COLD SHOCK PROTEINS
February 21, 2022NOREPINEPHRINE
February 21, 2022
- Hematopoietic Stem cell exhaustion impacted by p18INK4C and p21Cip1/Waf1 in opposite manners
- mTOR mediates Wnt-induced epidermal Stem cell exhaustion and aging
- Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis
- The Polycomb group gene Ezh2 prevents hematopoietic Stem cell exhaustion
- Relationships between Stem cell exhaustion , tumour suppression and ageing
- Stem cell exhaustion and leukemogenesis
- Progeria of Stem cells: Stem cell exhaustion in Hutchinson-Gilford progeria syndrome
- Short telomeres and Stem cell exhaustion model Duchenne muscular dystrophy in mdx/mTR mice
- Genetic regulation of hematopoietic Stem cell exhaustion during development and growth
- Could metabolic syndrome, lipodystrophy, and aging be mesenchymal Stem cell exhaustion syndromes?
- … ‐up of recipients of allogeneic bone marrow grafts reveals no progressive telomere shortening and provides no evidence for haematopoietic Stem cell exhaustion
- Pre-CFU-S quiescence and Stem cell exhaustion after cytostatic drug treatment: protective effects of the inhibitory peptide pGlu-Glu-Asp-Cys-Lys (pEEDCK)
- … be the intracellular determinants of longevity implicated in the progeric influence of obesity: Insulin, IGF-1, and leptin may all conspire to promote Stem cell exhaustion
- Stem cell exhaustion and atherosclerosis
- Hematopoietic Stem cell Quiescence Maintained by p21cip1/waf1
- Stem cell aging: what bleach can teach
- Growth signaling at the nexus of Stem cell life and death
- p21 loss compromises the relative quiescence of forebrain Stem cell proliferation leading to exhaustion of their proliferation capacity
- Stem cells and the rate of living
- DNA repair is limiting for haematopoietic Stem cells during ageing
- A Limited Role for p21Cip1/Waf1 in Maintaining Normal Hematopoietic Stem cell Functioning
- Deconstructing Stem cell self-renewal: genetic insights into cell -cycle regulation
- Does Stem cell exhaustion result from combining hematopoietic
- Signaling circuitries controlling Stem cell fate: to be or not to be
- Epigenetic control of hematopoietic Stem cell aging the case of Ezh2
- Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis
- The p53 tumor suppressor protein is a critical regulator of hematopoietic Stem cell behavior
- Loss of Foxo3a In FA Mice Leads to Hematopoietic Stem cell exhaustion That Can Be Attenuated by Natural Anti-Oxidant Quercetin.
- Understanding the Impact of Inflammation on Hematopoietic Stem Cells.
- Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and Stem cell loss
- Accumulation of DNA damage in hematopoietic Stem and progenitor cells during human aging
- Cellular aging leads to functional heterogeneity of hematopoietic Stem cells: a modeling perspective
- Balancing dormant and self-renewing hematopoietic Stem cells
- Telomere length dynamics in normal hematopoiesis and in disease states characterized by increased Stem cell turnover
- Controlling Stem cell proliferation: CKIs at work
- Cellular memory and hematopoietic Stem cell aging
- Enrichment of hematopoietic Stem cells with SLAM and LSK markers for the detection of hematopoietic Stem cell function in normal and Trp53 null mice
- Impaired hematopoietic Stem cell functioning after serial transplantation and during normal aging
- A dual role of p21 in Stem cell aging
- Mechanisms of Stem cell ageing
- Intrinsic and extrinsic control of haematopoietic Stem–cell self-renewal
- Runx family genes, niche, and Stem cell quiescence
- The haematopoietic Stem cell niche: new insights into the mechanisms regulating haematopoietic Stem cell behaviour
- Advances in hematopoietic Stem cell research through mouse genetics
- DNA repair is crucial for maintaining hematopoietic Stem cell function
- Regulation of hematopoietic Stem cell aging in vivo by a distinct genetic element
- Impaired Stem cell collection by consecutive courses of high-dose mobilizing chemotherapy using cyclophosphamide, etoposide, and G-CSF
- Peripheral Stem cell mobilization and engraftment in patients over age 60
- The chiaroscuro Stem cell : a unified Stem cell theory
- Quiescence regulators for hematopoietic Stem cell
- Hematopoietic Stem cell aging and self-renewal
- Etiology of limbal Stem cell transplantation failure
- DNA repair in Stem cell maintenance and conversion to cancer Stem cells
- Repopulating defect of mismatch repair–deficient hematopoietic Stem cells
- Genetic Uncoupling of the Regulation of Hematopoietic Stem cell Quiescence and Self-Renewal.
- MicroRNA miR-125a controls hematopoietic Stem cell number
- The nuclear receptor tailless induces long-term neural Stem cell expansion and brain tumor initiation
- Marrow aplasia developing 3 years after treatment with busulphan for chronic myeloid leukaemia
- Loss of proliferative capacity in immunohemopoietic Stem cells caused by serial transplantation rather than aging.
- Breaking the cell cycle of HSCs by p57 and friends
- G-CSF in the long-term treatment of cyclic neutropenia and chronic idiopathic neutropenia in adult patients.
- Mechanisms of hematopoietic Stem cell aging
- Failure of ocular surface reconstruction with amniotic membrane transplantation and living-related conjunctival limbal allograft
- Mechanisms that mediate Stem cell self‐renewal and differentiation
- Meeting summary: International Symposium and Workshop on Hematopoietic Stem Cells VI, University of Tübingen, Germany, September 14–16, 2006
- Live and let die: in vivo selection of gene-modified hematopoietic Stem cells via MGMT-mediated chemoprotection
- Clonal escape in Fanconi anemia: new hurdle for gene therapy?
- Aging of Hematopoietic Stem Cells LM Kamminga, R. van Os, A. Ausema, B. Dontje, G. DE HAAN
- Stem cell GENETICS AND GENOMICS: CONCISE REVIEW
- Identification of additional genetic alterations in RUNX1 related leukemias
- Simultaneous Maintenance of Human Cord Blood SCID‐Repopulating Cells and Expansion of Committed Progenitors at Low O2 Concentration (3%)
- How Stem cells age and why this makes us grow old
- Minimal residual disease and discontinuation of therapy in chronic myeloid leukemia: can we aim at a cure?
- Delayed mammary gland development in the p53+/m mouse, a model of accelerated aging
- Long-term interleukin-3 and intensive immunosuppression in the treatment of aplastic anemia.
- cell cycle entry of hematopoietic Stem and progenitor cells controlled by distinct cyclin-dependent kinase inhibitors
- The elements of Stem cell self-renewal: a genetic perspective
- Adult Stem cell maintenance and tissue regeneration in the ageing context: the role for A‐type lamins as intrinsic modulators of ageing in adult Stem cells and their …
- Iron overload and haematopoiesis in MDS: does blood transfusion promote progression to AML?
- Metabolic rate determines haematopoietic Stem cell self-renewal
- Vascular aging: insights from studies on cellular senescence, Stem cell aging, and progeroid syndromes
- Pivotal role for glycogen synthase kinase–3 in hematopoietic Stem cell homeostasis in mice
- Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic Stem cells
- Hematopoietic Support by Endothelium
- Maintenance of quiescent hematopoietic Stem cells in the osteoblastic niche
- Germline Stem Cells: The First Guards of Heredity
- Cancer Stem cells and “Stemness” genes in neuro-oncology
- Granulocyte colony stimulating factor for bone marrow transplantation
- Deciphering the signaling pathways of cancer Stem cells of glioblastoma multiforme: role of Akt/mTOR and MAPK pathways.
- Aplastic anaemia: considerations on the pathogenesis
- A human iPSC model of Hutchinson Gilford Progeria reveals vascular smooth muscle and mesenchymal Stem cell defects
- Age-Adjusted Telomere Length Is Not Associated with Variation in Hematological Parameters in Ageing Women
- Ewing sarcoma gene Ews regulates hematopoietic Stem cell senescence
- Notch signaling is required to maintain all neural Stem cell populations–irrespective of spatial or temporal niche
- A conundrum in mammalian hematopoietic Stem cell polarity
- CAMT: new findings and new questions
- cell cycle regulators in Stem cells
- Musashi1: a Stem cell marker no longer in search of a function
- The CDK inhibitors: potential targets for therapeutic Stem cell manipulations?
- Therapeutic targeting of a Stem cell niche
- Lessons learned from the study of JunB: new insights for normal and leukemia Stem cell biology
- The MicroRNA pathway plays a regulatory role in Stem cell division
- Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic Stem cell development
- HOXB4 overexpression mediates very rapid Stem cell regeneration and competitive hematopoietic repopulation
- p53 regulates hematopoietic Stem cell quiescence
- Regulation of hematopoietic Stem cells by the steel factor/KIT signaling pathway
- Hematopoietic Stem cells and the genetics of aging
- Stem cells and aging in the hematopoietic syStem
- Wnt signaling in the niche enforces hematopoietic Stem cell quiescence and is necessary to preserve self-renewal in vivo
- The role of the chromatin remodeler Mi-2β in hematopoietic Stem cell self-renewal and multilineage differentiation
- Adult Stem cell therapy beyond haemopoietic Stem cell transplantation? An update
- Calmodulin-dependent Protein Kinase IV Regulates Hematopoietic Stem cell Maintenance*♦
- mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to Stem cell renewal and …
- Cdc42: a signal coordinator in hematopoietic Stem cell maintenance
- Thioredoxin-interacting protein regulates hematopoietic Stem cell quiescence and mobilization under stress conditions
- Epigenetic regulation of Stem cells in cancer and aging
- IL‐3 and peripheral blood Stem cell harvesting
- Stem cell ageing: does it happen and can we intervene?
- Stem cell factor enhances dendritic cell development
- Effect of Stem cell factor (c-kit ligand), granulocyte-macrophage colony stimulating factor and interleukin 3 on hematopoietic progenitors in human long-term bone …
- Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic Stem cell property
- Stem–cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
- Stem cell injury and premature senescence
- Haemopoietic Stem cell inhibition: Potential for dose intensification
- JunB protects against myeloid malignancies by limiting hematopoietic Stem cell proliferation and differentiation without affecting self-renewal
- Genistein induces radioprotection by hematopoietic Stem cell quiescence
- Peripheral Stem cell mobilization and engraftment in patients over age 60
- PTEN negatively regulates neural Stem cell self-renewal by modulating G0-G1 cell cycle entry
- Ionizing radiation and aging: rejuvenating an old idea
- The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other Stem/progenitor cell populations
- Effects of prior therapy on the in vitro proliferative potential of Stem cell factor plus filgrastim-mobilized CD34-positive progenitor cells.
- DNA repair defects in Stem cell function and aging
- DNA damage response in adult Stem cells: pathways and consequences
- Telomere dysfunction induces environmental alterations limiting hematopoietic Stem cell function and engraftment
- Survival analysis of conjunctival limbal grafts and amniotic membrane transplantation in eyes with total limbal Stem cell deficiency
- Fanconi anemia Stem cells: going round and round
- Hematopoietic Stem cell self-renewal
- Polycomb group genes: keeping Stem cell activity in balance
- Cyclophosphamide, doxorubicin, vincristine, prednisone dose intensification with granulocyte colony-stimulating factor markedly depletes Stem cell reserve for …
- Dedifferentiation rescues senescence of progeria cells but only while pluripotent
- Notch signaling in the regulation of Stem cell self-renewal and differentiation
- Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition
- Decline in self-renewal factors contributes to aging of the Stem cell niche in the Drosophila testis
- YY1 PcG function as a potential cancer therapeutic target
- Stem cell proliferation and quiescence—two sides of the same coin
- Awakening dormant haematopoietic Stem cells
- c-Myc controls the balance between hematopoietic Stem cell self-renewal and differentiation
- Multi-genetic events collaboratively contribute to Pten-null leukaemia Stem–cell formation
- Regulation of bone marrow-derived vascular progenitor cell mobilization and maintenance
- Latent hematopoietic Stem cell toxicity associated with protracted drug administration
- Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic Stem cells
- Hematopoietic Stem cell development, aging and functional failure
- Bone marrow-derived cells: the influence of aging and cellular senescence
- Effects of dietary restriction on hematopoietic Stem–cell aging are genetically regulated
- p16INK4a and Stem cell Ageing: A Telomere-Independent Process?
- FILAMENTARY KERATITIS-A REVIEW OF ETIOP A REVIEW OF ETIOPATHOGENESIS AND MANAGEMENT THOGENESIS AND MANAGEMENT
- Limiting factors in murine hematopoietic Stem cell assays
- Pbx1 regulates self-renewal of long-term hematopoietic Stem cells by maintaining their quiescence
- Telomere dysfunction and Stem cell ageing
- The daunting task of modeling response to imatinib therapy in patients with chronic myelogenous leukemia
- Telomeres and telomerase in cancer Stem cells
- Pten deletion in adult neural Stem/progenitor cells enhances constitutive neurogenesis
- Endothelial progenitor cell mobilization after percutaneous coronary intervention
- The transcription factor EGR1 controls both the proliferation and localization of hematopoietic Stem cells
- Tissue engineering of the cornea
- Intrinsic control of Stem cell fate
- Effects of Prior Therapy on the in Vitro Proliferative Potential of Stem cell Factor Plus Filgrastim-mobilized CD34-positive Progenitor Cells1
- Hematopoiesis: an evolving paradigm for Stem cell biology
- The pessimist’s and optimist’s views of adult neurogenesis
- Mechanisms controlling hematopoietic Stem cell functions during normal hematopoiesis and hematological malignancies
- Mouse Model: Telomeres and Telomerase in Stem cell and Cancer
- Stem cell model of hematopoiesis
- Goralatide (AcSDKP), a negative growth regulator, protects the Stem cell compartment during chemotherapy, enhancing the myelopoietic response to GM‐CSF
- A risk-benefit assessment of epoetin in the management of anaemia associated with cancer
- Compartmentalized organization: a common and required feature of Stem cell niches?
- Tuning mTORC1 activity for balanced self-renewal and differentiation
- Gene therapy approaches for Stem cell protection
- Loss of the Rho GTPase activating protein p190-B enhances hematopoietic Stem cell engraftment potential
- Hematopoietic Stem cells and aging
- HEMATOPOIETIC Stem cell TRANSFER: LBNT1 VIRUS VECTORS
- The stromal cells’ guide to the Stem cell universe
- Regulation of murine hematopoietic Stem cell quiescence by Dmtf1
- Signaling through BMPR-IA regulates quiescence and long-term activity of neural Stem cells in the adult hippocampus
- Tumor suppressor dosage regulates Stem cell dynamics during aging
- Mesenchymal Stem cell transplantation for tissue repair
- EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation
- Telomeres in hematopoietic Stem cells
- Regulation of Stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with …
- The roles of EZH2 in cell lineage commitment
- Hematopoietic Stem cell aging: wrinkles in Stem cell potential
- Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition
- Genomic instability in induced Stem cells
- Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
- Human skin Stem cells and the ageing process
- Polycomb repressive complex 2 is dispensable for maintenance of embryonic Stem cell pluripotency
- Ontogenic growth of the haemopoietic Stem cell pool in humans
- Inside Blood: a roadmap to the best and brightest
- A low level of reactive oxygen species selects for primitive hematopoietic Stem cells that may reside in the low-oxygenic niche
- Stem cells, DNA damage, ageing and cancer
- Hematopoietic Stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family
- Polycomb repressive complex 2 (PRC2) restricts hematopoietic Stem cell activity
- Maintenance of adult Stem cells: Role of the Stem cell niche
- The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic Stem cells
- Metabolic regulation of hematopoietic Stem cells in the hypoxic niche
- Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell -cycle arrest
- Ci er chun he duan li yu qing jiang yu Oryzias melastigma shou ming de xiang guan xing yan jiu
- Clonal diversity of the Stem cell compartment
- Rac1 is required for epithelial Stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice
- Manifestations and mechanisms of Stem cell aging
- 6 2 6 Editorials The Journal of Pediatrics November 1996
- Age-specific bone tumour incidence rates are governed
- Autologous limbal transplantation in unilateral chemical burns
- Tracking down the Stem cells of the intestine: strategies to identify adult Stem cells
- Gfi-1: another piece in the HSC puzzle
- Polycomb group proteins: multi-faceted regulators of somatic Stem cells and cancer
- Toward ‘SMART’Stem cells
- Expression of Stem cell markers on mononuclear cells derived from heparinized cadaveric organ donors before and after disconnection from the respirator
- Handbook on Immunosenescence: Basic Understanding and Clinical Applications
- Understanding cellular networks to improve hematopoietic Stem cell expansion cultures
- Regulation of Self-Renewing Divisions in Normal and Leukaemia Stem Cells
- Using naturally occurring tumours in dogs and cats to study telomerase and cancer Stem cell biology
- Impaired PBPC collection in patients with myeloma after high-dose melphalan
- Human Stem cell engraftment in sheep
- Transplantation of hematopoietic Stem cells from the peripheral blood
- The molecular specificity of action of the tetrapeptide acetyl‐n‐ser‐asp‐lys‐pro (AcSDKP) in the control of hematopoietic Stem cell proliferation
- Altered mammary gland development in the p53+/m mouse, a model of accelerated aging
- Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates
- Plzf regulates germline progenitor self-renewal by opposing mTORC1
- Telomere attrition occurs during ex vivo expansion of human dental pulp Stem cells
- Rapamycin and quasi-programmed aging: Four years later
- At the Stem of youth and health
- Heterozygous kit mutants with little or no apparent anemia exhibit large defects in overall hematopoietic Stem cell function
- Hematopoietic Stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
- cell cycle regulators in adult Stem cells
- Estimating dormant and active hematopoietic Stem cell kinetics through extensive modeling of bromodeoxyuridine label-retaining cell dynamics
- The p53–p66shc–manganese superoxide dismutase (MnSOD) network: a mitochondrial intrigue to generate reactive oxygen species
- Hemopoietic function after use of IL-1 with chemotherapy or irradiation
- A Stem cell fusion model of carcinogenesis.
- Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
- Regulation of murine hematopoietic Stem cell quiescence by cyclin D binding myb-like transcription factor-1, Dmtf1
- Signaling pathways in self-renewing hematopoietic and leukemic Stem cells: do all Stem cells need a niche?
- Bone marrow Stem cell protection from chemotherapy by low–molecular-weight compounds
- Unraveling the complex regulation of Stem cells: implications for aging and cancer
- CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration
- 2010 International Forum on Stem Cells (November 11–13; Tianjin, China)
- The autophagy protein Atg7 is essential for hematopoietic Stem cell maintenance
- p53-mediated hematopoietic Stem and progenitor cell competition
- Pharmacological inhibition of EGFR signaling enhances G-CSF–induced hematopoietic Stem cell mobilization
- Sustained activation of mTOR pathway in embryonic neural Stem cells leads to development of tuberous sclerosis complex-associated lesions
- Runx1 loss minimally impacts long-term hematopoietic Stem cells
- Sirolimus and tacrolimus binding proteins: double-edged swords for GVHD prophylaxis
- In vivo selection using a cell -growth switch
- Mesenchymal Stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth
- Telomeres and Telomerase
- Tracking adult Stem cells
- The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal Stem cell niche
- Identification of tumor-initiating cells in a p53-null mouse model of breast cancer
- Telomere biology in hematopoiesis and Stem cell transplantation
- Evaluation and eligibility of HLA‐identical sibling donors for Stem cell /bone marrow donation
- Ontogeny-related changes in proliferative potential of human hematopoietic cells.
- Establishment of an aging model of Sca-1+ hematopoietic Stem cell and studies on its relative biological mechanisms
- Modern genome-wide genetic approaches to reveal intrinsic properties of Stem cells
- Hematopoietic Stem cell Aging and Fate Decision
- Epithelial Stem cells: An epigenetic and wnt‐centric perspective
- Marked telomere fluctuation of leukocytes during graft-versus-host disease in allogeneic Stem cell transplantation
- Macrophage Inflammatory Protein-1α and Stem cell Inhibition
- Hematopoietic Stem cell Aging and Fate Decision
- Cytokine-mediated expansion does not deplete cord blood cells with Stem cell characteristics
- Ways of minimising hematopoietic damage induced by radiation and cytostatic drugs—the possible role of inhibitors
- Hematopoietic Stem cell emergence in embryonic life: developmental hematology revisited
- Cancer therapy-induced residual bone marrow injury: mechanisms of induction and implication for therapy
- Hayflick’s hypothesis: an approach to in vivo testing
- Expansion of LTC-ICs and Maintenance of p21 and BCL-2 Expression in Cord Blood CD34+/CD38− Early Progenitors Cultured over Human MSCs as a Feeder …
- Haemoprotection against cytostatic drugs by Stem cell inhibition
- All-trans retinoic acid induces proliferation of an irradiated Stem cell supporting stromal cell line AFT024
- Progress in the development of syStems for in vitro expansion of human hematopoietic Stem cells
- Homeostasis of telomere length rather than telomere shortening after allogeneic peripheral blood Stem cell transplantation
- From tissue turnover to the cell of origin for pancreatic cancer
- Hematopoietic Stem cells: generation and self-renewal
- Improved outcome following allogeneic Stem cell transplantation in chronic myeloid leukemia is associated with higher expression of BMI-1 and immune …
- Hematopoietic progenitor/Stem cells immortalized byLhx2 generate functional hematopoietic cells in vivo
- Hematopoiesis from human embryonic Stem cells
- Current concepts in the pathophysiology and treatment of aplastic anemia
- Do we have to kill the last CML cell ?
- High‐dose therapy with peripheral blood Stem cell transplantation results in a significant reduction of the haemopoietic progenitor cell compartment
- cell death by sugar: Bittersweet TOR
- Fanconi anaemia: new strategies
- Aplastic anemia: pathogenesis and treatment
- Epigenetic modifications of Stem cells: a paradigm for the control of cardiac progenitor cells
- Splenic primitive hematopoietic Stem cell (PHSC) activity is enhanced by steel factor because of PHSC proliferation
- Stem cell factor augments tumor necrosis factor-granulocyte-macrophage colony-stimulating factor-mediated dendritic cell hematopoiesis
- Rapamycin and other longevity‐promoting compounds enhance the generation of mouse induced pluripotent Stem cells
- The microRNA cluster miR-106b~ 25 regulates adult neural Stem/progenitor cell proliferation and neuronal differentiation
- Stems cells and the pathways to aging and cancer
- The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic Stem cells
- Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective …
- Polycomb silencers control cell fate, development and cancer
- In vivo radioprotective effect of AcSDKP on canine myelopoiesis
- Hypoxia-inducible factors and marrow stromal function
- Management of Acute Leukemia
- Polycomb group proteins in hematopoietic Stem cell aging and malignancies
- Transient mTOR inhibition facilitates continuous growth of liver tumors by modulating the maintenance of CD133+ cell populations
- Posttransplant hematopoiesis in patients undergoing sibling allogeneic Stem cell transplantation reflects that of their respective donors although with a lower functional …
- Hematopoietic Stem cells are not the direct target of spontaneous leukemic transformation in p18INK4C-null reconstituted mice
- Stonewalling Drosophila Stem cell differentiation by epigenetic controls
- Hematopoietic Stem cell expansion
- The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic Stem cells
- The critical role of agrin in the hematopoietic Stem cell niche
- Fancd2 −/− mice have hematopoietic defects that can be partially corrected by resveratrol
- cell cycle and developmental control of hematopoiesis by Runx1
- Genotoxic stress abrogates renewal of melanocyte Stem cells by triggering their differentiation
- Gone with the Wnt/Notch: Stem cells in laminopathies, progeria, and aging
- Differentiation of neural Stem cells into oligodendrocytes: involvement of the polycomb group protein Ezh2
- Melanocyte Stem cells
- Hematopoietic Stem cells and the aging hematopoietic syStem
- In vivo T-cell dynamics during immune reconstitution after hematopoietic Stem cell gene therapy in adenosine deaminase severe combined immune deficiency
- Hemopoietic Function After Use of IL-1 with
- Genetic Regulation of Hematopoietic Stem cell Aging
- Wnt Signaling in the Niche Enforces Hematopoietic Stem cell Quiescence and Is Necessary to Preserve Self-Renewal…
- Pathophysiologic mechanisms in acquired aplastic anemia
- EWS-FLI-1 expression triggers a Ewing’s sarcoma initiation program in primary human mesenchymal Stem cells
- Shifting senescence into quiescence by turning up p53
- The Wnt receptor, Lrp5, is expressed by mouse mammary Stem cells and is required to maintain the basal lineage
- Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic Stem cells
- Clonal haemopoiesis may occur after conventional chemotherapy and is associated with accelerated telomere shortening and defects in the NQO1 pathway; possible …
- Cellular and Molecular Crossroads of Cancer and Aging
- Chaotic dynamic stabilities and instabilities of hematopoietic Stem cell growth plasticity
- Have We Reached the Point for In Vivo Rejuvenation?
- Developmental plasticity of Stem cells and diseases
- Musashi1 modulates mammary progenitor cell expansion through proliferin-mediated activation of the Wnt and Notch pathways
- Impact papers on aging in 2009
- Principles of hematopoietic Stem cell biology
- The t (6; 9) associated DEK/CAN fusion protein targets a population of long-term repopulating hematopoietic Stem cells for leukemogenic transformation
- GATA2 finds its macrophage niche
- Donor age and cell passage affects differentiation potential of murine bone marrow-derived Stem cells
- Hematopoietic Stem cells
- Reduced Proliferative Capacity of Hematopoietic Stem Cells Deficient in Hoxb3 and Hoxb4
- Roles of PPAR and p21WAF1/CIP1 in monocyte/macrophage differentiation: are circulating monocytes able to proliferate?
