for CD40 blockade
- Target of Rapamycin activation predicts lifespan in fruit flies
- Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons
- Unleashing Rapamycin in fibrosis
- Metformin attenuates graft-versus-host disease via restricting mammalian target of Rapamycin/signal transducer and activator of transcription 3 and promoting …
- Mechanistic target of Rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC
- Prevention of irradiation-induced salivary hypofunction by Rapamycin in swine parotid glands
- Muscle wasting in fasting requires activation of NF-κB and inhibition of AKT/mechanistic target of Rapamycin (mTOR) by the protein acetylase, GCN5
- Postdepletion lymphocyte reconstitution during belatacept and Rapamycin treatment in kidney transplant recipients
- Prevention of carcinogen and inflammation-induced dermal cancer by oral Rapamycin includes reducing genetic damage
- Placenta growth factor induces invasion and activates p70 during Rapamycin treatment in trophoblast cells
- Effects of dietary leucine supplementation on the gene expression of mammalian target of Rapamycin signaling pathway and intestinal development of broilers
- Rapamycin inhibits human laryngotracheal stenosis–derived fibroblast proliferation, metabolism, and function in vitro
- Perspective: the potential role of essential amino acids and the mechanistic target of Rapamycin complex 1 (mTORC1) pathway in the pathogenesis of child stunting
- Successful topical Rapamycin treatment for facial angiofibromata in two children
- Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
- Rapamycin enhances the anti-cancer effect of dasatinib by suppressing Src/PI3K/mTOR pathway in NSCLC cells
- Soy-dairy protein blend or whey protein isolate ingestion induces similar postexercise muscle mechanistic target of Rapamycin complex 1 signaling and protein …
- Rapamycin attenuates mouse liver ischemia and reperfusion injury by inhibiting endoplasmic reticulum stress
- Up‐regulation of the mammalian target of Rapamycin complex 1 subunit raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns …
- Synergistic antitumor activity of the combination of salubrinal and Rapamycin against human cholangiocarcinoma cells
- Effect of mammalian target of Rapamycin inhibitors on cytomegalovirus infection in kidney transplant recipients receiving polyclonal antilymphocyte globulins: a …
- Rapamycin impairs endothelial cell function in human internal thoracic arteries
- Addition of Rapamycin and hydroxychloroquine to metronomic chemotherapy as a second line treatment results in high salvage rates for refractory metastatic …
- Combinatorial antitumor effect of Rapamycin and β-elemene in follicular thyroid cancer cells
- Mammalian target of Rapamycin: a target for (lung) diseases and aging
- Proximity-directed labeling reveals a new Rapamycin-induced heterodimer of FKBP25 and FRB in live cells
- Development of a model describing regulation of casein synthesis by the mammalian target of Rapamycin (mTOR) signaling pathway in response to insulin …
- Rapamycin ameliorates IgA nephropathy via cell cycle-dependent mechanisms
- … growth factor β1-induced apoptosis in podocytes via the extracellular signal-regulated kinase-mammalian target of Rapamycin complex 1-NADPH oxidase 4 …
- Valacyclovir combined with artesunate or Rapamycin improves the outcome of herpes simplex virus encephalitis in mice compared to antiviral therapy alone
- Differential phosphorylation of a regulatory subunit of protein kinase CK2 by target of Rapamycin complex 1 signaling and the Cdc-like kinase Kns1
- Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance
- Rapamycin and its analogues (rapalogs) for Tuberous Sclerosis Complex-associated tumors: a systematic review on non-randomized studies using meta …
- Phase I study of apitolisib (GDC-0980), dual phosphatidylinositol-3-kinase and mammalian target of Rapamycin kinase inhibitor, in patients with advanced solid tumors
- Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of Rapamycin signaling pathway in human bladder cancer …
- Optimization of adipose tissue-derived mesenchymal stem cells by Rapamycin in a murine model of acute graft-versus-host disease
- Blocking mammalian target of Rapamycin alleviates bone cancer pain and morphine tolerance via µ‐opioid receptor
- The effect of Rapamycin on biodiesel-producing protist Euglena gracilis
- Roles of mechanistic target of Rapamycin and transforming growth factor-β signaling in the molting gland (Y-organ) of the blackback land crab, Gecarcinus lateralis
- Traumatic brain injury stimulates neural stem cell proliferation via mammalian target of Rapamycin signaling pathway activation
- Blocking mammalian target of Rapamycin (mTOR) improves neuropathic pain evoked by spinal cord injury
- Caloric restriction promotes the reserve of follicle pool in adult female rats by inhibiting the activation of mammalian target of Rapamycin signaling
- Rapamycin inhibits oxidized low density lipoprotein uptake in human umbilical vein endothelial cells via mTOR/NF-κB/LOX-1 pathway
- The anti-diabetic drug metformin inhibits vascular endothelial growth factor expression via the mammalian target of Rapamycin complex 1/hypoxia-inducible factor-1α …
- The transcription factor p8 regulates autophagy in response to palmitic acid stress via a mammalian target of Rapamycin (mTOR)-independent signaling …
- Ubiquilin-mediated small molecule inhibition of mammalian target of Rapamycin complex 1 (mTORC1) signaling
- Combination therapy using IL-2/IL-2 monoclonal antibody complexes, Rapamycin, and islet autoantigen peptides increases regulatory T cell frequency and protects …
- Randomized open-label phase II trial of apitolisib (GDC-0980), a novel inhibitor of the PI3K/mammalian target of Rapamycin pathway, versus everolimus in …
- Chronic Rapamycin treatment on the nutrient utilization and metabolism of juvenile turbot (Psetta maxima)
- Expression of mammalian target of Rapamycin and downstream targets in normal and gestational diabetic human term placenta
- Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival
- Rapamycin protects from type-I peritoneal membrane failure inhibiting the angiogenesis, lymphangiogenesis, and Endo-MT
- Regulation of the target of Rapamycin and other phosphatidylinositol 3-kinase-related kinases by membrane targeting
- Combination of an anti-EGFRvIII antibody CH12 with Rapamycin synergistically inhibits the growth of EGFRvIII+ PTEN− glioblastoma in vivo
- Mammalian target of Rapamycin inhibitors and life-threatening conditions in tuberous sclerosis complex
- Characterization of negative regulatory genes for the biosynthesis of Rapamycin in Streptomyces Rapamycinicus and its application for improved production
- The pivotal role of mammalian target of Rapamycin inhibition in the treatment of patients with neuroendocrine tumors
- Rapamycin increases fetal hemoglobin and ameliorates the nociception phenotype in sickle cell mice
- Mammalian target of Rapamycin (mTOR) complex 2 regulates filamin A‐dependent focal adhesion dynamics and cell migration
- Brain-expressed X-linked 2 is pivotal for hyperactive mechanistic target of Rapamycin (mTOR)-mediated tumorigenesis
- The effect of different dosing schedules of intravitreal sirolimus, a mammalian target of Rapamycin (mTOR) inhibitor, in the treatment of non-infectious uveitis …
- Wogonin increases β-amyloid clearance and inhibits tau phosphorylation via inhibition of mammalian target of Rapamycin: potential drug to treat Alzheimer’s disease
- Rapamycin increases length and mechanosensory function of primary cilia in renal epithelial and vascular endothelial cells
- Analysis of proteins that rapidly change upon mechanistic/mammalian target of Rapamycin complex 1 (mTORC1) repression identifies Parkinson protein 7 …
- Characterization of the Nocardiopsin Biosynthetic Gene Cluster Reveals Similarities to and Differences from the Rapamycin and FK‐506 Pathways
- Rapamycin, a specific inhibitor of the target of Rapamycin complex 1, disrupts intestinal barrier integrity in broiler chicks
- The mechanism of Rapamycin in the intervention of paraquat-induced acute lung injury in rats
- Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+ CD25+ Foxp3 regulatory T cells
- Rapamycin influences the efficiency of in vitro fertilization and development in the mouse: a role for autophagic activation
- Profiling of the fetal and adult rat liver transcriptome and translatome reveals discordant regulation by the mechanistic target of Rapamycin (mTOR)
- Mechanistic target of Rapamycin complex 1/S6 kinase 1 signals influence T cell activation independently of ribosomal protein S6 phosphorylation
- Pharmacodynamic monitoring of mammalian target of Rapamycin inhibition by phosphoflow cytometric determination of p70S6 kinase activity
- Hyperglycemia and phosphatidylinositol 3-kinase/protein kinase B/mammalian target of Rapamycin (PI3K/AKT/mTOR) inhibitors in phase I trials: incidence …
- Rapamycin reverses paraquat-induced acute lung injury in a rat model through inhibition of NFκB activation
- Primary intestinal lymphangiectasia treated with Rapamycin in a child with tuberous sclerosis complex (TSC)
- Interferon γ (IFNγ) signaling via mechanistic target of Rapamycin complex 2 (mTORC2) and regulatory effects in the generation of type II interferon biological …
- Mammalian target of Rapamycin signaling pathway changes with intestinal epithelial cells renewal along crypt-villus axis
- Efficacy of Rapamycin as inducer of Hb F in primary erythroid cultures from sickle cell disease and β-thalassemia patients
- A central role for the mammalian target of Rapamycin in LPS-induced anorexia in mice
- Intrathecal Rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain
- Phosphorylation of ribosomal protein S6 mediates mammalian target of Rapamycin complex 1–induced parathyroid cell proliferation in secondary hyperparathyroidism
- Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinase
- Amino acid sensing and activation of mechanistic target of Rapamycin complex 1: implications for skeletal muscle
- Rapamycin‐induced autophagy sensitizes A549 cells to radiation associated with DNA damage repair inhibition
- Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of Rapamycin complex 1 in mice
- Rapamycin protects cardiomyocytes against anoxia/reoxygenation injury by inducing autophagy through the PI3k/Akt pathway
- Paradoxical effect of Rapamycin on inflammatory stress-induced insulin resistance in vitro and in vivo
- Effect of Rapamycin on endometriosis in mice
- Mammalian target of Rapamycin (mTOR) tagging promotes dendritic branch variability through the capture of Ca2+/calmodulin-dependent protein kinase II α …
- Combined treatment of Nimotuzumab and Rapamycin is effective against temozolomide-resistant human gliomas regardless of the EGFR mutation status
- Effects of combining Rapamycin and resveratrol on apoptosis and growth of TSC2-deficient xenograft tumors
- Particulate matter 2.5 induces autophagy via inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin kinase signaling pathway in …
- Th1, Th2 and Th17 cytokine profile in patients with multiple sclerosis following treatment with Rapamycin
- Mechanistic target of Rapamycin (mTOR) inhibition synergizes with reduced internal ribosome entry site (IRES)-mediated translation of cyclin D1 and c-MYC …
- A phase I–II study on the combination of Rapamycin and short course radiotherapy in rectal cancer
- Mechanical stretch activates mammalian target of Rapamycin and AMP-activated protein kinase pathways in skeletal muscle cells
- Safety considerations of mammalian target of Rapamycin inhibitors in tuberous sclerosis complex and renal transplantation
- Self-assembled micelles of amphiphilic PEGylated Rapamycin for loading paclitaxel and resisting multidrug resistant cancer cells
- Defining the domain arrangement of the mammalian target of Rapamycin complex component Rictor protein
- Target of Rapamycin signaling mediates vacuolar fission caused by endoplasmic reticulum stress in Saccharomyces cerevisiae
- Ciliary transport regulates PDGF-AA/αα signaling via elevated mammalian target of Rapamycin signaling and diminished PP2A activity
- Anorexic response to Rapamycin does not appear to involve a central mechanism
- Rapamycin versus intermittent feeding: dissociable effects on physiological and behavioral outcomes when initiated early and late in life
- Conversion from calcineurin to mammalian target of Rapamycin inhibitors in liver transplantation: a meta-analysis of randomized controlled trials
- Rapamycin-Mediated mTOR inhibition Reverses Drug Resistance to Adriamycin in Colon Cancer Cells.
- Rapamycin-loaded solid lipid nanoparticles: Morphology and impact of the drug loading on the phase transition between lipid polymorphs
- 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of Rapamycin in human cancer cells
- Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of Rapamycin
- Rapamycin protects neurons from brain contusion‑induced inflammatory reaction via modulation of microglial activation
- Rapamycin inhibited the function of lung CSCs via SOX2
- iPSC-MSCs combined with low-dose Rapamycin induced islet allograft tolerance through suppressing Th1 and enhancing regulatory T-cell differentiation
- Dual PI3K/mTOR inhibitor, XL765 (SAR245409), shows superior effects to sole PI3K [XL147 (SAR245408)] or mTOR [Rapamycin] inhibition in prostate cancer cell …
- Encapsulation and controlled release of Rapamycin from polycaprolactone nanoparticles prepared by membrane micromixing combined with antisolvent precipitation
- Active mechanistic target of Rapamycin plays an ancillary rather than essential role in zebrafish CNS axon regeneration
- First-line and sequential use of pazopanib followed by mammalian target of Rapamycin inhibitor therapy among patients with advanced renal cell carcinoma in a US …
- Mammalian target of Rapamycin inhibitor RAD001 sensitizes endometrial cancer cells to paclitaxel-induced apoptosis via the induction of autophagy
- Mechanistic target of Rapamycin complex 1 is an essential mediator of metabolic and mitogenic effects of fibroblast growth factor 19 in hepatoma cells
- Rapamycin/GABA combination treatment ameliorates diabetes in NOD mice
- Isoflurane promotes non-small cell lung cancer malignancy by activating the Akt-mammalian target of Rapamycin (mTOR) signaling pathway
- Synergistic effect of JQ 1 and Rapamycin for treatment of human osteosarcoma
- Local application of Rapamycin reduces epidural fibrosis after laminectomy via inhibiting fibroblast proliferation and prompting apoptosis
- SR4 uncouples mitochondrial oxidative phosphorylation, modulates AMP-dependent kinase (AMPK)-mammalian target of Rapamycin (mTOR) signaling, and …
- Rapamycin, a mTOR inhibitor, induced growth inhibition in retinoblastoma Y79 cell via down-regulation of Bmi-1
- Four-week Rapamycin treatment improves muscular dystrophy in a fukutin-deficient mouse model of dystroglycanopathy
- Rapamycin normalizes serum leptin by alleviating obesity and reducing leptin synthesis in aged rats
- L-arginine upregulates the gene expression of target of Rapamycin signaling pathway and stimulates protein synthesis in chicken intestinal epithelial cells
- Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following Rapamycin treatment in a mouse model of temporal lobe epilepsy
- Rapamycin treatment during in vitro maturation of oocytes improves embryonic development after parthenogenesis and somatic cell nuclear transfer in pigs
- Dual phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitor is an effective radiosensitizer for colorectal cancer
- Intrathecal administration of Rapamycin inhibits the phosphorylation of DRG Nav1. 8 and attenuates STZ-induced painful diabetic neuropathy in rats
- Chemical genomics approach to identify genes associated with sensitivity to Rapamycin in the fission yeast Schizosaccharomyces pombe
- Yes‐associated protein 1 and transcriptional coactivator with PDZ‐binding motif activate the mammalian target of Rapamycin complex 1 pathway by regulating amino …
- Validation of mammalian target of Rapamycin biomarker panel in patients with clear cell renal cell carcinoma
- The rodent malaria liver stage survives in the Rapamycin-induced autophagosome of infected Hepa1–6 cells
- inhibition of MDM2 Re-sensitizes Rapamycin resistant renal cancer cells via the activation of p53
- Expression of zTOR-associated microRNAs in zebrafish embryo treated with Rapamycin
- Glucocorticoids inhibited hypothalamic target of Rapamycin in high fat diet-fed chicks
- Diosmetin inhibits cell proliferation and induces apoptosis by regulating autophagy via the mammalian target of Rapamycin pathway in hepatocellular …
- Outcome of Rapamycin therapy for post-transplant-lymphoproliferative disorder after kidney transplantation: case series
- Therapeutic targeting of the IL-6 trans-signaling/mechanistic target of Rapamycin complex 1 axis in pulmonary emphysema
- Rapamycin prevents bronchiolitis obliterans through increasing infiltration of regulatory B cells in a murine tracheal transplantation model
- … of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of Rapamycin complex 1 (mTORC1) …
- Suppression of the proliferation of hypoxia‐Induced retinal pigment epithelial cell by Rapamycin through the/mTOR/HIF‐1α/VEGF/signaling
- Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 against osteosarcoma
- Preparation and preclinical evaluation of inhalable particles containing Rapamycin and anti-tuberculosis agents for induction of autophagy
- Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate Rapamycin treatment
- Efficacy and safety of a mammalian target of Rapamycin inhibitor in pediatric patients with tuberous sclerosis complex: A systematic review and meta-analysis
- Mammalian target of Rapamycin overexpression antagonizes chronic hypoxia-triggered pulmonary arterial hypertension via the autophagic pathway
- Mammalian target of Rapamycin complex 2 (mTORC2) regulates LPS‐induced expression of IL‐12 and IL‐23 in human dendritic cells
- Comparative analysis of Rapamycin biosynthesis clusters between Actinoplanes sp. N902-109 and Streptomyces hygroscopicus ATCC29253
- … acid broadly suppresses cancer metabolism and synergistically induces strong anticancer activity in combination with etoposide, Rapamycin and UCN-01
- inhibition of Akt enhances the chemopreventive effects of topical Rapamycin in mouse skin
- Comparative analysis of protocols to induce human CD4+ Foxp3+ regulatory T cells by combinations of IL-2, TGF-beta, retinoic acid, Rapamycin and butyrate
- Role of the mammalian target of Rapamycin pathway and Rapamycin in lentiviral vector gene transduction of hematopoietic stem cells
- Dysregulation of anergy‐related factors involved in regulatory T cells defects in Systemic Lupus Erythematosus patients: Rapamycin and Vitamin D efficacy in …
- Profibrotic up‐regulation of glucose transporter 1 by TGF‐β involves activation of MEK and mammalian target of Rapamycin complex 2 pathways
- Screening of mammalian target of Rapamycin inhibitors in natural product extracts by capillary electrophoresis in combination with high performance liquid …
- Mammalian target of Rapamycin complex (mTOR) pathway modulates blood-testis barrier (BTB) function through F-actin organization and gap junction
- Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B …
- Rapamycin, an mTOR inhibitor, induced apoptosis via independent mitochondrial and death receptor pathway in retinoblastoma Y79 cell
- Peroxisome proliferator‑activated receptor‑γ agonist inhibits the mammalian target of Rapamycin signaling pathway and has a protective effect in a rat model of …
- Rapamycin interferes with postdepletion regulatory T cell homeostasis and enhances DSA formation corrected by CTLA4‐Ig
- Rapamycin regulates the proliferation of Huh7, a hepatocellular carcinoma cell line, by up-regulating p53 expression
- … activating polypeptide II contributes to the inhibition of malignant biological behaviors by the combination of EMAP II with Rapamycin in human glioblastoma
- Nephrin contributes to insulin secretion and affects mammalian target of Rapamycin signaling independently of insulin receptor
- Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production
- Renal tumours in a Tsc2+/− mouse model do not show feedback inhibition of Akt and are effectively prevented by Rapamycin
- 17ss-Estradiol regulates mTORC2 sensitivity to Rapamycin in adaptive cardiac remodeling
- Rapamycin and fructose-1, 6-bisphosphate reduce the HEPG2 cell proliferation via increase of free radicals and apoptosis
- The mechanistic target of Rapamycin (mTOR) pathway and S6 Kinase mediate diazoxide preconditioning in primary rat cortical neurons
- Different in vitro proliferation and cytokine‐production inhibition of memory T‐cell subsets after calcineurin and mammalian target of Rapamycin inhibitors treatment
- Functional proteomics identifies acinus L as a direct insulin-and amino acid-dependent mammalian target of Rapamycin complex 1 (mTORC1) substrate
- Phosphorylated mammalian target of Rapamycin p-mTOR is a favorable prognostic factor than mTOR in gastric cancer
- Formaldehyde exposure inhibits the expression of mammalian target of Rapamycin in rat testis
- Rapamycin attenuates splenomegaly in both intrahepatic and prehepatic portal hypertensive rats by blocking mTOR signaling pathway
- Transforming somatic mutations of mammalian target of Rapamycin kinase in human cancer
- Significance of mammalian target of Rapamycin in patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy …
- NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of Rapamycin-induced aerobic glycolysis and tumor growth
- Local in vitro delivery of Rapamycin from electrospun PEO/PDLLA nanofibers for glioblastoma treatment
- Target of Rapamycin Complex 2 regulates cell growth via Myc in Drosophila
- Expression and clinical significance of mammalian target of Rapamycin/P70 ribosomal protein S6 kinase signaling pathway in human colorectal carcinoma …
- Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways
- Differential effects of Rapamycin treatment on tonic and phasic GABAergic inhibition in dentate granule cells after focal brain injury in mice
- The effect of Rapamycin on oxidative stress in MCF-7 and MDA MB-231 human breast cancer cell lines
- Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium
- Discovery of leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of Rapamycin complex 1 (mTORC1) inhibitors
- … and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimer’s disease via mammalian target of Rapamycin-dependent and-independent …
- Targeting Rapamycin to podocytes using a vascular cell adhesion molecule-1 (VCAM-1)-harnessed SAINT-based lipid carrier system
- Rapamycin promotes the autophagic degradation of oxidized low-density lipoprotein in human umbilical vein endothelial cells
- Effects of topically applied Rapamycin and mycophenolic acid on TNCB-induced atopic dermatitis-like skin lesions in NC/Nga mice
- Rapamycin ameliorates brain metabolites alterations after transient focal ischemia in rats
- Rapamycin promotes mouse 4T1 tumor metastasis that can be reversed by a dendritic cell-based vaccine
- Angiographic and volumetric effects of mammalian target of Rapamycin inhibitors on angiomyolipomas in tuberous sclerosis
- Effects of metformin and a mammalian target of Rapamycin (mTOR) ATP-competitive inhibitor on targeted metabolomics in pancreatic cancer cell line
- Rapamycin safeguards lymphocytes from DNA damage accumulation in vivo
- The mechanism of synergistic effects of arsenic trioxide and Rapamycin in acute myeloid leukemia cell lines lacking typical t (15; 17) translocation
- Anti-tumor effect of the mammalian target of Rapamycin inhibitor everolimus in oral squamous cell carcinoma
- Functionally conserved effects of Rapamycin exposure on zebrafish
- Neuroendocrine tumors resistant to mammalian target of Rapamycin inhibitors: A difficult conversion from biology to the clinic
- Fucoidan inhibits the migration and proliferation of HT-29 human colon cancer cells via the phosphoinositide-3 kinase/Akt/mechanistic target of Rapamycin …
- Preventive effects of Rapamycin on inflammation and capillary degeneration in a rat model of NMDA-induced retinal injury
- Profiling the role of mammalian target of Rapamycin in the vascular smooth muscle metabolome in pulmonary arterial hypertension
- Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes
- Relationship between mammalian target of Rapamycin and autophagy in lipopolysaccharide-induced lung injury
- CX-5461 induces autophagy and inhibits tumor growth via mammalian target of Rapamycin-related signaling pathways in osteosarcoma
- Rapamycin protects dopaminergic neurons against rotenone-induced cell death in primary mesencephalic cell culture
- Downregulation of p70S6K enhances cell sensitivity to Rapamycin in esophageal squamous cell carcinoma
- … and pharmacodynamics of SAR245409 (voxtalisib, XL765), an orally administered phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitor: a phase 1 …
- Combined image guided monitoring the pharmacokinetics of Rapamycin loaded human serum albumin nanoparticles with a split luciferase reporter
- Celecoxib sensitizes gastric cancer to Rapamycin via inhibition of the Cbl-b-regulated PI3K/Akt pathway
- Effects of Rapamycin on reduction of peridural fibrosis: an experimental study
- Long-term alcohol-induced activation of mammalian target of Rapamycin is a key risk factor of epilepsy
- Time-dependent effects of Rapamycin on consolidation of predator stress-induced hyperarousal
- Plum polyphenols inhibit colorectal aberrant crypt foci formation in rats: potential role of the miR-143/protein kinase B/mammalian target of Rapamycin axis
- Tuberous Sclerosis Complex 1–Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch
- Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice
- … inhibition enhances colorectal cancer apoptosis induced by dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235
- Stents coated with mammalian target of Rapamycin inhibitors (mTOR) appear to be the best choice in patients with antiphospholipid syndrome and myocardial …
- Susceptibility of PTEN-positive metastatic tumors to small interfering RNA targeting the mammalian target of Rapamycin
- Microsphere-based Rapamycin delivery, systemic versus local administration in a rat model of renal ischemia/reperfusion injury
- … sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of Rapamycin …
- A comprehensive proteomic and phosphoproteomic analysis of yeast deletion mutants of 14‐3‐3 orthologs and associated effects of Rapamycin
- Targeting the mammalian target of Rapamycin pathway with everolimus: Implications for the management of metastatic breast cancer
- Rapamycin can restore the negative regulatory function of transforming growth factor beta 1 in high grade lymphomas
- … of long‐chain acyl‐CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of Rapamycin complex 1 activation
- Glucocorticoids retard skeletal muscle development and myoblast protein synthesis through a mechanistic target of Rapamycin (mTOR)-signaling pathway in broilers …
- … first‐line pazopanib therapy followed by vascular endothelial growth factor receptor tyrosine kinase inhibitors or mammalian target of Rapamycin inhibitors: a single …
- Evaluating the effect of 20-hydroxyecdysone (20HE) on mechanistic target of Rapamycin complex 1 (mTORC1) signaling in the skeletal muscle and liver of rats
- Mammalian target of Rapamycin inhibitor–associated stomatitis in hematopoietic stem cell transplantation patients receiving sirolimus prophylaxis for graft …
- Rapamycin (Sirolimus) alters mechanistic target of Rapamycin pathway regulation and microRNA expression in mouse meiotic spermatocytes
- Rapamycin ameliorates chitosan nanoparticle-induced developmental defects of preimplantation embryos in mice
- The Akt/mTOR/p70S6K pathway is activated in IgA nephropathy and Rapamycin may represent a viable treatment option
- Increase of microRNA-210, decrease of raptor gene expression and alteration of mammalian target of Rapamycin regulated proteins following mithramycin …
- Slow-releasing Rapamycin-coated bionic peripheral nerve scaffold promotes the regeneration of rat sciatic nerve after injury
- Differential expression of GAS 5 in Rapamycin‐induced reversion of glucocorticoid resistance
- Rapamycin targets Interleukin 6 (IL-6) expression and suppresses endothelial cell invasion stimulated by tumor cells
- Klotho upregulation by Rapamycin protects against vascular disease in CKD
- Pharmacokinetics of orally administered low-dose Rapamycin in healthy dogs
- Reduction of intraarticular adhesion of knee by local application of Rapamycin in rabbits via inhibition of fibroblast proliferation and collagen synthesis
- … and cancer stem-like cell properties via the vascular endothelial growth factor (VEGF)/phosphatidylinositol 3-kinase (PI3K)/Akt/mechanistic target of Rapamycin …
- Anticancer mammalian target of Rapamycin (mTOR) signaling pathway inhibitors: current status, challenges and future prospects in management of epilepsy
- … contributes to early oligodendrocyte progenitor proliferation by activating phosphatidylinositol 3-kinase (PI3K)/AKT and the mammalian target of Rapamycin (mTOR) …
- Curcumin attenuates Rapamycin-induced cell injury of vascular endothelial cells
- Formulation and characterization of a 0.1% Rapamycin cream for the treatment of Tuberous Sclerosis Complex-related angiofibromas
- Potential role for mammalian target of Rapamycin inhibitors as first-line therapy in hormone receptor–positive advanced breast cancer
- Mammalian target of Rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia
- inhibition of insulin-like growth factor receptor/AKT/mammalian target of Rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate …
- A treadmill exercise reactivates the signaling of the mammalian target of Rapamycin (mTOR) in the skeletal muscles of starved mice
- The pan phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary …
- … peptide-2 on the tight junction and barrier function in IPEC-J2 cells through phosphatidylinositol 3-kinase–protein kinase B–mammalian target of Rapamycin …
- Protein kinase FgSch 9 serves as a mediator of the target of Rapamycin and high osmolarity glycerol pathways and regulates multiple stress responses and secondary …
- Manganese-stimulated kisspeptin is mediated by the IGF-1/Akt/mammalian target of Rapamycin pathway in the prepubertal female rat
- Anticancer effect of Rapamycin on MCF-7 via downregulation of VEGF expression
- … -2-decenoic acid, the major lipid component of royal jelly, extends the lifespan of Caenorhabditis elegans through dietary restriction and target of Rapamycin …
- Immunohistochemical analysis of phosphorylated mammalian target of Rapamycin and its downstream signaling components in invasive breast cancer
- … factor induces autophagy to resist hypoxia/serum deprivation‑induced apoptosis via the AMP‑activated protein kinase/mammalian target of Rapamycin …
- Rapamycin impairs HPD‐induced beneficial effects on glucose homeostasis
- Effects of mammalian target of Rapamycin inhibitors on cytokine production and differentiation in keratinocytes
- Factors influencing the central nervous system distribution of a novel phosphoinositide 3-kinase/mammalian target of Rapamycin inhibitor GSK2126458: implications …
- Regulation of cardiac miR‐208a, an inducer of obesity, by Rapamycin and nebivolol
- A pilot, single arm, prospective trial using neoadjuvant Rapamycin prior to definitive therapy in head and neck squamous cell carcinoma.
- inhibition of mTOR by Rapamycin results in auditory hair cell damage and decreased spiral ganglion neuron outgrowth and neurite formation in vitro
- Target of Rapamycin (TOR) in Fenneropenaeus chinensis: cDNA cloning, characterization, tissue expression and response to amino acids
- Targeted inhibition of phosphoinositide 3-kinase/mammalian target of Rapamycin sensitizes pancreatic cancer cells to doxorubicin without exacerbating cardiac toxicity
- Rapamycin inhibits the proliferation of SW1990 pancreatic cancer cell
- Rapamycin restores p14, p15 and p57 expression and inhibits the mTOR/p70S6K pathway in acute lymphoblastic leukemia cells
- Rapamycin release study of porous poly (L-lactic acid) scaffolds, prepared via coaxial electrospinning
- Activation of autophagy by Rapamycin does not protect oligodendrocytes against protein aggregate formation and cell death induced by proteasomal inhibition
- … inhibition of tumor necrosis factor-alpha-stimulated pro-inflammatory cytokine expression in HaCaT cells by a combination of Rapamycin and mycophenolic acid
- Systemic Rapamycin to prevent in-stent stenosis in peripheral pulmonary arterial disease: early clinical experience
- Characterization of the Rapamycin-inducible EBV LMP1 activation system
- … antitumoral properties and renal-associated tissue damage induced by tacrolimus and mammalian target of Rapamycin inhibitors in hepatocarcinoma: in vitro …
- Mammalian Target of Rapamycin Inhibitors and Nephrotoxicity: Fact or Fiction.
- HIF-1α and Rapamycin act as gerosuppressant in multiple myeloma cells upon genotoxic stress
- inhibition of the mammalian target of Rapamycin complex 1 signaling pathway reduces itch behaviour in mice
- Rapamycin ameliorates the CTLA4‐Ig–mediated defect in CD8+ T cell immunity during gammaherpesvirus infection
- inhibition of mammalian target of Rapamycin activation in the rostral anterior cingulate cortex attenuates pain-related aversion in rats
- … Factor Beta 1 Induced Myofibroblast Differentiation via the Phosphorylated-Phosphatidylinositol 3-Kinase Mammalian Target of Rapamycin Signal Pathways in Nasal …
- Aschantin targeting on the kinase domain of mammalian target of Rapamycin suppresses epidermal growth factor-induced neoplastic cell transformation
- Up-regulation of the excitatory amino acid transporters EAAT1 and EAAT2 by mammalian target of Rapamycin
- Stereoselective synthesis of Rapamycin fragment to build a macrocyclic toolbox
- Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats
- Rapamycin up-regulates triglycerides in hepatocytes by down-regulating Prox1
- The regulatory T cell effector molecule fibrinogen‐like protein 2 is necessary for the development of Rapamycin‐induced tolerance to fully MHC‐mismatched murine …
- Importance of EEG in validating the chronic effects of drugs: Suggestions from animal models of epilepsy treated with Rapamycin
- The effect of mammalian target of Rapamycin versus calcineurin inhibitor–based immunosuppression on measured versus estimated glomerular filtration rate after …
- inhibition of wild‐type p53‐induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of Rapamycin
- MicroRNA-761 inhibits Angiotensin II-induced vascular smooth muscle cell proliferation and migration by targeting mammalian target of Rapamycin
- Targeted therapy of colorectal neoplasia with Rapamycin in peptide-labeled pegylated octadecyl lithocholate micelles
- Rapamycin causes growth arrest and inhibition of invasion in human chondrosarcoma cells
- Role of mechanistic target of Rapamycin (mTOR) in renal function and ischaemia–reperfusion induced kidney injury
- Clinically-relevant cyclosporin and Rapamycin concentrations enhance regulatory T cell function to a similar extent but with different mechanisms: an in-vitro study in …
- Effects of slow-release urea and rumen-protected methionine and histidine on mammalian target of Rapamycin (mTOR) signaling and ubiquitin proteasome …
- Rapamycin‐induced hypoxia inducible factor 2A is essential for chondrogenic differentiation of amniotic fluid stem cells
- Tumor Progression Locus 2 (Tpl2) activates the mammalian target of Rapamycin (mTOR) pathway, inhibits forkhead box P3 (FoxP3) Expression, and limits …
- Pubertal development in pediatric kidney transplant patients receiving mammalian target of Rapamycin inhibitors or conventional immunosuppression
- Rapamycin as novel treatment for refractory-to-standard-care slow-flow vascular malformations
- Contribution of mammalian target of Rapamycin in the pathophysiology of cirrhotic cardiomyopathy
- Possible activation by the green tea amino acid theanine of mammalian target of Rapamycin signaling in undifferentiated neural progenitor cells in vitro
- inhibition of mammalian target of Rapamycin complex 1 (mTORC1) downregulates ELOVL1 gene expression and fatty acid synthesis in goat fetal fibroblasts
- … and hyperlipidemia in patients with advanced cancer receiving combination treatment with the mammalian target of Rapamycin inhibitor temsirolimus and …
- Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells
- Lack of benefits of mammalian target of Rapamycin inhibitor in patients transplanted for hepatocellular carcinoma: Is this the end of the story?