- The aryl hydrocarbon receptor: regulation of hematopoiesis and involvement in the progression of blood diseases
- Bigger is better: maternal and neonatal predictors of hematopoietic potential of umbilical cord blood units
- Transcription factor Gfi1 regulates self‐renewal and engraftment of hematopoietic Stem cells
- Wnt/β-catenin signaling induces the aging of mesenchymal Stem cells through the DNA damage response and the p53/p21 pathway
- cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity
- Preservation of Hemopoietic Stem Cells
- Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression
- 10 Epigenetics in Cancer Stem cell Development
- The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
- Blood disorders in the elderly
- Normal Stem cells and cancer Stem cells: similar and different
- Attributes of adult Stem cells
- Risk-adapted procedures for HSCT from alternative donor in children with severe aplastic anaemia
- Stem cell niches and other factors that influence the sensitivity of bone marrow to radiation-induced bone cancer and leukaemia in children and adults
- E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors
- Haploinsufficiency of SNEV causes defects of hematopoietic Stem cells functions
- The Future of Hematopoietic Growth Factors
- Telomere length in paroxysmal nocturnal hemoglobinuria correlates with clone size
- Genetic marking as an approach to studying in vivo hematopoiesis: progress in the non-human primate model
- Standardization of hematopoietic Stem cell assays: a summary of a workshop and working group meeting sponsored by the National Heart, Lung, and Blood Institute …
- Identification of Stem cell transcriptional programs normally expressed in embryonic and neural Stem cells in alloreactive CD8+ T cells mediating graft-versus …
- Inhibitors of haemopoiesis and their potential clinical relevance
- Aging Stem cells, latexin and longevity
- Sequential sectoral conjunctival epitheliectomy (SSCE)
- Activation of developmental signaling pathways in hematopoietic Stem cell regeneration
- Somatic and germline genetics at the JAK2 locus
- Kinetics of normal hematopoietic Stem and progenitor cells in a Notch1-induced leukemia model
- Rac1 Is Required for Epithelial Stem cell Function during Dermal and Oral
- MicroRNA profiling reveals age-dependent differential expression of nuclear factor κB and mitogen-activated protein kinase in adipose and bone marrow …
- Epigenetic regulation of satellite cell activation during muscle regeneration
- Antithymocyte globulin and cyclosporine for severe aplastic anemia: association between hematologic response and long-term outcome
- Essential biology of Stem cell transplantation
- Regulatory circuitries coordinated by transcription factors and microRNAs at the cornerstone of hematopoietic Stem cell self-renewal and differentiation
- Repopulating Activity of Ex Vivo‐Expanded Murine Hematopoietic Stem Cells Resides in the CD48−c‐Kit+Sca‐1+Lineage Marker− cell Population
- Retroviral expression of arginine decarboxylase attenuates oxidative burden in mouse cortical neural Stem cells
- A reappraisal by quantitative flow cytometry analysis of PTEN expression in acute leukemia
- Searching for adult Stem cells in the intestine
- Aging, exercise, and endothelial progenitor cell clonogenic and migratory capacity in men
- The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary Stem cells
- Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic Stem cells in glioblastoma
- Growth factors and the molecular control of haematopoiesis
- BMI1 confers radioresistance to normal and cancerous neural Stem cells through recruitment of the DNA damage response machinery
- MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic Stem cells
- Chromatin modulation by oncogenic transcription factors: new complexity, new therapeutic targets
- Hemopoietic alterations of cancer
- Clinical challenges and cord blood transplantation: are we asking the right questions?
- Life and death in hematopoietic Stem cells
- The hemoregulatory peptide pEEDCK may inhibit Stem cell proliferation via hydropathic binding to antisense sequence motifs in interleukin-11 and other growth …
- Elucidating the role of metabolic factors in hematopoietic Stem cell maintenance
- Dysfunctional endothelial progenitor cells in chronic kidney disease
- Cancer Stem cells and aneuploid populations within developing tumors are the major determinants of tumor dormancy
- Telomere length and proliferation potential of hematopoietic Stem cells
- Age, caste, and behavior determine the replicative activity of intestinal Stem cells in honeybees (Apis mellifera L.)
- Replicative potential and telomere length in human skeletal muscle: implications for satellite cell -mediated gene therapy
- Aging and disease as modifiers of efficacy of cell therapy
- Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms
- A Runx1 Intronic Enhancer Marks Hemogenic Endothelial Cells and Hematopoietic Stem Cells
- PROSPECT
- Differentiated cells are more efficient than adult Stem cells for cloning by somatic cell nuclear transfer
- Leukemia Stem Cells
- Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex
- Growth Factors Promote High-Dose Chemotherapy
- cell kinetics of CD34‐positive hematopoietic cells following chemotherapy plus colony‐stimulating factors in advanced breast cancer
- Aplastic Anemia & MDS International Foundation (AA&MDSIF): Bone marrow failure disease scientific symposium 2010
- The aryl hydrocarbon receptor has an important role in the regulation of hematopoiesis: implications for benzene-induced hematopoietic toxicity
- Accelerated telomere shortening precedes development of therapy-related myelodysplasia or acute myelogenous leukemia after autologous transplantation …
- Intratibial injection of an anti-doxorubicin monoclonal antibody prevents drug-induced myelotoxicity in mice
- Investigating The Role Of Runx1 In Hair Follicle Stem cell Development And Homeostasis
- cell cycle, CDKs and cancer: a changing paradigm
- Protective effects of BB-10010 treatment on chemotherapy-induced neutropenia in mice
- The Paton Lecture: Ocular Surface Transplantation 10 Years’ Experience
- Idiopathic Aplastic Anemia
- Mast cell growth factor enhances multilineage hematopoietic recovery in vivo following radiation-induced aplasia
- Growth factors and hematopoietic recovery
- 7 Growth inhibitors in haemopoiesis and leukaemogenesis
- Simultaneous knockdown of p18INK4C, p27Kip1 and MAD1 via RNA interference results in the expansion of long-term culture-initiating cells of murine bone marrow …
- Granulocyte colony–stimulating factor administration: adverse events
- Stem cells and cancer: evidence for bone marrow Stem cells in epithelial cancers
- Shp-2 heterozygous hematopoietic Stem cells have deficient repopulating ability due to diminished self-renewal
- Leukemia Stem Cells, A Pioneering Paradigmatic Model
- Regulation of reactive oxygen species and genomic stability in hematopoietic Stem cells
- mTOR: from growth signal integration to cancer, diabetes and ageing
- Bone marrow failure syndromes
- Dyskerin, telomerase and the DNA damage response
- The road to commitment: lineage restriction events in hematopoiesis
- Skeletal muscle Stem cells: effects of aging and metabolism on muscle regenerative function
- 22 THE NORMAL BONE MARROW AND MANAGEMENT OF TOXIN-INDUCED Stem cell FAILURE
- Targeting leukemia Stem cells: The new goal of therapy in adult acute myeloid leukemia
- Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1B β and TSLC1 in neuroblastoma
- cell cycle regulation in hematopoietic Stem cells
- HLA-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results
- EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer
- Phenotypic and Functional Changes in Cord Blood Stem cell Progeny after Cytokine Activation
- Lentiviral gene transfer regenerates hematopoietic Stem cells in a mouse model for Mpl-deficient aplastic anemia
- In vitro expansion of CD34+ cells mobilized with chemotherapy and G-CSF
- Conditional induction of the telomerase reverse transcriptase protein and effects on Stem cell division in vivo
- Replicative senescence and cell immortality: the role of telomeres and telomerase
- Histone deacetylase inhibitors in the treatment of muscular dystrophies: epigenetic drugs for genetic diseases
- Same‐day determination of chimaeric status in the immediate period following allogeneic bone marrow transplantation
- Deletion of Puma protects hematopoietic Stem cells and confers long-term survival in response to high-dose γ-irradiation
- Epigenetic therapy
- The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis
- Stem cells and cancer in the aerodigestive tract
- Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells
- Leukemia Stem cells and new strategies to overcome resistance to therapy
- PUMA kills Stem cells to stall cancer?
- Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features
- Growth factor changes in ex vivo expansion of human limbal epithelial cells on human amniotic membrane
- cell cycle control and check points in hematopoietic Stem cells
- Ovarian cancer plasticity and epigenomics in the acquisition of a Stem-like phenotype
- Practical Use of Hematopoietic Growth Factors in HIV Infection
- Novel Treatment Options
- Replicative senescence of mesenchymal Stem cells causes DNA-methylation changes which correlate with repressive histone marks
- Genetic Regulation of Hematopoietic Stem cell Numbers in Mice
- The biology of cancer Stem cells
- Self-renewal of primitive hematopoietic cells: a focus on asymmetric cell division
- The Tetrapeptide Acetyl-N-Ser-Asp-Lys-Pro (Goralatide) Protects From
- 2006 Kent Award Lecture: Is cell death and replacement a factor in aging?
- Transcriptional and epigenetic regulation of B cell development
- Cigarette Smoke Triggers Code Red: p21CIP1/WAF1/SDI1 Switches on Danger Responses in the Lung
- cell Cycle-Related Changes in Repopulating Capacity of Human Mobilized Peripheral Blood CD34+ Cells in Non-Obese Diabetic/Severe Combined Immune …
- degree of Doctor of Philosophy (Ph. D.)
- Research on Hutchinson-Gilford progeria syndrome
- TOR-driven aging: speeding car without brakes
- Prolonged cell Cycle Transit Is a Defining
- The BALANCE Study: clinical benefit and long-term outcome after intracoronary autologous bone marrow cell transplantation in patients with acute myocardial …
- Mobilization of Peripheral Blood Stem Cells from Normal Donors
- Angiopoietin1 contributes to the maintenance of cell quiescence in EVI1high leukemia cells
- Mobilization and transplantation of peripheral blood Stem cells
- The role of telomere biology in bone marrow failure and other disorders
- Telomere biology of human hematopoietic Stem cells
- Haemopoietic defect and decreased expansion potential of bone marrow autografts from patients with acute myeloid leukaemia in first remission
- Wnt signaling regulates hepatic metabolism
- Epigenetic dysregulation in cancer
- The DNA-damage response in human biology and disease
- Pharmacologic Induction of CD8+ T cell Memory: Better Living Through Chemistry
- Mice severely deficient in growth hormone have normal hematopoiesis
- Erythropoiesis in murine long‐term bone‐marrow cell cultures: Dependence on erythropoietin and endogenous production of an erythropoietic stimulating activity
- Mobilization of Pheripheral Blood Stem Cells from Normal Donors
- Empowering adult Stem cells for myocardial regeneration
- Short-term injection of antiapoptotic cytokine combinations soon after lethal γ-irradiation promotes survival
- Overview of hemopoiesis and hemopoietic reconstruction
- Factors that may impact on immunosenescence: an appraisal
- Dietary Restriction: A Model SyStem Probing the cell Fate Decision Between Cancer and Senescence
- Lineage-specific hematopoietic growth factors
- Protection from arabinofuranosylcytosine and n-mustard-induced myelotoxicity using hemoregulatory peptide pGlu-Glu-Asp-Cys-Lys monomer and dimer
- Modeling notch signaling in normal and neoplastic hematopoiesis: global gene expression profiling in response to activated notch expression
- Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic Stem cells
- Functional analysis of the homeobox gene HOXB4 in primitive hematopoietic cells
- Changing concepts in the management of severe ocular surface disease over twenty-five years
- TGFβ signaling in male germ cells regulates gonocyte quiescence and fertility in mice
- Short telomeres resulting from heritable mutations in the telomerase reverse transcriptase gene predispose for a variety of malignancies
- Recurrence of aplastic anemia following cyclophosphamide and syngeneic bone marrow transplantation: evidence for two mechanisms of graft failure
- In Vitro Modifications Induced by Granulocyte-Macrophage Colony-Stimulating Factor in Human Long-Term Bone Marrow Cultures
- Mechanisms of Wnt-and Notch-mediated Stem cell self-renewal
- Cancer Stem cells: the emerging challenge of drug targeting
- An RbAp48-like gene regulates adult Stem cells in planarians
- GM-CSF multiple course priming and long-term administration in newly diagnosed acute myeloid leukemia: Comparison of three different GM-CSF routes and …
- Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging
- Premeiotic germ cell defect in seminiferous tubules of Atm-null testis
- cell cycle regulators and hematopoiesis
- Quantitative analysis of mixed chimerism following allogeneic bone marrow transplantation using telomere flow-FISH
- Senescence and apoptosis in yeast mother cell -specific aging and in higher cells: a short review
- Bid is a positive regulator for donor-derived lymphoid cell regeneration in γ-irradiated recipients
- Peripheral blood progenitor cells versus bone marrow
- Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow
- Transplante alogênico inter vivo de limbo conjuntival com pareamento HLA em doenças bilaterais da superfície ocular: resultados em longo prazo
- Activation of adenosine A3 receptors supports hematopoiesis-stimulating effects of granulocyte colony-stimulating factor in sublethally irradiated mice
- The biology and clinical uses of blood Stem cells
- The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic Stem cells and mature lineage progenitors by protecting from genotoxic stress
- Autologous and allogeneic transplantation with peripheral blood CD34+ cells: a pediatric experience
- Craniofacial Reconstruction and Aging of Human Mesenchymal Stem Cells
- Principles of hematotoxicology: laboratory assessment and interpretation of data
- Telomere dynamics in hematopoietic Stem cells
- Characterisation of the leukemic Stem cell in a murine model of CALM/AF10 positive myeloid leukemia
- cell aging in relation to stress arousal and cardiovascular disease risk factors
- Cytokine receptors, growth factors and cell cycle in human bone marrow and peripheral blood hematopoietic progenitors
- A low level of reactive oxygen species selects for primitive hematopoietic
- RUNX1 regulates the CD34 gene in haematopoietic Stem cells by mediating interactions with a distal regulatory element
- Norc sIGNALLING Is REQUIRED FOR
- Additive effect of TAp63 deficiency on the adrenocortical dysplasia (acd) phenotype
- Protection and selection for gene therapy in the hematopoietic syStem
- Genetic variation in healthy oldest-old
- Haemopoietic Stem cells: their heterogeneity and regulation
- Age-related decline in immunity: implications for vaccine responsiveness
- Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis
- Bone marrow CD34+ cells expanded on human brain endothelial cells reconstitute lethally irradiated baboons in a variable manner
- A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis
- Myelodysplastic syndrome and aplastic anemia: distinct entities or diseases linked by a common pathophysiology?
- Mechanisms of Yin Yang 1 in oncogenesis: the importance of indirect effects
- Mutations of mitochondrial DNA–cause or consequence of the ageing process?
- Efficacy of up-front 5-fluorouracil–epidoxorubicin–cyclophosphamide (FEC) chemotherapy with an increased dose of epidoxorubicin in high-risk breast cancer …
- Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27Kip1 degradation
- Adult-onset, short-term dietary restriction reduces cell senescence in mice
- The emerging roles of forkhead box (Fox) proteins in cancer
- Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic …
- The molecular mechanisms that control thrombopoiesis
- Hematopoietic Effect of Fractions from the Enzyme-Digested colla corii asini on Mice with 5-Fluorouracil Induced Anemia
- The Wnt Receptor
- Stem cells for skeletal muscle repair
- Three-month therapeutic effect of bone marrow mesenchymal Stem cells transplantation on the treatment of X-linked muscular distrophy mice
- The evolution and classification of ocular surface transplantation
- Hematopoietic Stem Cells and Somatic Stem Cells
- Prospective isolation and molecular characterization of hematopoietic Stem cells with durable self-renewal potential
- Pseudo-DNA damage response in senescent cells
- Interferon-γ and tumor necrosis factor-α differentially affect cytokine expression and migration properties of mesenchymal Stem cells
- CDKs and CKIs: molecular targets for tissue remodelling
- Clonality analysis of childhood ALL in remission: no evidence of clonal hematopoiesis
- Aryl hydrocarbon receptor-null allele mice have hematopoietic Stem/progenitor cells with abnormal characteristics and functions
- Biology of bone marrow-derived endothelial cell precursors
- Telomere dysfunction triggers developmentally regulated germ cell apoptosis
- Paroxysmal nocturnal hemoglobinuria: pathophysiology, natural history and treatment options in the era of biological agents
- Issues in the clinical development of recombinant methionyl human granulocyte colony-stimulating factor: A review
- Telomeres and telomerase regulation
- Increased longevity of hematopoiesis in continuous bone marrow cultures derived from NOS1 (nNOS, mtNOS) homozygous recombinant negative mice correlates with …
- Macrophage Inflammatory Protein 1α Attenuates the Toxic Effects of Temozolomide in Human Bone Marrow Granulocyte-Macrophage Colony-forming Cells
- Chemoprotection and selection by chemotherapy of multidrug resistance-associated protein-1 (MRP1) transduced cells
- Radio-and chemoprotection of bone marrow cells by opposite cell cycle-acting cytokines
- Lineage-specific differences in telomere length after bone marrow transplantation
- Panobinostat treatment depletes EZH2 and DNMT1 levels and enhances decitabine mediated de-repression of JunB and loss of survival of human acute leukemia …
- DNA damage and cellular differentiation: more questions than responses
- Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and Marrow Transplantation (EBMT)
- DNMT3b’s Role in Hematopoietic Stem Cells
- Opposing roles of polycomb repressive complexes in hematopoietic Stem and progenitor cells
- Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal
- Macrophage Inflammatory Protein 1 Attenuates the Toxic Effects of Temozolomide in Human Bone Marrow Granulocyte-Macrophage Colony-forming Cells1
- Your use of the JSTOR archive indicates your acceptance of JSTOR’s Terms and Conditions of Use, available at
- Accelerated wound healing by mTOR activation in genetically defined mouse models
- Unexpected Proatherogenic Properties of p21
- Autophagy and aging
- Cotransplantation of third-party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation
- The ageing epigenome: damaged beyond repair?
- Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling
- WNT signaling in adult cardiac hypertrophy and remodeling: lessons learned from cardiac development
- cell death in the nervous syStem
- In vivo haemoprotective activity of tetrapeptide AcSDKP combined with granulocyte‐colony stimulating factor following sublethal irradiation
- Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus
- A continuum model for tumour suppression
- Steel factor coordinately regulates the molecular signature and biologic function of hematopoietic Stem cells
- Myelopoietic response in tumour-bearing mice by an aggregated polymer isolated from Aspergillus oryzae
- Overexpression of the MnSOD transgene product protects cryopreserved bone marrow hematopoietic progenitor cells from ionizing radiation
- Stimulatory effects of polar glycopeptidolipids of Mycobacterium chelonae on murine haematopoietic Stem cells and megakaryocyte progenitors
- EWS-FLI-1 Expression Triggers a Ewing’s Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells
- Microsatellite instability is not an uncommon finding in adult de novo acute myeloid leukemia
- Macrophages in injured skeletal muscle: a perpetuum mobile causing and limiting fibrosis, prompting or restricting resolution and regeneration
- Aging of the Hematopoietic SyStem
- Specific roles of Target of rapamycin in the control of Stem cells and their progeny in the Drosophila ovary
- cell senescence: the future of ageing?
- Circadian‐based effects of AcSDKP, with or without rhG–CSF on hematologic toxicity of chemotherapy in mice
- Aging-associated decline in innate immunity and therapeutic strategies to counteract it
- Characterization of CD62L as a marker of hematopoietic differentiation in adult mice
- Canonical and non-canonical Wnt signaling in hematopoiesis and lymphocyte
- The Role of the DNA Mismatch Repair Pathway in Adult Stem Cells In Vivo
- Retroviral gene therapy in hematopoietic diseases
- Hematopoietic Stem cells: molecular diversification and developmental interrelationships
- Abnormalities of axon growth in human olfactory mucosa
- SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells
- Unexpected proatherogenic properties of p21: beyond cell cycle control?
- Genetic modification of ex-vivo expanded Stem cells for clinical application
- Wnt/β-catenin signaling in normal and cancer Stem cells
- How transcription factors program chromatin—lessons from studies of the regulation of myeloid-specific genes
- Intra-articular injections in capsulitis
- Targeting malignant B cell self-renewal and differentiation
- Graft failure following allogeneic blood and marrow transplant: evidence-based nursing case study review
- Gene transfer of cytidine deaminase protects myelopoiesis from cytidine analogs in an in vivo murine transplant model
- Molecular damage in cancer: an argument for mTOR-driven aging
- Intercellular feedback in hematopoiesis
- Acute myeloblastic leukemia and recombinant granulocyte colony stimulating factor.
- Retrospective Review of Odontogenic Infections at a Tertiary Medical Center: Clinical Correlations Based on Culture and Sensitivity Data
- As a matter of fat: new perspectives on the understanding of age-related bone loss
- Suppression of tumor suppressors in prostate cancer: the emergence of a novel oncogenic pathway
- Management of the hematologic manifestations of HIV disease
- Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis
- ANALYSIS/PROSPECTS
- Stromal pleiotrophin regulates repopulation behavior of hematopoietic Stem cells
- Physiological relevance of cell cycle kinases
- The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs
- Sequential administration of interleukin-3 and granulocyte-macrophage colony-stimulating factor following intensified, accelerated CEE (cyclophosphamide …
- Enrichment of functionally distinct mouse hematopoietic progenitor cell populations using CD62L
- Beta 2 agonists and asthma.
- Blood progenitor cell (BPC) mobilization studied in multiple myeloma, solid tumor and non-Hodgkin’s lymphoma patients after combination chemotherapy and G-CSF
- Sparing of extraocular muscle in aging and muscular dystrophies: a myogenic precursor cell hypothesis
- Towards cure of CML: why we need to know more about CML Stem cells?
- Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
- The Role of Hox Transcription Factors in the Regulation of Hematopoiesis
- Highlights of the 2007 Progeria Research Foundation scientific workshop: progress in translational science
- KRASG12V enhances proliferation and initiates myelomonocytic differentiation in human Stem/progenitor cells via intrinsic and extrinsic pathways
- The molecular basis of cutaneous aging
- MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1α/HIF-1β
- Hyaluronic acid facilitates the recovery of hematopoiesis following 5‐fluorouracil administration
- Epigenetics: prenatal exposure to genistein leaves a permanent signature on the hematopoietic lineage
- Diabetes induced changes in rat mesenchymal Stem cells
- Epigenetic corruption of VDR signalling in malignancy
- Intra-articular injections in capsulitis
- Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against …
- B-lymphocyte commitment: identifying the point of no return
- Effects of recombinant human granulocyte colony‐stimulating factor on leucopenia in zidovudine‐treated patients with AIDS and AIDS related complex, a phase I/II …
- Probing the mitotic history and developmental stage of hematopoietic cells using single telomere length analysis (STELA)
- Ex vivo culture of Fancc-/- Stem/progenitor cells predisposes cells to undergo apoptosis, and surviving Stem/progenitor cells display cytogenetic abnormalities and an …
- Telomere length dynamics in normal and malignant hematopoiesis
- Hematopoietic growth factors in transplantation: Biology and applications
- Reduction in the duration of myelotoxicity associated with radioimmunotherapy with infusions of the hemoregulatory peptide, HP5b in mice
- Recombinant human granulocyte colony-stimulating factor in the management of cancer patients: five years on
- Hematopoietic Stem cells
- Intrinsic and Microenvironmental Defects Are Involved in the Age-Related Changes of Lin−c-kit+ Hematopoietic Progenitor Cells
- Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles
- Apoptotic regulation in primitive hematopoietic precursors
- Theories and mechanisms of aging
- 11 Blood compared to marrow as a source of allogeneic hematopoietic Stem cells for
- RUNX1 Mutations in Clonal Myeloid Disorders: From Conventional Cytogenetics to Next Generation Sequencing, A Story 40 Years in the Making
- Without Hemopoietic cell Support
- Human somatic mutation rate estimated from SNP chips
- The use of hematopoietic growth factors to support cytotoxic chemotherapy for patients with breast cancer
- Telomere dynamics in childhood leukemia and solid tumors: a follow-up study
- EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence
- Polycomb protein Ezh2 regulates pancreatic β-cell Ink4a/Arf expression and regeneration in diabetes mellitus
- The role of DNA damage and repair in aging: new approaches to an old problem
- Proliferation Society Meeting
- The polycomb gene BMI1 in normal hematopoiesis and leukemia
- The high functionalization of temperature-responsive culture dishes for establishing advanced cell sheet engineering
- Haemopoietic growth factors and dose intensity in high-grade and intermediate-grade lymphoma
- Eosinophils, but not neutrophils, exibit an efficient DNA repair machinary and high nucleolar activity
- PTEN loss in the continuum of common cancers, rare syndromes and mouse models
- Insulin signaling and life span
- Polycomb proteins in mammalian cell differentiation and plasticity
- The genetics of dyskeratosis congenita
- Stimulation of myelopoiesis in Lister a monocytogenes-infected mice by an aggregated polymer isolated from Asp ergillus oryzae
- High-efficiency retroviral gene transfer into murine high-proliferative-potential cells cycle-activated by cytosine arabinoside
- Perturbation in the ability of bone marrow stroma from patients with acute myeloid leukemia but not chronic myeloid leukemia to support normal early hematopoietic …
- Emerin and the nuclear lamina in muscle and cardiac disease
- Radiation-induced Hemopoietic and Immune Dysfunction
- Telomere length in Hutchinson-Gilford progeria syndrome
- A Randomized Phase-II Study of BB-10010 (Macrophage Inflammatory Protein-1) in Patients With Advanced Breast Cancer Receiving 5-Fluorouracil, Adriamycin …
- Anemia, Paroxysmal Nocturnal Hemoglobinuria, Pure Red Blood cell
- Cancer Initiating Cells in Head and Neck Squamous cell Carcinoma
- Therapy with recombinant human erythropoietin in patients with myelodysplastic syndromes
- XXIII International Association for Comparative Research on Leukemia and Related Diseases Symposium: from Molecular Pathogenesis to Targeted Therapy in …
- An examination of ethical issues raised in the pretreatment of normal volunteer granulocyte donors with granulocyte colony-stimulating factor
- Telomere binding proteins including TRF1 and TRF2 (indicated by light and
- Granulocyte colony-stimulating factor (G-CSF) prevents dose-limiting neutropenia in lymphoma patients receiving standard dose chemotherapy
- Reduction in carboplatin hematopoietic toxicity in tumor bearing mice: comparative mechanisms and effects of interleukin-1β and corticosteroids
- Functions of Pleiotrophin in the Regulation of Hematopoiesis
- Therapy for Fanconi Anemia
- HGPS and related premature aging disorders: from genomic identification to the first therapeutic approaches
- Hematopoietic growth factors in cancer treatment
- Ku, Artemis, and ataxia-telangiectasia-mutated: signalling networks in DNA damage
- Defective Notch activation in microenvironment leads to myeloproliferative disease
- Myostatin Propeptide Gene Delivery by Adeno-Associated Virus Serotype 8 Vectors Enhances Muscle Growth and Ameliorates Dystrophic Phenotypes in mdx Mice
- The role of haemopoietic growth factors in bone marrow transplantation
- The role of hematopoietic growth factors in small cell lung cancer: a review
- Pathophysiology and treatment of acquired
- Recombinant human interleukin-1 receptor antagonist protects early myeloid progenitors in a murine model of cyclophosphamide-induced myelotoxicity
- NCI’s provocative questions on cancer: some answers to ignite discussion
- Regulation of senescence in cancer and aging
- Telomere elongation followed by telomere length reduction, in leukocytes from divers exposed to intense oxidative stress–implications for tissue and organismal aging
- Diffuse plasmacytosis in a child with brainStem glioma following multiagent chemotherapy and intensive growth factor support
- The design of differentiation therapies
- Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone …
- The p38 mitogen-activated protein kinase pathway in interferon signal transduction
- Vascular progenitor cells: origin and mechanisms of mobilization, differentiation, integration, and vasculogenesis
- The role of apoptosis, proliferation, and the Bcl-2–related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS
- Telomeres and telomerase in adrenocortical tissue maintenance, carcinogenesis, and aging
- Identification and Characterization of Tumour Initiating Cells From Gynaecological Malignancies
- Pretreatment with granulocyte colony-stimulating factor reduces myelopoiesis in irradiated mice
- Effects of adenosine A3 receptor agonist on bone marrow granulocytic syStem in 5-fluorouracil-treated mice
- Biology of the Mi-2/NuRD complex in SLAC (Stemness, longevity/ageing, and cancer)
- Frequency Analysis of Multidrug Resistance-1 Gene Transfer into Human Primitive Hematopoietic Progenitor Cells Using the Cobblestone Area-Forming cell Assay …
- Epigenetic factors in cancer development: polycomb group proteins
- Genomic instability in incuded Stem cells and regulation of P14ARF expression
- Final checkup of neoplastic DNA replication: Evidence for failure in decision-making at the mitotic cell cycle checkpoint G1/S
- Transient monoparesis following blade plate removal in a Hutchinson-Gilford progeria syndrome patient. A case report
- Aging and cancer: can mTOR inhibitors kill two birds with one drug?
- Theoretical Paper: Exploring Overlooked Natural Mitochondria-Rejuvenative Intervention: The Puzzle of Bowhead Whales and Naked Mole Rats
- General introduction: Epigenetic programming by Polycomb group (PcG) proteins throughout development
- Erythropoietin and Wnt1 govern pathways of mTOR, Apaf-1, and XIAP in inflammatory microglia
- Basic Science of Breast Cancer in Older Patients
- Defective DSB repair correlates with abnormal nuclear morphology and is improved with FTI treatment in Hutchinson-Gilford progeria syndrome fibroblasts
- TOR signaling never gets old: aging, longevity and TORC1 activity
- Akt signaling maintains survival and proliferation in immature T cells and hematopoietic Stem cells
- Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
- CXCR4 and mobilization of hematopoietic precursors
- The regulation of mammary prolactin receptor metabolism by a retroviral envelope protein
- PI3Kδ inhibitors in cancer: rationale and serendipity merge in the clinic
- The role of the homeobox gene Hhex in definitive hematopoietic progenitor proliferation and differentiation
- The importance of the telomere and telomerase syStem in hematological malignancies
- Anatomy and physiology of hematopoiesis
- Analysis of developmentally programmed changes in hematopoietic Stem cells
- The Role of BMP Signaling and Endoglin in Regulation of Hematopoiesis
- Large scale gene expression profiles of regenerating inner ear sensory epithelia
- Genetically determined syndromes associated with premature aging
- The regulation of self-renewal in hematopoietic regeneration and malignancy
- Dose adjustment and supportive care before and during treatment
- A phase I/II trial of recombinant granulocyte-macrophage colony-stimulating factor for children with aplastic anemia
- Gene expression profiling for adult human olfactory neuroepithelial-derived progenitors
- Growth-inhibiting N-substituted endogenous peptides
- Alpha sarcoglycan is required for FGF-dependent myogenic progenitor cell proliferation in vitro and in vivo
- Current status of retroviral vector mediated gene transfer into human hematopoietic Stem cells
- The DNA damage response: making it safe to play with knives
- Requirement of the transcription factor and onco-protein Gfil for the development and function of hematopoietic Stem cells and progenitor cells
- EZH2 is over-expressed in SCLC as a result of genomic deregulation of the Rb/E2F pathway.
- EZH2 depletion blocks the proliferation of colon cancer cells
- Identification and characterisation of novel haemopoietic gene products derived from murine embryonal Stem cells
- Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies
- Laminopathies and A-type lamin-associated signalling pathways
- Control of mRNA Translation in Erythropoiesis
- Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals
- The role of the transcription factor 3 gene product E47 in multipotent hematopoietic Stem cells and progenitors
- Therapeutic Modulation of DNA Damage and Repair Mechanisms in Blood Cells
- Stromal cell –immune cell interactions
- Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis
- Therapy Approach of Neurodegenerative Disorders by Bone Marrow Stem Cells
- Aging and TOR: interwoven in the fabric of life
- DNA damage, somatic aneuploidy, and malignant sarcoma susceptibility in muscular dystrophies
- Mouse models in aging research
- Disposable end tidal carbon dioxide detectors.
- Transcription factors, chromatin and cancer
- T cell function in the aged: Lessons learned from animal models
- FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis
- A phase I/II trial of recombinant human interleukin‐6 in patients with aplastic anaemia
- Hyphal Development in Candida albicans Requires Two Temporally Linked Changes in Promoter Chromatin for Initiation and Maintenance
- Stress responses of human dermal fibroblasts exposed to zinc pyrithione
- Walking in old age and development of metabolic syndrome: the health, aging, and body composition study
- The latest waves in calcium signaling
- Leukemias: principles and practice of therapy
- Alterations in chromatin are associated with increases in collagen III expression in aging nephropathy
- Accelerated features of age-related bone loss in zmpste24 metalloproteinase-deficient mice
- Embryonic senescence and laminopathies in a progeroid zebrafish model
- Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H2O2 Signaling
- The investigation of macrophage inflammatory protein-1α as a myeloprotective agent
- A panel of monoclonal antibodies against human polycomb group proteins
- Effects of caloric restriction on cell proliferation in several tissues in mice: role of intermittent feeding
- The Hematopoietic Microenvironment
- 752Tissue Regeneration and Wound Healing
- Duchenne muscular dystrophy gene therapy: Lost in translation?
- Regulation of immune responses and hematopoiesis by the Rap1 signal
- Gene transfer of multidrug resistance into a factor-dependent human hematopoietic progenitor cell line: in vivo model for genetically transferred chemoprotection
- Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors
- Genetic and pharmacologic regulation of cyclin dependent kinase 4 and 6 activity in mammalian hematopoiesis
- Physical activity and telomere biology: exploring the link with aging-related disease prevention
- Hypertension, obesity, and inflammation: the complex designs of a deadly trio
- 13 Aging and Intrinsic Aging: Pathogenesis and Manifestations
- Postgraduate haematology
- Gene transfer of multidrug resistance into a factor-dependent human hematopoietic progenitor cell line: in vivo…
- Bridging the gap between clinical trials of antiplatelet therapies and applications among elderly patients
- The effect of vascular aging on cancer progression and metastasis
- PI3K/mTOR signaling regulates prostatic branching morphogenesis
- Pancytopenia and the hypocellular bone marrow
- Workshop on immunizations in older adults: identifying future research agendas
- Early Blood cell Formation
- The role of the histone methyltransferase egg/dSETDB1 in Drosophilia development and oogenesis
- Hematologic Disorders in the Elderly
- Fragments of functional proteins: role in endocrine regulation
- Cytokine regulation of hematopoietic Stem cells and lymphopoiesis
- Effects of white adipose tissue grafts on total body fat and cellularity are dependent on graft type and location
- Spontaneous abrogation of the G2 DNA damage checkpoint has clinical benefits but promotes leukemogenesis in Fanconi anemia patients
- Biodegradabable [sic] endovascular stents: fulfilling the mission and then stepping away
- Analysis of murine mammary epithelial cellular hierarchy
- Chemoprotection by transfer of resistance genes
- Statin’s excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling
- Distinct Roles of Cellular Copper and Erythropoietin Receptor on Hematopoietic Engraftment
- Lehrstuhl für Entwicklungsgenetik
- The role of the TSC-mTOR pathway on the regulation of the hematopoietic Stem cells
- Characterization of perforin and Fas ligand effector and regulatory T cell functions in allogeneic bone marrow transplantation
- G1 phase control and cell differentiation
- The effects of physiological adaptations to calorie restriction on global cell proliferation rates
- Programmed cell Death and Its Role in Neurological Disease
- PI3K𝛅 Inhibitors in Cancer: Rationale and Serendipity Merge in the Clinic
- Handbook of Experimental Pharmacology
- Telomeres: hallmarks of radiosensitivity
- The role of telomerase in age-related degenerative disease and cancer
- Animal models of human genetic diseases: do they need to be faithful to be useful?
- The role of mTOR signaling in controlling mammalian life span: what a fungicide teaches us about longevity
- DNA Damage
- The Influence of MIP-1α and Its Receptors in Haemopoiesis
- Chromatin structure regulation in transforming growth factor-β-directed epithelial-mesenchymal transition
- Regulation of Stem cells and neurogenesis in the adult olfactory epithelium
- Identification, isolation and ex vivo expansion of haemopoietic progenitor and Stem cells
- Polycomb group protein Ezh2 regulates pancreas regeneration and neoplasia
- Mouse models for understanding the molecular mechanism of bone disease in Hutchinson-Gilford progeria syndrome
- Double Strand Break Signaling in Health and Diseases
- Bibliography Current World Literature Vol 14 No 4 July 2007
- CLINICAL RESEARCH PROJECT
- Telomere length and dynamics in Hutchinson-Gilford progeria syndrome
- Effects of Physiologic, Metabolic and Molecular Adaptations to Calorie Restriction on Biomarkers of Longevity
- Roles for E2F in mouse hematopoiesis and pancreas homeostasis
- 1 3 Hematopoietic Growth Factors
- The role of the RhoA/rho-kinase pathway in pulmonary hypertension
- Osteogenesis imperfecta
- Genomic approaches for pathway identification in regenerating sensory epithelia of the inner ear
- Les syndromes lipodystrophiques: des adipopathies congénitales ou acquises
- Nuclear lamins: major factors in the structural organization and
- International Workshop” From Homo sapiens to Homo sapiens liberatus
- cell cycle and cancer: the G1 restriction point and the G1/S transition
- TO ALLOMETRY AND SURVIVORSHIP
- The Role of CDKs in Normal and Neoplastic Proliferation
- Mechanisms of Gfi-1 mediated transcriptional repression
- Non-integrating integrase and long terminal repeat attachment site mutant HIV-1-derived lentiviral vectors
- Cancer Genome and DNA Repair
- Cancer, Senescence, and Aging: Translation from Basic Research to Clinics
- hGTSE-1 Protein Unveils a New Pathway that Regulates p21CIP1/WAF1 Stability and Subcellular Localization
- Role of the Transcription Factor Zfx in T cell Homeostasis
- Phospho-regulation of the DNA Damage Response Kinase ATR
- Spatial, temporal and reversible regulation of endogenous genes in vivo using RNA interference
- Genetic studies of familial myeloproliferative disorders
- Accelerated aging in COPD: the relationship of telomere length and mortality in COPD
- Investigations of Polyamine Function Using Transgenic Mouse Models with Spermidine Synthase and S-adenosylmethionine Decarboxylase Overexpression
- hGTSE1 protein unveils new pathways that regulate apoptosis and cell motility
- DNA sequence and chromatin directed compartmentalization of chromosomal domains to the nuclear lamina
- Role of the MUTYH protein in the response to oxidative damage to DNA
- Characterisation of the role of the transcription factor Gfi-1B in haematopoiesis
- JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 33 (4): 474-482, 2006 UMCG Disciplinegroep: NUC Annovazzi, A., Bonanno, E., Arca, M., D’ …
- The effect of maternal malaria during pregnancy on birth size, early childhood growth and blood pressure in Nigerian children
- Macrophage Inflammatory Protein-1&alpha: An Inhibitor of Clonogenic Epidermal Keratinocyte Proliferation?
- CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and Stem cell exhaustion
- Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult Stem cell exhaustion
- Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic Stem cell exhaustion and development of a myeloproliferative …
- C/EBPβ promotes BCR–ABL-mediated myeloid expansion and leukemic Stem cell exhaustion
- Age-specific bone tumour incidence rates are governed by Stem cell exhaustion influencing the supply and demand of progenitor cells
- Control of the epithelial Stem cell epigenome: the shaping of epithelial Stem cell identity
- aPKCλ controls epidermal homeostasis and Stem cell fate through regulation of division orientation
- Reactive oxygen species regulate hematopoietic Stem cell self-renewal, migration and development, as well as their bone marrow microenvironment
- Hematopoietic Stem cell expansion: challenges and opportunities
- Megakaryocytes in the hematopoietic Stem cell niche
- Disseminated Mycobacterium Avium Infection Accelerates Hematopoietic Stem cell exhaustion
- C/EBPβ promotes BCR-ABL-mediated myeloid expansion and leukemic Stem cell exhaustion
- Genetic control of quiescence in hematopoietic Stem cells
- Akt signaling leads to Stem cell activation and promotes tumor development in epidermis
- Functional intestinal Stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1)
- Smurf2 regulates hematopoietic Stem cell self‐renewal and aging
- The intestinal crypt, a prototype Stem cell compartment
- Increasing Stem cell dose promotes the longevity of the graft in mice transplanted with human cord blood Stem cells
- Hematopoietic Stem cell Expansion, without exhaustion or Transformation, by Stable Microrna Antagonism in Vivo
- Cyclin E1 regulates hematopoietic Stem cell quiescence
- The control of hematopoietic Stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation
- Rapamycin increases oxidative stress response gene expression in adult Stem cells
- Polycomb Cbx family members mediate the balance between haematopoietic Stem cell self-renewal and differentiation
- PTEN expression and function in adult cancer Stem cells and prospects for therapeutic targeting
- 2 Age-specific bone tumour incidence rates are governed by Stem cell 3 exhaustion influencing the supply and demand of progenitor cells
- Relief with rapamycin: mTOR inhibition protects against radiation-induced mucositis
- Aging and epigenetic drift: a vicious cycle
- Adult Stem cells for chronic lung diseases
- Mechanistic links between aging and lung fibrosis
- miR-146a regulates hematopoietic Stem cell maintenance and cell cycle entry
- p57 controls adult neural Stem cell quiescence and modulates the pace of lifelong neurogenesis
- Hematopoietic Stem cell niche maintenance during homeostasis and regeneration
- The hallmarks of aging
- Oxymetholone Therapy of Fanconi Anemia Induces Hematopoietic Stem cell Cycling By Suppressing Osteopontin Transcription
- Developing a syStems-based understanding of hematopoietic Stem cell cycle control
- Long-term hematopoietic Stem cell damage in a murine model of the hematopoietic syndrome of the acute radiation syndrome
- Epigenetics of hematopoietic Stem cell aging and disease
- Adult Stem cells and diseases of aging
- Deletion of Nono, a Novel Double-Strand Break Repair Factor, Leads to Hematopoietic Stem cell Defects
- Molecular regulation of Stem cell quiescence
- mEst1A (mouse Ever Shorter Telomeres 1A) regulates telomere length and RNA quality control in murine Stem cells
- DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells
- The Role of Innate Immune Dysfunction in Inherited Bone Marrow Failure
- Regulation of hematopoietic Stem cell fate by the ubiquitin proteasome syStem
- Concise review: Stem cell therapy for muscular dystrophies
- Homeodomain transcription factor Meis1 is a critical regulator of adult bone marrow hematopoiesis
- Hematopoietic Stem cell expansion
- The transcriptional corepressorTle4 is a novel regulator of murine hematopoietic Stem and progenitor cells and their niche
- The hematopoietic Stem cell niche
- PRMT5 Methyltransferase Activity Is Required to Sustain Adult Hematopoiesis
- MicroRNAs as mediators of the ageing process
- Stem cell aging: mechanisms, regulators and therapeutic opportunities
- Fate through fat: lipid metabolism determines Stem cell division outcome
- Energy metabolism and metabolic sensors in Stem cells: the metaboStem crossroads of aging and cancer
- Myelodysplastic syndrome-associated cytogenetic abnormalities: case report
- Arteriolar niches maintain haematopoietic Stem cell quiescence
- Regulation of Axial Stem Cells Deriving Neural and Mesodermal Tissues During Posterior Axial Elongation
- MicroRNA-141-3p plays a role in human mesenchymal Stem cell aging by directly targeting ZMPSTE24
- Metabolic plasticity and hematopoietic Stem cell biology
- Mouse hematopoietic Stem cell transplantation
- Polycomb repressive complex 2 regulates normal hematopoietic Stem cell function in a developmental-stage-specific manner
- Metabolic requirements for the maintenance of self-renewing Stem cells
- Neurogenesis in the embryonic and adult brain: same regulators, different roles
- Stem cell metabolism in tissue development and aging
- mTOR inhibition prevents epithelial Stem cell senescence and protects from radiation-induced mucositis
- Chronic kidney disease: a clinical model of premature aging
- Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema
- Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic Stem cell aging
- Regulation of plant Stem cell quiescence by a brassinosteroid signaling module
- Regulators of the proliferation of hematopoietic Stem and progenitor cells during hematopoietic regeneration
- Mutant U2AF1 expression alters hematopoiesis and Pre-mRNA splicing in transgenic mice
- Dystrophin and utrophin “double knockout” dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities
- Fibroblast growth factor signaling promotes physiological bone remodeling and Stem cell self-renewal
- The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic Stem cell self-renewal and transformation
- Myeloid translocation gene 16 is required for maintenance of haematopoietic Stem cell quiescence
- Increased Incidence of Lymphosarcoma in Long-Term Murine Survivors of Lethal Radiation: A Classification of Subtypes
- Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging
- Stem cell dynamics in Macrostomum lignano (Platyhelminthes) during homeostasis and regeneration
- Stem cell senescence and regenerative paradigms
- Induced pluripotent Stem cell model of chronic myeloid leukemia revealed olfactomedin 4 as a novel therapeutic target in leukemia Stem cells
- Molecular Mechanisms of Muscle Stem cell Aging
- Akt modes of Stem cell regulation: more than meets the eye?
- Chronic myeloid leukemia: the possibility of a cure
- Continuous clonal labeling reveals small numbers of functional Stem cells in intestinal crypts and adenomas
- Chromosome instability underlies hematopoietic Stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation
- cell cycle regulators in Stem cells
- Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic Stem cell function
- Accumulation of DNA damage-induced chromatin alterations in tissue-specific Stem cells: the driving force of aging?
- Serial transplantation of bone marrow to test self-renewal capacity of hematopoietic Stem cells in vivo
- Mimicking the functional hematopoietic Stem cell niche in vitro: recapitulation of marrow physiology by hydrogel-based three-dimensional cultures of …
- Transcriptional repression of Bmp2 by p21Waf1/Cip1 links quiescence to neural Stem cell maintenance
- A unifying hypothesis on mammalian neural Stem cell properties in the adult hippocampus
- Adult Hematopoietic Stem Cells: Niche Cross-Talks to Affect the cell Fate
- Dietary and metabolic control of Stem cell function in physiology and cancer
- Stem cell therapies for muscle disorders
- Hematopoietic Stem cell Aging and Cancer
- Energy metabolism and energy-sensing pathways in mammalian embryonic and adult Stem cell fate
- The retinoblastoma tumor suppressor and Stem cell biology
- Aging alters tissue resident mesenchymal Stem cell properties
- Hematopoietic Stem cell development: an epigenetic journey
- From Stem cells to cancer Stem cells: HIF takes the stage
- Proteostasis and aging of Stem cells
- Age-related cognitive decline: can neural Stem cells help us?
- Regulation of Hematopoietic Stem cell Fate: Self-Renewal, Quiescence and Survival
- Effect of Evaporative Stress on Meibomian Gland Proliferative Status and Lipid-Protein Composition
- Prox1 promotes expansion of the colorectal cancer Stem cell population to fuel tumor growth and ischemia resistance
- Prelamin A accumulation and stress conditions induce impaired Oct-1 activity and autophagy in prematurely aged human mesenchymal Stem cell
- Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic Stem cell expansion
- Extracellular matrix: a dynamic microenvironment for Stem cell niche
- NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic Stem cell functions
- Adult neural Stem cells bridge their niche
- The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic Stem cell function
- Slow-cycling Stem cells in hydra contribute to head regeneration
- Kinase-inhibitor–insensitive cancer Stem cells in chronic myeloid leukemia
- Tissue-specific Stem cells: lessons from the skeletal muscle satellite cell
- Maintenance of leukemia-initiating cells is regulated by the CDK inhibitor Inca1
- Hes1 mediates the different responses of hematopoietic Stem and progenitor cells to T cell leukemic environment
- Age-associated alterations of pleiotropic Stem cell and the therapeutic implication of Stem cell therapy in aging
- Dormancy, Quiescence, and Cellular Senescence
- The polycomb protein Ezh2 impacts on induced pluripotent Stem cell generation
- Induced cancer Stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer Stem cell
- Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow
- Adult Stem cell and mesenchymal progenitor theories of aging
- Aged Human Cells Rejuvenated by Cytokine-Enhancement of Biomaterials for Surgical Ventricular Restoration
- Polycomb repressive complex 2 regulates hematopoietic Stem cell maintenance and differentiation in a developmental stage-specific manner
- Regenerating the skin: a task for the heterogeneous Stem cell pool and surrounding niche
- Fibrosis and renal aging
- Cdc42 and aging of hematopoietic Stem cells
- Deconstructing mTOR complexes in regulation of Glioblastoma Multiforme and its Stem cells
- Transcriptional analysis of histone deacetylase family members reveal similarities between differentiating and aging spermatogonial Stem cells
- Lamina-associated polypeptide (LAP) 2α and nucleoplasmic lamins in adult Stem cell regulation and disease
- EZH2 and KDM6A Act as an Epigenetic Switch to Regulate Mesenchymal Stem cell Lineage Specification
- Genetic and pharmacologic inhibition of β-catenin targets imatinib-resistant leukemia Stem cells in CML
- TBK1 regulates prostate cancer dormancy through mTOR inhibition
- Hematopoietic Stem cell Aging and Fate Decision
- Human ES-and iPS-derived myogenic progenitors restore DYSTROPHIN and improve contractility upon transplantation in dystrophic mice
- DNA damage checkpoints in Stem cells, ageing and cancer
- Progerin expression disrupts critical adult Stem cell functions involved in tissue repair
- Dynamic changes in Ezh2 gene occupancy underlie its involvement in neural Stem cell self-renewal and differentiation towards oligodendrocytes
- Absence of ductal hyper-keratinization in mouse age-related meibomian gland dysfunction (ARMGD)
- Defects in Glycosylation Impair Satellite Stem cell Function and Niche Composition in the Muscles of the Dystrophic Largemyd Mouse
- Regulation of Plant Stem cell Quiescence by a Brassinosteroid Signaling Module
- A stress-induced cellular aging model with postnatal neural Stem cells
- New Advanced Technologies in Stem cell Therapy
- Clonal evolution of leukemic Stem cells in a Cbx7-induced leukemia mouse model
- Genome-wide analysis of transcriptional regulators in human hscs reveals a densely interconnected network of coding and non-coding genes
- EZH2 in normal and malignant hematopoiesis
- Hutchinson–Gilford progeria syndrome through the lens of transcription
- The impact of JAK-STAT signaling on muscle regeneration
- Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation
- 578 Human Blood and Cardiac Stem Cells Synergize to Enhance Cardiac Repair When Co-Transplanted Into Ischemic Myocardium
- Role of the PTEN signaling pathway in autism spectrum disorder
- Combined usage of Stem cells in end‐stage heart failure therapies
- Bioreactor engineering of Stem cell environments
- Small molecules affect human dental pulp Stem cell properties via multiple signaling pathways
- Telomere biology in Stem cells and reprogramming
- The analysis, roles and regulation of quiescence in hematopoietic Stem cells
- Burn to cycle: energetics of cell -cycle control and Stem cell maintenance
- Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila
- The PI3K/AKT signaling pathway controls the quiescence of the low‐Rhodamine123‐retention cell compartment enriched for melanoma Stem cell activity
- Role of Fbxw7 in the maintenance of normal Stem cells and cancer-initiating cells
- Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here
- Pten deletion in adult hippocampal neural Stem/progenitor cells causes cellular abnormalities and alters neurogenesis
- Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal
- Chronic kidney disease and aging: The theme of world kidney day in 2014; nephrologist will become the professional geriatrist
- Genetic rejuvenation of old muscle
- Adipose-derived Stem cells: methods for isolation and applications for clinical use
- The promising potential of menstrual Stem cells for antenatal diagnosis and cell therapy
- An acute negative bystander effect of γ-irradiated recipients on transplanted hematopoietic Stem cells
- Networks Establishing Hematopoietic Stem cell Multipotency and Self-Renewal
- cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging
- Hematopoietic Stem cells: transcriptional regulation, ex vivo expansion and clinical application
- When Stemness Meets Engineering: Towards “Niche” Control of Stem cell Functions for Enhanced Cardiovascular Regeneration
- Regulation of Stem cell plasticity: mechanisms and relevance to tissue biology and cancer
- Lung epithelial Stem cells and their niches: Fgf10 takes center stage
- Requirement for ssbp2 in hematopoietic Stem cell maintenance and stress response
- Maintenance of hematopoietic Stem cells through regulation of Wnt and mTOR pathways
- The Runx-PU. 1 pathway preserves normal and AML/ETO9a leukemic Stem cells
- Stem cell therapy for idiopathic pulmonary fibrosis: How far are we from the bench to the bedside?