- The efficacy and safety of mammalian target of Rapamycin inhibitors ab initio after liver transplantation without corticosteroids or induction therapy
- In silico analysis of conformational changes induced by normal and mutation of macrophage infectivity potentiator catalytic residues and its interactions with Rapamycin
- … of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of Rapamycin (mTOR) and impaired …
- Synergism between the mTOR inhibitor Rapamycin and FAK down-regulation in the treatment of acute lymphoblastic leukemia
- inhibition of galectin-1 sensitizes HRAS-driven tumor growth to Rapamycin treatment
- A signal-on fluorosensor based on quench-release principle for sensitive detection of antibiotic Rapamycin
- Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with Rapamycin at high resolution
- Rapamycin inhibits expression of elongation of very-long-chain fatty acids 1 and synthesis of docosahexaenoic acid in bovine mammary epithelial cells
- Rapamycin combined with immature dendritic cells attenuates obliterative bronchiolitis in trachea allograft rats by regulating the balance of regulatory and effector T …
- An efficient method to generate gene deletion mutants of the Rapamycin-producing bacterium Streptomyces iranensis HM 35
- Are invertebrates relevant models in ageing research? Focus on the effects of Rapamycin on TOR
- Ileal neuroendocrine tumors show elevated activation of mammalian target of Rapamycin complex
- Activation of extracellular regulated kinase and mechanistic target of Rapamycin pathway in focal cortical dysplasia
- Use of mammalian target of Rapamycin inhibitors after failure of tyrosine kinase inhibitors in patients with metastatic renal cell carcinoma undergoing hemodialysis: A …
- Resveratrol Potentiates Growth Inhibitory Effects of Rapamycin in PTEN-deficient Lipoma Cells by Suppressing p70S6 Kinase Activity
- Mechanistic target of Rapamycin is activated in bovine granulosa cells after LH surge but is not essential for ovulation
- Insulin-like growth factor 1/mammalian target of Rapamycin and AMP-activated protein kinase signaling involved in the effects of metformin in the human endometrial …
- Rapamycin-associated lymphoedema in an infant with Kasabach-Merritt phenomenon
- Selective tuberous sclerosis complex 1 gene deletion in smooth muscle activates mammalian target of Rapamycin signaling and induces pulmonary hypertension
- Effect of imatinib mesylate and Rapamycin on the preformed intimal hyperplasia in rat carotid injury model
- Effect of the dual phosphatidylinositol 3‑kinase/mammalian target of Rapamycin inhibitor NVP‑BEZ235 against human Merkel cell carcinoma MKL‑1 cells
- Effects of intrathecal injection of Rapamycin on pain threshold and spinal cord glial activation in rats with neuropathic pain
- Phase 1b study of the mammalian target of Rapamycin inhibitor sirolimus in combination with nanoparticle albumin–bound paclitaxel in patients with advanced solid …
- Cell synchronization by Rapamycin improves the developmental competence of porcine SCNT embryos
- Rapamycin-conditioned dendritic cells induced immune tolerance through the regulation of Treg/Th17 cells in mice
- The regulation of autophagy in porcine blastocysts: Regulation of PARylation-mediated autophagy via mammalian target of Rapamycin complex 1 (mTORC1) signaling
- The mammalian target of Rapamycin complex 1 (mTORC1) in breast cancer: the impact of oestrogen receptor and HER2 pathways
- Combination therapy of intraperitoneal Rapamycin and convection-enhanced delivery of nanoliposomal CPT-11 in rodent orthotopic brain tumor xenografts
- Rapamycin protects against neuronal death and improves neurological function with modulation of microglia after experimental intracerebral hemorrhage in rats
- Intracrine steroid production and mammalian target of Rapamycin pathways in pulmonary lymphangioleiomyomatosis
- Torin2 potentiates anticancer effects on adult T-cell leukemia/lymphoma by inhibiting mammalian target of Rapamycin
- Role of Ragulator in the regulation of mechanistic target of Rapamycin signaling in podocytes and glomerular function
- Rapamycin enhanced the antitumor efficacy of oxaliplatin in cisplatin-resistant ovarian cancer cells A2780cis both in vitro and in vivo
- Corosolic acid enhances 5‑fluorouracil‑induced apoptosis against SNU‑620 human gastric carcinoma cells by inhibition of mammalian target of Rapamycin
- Effectiveness of inhibitor Rapamycin, saracatinib, linsitinib and JNJ-38877605 against human prostate cancer cells
- Dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor NVP-BEZ235 synergizes with chloroquine to induce apoptosis in embryonal …
- Mammalian target of Rapamycin inhibition after solid organ transplantation: can it, and does it, reduce cancer risk?
- Down‐regulation of mitogen‐activated protein kinases and nuclear factor‐κB signaling is involved in Rapamycin suppression of TLR2‐induced inflammatory response …
- PP242 suppresses bladder cancer cell proliferation and migration through deactivating the mammalian target of Rapamycin complex 2/AKT1 signaling …
- Enhanced antitumor activity of 3-bromopyruvate in combination with Rapamycin in vivo and in vitro
- Preparation and experimental research into retrievable Rapamycin-and heparin-coated vena cava filters: a pilot study
- Delayed reendothelialization with Rapamycin is rescued by the addition of nicorandil in balloon-injured rat carotid arteries
- Mammalian target of Rapamycin/p70 ribosomal S6 protein kinase signaling is altered by sevoflurane and/or surgery in aged rats
- Rapamycin attenuates palmitate-induced lipid aggregation by up-regulating sirt-1 signaling in AML12 hepatocytes
- Direct implantation of Rapamycin-eluting stents with bioresorbable drug carrier technology utilising the Svelte coronary stent-on-a-wire: the DIRECT II study
- Regulation of human trophoblast GLUT3 glucose transporter by mammalian target of Rapamycin signaling
- … of bone loss with the upregulation of survival-related genes and concomitant downregulation of Mammalian target of Rapamycin and osteoblast differentiation …
- The imidazo [1, 2-a] pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) inhibitors
- Frameshift mutations in mammalian target of Rapamycin pathway genes and their regional heterogeneity in sporadic colorectal cancers
- Synthesis of Rapamycin Derivatives Containing the Triazole Moiety Used as Potential mTOR‐Targeted Anticancer Agents
- Fatigue with vascular endothelial growth factor receptor tyrosine kinase inhibitors and mammalian target of Rapamycin inhibitors in patients with renal cell carcinoma …
- mTOR inhibition by Rapamycin increases ceramide synthesis by promoting transforming growth factor‐β1/Smad signaling in the skin
- Effects of Rapamycin treatment on pancreatic fibrosis, cellular apoptosis and oxidative stress in experimental chronic pancreatitis model
- PC-1/PrLZ confers resistance to Rapamycin in prostate cancer cells through increased 4E-BP1 stability
- In vitro interactions between target of Rapamycin kinase inhibitor and antifungal agents against Aspergillus species
- Topical mTOR (mechanistic target of Rapamycin) inhibitor therapy in facial angiofibroma
- Design, synthesis and biological evaluation of novel Rapamycin benzothiazole hybrids as mTOR targeted anti-cancer agents
- Extracellular signal–regulated kinase–mammalian target of Rapamycin signaling and forkhead-box transcription factor 3a phosphorylation are involved in …
- Cell cycle status dictates effectiveness of Rapamycin
- Recognition and management of oral mucosal injury caused by mammalian target of Rapamycin inhibitors: a case series
- The 4E-BP1/eIF4E ratio is a determinant for Rapamycin response in esophageal cancer cells
- Use of topical Rapamycin in facial angiofibromas in Indian skin type
- Blocking mammalian target of Rapamycin alleviates bladder hyperactivity and pain in rats with cystitis
- Rapamycin prevents acute dendritic injury following seizures
- Oxaliplatin-Rapamycin combination was superior to mono-drug in treatment of hepatocellular carcinoma both in vitro and in vivo.
- Rapamycin decreases the osteogenic response in aortic valve interstitial cells through the stat3 pathway
- Pathological findings of a subependymal giant cell astrocytoma following treatment with Rapamycin
- Restoration of normal cerebral oxygen consumption with Rapamycin treatment in a rat model of autism–tuberous sclerosis
- Gene expression in the liver of female, but not male mice treated with Rapamycin resembles changes observed under dietary restriction
- Protective effects of Rapamycin induced autophagy on acute kidney injury induced by sepsis
- … receptor 2 and downstream pathways of receptor tyrosine kinases involving phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin or mitogen-activated …
- 4D MRI of polycystic kidneys from Rapamycin‐treated Glis3‐deficient mice
- The mammalian target of Rapamycin signaling pathway regulates myocyte enhancer factor‐2C phosphorylation levels through integrin‐linked kinase in goat skeletal …
- Mammalian‐target of Rapamycin inhibition with temsirolimus in myelodysplastic syndromes (MDS) patients is associated with considerable toxicity: results of the …
- Rapamycin decreases irradiation-induced hematopoietic system damage
- Conversion from calcineurin inhibitors to mammalian target-of-Rapamycin inhibitors in heart transplant recipients: a meta-analysis of randomized controlled trials
- Mechanistic target of Rapamycin modulation: an emerging therapeutic approach in a wide variety of disease processes
- The dynamics of histone H2A ubiquitination in HeLa cells exposed to Rapamycin, ethanol, hydroxyurea, ER stress, heat shock and DNA damage
- Intracellular release of Rapamycin from poly (lactic acid) nanospheres modifies autophagy
- Chronic Rapamycin treatment exacerbates metabolism and does not down-regulate mTORC2/Akt signaling in diabetic mice induced by high-fat diet and streptozotocin
- A case of esophageal adenocarcinoma on long‐term Rapamycin monotherapy
- Early and delayed intervention with Rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice
- The effect of Rapamycin on TGFβ1 and MMP1 expression in a rabbit model of urethral stricture
- Effects of Rapamycin induced cellular autophagy in aging-related diseases
- Rapamycin slows down gut aging
- Rapamycin in the treatment of cardiac rhabdomyoma associated with tuberous sclerosis complex
- miR-144 regulates BCG-and Rapamycin-induced autophagy by targeting Atg4a in RAW264. 7 cells
- Joining forces: first application of a Rapamycin‐induced dimerizable Cre system for conditional null mutant analysis in Leishmania
- Additive effects of Rapamycin and aspirin on dendritic cell allostimulatory capacity
- Rapamycin-conditioned dendritic cells activated with monophosphoryl lipid-A promote allograft acceptance in vivo
- The yeast ζ‐crystallin/NADPH: quinone oxidoreductase (Zta1p) is under nutritional control by the target of Rapamycin pathway and is involved in the regulation of …
- Role of Mammalian Target of Rapamycin (mTOR) in Cardiac Homeostasis in Metabolic Disorders
- Effect of nourishing “yin” removing “fire” Chinese herbal mixture on hypothalamic mammalian target of Rapamycin expression during onset of puberty in female …
- Effect of Rapamycin (RAPA) on the growth of lung cancer and its mechanism in mice with A549
- Mammalian target of Rapamycin (mTOR) activity promotes neuronal survival in stroke with or without ischemic postconditioning
- Overexpression of TOR (target of Rapamycin) inhibits cell proliferation in Dictyostelium discoideum
- … and activator of transcription 3 (JAK2/STAT3) signaling pathway in pancreatic acinar cells in rats, while AG490 and Rapamycin inhibit their activation
- Protective effects of low-dose Rapamycin combined with valsartan on podocytes of diabetic rats
- Mammalian target of Rapamycin inhibitor monotherapy: efficacy in renal transplantation
- Activation of the mammalian target of Rapamycin in the rostral ventromedial medulla contributes to the maintenance of nerve injury-induced neuropathic pain …
- Rapamycin improves mortality following intestinal ischemia-reperfusion via the inhibition of remote lung inflammation in mice
- Effect of Rapamycin on the balance of T helper cell subsets in rats with pulmonary fibrosis
- Protective effect of silymarin against Rapamycin-induced apoptosis and proliferation inhibition in endothelial progenitor cells
- Efficacy and toxicity of mammalian target Rapamycin inhibitors in patients with metastatic renal cell carcinoma with renal insufficiency: the Korean Cancer …
- Efficacy and mechanism of local delivery of Rapamycin and Rapamycin-loaded poly (lactic-co-glycolic) acid nanoparticles on coronary restenosis of injury-stenosis …
- Topical Rapamycin combined with pulsed dye laser (PDL) in the treatment of capillary vascular malformations—Anatomical differences in response to PDL are relevant …
- Serendipity in splendid isolation: Rapamycin
- Brain size is controlled by the mammalian target of Rapamycin (mTOR) in mice
- 4E-BP2 hardwires lymphocytes for Rapamycin sensitivity
- Effects of mechanistic target of Rapamycin signaling pathway on the estrogen-mediated NaPi-IIb protein expression in pig small intestinal epithelial cells
- Natural killer group 2D and CD28 receptors differentially activate mammalian/mechanistic target of Rapamycin to alter murine effector CD8+ T‐cell differentiation
- Activation of Mammalian target of Rapamycin in canine mammary carcinomas: an immunohistochemical study
- Rapamycin as a Potential Treatment for Obesity
- Rapamycin does not impede survival or induction of antibody responses to primary and Heterosubtypic influenza infections in mice
- … -Kuey-Jian-Tang induces autophagy in HepG2 cells via regulation of the phosphoinositide-3 kinase/Akt/mammalian target of Rapamycin and p38 mitogen …
- CWF-145, a novel synthetic quinolone derivative exerts potent antimitotic activity against human prostate cancer: Rapamycin enhances antimitotic drug-induced …
- Mammalian target of Rapamycin (mTOR), aging, neuroscience, and their association with aging-related diseases
- Understanding the cellular impact of low dose Rapamycin treatment.
- Tumor cell-derived secretory factor downregulates Semaphorin-3a in osteoblasts by activating mammalian target of Rapamycin pathway
- Mammalian target of Rapamycin inhibitor induced complete remission of a recurrent subependymal giant cell astrocytoma in a patient without features of tuberous …
- Rapamycin reverse lipopolysaccharide-induced acute lung injury through acti-vating autophagy flux
- Regulation of hypoxia-inducible factor-1α, regulated in development and DNA damage response-1 and mammalian target of Rapamycin in human placental BeWo …
- Phase II trial of gemcitabine plus Rapamycin as second line in advanced osteosarcoma: A Spanish Group for Sarcoma Research (GEIS) Study.
- Combined antitumor gene therapy with herpes simplex virus-thymidine kinase and short hairpin RNA specific for mammalian target of Rapamycin
- Preventive and therapeutic effects of Rapamycin against autoimmune hepatitis and liver fibrosis and possible mechanisms
- Rapamycin enhances IFN-γ and IL-4 production in co-culture of gδ T and dendritic cells from mice with lipopolysaccharide-induced acute lung injury
- Expression of Concern. A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet …
- Topical Rapamycin for angiofibromas in patients with tuberous sclerosis: how does it work in clinical practice?
- Dual inhibition of phosphatidylinositol 3-kinase/mammalian target of Rapamycin and mitogen activated protein kinase pathways in non-Hodgkin lymphoma
- Effects of dietary soy protein concentrate on growth, digestive enzymes activities and target of Rapamycin signaling pathway regulation in juvenile soft-shelled …
- Growth inhibitory effect of Rapamycin in Hodgkin-lymphoma cell lines characterized by constitutive NOTCH1 activation
- Pharmacology of mammalian (mechanistic) target of Rapamycin (mTOR) inhibitors
- Role of the phosphatidylinositol-3-kinase/Akt/target of Rapamycin pathway during ambidensovirus infection of insect cells
- Mechanism of Polypeptide Extract from Scorpion Venom Combined Rapamycin in Enhancing Autophagy of H22 Hepatoma Cells: an Experimental Study
- In vitro study of effects and mechanism of Rapamycin-induced autophagy in keloid fibroblasts
- Using the mycelium-covered cereals as an efficient inoculation method for Rapamycin fermentation in a 15-L fermenter using Streptomyces hygroscopicus
- Erratum to: Optimization of adipose tissue-derived mesenchymal stem cells by Rapamycin in a murine model of acute graft-versus-host disease
- Rapamycin increases RSV RNA levels and survival of RSV-infected dendritic cell depending on T cell contact
- Efficacy of Rapamycin therapy in the women with metastatic breast cancer in West Iran
- Mechanisms for reversal of pulmonary hypertension by Rapamycin in rats
- Roles of Mechanistic Target of Rapamycin in the Adaptive and Innate Immune Systems
- An Analytical Approach for Insulin-like Growth Factor Receptor 1 and Mammalian Target of Rapamycin Blockades in Ewing Sarcoma
- Potential future Indication of Rapamycin Analogs for the Treatment of solid Tumors
- Abstract B59: Dual mTOR kinase inhibitor reverses Rapamycin resistance in prostate cancer cells
- Effects of Ras homolog gene family, member C gene silencing combined with Rapamycin on hepatocellular carcinoma cell growth
- A phase I/II multi-center study of intravesical nanoparticle albumin-bound Rapamycin (ABI-009) in the treatment of BCG refractory non-muscle invasive bladder cancer.
- Costimulatory blockade and use of mammalian target of Rapamycin inhibitors: avoiding injury part 1
- Autologous Rapamycin-Resistant T Cell Therapy of Multiple Myeloma
- Association of mammalian target of Rapamycin gene polymorphisms with the risk of pediatric epilepsy
- Immune-Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor gd T Cells
- The Effect of Rapamycin on Penicillin-Induced Epileptiform Activity in Rats: An Electrophysiological Study
- PT684. Treatment with Rapamycin improves deficits of social interaction in the mice exposed in utero to valproic acid
- Comparable neuroprotective effect of Rapamycin against low and high rotenone concentrations in primary dopaminergic cell culture
- Enhanced antitumor activity of Rapamycin and genipin, a UCP-2 inhibitor, in lung cancer
- … nephrectomy specimens as a predicting factor of progression-free survival in patients with metastatic renal cell carcinoma treated with mammalian target of Rapamycin …
- Rapamycin results in Bim-mediated loss of thymic regulatory T cells during development in organ culture
- Mammalian target of Rapamycin (mTOR) inhibition in advanced bronchial carcinoids
- Sann-Joong-Kuey-Jian-Tang decreases the protein expression of mammalian target of Rapamycin but increases microtubule associated protein II light chain 3 …
- Rapamycin protects ova induced asthma in mice through regulating autophagy
- Oleuropein potently inhibits mammalian target of Rapamycin: possible involvement of tandem anomeric hyperconjugation–Michael reaction
- Structural studies on the target of Rapamycin complex 1
- Risk factors associated with mammalian target of Rapamycin inhibitor withdrawal in kidney transplant recipients
- Rapamycin Enhances the Suppressive Capacity of Ex Vivo Expanded Regulatory T Cells (Tregs) Isolated From Pediatric Thymus
- Activation of mTOR signaling pathway in cancer stem cells of nasopharyngeal carcinoma and inhibitive effect of Rapamycin against the cancer stem cells
- Catalytic mammalian target of Rapamycin inhibitors as antineoplastic agents
- Efficacy of Rapamycin in Tuberous Sclerosis–Associated Hypopigmented Macules: Back to the Future
- Topical Rapamycin suppresses lacrimal gland inflammation in a mouse model of Sjögren’s Syndrome
- Phase II study of dual phosphoinositol-3-kinase (PI3K) and mammalian target of Rapamycin (mTOR) inhibitor BEZ235 in patients with locally advanced or metastatic …
- Changes of Sexual Behaviors in Rapamycin-injected Cichlid Fish Astatotilapia burtoni Males
- Down-regulation of MAPKs and NF-κB Signaling is Involved in Rapamycin Suppression of
- Molecular characterization and expression analysis of target of Rapamycin (TmTOR) in coleopteran insect Tenebrio molitor
- Comparative proteomic analysis of Rapamycin versus cyclosporine combination treatment in mouse podocytes
- The role of Rapamycin-eluted stent in vascular endothelial injury
- A phase I/II study of albumin-bound Rapamycin nanoparticles in the treatment of bacillus calmette-guerin refractory non-muscle invasive transitional cell bladder cancer …
- Rapamycin-topotecan combination exhibited enhanced antitumor efficacy compared to topotecan used alone in cisplatin-resistant ovarian cancer cells.
- Probing mitosis by manipulating the interactions of mitotic regulator proteins using Rapamycin-inducible dimerization
- Studies on the response to, and recovery from, Rapamycin in Saccharomyces cerevisiae
- P-113 Mammilian target of Rapamycin (mTOR) and autophagy in hepatitis C virus-related hepatocellular carcinoma: relation to tumor progression
- LB-S&T-03 A PHASE 1/2 STUDY OF ALBUMIN-BOUND Rapamycin NANOPARTICLES IN BACILLUS CALMETTE-GUERIN REFRACTORY NON-MUSCLE …
- Novel insights into regulation of Target of Rapamycin Complex 2 by hyperosmotic stress.
- Halofuginone synergistically enhances anti-proliferation of Rapamycin in T cells and reduces cytotoxicity of cyclosporine in cultured renal tubular epithelial …
- Neuroprotective effect of Rapamycin in the retina
- Rapamycin for vascular tumor/malformation
- Identifying rational combination therapies with Rapamycin for the treatment of epithelial cancers
- The pilot study on Rapamycin retarding the differentiation of RPE cells in vitro
- … hematological disorders observed in Shwachman-Diamond syndrome: mTOR and STAT3 hyper-phosphorylation in CD4+ and CD8+ T cells and efficacy of Rapamycin …
- In vivo Toll‐like receptor 5 (TLR5) imaging with radiolabeled anti‐TLR5 monoclonal antibody in Rapamycin‐treated mouse allogeneic skin transplantation model
- Rapamycin and Chloroquine: The
- The role of Rapamycin-eluted stent in vascular endothelial injury
- Rapamycin Improves Vascular Remodeling in a Controlled Rat Model of Monocrotaline-induced Pulmonary Hypertension
- Effects of leucine and histidine on milk protein synthesis via mammalian target of Rapamycin signaling pathway in the bovine mammary epithelial cells.
- Effects of tetrandrine and caffeine on cell viability and expression of mammalian target of Rapamycin, phosphatase and tensin homolog, histone deacetylase 1 …
- Neurotensin and Corticotropin‐releasing Hormone Synergistically Activate Human Microglia through Mammalian Target of Rapamycin Complex 1 (mTORC1)
- Determination of GDC‐0980 (apitolisib), a small molecule dual phosphatidylinositide 3‐kinase/mammalian target of Rapamycin inhibitor in dog plasma by LC‐MS/MS …
- Rapamycin POLYMER NANOTHERAPEUTICS FOR PULMONARY HYPERTENSION TREATMENT
- FCT-14: Topical 0.2% Rapamycin for angiofibromas due to tuberous sclerosis complex (TSC)
- Effect of Rapamycin on apoptosis of mouse astrocytes in vitro
- Mammalian Target of Rapamycin Signaling Pathways and Depression
- Serendipity in splendid isolation: Rapamycin
- Regulation of Hepatic Metabolism by the Mechanistic Target of Rapamycin
- Therapeutic effect of Rapamycin on the clinical and radiological aspects in patients with multiple sclerosis
- Rapamycin inhibits the phosphorylation of mSin1 by targeting a new mTOR complex
- Effect of Rapamycin on Proliferation and Cell Cycle of Human Bladder Carcinoma Cell Line 5637
- FP471 EFFECT OF Rapamycin ON EXPRESSION OF IL17 AND TLR4 IN EARLY STAGE OF DN RATS
- Structural and functional characterization of Rapamycin-resistant TORC2
- Improvement of antitumor effect of ionizing radiation to treat nasopharyngeal carcinoma in combination with Rapamycin
- Effects and mechanisms of Rapamycin on renal interstitial fibrosis in rats
- Congenital Hyperinsulinism; Effects of Rapamycin on Min6 Pancreatic?-Cell Line
- The Adjuvant Effect of Rapamycin for a New Multi-stage Subunit Vaccine Candidate LT69
- Effect of Rapamycin on Expression of Survivin and Caspase-3 and Its Influence on K562 Cell Ultrastructure
- Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells
- The Impact of Rapamycin and Metformin on Genome Organization and Function in Normal Human Fibroblasts
- Alterations of the electrophysiological properties from cortical layer 5 pyramidal neurons in temporary Rapamycin-treated rodent brain slices
- The Effects of Rapamycin on the Unfolded Protein Response in Relation to Healthy Aging
- The Effect of Rapamycin on Mitochondrial Electron Transport Chain (ETC) Activity and Superoxide Production
- Sensitivity of esophageal squamous cell carcinoma cells to Rapamycin can be improved by siRNA-interfered expression of p70S6K
- Rapamycin Activates TGF Receptor Independently of Its Ligands: Implications for Endothelial Dysfunction
- Effect of Rapamycin on the migration of human epidermal cell line HaCaT and its possible molecular mechanism
- Anticancer effect of Rapamycin on MCF-7 via downregulation of VEGF expression Animal
- Study on Effects and Mechanism of Rapamycin on Invasion and Metastasis of Cervical Cancer HeLa Cells
- Is it necessary to investigate Rapamycin-modulated autophagy during the development of experimental osteoporosis in female rat?
- Dual mTOR kinase inhibitor overcomes Rapamycin resistance in vitro
- Anti-fibrotic effects of Rapamycin by activation of autophagy in scarforming fibroblasts
- Host Ingestion of Rapamycin Increased Nematode and Cestode Reproduction
- A Novel Multiple Sclerosis Model Utilizing Cuprizone and Rapamycin
- CP-173 Topical 0.1% Rapamycin for angiofibromas in a paediatric patient with tuberous sclerosis
- Identification of a natural compound as mammalian target of Rapamycin kinase inhibitor
- Characterization and Rapamycin Treatment Of Laryngotracheal Stenosis, In Vitro and In Vivo
- Chronic mTOR inhibition by Rapamycin and Diabetes: What is the Role of Mitochondria?
- Mammalian target of Rapamycin inhibitors: A paradigm shift in current immunosuppression protocols
- Augmentation of nonsense mediated decay by Rapamycin
- Sphingolipids mediate the signals for all the essential functions of Target Of Rapamycin Complex 2
- Effect of Rapamycin on proliferation of rat heart valve interstitial cells in vitro
- Rapamycin adjuvant therapy did not improve the outcome of severe influenza virus infection in an experimental mouse model system
- Advance in research on the relationship between mammalian target of Rapamycin signaling pathway and ophthalmic diseases
- Rapamycin expands t-regulatory cells and improves implantation and live birth rates in a murine model
- Outcome of Rapamycin Therapy for Post Transplant-Lymphoproliferative Disorder after Kidney Transplantation: Case Series
- Effects of Rapamycin and 3-MA on motor behavior and autophagy related protein LC3 in PD model mice
- The Breeding of High-yielding Actinoplanes of Rapamycin
- Changes in expression of autophagy-related proteins, Beclin-1 and LC3, and effects of Rapamycin on their expression in hypoxic-ischemic hippocampus
- Enhanced antitumor activity of Rapamycin and genipin, a UCP-2 inhibitor, in lung cancer.
- Rapamycin rescues the innate immune/inflammatory response in the retina of the Ndufs4 mouse
- In Vivo Sustained Release of Rapamycin (Sirolimus) from a Biodegradable Intravitreal Device
- Combination therapy of FK228 with Rapamycin synergistically promotes human breast cancer cell apoptosis by DNA damage and cell cycle arrest
- 4-(N-Phenyl-N′-substituted benzenesulfonyl)-6-(4-hydroxyphenyl) quinolines as inhibitors of mammalian target of Rapamycin
- Rapamycin Induced Acute Myelogenous Leukemia U937 Cell Autophagy and Apoptosis
- THE EFFECTS OF Rapamycin ON THE GLYCOLYSIS IN BREAST CANCER CELL LINES MCF-7 & MDAMB231
- Sensitivity of esophageal squamous cell carcinoma cells to Rapamycin can be improved by si RNA-interfered expression of p70S6K
- Efficacy of Rapamycin and paclitaxel eluting stent implantation in treatment of coronary artery disease
- Investigating novel interaction partners of amyloid precursor protein: the mechanistic target of Rapamycin and pikyve complex
- Small molecules as tool compounds to probe Target of Rapamycin (TOR) signaling
- Effect and Mechanism of Rapamycin Inhibiting mTOR on Heart Valve Cell Calcification in Experimental Rats
- Reperfusion Therapy With Rapamycin Prevents Myocardial Injury in Type 2 Diabetic Rabbits
- Cardiac-specific Overactivation of the Mechanistic Target of Rapamycin Complex 1 Induces Metabolic, Structural and Functional Remodeling
- Target of Rapamycin signaling mediates vacuolar fission caused by endoplasmic reticulum stress in S. cerevisiae.
- Effect of Rapamycin on the Gene Expression Signature of Focal Lesions in a Model of Progenitor‐Derived HCC
- Microinjection Technique to Relieve Neuropathic Pain by Infusion of Rapamycin into the Insular Cortex
- Rapamycin-based macrocyclic library development and Equilibrative Nucleoside Transporter 1 (ENT1) inhibition
- Abstract T P79: Rapamycin Improves Outcome Post Stroke Injury by Enhancing Autophagy in Neuronal Cells
- Investigating efficacy of combinational use of Rapamycin and Valproic acid in treatment of triple negative breast cancer cells
- Preparation of nearly monodispersed polycaprolactone nano-particles loaded with the immunosuppressive drug Rapamycin by membrane micromixing …
- Rapamycin Treatment Regulates miRNAs Associated With Mitochodrial and Endoplasmic Reticulum Functions in a Pig Model of Miocardial Ischemia-reperfusion …
- Rapamycin Regulates Autophagy and Cell Adhesion in Induced Pluripotent Stem Cells
- Rapamycin in combination with gemcitabine reduced viability, growth and metastasis of the murine osteosarcoma cell line LM8 in vitro and in vivo
- Characterizing the Mechanistic Target of Rapamycin Complex 2 Pathway in Glioblastoma Multiforme
- Role of hippocampal mammalian target of Rapamycin signaling pathway in inflammatory pain in rats
- Impact of autophagy on allorejection and underlying mechanisms in Rapamycin-treated allotransplantation model
- Molecular mechanism of amino acids in regulation of mammalian target of Rapamycin complex 1 signaling pathway.
- Research progress of mammalian target of Rapamycin and hypoxia-inducible factor-1 in malignant tumors
- Topical Rapamycin Therapy to Alleviate Cutaneous Manifestations of Tuberous Sclerosis Complex
- Inhibiting the mammalian target of Rapamycin as an adjunctive therapy for cerebral malaria (MPF7P. 714)
- Effects of Rapamycin on expression of six kinds miRNAs in RAW264. 7 macrophages and research on miR-20a’s targeted regulation of ATG16L1 gene expression
- Linking Metabolic and Structural Remodeling by Cardiac‐Specific Activation of the Mechanistic Target Of Rapamycin Complex 1
- Microencapulated Rapamycin prevents carcinogen and inflammation driven colon cancer through immune mechanisms
- Rapamycin-and paclitaxel-eluting stents for prevention of cardiovascular events: effectiveness and safety
- Mammalian target of Rapamycin inhibition with enterically given Rapamycin alters immunity and gut flora in young and aged wild type mice and extends life of …
- Evolution of disease activity and biomarkers on and off Rapamycin in 28 patients with autoimmune lymphoproliferative syndrome
- Rapamycin-INDUCED RESCUE OF AUTOPHAGY DRIVES GLIOBLASTOMA STEM/PROGENITOR CELLS DIFFERENTIATION
- Rapamycin Prevents Bronchiolitis Obliterans through Increasing Regulatory B Cells Infiltration in A Murine Tracheal Transplantation Model
- Environmental Signaling through the Target of Rapamycin Complex 1 (TORC1) and the Regulation of Epigenetic Mechanisms
- Rapamycin Blocks a Key Thermogenesis Pathway in White Adipose Tissue: Diabetes/Obesity Implications
- Rapamycin Reverses Lymphatic Abnormalities In A Transgenic Mouse Model Of Pulmonary Lymphangiectasia
- Immunofluorescent approaches to investigate the mammalian target of Rapamycin (mTOR) complex in human skeletal muscle
- Rapamycin Is Highly Effective in a Mouse Model of Immune-Mediated Bone Marrow Failure By Mechanisms Distinct from Cyclosporine
- Th1, Th2 and Th17 cytokine profile in patients with multiple sclerosis following treatment with Rapamycin
- A Novel Compound Tanshinol Prolongs Cardiac Allograft Survival Induced by Rapamycin
- Estimates in several industrial yeast strains ploidy by flow cytometer with Rapamycin.
- Study of the effect of Rapamycin on mTOR complex using capillary isoelectric focusing coupled with laser induced fluorescence-detector
- Drug Development against Rapamycin-resistant Cancers via Leucyl-tRNASynthetase
- Assessing efficacy of combinational therapy of Rapamycin and Tamoxifen on estrogen receptor positive MCF7 breast cancer cells
- Topical Rapamycin treatment is effective in hypopigmented macules of tuberous sclerosis
- The influence of the Target of Rapamycin (TOR) on starch metabolism in Arabidopsis thaliana
- Rapamycin treatment of normal human fibroblasts increases the transcriptional abundance of genes involved in cytokine-cytokine receptor signalling
- D44 FIRST LINE OF DEFENSE: AIRWAY RESPONSE TO INFECTIONS AND IRRITANTS: Rapamycin Protects Ova Induced Asthma In Mice Through Regulating …
- Anti‑migratory effect of Rapamycin impairs allograft imaging by 18F‑fluorodeoxyglucose‑labeled splenocytes
- GW27-e0513 inhibition of mammalian target of Rapamycin complex 1 protects against reperfusion injury in heart through STAT3 signaling
- Rapamycin Preferentially Inhibits IL5+ Th2 Cell Proliferation through the mTORC1/S6 Kinase Pathway
- Abstract B055: The impact of Rapamycin and tacrolimus treatment on resident CD8+ T-cell populations in cutaneous squamous cell carcinoma
- Abstract T P85: Mammalian Target of Rapamycin (mTOR) Signaling Pathway Mediates Cerebral Ischemic Brain Damage
- GW27-e0035 Delayed reendothelialization with Rapamycin is rescued by the addition of nicorandil in balloon-injured rat carotid arteries
- Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes Molecular and cell biology of lipids
- Mammalian target of Rapamycin inhibitors are promising T cell lymphoma treatment agents that synergize with ERβ agonists in vitro but not in vivo (VAC3P. 1061)
- Protective role and the mechanism of Rapamycin against concanavalin A (ConA) induced autoimmune hepatitis in mice
- The Evolving Role of Mammalian Target of Rapamycin (mTOR) Inhibitors in Renal Cell Carcinoma
- Confirmation Of The Cellular Targets Of Benomyl And Rapamycin And Studies Into The Mode Of Action Of Cationic Amphiphilic Drugs (CADs)
- Binge Drinking With Protein Kinase C Epsilon: A Role for Mammalian Target of Rapamycin Complex 2?
- Rapamycin Treatment Inhibits the Progression of Optic Neuritis Mediated Visual Loss in Experimental Autoimmune Encephalomyelitis (EAE) Mice
- The Role of Protein Kinase C in Mammalian Target of Rapamycin Signaling and its Therapeutic Implications in Non-Small Cell Lung Cancer
- Cell synchronization by Rapamycin improves the developmental competence of porcine SCNT embryos
- Mammalian target of Rapamycin inhibitors against hepatocellular carcinoma recurrence after liver transplantation
- Reperfusion Therapy With Rapamycin Prevents Myocardial Injury by Induction of Cardiac MicroRNA-302a in Diabetic Rabbits
- Effects of Rapamycin on amyloid β-protein induced impairments of working memory and synaptic plasticity in rats
- Specificity to capture endothelial progenitor cells in the peripheral blood by CD34 antibody applied on a Rapamycin eluting stent
- inhibition of glucose metabolism in neuroendocrine tumors by lanreotide, sunitinib, and Rapamycin
- Effects of Rapamycin and Rapamycin-loaded Poly (lactic-co-glycolic) Acid Nanoparticles on Apoptosis and Expression of bcl-2 and p27 (kip1) Proteins of Human …
- Differential Roles of Mammalian Target of Rapamycin (mTOR) in Phrenic Long‐Term Facilitation
- Abstract B12: Rapamycin-induced miR-21 promotes the survival of mTORC1 hyperactivated cells in tuberous sclerosis complex models
- Rapamycin Increases the Thrombogenic Potential of Neutrophil Extracellular Traps (NETs): Potential Mechanism of Prothrombotic Drug-Eluting Stents
- Modulation of mTOR and p53 signaling using Rapamycin plus CP-31398 inhibits growth and progression of urothelial carcinoma in-vivo
- Reperfusion Therapy with Rapamycin Prevents Myocardial Injury and restores Plasma Levels of Stress‐Sensitive microRNA‐191 in Conscious Diabetic Rabbits
- Rapamycin, an evolving role in up-regulation of autophagy to improve stroke outcome and increase neuronal survival to stroke type injuries
- Effect of Electro-acupuncture on Mammalian Target of Rapamycin Expression in Hypoxic-ischemic Encephalopathy Newborn Rats
- Rapamycin enhances Sox9 expression during chondrogenic differentiation of amniotic fluid stem cells
- Short-term prognostic implication for patients with ST-elevation myocardial infarction undergoing domestic Rapamycin drug-eluting stent implantation
- The Role of Hypoxia on Pyruvate Kinase M2, mammalian Target of Rapamycin, Mitochondrial Function, and Cell Invasion in the Trophoblast
- Rapamycin ameliorates experimental autoimmune uveoretinitis by inhibiting Th1/Th2/Th17 cells and upregulating CD4+ CD25+ Foxp3 regulatory T cells
- Mammalian target of Rapamycin is required for axon growth of adult dorsal root ganglion neurons
- Rrd1p, an RNA Polymerase II‐specific Prolyl Isomerase and Activator of Phosphoprotein Phosphatase, Promotes Transcription Independently of Rapamycin …
- Rapamycin Protects Diabetic Heart Against Ischemia-reperfusion Injury by Inhibiting JNK and STAT4
- Effects of Mammalian Target of Rapamycin inhibition on Circuitry Changes in the Dentate Gyrus of Mice after Focal Brain Injury
- Rapamycin ameliorates ethambutol induced toxic optic neuropathy by facilitating mitophagy
- Renal angiomyolipomas, Tuberous Sclerosis Complex and mammalian target of Rapamycin inhibitors
- Insulin stimulates retinal ganglion cell dendrite regeneration through activation of the mammalian target of Rapamycin complex 1and complex 2
- Reperfusion Therapy With Rapamycin Prevents Myocardial Ischemic Injury, Through Activation of AKT and ERK
- Selective TSC1 deletion in smooth muscle results in mTOR signaling activation and development of pulmonary hypertension that can be reversed by Rapamycin
- Alteration of mammalian target of Rapamycin signaling pathways in an In Vitro model of repetitive mild traumatic brain injury
- DNA methyltransferase expression and proliferation status of metastatic breast cancer cell line after prolonged and repeated Rapamycin and melatonin application
- Adopting the Rapamycin trapping assay to track the trafficking of murine MHC class I alleles, H-2K b
- Positive expression of phosphorylated mammalian target of Rapamycin in gastric caner and its clinicopathological and prognostic significance: a meta analysis
- Lipophilic bisphosphonates plus Rapamycin: a deadly combination for KRAS-mutated lung adenocarcinoma
- Preparation of Rapamycin and methyl-β-cyclodextrin complexes using a single-step, organic solvent-free supercritical fluid process: An approach to enhance the …
- Rapamycin restores BDNF-LTP and the persistence of long-term memory in a model of Down’s syndrome
- Evaluation of Rapamycin for the Treatment of Autoimmune-Mediated Dry Eye in a Mouse Model of Sjögren’s Syndrome
- The role of amino acid-induced mammalian target of Rapamycin complex 1 (mTORC1) signaling in insulin resistance
- B62 THE BIOLOGY OF SCARRING. WHERE ARE WE NOW: Rapamycin Insensitive mTOR Signalling Promotes Tgf-[Beta] Induced Pro-Fibrotic Gene Expression In …
- Diazoxide preconditioning is mediated by mechanistic target of Rapamycin (mTOR) and S6 Kinase (S6K)
- Rapamycin Insensitive mTOR Signalling Promotes TGF-β Induced Pro-Fibrotic Gene Expression In Human Lung Fibroblasts
- AME is a Mammalian Target of Rapamycin kinase inhibitor on EGF-induced neoplastic cell transformation
- B52 NEONATAL LUNG DISEASE: FROM BENCH TO BABIES: Rapamycin Reverses Lymphatic Abnormalities In A Transgenic Mouse Model Of Pulmonary …
- Comment on retinal ganglion cell electrical activity, mammalian target of Rapamycin signaling and optic nerve regeneration
- Rapamycin directly inhibits T cell lymphoma proliferation at high doses and facilitates immune-independent toxin-mediated killing at a low dose in vivo.
- In vivo Rapamycin-treated mouse allogeneic transplanted skin imaging with radiolabeled anti-Toll-like receptor 5 (TLR5) mAb
- Role of Mammalian Target of Rapamycin (mTOR) Signalling in BeWo Trophoblast Differentiation and Fusion
- AKT inhibition sensitizes tumor cells to Rapamycin by enhancing the repressive function of PRS40 on mTORC1/4E-BP1 axis
- Expressions of the key proteins of the protein kinase B/mammalian target of Rapamycin signaling pathway in skin tissue and wound tissue of diabetic rats
- Control of cell fate by the mammalian target of Rapamycin (mTOR) under stress depends on eIF2α serine 51 phosphorylation
- Crucial Role of the Mammalian Target of Rapamycin (mTOR) in Activation of Human Microglia, Mast Cells and Keratinocytes, Inhibitable by Methoxyluteolin
- Differentiation therapy of the neoplastic stromal cells in giant cell tumor of bone using the US Food and Drug Administration (FDA)-approved drugs, Rapamycin …
- Effects of hydrogen-rich saline on hippocampal mammalian target of Rapamycin/tau pathway after operation in aged rats
- A Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin, GSK2126458, Inhibits Laser-Induced Choroidal Neovascularization
- Altered electrolyte homeostasis in mice with collecting‐duct‐principal‐cell select knockout of the mammalian‐target‐of‐Rapamycin (mTOR)
- MP39-09 Rapamycin INHIBITS FLCN-DEFICIENT RENAL TUMOR GROWTH IN MICE
- Haploidentical Peripheral Blood Stem Cell Transplantation after Treosulfan-Based Conditioning and Rapamycin GvHD Prophylaxis in Hodgkin Lymphoma
- Rapamycin and retinoic acid downregulate the methylation of FoXP3 after restimulation in human treg derived from naive t cells
- Fatigue with vascular endothelial growth factor receptor tyrosine kinase inhibitors and mammalian target of Rapamycin inhibitors in patients with malignancies: A meta …
- The energy sensor AMP-activated protein kinase (AMPK) signals neuronal death in glaucoma through inhibition of the mammalian target of Rapamycin (mTOR).
- Comparison of the effect of bone marrow cells infusion through the portal vein and inferior vena cava combined with short‐term Rapamycin on allogeneic islet grafts in …
- Effect of Rapamycin as an Inhibitor of the mTOR Cell Cycle Entry Complex on the Selective Lysis of Human Leukemia Cells Lines in Vitro Using 20 kHz Pulsed Low …
- Expression of phosphorylated mammalian target of Rapamycin (p-mTOR) and phosphorylated eukaryotic translation initiation factor 4E binding protein 1 in pathologic …
- Knock-in of Dnmt3a R878H Recapitulates Human Acute Myeloid Leukemia Harboring DNMT3A Mutation and Is Highly Responsive to mTOR Inhibitor Rapamycin
- Prescriber treatment patterns for tyrosine kinase inhibitors (TKI) and mammalian target of Rapamycin (mTOR) inhibitors in patients with renal cell carcinoma.
- TCT-456 Direct Implantation of Rapamycin-Eluting Stents with Bioresorbable Drug Carrier Technology Utilizing the Svelte Coronary Stent-on-a-Wire: 2-Year Follow …
- Optimal dietary alphaâ linolenic acid/linoleic acid ratio improved digestive and absorptive capacities and target of Rapamycin gene expression of juvenile grass carp …
- Rapamycin protects livers from ischemia and reperfusion Injury via both autophagy induction and mTORC2-Akt activation
- Activation of mammalian target of Rapamycin complex 1 (mTORC1) and 2 (mTORC2) is required for retinal ganglion cell dendrite regeneration after axonal injury.
- AB0061 mTOR inhibition by Rapamycin is Associated with Downregulation of Pro-Infammatory Cytokine TNFα, and Genes Involved in Bone Resoption (MMP-9 and …
- … stretch promotes mesenchymal stem cell-osteoblast lineage migration through activation of mammalian target of Rapamycin/matrix metalloproteinases signaling …
- … FOR PATIENTS WITH MULTIPLE VESSEL DISEASE AND UNPROTECTED LEFT MAIN WITH A COBALT-CHROMIUM Rapamycin ELUTING STENT: TWO YEARS …
- … acid broadly suppresses cancer metabolism and synergistically induces strong anticancer activity in combination with Etoposide, Rapamycin and UCN-01
- … Trial of Lymphocyte-Selective Pentostatin Plus Cyclophosphamide Conditioning, High Dose Sirolimus and Pre-Emptive DLI with Rapamycin-Resistant Donor CD4+ T …
- Functional Proteomics Identifies Acinus L as a Direct Insulin-and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate* DS
- Neuropeptides stimulate pro-inflammatory mediator secretion from human microglia through mammalian target of Rapamycin signaling, which is inhibited by the …
- TCT-598 Revascularization strategies for patients with multiple vessel disease and unprotected left main with a cobalt-chromium Rapamycin eluting stent (ERACI IV …
- REDOX SENSITIVE ACTIVATION OF MAMMALIAN TARGET OF Rapamycin SIGNALING COMPLEX-2 (mTORC2): ROLE OF SUPEROXIDE ANION IN ACTIVATION …
- Lifespan extension in a semelparous chordate Oikopleura dioica via developmental growth arrest: Roles of Target of Rapamycin (TOR) signaling and D type cyclins
- Rictor Oxidation and Disruption of the Mammalian Target of Rapamycin Complex 2 (mTORC2) Links Mitochondrial Oxidative Stress to Insulin Resistance in …
- INSULINE LIKE GROWTH FACTOR-1 AND LEUCINE ACTIVATE PIG MYOGENIC SATELLITE CELLS THROUGH MAMMALIAN TARGET OF Rapamycin …
- Phosphatidylinositol 3-kinase/protein kinase B/mammalian target of Rapamycin signaling pathway and epilepsy
- … standard chemotherapy: Final results of a phase I study of infusional cyclophosphamide (cy), pulse dexamethasone (dex), Rapamycin (rapa) and hydroxychloroquine …
- Combined Application of Phosphoinositide 3-Kinase and Mammalian Target of Rapamycin Inhibitors Suppresses Cell Growth and Promotes Apoptosis in …
- Clinical significance of the expression of eukaryotic initiation factor 4 E and mammalian target of Rapamycin in esophageal squamous carcinoma tissues
- MP39-11 DECREASING SURVIVIN BY YM155 REVERSES Rapamycin RESISTANCE IN RENAL CANCER
- Targeted inhibition of phosphoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) sensitizes pancreatic cancer cells to doxorubicin without …
- ID: 21: ALTERNATIVE Rapamycin TREATMENT REGIMENS MITIGATE THE IMPACT OF Rapamycin ON GLUCOSE HOMEOSTASIS AND THE IMMUNE SYSTEM …
- MP39-06 ENHANCED CELL PROLIFERATION AND INCREASED RESISTANCE TO MAMMALIAN TARGET OF Rapamycin INHIBITORS BY inhibition OF 4E …
- MP65-08 A PHARMACODYNAMIC PHASE 0/I STUDY OF ORAL Rapamycin IN PATIENTS UNDERGOING RADICAL CYSTECTOMY FOR BLADDER CANCER
- … of milk protein synthesis by energy and essential amino acids through adenosine 5′-monophosphate-activated protein kinase/mammalian target Rapamycin …
- … on apoptosis of HL-60 leukemic cells via the regulation of the phosphatidylinositol 3-kinase/serine/threonine protein kinase/mammalian target of Rapamycin signaling …
- inhibition of Galectin-1 sensitizes oncogenic H-Ras to Rapamycin treatment
- FCT 1-1 Oral sirolimus (Rapamycin) on 22 patients with various types of vascular anomalies
- 293. Optimal In Vivo Treg Induction and Suppression of Immune Responses By Synergistic Use of Rapamycin and FLT3 Ligand
- Abstract LB-027: inhibition of mammalian target of Rapamycin by Torin2, an ATP-competitive inhibitor, induces growth inhibition in adult T cell leukemia
- … of histidine on expressions of β-casein, and Janus kinases 2-signal transducer and activator of transcription 5/mammalian target Rapamycin signaling pathways related …
- 5-Azacytidine and Rapamycin: different and synergistic effect on ex vivo expansion of natural human T Regulatory cells
- Different and synergistic effect of 5-Azacytidine and Rapamycin on ex vivo expansion of natural human T Regulatory cells
- FCT-05: Topical Rapamycin: The promising therapeutic agent for lymphangioma circumscriptum
- Kinome Screen Reveals SGK1 as a Therapeutic Target for NF2: inhibition of mTORC1/2 is More Effective than Rapamycin
- P075 Prospective pilot study on combined use of pulsed dye laser and 1% topical Rapamycin of cutaneous capillary malformation
- Abstract# 1853 Behaviorally conditioning of anti-proliferative and immosuppressive effects with Rapamycin
- Abstract P622: Regulation of Neuroprotective Myeloid Cell Leukemia 1 by Rapamycin and AT2R Agonists in Dopaminergic Neuronal Cell-line
- Breast Cancer Development in Rats Under the Influence of Platelet Factor-4 (PF4) And/or Rapamycin
- EPT-13 RAPIRI I–PHASE I STUDY OF DAILY ORAL Rapamycin AND INTRAVENOUS IRINOTECAN IN CHILDREN WITH A RECURRENT/REFRACTORY …
- An overview of Rapamycin: from discovery to future perspectives
- A randomized controlled trial to establish effects of short-term Rapamycin treatment in 24 middle-aged companion dogs
- Towards natural mimetics of metformin and Rapamycin
- The role of mammalian target of Rapamycin (mTOR) in insulin signaling
- Rapamycin in mice
- Cryo-EM structure of Saccharomyces cerevisiae target of Rapamycin complex 2
- The complex roles of mechanistic target of Rapamycin in adipocytes and beyond
- Game of TOR—the target of Rapamycin rules four kingdoms
- Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism
- Rapamycin treatment attenuates age-associated periodontitis in mice
- A functional mammalian target of Rapamycin complex 1 signaling is indispensable for c‐Myc‐driven hepatocarcinogenesis
- Combination of Rapamycin and resveratrol for treatment of bladder cancer
- Mammalian target of Rapamycin (mTOR) as a potential therapeutic target in various diseases
- inhibition of mammalian target of Rapamycin signaling with Rapamycin prevents trauma-induced heterotopic ossification
- Short‐term Rapamycin treatment increases ovarian lifespan in young and middle‐aged female mice
- Low-dose Rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome
- Reperfusion therapy with Rapamycin attenuates myocardial infarction through activation of AKT and ERK
- Anti-HER2 immunoliposomes for co-delivery of paclitaxel and Rapamycin for breast cancer therapy
- Target of Rapamycin (TOR) regulates growth in response to nutritional signals
- Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and Rapamycin treatment
- Rapamycin suppresses microglial activation and reduces the development of neuropathic pain after spinal cord injury
- Emerging role for mammalian target of Rapamycin in male fertility
- Anti‐aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and Rapamycin by local application
- Rapamycin is highly effective in murine models of immune-mediated bone marrow failure
- Rapamycin reversal of VEGF-C–driven lymphatic anomalies in the respiratory tract
- Rapamycin and the inhibition of the secretory phenotype
- Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity
- Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease
- Mechanistic target of Rapamycin is necessary for changes in dendritic spine morphology associated with long-term potentiation
- The crosstalk between Target of Rapamycin (TOR) and Jasmonic Acid (JA) signaling existing in Arabidopsis and cotton
- Dietary Rapamycin supplementation reverses age‐related vascular dysfunction and oxidative stress, while modulating nutrient‐sensing, cell cycle, and senescence …
- Resistance exercise initiates mechanistic target of Rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle
- Ectopic expression of Arabidopsis Target of Rapamycin (AtTOR) improves water-use efficiency and yield potential in rice
- Microcystic lymphatic malformation successfully treated with topical Rapamycin
- Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson’s disease
- Rapamycin effectively impedes melamine-induced impairments of cognition and synaptic plasticity in Wistar rats
- Rapamycin protects sepsis-induced cognitive impairment in mouse hippocampus by enhancing autophagy
- Rapamycin inhibits spermatogenesis by changing the autophagy status through suppressing mechanistic target of Rapamycin-p70S6 kinase in male rats
- Rapamycin eye drops suppress lacrimal gland inflammation in a murine model of Sjögren’s syndrome
- Mammalian target of Rapamycin complex 2 regulates muscle glucose uptake during exercise in mice
- Evolution of disease activity and biomarkers on and off Rapamycin in 28 patients with autoimmune lymphoproliferative syndrome
- Rapamycin prevents cyclophosphamide-induced over-activation of primordial follicle pool through PI3K/Akt/mTOR signaling pathway in vivo
- Mammalian target of Rapamycin (mTOR) as a potential therapeutic target in pathological ocular angiogenesis
- Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy-and p62-dependent manners
- GTP ase ROP 2 binds and promotes activation of target of Rapamycin, TOR, in response to auxin
- Infantile Lhermitte-Duclos disease treated successfully with Rapamycin
- Rapamycin suppresses Aβ25–35-or LPS-induced neuronal inflammation via modulation of NF-κB signaling
- Post onset, oral Rapamycin treatment delays development of mitochondrial encephalopathy only at supramaximal doses
- Mammalian target of Rapamycin (mTOR): a central regulator of male fertility?
- The triangle of death in Alzheimer’s disease brain: the aberrant cross-talk among energy metabolism, mammalian target of Rapamycin signaling, and protein …
- Differential regulation of cardiac function and intracardiac cytokines by Rapamycin in healthy and diabetic rats
- Rapamycin ameliorates experimental autoimmune encephalomyelitis by suppressing the mTOR-STAT3 pathway
- Brassinosteriod Insensitive 2 (BIN2) acts as a downstream effector of the Target of Rapamycin (TOR) signaling pathway to regulate photoautotrophic growth in …
- Rapamycin prolongs the survival of corneal epithelial cells in culture
- Blocking mTOR signalling with Rapamycin ameliorates imiquimod-induced psoriasis in mice
- Rapamycin adjuvant and exacerbation of severe influenza in an experimental mouse model
- Efficacy of topical sirolimus (Rapamycin) for the treatment of microcystic lymphatic malformations
- Rapamycin inhibits oxidative/nitrosative stress and enhances angiogenesis in high glucose-treated human umbilical vein endothelial cells: role of autophagy
- Progressive slowdown/prevention of cellular senescence by CD9-targeted delivery of Rapamycin using lactose-wrapped calcium carbonate nanoparticles
- Rapamycin treatment dose‐dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell‐cycle‐associated CDK1/cyclin axis
- Fluoride-induced autophagy via the regulation of phosphorylation of mammalian targets of Rapamycin in mice leydig cells
- Modulation of nonsense mediated decay by Rapamycin
- Targeted co-delivery of polypyrrole and Rapamycin by trastuzumab-conjugated liposomes for combined chemo-photothermal therapy
- mTORC1 inhibition with Rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function
- OP16, a novel ent-kaurene diterpenoid, potentiates the antitumor effect of Rapamycin by inhibiting Rapamycin-induced feedback activation of Akt signaling in …
- Mechanistic target of Rapamycin is a novel molecular mechanism linking folate availability and cell function
- Rapamycin confers neuroprotection against colistin-induced oxidative stress, mitochondria dysfunction, and apoptosis through the activation of autophagy and mTOR …
- Neuroprotection through Rapamycin-induced activation of autophagy and PI3K/Akt1/mTOR/CREB signaling against amyloid-β-induced oxidative stress, synaptic …
- Rapamycin protects against paraquat-induced pulmonary fibrosis: Activation of Nrf2 signaling pathway
- Cell-autonomous requirement for mammalian target of Rapamycin (mTOR) in spermatogonial proliferation and differentiation in the mouse
- Mammalian target of Rapamycin inhibition counterbalances the inflammatory status of immune cells in patients with chronic granulomatous disease
- inhibition of mammalian target of Rapamycin (mTOR) signaling in the insular cortex alleviates neuropathic pain after peripheral nerve injury
- Antifibrotic effect of Rapamycin containing polyethylene glycol‐coated alginate microcapsule in islet xenotransplantation
- Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells
- Rapamycin nanoparticles localize in diseased lung vasculature and prevent pulmonary arterial hypertension
- The post‐therapeutic effect of Rapamycin in mild traumatic brain‐injured rats ensuing in the upregulation of autophagy and mitophagy
- Mammalian target of Rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death
- In vitro and in vivo degradation of Rapamycin-eluting Mg-Nd-Zn-Zr alloy stents in porcine coronary arteries
- Rapamycin maintains the chondrocytic phenotype and interferes with inflammatory cytokine induced processes
- Bifunctional elastin-like polypeptide nanoparticles bind Rapamycin and integrins and suppress tumor growth in Vivo
- Role for target of Rapamycin (mTOR) signal pathway in regulating neuronal injury after intracerebral hemorrhage
- Inactivation of regulatory-associated protein of mTOR (Raptor)/mammalian target of Rapamycin complex 1 (mTORC1) signaling in osteoclasts increases bone …
- m TOR inhibition by Rapamycin protects against deltamethrin‐induced apoptosis in PC 12 Cells
- Rapamycin-insensitive companion of mTOR (RICTOR) amplification defines a subset of advanced gastric cancer and is sensitive to AZD2014-mediated …
- Rapamycin augments immunomodulatory properties of bone marrow-derived mesenchymal stem cells in experimental autoimmune encephalomyelitis
- Effects of ketamine administration on mTOR and reticulum stress signaling pathways in the brain after the infusion of Rapamycin into prefrontal cortex
- Placentome nutrient transporters and mammalian target of Rapamycin signaling proteins are altered by the methionine supply during late gestation in dairy cows and …
- The molecular mechanism of glucagon-like peptide-1 therapy in Alzheimer’s disease, based on a mechanistic target of Rapamycin pathway
- Synergistic effect of Rapamycin and metformin against age-dependent oxidative stress in rat erythrocytes
- Thioredoxin-1 maintains mechanistic target of Rapamycin (mTOR) function during oxidative stress in cardiomyocytes
- Rapamycin sensitizes cancer cells to growth inhibition by the PARP inhibitor olaparib
- Rapamycin facilitates fracture healing through inducing cell autophagy and suppressing cell apoptosis in bone tissues
- Single and combined effect of retinoic acid and Rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells
- Hyaluronic acid nanohydrogel loaded with quercetin alone or in combination to a macrolide derivative of Rapamycin RAD001 (Everolimus) as a new treatment for …
- Combination of Rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude …
- Rapamycin attenuates acute seizure-induced astrocyte injury in mice in vivo
- Rapamycin-induced autophagy restricts porcine epidemic diarrhea virus infectivity in porcine intestinal epithelial cells
- inhibition of Cyclosporine A or Rapamycin on T lymphocyte counts and the influence on the immune responses of B lymphocytes in flounder (Paralichthys olivaceus)
- … acid transporter SLC 36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of Rapamycin, complex 1 signaling
- Pre-S2 mutant-induced mammalian target of Rapamycin signal pathways as potential therapeutic targets for hepatitis B virus-associated hepatocellular carcinoma
- Increased expression of (immuno) proteasome subunits during epileptogenesis is attenuated by inhibition of the mammalian target of Rapamycin pathway
- Rapamycin modulated brain-derived neurotrophic factor and B-cell lymphoma 2 to mitigate autism spectrum disorder in rats
- inhibition of mammalian target of Rapamycin complex 1 attenuates salt-induced hypertension and kidney injury in dahl salt-sensitive rats
- Everolimus is better than Rapamycin in attenuating neuroinflammation in kainic acid-induced seizures
- Cryptotanshinone inhibition of mammalian target of Rapamycin pathway is dependent on oestrogen receptor alpha in breast cancer
- Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin-independent signaling pathway involving mechanistic target of Rapamycin complex 2
- Combination therapy for inhibitor reversal in haemophilia A using monoclonal anti-CD20 and Rapamycin
- Berunda polypeptides: multi-headed fusion proteins promote subcutaneous administration of Rapamycin to breast cancer in vivo
- Two mTOR inhibitors, Rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS
- Combined targeting of mTOR and Akt using Rapamycin and MK-2206 in the treatment of tuberous sclerosis complex
- Rapamycin and CHIR 99021 Coordinate Robust Cardiomyocyte Differentiation From Human Pluripotent Stem Cells Via Reducing p53‐Dependent Apoptosis
- Choline kinase α mediates interactions between the epidermal growth factor receptor and mechanistic target of Rapamycin complex 2 in hepatocellular carcinoma cells …
- Usnic acid benzylidene analogues as potent mechanistic target of Rapamycin inhibitors for the control of breast malignancies
- PEGylated lipid bilayer-wrapped nano-graphene oxides for synergistic co-delivery of doxorubicin and Rapamycin to prevent drug resistance in cancers
- A brain proteomic investigation of Rapamycin effects in the Tsc1+/− mouse model
- Rapamycin promotes the survival and adipogenesis of ischemia-challenged adipose derived stem cells by improving autophagy
- Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory
- Chronic treatment with novel nanoformulated micelles of Rapamycin, Rapatar, protects diabetic heart against ischaemia/reperfusion injury
- … seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of Rapamycin …
- Inhibiting PLK1 induces autophagy of acute myeloid leukemia cells via mammalian target of Rapamycin pathway dephosphorylation
- … carcinoma recurrence after living donor liver transplantation for patients within the UCSF criteria: re-inventing the role of mammalian target of Rapamycin …
- Optimal ratios of essential amino acids stimulate β-casein synthesis via activation of the mammalian target of Rapamycin signaling pathway in MAC-T cells and …
- mTOR (mechanistic target of Rapamycin) inhibition decreases mechanosignaling, collagen accumulation, and stiffening of the thoracic aorta in elastin-deficient mice
- Brain injury-induced synaptic reorganization in hilar inhibitory neurons is differentially suppressed by Rapamycin
- Rapamycin-loaded immunoliposomes functionalized with Trastuzumab: a strategy to enhance cytotoxicity to HER2-positive breast cancer cells
- Loss of cardiac carnitine palmitoyltransferase 2 results in Rapamycin-resistant, acetylation-independent hypertrophy
- inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of Rapamycin kinase inhibitors in aggressive B-cell lymphomas
- Prognostic significance and function of mammalian target of Rapamycin in tongue squamous cell carcinoma
- Rictor/mammalian target of Rapamycin complex 2 promotes macrophage activation and kidney fibrosis
- A pilot study on using Rapamycin-carrying synthetic vaccine particles (SVP) in conjunction with enzyme replacement therapy to induce immune tolerance in …
- Kinetic modeling and analysis of the akt/mechanistic target of Rapamycin complex 1 (mTORC1) signaling axis reveals cooperative, feedforward regulation
- Neuroprotective effects of intrastriatal injection of Rapamycin in a mouse model of excitotoxicity induced by quinolinic acid
- inhibition of p70S6K does not mimic the enhancement of Akt phosphorylation by Rapamycin
- Modulation of the immune response in rheumatoid arthritis with strategically released Rapamycin
- Target of Rapamycin signaling mediates vacuolar fragmentation
- Chronic exposure to Rapamycin and episodic serum starvation modulate ageing of human fibroblasts in vitro
- Topical Rapamycin for facial angiofibromas in a child with tuberous sclerosis complex (TSC): a case report and long-term follow-up
- Mammalian target of Rapamycin (mTOR) regulates transforming growth factor-β1 (TGF-β1)-induced epithelial-mesenchymal transition via decreased pyruvate …
- Rapamycin decreased blood-brain barrier permeability in control but not in diabetic rats in early cerebral ischemia
- Enhancement of Rapamycin production by metabolic engineering in Streptomyces hygroscopicus based on genome-scale metabolic model
- Celastrol prevents cadmium‐induced neuronal cell death by blocking reactive oxygen species‐mediated mammalian target of Rapamycin pathway
- Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of Rapamycin (mTOR) signaling
- … , dedifferentiation, and Rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of Rapamycin
- Antitumor Synergism and Enhanced Survival with a Tumor Vasculature–Targeted Enzyme Prodrug System, Rapamycin, and Cyclophosphamide
- Rapamycin inhibits the proliferation of endothelial cells in hemangioma by blocking the mTOR-FABP4 pathway
- The downregulation of ATG4B mediated by microRNA-34a/34c-5p suppresses Rapamycin-induced autophagy
- The effect of Rapamycin, NVP-BEZ235, aspirin, and metformin on PI3K/AKT/mTOR signaling pathway of PIK3CA-related overgrowth spectrum (PROS)
- Treatment of port wine stains using pulsed dye laser, erbium YAG laser, and topical Rapamycin (sirolimus)—A randomized controlled trial
- Rapamycin modulation of p70 S6 kinase signaling inhibits Rift Valley fever virus pathogenesis
- Improvement in renal cystic disease of tuberous sclerosis complex after treatment with mammalian target of Rapamycin inhibitor
- Rapamycin promotes differentiation increasing βIII-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells
- Tanshinone IIA affects autophagy and apoptosis of glioma cells by inhibiting phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin signaling pathway
- Antidepressant actions of ketamine mediated by the mechanistic target of Rapamycin, nitric oxide, and Rheb
- Mesangial cell mammalian target of Rapamycin complex 1 activation results in mesangial expansion
- Preservation of anticancer and immunosuppressive properties of Rapamycin achieved through controlled releasing particles
- Improved antitumor effect of ionizing radiation in combination with Rapamycin for treating nasopharyngeal carcinoma
- Combination of IL-2, Rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells
- A mechanistic target of Rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin …
- … eukaryotic initiation factor 3C (EIF3C) suppresses proliferation and stimulates apoptosis in breast cancer cell lines through mammalian target of Rapamycin …
- The mammalian target of Rapamycin and DNA methyltransferase 1 axis mediates vascular endothelial dysfunction in response to disturbed flow
- Approaches towards the enhanced production of Rapamycin by Streptomyces hygroscopicus MTCC 4003 through mutagenesis and optimization of process …
- Triggering of eryptosis, the suicidal erythrocyte death by mammalian target of Rapamycin (mTOR) inhibitor temsirolimus
- CD9 monoclonal antibody-conjugated PEGylated liposomes for targeted delivery of Rapamycin in the treatment of cellular senescence
- Rapamycin promotes osteogenesis under inflammatory conditions
- Programmed cell death‐1 (PD‐1) checkpoint blockade in combination with a mammalian target of Rapamycin inhibitor restrains hepatocellular carcinoma growth …
- Suppression of Th17-polarized airway inflammation by Rapamycin
- Impact on autophagy and ultraviolet B induced responses of treatment with the mTOR inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in human …
- Overgrowth syndromes caused by somatic variants in the phosphatidylinositol 3-kinase/AKT/mammalian target of Rapamycin pathway
- Ketamine exhibits different neuroanatomical profile after mammalian target of Rapamycin inhibition in the prefrontal cortex: the role of inflammation and oxidative stress
- Chemokine (CC motif) ligand 18 upregulates Slug expression to promote stem‐cell like features by activating the mammalian target of Rapamycin pathway in oral …
- Rapamycin/sodium hyaluronate binding on nano-hydroxyapatite coated titanium surface improves MC3T3-E1 osteogenesis
- Biphasic Rapamycin effects in lymphoma and carcinoma treatment
- CENPH inhibits Rapamycin sensitivity by regulating GOLPH3-dependent mTOR signaling pathway in colorectal cancer
- Reciprocal regulation of target of Rapamycin complex 1 and potassium accumulation
- Rapamycin-loaded nanoporous α-Fe 2 O 3 as an endothelial favorable and thromboresistant coating for biodegradable drug-eluting Fe stent applications
- Programmed Death-1 inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4+ T Cell Proliferation
- Rapamycin enhances repressed autophagy and attenuates aggressive progression in a rat model of IgA nephropathy
- Intrauterine growth retardation promotes fetal intestinal autophagy in rats via the mechanistic target of Rapamycin pathway
- Construction of a Rapamycin-susceptible strain of the unicellular red alga Cyanidioschyzon merolae for analysis of the target of Rapamycin (TOR) function
- While reinforcing cell cycle arrest, Rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts
- Expression of (pro) renin receptor during Rapamycin-induced erythropoiesis in K562 erythroleukemia cells and its possible dual actions on erythropoiesis
- Isoimperatorin ameliorates osteoarthritis by downregulating the mammalian target of Rapamycin C1 signaling pathway
- Folic acid orchestrates root development linking cell elongation with auxin response and acts independently of the TARGET OF Rapamycin signaling in Arabidopsis …
- inhibition of mTOR pathway by Rapamycin decreases P-glycoprotein expression and spontaneous seizures in pharmacoresistant epilepsy
- Mammalian target of Rapamycin signaling is a mechanistic link between increased endoplasmic reticulum stress and autophagy in the placentas of pregnancies …
- Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of Rapamycin complex 1 (mTORC1) inhibitors
- General control nonderepressible 2 (GCN2) kinase inhibits target of Rapamycin complex 1 in response to amino acid starvation in Saccharomyces cerevisiae
- Renal function in heart transplant patients after switch to combined mammalian target of Rapamycin inhibitor and calcineurin inhibitor therapy
- Delayed and short course of Rapamycin prevents organ rejection after allogeneic liver transplantation in rats
- Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis
- … protein 1 activity by way of the calcium/calmodulin‐dependent kinase kinase–AMP‐activated protein kinase–mechanistic target of Rapamycin–p70 ribosomal S6 …
- Covalent modification of pericardial patches for sustained Rapamycin delivery inhibits venous neointimal hyperplasia
- Dynamin-dependent amino acid endocytosis activates mechanistic target of Rapamycin complex 1 (mTORC1)
- Naringin in Ganshuang Granule suppresses activation of hepatic stellate cells for anti‐fibrosis effect by inhibition of mammalian target of Rapamycin
- Rapamycin protects testes against germ cell apoptosis and oxidative stress induced by testicular ischemia-reperfusion
- miR-338-3p confers 5-fluorouracil resistance in p53 mutant colon cancer cells by targeting the mammalian target of Rapamycin
- Combination of histidine, lysine, methionine, and leucine promotes β-casein synthesis via the mechanistic target of Rapamycin signaling pathway in bovine …
- Temporal changes in mammalian target of Rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular …
- Rapamycin treatment for benign multicystic peritoneal mesothelioma: a rare disease with a difficult management
- Rapamycin preferentially inhibits human IL-5+ TH2-cell proliferation via an mTORC1/S6 kinase-1–dependent pathway
- Effect of Rapamycin treatment during post‐activation and/or in vitro culture on embryonic development after parthenogenesis and in vitro fertilization in pigs
- Glucose adsorption to chitosan membranes increases proliferation of human chondrocyte via mammalian target of Rapamycin complex 1 and sterol regulatory element …
- Use of Rapamycin in a patient with juvenile myelomonocytic leukemia: a case report
- Role of mammalian target of Rapamycin signaling in autophagy and the neurodegenerative process using a senescence accelerated mouse‑prone 8 model
- Effects of cyclosporine, tacrolimus, and Rapamycin on osteoblasts
- Neonatal mouse hippocampus: phlebotomy-induced anemia diminishes and treatment with erythropoietin partially rescues mammalian target of Rapamycin …
- Activation of the unfolded protein response in sarcoma cells treated with Rapamycin or temsirolimus
- Prenatal mechanistic target of Rapamycin complex 1 (m TORC1) inhibition by Rapamycin treatment of pregnant mice causes intrauterine growth restriction and alters …
- Progeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with Rapamycin and dimethylsulfoxide
- Therapeutic effects of Rapamycin on alcoholic cardiomyopathy
- Lycorine induces apoptosis of A549 cells via AMPK-mammalian target of Rapamycin (mTOR)-S6K signaling pathway
- … cells from reactive oxygen species through changes in autophagy and activation of phosphatidylinositol 3-kinase, protein kinas B, and mechanistic target of Rapamycin …
- … through CC Motif Chemokine Receptor 2–Dependent Phosphatidylinositol 3-Kinase-AKT–Mechanistic Target of Rapamycin Signaling and Hypoxia-Inducible …
- Autophagy activation by Rapamycin before hypoxia-reoxygenation reduces endoplasmic reticulum stress in alveolar epithelial cells
- Determination of mammalian target of Rapamycin hyperactivation as prognostic factor in well-differentiated neuroendocrine tumors
- Rapamycin alleviates inflammation and muscle weakness, while altering the Treg/Th17 balance in a rat model of myasthenia gravis
- Rapamycin efficiently promotes cardiac differentiation of mouse embryonic stem cells
- mTORC1 inhibitors Rapamycin and metformin affect cardiovascular markers differentially in ZDF rats
- Rapamycin reduced pulmonary vascular remodelling by inhibiting cell proliferation via Akt/mTOR signalling pathway down-regulation in the carotid artery–jugular vein …
- Rapamycin induces autophagy and reduces the apoptosis of podocytes under a stimulated condition of immunoglobulin a nephropathy
- inhibition of hemangioma growth using polymer–lipid hybrid nanoparticles for delivery of Rapamycin
- Phosphorylated Mechanistic target of Rapamycin (p-mTOR) and Noncoding RNA expression in follicular and Hürthle cell thyroid neoplasm
- Rapamycin suppresses hypoxia/reoxygenation‐induced islet injury by up‐regulation of miR‐21 via PI3K/Akt signalling pathway
- Evaluating the effectiveness of GTM-1, Rapamycin, and carbamazepine on autophagy and Alzheimer disease
- Probing the phosphatidylinositol 3‐kinase/mammalian target of Rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low‐grade gliomas
- IFN-γ orchestrates mesenchymal stem cell plasticity through the signal transducer and activator of transcription 1 and 3 and mammalian target of Rapamycin pathways
- Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells
- Mammalian target of Rapamycin signaling and ubiquitin proteasome–related gene expression in 3 different skeletal muscles of colostrum-versus formula-fed …
- … mediates the effect of micro RNA‐26a on cell growth, migration, and invasion in hepatocellular carcinoma through the protein kinase B/mammalian target of Rapamycin …
- Short-course Rapamycin treatment enables engraftment of immunogenic gene-engineered bone marrow under low-dose irradiation to permit long-term …
- Meta-analysis of 29 experiments evaluating the effects of Rapamycin on life span in the laboratory mouse
- Hyperactivation of mammalian target of Rapamycin complex 1 by HIV‐1 is necessary for virion production and latent viral reactivation
- Migratory properties of ex vivo expanded regulatory T cells: influence of all-trans retinoic acid and Rapamycin
- Differential role of Rapamycin in epidermis-induced IL-15-IGF-1 secretion via activation of Akt/mTORC2
- Target of Rapamycin complex 1 and Tap42‐associated phosphatases are required for sensing changes in nitrogen conditions in the yeast Saccharomyces cerevisiae
- Co‐Delivery of Disease Associated Peptide and Rapamycin via Acetalated Dextran Microparticles for Treatment of Multiple Sclerosis
- A single Rapamycin dose protects against late-stage experimental cerebral malaria via modulation of host immunity, endothelial activation and parasite …
- Attenuation of pentylenetrazole-induced acute status epilepticus in rats by adenosine involves inhibition of the mammalian target of Rapamycin pathway
- A new treatment for vascular anomalies: Six cases treated with Rapamycin
- Systemic meta-analysis assessing the short term applicability of early conversion to mammalian target of Rapamycin inhibitors in kidney transplant
- Association between high expression of phosphorylated Akt and mammalian target of Rapamycin and improved survival in salivary gland adenoid cystic carcinoma
- Mycophenolate mofetil and Rapamycin induce apoptosis in the human monocytic U937 cell line through two different pathways
- Rapamycin enhances the anti-angiogenesis and anti-proliferation ability of YM155 in oral squamous cell carcinoma
- 2,5-Dimethyl-Celecoxib Extends Drosophila Life Span via a Mechanism That Requires Insulin and Target of Rapamycin Signaling
- Rapamycin targets several pathophysiological features of immune-mediated bone marrow failure in murine models
- Rapid Rapamycin-only induced osteogenic differentiation of blood-derived stem cells and their adhesion to natural and artificial scaffolds
- Biodegradable cable-tie Rapamycin-eluting stents
- Use of sirolimus (Rapamycin) for treatment of cytopenias and lymphoproliferation linked to autoimmune lymphoproliferative syndrome (ALPS). Two case reports
- Triolimus: A multi‐drug loaded polymeric micelle containing paclitaxel, 17‐AAG, and Rapamycin as a novel radiosensitizer
- Immunosuppression With CD 40 Costimulatory Blockade Plus Rapamycin for Simultaneous Islet–Kidney Transplantation in Nonhuman Primates
- Role of triggering receptor expressed on myeloid cell-1 expression in mammalian target of Rapamycin modulation of CD8+ T-cell differentiation during the …
- Expression of miRNA-155 in carotid atherosclerotic plaques of apolipoprotein E knockout (ApoE−/−) mice and the interventional effect of Rapamycin
- Beneficial effects of Rapamycin in a Drosophila model for hereditary spastic paraplegia
- Mammalian target of Rapamycin complex 1 signalling is essential for germinal centre reaction
- MicroRNA-185-5p restores glucocorticoid sensitivity by suppressing the mammalian target of Rapamycin complex (mTORC) signaling pathway to enhance …
- Rapamycin inhibits expansion of cord blood derived NK and T cell
- Rapamycin induces human acute promyelocytic leukemia cell HL-60 autophagic apoptosis
- Mammalian target of Rapamycin inhibitors, temsirolimus and torin 1, attenuate stemness-associated properties and expression of mesenchymal markers promoted by …
- Rapamycin inhibits CaCl2-induced thoracic aortic aneurysm formation in rats through mTOR-mediated suppression of proinflammatory mediators
- Rapamycin-ameliorated diabetic symptoms involved in increasing adiponectin expression in diabetic mice on a high-fat diet
- Rapamycin-sensitive late-LTP is enhanced in the hippocampus of IL-6 transgenic mice
- Effects of the mammalian target of Rapamycin inhibitor everolimus on hepatitis C virus replication in vitro and in vivo
- Conversion to mammalian target of Rapamycin inhibitors in kidney transplant recipients with de novo cancers
- The antimalarial action of FK506 and Rapamycin: evidence for a direct effect on FK506-binding protein PfFKBP35
- Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of Rapamycin complex 2 (mTORC2)
- Rapamycin keeps the reproductive clock ticking
- Prospective pilot study on combined use of pulsed dye laser and 1% topical Rapamycin for treatment of nonfacial cutaneous capillary malformation
- Whey protein concentrate renders MDA-MB-231 cells sensitive to Rapamycin by altering cellular redox state and activating GSK3β/mTOR signaling
- Insights into the metabolic mechanism of Rapamycin overproduction in the shikimate-resistant Streptomyces hygroscopicus strain UV-II using comparative …
- Mammalian target of Rapamycin (mTOR)/nitric oxide system possibly modulate antidepressant-like effect of 17α-ethinyl estradiol in ovariectomized mice
- Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the Rapamycin pathway in spheroid cancer stem …
- An insight of Rapamycin against cadmium’s neurotoxicity
- Mechanistic target of Rapamycin (mTOR): A mediator of social development
- Prognostic Significance of periostin and mammalian target of Rapamycin (mTOR) in locally advanced esophageal squamous cell carcinoma
- Rapamycin additively extends lifespan in short-and long-lived lines of the nematode Caenorhabditis remanei
- Chronic Rapamycin treatment improved metabolic phenotype but inhibited adipose tissue browning in high-fat diet-fed C57BL/6J mice
- Effects of mTOR Inhibitor Rapamycin on Burkitt’s Lymphoma Cells
- Metabolic impact of Rapamycin (sirolimus) and B-estradiol using mouse embryonic fibroblasts as a model for lymphangioleiomyomatosis
- Effects of Rapamycin on life span and on expression of TOR and S6K in Brachionus calyciflorus (Rotifera)
- Mammalian target of Rapamycin complex 1 and FoxO1 in the transcriptional control of lipolysis and de novo lipogenesis
- Nudix-type motif 2 contributes to cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of Rapamycin complex 1 localization
- De Novo Donor-Specific Antibody Formation in Tacrolimus-Based, Mycophenolate Versus Mammalian Target of Rapamycin Immunosuppressive Regimens.