- GATA-2 anomaly and clinical phenotype of a sporadic case of lymphedema, dendritic cell , monocyte, B-and NK-cell (DCML) deficiency, and myelodysplasia
- Plant and animal Stem cells: similar yet different
- Drosophila follicle Stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS
- Inhibition of T cell Protein Tyrosine Phosphatase Enhances Interleukin‐18‐Dependent Hematopoietic Stem cell Expansion
- Division of Rheumatology, Allergy, and Immunology
- A role for RUNX1 in hematopoiesis and myeloid leukemia
- The telomere syndromes
- Congenital amegakaryocytic thrombocytopenia (CAMT) presenting as severe pancytopenia in the first month of life
- Polycomb repressive complex 2 is required for MLL-AF9 leukemia
- Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of Stem cell leukemia
- Heterogeneous distribution of mechanical stress in human lung: a mathematical approach to evaluate abnormal remodeling in IPF
- The regulation of signaling in hematopoietic Stem cell maintenance
- Marking the tempo for myogenesis: Pax7 and the regulation of muscle Stem cell fate decisions
- Umbilical cord mesenchymal Stem cell transplantation for the treatment of diabetes mellitus in rats
- RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis
- Satellite cells: the architects of skeletal muscle
- Brief report: Blockade of Notch signaling in muscle Stem cells causes muscular dystrophic phenotype and impaired muscle regeneration
- Regenerative medicine for the cornea
- Methylene blue promotes quiescence of rat neural progenitor cells
- Stem cells marked by the R-spondin receptor LGR5
- Runx3 deficiency results in myeloproliferative disorder in aged mice
- Cyclin dependent kinase inhibitors differentially modulate synergistic cytokine responsiveness of hematopoietic progenitor cells
- Concurrent transient activation of Wnt/β-catenin pathway prevents radiation damage to salivary glands
- Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors
- Caloric restriction and aging Stem cells: the stick and the carrot?
- Pharmacologic Inhibition of Cardiac Stem cell Senescence
- Stem cells behind the barrier
- Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects
- Mesenchymal Stem cell heterogeneity and ageing in vitro: A model approach
- Molecular and endocrine mechanisms underlying the Stem cell theory of aging
- Characterization of TLX expression in neural Stem cells and progenitor cells in adult brains
- Mitochondria as signaling organelles
- Injection of Vessel-Derived Stem Cells Prevents Dilated Cardiomyopathy and Promotes Angiogenesis and Endogenous Cardiac Stem cell Proliferation in mdx/utrn−/− but Not …
- Hair cycle resting phase is regulated by cyclic epithelial FGF18 signaling
- Muscle-derived Stem/progenitor cell dysfunction in Zmpste24-deficient progeroid mice limits muscle regeneration
- Stimulation of the follicular bulge LGR5+ and LGR6+ Stem cells with the gut-derived human alpha defensin 5 results in decreased bacterial presence, enhanced …
- Progeroid syndromes: models for Stem cell aging?
- Role of casein kinase 1A1 in the biology and targeted therapy of del (5q) MDS
- A dialog on the first 20 years of PML research and the next 20 ahead
- Mesenchymal Stem cells: a promising therapy for the acute respiratory distress syndrome
- Human embryonic Stem cell -derived hematopoietic cells maintain core epigenetic machinery of the polycomb group/trithorax group complexes distinctly from …
- Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5
- The impact of obstetric parameters on haematopoietic Stem cells extracted from the umbilical cord blood in the Chinese population
- Genetic and epigenetic alterations that drive leukemic Stem cell self-renewal
- Genotoxic exposure during juvenile growth of mammary gland depletes Stem cell activity and inhibits Wnt signaling
- Ex vivo expanded hematopoietic Stem cells for ischemia
- The role of DNA repair in the pluripotency and differentiation of human Stem cells
- Telomerase exerts physiological and tumor promoting functions by stimulating ribosomal biogenesis
- Changes in the frequencies of human hematopoietic Stem and progenitor cells with age and site
- Aging and reprogramming: a two-way street
- Geriatric muscle Stem cells switch reversible quiescence into senescence
- Dystrophin-compromised sarcoglycan-δ-knockout diaphragm requires full wild-type embryonic Stem cell reconstitution for correction
- Tumorigenesis in Down’s syndrome: big lessons from a small chromosome
- Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis
- Inhibition of Akt/mTOR attenuates age‐related changes in mesenchymal Stem cells
- Neuroblastoma: Role of MYCN/Bmi1 Pathway in Neuroblastoma
- Epigenetic regulation of hematopoiesis
- Promises and challenges of exhausting pediatric neural cancer Stem cells
- Transcriptional Quiescence of Hematopoietic Stem Cells
- Longevity Pathways in Mammalian Stem Cells
- Sustained Engraftment of Cryopreserved Human Bone Marrow CD34+ Cells in Young Adult NSG Mice
- The diagnosis and treatment of dyskeratosis congenita: a review
- MicroRNA-125 family members exert a similar role in the regulation of murine hematopoiesis
- Predictive factors for successful imatinib cessation in chronic myeloid leukemia patients treated with imatinib
- Suppression of replicative senescence by rapamycin in rodent embryonic cells
- Geroconversion: irreversible step to cellular senescence
- BM Hematopoietic Niche Occupancy Defect of HSC in Scid Mice
- Embryonic Diapause as a Model for Pluripotent Stem cell Quiescence
- Identification and Characterization of Cells with Stem cell Properties in Normal and Malignant Muscle Cultures
- Trithorax and polycomb cooperation in MLL fusion acute leukemia
- Genetic alterations of the mixed lineage leukemia
- Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage
- Understanding telomere diseases through analysis of patient-derived iPS cells
- Bone cell senescence: mechanisms and perspectives
- Cytokine combinations on the potential for ex vivo expansion of murine hematopoietic Stem cells
- Spatial analysis of brassinosteroid signaling in the Stem cell niche of Arabidopsis primary root= Caracterització molecular de la funció de BRI1 en les cèl· lules mare …
- Nutrient-sensing pathways and metabolic regulation in Stem cells
- Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration
- Helen Blau: She Thinks Like a cell
- Understanding The Molecular Mechanisms Of Hair Follicle Stem cell Quiescence And Genome Plasticity
- Control of adult Stem cells in vivo by a dynamic physiological environment: diet‐dependent syStemic factors in Drosophila and beyond
- Engineering skeletal muscle repair
- Regulation of Stem cell Metabolism by the Lin28/let-7 Axis
- Current concerns of undertreatment and overtreatment in chronic myeloid leukemia based on European LeukemiaNet 2013 recommendations
- The Multifaceted Role of Exonuclease 1 in DNA Repair and Adult Stem cell Populations
- EZH2 suppresses hepatocellular differentiation of mouse bone marrow mesenchymal Stem cells
- Efficient tumorigenesis by mutation-induced failure to terminate microRNA-mediated adaptive hyperplasia
- The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation
- Exonuclease 1 is a critical mediator of survival during DNA double strand break repair in nonquiescent hematopoietic Stem and progenitor cells
- The pathogenesis of COPD and IPF: distinct horns of the same devil?
- Stem cell membrane engineering: an approach for modulating cell -biomaterial interactions
- Skin mirrors human aging
- The cytosolic protein G0S2 maintains quiescence in hematopoietic Stem cells
- ROS function in redox signaling and oxidative stress
- Concise review: preleukemic Stem cells: molecular biology and clinical implications of the precursors to leukemia Stem cells
- Altering Fate Determination of Human Bone Marrow-Derived Mesenchymal Stem Cells through Environmental and Transcriptional Cues
- Klotho acts as a tumor suppressor in cancers
- Nrf2, a regulator of the proteasome, controls self‐renewal and pluripotency in human embryonic Stem cells
- Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging
- Early forming label-retaining muscle Stem cells require p27kip1 for maintenance of the primitive state
- Genomic deregulation of the E2F/Rb pathway leads to activation of the oncogene EZH2 in small cell lung cancer
- Satellite cells, the engines of muscle repair
- Transcriptional mechanisms of cell fate decisions revealed by single cell expression profiling
- Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
- The effect of chemotherapy on telomere dynamics: clinical results and possible mechanisms
- Transcriptional control of spermatogonial maintenance and differentiation
- Multifaceted aging and rapamycin
- Developmental exposure to 2, 3, 7, 8 tetrachlorodibenzo-p-dioxin attenuates capacity of hematopoietic Stem cells to undergo lymphocyte differentiation
- Binding to WGR domain by salidroside activates PARP1 and protects hematopoietic Stem cells from oxidative stress
- From” magic bullets” to specific cancer immunotherapy
- Interstitial lung disease
- Evaluation of human MRC-5 cells as a feeder layer in a xenobiotic-free culture syStem for conjunctival epithelial progenitor cells
- Potential of telomerase activation in extending health span and longevity
- microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice
- Kindler syndrome in mice and men
- Telomeres and age-related disease: how telomere biology informs clinical paradigms
- Wnt signalling in an in vitro niche model for conjunctival progenitor cells
- Adaptive inflammatory microenvironment for cell -based regeneration in ischemic cardiovascular disease
- Donor satellite cell engraftment is significantlyaugmented when the host niche is preserved and endogenous satellite cells are incapacitated
- MicroRNAs and epigenetics in adult neurogenesis
- The Role of Polycomb Group Proteins in Hematopoietic Stem cell (HSC) Self-Renewal and Leukemogenesis
- The Role of the In Vivo Microenvironment in Human Stem cell Fate Decisions
- Signaling involved in hair follicle morphogenesis and development
- Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo
- Tissue engineered strategies for skeletal muscle injury
- Genomic analysis of invasive human bone marrow derived mesenchymal Stem cells
- Strange bedfellows: mitotically active chronic myeloid leukemia in molecular complete remission, detected in focal lesion of myeloma
- Engraftment and lineage potential of adult hematopoietic Stem and progenitor cells is compromised following short-term culture in the presence of an aryl hydrocarbon …
- Amniotic Fluid Stem Cells Restore the Muscle cell Niche in a HSA‐Cre, SmnF7/F7 Mouse Model
- CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion
- www. impactaging. com AGING, July 2013, Vol. 5 No 7
- Ras-proximate-1 GTPase-activating protein and Rac2 may play pivotal roles in the initial development of myelodysplastic syndrome
- Mutual Reinforcement Between Telomere Capping and Canonical Wnt Pathway Activity in the Intestinal Stem cell Niche
- Mouse hematopoietic cell –targeted STAT3 deletion: Stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging–like phenotype
- Detection of paroxysmal nocturnal hemoglobinuria clones to exclude inherited bone marrow failure syndromes
- Mitophagy in hematopoietic Stem cells: the case for exploration
- Cdks, cyclins and CKIs: roles beyond cell cycle regulation
- mTOR signaling from cellular senescence to organismal aging
- mTOR signaling in growth control and disease
- Stimulation of Wnt/ß-Catenin Pathway in Human CD8+ T Lymphocytes from Blood and Lung Tumors Leads to a Shared Young/Memory Phenotype
- THE ROLE OF NUMB IN Stem cell HOMEOSTASIS AND BREAST TUMORIGENESIS
- Possible role of autophagy activation in stimulation of regeneration
- Mesenchymal Stem/stromal cells: a new”cells as drugs”paradigm. Efficacy and critical aspects in cell therapy
- Skeletal muscle contractile function and neuromuscular performance in Zmpste24−/− mice, a murine model of human progeria
- Mechanisms of premature cell senescence
- A Wnt-TGFβ2 axis induces a fibrogenic program in muscle Stem cells from dystrophic mice
- Renal Stem cells: fact or science fiction?
- Intervening in ageing to prevent the diseases of ageing
- The humerus of Eusthenopteron: a puzzling organization presaging the establishment of tetrapod limb bone marrow
- Hematopoietic Stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress
- Aufbau und Charakterisierung eines Knochenmark-Stammzellnischen-Modells Development and characterization of a bone marrow Stem cell niche model
- Inducible progenitor‐derived Wingless regulates adult midgut regeneration in Drosophila
- Progeria: a paradigm for translational medicine
- Wnt signaling in skin development, homeostasis, and disease
- Increased expression of PcG protein YY1 negatively regulates B cell development while allowing accumulation of myeloid cells and LT-HSC cells
- Rapid depletion of muscle progenitor cells in dystrophic mdx/utrophin−/− mice
- Adult thymic epithelium contains nonsenescent label-retaining cells
- Cellular differences in protein synthesis regulate tissue homeostasis
- Rescue of murine silica-induced lung injury and fibrosis by human embryonic Stem cells
- Telomeres in lung diseases
- The epigenetic regulator CXXC finger protein 1 is essential for murine hematopoiesis
- Effects of microRNA-31 on skeletal muscle Stem cell self-renewal ex vivo and in vivo
- Stem cells isolated from adipose tissue of obese patients show changes in their transcriptomic profile that indicate loss in Stemcellness and increased …
- Human TEN1 maintains telomere integrity and functions in genome-wide replication restart
- The role of the aryl hydrocarbon receptor in normal and malignant B cell development
- Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent Stem cells derived from FPD/AML patients
- Studying aging in Drosophila
- Regulation of the cyto-architecture in epithelial morphogenesis and homeostasis
- What a difference a hydroxyl makes: mutant IDH,(R)-2-hydroxyglutarate, and cancer
- Oncogenic Nras has bimodal effects on Stem cells that sustainably increase competitiveness
- Current issues in chronic myeloid leukemia: monitoring, resistance, and functional cure
- Balancing Stem cell Self-Renewal and Differentiation in the Skin
- Toll-like receptor alterations in myelodysplastic syndrome
- Chronic TLR signaling impairs the long-term repopulating potential of hematopoietic Stem cells of wild type but not Id1 deficient mice
- Stem Cells Propagate Their DNA by Random Segregation in the Flatworm Macrostomum lignano
- Notch signaling deficiency underlies age-dependent depletion of satellite cells in muscular dystrophy
- Ageing Stem and progenitor cells: implications for rejuvenation of the central nervous syStem
- From innate to adaptive immune response in muscular dystrophies and skeletal muscle regeneration: the role of lymphocytes
- Investigation of Notch Signalling in Drosophila Germline Stem cell Niche
- Graft-versus-host disease causes broad suppression of hematopoietic primitive cells and blocks megakaryocyte differentiation in a murine model
- Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice
- Skeletal muscle tissue engineering: which cell to use?
- WISP1: Clinical insights for a proliferative and restorative member of the CCN family
- Epigenetic Reprogramming in Stem Cells
- Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle
- Metformin: do we finally have an anti-aging drug?
- Brain response to calorie restriction
- Modelling mammalian cellular quiescence
- Current evidence that exercise can increase the number of adult Stem cells
- Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood Stem/progenitor cells
- www. PRSJournal. com 1159
- Gerosuppression in confluent cells
- The epigenetic landscape of acute myeloid leukemia
- Isolation, characterization, and molecular regulation of muscle Stem cells
- The Orphan Nuclear Receptor EAR-2 (NR2F6) is a Leukemia Oncogene and Novel Regulator of Hematopoietic Stem cell Homeostasis and Differentiation
- Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression
- Selective targeting of human colon cancer Stem-like cells by the mTOR inhibitor Torin-1
- Polycomb complexes in Stem cells and embryonic development
- Cardiac Stem cells: biology and clinical applications
- Comparison of epithelial differentiation and immune regulatory properties of mesenchymal stromal cells derived from human lung and bone marrow
- RETRACTED: Bmi1 is critical to prevent Ikaros-mediated lymphoid priming in hematopoietic Stem cells
- Cancer Stem cells and glioblastoma multiforme: Pathophysiological and clinical aspects
- Gene therapy for chronic granulomatous disease: current status and future perspectives
- Muscle satellite cells and duchenne muscular dystrophy
- In vivo enrichment of cytidine deaminase gene-modified hematopoietic cells by prolonged cytosine-arabinoside application
- A Src family kinase–Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation
- Bmi1 confers resistance to oxidative stress on hematopoietic Stem cells
- The mechanistic links between proteasome activity, aging and agerelated diseases
- The role of histone methyltransferase EZH2 in myelodysplastic syndromes
- Skewed X-inactivation patterns in ageing healthy and myelodysplastic haematopoiesis determined by a pyrosequencing based transcriptional clonality assay
- Genetic and signaling pathway regulations of tumor-initiating cells of the prostate
- Triptolide inhibits histone methyltransferase EZH2 and modulates the expression of its target genes in prostate cancer cells
- Pin1: a molecular orchestrator in the heart
- Cdkn1b overexpression in adult mice alters the balance between genome and tissue ageing
- Dept. of Laboratory Medicine and Pathology Yale University School of Medicine 330 Cedar St., New Haven, CT 06520
- DNA damage accumulation and repair defects in acute myeloid leukemia: implications for pathogenesis, disease progression, and chemotherapy resistance
- Host–microbiota interaction and intestinal Stem cells in chronic inflammation and colorectal cancer
- Is going for cure in chronic myeloid leukemia possible and justifiable?
- Transcriptional regulation of haematopoietic Stem cells
- Mutations in the telomere capping complex in bone marrow failure and related syndromes
- Aging Kit mutant mice develop cardiomyopathy
- Advances in meniscal tissue engineering
- Aging and impaired hematopoiesis
- Stem Cells Propagate Their DNA by Random Segregation in the Flatworm
- Lower levels of circulating progenitor cells are associated with low physical function and performance in elderly men with impaired glucose tolerance: a pilot substudy …
- Alteration of cardiac progenitor cell potency in GRMD dogs
- Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis. an integral model
- Hutchinson-Gilford Progeria Syndrome: Pathophysiology and Possible Treatments
- M (o) TOR of pseudo-hypoxic state in aging: rapamycin to the rescue
- Identification and Characterization of Signaling Pathways Underlying the Tumorigenic Activity of ΔNp63α in Breast Cancer Stem Cells
- The Role of STRA13 in Hematopoiesis
- Answering the ultimate question “what is the proximal cause of aging?”
- Journal of Aging Science
- Ex vivo expansion of cord blood progenitors impairs their short‐term and long‐term repopulating activity associated with transcriptional dysregulation of signalling …
- Role of mesenchymal Stem cells (MSC) in HIV-1 associated bone and lipid toxicities
- Highlights of the mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology
- p16INK4a protects against dysfunctional telomere–induced ATR-dependent DNA damage responses
- TPP1 as a versatile player at the ends of chromosomes
- High fat diet rapidly suppresses B lymphopoiesis by disrupting the supportive capacity of the bone marrow niche
- Cord Blood Ex Vivo Expansion
- Myelofibrosis 2012: it’s complicated
- Fetal myocardium in the kidney capsule: An in vivo model of repopulation of myocytes by bone marrow cells
- Mesenchymal Stem cells for therapy in lung diseases
- Targeting the mTOR signaling network for Alzheimer’s disease therapy
- MOZ‐Mediated Repression of p16INK4a Is Critical for the Self‐Renewal of Neural and Hematopoietic Stem Cells
- MERIStem DISORGANIZATION1 Encodes TEN1, an Essential Telomere Protein That Modulates Telomerase Processivity in Arabidopsis
- Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a-and Arf-independent manner
- Understanding the process of fibrosis in Duchenne muscular dystrophy
- Depletion of Jak2V617F myeloproliferative neoplasm-propagating Stem cells by interferon-α in a murine model of polycythemia vera
- Development of approaches to improve the regenerative potential of muscle Stem cells
- cell and gene therapy for severe heart failure patients: the time and place for Pim-1 kinase
- The role of protein clearance mechanisms in organismal ageing and age-related diseases
- Muscular dystrophies share pathogenetic mechanisms with muscle sarcomas
- An Opposite Effect of the CDK Inhibitor, p18INK4c on Embryonic Stem Cells Compared with Tumor and Adult Stem Cells
- Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity
- B-lineage transcription factors and cooperating gene lesions required for leukemia development
- Functional Characterization of TPO‐Expanded CD34+ Cord Blood Cells Identifies CD34−CD61− Cells as Platelet‐Producing Cells Early After Transplantation in NOD/SCID …
- BAF60 A, B, and Cs of muscle determination and renewal
- TAP-deficient human iPS cell -derived myeloid cell lines as unlimited cell source for dendritic cell -like antigen-presenting cells
- Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD
- Murine Adipose Tissue-Derived Stromal cell Apoptosis and Susceptibility to Oxidative Stress In Vitro Are Regulated by Genetic Background
- P53-participated cellular and molecular responses to irradiation are cell differentiation-determined in murine intestinal epithelium
- Targeting myelogenous leukemia Stem cells: role of the circulation
- Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome …
- The ageing process and healthy ageing
- Organelle Stress and mTOR in Aging-Associated Inflammation
- The Role of UPF Proteins in Nonsense-Mediated Decay and in Neurogenesis
- Aged human cells rejuvenated by cytokine enhancement of biomaterials for surgical ventricular restoration
- Cheating death: does the new biology of aging show us the way?
- Expression of the runt homology domain of RUNX1 disrupts homeostasis of hematopoietic Stem cells and induces progression to myelodysplastic syndrome
- The hallmarks of fibroblast ageing
- Age dependence of lung mesenchymal stromal cell dynamics following pneumonectomy
- The role of the Rho/Rock signaling pathway in the pathogenesis of acute ischemic myocardial fibrosis in rat models
- Vascular-targeted therapies for Duchenne muscular dystrophy
- Blunt-ended telomeres: an alternative ending to the replication and end protection stories
- Idiopathic pulmonary fibrosis: diagnosis and prognostic evaluation
- Staying alive: metabolic adaptations to quiescence
- Lamins at a glance
- Cord blood transplantation: can we make it better?
- Accelerated aging among cancer survivors: from pediatrics to geriatrics
- The chromodomain helicase Chd4 is required for Polycomb‐mediated inhibition of astroglial differentiation
- The Evi5 family in cellular physiology and pathology
- MicroRNA expression altered by diet: can food be medicinal?
- Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
- Human umbilical cord mesenchymal Stem cells are induced in vitro to differentiate into fibroblasts
- The roles of retinoic acid and retinoic acid receptors in inducing epigenetic changes
- Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR)
- Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophin
- Nestin expression in end-stage disease in dystrophin-deficient heart: implications for regeneration from endogenous cardiac Stem cells
- Chromatin remodeling, DNA damage repair and aging
- A nutrient-sensitive restriction point is active during retinal progenitor cell differentiation
- Telomerase is required for zebrafish lifespan
- Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells
- Monitoring the response to tyrosine kinase inhibitor (TKI) treatment in chronic myeloid leukemia (CML)
- Cellular immunotherapy strategies for Ewing sarcoma
- mTOR pathway in colorectal cancer: an update
- Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
- Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of dyskeratosis congenita
- A three-state model of telomere control over human proliferative boundaries
- Life in the fast lane: mammalian disease models in the genomics era
- Telomere loss in Philadelphia-negative hematopoiesis after successful treatment of chronic myeloid leukemia: evidence for premature aging of the myeloid …
- Dysregulated hematopoiesis caused by mammary cancer is associated with epigenetic changes and hox gene expression in hematopoietic cells
- Senescence regulation by mTOR
- Self-renewal and differentiation of muscle satellite cells are regulated by the Fas-associated death domain
- Stem Cells in Dystrophic Animal Models: From Preclinical to Clinical Studies
- Recent progress toward epigenetic therapies: the example of mixed lineage leukemia
- Physiologic hypoxia promotes maintenance of CML Stem cells despite effective BCR-ABL1 inhibition
- MicroRNA 146 (Mir146) Modulates Spermatogonial Differentiation by Retinoic Acid in Mice
- Epigenetic role of miRNAs in normal and leukemic hematopoiesis
- Simultaneous shoulder and hip dislocation in a 12-year-old girl with Hutchinson-Gilford progeria syndrome
- FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors
- Epigenomics of idiopathic pulmonary fibrosis
- Asymmetric Division of Damaged Proteins in Proliferating Cells
- Familial partial lipodystrophy, mandibuloacral dysplasia and restrictive dermopathy feature barrier-to-autointegration factor (BAF) nuclear redistribution
- Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2
- Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy
- Iron chelation therapy in myelodysplastic syndromes: where do we stand?
- JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia
- The Identification and Characterization of Stem/Progenitor Cells in the Ovarian Surface Epithelium
- Pim1 serine/threonine kinase regulates the number and functions of murine hematopoietic Stem cells
- Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI’s provocative questions
- Pharmacological treatment of idiopathic pulmonary fibrosis: from the past to the future
- Nuclear matrix, nuclear envelope and premature aging syndromes in a translational research perspective
- Histone methylation and aging: lessons learned from model syStems
- The LKB1 tumor suppressor controls spindle orientation and localization of activated AMPK in mitotic epithelial cells
- Cellular and molecular longevity pathways: the old and the new
- The Wnt/β-catenin signaling circuitry in head and neck cancer
- MTG16, a target of the t (16; 21), contributes to murine lymphoid development
- Ex vivo molecular rejuvenation improves the therapeutic activity of senescent human cardiac Stem cells in a mouse model of myocardial infarction
- Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy
- The role of chromatin modifiers in normal and malignant hematopoiesis
- Gene replacement therapies for duchenne muscular dystrophy using adeno-associated viral vectors
- Histone deacetylase inhibitors: a potential epigenetic treatment for Duchenne muscular dystrophy
- Genetic and epigenetic control of early lymphocyte development
- Cockayne syndrome b maintains neural precursor function
- Epigenetic and genetic mechanisms in red cell biology
- The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells
- Target gene regulation by PLZF in mouse undifferentiated spermatogonia
- Directing Skeletal Muscle Progenitor cell Fate from Human Pluripotent Stem Cells
- CST for the grand finale of telomere replication
- Role of microRNAs in the age-related changes in skeletal muscle and diet or exercise interventions to promote healthy aging in humans
- PKC theta ablation improves healing in a mouse model of muscular dystrophy
- Maintenance and expansion of hematopoietic Stem cells in vitro using genetic methods
- mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases
- The effect of the Ras homolog gene family (Rho), member A/Rho associated coiled‑coil forming protein kinase pathway in atrial fibrosis of type 2 diabetes in …
- Myofiber branching rather than myofiber hyperplasia contributes to muscle hypertrophy in mdx mice
- An Expanding Role for Nuclear Factor κB in Muscle Stem Cells: Implications for the Treatment of Duchenne Muscular Dystrophy
- Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling
- Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat
- Delineating molecular mechanisms of squamous tissue homeostasis and neoplasia: focus on p63
- Recent developments in the treatment of Duchenne muscular dystrophy and spinal muscular atrophy
- Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B
- Hip pathology in Hutchinson–Gilford progeria syndrome: a report of two children
- Infantile Alopecia, Characteristic Facies and Sclerosed Atrophic Limbs
- Noninvasive in vivo assessment of muscle impairment in the mdx mouse model–a comparison of two common wire hanging methods with two different results
- Dystrophic Changes in Extraocular Muscles after Gamma Irradiation in mdx:utrophin+/− Mice
- Current management of chronic myeloid leukemia with tyrosine kinase inhibitors
- Telomeres: their structure and maintenance
- Hyaluronan in the healthy and malignant hematopoietic microenvironment
- Pten loss in the bone marrow leads to G-CSF–mediated HSC mobilization
- Single cell analyses of regulatory network perturbations using enhancer targeting TAL Effectors suggest novel roles for PU. 1 during haematopoietic specification
- Microglial dysfunction in brain aging and Alzheimer’s disease
- Wnt/β-catenin pathway in bone cancers
- RUNX1 meets MLL: epigenetic regulation of hematopoiesis by two leukemia genes
- Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer
- Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells
- Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling …
- Ageing and the border between health and disease
- Cellular polarity in aging: role of redox regulation and nutrition
- Exploiting tumor cell senescence in anticancer therapy
- NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas
- Bone tissue and muscle dystrophin deficiency in mdx mice
- Plasticity of salamander skeletal muscle cells
- Satellite cell senescence underlies myopathy in a mouse model of limb-girdle muscular dystrophy 2H
- Grafting of a single donor myofibre promotes hypertrophy in dystrophic mouse muscle
- Telomeropathies: An emerging spectrum disorder
- Defining the mechanism of prostaglandin E2- Enhanced hematopoietic Stem and progenitor cell homing
- Selected clinical highlights from the 2012 ERS congress in Vienna
- Epigenomic programing: a future way to health?
- Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy
- The role of epigenetic modifiers in hematopoiesis
- Human CST abundance determines recovery from diverse forms of DNA damage and replication stress
- Aplastic anaemia: pathophysiology, care and management
- The lilliputians and the giant: an emerging oncogenic microRNA network that suppresses the PTEN tumor suppressor in vivo
- Graft-versus-host disease causes broad suppression of hematopoietic 2 primitive cells and block in megakaryocyte differentiation in a murine 3 model 4
- The emerging roles of AhR in physiology and immunity
- The c-Jun N-terminal Kinases (JNK)/Mitogen-activated Protein Kinase (MAPK) is Responsible for the Protection of Tanshinol (Danshensu) upon H 2 O 2 …
- Ubiquitination and the Ubiquitin–Proteasome SyStem as regulators of transcription and transcription factorsin epithelial mesenchymal transition of cancer
- A review of current and novel therapies for idiopathic pulmonary fibrosis
- Understanding nucleotide excision repair and its roles in cancer and ageing
- Ontology of Aging
- Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy
- SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
- Regulation of neural precursor self-renewal via E2F3-dependent transcriptional control of EZH2
- Conversations with pioneers in the bone field: Stavros C Manolagas
- Premature aging syndrome
- Geriatric population and relevant contemplation
- Notch1 regulates progenitor cell proliferation and differentiation during mouse yolk sac hematopoiesis
- High Fat Diet Rapidly Suppresses B Lymphopoiesis by Disrupting the Supportive Capacity of
- CT-0507 Accepted 10/21/2011 for publication in “cell Transplantation” Alteration of cardiac progenitor cell potency in GRMD dogs
- Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions
- Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL
- Insights into skeletal muscle development and applications in regenerative medicine
- Idiopathische pulmonale Fibrose: Diagnostik und prognostische Beurteilung
- Mammalian target of rapamycin signaling in cardiac physiology and disease
- Enhancer of zeste homolog 2 is a negative regulator of mitochondria-mediated innate immune responses
- Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification
- Pharmacologic Profiling of Phosphoinositide 3-Kinase Inhibitors as Mitigators of Ionizing Radiation–Induced cell Death
- Pirfenidone for the treatment of idiopathic pulmonary fibrosis
- l-Leucine Alters Pancreatic β-cell Differentiation and Function via the mTor Signaling Pathway
- The human CST complex is a terminator of telomerase activity
- Cdk1 regulates the temporal recruitment of telomerase and Cdc13-Stn1-Ten1 complex for telomere replication
- The biology of telomeres in multipotential stromal cells
- Current status of idiopathic nonspecific interstitial pneumonia
- Calorie restriction and NAD+/sirtuin counteract the hallmarks of aging
- Aging of the brain, dementias, role of infectious proteins: facts and theories
- The histone methyltransferase Ezh2 is a crucial epigenetic regulator of allogeneic T-cell responses mediating graft-versus-host disease
- Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma
- Inflammation in Muscle Repair, Aging, and Myopathies
- Genetically engineered mouse models of human B-cell precursor leukemias
- Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle
- Role of oxidative stress and telomerase on haematopoietic Stem and progenitor cell ageing
- Loss of telomere protection: consequences and opportunities
- Molecular basis of telomere syndrome caused by CTC1 mutations
- Pathogenesis of idiopathic pulmonary fibrosis and its clinical implications
- Defective repair of oxidative base lesions by the DNA glycosylase Nth1 associates with multiple telomere defects
- Intermittent Hypoxia and Health: From Evolutionary Aspects to Mitochondria Rejuvenation
- Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in
- Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities
- The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability
- RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells
- Alive and well? Exploring disease by studying lifespan
- Anti-aging effects of Ketanserin; Ketanserin extends lifespan in female drosophila, inhibits cellular senescence and promotes wound healing in-vitro
- A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis
- Identifying and validating a combined mRNA and microRNA signature in response to imatinib treatment in a chronic myeloid leukemia cell line
- Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs
- Regenerative strategies for craniofacial disorders
- Analysis of Poly(ADP-Ribose) Polymerases in Arabidopsis Telomere Biology
- Transcriptional and Epigenetic Regulation in the Development of Myeloid Cells: Normal and Diseased Myelopoiesis
- Murine models of dysfunctional telomeres and telomerase
- Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders
- Mammalian target of rapamycin and the kidney. I. The signaling pathway
- Emerging drugs for polycythemia vera
- The Role of the E47-p21 Pathway in Long-Term Hematopoietic Stem Cells During Homeostasis and Under Repopulation Stress
- Exacerbation of lung radiation injury by viral infection: the role of Clara cells and Clara cell secretory protein
- Distinct transforming activity of ABL family tyrosine kinase oncogenes is induced by their C-terminal domain
- Cdc13 at a crossroads of telomerase action
- MURINE DYSFUNCTIONAL MODELS OF TELOMERES AND TELOMERASE
- NCI’s provocative questions on cancer: some answers to ignite
- In vivo behaviour of human precursors into a dystrophic context
- POT1a and Components of CST Engage Telomerase and Regulate Its Activity in Arabidopsis
- Detection and quantification of extracellular microRNAs in murine biofluids
- Animal models of duchenne muscular dystrophy, with special reference to the mdx mouse
- Cutting through the complexities of mTOR for the treatment of stroke
- CTC1 increases the radioresistance of human melanoma cells by inhibiting telomere shortening and apoptosis
- Potential therapeutic approaches for modulating expression and accumulation of defective lamin A in laminopathies and age-related diseases
- Targeting the cell Cycle for Cancer Treatment and Neuroprotection
- Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging
- WNT7B promotes bone formation in part through mTORC1
- BioMed Research International
- Smoking accelerates aging of the small airway epithelium
- SOX2 is critical for the maintenance of quiescence and homeostasis in nascent Müller glial cells
- Network medicine, multimorbidity and the lung in the elderly
- 20 CHAPTER Childhood Muscular Dystrophies
- THE ROLE OF WNTS IN ADULT MURINE HEMATOPOIESIS AND INTESTINAL HOMEOSTASIS
- The CDK network: linking cycles of cell division and gene expression
- New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses
- TUMOR BURDEN INDUCES A SELF-AMPLIFYING LOOP OF MYELOPOIESIS
- RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement
- Cellular Senescence and Premature Aging in Lung Diseases
- Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers
- Intermittent Hypoxia and Health: From Evolutionary Aspects
- Organization and evolution of Drosophila terminin: similarities and differences between Drosophila and human telomeres
- Runx Family Genes in a Cartilaginous Fish, the Elephant Shark (Callorhinchus milii)
- DNA repair at telomeres: keeping the ends intact
- Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting
- Replication of telomeres and the regulation of telomerase
- The aryl hydrocarbon receptor nuclear translocator (ARNT) modulates the antioxidant response in AML cells
- The Detection of Progerin Expression in Mammals
- Identification of Novel HIF1A Target Genes That Regulate Tumor Progression and Metastasis
- Importance of epigenetic changes in cancer etiology, pathogenesis, clinical profiling, and treatment: what can be learned from hematologic malignancies?
- Congenital vulnerability of cutaneous segments arising from skin mosaicism: A genetic basis for locus minoris resistentiae
- Comparative genomics of X-linked muscular dystrophies: the golden retriever model
- Current Issues in Chronic Myeloid Leukemia: Monitoring, Resistance, and Functional Cure
- Regulation of the hematopoietic self-renewal and lineage choice: role of Pbx1 and micro-RNAs
- Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer
- Impaired viability of muscle precursor cells in muscular dystrophy with glycosylation defects and amelioration of its severe phenotype by limited gene expression
- A Surrogate mRNA-Based Single cell Assay for Rapidly Enumerating Rare Long-Term Hematopoietic Stem Cells
- Sexual dimorphism in the early embryogenesis in zebra finches
- T cells development in vitro: a minimalist approach
- Growth phase-dependent roles of Sir2 in oxidative stress resistance and chronological lifespan in yeast
- Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and …
- Immunopathogenesis of Primary Cicatricial Alopecia
- The THO complex component Thp2 counteracts telomeric R‐loops and telomere shortening
- HOT1 is a mammalian direct telomere repeat‐binding protein contributing to telomerase recruitment
- Anti-aging effects of the Transcendental Meditation Program: Analysis of ojas level and global gene expression
- A Highlights from MBoC Selection: Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle
- Assessment of cardiac function in three mouse dystrophinopathies by magnetic resonance imaging
- Characterization of RUNX1 function in hematopoiesis
- Human CST has independent functions during telomere duplex replication and C-strand fill-in
- TGF-β signaling in Duchenne muscular dystrophy
- The GH/IGF-1 axis in ageing and longevity
- A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression
- A Novel Response to Cellular Hypoxia Increases Lifespan in C. elegans
- Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres
- Beyond telomerase: Telomere instability as a novel target for cancer therapy
- Role of STN1 and DNA polymerase α in telomere stability and genome-wide replication in Arabidopsis
- DNA Damage Response and Replication Stress in Mouse Embryonic Stem Cells
- NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies
- Myc-mediated transcription control of SAE1 and PUMA loci in cancer and reprogramming
- Characterization and rescue of telomeric abnormalities in ICF syndrome type I fibroblasts
- Mammalian DNA2 helicase/nuclease cleaves G‐quadruplex DNA and is required for telomere integrity
- Hematopoietic syStem
- EXPLOITING VASOPRESSIN SIGNALLING IN MUSCULAR ATROPHY AND DYSTROPHIES
- Hutchison-Gilford Progeria Syndrome–A new treatment strategy and the role of prelamin A in oncogenesis
- Regulation of DNA damage responses by ubiquitin and SUMO
- mTOR signaling in cardiac physiology and disease: Sciarretta et al. mTOR signaling in the cardiovascular syStem
- Non-coding RNAs in cardiovascular ageing
- The size–life span trade-off decomposed: why large dogs die young
- Idiopathic Pulmonary Fibrosis: Treatment Strategies
- MMP-7 and fcDNA serum levels in early NSCLC and idiopathic interstitial pneumonia: preliminary study
- Structure of the human telomeric Stn1-Ten1 capping complex
- Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity
- The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch
- Role of Setbp1 in Myeloid Leukemia Development
- Telomere-end processing: mechanisms and regulation
- CDK1 differentially regulates G-overhang generation at leading- and lagging-strand telomeres in telomerase-negative cells in G2 phase
- General Transcription Factors and Embryonic Genome Activation
- Persistent GATA2 expression promotes self-renewal of myeloid progenitors and blocks lymphoid differentiation
- Functional Analysis of ACD Mutations in Dyskeratosis Congenita.
- Characterization of the Runx Gene Family in a Jawless Vertebrate, the Japanese Lamprey (Lethenteron japonicum)
- DNA Damage Response and Replication Stress in Mouse Embryonic Stem Cells
- Role of the neurotrophic factor receptor RET in haematopoiesis
- From signal transduction to targeted therapy: interference with TGF-β and myostatin signaling for Duchenne muscular dystrophy Date: 2012-10-16
- Double bromodomain proteins as regulators of lymphopoiesis and inflammation
- From signal transduction to targeted therapy: interference with TGF-_ and myostatin signaling for Duchenne muscular dystrophy
- Clinical highlights from the 2011 ERS Congress in Amsterdam
- Structural and functional association of androgen receptor with telomeres in prostate cancer cells
- Impact of Gestational Exposure to 2, 3, 7, 8-Tetrachlorodibenzo-P-Dioxin on T Lymphocyte Development
- Comparação do potencial terapêutico de células mesenquimais e pericitos em modelo murino de distrofia muscular
- Effects of Heregulin on Muscle: A Biochemical and Histological Analysis
- A paper in print at the Journal of the Federation of American Societies for Experimental Biology3
- Pathways Disturbed in Duchenne Muscular Dystrophy
- Contribution of the GATA2 transcription factor to the development and progression of myeloid disorders
- Idiopathic pulmonary fibrosis may be a disease of recurrent, tractional injury to the periphery of the aging lung: a unifying hypothesis regarding etiology and …
- Isolation of primary canine satellite cells
- Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and …
- A chromatin-modifying protein is a context-dependent modulator of cell survival in hematopoietic malignancies
- ESGCT and NVGCT Collaborative Congress: The Hague-23 to 26 October Abstracts
- Artemis C-terminal region facilitates V (D) J recombination through its interactions with DNA Ligase IV and DNA-PKcs
- The dynamic behavior and cellular evolution of multilineage leukemias induced by the Polycomb group protein Cbx7
- MicroRNAs expression profiles in cardiovascular diseases
- Lipid replacement therapy: a natural medicine approach to replacing damaged lipids in cellular membranes and organelles and restoring function
- A Comparative Study of N-glycolylneuraminic Acid (Neu5Gc) and Cytotoxic T cell (CT) Carbohydrate Expression in Normal and Dystrophin-Deficient Dog …
- The effects of mammary tumours on hematopoiesis and dendritic cell development
- The impact of MAO-A in cellular senescence
- The genetic pleiotropy of musculoskeletal aging
- If the cap fits, wear it: an overview of telomeric structures over evolution
- The Role of microRNA miR-101 in Prostate Cancer Progression
- Aryl hydrocarbon receptor (AhR) attenuation of subchronic cigarette smoke-induced pulmonary neutrophilia is associated with retention of nuclear RelB and …
- Characterization of the putative CALM/AF10 collaborator Meis1 in leukemia development
- A mouse model for dominant collagen VI disorders: heterozygous deletion of Col6a3 Exon 16
- Regulation of early B cell development by Flt3 signaling
- Dissecting the epigenetic landscapes of hematopoiesis and fission yeast.
- Pbx1-directed transcriptional regulation of mural cell differentiation and vascular patterning in the developing kidney and spleen
- Why Do Vaccines Fail the Elderly?
- Consequences of endogenous mitochondrial oxidative stress in the heart
- Genome-Wide Loss-of-Function Genetic Screens Identify Novel Senescence Genes and Putative Tumor Suppressors
- Chemical genetic analyses of quantitative changes in Cdk1 activity during the human cell cycle
- A mechanistic examination of the inhibitory role of cyclic AMP signaling on megakaryocytic differentiation
- Regulation of the Ran GTPase SyStem and Nucleocytoplasmic Transport
- Mediators and markers of mammalian lifespan extension: Proteomic, proliferative and hormonal adaptations in mouse models of extended lifespan
- A Comparative Study of N-glycolylneuraminic Acid (Neu5Gc) and
- Dissection of the telomere complex CST in Arabidopsis thaliana
- Evaluating the PGC-1 alpha pathway and a new preclinical model to advance treatment options for dystrophinopathies
- The Rho-GAP GRAF1 Regulates Skeletal Muscle Maturation and Repair
- Defining the Sequence Elements and Candidate Genes for the Coloboma Mutation
- NEUROTROPHIN RECEPTOR P75NTR AND ITS LIGAND BDNF IN HUMAN SKELETAL MUSCLE: INVOLVEMENT IN MYOGENESIS AND MUSCLE REPAIR
- Dose-thresholds for alpha-radiation induced cancer risk: absence of risk following small alpha-emitting radionuclide intakes
- THE INTERPLAY BETWEEN RUNX3 AND TEAD-YAP COMPLEX IN GASTRIC CANCER
- CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point
- Endothelial progenitor cells as biomarkers for cardiovascular risk
- REACTIVE OXYGEN SPECIES AND TELOMERE DYSFUNCTION: INVESTIGATING THE UNDERLYING MECHANISMS OF AGING AND RELATED DISEASES
- Identification and characterization of senescence-associated microRNAs in a mouse model of the XFE progeroid syndrome
- Telomere stability and development of ctc1 mutants are rescued by inhibition of EJ recombination pathways in a telomerase-dependent manner
- Discussion of “Biomedical Infor-matics: We Are What We Publish”
- Novel mechanisms of transcriptional regulation by leukemia fusion proteins
- The metabolic syndrome and HIV infection
- On the Phenotype of White-tailed Deer Antlerogenic Progenitor Cells.
- Isolation and characterization of human endothelial colony forming cells (ECFCs) and effect of oxidative stress on their differentiation
- Telomere and proximal sequence analysis using high-throughput sequencing reads
- Relationship of individual pilot factors to simulated flight performance
- Alternative splicing by hnRNP L as a new regulator of hematopoietic cell development, survival and migration
- NLRC3 is a negative regulator of DNA-induced immune response
- Discussion of “Biomedical informatics: We are what we publish”
- Structural and Functional Analysis of mTORB
- Measurement of Bone Translations and Sarcomere Lengths in Humans Using Novel Optical SyStems
- TYPE IInterferons IN SYStemIC LUPUS ERYTHEMATOSUS
- Differential functions of mammalian Cdk7 and CCRK kinases in regulating transcription and ciliogenesis
- Structural, functional and genomic changes associated to aging in the liver of rats fed life-long on virgin olive, sunflower or fish oils, as dietary fats
- Regulation of eukaryotic transcription by bHLH/PAS transcription factors AhR and Arnt.
- Circadian regulation of mTOR signaling via BMAL1 dependent mechanism
- Theories and mechanisms of aging
- Cyclin D: Cdk4/6 Complexes Activate Rb by Mono-Phosphorylation
- Small Molecule Modulators of Dauer Formation and Longevity in Caenorhabditis Elegans
- Direct Assessment of Respiratory and Cardiac Function and Reserve Capacity in a Large Animal Model of Duchenne Muscular Dystrophy.
- Age-related effects on the mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in breast cancer and the characterization of novel MEK5 …
- Control of the G1/S Transition of the cell Cycle by the CDK Activating Kinase, Cdk7
- A co-translational ubiquitination pathway for quality control of newly synthesized proteins
- The role of the polyadenylation site of the melanocortin 1 receptor in generating MC1R-TUBB3 chimeras, And, Attenuation of TORC1 delays the onset of …
- Sepsis induces hematopoietic Stem cell exhaustion and myelosuppression through distinct contributions of TRIF and MYD88
- CXCR4/CXCL12 axis counteracts hematopoietic Stem cell exhaustion through selective protection against oxidative stress
- Metabolism and the control of cell fate decisions and Stem cell renewal
- Hematopoietic Stem cell exhaustion and advanced glycation end-products in the unexplained anemia of the elderly
- Stem cells and aging
- … of Ptch2 Activates Canonical and Non-Canonical HH Signaling within the Niche Leading to Myeloproliferation, Stem cell exhaustion and Accelerates JAK2V617F …
- Oxymetholone therapy of fanconi anemia suppresses osteopontin transcription and induces hematopoietic Stem cell cycling
- Rejuvenating muscle Stem cell function: restoring quiescence and overcoming senescence
- Stem cell depletion by global disorganization of the H3K9me3 epigenetic marker in aging
- Chronic Infection Drives Hematopoietic Stem cell exhaustion through Differentiation and a Lowered Threshold for Apoptosis
- … : Mesenchymal Stem Cells From Idiopathic Pulmonary Fibrosis Patients Display Signs Of Senescence Leading To Stem cell exhaustion That May Result In Lower …
- Inactivation of a Gαs–PKA tumour suppressor pathway in skin Stem cells initiates basal-cell carcinogenesis
- Chemotherapy and Stem cell transplantation increase p16INK4a expression, a biomarker of T-cell aging
- Neural Stem cells and nutrients: poised between quiescence and exhaustion
- From “traction bronchiectasis” to honeycombing in idiopathic pulmonary fibrosis: a spectrum of bronchiolar remodeling also in radiology?
- Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal Stem cells
- Novel chemical attempts at ex vivo hematopoietic Stem cell expansion
- Defining the general principles of Stem cell aging: lessons from organismal models
- Cbfb deficiency results in differentiation blocks and Stem/progenitor cell expansion in hematopoiesis
- Dok1 and Dok2 proteins regulate cell cycle in hematopoietic Stem and progenitor cells
- Stem cell maintenance: aMPLe splicing choices
- Metabolic regulation of Stem cell function in tissue homeostasis and organismal ageing
- The ubiquitin ligase HUWE1 regulates hematopoietic Stem cell maintenance and lymphoid commitment
- Decoding the RNA Editome of Normal Versus Malignant Progenitor cell Aging Short Title: RNA Editing in Normal Aging and MDS/AML Stem Cells
- RNA processing signatures of normal versus malignant progenitor cell aging predict leukemia Stem cell sensitivity to RNA splicing modulation
- Accelerated ageing of the lung in COPD: new concepts
- An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic Stem cell fate
- Molecular mechanisms of normal and pathological aging
- The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic Stem cells
- Fancb deficiency impairs hematopoietic Stem cell function
- Ultraviolet radiation-induced skin aging: the role of DNA damage and oxidative stress in epidermal Stem cell damage mediated skin aging
- Preclinical Study for the Use of Abatacept to Prevent Rejection of Allogeneic CD34+ Cells in a Xenograft Model
- Stem cell aging and sex: are we missing something?
- The PCL1-p53 axis promotes cellular quiescence
- WNT signaling in lung aging and disease
- Declined presentation PRMT5 methyltransferase activity is required to sustain adult hematopoiesis
- The syStemic milieu as a mediator of dietary influence on Stem cell function during ageing
- Telomere dysfunction causes alveolar Stem cell failure
- Wnt signalling meets epigenetics
- Aneuploidy impairs hematopoietic Stem cell fitness and is selected against in regenerating tissues in vivo
- The aging population: demographics and the biology of aging
- Pilot Study of Prognostic Impact of Pre-Allogeneic Hematopoietic cell Transplantation (HCT) Plasma Levels of CXC-Chemokines (CXCL-4 and CXCL-7) in …
- Targeting muscle Stem cell intrinsic defects to treat Duchenne muscular dystrophy
- Neuropeptide Y: an anti-aging player?
- Adult muscle Stem cell isolation
- Aging and pulmonary fibrosis
- Stem cell mitochondria during aging
- Aging and kidney disease.
- Optimization of reference genes for normalization of reverse transcription quantitative real-time polymerase chain reaction results in senescence study of …
- Stem cell therapy for intervertebral disc regeneration: obstacles and solutions
- Chemotherapy and Stem cell Transplantation Increase p16INK4a Expression, a Biomarker of T-cell Aging
- Metabolic regulation of hematopoietic Stem cell commitment and erythroid differentiation
- Increased gene dosage of Ink4/Arf and p53 delays age‐associated central nervous syStem functional decline
- TCDD-induced activation of aryl hydrocarbon receptor regulates the skin Stem cell population
- When Stem cells grow old: phenotypes and mechanisms of Stem cell aging
- Aryl hydrocarbon receptor deficiency in an exon 3 deletion mouse model promotes hematopoietic Stem cell proliferation and impacts endosteal niche cells
- Identifying Micrornas that Regulate Aging of the Germline Stem cell Niche
- Mechanisms of development of multimorbidity in the elderly
- Epigenetic control of adult Stem cell function
- Deubiquitinase MYSM1 is essential for normal bone formation and mesenchymal Stem cell differentiation
- Regulation of skeletal muscle Stem cell quiescence by Suv4-20h1-dependent facultative heterochromatin formation
- miR‐152 induces human dental pulp Stem cell senescence by inhibiting SIRT 7 expression
- The role of mitochondrial dysfunction in age-related diseases
- Hutchinson–Gilford progeria syndrome as a model for vascular aging
- iPSCs-based anti-aging therapies: Recent discoveries and future challenges
- 282. Circumventing Hematopoietic Toxicities and Reversing Sickle Phenotype by Lineage-Specific BCL11A Knock Down and γ-Globin Induction
- G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy
- Progeria accelerates adult Stem cell aging
- 283. In Vivo Selection of MGMT (P140K) Gene Modified Hematopoietic Cells in the Nonhuman Primate Unmasks a Dormant Pool of Repopulating Clones with …
- Molecular and biological hallmarks of ageing
- As “SIRT” ing the role of an epigenetic modifier in hematopoietic Stem cell homeostasis
- A rat treated with mesenchymal Stem cells lives to 44 months of age
- Loss of Folliculin Disrupts Hematopoietic Stem cell Quiescence and Homeostasis Resulting in Bone Marrow Failure
- Natural (tryptophan) metabolites—mediated activation of aryl hydrocarbon receptor inhibits cancer Stem cell signaling: what does it mean to prevent cancer …
- DDIT4 regulates mesenchymal Stem cell fate by mediating between HIF1α and mTOR signalling
- Leukemic Stem Cells S (p) liced Off
- Molecular regulation of muscle Stem cell asymmetric division
- NucleoStemin rejuvenates cardiac progenitor cells and antagonizes myocardial aging
- SOX17 is critical for the maintenance of Stem cell phenotype of intra-aortic hematopoietic clusters of cells in the aorta-gonad-mesonephros region
- Innate immune signaling and Stem cell renewal in idiopathic pulmonary fibrosis
- Suppression of Luteinizing Hormone Enhances HSC Recovery after Hematopoietic Injuries
- Abstract PR06: Mutant U2AF1 alters hematopoiesis and pre-mRNA splicing in transgenic mice.