- PPAR gamma coactivator 1 beta (PGC-1β) reduces mammalian target of Rapamycin (mTOR) expression via a SIRT1-dependent mechanism in neurons
- Effects of Rapamycin on clinical manifestations and blood lipid parameters in different preeclampsia-like mouse models
- IL-21 augments Rapamycin in expansion of alpha fetoprotein antigen specific stem-cell-like memory t cells in vitro
- The relationship between preptin, Forkhead box protein O1 and mechanistic target of Rapamycin levels in prediabetic patients.
- Assessment of Response of Kidney Tumors to Rapamycin and Atorvastatin in Tsc1+/− Mice
- Comparison of tyrosine kinase inhibitor versus mammalian target of Rapamycin inhibitor as second-line molecular-targeted therapy for patients with poor-risk …
- Mammalian target of Rapamycin/eukaryotic initiation factor 4F pathway regulates follicle growth and development of theca cells in mice
- Invariant natural killer T cells treated with Rapamycin or transforming growth factor-β acquire a regulatory function and suppress T effector lymphocytes
- Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of Rapamycin
- Topical Rapamycin for facial angiofibromas in tuberous sclerosis complex
- Moderate mammalian target of Rapamycin inhibition induces autophagy in HTR8/SVneo cells via O‐linked β‐N‐acetylglucosamine signaling
- Fluorine-18-FDG PET/CT in a patient with angiomyolipoma: Response to mammalian target of Rapamycin inhibitor therapy
- The influence of Rapamycin on the early cardioprotective effect of hypoxic preconditioning on cardiomyocytes
- THU0245 Mammalian target of Rapamycin pathway might contribute the minor salivary gland changes in both sjogren’s syndrome and systemic sclerosis patients
- Targeted dendritic cell therapy utilising antibody-displaying porous silicon nanoparticles loaded with Rapamycin
- THU0176 Efficiency and safety of Rapamycin combined with low-dose IL-2 treatment compared with methotrexate in patients with rheumatoid arthritis
- Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002
- Nutrient medium optimization for Streptomyces hygroscopicus, a producer of Rapamycin pharmaceutical substance
- Autophagy plays an important role in Rapamycin-mediated primary cultured neonatal rat cardiac myocytes death
- Rapamycin therapy for neonatal tuberous sclerosis complex with cardiac rhabdomyomas: A case report and review
- Extraction of Rapamycin (sirolimus) from Streptomyces Rapamycinicus using ultrasound
- Effects of small rna interference targeting mammalian target of Rapamycin on paraquat-induced pulmonary fibrosis in rats
- Rapamycin enhances the antiproliferative effect of transforming growth factor‑β on MCF‑7 human breast cancer cells
- … domain 2-mediated signaling pathway in human dendritic cells in an X-linked inhibitor of apoptosis protein and mammalian target of Rapamycin-dependent …
- Extending Lifespan by Inhibiting the Mechanistic Target of Rapamycin (mTOR)
- Expression profile of mammalian target of Rapamycin‐related proteins in graft biopsy specimens: Significance for predicting interstitial fibrosis after kidney …
- Surendra Nath Sehgal: A pioneer in Rapamycin discovery
- Rapamycin attenuates atrial fibrosis in 5/6 nephrectomized rats by inhibiting mammalian target of Rapamycin and profibrotic signaling
- Nitrogen starvation and Rapamycin both induce autophagic degradation of proteasome complexes
- BRAF gene alterations and enhanced mammalian target of Rapamycin signaling in gangliogliomas
- Monitoring Rapamycin treatment response in lymphangioleiomyomatosis with [18F] fluoroethylcholine PET
- Corrigendum: Ectopic expression of Arabidopsis Target of Rapamycin (AtTOR) improves water-use efficiency and yield potential in rice
- Historical story on natural medicinal chemistry: Rapamycin
- Effect of immobilisation on production of Rapamycin by Streptomyces hygroscopicus
- Themes: Title: Investigating Protein Binding Intractions of Rapamycin: pH variations
- Effect of Rapamycin on early stage apoptosis of neutrophils in Sprague‑Dawley rats with acute lung injury
- Tyrosine Kinase and Mammalian Target of Rapamycin Inhibitors in the Treatment of Advanced Renal Cell Carcinoma: Practical Clinical Implications of Pharmacologic …
- Profile of Michael N. Hall, 2017 Albert Lasker Basic Medical Research Awardee: Target of Rapamycin, cell growth, and translational control
- Lipid Sensing by Mammalian Target of Rapamycin
- The Pharmacodynamic Functions of Low-Dose Rapamycin as a Model for Universal Influenza Protection
- PERAN MAMMALIAN TARGET OF Rapamycin DALAM EPILEPSI
- The efficacy of Rapamycin against the neuropathic pain for Fabry disease
- Preoperative application of combination of portal venous injection of donor spleen cells and intraperitoneal injection of Rapamycin prolongs the survival of …
- Anti-angiogenic effect of Rapamycin in mouse oxygen-induced retinopathy is mediated through suppression of HIF-1alpha/VEGF pathway
- Effects of Rapamycin on blood lipid metabolism in renal transplant recipients
- Short-term use of Rapamycin combined with Tregs prolongs mouse cardiac graft survival but attenuates recipient’s anti-tumor immunity
- Allogeneic Hair Transplantation with Enhanced Survival by Anti-ICAM-1 Antibody with Short-Term Rapamycin Treatment in Nonhuman Primates
- Important role for the mammalian‐target‐of‐Rapamycin (mTOR) in the collecting duct as a determinant of transporter/channel profile and function
- Insulinoma and Tuberous Sclerosis: A possible mechanistic target of Rapamycin (mTOR) pathway abnormality?
- Diagnostic significance of phosphoinositide 3-kinase and mammalian target of Rapamycin complex 1 in preeclampsia
- Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to Rapamycin through regulating phosphorylation of Akt in …
- Rapamycin Alleviated the Symptoms of Fat Embolism Syndrome by Modulating Autophagy in a Rat Model
- The Role of Mammalian Target of Rapamycin (mTOR) in a Mouse Model of Cerebral Palsy
- Effects of Rapamycin and deferoxamin on wound healing after ischemia and hypoxia
- Effect of Rapamycin and chloroquine on osteosarcoma
- Rapamycin prevents apoptosis of myocardial cells in heart failure rats through up-regulating Akt.
- Neurotoxicity of Paclitaxel and Rapamycin in Rat Model with Transient Blood-Brain Barrier Disruption
- The influence and significance of Rapamycin on cardiomyocyte autophagy level of early heart failure rat
- The effect of Rapamycin on autophagy in human corneal epithelial cells
- AB0421 Rapamycin reduces disease activity through restoring regulatory t cell numbers in patients with active refractory rheumatoid arthritis
- Mechanisms of Rapamycin inhibition on mTOR and Drug Design
- Mammalian Targets of Rapamycin Inhibitors: Temsirolimus and Everolimus
- The role of Nrf2 in the anti-cell senescence effect of Rapamycin
- Rapamycin preserves the chondrogenic phenotype and suppresses cartilage degrading and inflammatory processes in osteoarthritis
- Rapamycin reduced inhibition of Vγ1 γδ T cells towards Vγ4 γδ T cells through down-regulating IL-4
- Immunomodulatory Effects of Rapamycin in Xenogeneic Graft Versus Host Disease
- Congenital Hyperinsulinism; Effects of Rapamycin on Min6 Pancreatic β-Cell Line
- EFFECTS OF Rapamycin ON AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA IN REMISSION
- Rule-Based Modeling Project of Insulin-Like Growth Factor and Mechanistic Target of Rapamycin Signaling Network with Site-Specific Interactions
- Rapamycin as a Novel Therapeutic for Alzheimer’s Disease: Prevention Assessed Through Neuroimaging
- Adsorption of a tumor-associated antigen onto crystalized Rapamycin nanoparticles for combined immuno-and antitumor therapy
- S23 Evaluation of phosphorylated protein kinase b (akt) and mammalian target of Rapamycin (mTOR) expression in malignant pleural mesothelioma (mpm) and their …
- FK506 and Rapamycin Bioconjugation: A Proposal to Increase the Viability of Transplanted Pancreatic Islets
- Role of mammalian target of Rapamycin protein in oxidative stress-induced lung injury and pulmonary fibrosis in immature rats
- The Role of Rapamycin‐Insensitive mTOR Signaling in the Regulation of Muscle Protein Synthesis in a Rat Model of Resistance Exercise
- Protective Effect of Rapamycin against Mitochondrial Injury in an Aging Parkinson’s Disease Mouse Model
- Investigation of the clinical predictors of in-stent restenosis after Rapamycin-eluting coronary stent implantation
- Activation of phosphoinositide 3-kinase/Akt/mechanistic target of Rapamycin pathway and response to everolimus in endocrine receptor-positive metastatic …
- CIP2A can be a therapeutic target of Rapamycin in radioresistant head and neck cancer with P53 mutation
- Effect of Rapamycin on proliferation, apoptosis and cell cycles of high glucose-cultured rat glomerular mesangial cell
- Rapamycin Interacts with Nutrition to Decrease Basal Metabolic Rate of Drosophila melanogaster
- Regulatory effect of Rapamycin on key genes of circadian rhythm in senescent cells
- Antifibrotic effect of Rapamycin, an inhibitor of mTOR pathway, on the TGF-β2 induced proliferation of human tenon fibroblasts
- NBR1 and KIF14 Downstream of the Mammarian Target of Rapamycin Pathway Predict Recurrence in Nonmuscle Invasive Low Grade Urothelial Carcinoma …
- Expression of signaling pathway of mammalian target of Rapamycin in articular cartilage cell induced by interleukin 1β
- Improvement in Renal Cystic Disease of Tuberous Sclerosis Complex After Treatment with Mammalian Target of Rapamycin Inhibitor
- Abstract P340: Immunomodulatory Effect of Rapamycin on the Expression of Anti-inflammatory Cytokines in Npr1 Gene-deleted Mice
- Age-Specific Prolongation of Graft Survival in Recipients Treated With Rapamycin is Linked to CD4+ IFN-g+ IL-10+ Cells
- Establishment and Application of HPLC Method for Content Determination of Rapamycin in Human Monocyte THP-1 Derived Foam Cells
- Effects of Rapamycin preconditioning on lung injury induced by limb ischemia-reperfusion in rats
- The protective effect of Rapamycin on beta-amyloid protein 25-35-induced PC12 cells death
- Effect of Rapamycin treatment during postâ activation and/or in vitro culture on embryonic development after parthenogenesis and in vitro fertilization in pigs
- Therapeutic effect of edaravone combined with Rapamycin on neural injury in rats with subarachnoid hem-orrhage
- Rapamycin-Fortified Diet Delays Wound Repair, Alters CD4+ & γδ+ Splenocyte, CD3+ Thymocyte Distributions in Mice
- Toxic effect of Rapamycin in a young rat model of pentylenetetrazole-induced Kindling epilepsy
- Cell-intrinsic PD-L1 directs tumor initiating cell fate and Rapamycin and interferon-γ response
- Short-term Rapamycin persistently improves cardiac function after cessation of treatment in aged male and female mice.
- Combination of Rapamycin and crizotinib induces partial remission of pleural mesothelioma in a patient-derived xenograft model
- Mammalian Target Of Rapamycin Is A Key Molecule For Eosinophil Differentiation In Bone Marrow
- … communities of developing countries. In the national project entitled: TREATMENT OF BETA-THALASSEMIA PATIENTS WITH Rapamycin (SIROLIMUS): FROM PRE …
- Rapamycin suppresses ErbB2-overexpressing mammary tumors through selective inhibition of luminal progenitor cells and tumor-initiating cells
- 361 Focal adhesion kinase–mammalian target of Rapamycin pathway–mediated different proliferation, migration, and differentiation abilities of satellite cells in Lantang …
- Is phosphatidylinositol 3-kinase/AKT/mammalian target of Rapamycin pathway therapeutic target for esophageal adenocarcinoma
- Rapamycin-loaded nanoporous α-Fe₂O₃ as an endothelial favorable and thromboresistant coating for biodegradable drug-eluting Fe stent applications
- Identification of the mechanistic target of Rapamycin complex 2-associated interactome involved in brain cancer cell motility by affinity purification-mass spectrometry
- Advances in lack of amino acid-mediated autophagy via mammalian target of Rapamycin complex 1 signal pathway.
- Nicotine inhibits Rapamycin-induced hyperalgesia in na? ve mice via activating mTORC1/S6K/IRS-1-related feedback inhibition loop
- Autophagy-inducer Rapamycin alleviates malnutrition-associated liver steatosis: The role of autophagy in malnutrition induced liver damage
- The Analyses Of Alveolar Epithelial Injury Through The Lipid Metabolic Stress In The Mammalian Target Of Rapamycin Inhibitor Induced Lung Disease
- Abstract P209: Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Generates Reactive Oxygen Species in Mouse Endothelial Cells via NFkB …
- Study on the regulation of mammalian target of Rapamycin complex 1 (mTORC1) by nudix-type motif 2 (NUDT2) in cancer cells
- The Mammalian Target of Rapamycin and DNA methyltransferase 1 axis mediates vascular endothelial dysfunction in response to disturbed flow
- … Control Conventional T-Cells While Supporting Treg Reconstitution Post-Transplant: Long-Term GVHD-Free Survival by Combining OX40L Blockade with Rapamycin
- Induction of miR-302a by Rapamycin Protects Human Pluripotent Stem Cells Derived Cardiomyocytes Against Simulated Ischemia/Reoxygenation Injury Under …
- CALCINEURIN INHIBITOR WITHDRAWAL AND CONVERSION TO MAMMALIAN TARGET OF Rapamycin INHIBITOR (EVEROLIMUS) IN PEDIATRIC …
- … acid (M4N) broadly suppresses cancer metabolism and synergistically induces strong anticancer activity in combination with etoposide, Rapamycin and UCN-01
- … DRIVING FIBROSIS: The Analyses Of Alveolar Epithelial Injury Through The Lipid Metabolic Stress In The Mammalian Target Of Rapamycin Inhibitor Induced Lung …
- Statement of Retraction. A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet …
- Down‐Regulation of OATP1B1‐Mediated Transport by Mammalian Target of Rapamycin (mTOR) Inhibitors Everolimus and Sirolimus: Potential Mechanism and …
- B-cell activating factor involved in the pathogenesis of lupus nephritis through regulating phosphoino-sitide 3-kinase/protein kinase B/mammalian target of Rapamycin …
- … systemic lupus erythematosus is mainly associated with the decreased number of regulatory t cells and low-dose il-2 combined with Rapamycin can efficiently recovery …
- Correlation of metastasis associated gene-1 and mammalian target of Rapamycin expression with clinical pathology in rectal cancer
- Microrna-25 Binds To Tuberous Sclerosis Complex 1 To Modulate Airway Smooth Muscle Proliferation Via Mammalian Target Of Rapamycin Signaling Pathway
- MP06-07 CD4+IFN-γ+IL-10+ CELLS FACILITATE A PROLONGATION OF GRAFT SURVIVAL IN OLD RECIPIENT MICE TREATED WITH Rapamycin
- LSC-2017-RNA-Seq analysis reveals major differences between the effects of Rapamycin and dual mTORC1/2 inhibition during TGFß1-induced myofibroblast …
- P01. 31 Mammalian target of Rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death
- Expression of Phosphatidylinositol 3-Kinase, Protein Kinase B and Mammalian Target of Rapamycin in Substan-tia Nigra in Rats with Parkinson’s Disease
- The effects and regulation of the Wnt inhibitor Dickkopf-1 and the mechanistic target of Rapamycin in osteotropic cancers
- … Kinase Kinase Kinase Kinase-3 (MAP4K3) in Preterm Skeletal Muscle Satellite Cell Myogenesis and Mammalian Target of Rapamycin Complex 1 (mTORC1) …
- Immune tolerance to recombinant immunotoxin LMB-100 using synthetic vaccine particles encapsulating Rapamycin
- Induction of immune tolerance to recombinant immunotoxin LMB-100 using synthetic vaccine particles encapsulating Rapamycin
- The target of Rapamycin and mechanisms of cell growth
- Rapamycin and Alzheimer’s disease: time for a clinical trial?
- Rapamycin for longevity: opinion article
- Rapamycin activates mammalian microautophagy
- Rapamycin and Alzheimer disease: a double-edged sword?
- Rapamycin, proliferation and geroconversion to senescence
- Rapamycin-inspired macrocycles with new target specificity
- Recent discoveries on the role of TOR (Target of Rapamycin) signaling in translation in plants
- Rapamycin and treatment of venous malformations
- Mechanistic target of Rapamycin complex 1 and 2 in human temporal lobe epilepsy
- Cell cycle control by the target of Rapamycin signalling pathway in plants
- Rapamycin improves healthspan but not inflammaging in nfκb1−/− mice
- Rapamycin: a bacteria-derived immunosuppressant that has anti-atherosclerotic effects and its clinical application
- ETV7 is an essential component of a Rapamycin-insensitive mTOR complex in cancer
- The role of the mammalian target of Rapamycin (mTOR) in pulmonary fibrosis
- Target of Rapamycin signaling orchestrates growth–defense trade‐offs in plants
- Rapamycin for the aging skin
- Promising effect of Rapamycin on multiple sclerosis
- Rapamycin in ischemic stroke: Old drug, new tricks?
- Rapamycin‐insensitive mechanistic target of Rapamycin regulates basal and resistance exercise‐induced muscle protein synthesis
- Effect of caloric restriction and Rapamycin on ovarian aging in mice
- Mechanistic target of Rapamycin–independent antidepressant effects of (R)-ketamine in a social defeat stress model
- Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease
- A novel Rapamycin analog is highly selective for mTORC1 in vivo
- Effects of Rapamycin on growth hormone receptor knockout mice
- Rapamycin improves the neuroprotection effect of inhibition of NLRP3 inflammasome activation after TBI
- Comparison of folate-conjugated Rapamycin versus unconjugated Rapamycin in an orthologous mouse model of polycystic kidney disease
- Mechanistic target of Rapamycin (mTOR) pathway, focal cortical dysplasia and epilepsy
- Target of Rapamycin kinase: Central regulatory hub for plant growth and metabolism
- A Rapamycin-activated caspase 9-based suicide gene
- Fasting and Rapamycin: diabetes versus benevolent glucose intolerance
- Lung function response and side effects to Rapamycin for lymphangioleiomyomatosis: a prospective national cohort study
- A randomized control trial to establish the feasibility and safety of Rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive …
- Rapamycin protects against peritendinous fibrosis through activation of autophagy
- Rapamycin enhances mitophagy and attenuates apoptosis after spinal ischemia-reperfusion injury
- Protective effects of the mechanistic target of Rapamycin against excess iron and ferroptosis in cardiomyocytes
- Rapamycin inhibits proliferation and induces autophagy in human neuroblastoma cells
- Resistance exercise-induced hypertrophy: a potential role for Rapamycin-insensitive mTOR
- Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila
- Efficacy and safety of topical Rapamycin in patients with facial angiofibromas secondary to tuberous sclerosis complex: the TREATMENT randomized clinical trial
- Antigen-selective modulation of AAV immunogenicity with tolerogenic Rapamycin nanoparticles enables successful vector re-administration
- A Rapamycin-based GMP-compatible process for the isolation and expansion of regulatory T cells for clinical trials
- Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts
- Novel roles of mechanistic target of Rapamycin signaling in regulating fetal growth
- Rapamycin treatment for amyotrophic lateral sclerosis: Protocol for a phase II randomized, double-blind, placebo-controlled, multicenter, clinical trial (RAP …
- Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis
- Topical Rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial
- Combination of melatonin and Rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis …
- Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis
- Rapamycin protects aging muscle
- Rapamycin improves insulin resistance and hepatic steatosis in type 2 diabetes rats through activation of autophagy
- inhibition of mTOR signaling and clinical activity of Rapamycin in head and neck cancer in a window of opportunity trial
- Multiple critical periods for Rapamycin treatment to correct structural defects in Tsc-1-suppressed brain
- Mammalian target of Rapamycin as a therapeutic target in osteoporosis
- Transcriptional and epigenetic regulation by the mechanistic target of Rapamycin complex 1 pathway
- Rapamycin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting IL-1β and IL-18 production
- Efficacy of Rapamycin in modulating autophagic activity of Botrytis cinerea for controlling gray mold
- Target of Rapamycin inhibition in Chlamydomonas reinhardtii triggers de novo amino acid synthesis by enhancing nitrogen assimilation
- Intranasal Rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome
- Mutations in PI3K110δ cause impaired natural killer cell function partially rescued by Rapamycin treatment
- Target of Rapamycin, a master regulator of multiple signalling pathways and a potential candidate gene for crop improvement
- Effects of Rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo—in search of potential anti-epileptogenic strategies for temporal …
- Oncogenic signalling through mechanistic target of Rapamycin (mTOR): A driver of metabolic transformation and cancer progression
- Effects of Rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero
- Negative effects of chronic Rapamycin treatment on behavior in a mouse model of fragile X syndrome
- Long term Rapamycin treatment improves mitochondrial DNA quality in aging mice
- Mechanistic target of Rapamycin (mTOR) signaling in status epilepticus
- Functional characterization of target of Rapamycin signaling in Verticillium dahliae
- Targeting mTOR with MLN0128 overcomes Rapamycin and chemoresistant primary effusion lymphoma
- Does Rapamycin slow down time?