- The APC/C Coactivator Cdh1 Controls Self-Renewal and Differentiation of Human and Murine HSPCs
- The central role of muscle Stem cells in regenerative failure with aging
- Tissue-specific designs of Stem cell hierarchies
- Determinants of frailty and longevity: are they the same ones?
- Regenerative medicine in the treatment of idiopathic pulmonary fibrosis: current position
- Autophagy: a decisive process for Stemness
- Genome integrity in aging: human syndromes, mouse models, and therapeutic options
- High levels of canonical Wnt signaling lead to loss of Stemness and increased differentiation in hematopoietic Stem cells
- Rationale and design of the allogeneiC human mesenchymal Stem cells (hMSC) in patients with aging fRAilTy via intravenoUS delivery (CRATUS) study: A …
- Decoding the Stem cell quiescence cycle–lessons from yeast for regenerative biology
- cell cycle regulation of hematopoietic Stem or progenitor cells
- Epigenetic control of Stem cell potential during homeostasis, aging, and disease
- Unmanipulated haploidentical haematopoietic Stem cell transplantation for children with severe aplastic anaemia
- Role of lncRNAs in cellular aging
- cell hierarchies in colorectal cancer: focus on APC and BRAF
- Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic Stem cell ex vivo expansion
- Adult thymic epithelial cell (TEC) progenitors and TEC Stem cells: Models and mechanisms for TEC development and maintenance
- Brief report: the differential roles of mTORC1 and mTORC2 in mesenchymal Stem cell differentiation
- The basic principles of Stem cells
- Quantitative analysis of male germline Stem cell differentiation reveals a role for the p53-mTORC1 pathway in spermatogonial maintenance
- Polycomb repressive complex 2 component Suz12 is required for hematopoietic Stem cell function and lymphopoiesis
- Evidence that hematopoietic Stem cell function is preserved during aging in long-lived S6K1 mutant mice
- Hallmarks of the ageing lung
- Deciphering Metabolic Regulation of Hematopoietic Stem cell Fate
- Mechanism of Functional Alterations in Hematopoietic Stem cell Aging
- ICRP publication 131: Stem cell biology with respect to carcinogenesis aspects of radiological protection
- Insulin-like growth factor 2 modulates murine hematopoietic Stem cell maintenance through upregulation of p57
- MLL-AF9–and HOXA9-mediated acute myeloid leukemia Stem cell self-renewal requires JMJD1C
- Autophagy maintains Stemness by preventing senescence
- Effects of senescent lens epithelial cells on the severity of age-related cortical cataract in humans: A case–control study
- Role of Stem cell Therapy in Treatment of Muscular Dystrophy
- Potential links between tendon pathology and platelet rich plasma biology
- The Role of Stem cell Genomic Instability in Aging
- SIRT6 safeguards human mesenchymal Stem cells from oxidative stress by coactivating NRF2
- Olive oil and the hallmarks of aging
- A muscle Stem cell for every muscle: variability of satellite cell biology among different muscle groups
- Naive T cell maintenance and function in human aging
- Epigenetic control of adult skeletal muscle Stem cell functions
- Therapeutic potential of mTOR inhibitors for targeting cancer Stem cells
- Non‐steady‐state hematopoiesis regulated by the C/EBP β transcription factor
- Prmt5 is a regulator of muscle Stem cell expansion in adult mice
- Autonomous extracellular matrix remodeling controls a progressive adaptation in muscle Stem cell regenerative capacity during development
- Persistent Elevation of Plasma Thrombopoietin Levels in Severe Aplastic Anemia, Even with Hematologic Recovery
- Targeting the Stem cell niche with regenerative biomaterials
- Concise review: asymmetric cell divisions in Stem cell biology
- LECT2 drives haematopoietic Stem cell expansion and mobilization via regulating the macrophages and osteolineage cells
- Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic Stem cells in aged C57BL/6 J mice
- Jonathan A. Brassard, Natalie Fekete
- Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age
- Stem cell toxicology: a powerful tool to assess pollution effects on human health
- Neuropeptide Y regulates the hematopoietic Stem cell microenvironment and prevents nerve injury in the bone marrow
- Autophagy and Metabolism
- Biology of healthy aging and longevity
- Limbal Stem cell Transplantation for Soft Contact Lens Wear–Related Limbal Stem cell Deficiency
- Genome surveillance in pluripotent Stem cells: Low apoptosis threshold and efficient antioxidant defense
- Satellite cells in muscular dystrophy–lost in polarity
- Genome instability of ageing Stem cells—induction and defence mechanisms
- Stromal cells in phyllodes tumors of the breast are enriched for EZH2 and Stem cell marker expression
- Chromatin remodeling factor BRM is essential for the maintenance of HSC quiescence
- Molecular Mechanisms of Muscle Stem cell Aging
- Effects of poor maternal nutrition during gestation on bone development and mesenchymal Stem cell activity in offspring
- mTOR signaling promotes Stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration
- Asymmetric apportioning of aged mitochondria between daughter cells is required for Stemness
- Ageing induced vascular smooth muscle cell senescence in atherosclerosis
- Anti-Aging Effect of Siraitia grosuenorii by Enhancement of Hematopoietic Stem cell Function
- Microenvironmental regulation of hematopoietic Stem cells and its implications in leukemogenesis
- The master switchers in the aging of cardiovascular syStem, reverse senescence by microRNA signatures; as highly conserved molecules
- Deficiency in aryl hydrocarbon receptor (AHR) expression throughout aging alters gene expression profiles in murine long-term hematopoietic Stem cells
- Inflammation as a driver of clonal evolution in myeloproliferative neoplasm
- Stem cell and idiopathic pulmonary fibrosis: mechanisms and treatment
- Stem cell guidance through the mechanistic target of rapamycin
- Generation of Mouse Pluripotent Stem cell –Derived Proliferating Myeloid Cells as an Unlimited Source of Functional Antigen-Presenting Cells
- Dynamics And Aging Of Hematopoietic Stem Cells
- p38 mitogen-activated protein kinase inhibition enhances in vitro erythropoiesis of Fanconi anemia, complementation group A–deficient bone marrow cells
- GRK6 regulates ROS response and maintains hematopoietic Stem cell self-renewal
- Gene delivery for treating neurological disorders
- Signaling pathways and modifiers in cardiac function in muscular dystrophy
- A pre-clinical model of LGMD1D/DNAJB6 associated muscle disease: Expanding the role of HSP chaperones in skeletal muscle
- Aging, clonality, and rejuvenation of hematopoietic Stem cells
- Huajia Zhang, Sonia Rodriguez, 2 Lin Wang, 2 Soujuan Wang, 3 Henrique Serezani, 3 Reuben Kapur, 2
- Epigenetic perturbations in aging Stem cells
- Small-molecule inhibitors targeting INK4 protein p18INK4C enhance ex vivo expansion of haematopoietic Stem cells
- The hair follicle Stem cell niche: the bulge and its environment
- CD8+ T cells drive autoimmune hematopoietic Stem cell dysfunction and bone marrow failure
- Poly (ADP-Ribose) Polymerases in Aging–Friend or Foe?
- The functional interplay between syStemic cancer and the hematopoietic Stem cell niche
- High glutathione and glutathione peroxidase-2 levels mediate cell -type-specific DNA damage protection in human induced pluripotent Stem cells
- Regulation of T cell differentiation and function by EZH2
- Coenzyme Q10 inhibits the aging of mesenchymal Stem cells induced by D-galactose through Akt/mTOR signaling
- Runx1 deficiency decreases ribosome biogenesis and confers stress resistance to hematopoietic Stem and progenitor cells
- Nanog down-regulates the Wnt signaling pathway via β-catenin phosphorylation during epidermal Stem cell proliferation and differentiation
- Clonal hematopoiesis of indeterminate potential: a risk factor for hematologic neoplasms
- DNA damage-induced HSPC malfunction depends on ROS accumulation downstream of IFN-1 signaling and bid mobilization
- Runx1 downregulates Stem cell and megakaryocytic transcription programs that support niche interactions
- Dystrophin expression in muscle Stem cells regulates their polarity and asymmetric division
- An emerging interplay between altered human lipid metabolism, lipodystrophy and aging
- Foxc1 reinforces quiescence in self-renewing hair follicle Stem cells
- Loss of Sfrp2 in the Niche Amplifies Stress-Induced Cellular Responses, and Impairs the In Vivo Regeneration of the Hematopoietic Stem cell Pool
- Diet‐induced obesity in mice diminishes hematopoietic Stem and progenitor cells in the bone marrow
- Oxidative stress in the aging process: fundamental aspects and new insights
- Blue journal conference. Aging and susceptibility to lung disease
- Analysis of Germline Stem cell Differentiation Following Loss of GLP-1 Notch Activity in Caenorhabditis elegans
- The Role of Cathepsin K in Hematopoiesis
- The Role of U2AF1 Mutations in the Pathogenesis of Myelodysplastic Syndromes
- An in vivo evaluation of aneuploid hematopoietic Stem cell fitness
- Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
- Epigenetic regulations of hematopoietic Stem cells ageing and the regulation of traditional Chinese medicine
- Ageing of the Stem Cells: The Conjoined Twosome Growing Old: Stem cell and Its Niche
- 281. Enforced Expression of a Mutant HMGA2 Gene Leads to Competitive Expansion and High Level Marking of Long-Term Hematopoietic Stem Cells in …
- Loss of niche-satellite cell interactions in syndecan-3 null mice alters muscle progenitor cell homeostasis improving muscle regeneration
- Pituitary Regeneration: It’ll Knock Your SOX Off!
- Dyskeratosis congenita induced cirrhosis for liver transplantation-perioperative management
- 3-Phosphoinositide-dependent kinase-1 (PDK1)-mediated signaling regulates hematopoietic Stem cell (HSC) quiesence by governing the oxidative response
- Stem cell Transplantation for Degenerative Muscle Diseases
- The potential roles of EZH2 in regenerative medicine
- The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer Stem-like cells
- Invertebrates as model organisms for research on aging biology
- Enhancer of zeste homolog 2 is widely expressed in T-cell neoplasms, is associated with high proliferation rate and correlates with MYC and pSTAT3 expression in a …
- Is chronic obstructive pulmonary disease an accelerated aging disease?
- Anti-aging strategies based on cellular reprogramming
- P53 regulates disruption of neuronal development in the adult hippocampus after irradiation
- Androgen therapy in Fanconi anemia: a retrospective analysis of 30 years in Germany
- Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages
- PRC 2 preserves intestinal progenitors and restricts secretory lineage commitment
- Linking the aryl hydrocarbon receptor with altered DNA methylation patterns and developmentally induced aberrant antiviral CD8+ T cell responses
- Satellite cell heterogeneity in skeletal muscle homeostasis
- Dangerous entrapment for NRF2
- Regulation of Stem Cells in Their Niche
- Ageing and the pathogenesis of osteoarthritis
- Epigenetic Modulation: A Promising Avenue to Advance Hematopoietic Stem cell -Based Therapy for Severe Autoimmune Disorders
- CDK7 and miR-210 co-regulate cell -cycle progression of neural progenitors in the developing neocortex
- Association of TGFβ signaling with the maintenance of a quiescent Stem cell niche in human oral mucosa
- Repression of the antioxidant NRF2 pathway in premature aging
- Molecular regulation and rejuvenation of muscle Stem (satellite) cell aging
- mTOR Signaling Promotes Stem cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration
- MERIT40 deficiency expands hematopoietic Stem cell pools by regulating thrombopoietin receptor signaling
- Stem cells: a renaissance in human biology research
- Redox theory of aging
- E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis
- Transplantation of endothelial cells to mitigate acute and chronic radiation injury to vital organs
- Stem cells and aberrant signaling of molecular syStems in skin aging
- Metabolic control of longevity
- Glioblastoma: molecular pathways, Stem cells and therapeutic targets
- Long live FOXO: unraveling the role of FOXO proteins in aging and longevity
- In vivo gene editing in dystrophic mouse muscle and muscle Stem cells
- Clonal evolution of Stem cells in the gastrointestinal tract
- Genomics of Lung Aging and Idiopathic Pulmonary Fibrosis
- Mechanisms involved in the development of the chronic gastrointestinal syndrome in nonhuman primates after total-body irradiation with bone marrow shielding
- EZH2 in normal hematopoiesis and hematological malignancies
- Molecular pathways: targeting cancer Stem cells awakened by chemotherapy to abrogate tumor repopulation
- Inhibition of mTOR sensitizes breast cancer Stem cells to radiation-induced repression of self-renewal through the regulation of MnSOD and Akt
- Aging of Stem and progenitor cells: mechanisms, impact on therapeutic potential, and rejuvenation
- Regenerative biology of tendon: mechanisms for renewal and repair
- Molecular insights into the premature aging disease progeria
- Hair follicle aging is driven by transepidermal elimination of Stem cells via COL17A1 proteolysis
- The role of aging in idiopathic pulmonary fibrosis
- Wnt activity and basal niche position sensitize intestinal Stem and progenitor cells to DNA damage
- Stem cell Aging Research Literatures
- Cardiomyocyte Regeneration in the mdx Mouse Model of Nonischemic Cardiomyopathy
- The Stem cell Niche and Its Role in Self-Renewal, Aging, and Malignancy
- Inflammatory signals in HSPC development and homeostasis: Too much of a good thing?
- Altered gut microbiota composition in Rag1-deficient mice contributes to modulating homeostasis of hematopoietic Stem and progenitor cells
- Heterogeneous Stem Cells in Skin Homeostatis and Wound Repair
- CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic Stem/progenitor cells
- Mesenchymal stromal cell -derived extracellular vesicles promote myeloid-biased multipotent hematopoietic progenitor expansion via toll-like receptor …
- Epigenetic and Pten Regulation of Longevity Pathways Related to Idiopathic Pulmonary Fibrosis and Organismal Aging
- Characterization of bone marrow-derived mesenchymal Stem cells in aging
- Protective effect of ginsenoside Rg1 on hematopoietic Stem/progenitor cells through attenuating oxidative stress and the Wnt/β-catenin signaling pathway in a mouse …
- Effective activity of cytokine induced killer cells against hepatocellular carcinoma including tumor-initiating cells
- Are aberrant phase transitions a driver of cellular aging?
- MUC5B and idiopathic pulmonary fibrosis
- Aging of human haematopoietic Stem cells
- Genome-wide DNA methylation changes during aging
- Aging and uremia: Is there cellular and molecular crossover?
- Paradoxical role of SOX2 in gastric cancer
- Regulatory roles of miRNAs in aging
- Early injury of the neonatal lung contributes to premature lung aging: a hypothesis
- MicroRNA-Mediated Translational Control in Stem Cells: Self-Renewal and Therapeutic Implications
- Epigenetic gene regulation and Stem cell function
- The circadian clock in skin: implications for adult Stem cells, tissue regeneration, cancer, aging, and immunity
- mTOR is necessary for proper satellite cell activity and skeletal muscle regeneration
- Fbw7 and its counteracting forces in Stem cells and cancer: Oncoproteins in the balance
- Understanding age-related diseases: report of the 2015 Ageing Summit
- Loss of RUNX1 function results in enhanced granulocyte-colony-stimulating factor-mediated mobilization
- The impact of leukemic microenvironment on normal hematopoiesis
- Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: a tale of two complexes
- Gastrocnemius medialis muscle architecture and physiological cross sectional area in adult males with Duchenne muscular dystrophy
- Postgraduate haematology
- A comparative view of regenerative neurogenesis in vertebrates
- Prospective study of ocular manifestations of pemphigus and bullous pemphigoid identifies a high prevalence of dry eye syndrome
- Polycomb-like 2 (Mtf2/Pcl2) is required for epigenetic regulation of hematopoiesis
- Correlation of smoking-associated DNA methylation changes in buccal cells with DNA methylation changes in epithelial cancer
- The aging epigenome
- The roles of Polycomb group proteins in hematopoietic Stem cells and hematological malignancies
- Exome and whole genome sequencing in aging and longevity
- Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts
- mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model
- Molecular mechanisms of biological aging in intervertebral discs
- High-throughput screening identifies artesunate as selective inhibitor of cancer Stemness: involvement of mitochondrial metabolism
- Self-renewal and high proliferative colony forming capacity of late-outgrowth endothelial progenitors is regulated by cyclin-dependent kinase inhibitors driven by notch …
- The proliferation of amplifying neural progenitor cells is impaired in the aging brain and restored by the mTOR pathway activation
- Rejuvenation on the Road to Pluripotency
- The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins?
- Sox9-positive progenitor cells play a key role in renal tubule epithelial regeneration in mice
- Role for the aryl hydrocarbon receptor and diverse ligands in oral squamous cell carcinoma migration and tumorigenesis
- Gene Therapy and cell Fusion Enhances Stem cell Mediated Cardiac Repair
- Renal Stem Cells, Tissue Regeneration, and Stem cell Therapies for Renal Diseases
- Strategies to prevent “bad luck” in cancer
- Evolutionarily conserved signaling pathways: acting in the shadows of acute myelogenous leukemia’s genetic diversity
- cell autonomous and non-autonomous effects of senescent cells in the skin
- Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases
- Cutting the brakes on hematopoietic regeneration by blocking TGFβ to limit chemotherapy-induced myelosuppression
- The role of Notch signaling in muscle progenitor cell depletion and the rapid onset of histopathology in muscular dystrophy
- Human artificial chromosomes for Duchenne muscular dystrophy and beyond: challenges and hopes
- Accelerated lung aging in COPD: a lung tissue gene expression signature
- Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands
- CCND1–CDK4–mediated cell cycle progression provides a competitive advantage for human hematopoietic Stem cells in vivo
- Chromosome organisation during ageing and senescence
- Impact of the circadian clock on the aging process
- Proteostatic Mechanisms and Degree of Transcriptional Change with Age in Different Neural Stem cell Populations
- Antisense strategies targeting DUX4 and DUX4c as therapeutic approaches for facioscapulohumeral muscular dystrophy (FSHD)
- Ageing as an important risk factor for cancer
- Increased red cell distribution width in Fanconi anemia: a novel marker of stress erythropoiesis
- Emerging roles of frailty and inflammaging in risk assessment of age-related chronic diseases in older adults: the intersection between aging biology and …
- Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis
- Loss of miR-143 and miR-145 inhibits hematopoietic Stem cell self-renewal via dysregulated TGF-beta signaling
- Pluripotent Stem cells and their dynamic niche
- Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic Stem cells in transplantation and gene therapy
- Anti-aging effect of transplanted amniotic membrane mesenchymal Stem cells in a premature aging model of Bmi-1 deficiency
- Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue
- Deficient activity of the nuclease MRE11A induces T cell aging and promotes arthritogenic effector functions in patients with rheumatoid arthritis
- Multi-drug resistance ABC transporter inhibition enhances murine ventral prostate Stem/progenitor cell differentiation
- Isolation of THY1+ undifferentiated spermatogonia from mouse postnatal testes using magnetic-activated cell sorting (MACS)
- The zebrafish as a gerontology model in nervous syStem aging, disease, and repair
- Women Win Turning Older
- Senescence is involved in the pathogenesis of chronic obstructive pulmonary disease through effects on telomeres and the anti‐aging molecule fibroblast growth …
- Targeted Therapy in Myelodysplastic Syndromes
- Distinct germline progenitor subsets defined through Tsc2–mTORC 1 signaling
- Concise review: custodians of the transcriptome: how microRNAs guard Stemness in squamous epithelia
- Aging of Mammalian Intestinal Stem Cells
- RUNX1B expression is highly heterogeneous and distinguishes megakaryocytic and erythroid lineage fate in adult mouse hematopoiesis
- Long-lasting WNT-TCF response blocking and epigenetic modifying activities of Withanolide F in human cancer cells
- Do we need more drugs for chronic myeloid leukemia?
- cell Competition: Roles and Importance as a Central Phenomenon
- Autophagy regulates the cell cycle of murine HSPCs in a nutrient-dependent manner
- Non-lethal ionizing radiation promotes aging-like phenotypic changes of human hematopoietic Stem and progenitor cells in humanized mice
- Bone microenvironment signals in osteosarcoma development
- Mouse models for core binding factor leukemia
- Isolation of THY1+ Undifferentiated Spermatogonia from Mouse Postnatal Testes Using Magnetic-activated cell Sorting (MACS)
- Epigenetic regulation of muscle Stem cell expansion
- Pharmaceutical rejuvenation of age-associated decline in spatial memory
- Activation of non-myogenic mesenchymal Stem cells during the disease progression in dystrophic dystrophin/utrophin knockout mice
- Medullary thymic epithelial Stem cells: role in thymic epithelial cell maintenance and thymic involution
- Epigenetic Responses to Diet in Aging
- PTEN: multiple functions in human malignant tumors
- Aging and lung disease. Clinical impact and cellular and molecular pathways
- Neuropeptide Y induces hematopoietic Stem/progenitor cell mobilization by regulating matrix metalloproteinase-9 activity through Y1 receptor in osteoblasts
- The role of hydrogen sulfide in aging and age-related pathologies
- Concise review: quiescence in adult Stem cells: biological significance and relevance to tissue regeneration
- Detection and quantification of epithelial progenitor cell populations in human healthy and IPF lungs
- Therapy of endocrine disease: improvement of cardiovascular risk factors after adrenalectomy in patients with adrenal tumors and subclinical Cushing’s …
- Impact of nutrition on the ageing process
- Progerin expression disrupts critical adult Stem cell functions that mediate tissue repair primarily through a mechanism that permanently farnesylates lamin A
- cell therapy strategies to combat immunosenescence
- Probable impact of age and hypoxia on proliferation and microRNA expression profile of bone marrow-derived human mesenchymal Stem cells
- Telomeres and Immunodeficiencies
- Lin28 and let-7 in the metabolic physiology of aging
- Loss of Ezh2 synergizes with JAK2-V617F in initiating myeloproliferative neoplasms and promoting myelofibrosis
- Metabolic restructuring and cell fate conversion
- Low doses of oxygen ion irradiation cause acute damage to hematopoietic cells in mice
- Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases
- Aging Skin: A Window to the Body
- Caloric restriction and the adipokine leptin alter the SDF-1 signaling axis in bone marrow and in bone marrow derived mesenchymal Stem cells
- Characterization of mammary epithelial Stem/progenitor cells and their changes with aging in common marmosets
- MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic Stem cells
- Update on acute myeloid leukemia Stem cells: New discoveries and therapeutic opportunities
- Role of Proteinase 3 in bone marrow hematopoiesis and neutrophil function
- Skeletal muscle fibrosis in the mdx/utrn+/-mouse validates its suitability as a murine model of Duchenne muscular dystrophy
- PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL
- Histone H2B monoubiquitination: roles to play in human malignancy
- The role of aging in Alzheimer’s disease
- Dystrophin: The dead calm of a dogma
- A summary of the biological basis of frailty
- As we age: Does slippage of quality control in the immune syStem lead to collateral damage?
- RUNX1 haploinsufficiency results in granulocyte colony-stimulating factor hypersensitivity
- MINI-SYMPOSIUM 2: CELLULAR AND MOLECULAR MECHANISMS OF FIBROSIS
- Inhibition of Wnt/β-catenin signaling suppresses bleomycin-induced pulmonary fibrosis by attenuating the expression of TGF-β1 and FGF-2
- Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute
- Age-related epigenetic drift and phenotypic plasticity loss: implications in prevention of age-related human diseases
- COUP-TFII regulates satellite cell function and muscular dystrophy
- EZH2 is overexpressed in laryngeal squamous cell carcinoma and enhances the Stem-like properties of AMC-HN-8 cells
- Enforced expression of Hoxa5 in haematopoietic Stem cells leads to aberrant erythropoiesis in vivo
- The aryl hydrocarbon receptor relays metabolic signals to promote cellular regeneration
- Toward RNA repair of Diamond Blackfan Anemia hematopoietic Stem cells
- Effects of Developmental Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Long-term Self-renewal of Murine Hematopoietic …
- Inflammatory markers change with age, but do not fall beyond reported normal ranges
- Tumor Dormancy, Quiescence, and Senescence
- Connecting the dots: from DNA damage and repair to aging
- Aging and adipose tissue: potential interventions for diabetes and regenerative medicine
- Coaxing Stem cells for skeletal muscle repair
- ICL-induced miR139-3p and miR199a-3p have opposite roles in hematopoietic cell expansion and leukemic transformation
- The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors
- GATA2 germline mutations impair GATA2 transcription, causing haploinsufficiency: functional analysis of the p. Arg396Gln mutation
- Emerging non-canonical functions and regulation by p53: p53 and Stemness
- Animal and human models to understand ageing
- Label-retaining stromal cells in mouse endometrium awaken for expansion and repair after parturition
- The African turquoise killifish: a model for exploring vertebrate aging and diseases in the fast lane
- Telomere-regulating genes and the telomere interactome in familial cancers
- Ontogenetic memory of the cell
- Evolutionary ecology of aging: time to reconcile field and laboratory research
- Utilizing murine inducible telomerase alleles in the studies of tissue degeneration/regeneration and cancer
- Acquired tissue-specific promoter bivalency is a basis for PRC2 necessity in adult cells
- AMPK function in aging process
- Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming
- DNA damage-inducible transcript 4 is an innate surveillant of hair follicular stress in vitamin D receptor knockout mice and a regulator of wound re-epithelialization
- A novel lymphoid progenitor cell population (LSKlow) is restricted by p18INK4c
- Adipose-derived mesenchymal Stem cells and their reparative potential in ischemic heart disease
- Increased levels of p21 (CIP1/WAF1) correlate with decreased chondrogenic differentiation potential in synovial membrane progenitor cells.