- Mechanistic/mammalian target of Rapamycin: recent pathological aspects and inhibitors
- Mechanistic target of Rapamycin complex 1 signaling modulates vascular endothelial function through reactive oxygen species
- E-selectin targeted immunoliposomes for Rapamycin delivery to activated endothelial cells
- Metformin reduces glucose intolerance caused by Rapamycin treatment in genetically heterogeneous female mice
- Topical use of mammalian target of Rapamycin inhibitors in dermatology: A systematic review with meta-analysis
- Therapeutic control of leishmaniasis by inhibitors of the mammalian target of Rapamycin
- Multifunctional platinum@ BSA–Rapamycin nanocarriers for the combinatorial therapy of cerebral cavernous malformation
- Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR
- Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation
- Effect of mycophenolate and Rapamycin on renal fibrosis in lupus nephritis
- Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival
- Neuroprotective effects of Rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling
- Therapeutic activation of autophagy by combined treatment with Rapamycin and trehalose in a mouse MPTP-induced model of Parkinson’s disease
- Rapalogs potential as practical alternatives to Rapamycin
- Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by Rapamycin
- Nanoparticle ferritin-bound erastin and Rapamycin: a nanodrug combining autophagy and ferroptosis for anticancer therapy
- Repeated systemic treatment with Rapamycin affects behavior and amygdala protein expression in rats
- Sleep-deprived cognitive impairment in aging mice is alleviated by Rapamycin
- Rapamycin attenuates mitochondrial injury and renal tubular cell apoptosis in experimental contrast-induced acute kidney injury in rats
- Metformin synergizes with Rapamycin to inhibit the growth of pancreatic cancer in vitro and in vivo
- Hyaluronate/lactoferrin layer-by-layer-coated lipid nanocarriers for targeted co-delivery of Rapamycin and berberine to lung carcinoma
- Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats
- Target of Rapamycin (TOR) regulates the expression of lncRNAs in response to abiotic stresses in cotton
- Rapamycin increases collateral circulation in rodent brain after focal ischemia as detected by multiple modality dynamic imaging
- Rapamycin is not protective against ischemic and cisplatin-induced kidney injury
- Target of Rapamycin inhibitors (TOR‐I; sirolimus and everolimus) for primary immunosuppression in kidney transplant recipients
- Significance and mechanism of androgen receptor overexpression and androgen receptor/mechanistic target of Rapamycin cross‐talk in hepatocellular carcinoma
- Regulation of dendritic cell immune function and metabolism by cellular nutrient sensor mammalian target of Rapamycin (mTOR)
- The target of Rapamycin kinase affects biomass accumulation and cell cycle progression by altering carbon/nitrogen balance in synchronized Chlamydomonas …
- Disease evolution and response to Rapamycin in activated phosphoinositide 3-kinase δ syndrome: the european society for immunodeficiencies-activated …
- Rapamycin as an adjunctive therapy for NLRC4 associated macrophage activation syndrome
- Rapamycin prevents thoracic aortic aneurysm and dissection in mice
- Caloric restriction and Rapamycin differentially alter energy metabolism in yeast
- Investigating the effect of target of Rapamycin kinase inhibition on the Chlamydomonas reinhardtii phosphoproteome: from known homologs to new targets
- Outcomes associated with mammalian target of Rapamycin (mTOR) inhibitors in heart transplant recipients: A meta-analysis
- The use of Rapamycin in patients with tuberous sclerosis complex: Long-term results
- Discovery of novel dual histone deacetylase and mammalian target of Rapamycin target inhibitors as a promising strategy for cancer therapy
- Self-assembled amphiphilic zein-lactoferrin micelles for tumor targeted co-delivery of Rapamycin and wogonin to breast cancer
- Advanced glycation end‐products suppress autophagic flux in podocytes by activating mammalian target of Rapamycin and inhibiting nuclear translocation of …
- Rapamycin rescues age-related changes in muscle-derived stem/progenitor cells from progeroid mice
- Farnesyltransferase inhibitor and Rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson–Gilford progeria …
- Platelet membrane-coated nanoparticle-mediated targeting delivery of Rapamycin blocks atherosclerotic plaque development and stabilizes plaque in apolipoprotein …
- Combined treatment with doxorubicin and Rapamycin is effective against in vitro and in vivo models of human glioblastoma
- Mammalian target of Rapamycin inhibition attenuates myocardial ischaemia–reperfusion injury in hypertrophic heart
- Rapamycin for refractory discoid lupus erythematosus
- Anti-fibrotic effects of pirfenidone and Rapamycin in primary IPF fibroblasts and human alveolar epithelial cells
- Use of topical Rapamycin in the treatment of superficial lymphatic malformations
- Hybrid electrospun Rapamycin-loaded small-diameter decellularized vascular grafts effectively inhibit intimal hyperplasia
- Efficacy and safety of mTOR inhibitors (Rapamycin and its analogues) for tuberous sclerosis complex: a meta-analysis
- Rapamycin prevents surgery-induced immune dysfunction in patients with bladder cancer
- Rapamycin-induced autophagy protects proximal tubular renal cells against proteinuric damage through the transcriptional activation of the nerve growth factor …
- Synthesis and application of light-switchable arylazopyrazole Rapamycin analogs
- Phase II Study of BEZ235 versus Everolimus in Patients with Mammalian Target of Rapamycin Inhibitor‐Naïve Advanced Pancreatic Neuroendocrine Tumors
- Mood-stabilizing effects of Rapamycin and its analog temsirolimus: relevance to autophagy
- Target of Rapamycin complex 2–dependent phosphorylation of the coat protein Pan1 by Akl1 controls endocytosis dynamics in Saccharomyces cerevisiae
- Investigation of novel regulation of N-myristoyltransferase by mammalian target of Rapamycin in breast cancer cells
- Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to Rapamycin
- Mechanistic target of Rapamycin inhibitors: successes and challenges as cancer therapeutics
- Dual roles of mammalian target of Rapamycin in regulating liver injury and tumorigenesis in autophagy‐defective mouse liver
- Rapamycin protects skin fibroblasts from ultraviolet B-induced photoaging by suppressing the production of reactive oxygen species
- Effects of Rapamycin on the mechanistic target of Rapamycin (mTOR) pathway and telomerase in breast cancer cells
- Ponatinib combined with Rapamycin causes regression of murine venous malformation
- Restoration of aberrant mTOR signaling by intranasal Rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down …
- Rapamycin for lymphangioleiomyomatosis: optimal timing and optimal dosage
- Rapamycin removes damaged mitochondria and protects human trabecular meshwork (TM-1) cells from chronic oxidative stress
- Rapamycin mitigates erythrocyte membrane transport functions and oxidative stress during aging in rats
- Estimating the concentration of therapeutic range using disease-specific iPS cells: low-dose Rapamycin therapy for Pendred syndrome
- Comparative transcriptomic profile of tolerogenic dendritic cells differentiated with vitamin D3, dexamethasone and Rapamycin
- A binding site hotspot map of the fkbp12–Rapamycin–frb ternary complex by photoaffinity labeling and mass spectrometry-based proteomics
- Protective effect of Rapamycin on endothelial-to-mesenchymal transition in HUVECs through the Notch signaling pathway
- Mammalian target of Rapamycin at the crossroad between Alzheimer’s disease and diabetes
- … stem cells protect against hypoxia‐ischemia brain damage by enhancing autophagy through brain derived neurotrophic factor/mammalin target of Rapamycin …
- Mammalian target of Rapamycin inhibition in Trypanosoma cruzi-infected macrophages leads to an intracellular profile that is detrimental for infection
- Saccharomyces cerevisiae adapted to grow in the presence of low-dose Rapamycin exhibit altered amino acid metabolism
- Rapamycin attenuates high glucose-induced inflammation through modulation of mTOR/NF-κB pathways in macrophages
- The mechanistic target of Rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders
- Rapamycin reduces podocyte apoptosis and is involved in autophagy and mTOR/P70S6K/4EBP1 signaling
- inhibition of mTOR by Rapamycin Aggravates Corneal Epithelial Stem Cell Deficiency by Upregulating Inflammatory Response
- Rapamycin‑induced miR‑30a downregulation inhibits senescence of VSMCs by targeting Beclin1
- The impairments of α-synuclein and mechanistic target of Rapamycin in rotenone-induced SH-SY5Y cells and mice model of Parkinson’s disease
- Berunda polypeptides: biheaded Rapamycin carriers for subcutaneous treatment of autoimmune dry eye disease
- Rapamycin confers neuroprotection against aging-induced oxidative stress, mitochondrial dysfunction, and neurodegeneration in old rats through activation of …
- Antileishmanial effect of Rapamycin as an alternative approach to control Leishmania tropica infection
- Reduced menin expression impairs Rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration
- Rapamycin modulates glucocorticoid receptor function, blocks atrophogene REDD1, and protects skin from steroid atrophy
- Depletion of NBR1 in urothelial carcinoma cells enhances Rapamycin‐induced apoptosis through impaired autophagy and mitochondrial dysfunction
- The effect of Rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies
- Endoplasmic reticulum stress-induced apoptosis in intestinal epithelial cells: a feed-back regulation by mechanistic target of Rapamycin complex 1 (mTORC1)
- Intravesical delivery of Rapamycin via folate-modified liposomes dispersed in thermo-reversible hydrogel
- A Perfect sTORm: the role of the mammalian target of Rapamycin (mTOR) in cerebrovascular dysfunction of alzheimer’s disease: a mini-review
- Rapamycin relieves inflammation of experimental autoimmune encephalomyelitis by altering the balance of Treg/Th17 in a mouse model
- … of cardiac miRNA Transcriptomes induced by diabetes and Rapamycin treatment and identification of a Rapamycin-associated cardiac MicroRNA signature
- Behavioral conditioning of anti-proliferative and immunosuppressive properties of the mTOR inhibitor Rapamycin
- Therapeutic suppression of mTOR (mammalian target of Rapamycin) signaling prevents and reverses salt-induced hypertension and kidney injury in dahl salt-sensitive …
- Enhanced supply of methionine or arginine alters mechanistic target of Rapamycin signaling proteins, messenger RNA, and microRNA abundance in heat …
- New mammalian target of Rapamycin (mTOR) modulators derived from natural product databases and marine extracts by using molecular docking techniques
- Hypervascularization in mTOR‐dependent focal and global cortical malformations displays differential Rapamycin sensitivity
- Acute and chronic Rapamycin use in patients with fibrodysplasia ossificans progressiva: a report of two cases
- Melatonin and Rapamycin attenuate isoflurane-induced cognitive impairment through inhibition of neuroinflammation by suppressing the mTOR signaling in …
- Intracellular delivery of Rapamycin from FKBP elastin-like polypeptides is consistent with macropinocytosis
- The regulation of Rapamycin in planarian Dugesia japonica Ichikawa & Kawakatsu, 1964 regeneration according to TOR signaling pathway
- Liraglutide ameliorates cognitive decline by promoting autophagy via the AMP-activated protein kinase/mammalian target of Rapamycin pathway in a streptozotocin …
- Rapamycin, an immunosuppressant and mTORC1 inhibitor, triples the antidepressant response rate of ketamine at 2 weeks following treatment: a double-blind …
- Combined ischemic and Rapamycin preconditioning alleviated liver ischemia and reperfusion injury by restoring autophagy in aged mice
- … maintaining the ratios of Thr: Phe, Lys: Thr, Lys: His, and Lys: Val alters mammary cellular metabolites, mammalian target of Rapamycin signaling, and gene …
- Target of Rapamycin‐signaling modulates starch accumulation via glycogenin phosphorylation status in the unicellular red alga Cyanidioschyzon merolae
- Metformin ameliorates experimental diabetic periodontitis independently of mammalian target of Rapamycin (mTOR) inhibition by reducing NIMA‐related kinase 7 …
- Rapamycin Induced Autophagy Inhibits Inflammation‐Mediated Endplate Degeneration by Enhancing Nrf2/Keap1 Signaling of Cartilage Endplate Stem Cells
- Local release of Rapamycin by microparticles delays islet rejection within the anterior chamber of the eye
- High glucose-induced podocyte injury involves activation of mammalian target of Rapamycin (mTOR)-induced endoplasmic reticulum (ER) stress
- Hippocampal mammalian target of Rapamycin is implicated in stress-coping behavior induced by cannabidiol in the forced swim test
- Label-free single-molecule quantification of Rapamycin-induced FKBP–FRB dimerization for direct control of cellular mechanotransduction
- Rapamycin-loaded polysorbate 80-coated PLGA nanoparticles: Optimization of formulation variables and in vitro anti-glioma assessment
- Synergistic clearance of intracellular pathogens by hyaluronan-streptomycin micelles encapsulated with Rapamycin
- Protective effect of a mechanistic target of Rapamycin inhibitor on an in vivo model of cisplatin-induced ovarian gonadotoxicity
- Layer-by-layer gelatin/chondroitin quantum dots-based nanotheranostics: combined Rapamycin/celecoxib delivery and cancer imaging
- Rapamycin for inclusion body myositis: targeting non-inflammatory mechanisms
- Role of mammalian target of Rapamycin in atherosclerosis
- Rapamycin mediates mTOR signaling in reactive astrocytes and reduces retinal ganglion cell loss
- Cardioprotective effects of dietary Rapamycin on adult female C57BLKS/J-Leprdb mice
- Blockade of Treg cell differentiation and function by the interleukin‐21–mechanistic target of Rapamycin axis via suppression of autophagy in patients with systemic …
- Rapamycin attenuates Tc1 and Tc17 cell responses in cigarette smoke-induced emphysema in mice
- Mammalian target of Rapamycin inhibitors combined with calcineurin inhibitors as initial immunosuppression in renal transplantation: a meta-analysis
- Differential effects of Rapamycin on Bursaphelenchus xylophilus with different virulence and differential expression of autophagy genes under stresses in nematodes
- Impacting dementia and cognitive loss with innovative strategies: mechanistic target of Rapamycin, clock genes, circular non-coding ribonucleic acids, and …
- Rapamycin Supplementation May Ameliorate Erectile Function in Rats With Streptozotocin–Induced Type 1 Diabetes by Inducing Autophagy and Inhibiting Apoptosis …
- Glycol Chitosan-Docosahexaenoic Acid Liposomes for Drug Delivery: Synergistic Effect of Doxorubicin-Rapamycin in Drug-Resistant Breast Cancer
- Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by Rapamycin ameliorates pathology in an Alzheimer’s disease model
- Preconditioning of umbilical cord‐derived mesenchymal stem cells by Rapamycin increases cell migration and ameliorates liver ischaemia/reperfusion injury in mice …
- Rapamycin and fingolimod modulate Treg/Th17 cells in experimental autoimmune encephalomyelitis by regulating the Akt-mTOR and MAPK/ERK pathways
- Rapamycin loaded TPGS-Lecithins-Zein nanoparticles based on core-shell structure for oral drug administration
- A study on the mechanism of Rapamycin mediating the sensitivity of pancreatic cancer cells to cisplatin through PI3K/AKT/mTOR signaling pathway
- Transcriptome of white shrimp Litopenaeus vannamei induced with Rapamycin reveals the role of autophagy in shrimp immunity
- … supply during the periparturient period enhances insulin signaling, amino acid transporters, and mechanistic target of Rapamycin pathway proteins in adipose …
- Rapamycin synergizes with cisplatin in antiendometrial cancer activation by improving il-27–stimulated cytotoxicity of nk cells
- Cinobufagin suppresses colorectal cancer angiogenesis by disrupting the endothelial mammalian target of Rapamycin/hypoxia‐inducible factor 1α axis
- Rapamycin upregulates connective tissue growth factor expression in hepatic progenitor cells through TGF-β-Smad2 dependent signaling
- Rapamycin induces autophagy to alleviate acute kidney injury following cerebral ischemia and reperfusion via the mTORC1/ATG13/ULK1 signaling pathway
- Metabolic shift induced by ω-3 PUFAs and Rapamycin lead to cancer cell death
- Mammalian target of Rapamycin complex 2 (mTORC2) controls glycolytic gene expression by regulating Histone H3 Lysine 56 acetylation
- Rapamycin enhances growth inhibition on urothelial carcinoma cells through LKB1 deficiency‐mediated mitochondrial dysregulation
- Mechanistic target of Rapamycin complex 1 promotes the expression of genes encoding electron transport chain proteins and stimulates oxidative …
- … stress affects muscle hypertrophy, muscle protein synthesis and uptake of amino acid in broilers via insulin like growth factor-mammalian target of Rapamycin …
- Mammalian target of Rapamycin complex 1 signaling is required for the dedifferentiation from biliary cell to bipotential progenitor cell in zebrafish liver regeneration
- Melatonin protects against streptozotocin-induced diabetic cardiomyopathy through the mammalian target of Rapamycin (mTOR) signaling pathway
- Self-assembled amphiphilic-dextran nanomicelles for delivery of Rapamycin
- Controversies on the potential therapeutic use of Rapamycin for treating a lysosomal cholesterol storage disease
- Involvement of pro-inflammation signal pathway in inhibitory effects of Rapamycin on oxaliplatin-induced neuropathic pain
- Direct targeting of the mTOR (mammalian target of Rapamycin) kinase improves endothelial permeability in drug-eluting stents—brief report
- … , a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of Rapamycin …
- Oligo (lactic acid) 8-Rapamycin prodrug-loaded poly (ethylene glycol)-block-poly (lactic acid) micelles for injection
- New metformin derivative HL 156A prevents oral cancer progression by inhibiting the insulin‐like growth factor/AKT/mammalian target of Rapamycin pathways
- Mammalian target of Rapamycin complex 1 and its downstream effector collapsin response mediator protein‐2 drive reinstatement of alcohol reward seeking
- Lysosome membrane permeabilization and disruption of the molecular target of Rapamycin (mTOR)-lysosome interaction are associated with the inhibition of lung …
- Effects of mammalian target of Rapamycin on proliferation, apoptosis and differentiation of myoblasts undergoing mechanical stress
- Low dose of IL-2 combined with Rapamycin restores and maintains the long-term balance of Th17/Treg cells in refractory SLE patients
- Amino acids stimulate glycyl‐tRNA synthetase nuclear localization for mammalian target of Rapamycin expression in bovine mammary epithelial cells
- Sodium fluoride induces splenocyte autophagy via the mammalian targets of Rapamycin (mTOR) signaling pathway in growing mice
- Role of mammalian target of Rapamycin in regulating HIF-1α and vascular endothelial growth factor signals in glaucoma
- Glucosamine promotes osteoblast proliferation by modulating autophagy via the mammalian target of Rapamycin pathway
- Rapamycin inhibits ox-LDL-induced inflammation in human endothelial cells in vitro by inhibiting the mTORC2/PKC/c-Fos pathway
- Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway
- … acids affect jejunal cell proliferation and functions by affecting antioxidant capacity, Wnt/β-catenin, and the mechanistic target of Rapamycin signaling pathways in …
- Mammalian target of Rapamycin 2 (mTOR2) and C-MYC modulate glucosamine-6-phosphate synthesis in glioblastoma (GBM) cells through glutamine: fructose-6 …
- Rapamycin inhibits activation of AMPK-mTOR signaling pathway-induced Alzheimer’s disease lesion in hippocampus of rats with type 2 diabetes mellitus
- The protective effects of Rapamycin on cell autophagy in the renal tissues of rats with diabetic nephropathy via mTOR-S6K1-LC3II signaling pathway
- Rapamycin alleviates proinflammatory cytokines and nociceptive behavior induced by chemotherapeutic paclitaxel
- … neonatal hypoxic brain injury by reducing oxidative stress and activation of phosphatidylinositol-3-kinase/Akt/mammalian target of Rapamycin (PI3K/Akt/mTOR …
- Synthesis and biological evaluation of Rapamycin-derived, next generation small molecules
- Rapamycin relieves anxious emotion and synaptic plasticity deficits induced by hindlimb unloading in mice
- Rapamycin inhibits peritoneal fibrosis by modifying lipid homeostasis in the peritoneum
- Rapamycin prevents the intervertebral disc degeneration via inhibiting differentiation and senescence of annulus fibrosus cells
- Rapamycin combined with α-Cyanoacrylate contributes to inhibiting intimal hyperplasia in rat models
- Crocin induces anti-ischemia in middle cerebral artery occlusion rats and inhibits autophagy by regulating the mammalian target of Rapamycin
- Haploinsufficiency of mechanistic target of Rapamycin ameliorates bag3 cardiomyopathy in adult zebrafish
- … -mediated apoptosis in renal cell carcinoma via the p53/AMP‑activated protein kinase/mammalian target of Rapamycin autophagy signaling pathway
- Mammalian target of Rapamycin signaling and ubiquitin-proteasome–related gene expression in skeletal muscle of dairy cows with high or normal body …
- p53 induces miR‐199a‐3p to suppress mechanistic target of Rapamycin activation in cisplatin‐induced acute kidney injury
- … -protective role of metformin in patients with acute stroke and type 2 diabetes mellitus via AMPK/mammalian target of Rapamycin (mTOR) signaling pathway …
- Rapamycin modulate Treg/Th17 balance via regulating metabolic pathways: a study in mice
- Stomatitis associated with mammalian target of Rapamycin inhibition: a review of pathogenesis, prevention, treatment, and clinical implications for oral practice in …
- Proteomic mapping by Rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane
- Feedback activation of SGK3 and AKT contributes to Rapamycin resistance by reactivating mTORC1/4EBP1 axis via TSC2 in breast cancer
- The change of immunosuppressive regimen from calcineurin inhibitors to mammalian target of Rapamycin (mTOR) inhibitors and its effect on malignancy following …
- Rapamycin attenuates BAFF‐extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B‐lymphoid cells
- mTOR inhibitor Rapamycin induce polymorphonuclear myeloid-derived suppressor cells mobilization and function in protecting against acute graft-versus-host disease …
- Effect of Rapamycin on bone mass and strength in the α2 (I)‐G610C mouse model of osteogenesis imperfecta
- A novel therapeutic approach to colorectal cancer in diabetes: role of metformin and Rapamycin
- Mammalian target of Rapamycin (mTOR) and the proteasome attenuates IL-1β expression in primary mouse cardiac fibroblasts
- A Rapamycin derivative, biolimus, preferentially activates autophagy in vascular smooth muscle cells
- Investigating effect of Rapamycin and metformin on angiogenesis in hepatocellular carcinoma cell line
- Sirolimus (Rapamycin) for the targeted treatment of the fibrotic sequelae of Graves’ orbitopathy
- Rapamycin nano-micelle ophthalmic solution reduces corneal allograft rejection by potentiating myeloid-derived suppressor cells’ function
- Targeting the phosphatidylinositol 3‐kinase/Akt/mechanistic target of Rapamycin signaling pathway in B‐lineage acute lymphoblastic leukemia: An update
- Comprehensive analysis of lysine acetylome reveals a site-specific pattern in Rapamycin-induced autophagy
- Rapamycin suppresses postnatal muscle hypertrophy induced by myostatin-inhibition accompanied by transcriptional suppression of the Akt/mTOR pathway
- Targeting delivery of Rapamycin with anti-collagen IV peptide conjugated Fe3O4@ nanogels system for vascular restenosis therapy
- Involvement of phosphatidylinositol-3 kinase/Akt/mammalian target of Rapamycin/peroxisome proliferator-activated receptor γ pathway for induction and maintenance …
- MiR‐99a‐5p inhibits bladder cancer cell proliferation by directly targeting mammalian target of Rapamycin and predicts patient survival
- T-2 Toxin Exposure Induces Apoptosis in TM3 Cells by Inhibiting Mammalian Target of Rapamycin/Serine/Threonine Protein Kinase (mTORC2/AKT) to Promote Ca2+ …
- Targeting the mammalian target of Rapamycin for epileptic encephalopathies and malformations of cortical development
- … the levels of autophagy-related genes via adenosine 5′-monophosphate-activated protein kinase/mammalian target of Rapamycin signaling pathway in …
- Chronic oral Rapamycin decreases adiposity, hepatic triglycerides and insulin resistance in male mice fed a diet high in sucrose and saturated fat
- The sources of essential fatty acids for allergic and cancer patients; a connection with insight into mammalian target of Rapamycin: A narrative review
- Challenging the CNS targeting potential of systemically administered nanoemulsion delivery systems: a case study with Rapamycin-containing fish oil nanoemulsions …
- Rapamycin inhibited photoreceptor necroptosis and protected the retina by activation of autophagy in experimental retinal detachment
- Renal toxicity with mammalian target of Rapamycin inhibitors: A meta-analysis of randomized clinical trials
- Organ preservation with targeted Rapamycin nanoparticles: a pre-treatment strategy preventing chronic rejection in vivo
- Effect of Rapamycin microspheres in Sjögren syndrome dry eye: preparation and outcomes
- Blocking mammalian target of Rapamycin (mTOR) alleviates neuropathic pain induced by chemotherapeutic bortezomib
- Rapamycin-mediated mTOR inhibition impairs silencing of sex chromosomes and the pachytene piRNA pathway in the mouse testis
- … oxygen species (ROS) production, and inhibition of cell migration and nuclear factor kappa B (Nf-κB)/mammalian target of Rapamycin (m-TOR) signalling …
- Rapamycin corrects T regulatory cell depletion and improves embryo implantation and live birth rates in a murine model
- The effect of the mTOR inhibitor Rapamycin on glucoCEST signal in a preclinical model of glioblastoma
- Neolymphostin A is a covalent phosphoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) dual inhibitor that employs an unusual electrophilic …
- Nicotine inhibits Rapamycin-induced pain through activating mTORC1/S6K/IRS-1-related feedback inhibition loop
- The local mammalian target of Rapamycin (mTOR) modulation: a promising strategy to counteract neurodegeneration
- Regulation of YAP by Mammalian Target of Rapamycin Complex 1 in Endothelial Cells Controls Blood Pressure Through COX-2/mPGES-1/PGE2 Cascade
- Long‐term treatment with the mTOR inhibitor Rapamycin has minor effect on clinical laboratory markers in middle‐aged marmosets
- Androgens induce growth of the limb skeletal muscles in a Rapamycin-insensitive manner
- Rapamycin improves bone mass in high-turnover osteoporosis with iron accumulation through positive effects on osteogenesis and angiogenesis
- Synergistic effect of Rapamycin and metformin against germ cell apoptosis and oxidative stress after testicular torsion/detorsion-induced ischemia/reperfusion …
- Effect and molecular mechanism of mTOR inhibitor Rapamycin on temozolomide‑induced autophagic death of U251 glioma cells
- Clinical significance of chemokine receptor CXCR4 and mammalian target of Rapamycin (mTOR) expression in patients with diffuse large B-cell lymphoma
- Curcumin inhibits the growth of liver cancer stem cells through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of Rapamycin signaling …
- Delivery of Rapamycin using in situ forming implants promotes immunoregulation and vascularized composite allograft survival
- Rapamycin protects spiral ganglion neurons from gentamicin-induced degeneration in vitro
- Rapamycin may inhibit murine S180 sarcoma growth by regulating the pathways associated with autophagy and cancer stem cells
- Rapamycin ameliorates immune-mediated aplastic anemia by inhibiting the proliferation and metabolism of T cells
- Rapamycin attenuates liver injury caused by vinyl chloride metabolite chloroethanol and lipopolysaccharide in mice
- Plk1-mediated phosphorylation of TSC1 enhances the efficacy of Rapamycin
- Characterization of female germline stem cells from adult mouse ovaries and the role of Rapamycin on them
- Rapamycin suppresses angiogenesis and lymphangiogenesis in melanoma by downregulating VEGF-A/VEGFR-2 and VEGF-C/VEGFR-3 expression
- Antitumor effect of sorafenib and mammalian target of Rapamycin inhibitor in liver transplantation recipients with hepatocellular carcinoma recurrence
- The Slt2-MAPK pathway is involved in the mechanism by which target of Rapamycin regulates cell wall components in Ganoderma lucidum
- … to lysine while maintaining an ideal ratio of lysine: methionine alters mammary cellular metabolites, mammalian target of Rapamycin signaling, and gene …
- Dissecting the Biological Effects of Isoflurane through the Mechanistic Target of Rapamycin (mTOR) and microRNAs (miRNAs)
- Is Rapamycin a rapalog?
- Global gene expression of histologically normal primary skin cells from BCNS subjects reveals “single-hit” effects that are influenced by Rapamycin
- The checkpoint kinase TOR (target of Rapamycin) regulates expression of a nuclear‐encoded chloroplast RelA‐SpoT homolog (RSH) and modulates chloroplast …
- Multifarious biologic loaded liposomes that stimulate the mammalian target of Rapamycin signaling pathway show retina neuroprotection after retina damage
- … Carcinoma Tumorigenesis Through Regulating Adenosine‐Monophosphate–Activated Protein Kinase Alpha/Mammalian Target of Rapamycin Axis in Mice
- Rapamycin attenuates articular cartilage degeneration by inhibiting β-catenin in a murine model of osteoarthritis
- Mechanistic target of Rapamycin inhibition with Rapamycin induces autophagy and correlative regulation in white shrimp (Litopenaeus vannamei)
- Targeting cellular metabolism using Rapamycin and/or doxycycline enhances anti-tumour effects in human glioma cells
- Rapamycin activates TGF receptor independently of its ligand: implications for endothelial dysfunction
- Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the TLR4/MyD88/NF‑κB signaling pathway
- Methionine and valine activate the mammalian target of Rapamycin complex 1 pathway through heterodimeric amino acid taste receptor (TAS1R1/TAS1R3) …
- Response to Rapamycin analogs but not PD-1 inhibitors in PTEN-mutated metastatic non-small-cell lung cancer with high tumor mutational burden
- Aldosterone modulates the mechanistic target of Rapamycin signaling in male mice
- Mammalian target of Rapamycin: is it relevant to COPD pathogenesis or treatment?
- Testicular injury attenuated by Rapamycin through induction of autophagy and inhibition of endoplasmic reticulum stress in streptozotocin-induced diabetic rats
- Eukaryotic Initiation Factor 4E (eIF4E) sequestration mediates 4E-BP1 response to Rapamycin
- … carcinoma cell proliferation and migration by inactivating phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of Rapamycin (mTOR) signaling pathway
- Akt Serine/Threonine Kinase 1 Regulates de Novo Fatty Acid Synthesis through the Mammalian Target of Rapamycin/Sterol Regulatory Element Binding Protein 1 …
- … the synthesis of pancreatic enzymes via the activation of mRNA expression and phosphorylation in the mammalian target of Rapamycin signalling pathways in …
- Rapamycin as a potential treatment for succinate dehydrogenase deficiency
- Rapamycin treatment increases hippocampal cell viability in an mTOR-independent manner during exposure to hypoxia mimetic, cobalt chloride
- Effect of acute aerobic exercise and Rapamycin treatment on autophagy in peripheral blood mononuclear cells of adults with prediabetes
- Everolimus, a mammalian target of Rapamycin inhibitor, ameliorated streptozotocin-induced learning and memory deficits via neurochemical alterations in …
- Use of mammalian target of Rapamycin inhibitors in patient with autosomal dominant polycystic kidney disease: an updated meta-analysis
- Curcumin‑induced promoter hypermethylation of the mammalian target of Rapamycin gene in multiple myeloma cells
- A subgroup of pleural mesothelioma expresses ALK protein and may be targetable by combined Rapamycin and crizotinib therapy
- Rapamycin treatment attenuates angiotensin II-induced abdominal aortic aneurysm formation via VSMC phenotypic modulation and down-regulation of ERK1/2 …
- Addition of the mammalian target of Rapamycin inhibitor, everolimus, to consolidation therapy in acute myeloid leukemia: experience from the UK NCRI AML17 …
- Critical role of mammalian target of Rapamycin for IL-10 dendritic cell induction by a flagellin A conjugate in preventing allergic sensitization
- Synergistic antitumour effects of Rapamycin and oncolytic reovirus
- The contribution of non-essential Schizosaccharomyces pombe genes to fitness in response to altered nutrient supply and target of Rapamycin activity
- The plant target of Rapamycin kinase: a connecTOR between sulfur and growth
- Graded replacing fishmeal with canola meal in diets affects growth and target of Rapamycin pathway gene expression of juvenile blunt snout bream, Megalobrama …
- Mechanistic target of Rapamycin (mTOR) protein expression in the tumor and its microenvironment correlates with more aggressive pathology at cystectomy
- “Tandem” Nanomedicine Approach against Osteoclastogenesis: Polysulfide Micelles Synergically Scavenge ROS and Release Rapamycin
- … effects on human pancreatic cancer cells by triggering cell cycle arrest, apoptosis, and modulation of AKT/mammalian target of Rapamycin (mTOR) and signal …
- Negative feedback loop of autophagy and endoplasmic reticulum stress in Rapamycin protection against renal ischemia‐reperfusion injury during initial reperfusion …
- Functional effects of cuprizone-induced demyelination in the presence of the mTOR-inhibitor Rapamycin
- Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β …
- … cell activation and liver fibrosis through modulation of intracellular ATP levels and the liver kinase B1/AMP-activated protein kinase/mammalian target of Rapamycin …
- Fluorofenidone inhibits UV‐A induced senescence in human dermal fibroblasts via the mammalian target of Rapamycin‐dependent SIRT1 pathway
- Rapamycin-and starvation-induced autophagy are associated with miRNA dysregulation in A549 cells
- The antidiabetic drug lobeglitazone protects mice from lipogenesis-induced liver injury via mechanistic target of Rapamycin complex 1 inhibition
- Protective effects of Rapamycin induced autophagy on CLP septic mice
- Searching for potential mTOR inhibitors: Ligand-based drug design, docking and molecular dynamics studies of Rapamycin binding site
- Preclinical evidence of the enhanced effectiveness of combined Rapamycin and AICAR in reducing kidney cancer
- Chloroquine Enhances Rapamycin-induced Apoptosis in MG63 Cells
- Rapamycin promotes the anticancer action of dihydroartemisinin in breast cancer MDA-MB-231 cells by regulating expression of Atg7 and DAPK
- Takeda G protein-coupled receptor 5-mechanistic target of Rapamycin complex 1 signaling contributes to the increment of glucagon-like peptide-1 production …
- Eriocalyxin B induces apoptosis and autophagy involving Akt/mammalian target of Rapamycin (mTOR) pathway in prostate cancer cells
- Rapamycin treatment ameliorates age-related accumulation of toxic metabolic intermediates in brains of the Ts65Dn mouse model of Down syndrome and …
- Interplay of autophagy inducer Rapamycin and proteasome inhibitor mg132 in reduction of foam cell formation and inflammatory cytokine expression
- Gymnemic acid I triggers mechanistic target of Rapamycin‐mediated β cells cytoprotection through the promotion of autophagy under high glucose stress
- Rapamycin ameliorates psoriasis by regulating the expression and methylation levels of tropomyosin via ERK 1/2 and mTOR pathways in vitro and in vivo
- l-Leucine influx through Slc7a5 regulates inflammatory responses of human B cells via mammalian target of Rapamycin complex 1 signaling
- Target of Rapamycin (TOR) determines appendage size during pupa formation of the red flour beetle Tribolium castaneum
- Rapamycin-induced autophagy decreases Myf5 and MyoD proteins in C2C12 myoblast cells
- Heterogeneity of phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of Rapamycin activation in cancer: Is PI3K isoform specificity important?
- Rapamycin enhances the sensitivity of ER‑positive breast cancer cells to tamoxifen by upregulating p73 expression
- inhibition of mammalian target of Rapamycin complex 1 signaling by n-3 polyunsaturated fatty acids promotes locomotor recovery after spinal cord injury
- … and new bone formation by cultured adipose tissue-derived stem cells through the IGF-1R/AKT/mammalian target of Rapamycin complex 1 (mTORC1) …
- Dysregulated expression of the key effectors of the mammalian target of Rapamycin signalling pathway in cutaneous papillomas of dogs
- Rapamycin-Loaded, CapryolTM 90 and Oleic Acid Mediated Nanoemulsions: Formulation Development, Characterization and Toxicity Assessment
- Compound C enhances tau phosphorylation at Serine396 via PI3K activation in an AMPK and Rapamycin independent way in differentiated SH-SY5Y cells
- The potential effects of hemp seed/evening primrose oils on the mammalian target of Rapamycin complex 1 and interferon-gamma genes expression in …
- Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells
- Identification of novel components of target-of-Rapamycin signaling pathway by network-based multi-omics integrative analysis
- Fructose and glucose can regulate mammalian target of Rapamycin complex 1 and lipogenic gene expression via distinct pathways
- Deficiency of apoptosis-stimulating protein two of p53 promotes liver regeneration in mice by activating mammalian target of Rapamycin
- … mesenchymal stem cells promote head and neck cancer progression through Periostin‐mediated phosphoinositide 3‐kinase/Akt/mammalian target of Rapamycin
- Long non‑coding RNA SENCR alleviates the inhibitory effects of Rapamycin on human umbilical vein endothelial cells
- Enhanced Rapamycin production through kinetic and purification studies by mutant strain of Streptomyces hygroscopicus NTG-30-27
- Prevention of post-ischemic seizure by Rapamycin is associated with deactivation of mTOR and ERK1/2 pathways in hyperglycemic rats
- Topical Rapamycin (sirolimus) for the treatment of uncomplicated tufted angiomas in two children and review of the literature
- Inhibitory effect of Rapamycin on proliferation of human umbilical arterial smooth muscle cells
- Clinically-Relevant Rapamycin Treatment Regimens Enhance CD8+ Effector Memory T Cell Function In The Skin and Allow their Infiltration into Cutaneous …
- Mechanistic target of Rapamycin pathway in epileptic disorders
- inhibition of the mammalian target of Rapamycin may augment the increase in soluble klotho levels in renal transplantation recipients
- … induces apoptosis of estrogen receptor-positive MG-63 osteosarcoma cells via the Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian target of Rapamycin …
- Circadian rhythms, metabolic oscillators, and the target of Rapamycin (TOR) pathway: the Neurospora connection
- Leucine regulates α-amylase and trypsin synthesis in dairy calf pancreatic tissue in vitro via the mammalian target of Rapamycin signalling pathway
- Adrenoceptor regulation of the mechanistic target of Rapamycin in muscle and adipose tissue
- Accelerated autophagy of cecal ligation and puncture-induced myocardial dysfunction and its correlation with mammalian target of Rapamycin pathway in rats
- A selective CD28 antagonist and Rapamycin synergise to protect against spontaneous autoimmune diabetes in NOD mice
- A component of the TOR (Target of Rapamycin) nutrient-sensing pathway plays a role in circadian rhythmicity in Neurospora crassa
- … reverses palbociclib resistance in ER+ human breast cancer cells by inhibiting phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of Rapamycin …
- … attenuates high glucose-mediated mesangial cell injury by inhibiting the phosphatidylinositol 3-kinase/Akt/mammalian target of Rapamycin (PI3K/Akt/mTOR) …
- Comparing the effects of the mTOR inhibitors azithromycin and Rapamycin on in vitro expanded regulatory T cells
- Development and characterisation of a panel of phosphatidylinositide 3-kinase–mammalian target of Rapamycin inhibitor resistant lung cancer cell lines
- Rapamycin rescues BMP mediated midline craniosynostosis phenotype through reduction of mTOR signaling in a mouse model
- … inhibitor, TUPS, attenuates isoproterenol/angiotensin II‐induced cardiac hypertrophy through mammalian target of Rapamycin‐mediated autophagy inhibition
- Pathology of calcineurin and mammalian target of Rapamycin inhibitors in kidney transplantation
- Calorie restriction and Rapamycin administration induce stem cell self-renewal and consequent development and production in the mammary gland
- Rapamycin exacerbates cardiovascular dysfunction after complete high-thoracic spinal cord injury
- Mechanistic target of Rapamycin (mTOR) in the cancer setting
- … multicentre randomised post-market trial to assess the safety and effectiveness of the Firehawk cobalt-chromium coronary stent (Rapamycin target-eluting) system for …
- Dynamic regulation of caveolin-1 phosphorylation and caveolae formation by mammalian target of Rapamycin complex 2 in bladder cancer cells
- Concentration‑dependent effects of Rapamycin on proliferation, migration and apoptosis of endothelial cells in human venous malformation
- Effects of long-term Rapamycin treatment on glial scar formation after cryogenic traumatic brain injury in mice
- Rapamycin liposome gutta inhibiting fungal keratitis of rats
- Successful reversal of ovarian hyperstimulation syndrome in a mouse model by Rapamycin, an mTOR pathway inhibitor
- Rapamycin alleviates hormone imbalance-induced chronic nonbacterial inflammation in rat prostate through activating autophagy via the mTOR/ULK1/ATG13 …
- The mTOR kinase inhibitor Rapamycin enhances the expression and release of pro-inflammatory cytokine interleukin 6 modulating the activation of human …
- … ‐1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure Through Sirtuin‐1/Mechanistic Target of Rapamycin Complex 2 and 5 …
- Ethanol-induced cognitive dysfunction is associated with alterations in the mammalian target of Rapamycin signalling pathway in the hippocampus of male mice
- Mammalian target of Rapamycin regulates a hyperresponsive state in pulmonary neutrophils late after burn injury
- Effect of silencing lncRNATUG1 on Rapamycin‑induced inhibition of endothelial cell proliferation and migration
- Mesenchymal stem cells in combination with low-dose Rapamycin significantly prolong islet allograft survival through induction of regulatory T cells
- MicroRNA-495 confers increased sensitivity to chemotherapeutic agents in gastric cancer via the mammalian target of Rapamycin (mTOR) signaling pathway …
- HPV-16 E7 expression up-regulates phospholipase D activity and promotes Rapamycin resistance in a pRB-dependent manner
- Integrin alpha V beta 3 targeted dendrimer‐Rapamycin conjugate reduces fibroblast‐mediated prostate tumor progression and metastasis
- Rapamycin provides anti‑epileptogenic effect in a rat model of post‑traumatic epilepsy via deactivation of mTOR signaling pathway
- Rapamycin− mTOR+ BRAF=? Using relational similarity to find therapeutically relevant drug-gene relationships in unstructured text
- Mammalian target of Rapamycin: A metabolic rheostat for regulating adipose tissue function and cardiovascular health
- Efficacy and Tolerance of Sirolimus (Rapamycin) for Extracranial Arteriovenous Malformations in Children and Adults
- In vitro evaluation of effects of metformin on morphine and methadone tolerance through mammalian target of Rapamycin signaling pathway
- High Glucose Affects the Cytotoxic Potential of Rapamycin, Metformin and Hydrogen Peroxide in Cultured Human Mesenchymal Stem Cells
- Amino acid starvation promotes podocyte autophagy through mammalian target of Rapamycin inhibition and transcription factor EB activation
- Rapamycin rescues endoplasmic reticulum stress–induced dry eye syndrome in mice
- Activation of the mammalian target of Rapamycin signaling pathway underlies a novel inhibitory role of ring finger protein 182 in ventricular remodeling after myocardial …
- Rapamycin–“One size does not fit all”
- Cross talk networks of mammalian target of Rapamycin signaling with the ubiquitin proteasome system and their clinical implications in multiple myeloma
- Rapamycin attenuates Th2-driven experimental allergic conjunctivitis
- A combined N-terminomics and shotgun proteomics approach to investigate the responses of human cells to Rapamycin and zinc at the mitochondrial level
- Lactobacillus casei protects dextran sodium sulfate-or Rapamycin-induced colonic inflammation in the mouse
- … synthetase-mediated essential amino acids regulate β-casein synthesis via cell proliferation and mammalian target of Rapamycin (mTOR) signaling pathway …
- MicroRNA-496 and mechanistic target of Rapamycin expression are associated with type 2 diabetes mellitus and obesity in elderly people
- … , leucine, methionine, threonine, and other amino acids on insulin and glucagon concentrations, mammalian target of Rapamycin (mTOR) signaling, and …
- Retraction: A005, a novel inhibitor of phosphatidylinositol 3-kinase/mammalian target of Rapamycin, prevents osteosarcoma-induced osteolysis.
- Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP/PS1 mouse
- Rapamycin attenuates a murine model of thoracic aortic aneurysm by downregulating the miR-126–3p mediated activation of MAPK/ERK signalling pathway
- Use of mammalian target of Rapamycin inhibitors for pancreas transplant immunosuppression is associated with improved allograft survival and improved early patient …
- Effect of topical Rapamycin 1% on multiple trichoepitheliomas
- Activation of mechanistic target of Rapamycin complex 1: the common link between rheumatoid arthritis and diabetes mellitus
- Dysplasia and overgrowth: magnetic resonance imaging of pediatric brain abnormalities secondary to alterations in the mechanistic target of Rapamycin pathway
- Rapamycin combi with TAE on the growth, metastasis, and prognosis of hepatocellular carcinoma in rat models
- Phase I Study of the BRAF Inhibitor Vemurafenib in Combination With the Mammalian Target of Rapamycin Inhibitor Everolimus in Patients With BRAF-Mutated …
- Favorable response to mammalian target of Rapamycin inhibition in a young patient with unresectable fibrolamellar carcinoma of the liver
- … inhibits colorectal cancer cell proliferation, migration and invasion via TYRO3 and phosphoinositide 3-kinase/protein B kinase/mammalian target of Rapamycin …
- … inhibits reactive oxygen species production and apoptosis in primary spinal cord neurons by activating autophagy via the mechanistic target of Rapamycin …
- Distinct patterns of gene expression in human cardiac fibroblasts exposed to Rapamycin treatment or methionine restriction
- … factor 1α (HIF-1α) promotes autophagy and inhibits Phosphatidylinositol 3-Kinase (PI3K)/AKT/Mammalian target of Rapamycin (mTOR) signaling pathway in …
- NR6A1 regulates lipid metabolism through mammalian target of Rapamycin complex 1 in HepG2 cells
- … relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of Rapamycin complex 1 (mTORC1)
- Effects of early exposure of isoflurane on chronic pain via the mammalian target of Rapamycin signal pathway
- Analyses of alveolar epithelial injury via lipid-related stress in mammalian target of Rapamycin inhibitor-induced lung disease
- The role of CIP2A as a therapeutic target of Rapamycin in radioresistant head and neck cancer with TP53 mutation
- Effects of NVP‑BEZ235, a dual phosphatidylinositol 3-kinase/mammalian target of Rapamycin inhibitor, on HTLV-1-infected T-cell lines
- … an antidiabetic drug, against ovarian cancer cells involves inhibition of cysteine-rich 61 (Cyr61)/Akt/Mammalian target of Rapamycin (mTOR) signaling pathway
- Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of Rapamycin complex 1 (mTORC1) inhibitors
- Mechanistic target of Rapamycin: integrating growth factor and nutrient signaling in the collecting duct
- … Restriction Was Attenuated by Oxidative-Stress-Induced inhibition of Vacuolar H+-Adenosine Triphosphatase/Mechanistic Target of Rapamycin Complex 1 Signaling
- Rapamycin and FK506 derivative TH2849 could ameliorate neurodegenerative diseases through autophagy with low immunosuppressive effect
- … Apoptosis in the NCI-H1650 Non-Small Cell Lung Cancer Cell Line via inhibition of AKT/Mammalian Target of Rapamycin (mTOR)/Ribosomal Protein S6 …
- Prevention of type 1 diabetes with acetalated dextran microparticles containing Rapamycin and pancreatic peptide P31
- Rapamycin attenuates pathological hypertrophy caused by an absence of trabecular formation
- Rapamycin prolongs graft survival and induces CD4+ IFN-γ+ IL-10+ regulatory type 1 cells in old recipient mice
- Hollow Fe3O4/graphene oxide nanocomposites as novel Rapamycin carrier: formulation optimization and in vitro characterization
- … GTPase-activating protein 1 regulates cytoskeletal reorganization and facilitates NKG2D-mediated mechanistic target of Rapamycin complex 1 activation and …
- Production, characterization, and cross-reactivity of a polyclonal antibody against Arabidopsis TARGET OF Rapamycin
- Differential effects of various genetic mouse models of the mechanistic target of Rapamycin complex I inhibition on heart failure
- Different roles of Akt and mechanistic target of Rapamycin in serum‑dependent chondroprotection of human osteoarthritic chondrocytes
- Glaucocalyxin A as a natural product increases amyloid β clearance and decreases tau phosphorylation involving the mammalian target of Rapamycin signaling …
- in vitro determination of Rapamycin-triggered FKBP–FRB interactions using a molecular tension probe
- … of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization, and function of Saccharomyces cerevisiae target of Rapamycin …
- Derivation of Rapamycin: adventures in natural product chemistry
- Performance, diameter of muscle fibers, and gene expression of mechanistic target of Rapamycin in pectoralis major muscle of broilers supplemented with leucine and …
- Biogenesis of Autophagosome in Trichomonas vaginalis during Macroautophagy Induced by Rapamycin‐treatment and Iron or Glucose Starvation Conditions
- Regulation of protein kinase cδ nuclear import and Apoptosis by Mechanistic target of Rapamycin Complex-1
- … and hydrodynamic injection and sequential stacking featuring sweeping for signal amplification following MEKC during the analysis of Rapamycin (sirolimus) in serum …
- Restoring T-helper 17 cell/regulatory T-cell balance and decreasing disease activity by Rapamycin and all-trans retinoic acid in patients with systemic lupus …
- Rapamycin and FTY720 alleviate atherosclerosis by cross talk of macrophage polarization and autophagy
- CLOVES syndrome: treatment with oral Rapamycin. Report of two cases
- Enhanced Rapamycin delivery to hemangiomas by lipid polymer nanoparticles coupled with anti-VEGFR antibody
- Insulin-mimetic effects of short-term Rapamycin in type 1 diabetic patients prior to islet transplantation
- Clinical monitoring challenges in the pharmacological treatment and management of lymphatic anomalies with mammalian target of Rapamycin inhibition
- Rapamycin inhibits the growth and collagen production of fibroblasts derived from human urethral scar tissue
- Osteopontin counters human immunodeficiency virus type 1–induced impairment of neurite growth through mammalian target of Rapamycin and beta-integrin …
- … effects of hemp seed/evening primrose oil supplement in comparison with Rapamycin on the expression of the mammalian target of Rapamycin-complex 2 and …
- Concomitant use of Rapamycin and rosiglitazone delays the progression of polycystic kidney disease in Han: SPRD rats: A study of the mechanism of action
- Poly (ADP‐ribose) polymerase 1 induces cardiac fibrosis by mediating mammalian target of Rapamycin activity
- Premature recruitment of oocyte pool and increased mTOR activity in Fmr1 knockout mice and reversal of phenotype with Rapamycin
- A unified mitochondria mechanistic target of Rapamycin acyl‐coenzyme A dehydrogenase 10 signal relay modulation for metformin growth inhibition in human …
- Epimagnolin targeting on an active pocket of mammalian target of Rapamycin suppressed cell transformation and colony growth of lung cancer cells
- Single injection of Rapamycin blocks post–food restriction hyperphagia and body-weight regain in rats.
- Hypertrophied myocardium is vulnerable to ischemia/reperfusion injury and refractory to Rapamycin-induced protection due to increased oxidative/nitrative stress
- Effects of minocycline and Rapamycin in gamma-irradiated human embryonic stem cells-derived cerebral organoids
- Hepatic phosphorylation status of serine/threonine kinase 1, mammalian target of Rapamycin signaling proteins, and growth rate in Holstein heifer calves in …
- Overexpression of Biglycan is Associated with Resistance to Rapamycin in Human WERI-Rb-1 Retinoblastoma Cells by Inducing the Activation of the …
- Effect of Rapamycin on the level of autophagy in rats with early heart failure
- Protein kinase C is a key target for attenuation of Leigh syndrome by Rapamycin
- Mammalian target of Rapamycin complex 1 activation disrupts the Low-Density lipoprotein receptor pathway: a novel mechanism for extracellular matrix accumulation …
- … by lowering drug resistance through inhibition of far-upstream element-binding protein 2-mediated phosphoinositide 3-Kinase/Akt/mammalian target of Rapamycin …
- Effects of inhibiting mTOR with Rapamycin on behavior, development, neuromuscular physiology and cardiac function in larval Drosophila
- … promotes the proliferation and migration of human glioma cancer cells through the protein kinase B/mechanistic target of Rapamycin pathway by phosphatase …
- Combining the mammalian target of Rapamycin inhibitor, Rapamycin, with resveratrol has a synergistic effect in multiple myeloma
- … protects the myocardium in sepsis by activating the phosphatidylinositol 3-kinases (PI3K)/AKT/mammalian target of Rapamycin (mTOR) pathway and inhibiting …
- Nanostructured lipid carriers containing Rapamycin for prevention of corneal fibroblasts proliferation and haze propagation after burn injuries: In vitro and in vivo
- … of cell migration and invasion, and suppression of phosphatidylinositol 3-kinases (PI3K)/AKT/mammalian target of Rapamycin (mTOR) signaling pathway
- … of economic evaluations of tyrosine kinase inhibitors of vascular endothelial growth factor receptors, mammalian target of Rapamycin inhibitors and programmed death …
- Insulin-like growth factor 1 inhibits autophagy of human colorectal carcinoma drug-resistant cells via the protein kinase B/mammalian target of Rapamycin …
- Simultaneous activation of impaired autophagy and the mammalian target of Rapamycin pathway in oral squamous cell carcinoma
- Correction: Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of akt/mammalian target of Rapamycin pathway
- Rapamycin enhances lytic replication of Epstein-Barr virus in gastric carcinoma cells by increasing the transcriptional activities of immediate-early lytic promoters
- Mammalian target of Rapamycin complex 2 signaling in obese women changes after bariatric surgery
- Activity dependent mammalian target of Rapamycin pathway and brain derived neurotrophic factor release is required for the rapid antidepressant effects of puerarin
- Rapamycin protects against early brain injury independent of cerebral blood flow changes in a mouse model of subarachnoid haemorrhage
- Expression of the miR-150 tumor suppressor is restored by and synergizes with Rapamycin in a human leukemia T-cell line
- Locomotor treadmill training promotes soleus trophism by mammalian target of Rapamycin pathway in paraplegic rats
- A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction
- Discovery of the actinoplanic acid pathway in Streptomyces Rapamycinicus reveals a genetically conserved synergism with Rapamycin
- Molecular interplay between hyperactive mammalian target of Rapamycin signaling and Alzheimer’s disease neuropathology in the NS-Pten knockout mouse model
- … against advanced renal cell carcinoma by dual targeting of Akt/pyruvate kinase muscle isozyme M2 and mechanistic target of Rapamycin complex 1 pathways
- The putative transcription factor CaMaf1 controls the sensitivity to lithium and Rapamycin and represses RNA polymerase III transcription in Candida albicans
- Myeloid-derived suppressor cells (MDSCs) and mechanistic target of Rapamycin (mTOR) signaling pathway interact through inducible nitric oxide synthase …
- Rapamycin exposure to host and to adult worms affects life history traits of Heligmosomoides bakeri
- Rapamycin‑induced autophagy attenuates hormone‑imbalance‑induced chronic non‑bacterial prostatitis in rats via the inhibition of NLRP3 inflammasome …
- Genetic defects in SAPK signalling, chromatin regulation, vesicle transport and CoA-related lipid metabolism are rescued by Rapamycin in fission yeast
- Effects and Mechanisms of Rapamycin Action on Experimental Neurodegeneration
- Mechanistic target of Rapamycin (mTOR) implicated in plasticity of the reproductive axis during social status transitions
- … attenuates airway inflammation by suppressing autophagy via phosphatidylinositol 3‐kinase/protein kinase B/mammalian target of Rapamycin signaling pathway in rat …
- CLAPO syndrome: Effective response to treatment with oral Rapamycin
- Ketamine effects on mammalian target of Rapamycin signaling in the mouse limbic system depend on functional dopamine D3 receptors
- Novel function of cyclooxygenase-2: suppressing mycobacteria by promoting autophagy via the protein kinase B/mammalian target of Rapamycin pathway
- … Epithelial-to-Mesenchymal Transition (EMT) progression and Adenosine Monophosphate Activated Protein Kinase (AMPK)/Mammalian Target of Rapamycin …
- … proliferation of human ovarian cancer cells in vitro via the phosphatidylinositol-3-kinase (PI3K)/akt and the mammalian target of Rapamycin (mTOR) and Wnt/β …
- Role of mammalian target of Rapamycin signaling pathway in regulation of fatty acid oxidation in a preeclampsia-like mouse model treated with pravastatin
- Long-Term Exposure and Safety of a Novel Topical Rapamycin Cream for the Treatment of Facial Angiofibromas in Tuberous Sclerosis Complex: Results From a …
- PPP2R2D, a regulatory subunit of protein phosphatase 2A, promotes gastric cancer growth and metastasis via mechanistic target of Rapamycin activation
- Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of Rapamycin signaling
- Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish
- Cloning and characterization of the target protein subunit lst8 of Rapamycin in Apostichopus japonicus
- Target of Rapamycin FATC domain as a general membrane anchor: The FKBP‐12 like domain of FKBP38 as a case study
- Stable isotope labeling reveals novel insights into ubiquitin-mediated protein aggregation with age, calorie restriction, and Rapamycin treatment
- The correlation between mammalian target of Rapamycin (mTOR) gene expression and sperm DNA damage among infertile patients with and without varicocele
- CC-115, a Dual mammalian target of Rapamycin/DNA-dependent protein kinase inhibitor in clinical trial, is a substrate of ATP-binding cassette G2, a risk factOR for …
- Facial angiofibromas treated by Rapamycin 0.05% ointment and a combined laser therapy
- … are mediated via mitochondrial-mediated apoptosis, inhibition of cell migration, invasion suppression, and mammalian target of Rapamycin (mTOR)-TOR/PI3K …
- The Continuous Story of the Miraculous Drug, Rapamycin
- … lysine/methionine ratios and glucose levels and their effects on casein synthesis via activation of the mechanistic target of Rapamycin signaling pathway in …
- The combination of NVP‑BEZ235 and Rapamycin regulates nasopharyngeal carcinoma cell viability and apoptosis via the PI3K/AKT/mTOR pathway
- CD8+ T cells: mechanistic target of Rapamycin and eukaryotic initiation factor 2 in elite HIV-1 control
- Rapamycin blocks the neuroprotective effects of sex steroids in the adult birdsong system
- Orexin-A Stimulates Insulin Secretion Through the Activation of the OX1 Receptor and Mammalian Target of Rapamycin in Rat Insulinoma Cells
- Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea
- Sepsis-induced myocardial dysfunction and mammalian target of Rapamycin signalling pathways
- Rapamycin induces an eNOS dependent increase in brain collateral perfusion after acute experimental stroke in rats
- Polycystin-2 is required for starvation-and Rapamycin-induced atrophy in myotubes
- Current Update on Rapamycin Production and its Potential Clinical Implications
- The effects of AICAR and Rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts
- Tivantinib hampers the proliferation of glioblastoma cells via PI3K/Akt/Mammalian Target of Rapamycin (mTOR) signaling
- … lignocaine exhibits potent antilung cancer cell activity by inhibiting the phosphoinositide 3-kinases/mammalian target of Rapamycin/mammalian target of Rapamycin …
- Systemic Rapamycin Attenuates Morphine-Induced Analgesic Tolerance and Hyperalgesia in Mice
- Integrating microRNA and mRNA expression in Rapamycin-treated T-cell acute lymphoblastic leukemia
- Gastric Mammalian Target of Rapamycin Signaling Contributes to inhibition of Ghrelin Expression Induced by Roux-En-Y Gastric Bypass
- Neuroprotective effect of Rapamycin against Parkinson’s disease in mice
- Second-line treatment after sunitinib therapy in patients with renal cell carcinoma: a comparison of axitinib and mammalian target of Rapamycin inhibitors
- Effects of Rapamycin in combination with fludarabine on primary chronic lymphocytic leukemia cells
- Rapamycin affect the apoptosis of splenic CD4+ CD25+ regulatory T cells of mouse severe aplastic anemia model
- Role of mammalian target of Rapamycin activation in menthol-induced expressions of airway inflammation-related factors in human bronchial epithelial cells in vitro
- Local intra-articular injection of Rapamycin inhibits NLRP3 activity and prevents osteoarthritis in mouse DMM models
- Rapamycin increases breast tumor burden in young wheel-running mice
- Decreased Expression of Urinary Mammalian Target of Rapamycin mRNA Is Related to Chronic Renal Fibrosis in IgAN
- Rapamycin induces the expression of heme oxygenase-1 and peroxyredoxin-1 in normal hepatocytes but not in tumorigenic liver cells
- Activation of mammalian terget of Rapamycin kinase and glycogen synthase kinase‐3β accompanies abnormal accumulation of cholesterol in fibroblasts from …
- … expression of muscle RING‐finger protein‐1 and muscle atrophy F‐box proteins and proteins involved in the mechanistic target of Rapamycin pathway and autophagy …
- Rapamycin protects against paraquat‑induced pulmonary epithelial‑mesenchymal transition via the Wnt/β‑catenin signaling pathway
- … (mRCC) treated with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) and mammalian target of Rapamycin inhibitors (mTORI) after …
- Rapamycin administration during normal and diabetic pregnancy effects the mTOR and angiogenesis signaling in the rat placenta
- … neointima hyperplasia after vascular injury via p-adenosine 5′-monophosphate-activated protein kinase/mammalian target of Rapamycin complex 1 pathway
- inhibition of mammalian target of Rapamycin decreases intrarenal oxygen availability and alters glomerular permeability
- Chromosomal Instability and Evolution of Transformed Phenotype in Cell Lines Selected from Senescent Rat Embryonic Fibroblasts with Rapamycin
- Renal Cell Carcinoma Associated With Xp11. 2 Translocation/TFE3 Gene-fusion: A Long Response to mammalian target of Rapamycin (mTOR) Inhibitors
- A combination regimen of low-dose bortezomib and Rapamycin prolonged the graft survival in a murine allogeneic islet transplantation model
- Synthesis and anticancer activity of novel Rapamycin C‐28 containing triazole moiety compounds
- Correction to: The mTOR inhibitor Rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells
- Co-localization of insulin-like growth factor binding protein-1, casein kinase-2β, and mechanistic target of Rapamycin in human hepatocellular carcinoma cells …
- Oral Preconditioning of Donors After Brain Death With Calcineurin Inhibitors vs. Inhibitors of Mammalian Target for Rapamycin in Pig Kidney Transplantation.
- Efficacy and Safety of Mammalian Target of Rapamycin Inhibitor Use—Long-term Follow-up of First Tuberous Sclerosis Complex Patient Treated De Novo With …
- Cysteine‐rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of Rapamycin complex 1 and canonical Wnt …
- Retrospective study of Rapamycin or rapalog 0· 1% cream for facial angiofibromas in tuberous sclerosis complex: evaluation of treatment effectiveness and cost
- … Flux in Human Bone Mesenchymal Stromal Cells via NMDA Receptor–Ca2+–Extracellular Signal-Regulated Kinase–Mammalian Target of Rapamycin …
- Variability of the mammalian target of Rapamycin inhibitors is correlated with long-term renal graft survival
- inhibition of 5‐Hydroxytryptamine Receptor 2B Reduced Vascular Restenosis and Mitigated the β‐Arrestin2–Mammalian Target of Rapamycin/p70S6K Pathway
- Assessing the mechanistic target of Rapamycin complex-1 pathway in response to resistance exercise and feeding in human skeletal muscle by multiplex assay
- Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice
- A Photo‐Stable Indocyanine Green and Rapamycin Co‐Delivery System Based on Poly (Glutamic Acid)‐Modified Manganese Phosphate for Synergetic Tumor …
- Early Switch to Mammalian Target of Rapamycin Inhibitors Is a Sustainable Treatment Approach in Renal Transplant Recipients: 7-Year Results
- Captopril suppresses hepatic mammalian target of Rapamycin cell signaling and biomarkers of inflammation and oxidative stress in thioacetamide-induced …
- Rapamycin-induced Protein Dimerization as a Tool for C. elegans research
- … and inflammatory response by Rapamycin in target and distant organs in rats exposed to hindlimb ischemia–reperfusion: the role of mammalian target of Rapamycin
- FRI0063 Rapamycin induces remission in patients with refractory rheumatoid arthritis
- Laser-Assisted Delivery of Topical Rapamycin: mTOR inhibition for Birt–Hogg–Dube Syndrome
- Influence of phosphatidylinositol-3-kinase/protein kinase b-mammalian target of Rapamycin signaling pathway on the neuropathic pain complicated by …
- Rapamycin and ZSTK474 can have differential effects at different post‑infection time‑points regarding CVB3 replication and CVB3‑induced autophagy
- … in vitro and in mouse tumor xenografts and activates autophagy and apoptosis by downregulation of the mammalian target of Rapamycin (mTOR)/PI3K/AKT …
- AB0536 Rapamycin attenuates symptom and restores the balance of th17/treg in refractory primary sjogren’s syndrome
- Suren Sehgal & The Story of Rapamycin
- Molecular Mechanisms in Signaling by Target of Rapamycin Complex 2 in Saccharomyces cerevisiae
- Analysis of the inhibitory effect of Rapamycin on Fusarium asiaticum by next generation RNA sequencing
- Bioinformatics analysis of gefitinib or Rapamycin on inhibiting the survival of hela in the low glucose and high lactic acid environment
- Semisynthesis of 3‐Hydroxyoxindole Rapamycin Analogues Through Site‐ and Stereoselective Trapping of Oxonium Ylides in RhII‐Catalyzed Three‐Component …
- Rapamycin alleviated pulmonary injury induced by fat embolism syndrome in rats
- AB0376 Rapamycin induces remission in patients with newly diagnosed rheumatoid arthritis
- Effect of mechanistic target of Rapamycin inhibitors on postrenal transplantation malignancy: A nationwide cohort study
- Central action of Rapamycin on early ischemic injury and related cardiac depression following experimental subarachnoid hemorrhage
- … electromagnetic fields inhibit osteoclast differentiation in RAW264. 7 macrophages via suppression of the protein kinase B/mammalian target of Rapamycin …
- Assessing the efficacy of mammalian target of Rapamycin inhibitors by phosphorylation of p70S6K in CD4-positive cells of liver transplant patients
- CK2 Inhibitor CX4945 Shows Strong In Vivo Synergistic Anti-Leukemia Activity with Rapamycin in B-ALL Due to Enhanced Ikaros Mediated Repression of mTOR …
- The role of mammalian target of Rapamycin pathway in the pathogenesis of pauci-immune glomerulonephritis
- Response to Mammalian Target of Rapamycin–Based Therapy and Incidental Finding of Lynch Syndrome in a Patient With Solid Pseudopapillary Neoplasm …
- Redox-proteomes of human NOS1-transduced versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum-free starvation, and Rapamycin …
- Activation of mammalian target of Rapamycin induces lipid accumulation in the diaphragm of ventilated rats and hypoxia-treated C2C12 cells
- Reversible Suppression of Lymphoproliferation and Thrombocytopenia with Rapamycin in a Patient with Common Variable Immunodeficiency
- Construction of a mutant of Actinoplanes sp. N902-109 that produces a new Rapamycin analog
- The protective effect and mechanism of Rapamycin in the rat model of IgA nephropathy
- Silent information regulator 1 negatively regulates atherosclerotic angiogenesis via mammalian target of Rapamycin complex 1 signaling pathway
- Rapamycin in the treatment of renal diseases associated with tuberous sclerosis complex
- P. 255Possible efficacy of Rapamycin on myodegeneration in VCPDM mouse model
- A NOVEL APPROACH IN COLORECTAL CANCER AND DIABETES MANAGEMENT: ROLE OF METFORMIN AND Rapamycin
- B-cell-specific mammalian target of Rapamycin complex 1 activation results in severe osteoarthritis in mice
- A novel diazoresin/Rapamycin covalent capillary coating for the separation of biomacromolecules by capillary electrophoresis
- Role of LncRNA MALAT-1 and MicroRNA-199 in Rapamycin induced cardioprotection against reperfusion injury in diabetic rabbits
- Treatment of benign cephalic histiocytosis with topical 1% Rapamycin ointment
- inhibition of Nasopharyngeal Carcinoma by Beta-Lapachone Occurs by Targeting the Mammalian Target of Rapamycin (mTOR)/PI3K/AKT Pathway, Reactive …
- Does mammalian target of Rapamycin or sestrin 1 protein signaling have a role in bone fracture healing?
- Deregulated phospholipase D2/mammalian target of Rapamycin/hypoxia-inducible factor 1 alpha in peripheral T lymphocytes of oral lichen planus correlated with …
- Synergistic cytoprotection by co-treatment with dexamethasone and Rapamycin against proinflammatory cytokine-induced alveolar epithelial cell injury
- Evidence that decreased expression of sinusoidal bile acid transporters accounts for the inhibition by Rapamycin of bile flow recovery following liver ischemia
- SP772 Rapamycin PROMOTES CELLULAR DEATH THROUGH THE ACTIVATION OF AUTOPHAGY VIA P75NTR IN KAPOSI SARCOMA CELLS
- Rapamycin Suppresses TGF-β1-Induced Nasopharyngeal Cancer Stem Cell Metastasis by Inhibiting Mitochondrial Metabolism
- Research advances in the mammalian target of Rapamycin signaling pathway and its inhibitors in treatment of hepatocellular carcinoma
- The impact of mammalian target of Rapamycin inhibition on bone health in postmenopausal women with hormone receptor-positive advanced breast cancer …
- Mammalian target of Rapamycin inhibitors in a patient with polycystic kidney disease-1-tuberous sclerosis-2 contiguous gene syndrome
- siRNA blocking of mammalian target of Rapamycin (mTOR) attenuates pathology in annonacin-induced tauopathy in mice
- Effect of Rapamycin on mesenchymal stem cells treatment for swine myocardial infarction
- Amino Acid-and Insulin-Induced Activation of Mechanistic Target of Rapamycin Complex 1 in Neonatal Piglet Skeletal Muscle Involves Sestin2-GATOR2, Rag A/C …
- Enhanced Production of Anti-PD1 Antibody in CHO Cells through Transient Co-Transfection with Anti-Apoptotic Gene Bcl-xL Combined with Rapamycin
- Metformin: Antineoplastic Activity through the Mammalian Target of Rapamycin Pathway
- 4-Phenylbutyric acid and Rapamycin improved diabetic status in high fat diet/streptozotocin-induced type 2 diabetes through activation of autophagy
- … Papillomavirus of High Oncogenic Potential in Immunosuppressed Women on Renal Replacement Therapy With and Without Mammalian Target of Rapamycin …
- The Mammalian Target of Rapamycin–70-kDa Ribosomal Protein S6 Kinase Axis Inhibits the Biological Function of Tongue Squamous Cell Carcinoma
- Assessment of drug–drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of Rapamycin kinase
- Regression of renal angiomyolipomas with oral Rapamycin therapy in a patient with tuberous sclerosis complex disease
- Combined treatment with simvastatin and Rapamycin attenuates cardiac allograft rejection through the regulation of T helper 17 and regulatory T cells
- Differential expression of phospho‐S6 in hair follicle tumors: Evidence of mammalian target of Rapamycin pathway activation
- Impact of Rapamycin on Genome Organization
- Srategies for enhanced production of Rapamycin
- Targeting Cancer cell metabolism via Target of Rapamycin
- INTERVENTION WITH Rapamycin TO IMPROVE HEALTHY AGING AND LONGEVITY IN A NON-HUMAN PRIMATE
- Kaposi Sarcoma in the Era of Rapamycin Remains a Therapeutic Challenge in Organ Transplant Recipients.
- Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
- The mammalian target of Rapamycin protein expression in human granulosa cell tumors
- Effects of Rapamycin on chromatin–implications for ageing and tumour suppression
- Mammalian Target of Rapamycin Inhibitors and Survival in Heart Transplant Recipients: Miracle or Mirage?
- Reply: Mammalian Target of Rapamycin Inhibitors and Survival in Heart Transplant Recipients: Miracle or Mirage?
- Differential Roles of Mammalian Target of Rapamycin Complexes 1 and 2 in Migration of Prostate Cancer Cells
- Mitigation of Inflammation Induced By Monosodium Urate Crystals in Mice By Treatment with SVP-Rapamycin
- Arterial infusion of Rapamycin in the treatment of rabbit hepatocellular carcinoma to improve the effect of TACE
- … 2 Clinical Data of SEL-212 in Symptomatic Gout Patients: Monthly Dosing of a Pegylated Uricase (Pegadricase) with Svp-Rapamycin Enables Sustained Reduction of …
- Treatment with Rapamycin or Rapamycin in combination with metformin contributes to mechanisms of mitochondrial proteostasis in vivo and in vitro
- GW29-e1749 Delayed reendothelialization with Rapamycin is rescued by the addition of nicorandil in balloon-injured rat carotid arteries
- The effects of Rapamycin on the symptoms of cerebral ischemia due to changing the expression of miR-1 and its target genes, Bad and Bcl-w
- Correction: Rapamycin Is Neuroprotective in a Rat Chronic Hypertensive Glaucoma Model
- Successful transcatheter aortic valve replacement in a kidney allograft patient on Rapamycin
- Pre-treatment with Rapamycin protects hematopoiesis against radiation injury
- Role of Mammalian Target of Rapamycin in Muscle Growth
- Anti-scarring effect of Rapamycin in rabbits following glaucoma filtering surgery
- Target Of Rapamycin pathway in the white-rot fungus Phanerochaete chrysosporium
- Synergy of Rapamycin and Cyanoacrylate in Reducing Intimal Hyperplasia
- 067 Rapamycin Suppresses NADPH Oxidase-mediated Reactive Oxygen Species Production and Reverses Erectile Dysfunction in Western Diet-fed Mice
- Viability, Growth and Reproduction of Heligmosomoides bakeri During a Secondary Infection of a Host Treated with Rapamycin
- Use of Topical Rapamycin as Maintenance Treatment after a Single Session of Fractionated CO 2 Laser Ablation: A Method to Enhance Percutaneous Drug …
- Discovery of potential mammalian target of Rapamycin inhibitors: A combination of virtual screening and molecular docking studies.
- Mathematical modelling of mammalian target of Rapamycin following leucine ingestion
- Wound Repair and the Immune System in the Presence of Rapamycin
- SAT0280 Rapamycin restores the balance between th17 and regulatory t cells in uspa patients
- Synergistic antifibrotic effect of Rapamycin and Zoledronic acid in advanced murine biliary fibrosis
- Production of interleukin-1β related to mammalian target of Rapamycin/Toll-like receptor 4 signaling pathway during Aspergillus fumigatus infection of the …
- AB0382 Rapamycin selectively increases circulating tregcellsand maintain remission of patients with rheumatoid arthritis
- Local release of Rapamycin by microparticles delays islet rejection within the anterior chamber of the eye
- Regarding “Rapamycin prevents thoracic aortic aneurysm and dissection in mice”
- Rapamycin Promote the inhibition Rate of Proliferation on SHI-1 Cells and Enhance the Efficacy of Chemotherapy in Npg Leukemia Mice
- ANTI-CELL SENESCENT EFFECTS OF Rapamycin AND THEIR ROLE IN DISEASES, INCLUDING ALZHEIMER’S
- Different expression patterns of exosomal miRNAs under Cyclosporin A and Rapamycin treatment in distinct aggressiveness colorectal carcinomas
- Targeting Delivery of Rapamycin With Anti-Collagen IV Peptide Conjugated Fe₃O₄@ Nanogels System for Vascular Restenosis Therapy
- Rapamycin alleviates inflammation by up-regulating TGF-β/Smad signaling in a mouse model of autoimmune encephalomyelitis
- Intranasal Rapamycin protects against cognitive decline in a mouse model of Down syndrome
- Farnesyltransferase inhibitor and Rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson–Gilford progeria syndrome …
- Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression in a …
- Efficacy of brain-targeted Rapamycin for treatment of epilepsy in rats
- AN EXPERIMENTAL RESEARCH OF THE EFFECTS OF Rapamycin ON THE IN VITRO PROLIFERATION AND GROWTH OF TREGS IN MICE BY …
- Rapamycin-Based Expansion of Natural CD8+ Tregs for Cell Therapy
- Metabolic regulation of insulin secretion: the link between excess glucose, mechanistic target of Rapamycin complex 1 & hyperinsulinemia
- Autophagy in Hepatocellular Carcinoma-29 after Single or Combined Administration of Lithium Carbonate and Rapamycin
- Belatacept and Rapamycin with Short-Term Use of Tacrolimus Delay Allograft Rejection in a Novel, Large Animal Vascularized Composite Allotransplantation Model
- The Effect of Acute Aerobic Exercise and Rapamycin Treatment on Autophagy and the Heat Shock Response in Peripheral Blood Mononuclear Cells of Prediabetics
- A Randomized Trial of Rapamycin to Increase Longevity and Healthspan in Companion Animals: Navigating the Boundary Between Protections for Animal Research …
- Use of TGF-beta plus Rapamycin to Induce Foxp3, promote iTreg Development and Suppressive Function, and Induce Long-Term Allograft Survival
- Rapamycin decreases presenilin-1 in SK-N-SH cells
- Deep proteome of human nNOS/NOS1-positive versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum free starvation and Rapamycin …
- Immunohistochemical study of folate receptor-α and mammalian target of Rapamycin in endometrial hyperplasia and endometrioid endometrial carcinoma
- Advance of Mechanisms and Clinical Applications about Rapamycin for Treating Immune Mediated Hemocytopenia–Review
- Mammalian target of Rapamycin inhibitor and transarterial embolization for treatment of tuberous sclerosis complex patients with renal angiomyolipoma
- P126/O29 mTOR blockade by Rapamycin decreases arthritis and spondylitis development and severity in HLA-B27 transgenic rats
- Efficacy and Safety of Early Mammalian Target of Rapamycin Inhibitors with Minimization of Calcineurin Inhibitors in Kidney Transplant Recipients
- … kinase (CHK1) inhibitor, and LY3023414, a dual inhibitor of class I phosphatidylinositol 3-kinase (PI3K) and the mammalian target of Rapamycin (mTOR) in patients …
- New Use of Rapamycin Stent in Non-Responding Facial Lymphatic Malformation
- Roles of Mammalian Target of Rapamycin Signaling and Autophagy Pathway in Alzheimer’s Disease
- Erratum: Rapamycin-induced protein dimerization as a tool for C. elegans research. microPublication Biology
- FRI0150 mTOR blockade by Rapamycin decreases arthritis and spondylitis development and severity in hla-b27 transgenic rats
- Lung Function Response and Changes of Lung Cysts to Rapamycin for Lymphangioleiomyomatosis: Long-Term Follow-Up Observational Study
- Rapamycin Induces Apoptosis of K562 Cells through EZH2/Hedgehog Signaling Pathway
- Rapamycin prevents surgery-induced T cell exhaustion in patients with bladder cancer
- Safety and Effectiveness of FlexyRap® Cobalt-Chromium Rapamycin-Eluting Stents with Biodegradable Polymer in Coronary Artery Disease: Results from a 2 …
- Clinical importance of microtubule-associated protein 1 light chain 3 and mammalian target of Rapamycin expression in oral leukoplakia and oral squamous cell …
- Evaluation of the interaction between melatonin and Rapamycin for head and neck cancer therapy
- A new mTOR-independent effect of Rapamycin: Transcriptional regulation of TRIB3
- INTERACTION OF ALPHA SYNUCLEIN WITH TARGET OF Rapamycin (TOR): A REVIEW
- Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression in a …
- Mammalian target of Rapamycin: biological functions and mechanisms.
- Rapamycin attenuates Th2-driven experimental allergic conjunctivitis
- Rapamycin partially rescues oocyte dysfunction in mice deficient for mitochondrial stress response protein CLPP
- Impaired follicular development and ovulation in PCOS mouse model can rescued by Rapamycin treatment
- The activity of S. pombe LTR retrotransposons is activated in response to Rapamycin
- Combination of Rapamycin with immune checkpoint blockade in a syngeneic breast carcinoma model
- Combination of Rapamycin and Resveratrol for Treatment of Bladder Cancer.
- Overexpression of regulatory gene rapG enhances the yield of Rapamycin.
- THU0098 Combination therapy of Rapamycin and a glutamine antagonist facilitates the expansion of myeloid-derived suppressor cells and ameliorates arthritis in skg …
- Toward Novel Therapeutics for TSC and LAM: Using Mechanisms of a Bacterial Protein to Sensitize Cells to Rapamycin
- Neuroprotective Effects of the Small-Molecule Enhancer of Rapamycin in the Cellular Model of Parkinson’s Disease
- Rapamycin treatment starting at 24 h after cerebral ischemia/reperfusion exhibits protective effect on brain injury in rats
- Resistance Reversion of Rapamycin on Ovarian Cancer Cell Line SKOV3/DDP and Its Molecular Mechanisms
- Discovery of Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors
- The mammalian target of Rapamycin complex 1 (mTORC1) and the regulation of opioid efficacy
- Consensus Statement: sirolimus (Rapamycin) as therapy for lymphangioleiomyomatosis (2018)
- Evaluation of the Effects of Nicotine on Mammalian Target of Rapamycin Complex 2 and Signal Transducer and Activator of Transcription 3 Genes Expression …
- Expression of autophagy level in the aorta of diabetic rats and the intervention effect of Rapamycin
- Sugar and spice in epilepsy: Modulation of epilepsy and epileptogenesis by Rapamycin and curcumin in experimental models of temporal lobe epilepsy
- Retracted: Rapamycin prevents apoptosis of myocardial cells in heart failure rats through up-regulating Akt
- Effect of Rapamycin on gene expression of nuclear factor-? B p65 and STAT-1 in sprague-dawley rats with acute lung injury
- Expression and Clinical Significance of Late Endosomal/Lysosomal Adaptor, Mitogen-activated Protein Kinase and Mammalian Target of Rapamycin Activator 3 in …
- Autophagy and Expression of UCH-L3 Induced by Rapamycin in HL-60 Cells
- MON-LB054 Activity of Prolactin Receptor Antagonist-Rapamycin Conjugate in Glioblastoma Multiform
- siRNA Blocking of Mammalian Target of Rapamycin (mTOR) Attenuates Toxicity in Annonacin Induced Tauopathy in Mice
- Effect of Rapamycin on expression of Caspase-9 and Ki-67 in neuroendocrine tumor tissues
- IGF2 as a Potential Novel Therapeutic Target for Rapamycin-Insensitive LAM Patients
- TCT-624 A prospective multicenter randomized post-market trial evaluating a novel Cobalt Chrome Rapamycin Drug Eluting Stent: Subgroup Analysis of the TARGET …
- Rapamycin suppresses T cell responses in recoverin-induced autoimmune retinopathy and prevents disease progression in the eyes
- Rapamycin-eluting stents for unprotected left main coronary artery stenosis in older adult patients with coronary atherosclerosis: study protocol for a …
- Rapamycin Treatment Promotes Myofibril Relaxation Kinetics and Reduces Myocardial Stiffness to Improve Diastolic Function in Old Murine Hearts
- Disruption of Mammalian Target of Rapamycin Complex 1 in Myeloid cells Promotes Lung Cancer Metastasis
- Abstract# 3183 Treatment with Rapamycin affects behavioral and brain protein expression in rats with experimentally induced glioblastoma
- Effect of Rapamycin on the biological behaviors of human non-Hodgkin lymphoma Raji cells and its mechanism
- Immunohistochemical evaluation of p-mTOR (Phosphorylated Mammalian Target of Rapamycin) in oral squamous cell carcinoma
- Rapamycin-induced autophagy of Ana-1 cells play the lethality to melanized Penicillium marneffei
- THE EFFECTS OF 4 WEEKS HIGH INTENSITY INTERVAL TRAINING ON MAMMALIAN Rapamycin TARGET PROTEIN (mTOR) AND STEROL TRANSCRIPTION …
- Rapamycin Protects Against Paraquat-induced Pulmonary Epithelial Mesenchymal Transition through Wnt/β-catenin Pathway
- Rapamycin promotes trans-differentiation while inhibiting mTOR activity in glioblastoma cells
- Efficacy of self-made Gengnian decoction on phosphatidylinositol 3-kinases/protein kinase B/mammalian target of Rapamycin signaling pathway in perimenopausal …
- TREATMENT OF BETA-THALASSEMIA PATIENTS WITH Rapamycin (SIROLIMUS): FROM PRE-CLINICAL RESERCH TO A CLINICAL TRIAL
- Cuprizone model of demyelination in the presence of mTOR inhibitor Rapamycin
- BD-02 Blockade of the mechanistic target of Rapamycin elicits rapid and lasting improvement of disease activity through restraining pro-inflammatory T cell …
- Rapamycin protects human lens epithelial cells against oxidative stress induced by high glucose
- IGF-Ⅱrestores Rapamycin-induced suppression of β-cell differentiation and expansion of adult pancreas stem cells
- Roles of Mechanistic Target of Rapamycin Complexes in Retinal Development and Visual Function
- Investigation of Functionally Important Residues in Histone Variant H2A. Z and the Effect of Rapamycin on Saccharomyces Cerevisiae
- Mechanistic target of Rapamycin enhances fibrosis in lung by promoting epithelial mesenchymal transition
- MP38-06 Rapamycin REGULATION OF CORE CLOCK GENES IS ASSOCIATED WITH ALTERED DE-OBSTRUCTION SIGNATURES COORDINATE WITH …
- Case Report: Surgical trauma induces overgrowth in lower limb gigantism: regulation with use of Rapamycin is promising
- Delivery of Rapamycin-enriched Nanoparticles to Atherosclerotic Plaques Provides Targeted Regulation of the Macrophage mTORc1-autophagy Signaling Axis
- PD-L1 as a Notential Therapeutic Target for Patients with Advanced or Refractory-to-Rapamycin Pulmonary Lymphangioleiomyomatosis (LAM)
- The Mammalian Target of Rapamycin (mTOR)/Peroxisome Proliferator-Activated Receptor γ (PPARγ) axis drives immune dysfunction and outcome after burn injury.
- Regulation of central carbon and nitrogen metabolism by Target of Rapamycin (TOR) kinase in Chlamydomonas reinhardtii
- Effects of Rapamycin and mammalian target of Rapamycin-small interfering RNA (mTOR siRNA) on proli-feration, apoptosis and extracellular matrix in premature rats …
- Original Investigation The mammalian target of Rapamycin protein expression in human granulosa cell tumors Güralp et al. mTOR protein expression in …
- Effect of Rapamycin on the expression of autophagy-related proteins Unc-51 like autophagy activating kinase 1 and microtubule-associated protein 1 light chain 3 in …
- Rapamycin protect puromycin amino nucleoside induced podocyte injury by up-regulating autophagy
- Rapamycin Alters MicroRNA Signature Profile in Diabetic Rabbit following Myocardial Ischemia Reperfusion Injury: A Preclinical Approach for Cardioprotection.
- Effects of postruminal amino acid supplementation on protein deposition and the mammalian target of Rapamycin signaling pathway in growing steers
- Elastin-like polypeptide mediate subcutaneous delivery of Rapamycin in a murine model of Sjögren’s Syndrome
- Rapamycin and Zoledronic Acid strongly retard growth of advanced murine hepatocellular carcinoma via skewing and activation of innate and adaptive immunity
- Rapamycin-eluting stents for unprotected left main coronary artery stenosis in coronary atherosclerosis in the older adults: study protocol for a prospective, non …
- Rapamycin and Zoledronic acid exert a potent antifibrotic effect in murine biliary fibrosis
- Proteomics study of Rapamycin-injured human coronary artery endothelial cells based on two dimension fluorescence differential gel electrophoresis
- Rapamycin promotes the survival and angiogenesis of high glucose-exposed human umbilical vein endothelial cells by improving autophagy
- Rapamycin Can Ameliorate Antiretroviral Drug Mediated Cardiotoxicity
- Correction to: Mammalian Target of Rapamycin 2 (mTOR2) and C-MYC Modulate Glucosamine-6-Phosphate Synthesis in Glioblastoma (GBM) Cells Through …
- Rapamycin Treatment Reduces Myocardial Stiffness and Promotes Cardiomyocyte Relaxation to Restore Diastolic Function in Old Murine Hearts
- Dissecting Rapamycin resistance in a Tsc2-null rat leiomyoma cell line developed in a murine xenograft
- The role of mechanistic target of Rapamycin complex 2-component RICTOR in hepatocellular carcinoma progression and sorafenib-resistance
- Tuberin S1365 Phosphorylation Regulates Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathological Signaling While Sustaining Metabolic Sensor …
- Discovery and evaluation of WX047, a potent and oral active phosphoinositide 3-kinase (PI3K)/mammalian target of Rapamycin (mTOR) dual inhibitor
- FDG-PET of mouse breast cancers on ketogenic vs. standard chow diets, with or without added Rapamycin.
- Rapamycin enhanced autophagy favors tolerance induction in allotransplantation model through mTORC1/ULK1 pathway
- Collecting‐duct‐principal‐cell‐select knockout (KO) of the mechanistic‐target‐of‐Rapamycin (mTOR) alters sodium and acid/base homeostasis
- The Mammalian Target of Rapamycin Regulates Platelet Integrin Activation, Aggregation, and Ischemic Stroke
- Mammalian Target of Rapamycin (mTOR) Inhibitor Induced Pulmonary Alveolar Proteinosis
- Rapamycin affect the apoptosis of splenic CD4~+ CD25~+ regulatory T cells of mouse severe aplastic anemia model
- Safety and efficacy of conversion from calcineurin inhibitors to mammalian-target-of-Rapamycin inhibitors in liver transplant recipients: a meta-analysis of randomized …
- Promoter hypermethylation of Mammalian Target of Rapamycin Gene in Multiple Myeloma cells induced by curcumin
- Rapamycin Protects Against Myocardial Ischemia/Reperfusion Injury in Diabetic Mice Through Stat3-mir17/92 Signaling and Suppression of Prolyl Hydroxylase
- Rapamycin upregulates autophagy by inhibiting mTOR/P70S6K/4EBP1 signaling and reducing podocyte apoptosis
- The Mechanistic Target of Rapamycin (mTOR) and Its Complex 1 Associated Protein RPTOR are Germ Cell-autonomously Required for Spermatogonial Development …
- Mammalian target of Rapamycin (mTOR) and autophagy in hepatitis c virus-related hepatocellular carcinoma: relation to tumor progression
- Targeting the phosphatidylinositol 3-kinase/Akt/mechanistic target of Rapamycin (PI3K/Akt/mTOR) signaling pathway in B-lineage acute lymphoblastic leukemia
- … , Sirtuin1 and peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha, overactive mammalian target of Rapamycin, and dysregulated metabolites …
- MicroRNA-25 Modulates Proliferative Signaling Via the Mammalian Target of Rapamycin Pathway in Asthmatic Airway Smooth Muscle Cells In Vitro
- D-1: The TOR (Target of Rapamycin) pathway governs growth and stress response in C. neoformans
- The level of microRNA 21 is upregulated by Rapamycin in serum of tuberous sclerosis complex patients and subependymal giant cell astrocytoma (SEGA) …
- … : Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of Rapamycin complex 1 (mTORC1).
- Abstract P6-07-04: Rapamycin inhibits the stemness of mammary epithelial cells in the premalignant tissues of MMTV-ErbB2 transgenic mice
- Dysregulation of microRNA-25 Modulates Airway Smooth Muscle Cell Proliferation via the Mammalian Target of Rapamycin Pathway by Targeting Tuberous Sclerosis …
- Deficiency of Myocardial miR-17-92 Cluster Exacerbates Ischemic Injury and Abrogates Rapamycin-Induced Protection in Diabetic Mice
- HGG-16. SUSTAINED RESPONSE TO ERLOTINIB AND Rapamycin IN A PATIENT WITH PEDIATRIC ANAPLASTIC OLIGODENDROGLIOMA
- Clinical significance of microtubule-associated protein 1 light chain 3 and mammalian target of Rapamycin expression in oral leukoplakia in smokers and never …
- Mutational analysis and safety/efficacy in a phase 2 multi-center investigation of ABI-009 (nab-Rapamycin) in patients with advanced malignant perivascular …
- Abstract P1-07-27: Prognostic value of programmed death 1/Programmed death ligand 1/mammalian target of Rapamycin/Rictor/Tuberin in human breast cancer
- … with everolimus against advanced renal cell carcinoma by dual targeting of Akt/pyruvate kinaseM2 and mechanistic target of Rapamycin complex 1 pathways
- Low Dose IL-2 and Rapamycin Leads to Prolongation of Human Islet Allograft Survival by inhibition of IFN-gamma+ T cells and Expansion of FOXP3+ CD25+ Tregs in …
- … for optimal inhibition of colon cancer stem cells: Simultaneous inhibition of Insulin-like growth factor-1 receptor-AKT-mammalian target of Rapamycin axis and the …
- Antitumor activity of ABI-009 (nab-Rapamycin) in combination with anti-PD1 antibody in a syngeneic mouse model of B16 melanoma
- 4CPS-143 Topical application of Rapamycin 0.4% for treatment of facial angiokeratomas in a paediatric patient
- Defining the Properties of the OS-33 Osteosarcoma Cell Line and Effects of mTORC1 inhibition by Rapamycin
- A phase 1b investigation of safety/efficacy of nivolumab and ABI-009 (nab-Rapamycin) in advanced undifferentiated pleomorphic sarcoma (UPS), liposarcoma (LPS) …
- … IN HEPATOCELLULAR CARCINOMA-29 CELLS AFTER SEPARATE AND COMBINED ADMINISTRATION OF LITHIUM CARBONATE AND Rapamycin
- … Is Dentin Sensitivity: Effect of an Experimental Desensitizing Agent on Stomatitis: Stomatitis Associated With Mammalian Target of Rapamycin inhibition: A Review of …
- Target of Rapamycin signaling in plant stress responses
- Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor Rapamycin
- The mechanistic target of Rapamycin (mTOR): novel considerations as an antiviral treatment
- Rapamycin rejuvenates oral health in aging mice
- Rapamycin-loaded biomimetic nanoparticles reverse vascular inflammation
- Effect of Rapamycin on aging and age-related diseases—past and future
- Brain protein synthesis rates in the UM-HET3 mouse following treatment with Rapamycin or Rapamycin with metformin
- Is Rapamycin a dietary restriction mimetic?
- Exaptive evolution of target of Rapamycin signaling in multicellular eukaryotes
- Targeting T-cell senescence and cytokine storm with Rapamycin to prevent severe progression in COVID-19
- The target of Rapamycin signalling pathway in ageing and lifespan regulation
- Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment
- Commentary: Rapamycin for the aging skin
- Differential effects of Rapamycin and metformin in combination with Rapamycin on mechanisms of proteostasis in cultured skeletal myotubes
- Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by Methionine
- Rationally designed Rapamycin-encapsulated ZIF-8 nanosystem for overcoming chemotherapy resistance
- Mechanistic target of Rapamycin regulates the oligodendrocyte cytoskeleton during myelination
- Mechanistic target of Rapamycin in the tumor microenvironment and its potential as a therapeutic target for pancreatic cancer
- The regulation of Rapamycin on nutrient metabolism in Nile tilapia fed with high-energy diet
- Mechanistic target of Rapamycin signaling in mouse models of accelerated aging
- Cannabidiol elevates mechanistic target of Rapamycin inhibitor levels in patients with tuberous sclerosis complex
- Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis
- Rapamycin induces morphological and physiological changes without increase in lipid content in Ustilago maydis
- Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19
- APOE genotype-dependent pharmacogenetic responses to Rapamycin for preventing Alzheimer’s disease
- Luteolin suppresses bladder cancer growth via regulation of mechanistic target of Rapamycin pathway
- Targeting mammalian target of Rapamycin: prospects for the treatment of inflammatory bowel diseases
- Treatment with Rapamycin can restore regulatory T-cell function in IPEX patients
- Rapamycin maintains NAD+/NADH redox homeostasis in muscle cells
- TARGET OF Rapamycin signaling plays a role in Arabidopsis growth promotion by Azospirillum brasilense Sp245
- Rapamycin promotes endothelial–mesenchymal transition during stress-induced premature senescence through the activation of autophagy
- Rapamycin treatment correlates changes in primary cilia expression with cell cycle regulation in epithelial cells
- The anticancer effects of curcumin via targeting the mammalian target of Rapamycin complex 1 (mTORC1) signaling pathway
- Enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by Rapamycin-sensitive mTOR complex 1 inhibition
- Lowe syndrome patient cells display mTOR-and RhoGTPase-dependent phenotypes alleviated by Rapamycin and statins
- Cognitive impairment with diabetes mellitus and metabolic disease: innovative insights with the mechanistic target of Rapamycin and circadian clock gene pathways
- Targeted pathological collagen delivery of sustained-release Rapamycin to prevent heterotopic ossification
- The plant target of Rapamycin: a conduc TOR of nutrition and metabolism in photosynthetic organisms
- The effect of Rapamycin on bovine oocyte maturation success and metaphase telomere length maintenance
- Rapamycin regulates the balance between cardiomyocyte apoptosis and autophagy in chronic heart failure by inhibiting mTOR signaling
- Rapamycin affects palmitate-induced lipotoxicity in osteoblasts by modulating apoptosis and autophagy
- Effects of Rapamycin and AZD3463 combination on apoptosis, autophagy, and cell cycle for resistance control in breast cancer
- Rapamycin attenuates the paraquat‐induced pulmonary fibrosis through activating Nrf2 pathway
- Metformin rescues Rapamycin-induced mitochondrial dysfunction and attenuates rheumatoid arthritis with metabolic syndrome
- Discovery of a brain-penetrant ATP-competitive inhibitor of the mechanistic target of Rapamycin (mTOR) for CNS disorders
- Rapamycin preserves the primordial follicle pool during cisplatin treatment in vitro and in vivo
- Wide electrochemical window of screen-printed electrode for determination of Rapamycin using ionic liquid/graphene composites
- The mechanistic target of Rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation
- Target of Rapamycin regulates potassium uptake in Arabidopsis and potato
- Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound
- Rapidly dissolving microneedles for the delivery of cubosome-like liquid crystalline nanoparticles with sustained release of Rapamycin
- Target of Rapamycin signaling is tightly and differently regulated in the plant response under distinct abiotic stresses
- Metabolite regulatory interactions control plant respiratory metabolism via Target of Rapamycin (TOR) kinase activation
- Target of Rapamycin regulates genome methylation reprogramming to control plant growth in Arabidopsis
- Linc‐ROR promotes the progression of breast cancer and decreases the sensitivity to Rapamycin through miR‐194‐3p targeting MECP2
- Nanotoxicology of an Elastin-like Polypeptide Rapamycin Formulation for Breast Cancer
- Transdermal delivery of Rapamycin with poor water-solubility by dissolving polymeric microneedles for anti-angiogenesis
- Rapamycin relieves the cataract caused by ablation of Gja8b through stimulating autophagy in zebrafish
- Functional analysis target of Rapamycin (TOR) on the Penaeus vannamei in response to acute low temperature stress
- Rapamycin and hydroxychloroquine combination alters macrophage polarization and sensitizes glioblastoma to immune checkpoint inhibitors
- Deregulated mTOR (mechanistic target of Rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development
- Radiosensitising cancer using Phosphatidylinositol-3-Kinase (PI3K), Protein Kinase B (AKT) or mammalian target of Rapamycin (mTOR) Inhibitors
- Rapamycin inhibits pathogen transmission in mosquitoes by promoting immune activation
- Inflammation‐induced mammalian target of Rapamycin signaling is essential for retina regeneration
- Targeting mechanistic target of Rapamycin complex 1 restricts proinflammatory T cell differentiation and ameliorates Takayasu arteritis
- Unlike dietary restriction, Rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice
- Target Of Rapamycin pathway in the white-rot fungus Phanerochaete chrysosporium
- Rapamycin and mTORC2 inhibition synergistically reduce contraction‐stimulated muscle protein synthesis
- Upregulation of Akt/Raptor signaling is associated with Rapamycin resistance of breast cancer cells
- PKC downregulation upon Rapamycin treatment attenuates mitochondrial disease
- Microalgal Target of Rapamycin (TOR): A Central Regulatory Hub for Growth, Stress Response and Biomass Production
- Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or Rapamycin
- Rapamycin treatment maintains developmental potential of oocytes in mice and follicle reserve in human cortical fragments grafted into immune-deficient mice
- Fpr1, a primary target of Rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae
- Inhaled Rapamycin solid lipid nano particles for the treatment of Lymphangioleiomyomatosis
- Rapamycin and MCC950 modified gut microbiota in experimental autoimmune encephalomyelitis mouse by brain gut axis
- TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and Rapamycin-induced MNK-eIF4E signaling
- Mechanistic Target of Rapamycin Signaling Activation Antagonizes Autophagy To Facilitate Zika Virus Replication
- The efficacy and safety of topical Rapamycin–calcitriol for facial angiofibromas in patients with tuberous sclerosis complex: a prospective, double‐blind, randomized …
- Rapamycin–PLGA microparticles prevent senescence, sustain cartilage matrix production under stress and exhibit prolonged retention in mouse joints
- Sirolimus and other mechanistic target of Rapamycin inhibitors directly activate latent pathogenic human polyomavirus replication
- Angiotensin-converting enzyme inhibitor rapidly ameliorates depressive-type behaviors via bradykinin-dependent activation of mammalian target of Rapamycin …
- Nanoporous Gold Monolith for High Loading of Unmodified Doxorubicin and Sustained Co-Release of Doxorubicin-Rapamycin
- An exploratory study of metformin with or without Rapamycin as maintenance therapy after induction chemotherapy in patients with metastatic pancreatic …
- Low‐dose Rapamycin‐induced autophagy in cochlear outer sulcus cells
- Mammalian Target of Rapamycin Complex 2 Signaling Is Required for Liver Regeneration in a Cholestatic Liver Injury Murine Model
- mTOR Mysteries: Nuances and Questions About the Mechanistic Target of Rapamycin in Neurodegeneration
- Supply of methionine and arginine alters phosphorylation of mechanistic target of Rapamycin (mTOR), circadian clock proteins, and α-s1-casein abundance in …
- The mammalian target of Rapamycin (mTOR) kinase mediates haloperidol-induced cataleptic behavior
- Rapamycin extends life span in ApcMin/+ colon cancer FAP model
- Advances in mammalian target of Rapamycin kinase inhibitors: application to devices used in the treatment of coronary artery disease
- Effects of glycosylation on the bioactivity of Rapamycin
- Rapamycin inhibits Nf-ΚB activation by autophagy to reduce catabolism in human chondrocytes
- Mitochondrial spongiotic brain disease: astrocytic stress and harmful Rapamycin and ketosis effect
- Target of Rapamycin signaling inhibits autophagy in sea cucumber Apostichopus japonicus
- Bioproperties, Nanostructured System and Analytical and Bioanalytical Methods for Determination of Rapamycin: A Review
- Short-and long-term effects of Rapamycin on ischemic damage and apoptotic changes in torsion of rat testes
- Therapeutic effects of Rapamycin and surgical decompression in a rabbit spinal cord injury model
- Effects of Rapamycin Combined with Cisplatin on Tumor Necrosis Factor TNF-α in MG-63 Cells
- Sex differences in changes of protein synthesis with Rapamycin treatment are minimized when metformin is added to Rapamycin
- Inhibitory efficacy of Rapamycin against potato white mold
- Gene transfer in adeno-associated virus seropositive rhesus macaques following Rapamycin treatment and subcutaneous delivery of AAV6, but not retargeted AAV6 …
- Wheat Germination Is Dependent on Plant Target of Rapamycin Signaling
- Differential roles and activation of mammalian target of Rapamycin complexes 1 and 2 during cell migration in prostate cancer cells
- Dietary and Pharmacological Interventions That Inhibit Mammalian Target of Rapamycin Activity Alter the Brain Expression Levels of Neurogenic and Glial Markers in …
- Rapamycin increases the incidence of neuropsychiatric illness in kidney transplant patients through the suppression of neural stem cells
- Roles of the mammalian target of Rapamycin (mTOR) signaling pathway in the repair of hyperoxia-induced acute lung injury.
- Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects
- Mammalian target of Rapamycin-RhoA signaling impairments in direct striatal projection neurons induce altered behaviors and striatal physiology in mice
- The mTOR inhibitor Rapamycin prevents general anesthesia-induced changes in synaptic transmission and mitochondrial respiration in late postnatal mice
- Low nitrogen induces root elongation via auxin-induced acid growth and auxin-regulated target of Rapamycin (TOR) pathway in maize
- Resveratrol potentiates the anti-tumor effects of Rapamycin in papillary thyroid cancer: PI3K/AKT/mTOR pathway involved
- … analysis of neonatal regenerative myocardium revealed important roles of checkpoint kinase 1 via activating mammalian target of Rapamycin C1/Ribosomal protein …
- Epidermal mammalian target of Rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation
- Lithium chloride combination with Rapamycin for the treatment of COVID-19 pneumonia
- Dendrimer-Mediated Targeted Delivery of Rapamycin to Tumor-Associated Macrophages Improves Systemic Treatment of Glioblastoma
- PD-L1 cellular nanovesicles carrying Rapamycin inhibit alloimmune responses in transplantation
- Melatonin regulates the ovarian function and enhances follicle growth in aging laying hens via activating the mammalian target of Rapamycin pathway
- Acetate regulates milk fat synthesis through the mammalian target of Rapamycin/eukaryotic initiation factor 4E signaling pathway in bovine mammary epithelial cells
- Neurobehavioral effects in rats with experimentally induced glioblastoma after treatment with the mTOR-inhibitor Rapamycin
- Short-Term Rapamycin Preconditioning Diminishes Therapeutic Efficacy of Human Adipose-Derived Stem Cells in a Murine Model of Multiple Sclerosis
- Intralacrimal Sustained Delivery of Rapamycin Shows Therapeutic Effects without Systemic Toxicity in a Mouse Model of Autoimmune Dacryoadenitis Characteristic of …
- Fibro-adipose vascular anomaly (FAVA): three case reports with an emphasis on the mammalian target of Rapamycin (mTOR) pathway
- DNA-and telomere-damage does not limit lifespan: evidence from Rapamycin
- Spermidine and Rapamycin Reveal Distinct Autophagy Flux Response and Cargo Receptor Clearance Profile
- Properties of Rapamycin solid lipid nanoparticles for lymphatic access through the lungs & part I: the effect of size
- Transient and late-life Rapamycin for healthspan extension
- Role of the Mammalian Target of Rapamycin Pathway in Liver Cancer: From Molecular Genetics to Targeted Therapies
- Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, Rapamycin
- Rapamycin restrains platelet procoagulant responses via FKBP-mediated protection of mitochondrial integrity
- Hypothalamic orexin and mechanistic target of Rapamycin activation mediate sleep dysfunction in a mouse model of tuberous sclerosis complex
- Rapamycin Plus Vildagliptin to Recover β-Cell Function in Long-Standing Type 1 Diabetes: A Double-Blind, Randomized Trial
- Differential Effects of Rapamycin on Glucose Metabolism in Nine Inbred Strains
- The effect of a ketogenic diet and synergy with Rapamycin in a mouse model of breast cancer
- inhibition of mechanistic target of Rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta
- Implications of maraviroc and/or Rapamycin in a mouse model of fragility
- Properties of Rapamycin solid lipid nanoparticles for lymphatic access through the lungs & part II: the effect of nanoparticle charge
- Potential new therapy of Rapalink‐1, a new generation mammalian target of Rapamycin inhibitor, against sunitinib‐resistant renal cell carcinoma
- Visualizing protein-protein interactions in plants by Rapamycin-dependent delocalization
- Mmi1, the yeast ortholog of mammalian translationally controlled tumor protein (TCTP), negatively affects Rapamycin-induced autophagy in post-diauxic growth phase
- Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients
- … expression of activator proteins that control follicle reserve after ovarian tissue cryopreservation/transplantation and primordial follicle loss prevention by Rapamycin
- Pharmacophore-guided fragment-based design of novel mammalian target of Rapamycin inhibitors: extra precision docking, fingerprint-based 2D and atom-based 3D …
- The Release of cyclophilin a from Rapamycin-stimulated vascular smooth muscle cells mediated by myosin ii activation: involvement of apoptosis but not autophagy
- Mechanistic target of Rapamycin kinase (mTOR) is required for spermatogonial proliferation and differentiation in mice
- A Novel Combination Treatment with Honokiol and Rapamycin Effectively Restricts c-Met-Induced Growth of Renal Cancer Cells, and also Inhibits the Expression of …
- Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of Rapamycin …
- Rapamycin inhibits B-cell activating factor (BAFF)-stimulated cell proliferation and survival by suppressing Ca2+-CaMKII-dependent PTEN/Akt-Erk1/2 signaling …
- Thioredoxin-1 maintains mitochondrial function via mechanistic target of Rapamycin signalling in the heart
- Azospirillum brasilense Sp245 lipopolysaccharides induce target of Rapamycin signaling and growth in Arabidopsis thaliana
- Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy
- … of Autophagy in Glioblastoma Treatment With Phosphoinositide 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway Inhibitors
- Mammalian target of Rapamycin and p70S6K mediate thrombin-induced nuclear factor-κB activation and IL-8/CXCL8 release in human lung epithelial cells
- Resveratrol, Rapamycin and Metformin as Modulators of Antiviral Pathways
- Effects of Rapamycin on osteosarcoma cell proliferation and apoptosis by inducing autophagy
- Rapamycin for aging stem cells
- Rapamycin: Drug Repurposing in SARS-CoV-2 Infection
- Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients
- Target of Rapamycin (TOR) negatively regulates ethylene signals in Arabidopsis
- inhibition of the mechanistic target of Rapamycin induces cell survival via MAPK in tuberous sclerosis complex
- Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTOR Signalling in the Liver
- Structural insights into CYP107G1 from Rapamycin-producing Streptomyces Rapamycinicus
- Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence
- Genetically encoded biosensors for the detection of Rapamycin: toward the screening of agonists and antagonists
- B Cell Depletion Eliminates FVIII Memory B Cells and Enhances AAV8-coF8 Immune Tolerance Induction When Combined With Rapamycin
- Rapamycin, by Inhibiting mTORC1 Signaling, Prevents the Loss of Striatal Bidirectional Synaptic Plasticity in a Rat Model of L-DOPA-Induced Dyskinesia
- Rapamycin Induces an eNOS (Endothelial Nitric Oxide Synthase) Dependent Increase in Brain Collateral Perfusion in Wistar and Spontaneously Hypertensive Rats
- mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo
- Mitochondrial dysfunction contributes to Rapamycin-induced apoptosis of Human Glioblastoma Cells-A synergistic effect with Temozolomide
- Rapamycin Promotes Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells in a Stage-Dependent Manner
- Rapamycin and abundant TCR stimulation are required for the generation of stable human induced regulatory T cells
- Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling
- Rapamycin-Loaded mPEG-PLGA Nanoparticles Ameliorate Hepatic Steatosis and Liver Injury in Non-alcoholic Fatty Liver Disease
- Interactions of FK506 and Rapamycin With FK506 Binding Protein 12 in Opportunistic Human Fungal Pathogens
- Rapamycin-loaded lipid nanocapsules induce selective inhibition of the mTORC1-signaling pathway in glioblastoma cells
- Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of Rapamycin pathway
- Copper induces hepatocyte autophagy via the mammalian targets of the Rapamycin signaling pathway in mice
- Rapamycin and dexamethasone during pregnancy prevent tuberous sclerosis complex–associated cystic kidney disease
- Effects of mammalian target of Rapamycin inhibitors on fibrosis after trabeculectomy
- Phase I Trial of Encapsulated Rapamycin in Prostate Cancer Patients Under Active Surveillance to Prevent Progression
- SFCE-RAPIRI Phase I Study of Rapamycin Plus Irinotecan: A New Way to Target Intra-Tumor Hypoxia in Pediatric Refractory Cancers
- Effect of Rapamycin on repeated immobilization stress-induced immune alterations in the rat spleen
- Reduction of FoxP3+ Tregs by an immunosuppressive protocol of Rapamycin plus Thymalfasin and Huaier extract predicts positive survival benefits in a rat …
- The Rapamycin analog Everolimus reversibly impairs male germ cell differentiation and fertility in the mouse
- Protective Effects of Rapamycin on Trabecular Meshwork Cells in Glucocorticoid-Induced Glaucoma Mice
- Insulin potentiates essential amino acids effects on mechanistic target of Rapamycin complex 1 signaling in MAC-T cells
- Mechanistic target of Rapamycin-mediated autophagy is involved in the alleviation of lipopolysaccharide-induced acute lung injury in rats
- Rapamycin alleviates renal damage in mice with systemic lupus erythematosus through improving immune response and function
- Rapamycin inhibits lung squamous cell carcinoma growth by downregulating glypican-3/Wnt/β-catenin signaling and autophagy
- Mammalian target of Rapamycin (mTOR) inhibitors and skin cancer risk in nonrenal solid organ transplant recipients: systematic review and meta‐analysis
- Effect of mechanistic/mammalian target of Rapamycin complex 1 on mitochondrial dynamics during skeletal muscle hypertrophy
- Rictor promotes tumor progression of Rapamycin-insensitive triple-negative breast cancer cells
- Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells
- Novel brain permeant mTORC1/2 inhibitors are as efficacious as Rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis …
- Topical administration of Rapamycin promotes retinal ganglion cell survival and reduces intraocular pressure in a rat glaucoma model
- MYC‐binding lncRNA EPIC1 promotes AKT‐mTORC1 signaling and Rapamycin resistance in breast and ovarian cancer
- Human monocyte-derived macrophage responses to M. tuberculosis differ by the host’s tuberculosis, diabetes or obesity status, and are enhanced by Rapamycin
- … RNA 0152 promotes hepatocellular carcinoma progression by regulating phosphatidylinositol 3-Kinase/Akt/mammalian target of Rapamycin signaling pathway through …
- Optimized Rapamycin-loaded PEGylated PLGA nanoparticles: Preparation, characterization and pharmacokinetics study
- Modulatory effect of Rapamycin and tacrolimus on monocyte-derived dendritic cells phenotype and function
- Rapamycin improves renal injury induced by Iodixanol in diabetic rats by deactivating the mTOR/p70S6K signaling pathway
- Rapamycin inhibits AR signaling pathway in prostate cancer by interacting with the FK1 domain of FKBP51
- … angiogenic function of human lung microvascular endothelial cells via LAT1 (L-type amino acid transporter 1)-mediated mTOR (Mammalian Target of Rapamycin) …
- Rapamycin Reduces Cervical Cancer Cells Viability in Hypoxic Condition: Investigation of the Role of Autophagy and Apoptosis
- Proteasome activity and expression of mammalian target of Rapamycin signaling factors in skeletal muscle of dairy cows supplemented with conjugated linoleic acids …
- In Silico Strategy for Targeting the mTOR Kinase at Rapamycin Binding Site by Small Molecules
- Metastatic role of mammalian target of Rapamycin signaling activation by chemoradiotherapy in advanced rectal cancer
- Chloroquine and Rapamycin Augment Interleukin-37 Expression via the LC3, ERK, and AP-1 Axis in the Presence of Lipopolysaccharides
- Gemcitabine and Rapamycin Exhibit Additive Effect against Osteosarcoma by Targeting Autophagy and Apoptosis
- … Study of Immunomodulatory Agents to Induce Human T Regulatory (Treg) Cells: Preferential Treg-Stimulatory Effect of Prednisolone and Rapamycin
- Rapamycin Inhibitors for Eye Squamous Cell Carcinoma after Renal Transplantation: A Case Report
- Autophagy induction by Rapamycin ameliorates experimental colitis and improves intestinal epithelial barrier function in IL-10 knockout mice
- A high-dose Rapamycin treatment alleviates hepatopulmonary syndrome in cirrhotic rats
- Antifungal activity of Rapamycin on Botryosphaeria dothidea and its effect against Chinese hickory canker
- Protective effects of glucagon‐like peptide‐1 on cardiac remodeling by inhibiting oxidative stress through mammalian target of Rapamycin complex 1/p70 ribosomal …
- Toxicity Evaluation of a Novel Rapamycin Liposomal Formulation After Subconjunctival and Intravitreal Injection
- Results of a phase Ib trial of encapsulated Rapamycin in prostate cancer patients under active surveillance to prevent progression.
- Limited efficacy of Rapamycin monotherapy in vascularized composite allotransplantation
- inhibition of the mammalian target or Rapamycin (mTOR): a potential therapeutic strategy for multiple system atrophy
- HIF-1α-Mediated Telomerase Reverse Transcriptase Activation Inducing Autophagy Through Mammalian Target of Rapamycin Promotes Papillary Thyroid Carcinoma …
- Rapamycin Ameliorates Cognitive Impairments and Alzheimer’s Disease-Like Pathology with Restoring Mitochondrial Abnormality in the Hippocampus of …
- Rapamycin-Induced Autophagy Promotes the Chondrogenic Differentiation of Synovium-Derived Mesenchymal Stem Cells in the Temporomandibular Joint in …
- Tacrolimus, a Rapamycin target protein inhibitor, exerts anti-cystic echinococcosis effects both in vitro and in vivo
- Mammalian target of Rapamycin inhibitors after post-transplant hepatocellular carcinoma recurrence: Is it too late?