- On the occasion of world kidney day 2016; work together to better protect the kidney
- Accelerated apoptosis of peripheral blood monocytes in Cebpb-deficient mice
- CD49f acts as an inflammation sensor to regulate differentiation, adhesion, and migration of human mesenchymal Stem cells
- Frailty for surgeons: review of a national institute on aging conference on frailty for specialists
- Mutations in AML: prognostic and therapeutic implications
- PRC2 inhibition counteracts the culture-associated loss of engraftment potential of human cord blood-derived hematopoietic Stem and progenitor cells
- A small molecule screen exposes mTOR signaling pathway involvement in radiation-induced apoptosis
- Epigenetics of hematopoiesis and hematological malignancies
- THE EFFECT OF BONE MARROW DERIVED Stem CELLS ON AGE CHANGES OF SUBMANDIBULAR SALIVARY GLANDS (HISTOLOGICAL AND …
- The mechanobiology of aging
- PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells
- Receptor-interacting protein 140 overexpression promotes neuro-2a neuronal differentiation by ERK1/2 signaling
- Identification of factors promoting ex vivo maintenance of mouse hematopoietic Stem cells by long-term single-cell quantification
- Muscle satellite cells: exploring the basic biology to rule them
- Current research in aging: a report from the 2015 Ageing Summit
- Hierarchal autophagic divergence of hematopoietic syStem
- Cancer Stem Cells: Perspectives Beyond Immunophenotypes and Markers
- Satellite cells and skeletal muscle regeneration
- Oxidative stress, microRNAs and cytosolic calcium homeostasis
- Phosphatase and tensin homologue: novel regulation by developmental signaling
- Pluripotent Stem cells for gene therapy of degenerative muscle diseases
- Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscle
- The delayed effects of acute radiation syndrome: evidence of long-term functional changes in the clonogenic cells of the small intestine
- Rheumatoid arthritis, immunosenescence and the hallmarks of aging
- Pharmacologic inhibition of JAK-STAT signaling promotes hair growth
- Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy
- cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors
- Replicating through telomeres: a means to an end
- Elimination of the geomagnetic field stimulates the proliferation of mouse neural progenitor and Stem cells
- Patient-Derived Induced Pluripotent Stem Cells Provide a Regenerative Medicine Platform for Duchenne Muscular Dystrophy Heart Failure
- Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic
- The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic Stem cells
- Changes in regenerative capacity through lifespan
- The initial establishment and epithelial morphogenesis of the esophagus: a new model of tracheal–esophageal separation and transition of simple columnar into …
- cell ageing: a flourishing field for neurodegenerative diseases
- Derivation of Engrafting Skeletal Muscle Precursors from Human Embryonic Stem Cells Using Serum-Free Methods
- Efficient derivation and inducible differentiation of expandable skeletal myogenic cells from human ES and patient-specific iPS cells
- Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic Stem cells
- Targeting cell cycle regulators in hematologic malignancies
- Anemia, fatigue and aging
- An Updated Review On Hutchinson-Gilford Progeria Syndrome
- Premature aging in chronic kidney disease and chronic obstructive pulmonary disease: similarities and differences
- How Wnt/β-Catenin, TGF-β/BMP signalling effect senescence via polycomb.
- Evidence for the hallmarks of human aging in replicatively aging yeast
- Deregulation of the pRb-E2F4 axis alters epidermal homeostasis and favors tumor development
- New trends in aryl hydrocarbon receptor biology
- Loss of B cells in patients with heterozygous mutations in IKAROS
- A comprehensive transcriptomic analysis of differentiating embryonic Stem cells in response to the overexpression of Mesogenin 1
- Hutchinson–Gilford progeria syndrome
- Blood Disorders in the Elderly
- Halofuginone promotes satellite cell activation and survival in muscular dystrophies
- What we know about the pathogenesis of idiopathic pulmonary fibrosis
- A Novel Mechanism of Spermatogonia Death in Drosophila that Contributes to Tissue Homeostatis During Starvation.
- C/EBPα in normal and malignant myelopoiesis
- The impact of aging on cancer progression and treatment
- Relative leukocyte telomere length, hematological parameters and anemia-data from the Berlin Aging Study II (BASE-II)
- Age-related increase of EED expression in early hematopoietic progenitor cells is associated with global increase of the histone modification H3K27me3
- Kindler syndrome, an orphan disease of cell /matrix adhesion in the skin–molecular genetics and therapeutic opportunities
- Cancer and frailty in older adults: a nested case-control study of the Mexican Health and Aging Study
- Regenerative Cells in the Ageing Lung
- Current translational research and murine models for Duchenne muscular dystrophy
- The Role of Age in Cellular Responses to Microenvironmental Cues as a Breast Cancer Susceptibility Factor
- Differential proteomic analysis of human placenta-derived mesenchymal Stem cells cultured on normal tissue culture surface and hyaluronan-coated surface
- Radiation Sensitivity of Human CD34+ Cells Versus Peripheral Blood T Lymphocytes of Newborns and Adults: DNA Repair and Mutagenic Effects
- The RUNX family: developmental regulators in cancer
- DNA repair and aging: the impact of the p53 family
- Hepatic angiosarcoma with dyskeratosis congenita
- Primordial germ cells and germ line Stem cells
- Host age is a syStemic regulator of gene expression impacting cancer progression
- Dietary protein, metabolism, and aging
- Epigenetics of idiopathic pulmonary fibrosis
- mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
- Signaling networks determining life span
- Improvement of skeletal muscle performance in ageing by the metabolic modulator Trimetazidine
- Irreversible LSD1 inhibitors: application of tranylcypromine and its derivatives in cancer treatment
- Nothobranchius furzeri: a model for aging research and more
- Classification for longevity potential: the use of novel biomarkers
- BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis
- Id1 deficiency protects against tumor formation in ApcMin/+ mice but not in a mouse model of colitis-associated colon cancer
- Atlas of cellular dynamics during zebrafish adult kidney regeneration
- A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate
- Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas
- Telomerase and the Male Germline
- The role of PI3K/AKT/mTOR inhibitors in the treatment of hematological malignancies
- Genome-and cell -based strategies in therapy of muscular dystrophies
- Influence of miR-155 on cell apoptosis in rats with ischemic stroke: role of the ras homolog enriched in brain (Rheb)/mTOR pathway
- Epigenetics of aging
- Posttranslational modifications of RUNX1 as potential anticancer targets
- Practical Laboratory Medicine
- Nutrients and ageing: what can we learn about ageing interactions from animal biology?
- Adhesion receptors involved in HSC and early-B cell interactions with bone marrow microenvironment
- Histone H2A deubiquitinase Mysm1 regulates p53 pathway activity in hematopoietic cells
- Welcome to My Research! layer
- Conservative growth hormone/IGF-1 and mTOR signaling pathways as a target for aging and cancer prevention: do we really have an antiaging drug?
- The impact of lung cancer on survival of idiopathic pulmonary fibrosis
- Metabolic Control of Longevity
- Identification of novel microRNA signatures linked to acquired aplastic anemia
- Mesenchymal stromal cell -based therapies for lung disease
- Ageing and the telomere connection: An intimate relationship with inflammation
- Identifying high-risk adult AML patients: epigenetic and genetic risk factors and their implications for therapy
- Biomarkers of replicative senescence revisited
- Exercise attenuates the major hallmarks of aging
- Mapping the MYSM1 Transcriptional Network in Hematopoietic Stem and Progenitor Cells
- Epigenetic modifications and accumulation of DNA double-strand breaks in oral lichen planus lesions presenting poor response to therapy
- Megakaryocytic transcription factors in disease and leukemia
- Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2
- Muscular dystrophy in the mdx mouse is a severe myopathy compounded by hypotrophy, hypertrophy and hyperplasia
- Mitophagy plays a central role in mitochondrial ageing
- The Dnmt3L ADD domain controls cytosine methylation establishment during spermatogenesis
- Combinations of kinase inhibitors protecting myoblasts against hypoxia
- Oxidative stress-mediated skeletal muscle degeneration: molecules, mechanisms, and therapies
- Molecules to medicine with mTOR: translating critical pathways into novel therapeutic strategies
- MEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis
- Arantzazu Alfranca, Lucia Martinez-Cruzado, Juan Tornin, Ander Abarrategi, Teresa Amaral, Enrique de
- Histogenesis of keratoacanthoma: histochemical and immunohistochemical study
- Molecular basis of telomere dysfunction in human genetic diseases
- Commentary: life course epidemiology embraces geroscience
- Overexpression of PRAS40T246A in the proliferative compartment suppresses mtorc1 signaling, keratinocyte migration, and skin tumor development
- Fate mapping and quantitation of hematopoiesis in vivo
- LMNA Mutation c.917T>G (p.L306R) Leads to Deleterious Hyper‐Assembly of Lamin A/C and Associates with Severe Right Ventricular Cardiomyopathy and …
- Telomere dysfunction, chromosomal instability and cancer
- EPIGENETIC SIGNIFICANCE OF CHROMATIN STRUCTURE IN CELLULAR AGEING
- The role of osteocytes in age-related bone loss
- Mechanisms of action of curcumin on aging: nutritional and pharmacological applications
- Lack of Aryl Hydrocarbon Receptor Alters Gene Expression and Functional Capacity of Murine Hematopoietic Stem Cells
- The molecular basis and clinical significance of genetic mutations identified in myelodysplastic syndromes
- Age gene expression and coexpression progressive signatures in peripheral blood leukocytes
- An update on the pathophysiology of osteoarthritis
- H3K27 methylation: a focal point of epigenetic deregulation in cancer
- Specific premature epigenetic aging of cartilage in osteoarthritis
- SyStemic sclerosis-associated fibrosis: an accelerated aging phenotype?
- A role for Galgt1 in skeletal muscle regeneration
- A mitochondrial perspective of chronic obstructive pulmonary disease pathogenesis
- Roles for the polycomb group protein BMI1 in lung adenocarcinoma progression and maintenance
- Aging-related inflammation in osteoarthritis
- Energetic interventions for healthspan and resiliency with aging
- ROLE OF THE POLYCOMB GROUP PROTEINS IN THE ADULT INTESTINAL Stem CELLS HOMEOSTASIS
- From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?
- The Role of Non-Myogenic Mesenchymal Stem Cells in Skeletal Muscle of Dystrophin/Utrophin Double Knockout Mice
- Harnessing the Power of Stem Cells in Vaccine Against Mycobacterium tuberculosis
- Epithelial Stem cells In Hutchinson-Gilford progeria syndrome
- SyStemic DNA damage responses in aging and diseases
- Impact of Leishmania donovani infection on early events in haematopoiesis
- The regulation of satellite cell function and myogenesis by isoforms of C/EBPβ
- Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice
- Aging and multimorbidity: new tasks, priorities, and frontiers for integrated gerontological and clinical research
- Biomarkers in Interstitial lung diseases
- USP11 is a negative regulator to γH2AX ubiquitylation by RNF8/RNF168
- Biomolecular bases of the senescence process and cancer. A new approach to oncological treatment linked to ageing
- Influence of aging on proliferation, pluripotency, immunogenic profiles from bone marrow mesenchymal Stem cells
- An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium
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- 7, 12-Dimethylbenz (a) anthracene-induced genotoxicity on bone marrow cells from mice phenotypically selected for low acute inflammatory response
- The fine tuning of metabolism, autophagy and differentiation during in vitro myogenesis
- Retinoid chemoprevention: who can benefit?
- Why is aging conserved and what can we do about it?
- Antioxidant potential of phycobiliproteins: Role in anti-aging research
- Research & Reviews: Research Journal of Biology
- MicroRNAs as potential targets for progressive pulmonary fibrosis
- The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain
- Nonspecific interstitial pneumonia: what is the optimal approach to management?
- Telomeres in Liver Transplantation Allografts
- Dystrophin induced cognitive impairment: mechanisms, models and therapeutic strategies
- The Intrinsic Apoptotic Cascade in Hematopoiesis and Susceptibility to Therapy-Related Leukemia
- Cellular senescence and autophagy in the pathogenesis of chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF)
- An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation
- Extended clinical and genetic spectrum associated with biallelic RTEL1 mutations
- Poloxamer 188 attenuates cerebral hypoxia/ischemia injury in parallel with preventing mitochondrial membrane permeabilization and autophagic activation
- Interaction between Bovine leukemia virus (BLV) infection and age on telomerase misregulation
- Prevalence of Obstructive Sleep Apnoea in Patients with Idiopathic Pulmonary Fibrosis
- Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development
- Replicating through telomeres: a means to an end.
- Characterizing the functional role of argonaute protein PIWIL4 in acute myeloid leukemia
- Disturbing the histone code in leukemia: translocations and mutations affecting histone methyl transferases
- The importance of detailed epigenomic profiling of different cell types within organs
- HIV and aging
- Drug discovery of therapies for duchenne muscular dystrophy
- Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation
- Connective tissue diseases, multimorbidity and the ageing lung
- Disease drivers of aging
- The Impact of Cancer Treatments on Aging
- Role of sirtuins in maintenance of genomic stability: relevance to cancer and healthy aging
- Ageing and inflammation–a central role for mitochondria in brain health and disease
- Safety considerations for epigenetic mechanisms as drug targets: Are existing toxicology studies fit for purpose
- Stop Aging Disease! ICAD 2014
- Epigenetic modifiers in normal and malignant hematopoiesis
- Does EBV alter the pathogenesis of malaria?
- TeloPIN: a database of telomeric proteins interaction network in mammalian cells
- Mitochondrial form, function and signalling in aging
- M1 and M2 functional imprinting of primary microglia: role of P2X7 activation and miR-125b
- Defects in homologous recombination repair behind the human diseases: FA and HBOC
- Rheumatoid arthritis, immunosenescence and the hallmarks of aging
- DNA damage: a main determinant of vascular aging
- An aryl hydrocarbon receptor-mediated amplification loop that enforces cell migration in ER−/PR−/Her2− human breast cancer cells
- The effects of aging on hematopoietic Stem cells
- Biological and clinical significance of chronic herpes virus infection in patients undergoing treatment for myeloid malignancies
- MicroRNA-146a modulates B-cell oncogenesis by regulating Egr1
- Pharmacological strategies to retard cardiovascular aging
- Sensitivity of GBM cells to cAMP agonist-mediated apoptosis correlates with CD44 expression and agonist resistance with MAPK signaling
- Pharyngeal satellite cells undergo myogenesis under basal conditions and are required for pharyngeal muscle maintenance
- Calorie restriction as an intervention in ageing
- Molecular diagnosis and precission therapeutic approaches for telomere biology disorders
- Studying the role of Sirtuin-1 gene in the maintenance of mouse intestinal epithelium
- Bone marrow: A new way of modeling a classic organ
- Idiopathic Pulmonary Fibrosis: Clinical Behavior, Pathogenic Mechanisms and Therapeutic Approach
- Primitive Neural Stem Cells in the Mouse Brain
- Epigenetics in lung fibrosis: from pathobiology to treatment perspective
- Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression
- Expression of CDK7, cyclin H, and MAT1 is elevated in breast cancer and is prognostic in estrogen receptor–positive breast cancer
- Nutrients, foods, dietary patterns and telomere length: Update of epidemiological studies and randomized trials
- Unexpected off-targets and paradoxical pathway activation by kinase inhibitors
- Supplementation with Lactobacillus plantarum WCFS1 prevents decline of mucus barrier in colon of accelerated aging Ercc1−/Δ7 mice
- The protective role of liquiritin in high fructose-induced myocardial fibrosis via inhibiting NF-κB and MAPK signaling pathway
- Telomere and telomerase stability in human diseases and cancer
- Vitamin C, antioxidant status, and cardiovascular aging
- The biology of aging: citizen scientists and their pets as a bridge between research on model organisms and human subjects
- Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age‐related disorders
- Somatic expression of unc-54 and vha-6 mRNAs declines but not pan-neuronal rgef-1 and unc-119 expression in aging Caenorhabditis elegans
- Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 …
- From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?
- Human aging in the post-GWAS era: further insights reveal potential regulatory variants
- Sleep and respiratory sleep disorders in idiopathic pulmonary fibrosis
- Telomere replication stress induced by POT1 inactivation accelerates tumorigenesis
- Chondrosenescence: definition, hallmarks and potential role in the pathogenesis of osteoarthritis
- The inhibitory mechanism of Cordyceps sinensis on cigarette smoke extract-induced senescence in human bronchial epithelial cells
- THE TRUE EFFECTS OF EXERCISE ON HUMAN AGING.
- Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block in acute promyelocytic leukemia
- Elastase levels and activity are increased in dystrophic muscle and impair myoblast cell survival, proliferation and differentiation
- SyStemic Factors Mediate Exercise-Induced Enhancement of Adult Hippocampal Neurogenesis
- Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans
- Photobiomodulatory effects of low intensity laser irradiation on isolated lung cancer Stem cells
- Glutamine in sport and exercise
- Meta-analysis of gene expression reversals in ageing brain
- Effects of aging and short-term dietary restriction on neurogenesis and cellular senescence in the zebrafish (Danio Reio) brain
- Effects of sex steroids on bones and muscles: Similarities, parallels, and putative interactions in health and disease
- The potential of DNA modifications as biomarkers and therapeutic targets in oncology
- The PI3K-mTOR Pathway
- Unraveling variations in ribosome biogenesis activity in the mouse hematopoietic syStem at homeostasis in vivo
- Osteoporosis and mechanisms of skeletal aging
- 22.1 The AOP Concept in the Context of Risk Assessment Procedures
- Structure and function of the telomeric CST complex
- Aging of the immune syStem: focus on inflammation and vaccination
- Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects
- Inhibition of CDK7 bypasses spindle assembly checkpoint via premature cyclin B degradation during oocyte meiosis
- The Neural Progenitor cell (NPC) Niche in the Adult Brain Provides a Target for Neurotoxicity: A Putative Adverse Outcome Pathway for ROS-Induced NPC …
- A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations
- Porcine Models of Muscular Dystrophy
- Suppression of STN1 enhances the cytotoxicity of chemotherapeutic agents in cancer cells by elevating DNA damage
- Mitochondrial Priming and Anti-Apoptotic Dependencies in Aging and Diseased Bone Marrow
- WIPI-mediated autophagy and longevity
- Aging in COPD and idiopathic pulmonary fibrosis
- Jacobs Journal of Gerontology
- Biochemical and Functional Comparisons of mdx and Sgcg−/− Muscular Dystrophy Mouse Models
- A POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plus
- Mechanical overloading increases maximal force and reduces fragility in hind limb skeletal muscle from Mdx mouse
- Lysosomal cathepsins and their regulation in aging and neurodegeneration
- The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans
- Histopathology and cryobiopsy
- The Role of Environmental and Endogenous AHR Ligands in Estrogen Receptor, Progesterone Receptor, Human Epidermal Growth Factor Receptor 2-Negative (ER–/PR– …
- Polyketide-based anti-aging therapeutic development via synthetic enzymology
- High fat diet exacerbates Alzheimer’s disease-related pathology in APPswe/PS1 mice
- The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans
- Mitochondrial and ubiquitin proteasome syStem dysfunction in ageing and disease: two sides of the same coin?
- Oxidative stress, autophagy, epigenetic changes and regulation by miRNAs as potential therapeutic targets in osteoarthritis
- Non-coding RNA repertoires in malignant pleural mesothelioma
- P2RX7 purinoceptor: a therapeutic target for ameliorating the symptoms of duchenne muscular dystrophy
- Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation
- In Silico Screening Based on Predictive Algorithms as a Design Tool for Exon Skipping Oligonucleotides in Duchenne Muscular Dystrophy
- Aplastic anemia: from pathophysiology to diagnosis, management and treatment
- Defective repair of uracil causes telomere defects in mouse hematopoietic cells
- Targeted therapy for idiopathic pulmonary fibrosis: where to now?
- Epigenetics of physiological and premature aging
- Proteasome function is not impaired in healthy aging of the lung
- Differentiation of Human Mesenchymal Stem Cells into Dopaminergic Neurons on Brain Electrode Materials
- Regulation of the embryonic cell cycle during mammalian preimplantation development
- Lipogenesis mitigates dysregulated sarcoplasmic reticulum calcium uptake in muscular dystrophy
- Mechanisms of early hemato-endothelial development from human pluripotent Stem cells
- CST complex and telomere maintenance
- Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships
- Internal Tandem Duplication of FLT3 Deregulates Proliferation and Differentiation and Confers
- Computational biology in human aging: an omics data integration approach
- Phosphoproteomic Characterization Of Glycogen Synthase Kinase-3
- High-Throughput Analysis of Age-Dependent Protein Changes in Layer II/III of the Human Orbitofrontal Cortex
- An oncogenic Ezh2 mutation cooperates with particular genetic alterations to induce tumors in mice and redistributes H3K27 trimethylation throughout the …
- Human CST facilitates genome-wide RAD51 recruitment to GC-rich repetitive sequences in response to replication stress
- Computational Biology in Human Aging
- Autophagy in the hypothalamus: role of Neuropeptide Y and impact on Synaptic Plasticity
- A phosphorylation–deubiquitination cascade regulates the BRCA2–RAD51 axis in homologous recombination
- Maintenance of homeostasis in the aging hypothalamus: the central and peripheral roles of succinate
- Development and Characterization of Tool Compounds Targeting the Runt Domain’s interaction With Cbfβ
- Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice
- Quantitative T2 combined with texture analysis of nuclear magnetic resonance images identify different degrees of muscle involvement in three mouse models …
- Longevity of animals under reactive oxygen species stress and disease susceptibility due to global warming
- Advanced glycation end products and their receptor in age-related, non-communicable chronic inflammatory diseases; Overview of clinical evidence and potential …
- Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs
- Nucleotide excision repair and transcriptional regulation: TFIIH and beyond
- Small-molecule inhibition of functionally related transcriptional co-factors produces synergistic effects in T-cell acute lymphoblastic leukemia
- Are invertebrates relevant models in ageing research? Focus on the effects of rapamycin on TOR
- Dystrophinopathies
- mTOR: a novel therapeutic target for diseases of multiple syStems
- Autophagy and cellular senescence in lung diseases
- The short-lived African turquoise killifish: an emerging experimental model for ageing
- Epigenetic significance of chromatin organization during cellular aging and organismal lifespan
- Revista de
- The role of the aryl hydrocarbon receptor in megakaryocyte development
- Biochemical pathways regulating mammary epithelial cell homeostasis and differentiation
- Evaluation atraumatique de modèles murins de maladies musculaires génétiques
- Nutrition in the Elderly: General Aspects
- AKTIP/Ft1, a new shelterin-interacting factor required for telomere maintenance
- Modeling and analysis of acute leukemia using human hematopoietic Stem and progenitor cells
- Modeling heart disease of patients with muscular dystrophy using induced pluripotent Stem cells
- When anti-aging studies meet cancer chemoprevention: can anti-aging agent kill two birds with one blow?
- The Hormone Nuclear Receptor DHR96 and its role in Ageing
- Cross talk between fanconi anemia and unc5a signaling pathway
- Ulm University Medicine| 2015: Research and Teaching
- Congenital and Acquired Bone Marrow Failure
- Mesenchymal-epidermal interactions in hair follicle cycling and regeneration
- Inhibition of bone remodeling by anti-resorptive drugs displaces the plasma cell niche into the spleen
- ICAM-1 in skeletal muscle disease and regeneration
- Notable decrease in transcriptome conservation during mammalian aging
- The Role of JAK2V617F-positive Endothelial Cells in Aberrant Haemostasis and Thrombosis
- Therapeutic potential of retinoic acid-loaded nanoparticles for brain repair
- Fibrosis: A Failure of Normal Repair and a Common Pathway to Organ Failure
- A Mouse Model of Adynamic Bone Disease (ABD) and its Consequences on Bone Quality with Age
- The protective role of protein L-isoaspartyl (D-aspartate) O-methyltransferase for maintenance of mitochondrial morphology in A549 cell
- Characterizing miR-146a and miR-34a in B-cell lymphomagenesis
- Renal Aging and Transplantation
- Multitasking Roles for Poly (ADP-ribosyl) ation in Aging and Longevity
- The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins
- Bone Marrow Microenvironment regulation of BCL6 in Acute Lymphoblastic Leukemia
- Evolution of the Telomere-Associated Protein POT1a in Arabidopsis thaliana Is Characterized by Positive Selection to Reinforce Protein–Protein Interaction
- Mouse Models of Muscular Dystrophy and Type 2 Diabetes
- Human Population Studies of Transcriptome-wide Expression in Age-related Traits
- Structural Analysis of cell Signaling Complexes
- The design & development of small molecule inhibitors targeting upregulated transcription factors in acute myeloid leukemia
- Central regulation of food intake peptides during ageing in the teleost model Nothobranchius furzeri.
- Age-related epigenetic changes at base excision repair genes and their modulation by dietary restriction in mice
- Here be dragons: Science, technology and the future of humanity
- Fibrocytes, y-Herpesvirus and Periostin Augment Bleomycin-induced Lung Fibrosis.