- Proteomics Approach of Rapamycin Anti-Tumoral Effect on Primary and Metastatic Canine Mammary Tumor Cells In Vitro
- Rapamycin Improves Recognition Memory and Normalizes Amino-Acids and Amines Levels in the Hippocampal Dentate Gyrus in Adult Rats Exposed to Ethanol …
- Exosomes secreted from mesenchymal stem cells mediate the regeneration of endothelial cells treated with Rapamycin by delivering pro-angiogenic microRNAs
- Rapamycin is Effective for Upper but not for Lower Gastrointestinal Crohn’s Disease-Related Stricture: A Pilot Study
- Upregulation of 6‐phosphofructo‐2‐kinase (PFKFB3) by hyperactivated mammalian target of Rapamycin complex 1 is critical for tumor growth in tuberous sclerosis …
- mTORC1 (Mechanistic Target of Rapamycin Complex 1) Signaling in Endothelial and Smooth Muscle Cells Is Required for Vascular Function
- The mTORC1 inhibitor Rapamycin and the mTORC1/2 inhibitor AZD2014 impair the consolidation and persistence of contextual fear memory
- Rapamycin could increase the effects of melatonin against age-dependent bone loss
- Chronic low-dose Rapamycin treatment fine tunes cardioprotective signalling in ischaemia-reperfused diabetic hearts
- Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4+ CD25+ FOXP3+ Regulatory T Cells and Prolonged Human Islet Allograft Survival in …
- Rapamycin alleviates cognitive impairment in murine vascular dementia: The enhancement of mitophagy by PI3K/AKT/mTOR axis
- … sensors and reproductive hypothalamo-pituitary ovarian axis (HPO) in female mammals: role of mTOR (mammalian target of Rapamycin), AMPK (AMP-activated …
- Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes
- Blockade of the mTOR signaling pathway with Rapamycin ameliorates aristolochic acid nephropathy
- STAT3-miR-17/20 signalling axis plays a critical role in attenuating myocardial infarction following Rapamycin treatment in diabetic mice
- Adiponectin receptor 1 variants contribute to hypertrophic cardiomyopathy that can be reversed by Rapamycin
- Activation of the Akt/mammalian target of Rapamycin pathway in combined hepatocellular carcinoma and cholangiocarcinoma: significant correlation between p-4E …
- Topical Rapamycin versus betamethasone dipropionate ointment for treating oral erosive lichen planus: a randomized, double‐blind, controlled study
- Rapamycin Alleviates the Symptoms of Multiple Sclerosis in Experimental Autoimmune Encephalomyelitis (EAE) Through Mediating the TAM-TLRs-SOCS …
- Rapamycin‐based graft‐versus‐host disease prophylaxis increases the immunosuppressivity of myeloid‐derived suppressor cells without affecting T cells and anti …
- Rapamycin Protects Skin Fibroblasts From UVA-Induced Photoaging by inhibition of p53 and Phosphorylated HSP27
- Rapamycin synergizes the cytotoxic effects of MEK inhibitor binimetinib and overcomes acquired resistance to therapy in melanoma cell lines in vitro
- Effects of co-administration of Rapamycin and evening primrose/hemp seed oil supplement on immunologic factors and cell membrane fatty acids in experimental …
- Sirt4 Modulates Oxidative Metabolism and Sensitivity to Rapamycin Through Species-Dependent Phenotypes in Drosophila mtDNA Haplotypes
- NEAT1/hsa-miR-372-3p axis participates in Rapamycin-induced lipid metabolic disorder
- Comparison of Two Strategies Based On Mammalian Target of Rapamycin Inhibitors In Secondary Prevention of Non‐Melanoma Skin Cancer After Kidney …
- Correction: An ATP-competitive mammalian target of Rapamycin inhibitor reveals Rapamycin-resistant functions of mTORC1.
- … replacement with composite mixture of shrimp hydrolysate and plant proteins on growth performance, feed utilization, and target of Rapamycin pathway in largemouth …
- … amino acid transporter: Sodium-coupled neutral amino acid transporter 2 inhibits cell growth and mammalian target of Rapamycin complex 1 pathway in …
- Metformin and Rapamycin protect cells from vital dye–induced damage in retinal pigment epithelial cells and in vivo
- Rapamycin Preserves Neural Tissue, Promotes Schwann Cell Myelination and Reduces Glial Scar Formation After Hemi-Contusion Spinal Cord Injury in Mice
- Persistent myopathy despite release of partial obstruction: in vivo reversal of dysfunction and transcriptional responses using Rapamycin
- Exercise intervention attenuates neuropathic pain in diabetes via mechanisms of mammalian target of Rapamycin (mTOR)
- Role of exercise and Rapamycin on the expression of energy metabolism genes in liver tissues of rats fed a high‑fat diet
- The protective effects of Rapamycin pretreatment on ovarian damage during ovarian tissue cryopreservation and transplantation
- Characteristics of Lymphedema in Patients Treated with Mammalian Target of Rapamycin Inhibitors
- Protective effects of Rapamycin on the retinal vascular bed during the vaso‐obliteration phase in mouse oxygen‐induced retinopathy model
- Rapamycin Alleviates Hypertriglyceridemia-Related Acute Pancreatitis via Restoring Autophagy Flux and Inhibiting Endoplasmic Reticulum Stress
- Microvessel density and vascular endothelial growth factor receptors in breast carcinoma under the influence of Rapamycin and platelet factor 4
- Mitochondrial General Control of Amino Acid Synthesis 5 Like 1 Regulates Glutaminolysis, Mammalian Target of Rapamycin Complex 1 Activity, and Murine Liver …
- Matrix-assisted pulsed laser evaporation-deposited Rapamycin thin films maintain antiproliferative activity
- The Effectiveness of Rapamycin Combined with Eltrombopag in Murine Models of Immune-Mediated Bone Marrow Failure
- Rapamycin induces megakaryocytic differentiation through increasing autophagy in Dami cells
- Comprehensive Analysis of the Immunomodulatory Effects of Rapamycin on Human T Cells in Graft‐versus‐Host Disease Prophylaxis
- Tumor Susceptibility Gene 101 facilitates Rapamycin-induced autophagic flux in neuron cells
- FTY720 Suppresses Liver Tumor Growth and Metastasis by Reducing Circulating Regulating T Cells and Enhancing the Anti-Tumor Effect of Rapamycin
- Oral Preconditioning of Donors After Brain Death With Calcineurin Inhibitors vs. Inhibitors of Mammalian Target for Rapamycin in Pig Kidney Transplantation
- Polymeric nanoparticles containing Rapamycin and autoantigen induce antigen-specific immunological tolerance for preventing vitiligo in mice
- Rapamycin enhances BCG-specific γδ T cells during intravesical BCG therapy for non-muscle invasive bladder cancer: a randomized, double-blind study
- Ultrasound Stimulation Increases Neurite Regeneration in Injured Dorsal Root Ganglion Neurons through Mammalian Target of Rapamycin Activation
- Target of Rapamycin in Control of Autophagy: Puppet Master and Signal Integrator
- Synergistic Effect of 3-Bromopyruvate in Combination with Rapamycin Impacted Neuroblastoma Metabolism by Inhibiting Autophagy
- Role of mechanistic target of Rapamycin and autophagy in alcohol-induced adipose atrophy and liver injury
- Targeted inhibition of the epidermal growth factor receptor and mammalian target of Rapamycin signaling pathways in olmsted syndrome
- … by chemokine (cc motif) ligand 3 promote the progression of breast cancer via phosphoinositide 3-kinase-protein kinase b-mammalian target of Rapamycin …
- Retraction: Rapamycin Inhibits Proliferation of Hemangioma Endothelial Cells by Reducing HIF-1-Dependent Expression of VEGF
- … sensor based on carbon paste electrode modified with polypyrrole/multi‐walled carbon nanotubes for the electrochemical detection of cytostatic drug Rapamycin
- Comparison of Rapamycin and methylprednisolone for treating inflammatory muscle disease in a murine model of experimental autoimmune myositis
- Low Dose IL-2 Combined with Rapamycin Led to an Expansion of CD4+ CD25+ FOXP3+ Tregs and Prolonged Human Islet-allograft Survival in Humanized Mice
- Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1β and IL-18 in the Septic Response
- Methionine controls insulin/mammalian target of Rapamycin complex 1 activity by modulating tuberous sclerosis complex 2 stability
- Reactive Oxygen Species‐Scavenging Scaffold with Rapamycin for Treatment of Intervertebral Disk Degeneration
- Cell synchronization by Rapamycin improves the developmental competence of buffalos (Bubalus bubalis) somatic cell nuclear transfer embryos
- Therapeutic Effect of Rapamycin on Aortic Dissection in Mice
- Rapamycin inhibits proliferation and apoptosis of retinoblastoma cells through PI3K/AKT signaling pathway
- Rapamycin-dependent delocalization as a novel tool to reveal protein-protein interactions in plants
- … Membrane Cassette Transport Protein A1 via Adenosine Monophosphate-Activated Protein Kinase/Mammalian Target of Rapamycin Signaling in Macrophages
- Protective effect of Rapamycin against acrylamide‐induced hepatotoxicity: The associations between autophagy, apoptosis, and necroptosis
- Physiological function of FKBP12, a primary target of Rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast
- Sustained response to erlotinib and Rapamycin in a patient with pediatric anaplastic oligodendroglioma
- Dermatological adverse events associated with use of oral mechanistic target of Rapamycin inhibitors in a cohort of individuals with tuberous sclerosis complex
- Porcine circovirus 3 capsid protein induces autophagy in HEK293T cells by inhibiting phosphorylation of the mammalian target of Rapamycin
- Use of topical Rapamycin in acral pseudolymphomatous angiokeratoma of children (APACHE): A report of two cases and review of the literature
- Rapamycin (sirolimus) in treatment of recurrent intravenous leiomyomatosis: a case report
- Genes responsive to Rapamycin and serum deprivation are clustered on chromosomes and undergo reorganization within local chromatin environments
- Short-term oral Rapamycin prevents age-related learning impairment in mice
- … in plant‐rich diets affects growth, feed utilization, body composition, blood biochemical indices and gene expressions of the target of Rapamycin signaling pathway in …
- Investigation of the effects of Rapamycin on the mTOR pathway and apoptosis in metastatic and non-metastatic human breast cancer cell lines
- Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer
- Rapamycin and 3-Methyladenine Influence the Apoptosis, Senescence, and Adipogenesis of Human Adipose-Derived Stem Cells by Promoting and Inhibiting …
- Rapamycin-Preactivated Autophagy Enhances Survival and Differentiation of Mesenchymal Stem Cells After Transplantation into Infarcted Myocardium
- S100A8 and S100A9 promote endothelial cell activation through the RAGE‑mediated mammalian target of Rapamycin complex 2 pathway
- Rapamycin Pretreatment Alleviates Cerebral Ischemia/Reperfusion Injury in Dose-Response Manner Through inhibition of the Autophagy and NFκB Pathways in Rats
- Metabolic and Renal Effects of Mammalian Target of Rapamycin Inhibitors Treatment After Liver Transplantation: Real-Life Single-Center Experience
- Use of Topical Sirolimus (Rapamycin) for Treating Confluent and Reticulated Papillomatosis
- The Antidiabetic Agent Acarbose Improves Anti-PD-1 and Rapamycin Efficacy in Preclinical Renal Cancer
- Effect and mechanism of Rapamycin on proliferation and apoptosis of human lung cancer cells
- Iron Overload Impairs Autophagy: Effects of Rapamycin in Ameliorating Iron-Related Memory Deficits
- Scopoletin Activates Adenosine Monophosphate-Activated Protein Kinase/Mammalian Target of Rapamycin Signaling Pathway and Improves Functional Recovery …
- … Cancer Progression Through Directly Targeting Phosphatidylinositol 5‐Phosphate 4‐Kinase Type‐2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling …
- Role of Akt and mammalian target of Rapamycin signalling in insulin-like growth factor 1-mediated cell proliferation in porcine Sertoli cells
- Rapamycin prevents retinal neovascularization by downregulation of cyclin D1 in a mouse model of oxygen-induced retinopathy
- … -like peptide-1 alleviates diabetic kidney disease through activation of autophagy by regulating AMP-activated protein kinase-mammalian target of Rapamycin pathway
- … Acid Receptor 5 (LPAR5) Plays a Significance Role in Papillary Thyroid Cancer via Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin …
- Growth inhibition and suppression of the mTOR and Wnt/β‐catenin pathways in T‐acute lymphoblastic leukemia by Rapamycin and MYCN depletion
- Effect of Rapamycin on the Radio-Sensitivity of Cultured Tumor Cells Following Boron Neutron Capture Reaction
- Target of Rapamycin: function in abiotic stress tolerance in Arabidopsis and its involvement in a possible cross-talk with ribosomal proteins
- … /reperfusion injury by targeting connective tissue growth factor through the adenosine 5′-monophosphate-activated protein kinase/mammalian target of Rapamycin …
- Topical Rapamycin for acanthosis nigricans in the Fitzpatrick IV/V adolescent population
- Balancing Growth and Defense: Role of Target of Rapamycin and SNF1‐Related Protein Kinase 1 in Stress Signaling in Plants
- … Disease by Inhibiting Apoptosis and Promoting Autophagy via Reactive Oxygen Species/Phosphatidylinositol 3-Kinase/AKT/Mammalian Target of Rapamycin …
- … to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin …
- … Cell Proliferation and Progression of Lung Adenocarcinoma and Involves the Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin …
- Rapamycin Overproduction by Combined Mutational Study
- A systematic review and meta-analysis protocol of clinical characteristics and prognostic significance of mammalian target of Rapamycin for gastric cancer …
- Rapamycin Treatment Reduces Acute Myocarditis Induced by Trypanosoma cruzi Infection
- CLINICAL-EXPERIMENTAL EXPERIENCE WITH Rapamycin IN VISCERAL TRANSPLANTATION
- Rapamycin Eyedrops Increased CD4+ Foxp3+ Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface
- Chronic Mechanistic Target of Rapamycin inhibition: Preventing Cancer to Delay Aging or Vice Versa?
- Down-Regulation of the Mammalian Target of Rapamycin (mTOR) Pathway Mediates the Effects of the Paeonol-Platinum (II) Complex in Human Thyroid …
- Mammalian Target of Rapamycin Signaling Enhances Ovalbumin-Induced Neutrophilic Airway Inflammation By Promoting Th17 Cell Polarization in Murine …
- Arenobufagin Inhibits the Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Pathway and Induces Apoptosis and Autophagy in …
- CARDIOVASCULAR OUTCOMES OF Rapamycin-BASED IMMUNOSUPPRESSION IN KIDNEY TRANSPLANT RECIPIENTS: A SINGLE CENTER …
- Stomach-specific c-Myc overexpression drives gastric adenoma in mice through AKT/mammalian target of Rapamycin signaling
- Protein blend and casein supplementations before inactive phase similarly activate mechanistic target of Rapamycin signaling in rat skeletal muscle
- Gene expression and regulatory factors of the mechanistic target of Rapamycin (mTOR) complex 1 predict mammalian longevity
- Effectiveness of low dose of Rapamycin in preventing seizure-induced anxiety-like behaviour, cognitive impairment, and defects in neurogenesis in developing rats
- Regulatory effect of apoptosis on morphological changes in cell mass of porcine blastocyst through supplementation of Rapamycin during in vitro culture
- Identification of 3′, 4′, 5′-trihydroxyflavone as an mammalian target of Rapamycin inhibitor and its suppressive effects on dextran sulfate sodium-induced ulcerative …
- Living Donor Preemptive Kidney Transplantation in Tuberous Sclerosis Complex Patient and the Role of Mammalian Target of Rapamycin Inhibitor: A Case Report
- Rapamycin and Rapalogs
- miR-331-3p is involved in glucocorticoid resistance reversion by Rapamycin through suppression of the MAPK signaling pathway
- Suppression of Allograft Fibrosis by Regulation of Mammalian Target of Rapamycin-Related Protein Expression in Kidney-Transplanted Recipients Treated …
- Recent advances in the role of mammalian target of Rapamycin inhibitors on cardiac allograft vasculopathy
- Activation of Mechanistic Target of Rapamycin (mTOR) in Human Endothelial Cells Infected with Pathogenic Spotted Fever Group Rickettsiae
- Identification of a Novel Oxadiazole Inhibitor of Mammalian Target of Rapamycin
- An inducible system for in vitro and in vivo Fas activation using FKBP-FRB-Rapamycin complex
- Rapamycin attenuates gene expression of programmed cell death protein-ligand 1 and Foxp3 in the brain; a novel mechanism proposed for immunotherapy …
- Prediction of Solanum lycopersicum Target of Rapamycin (SlTOR) Protein
- Effect of In Vivo Expansion of Regulatory T Cells with IL-2/anti-IL-2 Antibody Complex Plus Rapamycin on Experimental Autoimmune Uveoretinitis
- Therapy options after CDK4/6 inhibitors for HR+, HER2-postmenopausal metastatic/recurrent breast cancer in Japan: a role for mammalian target of Rapamycin …
- Combination of Rapamycin and MK-2206 induced cell death via autophagy and necroptosis in MYCN-amplified neuroblastoma cell lines
- Refractory systemic juvenile idiopathic arthritis successfully treated with Rapamycin
- … Squamous Cell Carcinoma Growth Through Inactivation of Phosphoinositide 3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) and ERK …
- Long-term stability of 0.1% Rapamycin hydrophilic gel in the treatment of facial angiofibromas
- Rapamycin-induced autophagy plays a pro-survival role by enhancing up-regulation of intracellular ferritin expression in acute lymphoblastic leukemia
- Gambogic acid affects ribosomal occurrence in glioma cells by downregulating the phosphoinositide kinase-3/protein kinase b/mammalian target of Rapamycin …
- … Conductance Ca2+-Activated K+ Channels in C2C12 Skeletal Muscle Cells Increases the Myotube Diameter via the Akt/Mammalian Target of Rapamycin Pathway
- Pharmacokinetics of long-term low-dose oral Rapamycin in four healthy middle-aged companion dogs
- Rapamycin Re-Directs Lysosome Network, Stimulates ER-Remodeling, Involving Membrane CD317 and Affecting Exocytosis, in Campylobacter Jejuni-Lysate …
- The Mammalian Target of Rapamycin Complex 1 (mTORC1): An Ally of M. tuberculosis in Host Cells
- … promotes gallbladder cancer proliferation and metastasis through activating phosphatidylinositol 3-kinase/protein kinase B/mammalian target of Rapamycin …
- The long-term effects of Rapamycin-based immunosuppressive protocols on the expression of renal aquaporins 1, 2, 3 and 4 water channels in rats
- Efficient Treatment of Atherosclerosis by Dexamethasone Acetate and Rapamycin Co-Loaded mPEG-DSPE Calcium Phosphate Nanoparticles
- Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947
- Amino acids regulate energy utilization through mammalian target of Rapamycin complex 1 and adenosine monophosphate activated protein kinase pathway …
- Mammalian target of Rapamycin is activated in the kidneys of patients with scleroderma renal crisis
- Abstract B08: Improved tumor penetration, antitumor activity, and survival of ABI-009 (nab-sirolimus) versus oral Rapamycin and everolimus and investigation of mTOR …
- High-dose Rapamycin excerts a temporary impact on T. reesei through gene trFKBP12
- Effective and safe treatment of a novel IL2RA deficiency with Rapamycin
- DNA methylation age analysis of Rapamycin in common marmosets
- The use of Rapamycin to treat vascular tumours and malformations: A single-centre experience
- Treatment of angiokeratomas of Fordyce with topical Rapamycin 0.25% cream
- SUBCUTANEOUS IMPLANTATION OF Rapamycin IMPREGNATED SCAFFOLDS DEMONSTRATE THE POTENTIAL FOR LOCALISED ISLET GRAFT …
- GENERATION OF STABLE HUMAN INDUCED REGULATORY T-CELLS REQUIRES OPTIMAL Rapamycin CONCENTRATION AND TCR STIMULATION
- Effect of Calcineurin Inhibitors and Mammalian Target of Rapamycin Inhibitors on the Course of COVID-19 in Kidney Transplant Recipients
- The Effects of Evening Primrose/Hemp Seed Oil Compared to Rapamycin on the Gene Expression of Immunological Parameters in Experimental Autoimmune …
- Inhibitor for protein disulfide‑isomerase family A member 3 enhances the antiproliferative effect of inhibitor for mechanistic target of Rapamycin in liver cancer: An in …
- Corrigendum to: Differential Effects of Rapamycin and Metformin in Combination With Rapamycin on Mechanisms of Proteostasis in Cultured Skeletal Myotubes
- Treatment of port wine stain with Tixel‐induced Rapamycin delivery following pulsed dye laser application
- Effects and potential mechanisms of Rapamycin on MPTP-induced acute Parkinson’s disease in mice.
- In silico-based approach to investigate the ability of PEGylated Rapamycin to inhibit Galectin-3.
- Metabolic control of lupus pathogenesis: central role for activation of the mechanistic target of Rapamycin
- Can mammalian target of Rapamycin inhibitors replace mycophenolate in hypersensitized kidney transplant recipients?
- Primary cutaneous peripheral T-cell lymphoma, not otherwise specified with mammalian target of Rapamycin mutation: A novel finding for targeted treatment
- Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, Rapamycin
- Gene Expression Regulation in the Mouse Liver by Mechanistic Target Of Rapamycin Complexes I and II
- Effects of Glycerol and Shikimic Acid on Rapamycin Production in Streptomyces Rapamycinicus
- … and Platelet-derived Growth Factor-stimulated Vascular Smooth Muscle Cell Proliferation via Inhibiting the Mammalian Target of Rapamycin/p70 S6 Kinase …
- Spermidine and Rapamycin Reveal Distinct Autophagy Flux Response and Cargo Receptor Clearance Profile. Cells 2021, 10, 95
- Anti-scarring effect of Rapamycin following filtering surgery in rabbit eyes
- Correction for: Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
- Rapamycin PREVENTS INTERSTITIAL FIBROSIS THROUGH DECREASING PERITUBULAR CAPILLARY (PTC) VEGF EXPRESSION AND ANGIOGENESIS WHILE …
- Characteristics of Rapamycin-treated T cell products for advanced adoptive T cell therapy and evaluation of clinical feasibility
- Effects of Different Exercise Modes and Intensities on Skeletal Muscle Mammalian Target of Rapamycin Signaling in Strepto-zotocin and High-Fat-Diet Induced …
- Correction: Therapeutic effects of Rapamycin and surgical decompression in a rabbit spinal cord injury model
- Mammalian target of Rapamycin complexes: regulation and Alzheimer’s
- Modulation of the Antidepressant Effects of Ketamine by the mTORC1 Inhibitor Rapamycin
- Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic Rapamycin
- Subcutaneous nanotherapy repurposes the immunosuppressive mechanism of Rapamycin to enhance allogeneic islet graft viability
- The effect of Rapamycin on secretory activity of the rabbit ovarian fragments
- Microspheres scar formation glaucoma filtration surgery area therapeutic effect—Based on Rapamycin-chitosan-calcium alginate sustained-release
- Prenatal treatment with Rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model
- Full Activation of Kinase Protein Kinase B by Phosphoinositide-Dependent Protein Kinase-1 and Mammalian Target of Rapamycin Complex 2 Is Required for …
- Effect of Rapamycin on Canine Mast Cell Cancer Cells Following Radiation
- Rapamycin-eluting Single and Double Stenting on Serum Markers in Coronary Bifurcation Lesions
- Rapamycin Improves Recognition Memory and Normalizes Amino-Acids and Amines Levels in the Hippocampal Dentate Gyrus in Adult Rats Exposed to Ethanol …
- The independent and combined effects of Rapamycin and metformin on naturally occurring osteoarthritis
- … de la Lesión Hepática Inducida por Tioacetamida en ratas tratadas con Resveratrol: Rol de la vía de Señalización mTOR (mammalian Target of Rapamycin)
- Autism spectrum disorder and mammalian target of Rapamycin system
- Curcumin Promotes Recovery of Motor Function After Spinal Cord Injury in Rats Through Mammalian Target of Rapamycin (mTOR)-Signal Transducer and Activator of …
- Study on the Treatment of Tuberous Sclerosis with Rapamycin Nanomicelles Based on Abdominal Ultrasound.
- … Apoptosis of Gastric Cancer Cells via Phosphatidylinositol-3-Kinase (PI3K)/Protein Kinase B (Akt)/The Mammalian Target of Rapamycin (mTOR) Signaling Pathway
- Mammalian Target of Rapamycin (mTOR) Inhibitors Induce Stomatitis in Patients with Metastatic Breast Cancer
- Effect of adsorbing resins on the Rapamycin biosynthesis by Streptomyces hygroscopicus VKM Ac-2737D
- The Effect of Forkhead Box Class O1, Mammalian Target of Rapamycin Complex 1, Survivin, and Interleukin-17 on the Degree of Acne Vulgaris Based on Serum …
- Rapamycin as a potent and selective inhibitor of vascular endothelial growth factor receptor in breast carcinoma
- Pharmacological treatment of Autoimmune Polyendocrine Syndrome type I with Rapamycin, a mTOR inhibitor
- The role of salt inducible kinases in the regulation of the mammalian target of Rapamycin pathway in adipocytes
- Rapamycin repairs damaged nerve cells and neurological function in rats with spinal cord injury through ERK signaling pathway.
- Influence of an Early Application of Mammalian Target of Rapamycin Inhibitors Everolimus and Sirolimus on Acute Vascular Inflammatory Responses After Ischemia …
- miR-34 Promotes Autophagy and Apoptosis of Spinal Chondrocytes by Mammalian Target of Rapamycin/Phosphatidylinositol-3-Kinase/Protein Kinase B Signaling
- [Corrigendum] Rapamycin-induced autophagy activity promotes bone fracture healing in rats
- The Interactions Between the Mechanistic Target of Rapamycin (mTOR) and the Microbiome
- Sirtuins in mechanistic target of Rapamycin complex 1 signaling
- Rapamycin-PLGA microspheres induce autophagy and prevent senescence in chondrocytes and exhibit long in vivo residence
- Rapamycin alleviates experimental autoimmune hepatitis by immunoregulation of Th1 and Th17 cells
- Apoptosis Activation in Thyroid Cancer Cells by Jatrorrhizine-Platinum (II) Complex via Downregulation of PI3K/AKT/Mammalian Target of Rapamycin (mTOR) …
- Polyisoprenoids from Avicennia marina induces on P13k, Akt1, Mammalian target of Rapamycin, Egfr, and P53 Gene Expression Using Reverse Transcription …
- Rapamycin proves both good and bad for aging in human cells
- Repurposing metformin and Rapamycin to target age-related diseases
- The new target of Rapamycin: lysosomal calcium channel TRPML1
- THE EFFECT OF ENDURANCE TRAINING ON PROTEIN KINASE-B AND MECHANICAL TARGET OF Rapamycin IN THE LEFT VENTRICLE OF THE HEART OF …
- inhibition of mammalian target of Rapamycin (mTOR) improves neurobehavioral deficit and modulates inflammatory response after traumatic brain injury
- Targeting oxidative stress, transforming growth factor beta-1, and the mammalian target of Rapamycin by valproic acid to ameliorate bleomycin-induced …
- … Inhibits Proliferation and Promotes Apoptosis of Ovarian Cancer Cells by Inactivating Phosphoinositide-3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin …
- Is Rapamycin an Effective Anti-aging Drug?
- inhibition of the Mammalian Target of Rapamycin Pathway Stimulates Osteoblast Proliferation and Differentiation Through Autophagy in MC3T3-E1 Cells
- Abstract WP151: Rapamycin Improves Post-Recanalization Blood Flow After Acute Experimental Stroke in Rats
- Combination Therapy with Rapamycin and Imatinib in Pulmonary Arterial Hypertension
- The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A …
- Evaluation of the Effects of Rapamycin Treatment on Antioxidant Enzyme Changes and AgNOR in Testicular Torsion
- … Spinal Cord Repair and Nerve Regeneration Through Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling and Oxidative …
- Effect of Rapamycin combined with nedaplatin in the treatment of bladder cancer and its influence on angiogenesis and invasion
- Effect of glucose, soya oil and glutamine on protein expression and mammalian target of Rapamycin complex 1 pathway of jejunal crypt enterocytes in weaned piglets
- The Effect of Rapamycin and Metformin Treatment on Primary OA Pathology
- Mammalian target of Rapamycin complexes: protein synthesis and autophagy, Parkinson’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia
- The effect of mTOR inhibitor Rapamycin on a dietary Drosophila melanogaster model of calcium oxalate nephrolithiasis
- Abstract A28: Rapamycin-upregulated miR-29b promotes mTORC1-hyperactivative cell growth by downregulating retinoic acid receptor β (RARβ)
- Mammalian target of Rapamycin inhibitors after post-transplant hepatocellular carcinoma recurrence: Is it too late?
- Interleukin-27 decreases ghrelin production through signal transducer and activator of transcription 3—mechanistic target of Rapamycin signaling
- Combined application of Rapamycin and atorvastatin improves lipid metabolism in apolipoprotein E-deficient mice with chronic kidney disease.
- Effect of mammalian target of Rapamycin on cognitive dysfunction of Alzheimer’s Disease via regulating Homer3
- Impact of Rapamycin on Secondary Infection of Laboratory Mice (Mus musculus) with the Intestinal Nematode Heligmosomoides bakeri
- Evaluation of TGF-beta, Rapamycin, and IL-2 microparticle (TRI MP) treatment for disease prevention in models of type 1 diabetes and arthritis
- Cell Synchronization by Rapamycin Improves the Developmental Competence of Buffalos (Bubalus bubalis) SCNT Embryos.
- Corrigendum to” Rapamycin Reverses TLR4 Signaling-Triggered Tumor Apoptosis Resistance by Disrupting Akt-mediated Bcl-xL Upregulation”[Int …
- publisher correction: Regulation of protein kinase cδ nuclear import and Apoptosis by Mechanistic Target of Rapamycin Complex-1
- … the Proliferation of Human Ovarian Cancer Cells In Vitro via the Phosphatidylinositol-3-Kinase (PI3K)/Akt and the Mammalian Target of Rapamycin (mTOR) and Wnt/β …
- Correction: Rapamycin increases CCN2 expression of lung fibroblasts via phosphoinositide 3-kinase
- Rapamycin prevents the impairments of social recognition induced by anti-P antibody in a murine model
- Supporting Data for” Identification of Novel Components of Target-of-Rapamycin Signaling Pathway by Network-Based Multi-Omics Integrative Analysis”
- Rapamycin eluting stent implantation in the treatment of total coronary artery occlusion in a case of Kawasaki disease
- Investigation of the Effects of mTOR Inhibitors Rapamycin and Everolimus in Combination with Carboplatin on Canine Malignant Melanoma Cells.
- Rapamycin alleviates the symptoms of experimental autoimmune myasthenia gravis rats by down-regulating Th17 cell/regulatory T cell ratio
- 235 Effects of Rapamycin during an acute heat stress exposure in growing pigs
- Rapamycin and Rapalogs for Tuberous Sclerosis Complex: Updates on Studies’ and Outcomes’ Characteristics of a Cochrane Systematic Review
- … : Activation of autophagic flux against xenoestrogen bisphenol-A-Induced hippocampal neurodegeneration via AMP kinase (AMPK)/mammalian target of Rapamycin …
- inhibition of mammalian target of Rapamycin (mTOR) improves neurobehavioral deficit and modulates inflammatory response after traumatic brain injury
- Combination Therapy of Sildenafil and Rapamycin Alleviates Doxorubicin Induced Cardiotoxicity With Improvement of Skeletal Muscle Function
- Rapamycin ON THE TREATMENT OF MUCOEPIDERMOID CARCINOMAS AND SQUAMOUS CELL CARCINOMAS
- Amino Acid Sensing Ability by the Mechanistic Target of Rapamycin in Oligodendrocytes
- Rescue of Lipid-Induced Autophagy inhibition by Rapamycin Treatment
- Rapamycin‐Dependent Gln3 Transcription Factor Dephosphorylation and Nuclear Localization Depend On Distinct Regions of the Gln3 Protein
- Evaluation of S100A9 targeted nanoparticles containing Rapamycin to treat pancreatic adenocarcinoma
- … Cells In Vitro and in Mouse Tumor Xenografts and Activates Autophagy and Apoptosis by Downregulation of the Mammalian Target of Rapamycin (mTOR)/PI3K/AKT …
- … Shenzhu Tiaopi granule on hepatic insulin resistance in diabetic Goto-Kakizakirats via liver kinase B1/adenosine 5′-monophosphate/mammalian target of Rapamycin …
- Retracted: inhibition of Nasopharyngeal Carcinoma by Beta-Lapachone Occurs by Targeting the Mammalian Target of Rapamycin (mTOR)/PI3K/AKT Pathway …
- Correction: Alternative mammalian target of Rapamycin (mTOR) signal activation in sorafenib-resistant hepatocellular carcinoma cells revealed by array-based …
- Mechanistic Target of Rapamycin, but Not the Integrated Stress Response, Promotes ATF4-Dependent Metabolic Reprogramming in TGF-β-Treated Lung Fibroblasts
- … Protein of Mammalian Target or Rapamycin mRNA (RPTOR) and Rapamycin‐insensitive Companion of Mammalian Target of Rapamycin (RICTR) messenger RNA
- Rapamycin inhibits colorectal cancer progression through down-regulating mTOR-GP73 pathway
- Abstract PS14-17: Rapamycin inhibits stem cell function and diminishes inflammation and senescence markers in human mammary gland
- Intermittent Fasting (IF) Promotes Longevity through Alterations of the Mammalian Target of Rapamycin (mTOR) and the Epigenome
- Rapamycin-based GVHD prophylaxis increases the immunosuppressivity of MDSCs without affecting T cells and anti-tumor cytotoxicity.
- Effects of Quercetin on Autophagy and Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway in Human Prostate Cancer …
- The effect of high intensity interval training on complex mammalian target of Rapamycin 1 (mTORC1) pathway in Flexor hallucis longus muscle (FHL) of …
- Six-year angiographic follow-up of a chronic total coronary occlusion successfully treated with BMS implantation followed by oral Rapamycin
- Maf1 suppression of ATF5-dependent mitochondrial unfolded protein response contributes to Rapamycin-induced radio-sensitivity in lung cancer cell line A549.
- COMPARISON OF Rapamycin WITH CYCLOSPORIN, AND TACROLIMUS IN REGARDS TO THE DEVELOPMENT OF EPITHELIAL-TO-MESENCHYMAL …
- Abstract PS16-18: inhibition of mTOR signaling by Rapamycin abrogates mammary stem/progenitor cell activity in aged mice
- Rapamycin does not reproduce the alterations to Caco‐2 transepithelial electrical resistance caused by the knockdown of Raptor
- Oral preconditioning of donors after brain death with calcineurin inhibitors vs. inhibitors of mammalian target for Rapamycin in pig kidney transplantation
- Rapamycin immune tolerization enables gene transfer following subcutaneous delivery of AAV6 but not CD4-retargeted AAV6 vectors in AAV-seropositive …
- mTOR Inhibitor Rapamycin can reverses the combination antiretroviral therapy induced central nervous system disorder
- Corrigendum to” Rapamycin suppresses TLR4-triggered IL-6 and PGE 2 production of colon cancer cells by inhibiting TLR4 expression and NF-κB activation”[Mol …
- Rapamycin and chloroquine insensitivity reveal mTORC1‐independent regulation of epithelial permeability in differentiated intestinal Caco‐2 cells
- … -4-one (PP-4-one) Exhibits Anti-Epileptogenic Effect in Rat Model of Traumatic Epilepsy by Mammalian Target of Rapamycin (mTOR) Signaling Pathway …
- Mammalian Target of Rapamycin Mediates Expression and Activity of ADAM 17 in Diabetic Kidney Disease
- Gattino, F; Biolatti, B; Sasaki, N; Nakagawa, T; Di Renzo, Mf; de Las Mulas, Jm; De Maria, R.. Activation of mammalian target of Rapamycin (mTOR) in triple …
- Gorham-Stout disease successfully treated with sirolimus (Rapamycin): a case report and review of the literature
- Age-dependent effects of short-term intermittent fasting and Rapamycin treatment in Zebrafish (Danio Rerio) brain
- Molecular Dynamic Simulations for Mammalian Target of Rapamycin (mTOR) Variants to Characterize Potential Disruption of Porphyromonas gingivalis Induced …
- Defining the properties of the OS-33 osteosarcoma cell line and the effects of mTORC1 inhibition by Rapamycin treatment
- Deletion of the mechanistic‐target‐of‐Rapamycin (mTOR) from collecting duct principal associated with increased ubiquitinylation of epithelial sodium channel (ENaC)
- Construction of lentiviral vector for late endosomal/lysosomal adaptor, mitogen-activated protein kinase and mammalian target of Rapamycin activator 2 interference …
- 85 Regulation of mammalian target of Rapamycin signaling post-fertilisation is essential for efficient development of bovine pre-implantation embryos
- … SUPPRESSES SQUAMOUS DIFFERENTIATION OF BLADDER CANCER AND CANCER GROWTH VIA REGULATION OF MAMMALIAN TARGET OF Rapamycin …
- Abstract A16: Suppressor of morphogenesis in genitalia 1 (SMG1) is a novel negative regulator of mammalian target of Rapamycin complex 2 (mTORC2)
- … by Chemokine (CC Motif) Ligand 3 Promote the Progression of Breast Cancer via Phosphoinositide 3-Kinase-Protein Kinase B-Mammalian Target of Rapamycin …
- … Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin …
- 69 Phosphorylation of mechanistic target of Rapamycin in porcine blastocyst-stage embryos is dependent on the concentration of glutamine in the medium