- MicroRNA expression in regulatory T cells in chronic obstructive pulmonary disease
- A Role for Protein Phosphatase 2A in the Proliferation-Quiescence Decision
- Metal-induced oxidative stress in human fibroblasts: A role in cellular ageing
- Effect of folate status and age on DNA methylation and gene expression
- Identification of longevity and cancer resistance mechanisms in long-lived rodent species
- Metabolic and Redox Effects of Intermittent Fasting
- Investigating novel interaction partners of amyloid precursor protein: the mechanistic target of rapamycin and pikyve complex
- Evaluation of WMircrotracker for assessing C. elegans stress responses
- The role of macrophage migration inhibitory factor in osteoarthritis
- Studies on the regulation of genome maintenance factors by non-covalent interaction with poly (ADP-ribose) with a focus on RECQL helicases
- Connecting the functions of the proteasome and mitochondria in the lung
- The effects of novel anti-inflammatory nutritional and pharmaceutical supplementation during resistance training on muscle and bone in older adults
- An ERK-dependent feedback mechanism prevents hematopoietic Stem cell exhaustion
- Adult Sox2+ Stem cell exhaustion in mice results in cellular senescence and premature aging
- Autophagy in Stem cell aging
- Increased Arf/p53 activity in Stem cells, aging and cancer
- Regulation of Stem cell aging by metabolism and epigenetics
- High‐fat diet–induced obesity promotes expansion of bone marrow adipose tissue and impairs skeletal Stem cell functions in mice
- … Pathway Activation Induced By Combined Loss of Del (5q) MDS Genes, Tifab and Mir-146a, Accelerates Hematopoietic Stem cell exhaustion Driven By Chronic …
- Targeting p53-dependent Stem cell loss for intestinal chemoprotection
- Adult Sox2+ Stem cell exhaustion in mice results in cellular senescence and premature aging
- Critical role of sox2 and p38mapkinase in Stem cell exhaustion , cognitive activity and organismal ageing
- New mechanisms driving muscle Stem cell regenerative decline with aging
- A quiescent Bcl11b high Stem cell population is required for maintenance of the mammary gland
- Regeneration of injured tissue: Stem cell dynamics at interplay with mTORC1
- Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic Stem cells
- Id1 ablation protects hematopoietic Stem cells from stress-induced exhaustion and aging
- Piwi is required to limit exhaustion of aging somatic Stem cells
- Major Disruption of Bone Marrow Stromal cell Networks and Persistent Loss of Hematopoietic Stem cell Function upon Chronic Viral Infection
- The metabolic programming of Stem cells
- Automation in high throughput/content screening for cancer Stem cell drug discovery
- Multiparameter Single cell Analysis to Identify Immune cell States That May Contribute to Successful Treatment Discontinuation in Patients with Chronic Myeloid …
- Loss of Asrij/OCIAD1 in Mice Promotes Hematopoietic Stem and Progenitor cell Expansion Due to Increased CSN5-Mediated P53 Degradation
- Molecular Determinants for Polycomb Group Protein YY1 Control of Hematopoietic Stem cell Quiescence
- Reply to:“Lack of specificity of cytokeratin-15 loss in scarring alopecias”
- Recent advances in understanding Werner syndrome
- Manipulation of hematopoietic Stem cell fate by small molecule compounds
- Cellular and epigenetic drivers of Stem cell ageing
- Polycomb group protein YY1 is an essential regulator of hematopoietic Stem cell quiescence
- Live-Imaging and Genetic Approaches to Study Resident Macrophage Progenitors
- Proliferation drives aging-related functional decline in a subpopulation of the hematopoietic Stem cell compartment
- Signaling pathways regulating hematopoietic Stem cell and progenitor aging
- MYSM1 is essential for maintaining hematopoietic Stem cell (HSC) quiescence and survival
- Recent advances in understanding hematopoiesis in Fanconi Anemia
- Reactive oxygen species and mitochondrial homeostasis as regulators of Stem cell fate and function
- Perspectives of aging study on Stem cell
- Inhibition of BET bromodomain improves anemia in APCmin mice
- Chronic inflammation in immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?
- Altered redox balance in aging process: general mechanistic and clinical aspectseral mechanistic and clinical aspects
- Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult …
- Inflammation: a key regulator of hematopoietic Stem cell fate in health and disease
- Setd2 regulates quiescence and differentiation of adult hematopoietic Stem cells by restricting RNA polymerase II elongation
- Study on the Role of SIRT2 in Stem cell Aging and Chronic Inflammation
- Aging hallmarks: the benefits of physical exercise
- Long-term outcomes of ocular surface Stem cell allograft transplantation
- Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease
- Chronic inflammation in immune aging: role of pattern recognition receptor crosstalk with the telomere complex?
- Obstructive sleep apnea and hallmarks of aging
- The biology of ageing and the omics revolution
- mTORC1 activation during repeated regeneration impairs somatic Stem cell maintenance
- Senescence in COPD and its comorbidities
- Declined presentation loss of tRNA-methylation at cytosine 38 by Dnmt2 induces a hematopoietic Stem cell aging-like phenotype
- Symmetric Stem cell division at the heart of adult neurogenesis
- Aging and Chronic Respiratory Diseases: Novel Mechanisms
- Division-independent differentiation mandates proliferative competition among Stem cells
- The mammary Stem cell field wakes up to hibernating cells
- The spectrum of fundamental basic science discoveries contributing to organismal aging
- Stem cell rejuvenation and the role of autophagy in age retardation by caloric restriction: An update
- Preventing aging with Stem cell rejuvenation: Feasible or infeasible?
- DIABETES ALTERS THE PROGENITOR PHENOTYPE FROM REGENERATIVE TO PRO-INFLAMMATORY: TRANSLATIONAL IMPLICATIONS FOR …
- Scribble controls HSC self-renewal through polarity-dependent activation of the hippo signaling pathway
- Stem cells hide from the sun
- Stem cell Applications in Rejuvenation
- Runx family genes in tissue Stem cell dynamics
- Aging, metabolism and Stem cells: Spotlight on muscle Stem cells
- Enhanced dentate neurogenesis after brain injury undermines long-term neurogenic potential and promotes seizure susceptibility
- Mitochondria and FOXO3 in Stem cell homeostasis, a window into hematopoietic Stem cell fate determination
- Unhealthy Stem cells: when health conditions upset Stem cell properties
- Mammalian sterile 20 kinase 1 and 2 are important regulators of hematopoietic Stem cells in stress condition
- Chronic kidney failure mineral bone disorder leads to a permanent loss of hematopoietic Stem cells through dysfunction of the Stem cell niche
- Hand of FATe: lipid metabolism in hematopoietic Stem cells
- Notch signaling in the regulation of hematopoietic Stem cell
- Relationship between aging and hematopoietic cell transplantation
- Autophagy controls mesenchymal Stem cell properties and senescence during bone aging
- Aging With HIV and Oxidative Stress
- Aged induced pluripotent Stem cell (iPSCs) as a new cellular model for studying premature aging
- RhoA/ROCK inhibition improves the beneficial effects of glucocorticoid treatment in dystrophic muscle: implications for Stem cell depletion
- The mitochondrial respiratory chain is essential for haematopoietic Stem cell function
- TRAF6 mediates basal activation of NF-κB necessary for hematopoietic Stem cell homeostasis
- PDGFB-Expressing Mscs Improves Human Hematopoietic Stem cell Engraftment in Immunodeficient Mice
- Profile of Helen M. Blau
- Hematopoietic Stem Cells: Normal Versus Malignant
- Aging of Human Adult Stem Cells
- Aging of hematopoietic Stem cells
- Meibocyte differentiation and renewal: insights into novel mechanisms of meibomian gland dysfunction (MGD)
- Molecular Switch of AhR in Repression or Activation of Stem cell Signaling
- Distinct molecular signature of murine fetal liver and adult hematopoietic Stem cells identify novel regulators of hematopoietic Stem cell function
- Muscle Stem cells: a model syStem for adult Stem cell biology
- The Basics of Biogerontology
- Endogenous Stem cells in homeostasis and aging
- Pharmacological regulation of oxidative stress in Stem cells
- Induction of muscle Stem cell quiescence by the secreted niche factor Oncostatin M
- Effect of aging on Stem cells
- Unhealthy Stem Cells: When Health Conditions Upset Stem cell Properties
- Blocking EZH2 methylation transferase activity by GSK126 decreases Stem cell -like myeloma cells
- IFN-1 Bid crosstalk: foe or friend to Stem cells
- miRNAs in Stem cell aging and age-related disease
- A Quiescent Bcl11b High Epithelial cell is Required for Mammary Gland Regeneration
- New genetic tools for the in vivo study of hematopoietic Stem cell function
- Proteostatic and metabolic control of Stemness
- Biology of premature ageing in survivors of cancer
- Single Stem cell imaging and analysis reveals telomere length differences in diseased human and mouse skeletal muscles
- Novel therapeutic strategies to target leukemic cells that hijack compartmentalized continuous hematopoietic Stem cell niches
- Genomic instabilities, cellular senescence, and aging: in vitro, in vivo and aging-like human syndromes
- Note: Page numbers followed by f and t indicate figures and tables respectivelyA
- The Stem cell division theory of cancer
- Rejuvenating strategies for Stem cell -based therapies in aging
- Age is relative—impact of donor age on induced pluripotent Stem cell -derived cell functionality
- Stem cell transcription factor FoxO controls microbiome resilience in Hydra
- Tuning of the hematopoietic Stem cell compartment in its inflammatory environment
- Localization of collagen type 5 in the papillary dermis and its role in maintaining Stem cell functions
- Bioenergetics mechanisms regulating muscle Stem cell self-renewal commitment and function
- Key age-imposed signaling changes that are responsible for the decline of Stem cell function
- Chronic obstructive pulmonary disease and the hallmarks of aging
- Comprehensive analysis of age-associated lncRNAs and function prediction in hepatocellular carcinoma
- Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal Stem cell niche
- Unleashing the guardian: the targetable BCR-ABL/HAUSP/PML/PTEN network in chronic myeloid leukemia
- Circadian Rhythms and Their Impact on Aging
- Paradoxical suppression of atherosclerosis in the absence of microRNA-146a
- Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic Stem cells promotes proliferation but reduces competitive fitness
- Muscle Stem cells exhibit distinct clonal dynamics in response to tissue repair and homeostatic aging
- Cyclical expression of GDNF is required for spermatogonial Stem cell homeostasis
- Oxidative stress in mesenchymal Stem cell senescence: regulation by coding and noncoding RNAs
- Organoids with cancer Stem cell -like properties secrete exosomes and HSP90 in a 3D nanoenvironment
- Mesenchymal Stem cells for frailty?
- On the relationship between aging & cancer
- General Introduction Aging of Hematopoietic Stem cells
- Hydra, a model syStem for deciphering the mechanisms of aging and resistance to aging
- Multi‐tasking epidermal Stem cells: Beyond epidermal maintenance
- Role of muscle Stem cells in sarcopenia
- Keeping the rhythm while changing the lyrics: circadian biology in aging
- Comparison of nucleus pulposus Stem/progenitor cells isolated from degenerated intervertebral discs with umbilical cord derived mesenchymal Stem cells
- Aspartic acid racemization on aging
- Senolytic drugs in respiratory medicine: is it an appropriate therapeutic approach?
- Role of MicroRNA-146a in Vascular Inflammation and Atherosclerosis
- cell umbrella protects Stem cells from DNA damage
- 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD)-mediated deregulation of myeloid and sebaceous gland Stem/progenitor cell homeostasis
- Plasticity of the muscle Stem cell microenvironment
- Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury
- Epigenetic control of CXCL10: regulating the counterregulator in idiopathic pulmonary fibrosis
- Molecular mechanisms to develop myeloid neoplasms by RUNX1 or MLL chimeras in human CD34+ cells
- The mystery of longevity in Cilento: a mix of a good dose of genetic predisposition and a balanced diet based on the Mediterranean model
- Identification of slow-cycling germline Stem cells and their regulation by PLZF
- Transient CDK4/6 inhibition protects hematopoietic Stem cells from chemotherapy-induced exhaustion
- Characterization of the ventricular-subventricular Stem cell niche during human brain development
- A novel paradigm links mitochondrial dysfunction with muscle Stem cell impairment in sepsis
- Note: Page numbers followed by f and t indicate figures and tables
- Ectopic microRNAs used to preserve human mesenchymal Stem cell potency and epigenetics
- Cxcr4-haploinsufficient bone marrow transplantation corrects leukopenia in an unconditioned WHIM syndrome model
- A call to action in hematologic disorders: A report from the ASH scientific workshop on hematology and aging
- CD41/CD61bright high ploidy megakaryocytes are critical for platelet production
- Muscle Stem cell dysfunction impairs muscle regeneration in a mouse model of Down syndrome
- Roles of the RUNX1 Enhancer in Normal Hematopoiesis and Leukemogenesis
- Stem cells and DNA repair capacity: muse Stem cells are among the best performers
- Role of epigenetic modulation in cancer Stem cell fate
- mTOR as regulator of lifespan, aging, and cellular senescence: a mini-review
- Pten is necessary for the quiescence and maintenance of adult muscle Stem cells
- Ascorbic acid inhibits senescence in mesenchymal Stem cells through ROS and AKT/mTOR signaling
- Anti-aging action of PPARs: Potential therapeutic targets
- Immunomodulatory drugs downregulate IKZF1 leading to expansion of hematopoietic progenitors with concomitant block of megakaryocytic maturation
- Hematopoietic Stem cells under pressure
- Do hematopoietic Stem cells get old?
- The Multi-pronged regulation of adult neurogenesis by forkhead box o family members
- An essential role of CBL and CBL-B ubiquitin ligases in mammary Stem cell maintenance
- Concise review: cell therapy for critical limb ischemia: an integrated review of preclinical and clinical studies
- Checkpoint kinase 1 is essential for establishing fetal haematopoiesis and hematopoietic Stem and progenitor cell survival
- Eco-aging: Stem cells and microbes are controlled by aging antagonist FoxO
- Integrin‐FAK‐CDC42‐PP1A signaling gnaws at YAP/TAZ activity to control incisor Stem cells
- CD133+ cells derived from skeletal muscles of Duchenne muscular dystrophy patients have a compromised myogenic and muscle regenerative capability
- Stem Cells in Clinical Practice and Tissue Engineering
- Senescence in health and disease
- Methods and strategies for procurement, isolation, characterization, and assessment of senescence of human mesenchymal Stem cells from adipose tissue
- Inhibition of methyltransferase Setd7 allows the in vitro expansion of myogenic Stem cells with improved therapeutic potential
- ALTERED REDOX BALANCE IN AGING PROCESS: GENERAL MECHANISTIC AND CLINICAL ASPECTS
- Stem cell Therapies in Peripheral Vascular Diseases—Current Status
- The Relevance of Induced Pluripotent Stem Cells for the Study of Physiological and Premature Aging
- Proteasome activation enhances Stemness and lifespan of human mesenchymal Stem cells
- A comprehensive analysis of differentially ex-pressed transcripts during hematopoietic Stem cell aging in the mouse
- Wnt/β-catenin signaling promotes aging-associated hair graying in mice
- ASXL1 AND EZH2
- Nuclear pore complexes in DNA repair and telomere maintenance
- PTEN mediates activation of core clock protein BMAL1 and accumulation of epidermal Stem cells
- The histone variant macroH2A confers functional robustness to the intestinal Stem cell compartment
- Mechanisms of lung aging
- Lack of specificity of cytokeratin-15 loss in scarring alopecias
- Wnt signalling in intestinal Stem cells: lessons from mice and flies
- mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level
- Dual role of the anaphase promoting complex/cyclosome in regulating Stemness and differentiation in human primary keratinocytes
- Short telomeres induce p53 and autophagy and modulate age-associated changes in cardiac progenitor cell fate
- Defining adult Stem cells by function, not by phenotype
- mTOR signaling plays a critical role in the defects observed in muscle‐derived Stem/progenitor cells isolated from a murine model of accelerated aging
- Analysis of senescence-related differentiation potentials and gene expression profiles in human dental pulp Stem cells
- ADVANCE ARTICLE
- DNMT3A in Leukemia
- Telomeres in health and disease
- Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?
- Investigating the role of the CCT chaperonin in Stem cell identity and aging
- Stem cells seen through the FOXO lens: an evolving paradigm
- Investigating the regenerative effects of adipose-derived mesenchymal Stem cell conditioned media on sarcopenic and progeric skeletal muscle
- A storm in the niche: Iron, oxidative stress and haemopoiesis
- Methylation maintains HSC division fate
- Regeneration of the aging lung: a mini-review
- Heterogeneity of GATA2-related myeloid neoplasms
- A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models
- Rapamycin prolongs the survival of corneal epithelial cells in culture
- Stem cells, cancer, and MUSASHI in blood and guts
- FOXO transcriptional factors and long-term living
- Persistent elevation of plasma thrombopoietin levels after treatment in severe aplastic anemia
- Rapamycin rescues BMP mediated midline craniosynostosis phenotype through reduction of mTOR signaling in a mouse model
- OCIAD1 controls electron transport chain complex I activity to regulate energy metabolism in human pluripotent Stem cells
- The potential of iPSCs for the treatment of premature aging disorders
- Differential expression of mTOR signaling pathway proteins in lichen planopilaris and frontal fibrosing alopecia
- Secretory phospholipase A2-IIA overexpressing mice exhibit cyclic alopecia mediated through aberrant hair shaft differentiation and impaired wound healing …
- The critical role of inflammation in the pathogenesis and progression of myeloid malignancies
- At the crossroads between neurodegeneration and cancer: a review of overlapping biology and its implications
- Satellite cell -mediated breast muscle regeneration decreases with broiler size
- mTOR signaling in Stem and progenitor cells
- Long telomeres protect against age-dependent cardiac disease caused by NOTCH1 haploinsufficiency
- Bone marrow mesenchymal Stem cells: aging features and relevant treatments
- Mechanisms of hematopoietic Stem cell ageing and targets for hematopoietic tumour prevention
- Frailty and anesthesia
- Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery
- Myelopoiesis in the context of innate immunity
- Hematopoietic Stem cell maintenance in steady-state and inflammation
- Advanced glycation and aging
- The secretome of MUSE cells contains factors that may play a role in regulation of Stemness, apoptosis and immunomodulation
- Maintenance of redox homeostasis by hypoxia-inducible factors
- Therapeutic potential, challenges and future perspective of cancer Stem cells in translational oncology: a critical review
- cell Reprogramming: Mirage or Reality
- Activation of neural Stem cells from quiescence drives reactive hippocampal neurogenesis after alcohol dependence
- The syStem capacity view of aging and longevity
- Memory beyond immunity
- Elderly human hematopoietic progenitor cells express cellular senescence markers and are more susceptible to pyroptosis
- Isolation and prolonged expansion of oral mesenchymal Stem cells under clinical-grade, GMP-compliant conditions differentially affects “Stemness” properties
- Towards a biological geriatric assessment
- Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells
- Conditional deletion of Ahr alters gene expression profiles in hematopoietic Stem cells
- The biology of ageing
- Therapies Targeting Leukemic Stem Cells
- Malaria-induced remodelling of the bone marrow microenvironment mediates loss of haematopoietic Stem cell function
- Proteolytic Networks at the Crossroads of Cancer cell Life and Death: Cancer Stem cell Deciding cell Fate
- Aryl hydrocarbon receptor (AHR) is a novel druggable pathway controlling malignant progenitor proliferation in chronic myeloid leukemia (CML)
- Modifying progression of aging and reducing the risk of neurodegenerative diseases by probiotics and synbiotics
- Children living with progeria
- Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies
- Stem Cells and Tissue Regeneration
- Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice
- Clonal hematopoiesis in aging
- Total body irradiation tremendously impair the proliferation, differentiation and chromosomal integrity of bone marrow-derived mesenchymal stromal Stem cells
- Bone marrow failure
- Visualization of PAX7 protein dynamics in muscle satellite cells in a YFP knock-in-mouse line
- Reflections on aging and wisdom
- Oxidative Stress in Mesenchymal Stem cell Senescence: Regulation by Coding and Noncoding RNAs. Antioxidants and Redox Signaling, 29 (9), 864-879 …
- 9 Aging Epigenetics
- Cellular and molecular mechanisms of sarcopenia: the S100B perspective
- Niche Regulation of Muscle Stem cell Quiescence by Classical Cadherins
- From TCDD-mediated toxicity to searches of physiologic AHR functions
- Ribonucleotide excision repair is essential to prevent squamous cell carcinoma of the skin
- RNA editing-dependent epitranscriptome diversity in cancer Stem cells
- Dynamics of epigenome and 3D genome in hematopoietic Stem cell development
- Meis1 is critical to the maintenance of human acute myeloid leukemia cells independent of MLL rearrangements
- Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis
- Human iPSC models to study orphan diseases: muscular dystrophies
- Clearance of senescent cells: an immunotherapeutic approach
- Notch and aryl hydrocarbon receptor signaling impact definitive hematopoiesis from human pluripotent Stem cells
- Persistent inflammation, immunosuppression and catabolism after severe injury or infection
- Research progress of intervertebral disc endogenous Stem cells for intervertebral disc regeneration
- Impact of oxidative stress on telomere biology
- Stem cell -based Modalities: From Basic Biology to Integration and Regeneration
- Stem Cells as a Therapeutic Modality in Muscular Dystrophy
- Assessment of TREC, KREC and telomere length in long-term survivors after allogeneic HSCT: the role of GvHD and graft source and evidence for telomere …
- Pulmonary Disease in the Aging Patient
- Notch/Wnt Cross-Signalling Regulates Stemness Of Dental Pulp Stem Cells Through Expression Of Neural Crest And Core Pluripotency Factors
- Characterizing the cellular diversity and molecular signatures within the hair follicle dermal Stem cell lineage
- Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7
- Skeletal muscle metabolism: from tissue to Stem cell
- Nucleosome remodelling, DNA repair and transcriptional regulation build negative feedback loops in cancer and cellular ageing
- Evaluating intrinsic and non-intrinsic cancer risk factors
- Mesenchymal Stem cells for the treatment of idiopathic pulmonary fibrosis
- The role of matrix metalloproteinases in aging: Tissue remodeling and beyond
- Commentary:” Promoting Myelin Repair through In vivo Neuroblast Reprogramming”
- What’s in a name? That which we call IPF, by any other name would act the same
- Proceedings: regenerative medicine for lung diseases: a CIRM workshop report
- Mitochondria and Stem cell function: from somatic cells to iPSC-based disease modeling
- Changing mutational and adaptive landscapes and the genesis of cancer
- Secretome analysis of in vitro aged human mesenchymal Stem cells reveals IGFBP7 as a putative factor for promoting osteogenesis
- Discrete signaling mechanisms of mTORC1 and mTORC2: Connected yet apart in cellular and molecular aspects
- Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases
- Wnt signaling in adult epithelial Stem cells and cancer
- Rehmannia glutinosa exhibits anti‐aging effect through maintaining the quiescence and decreasing the senescence of hematopoietic Stem cells
- Stabilization Of Disease Progression In A Case Of Duchenne Muscular Dystrophy With Cellular Transplantation
- Mechanisms of vascular aging
- Chronic infection stunts macrophage heterogeneity and disrupts immune-mediated myogenesis
- Critical Assessment of the mdx Mouse with Ex Vivo Eccentric Contraction of the Diaphragm Muscle
- MicroRNAs-103/107 regulate autophagy in the epidermis
- Mouse models to disentangle the hallmarks of human aging
- Tissue engineering and regenerative medicine: a translational research for antiaging strategy
- RUNX transcription factors at the interface of Stem cells and cancer
- Cancer-associated PIK3CA mutations in overgrowth disorders
- Increased frequency of bronchiolar histotypes in lung carcinomas associated with idiopathic pulmonary fibrosis
- Molecular and physiological manifestations and measurement of aging in humans
- Aging: somatic mutations, epigenetic drift and gene dosage imbalance
- Cross-organelle communication at the core of longevity
- Development and characterization of a bone marrow Stem cell niche model
- mTORC1 activates PASK-Wdr5 signaling to epigenetically connect the nutrient status with myogenesis
- Why we age–a new evolutionary view
- Regenerative medicine: induced pluripotent Stem cells and their benefits on accelerated bone tissue reconstruction using scaffolds
- Aging and the immune syStem: An overview
- Impaired mRNA expression of the migration related chemokine receptor CXCR4 in mesenchymal Stem cells of COPD patients
- Modelling age-associated diseases using transgenic progerin expression
- UHRF1 licensed self-renewal of active adult neural Stem cells
- Age-related changes in nucleus pulposus mesenchymal Stem cells: an in vitro study in rats
- Making gene editing a therapeutic reality
- Aging and autophagy in hematopoietic Stem cells
- The guardian of the genome revisited: p53 downregulates genes required for telomere maintenance, DNA repair, and centromere structure
- DNA damage signaling mediates the functional antagonism between replicative senescence and terminal muscle differentiation
- Functional relevance of miRNAs in premature ageing
- Unveiling epigenetic regulation in cancer, aging, and rejuvenation with in vivo reprogramming technology
- Visualizing hematopoiesis as a stochastic process
- Senescence and aging: Causes, consequences, and therapeutic avenues
- Modulation of myelopoiesis progenitors is an integral component of trained immunity
- and Vijayalakshmi Santhakumar
- Osteogenic niche in the regulation of normal hematopoiesis and leukemogenesis
- Microenvironment-cell nucleus relationship in the context of oxidative stress
- Functional relevance of miRNAs in premature ageing
- Apelin/APJ syStem: a novel promising target for anti-aging intervention
- Introduction to Cardiovascular Aging Compendium: “Aging as the Quintessential Complex Phenotype”
- Blood to Blood: A New Therapeutic Opportunity for Age-Related Diseases
- Hematopoietic Stem/progenitor cell senescence is associated with altered expression profiles of cellular memory-involved gene
- Novel strategies for anti-aging drug discovery
- Elisia D. Tichy, David K. Sidibe, Matthew T. Tierney, 2 Michael J. Stec, 2 Maryam Sharifi-Sanjani
- The role of decidual mesenchymal Stem/stromal cells and their secreted extracellular vesicles in ageing of the human placenta
- Proteostatic and metabolic control of Stemness
- PP242 counteracts glioblastoma cell proliferation, migration, invasiveness and Stemness properties by inhibiting mTORC2/AKT
- Inhibition of Bcl-2/xl with ABT-263 selectively kills senescent type II pneumocytes and reverses persistent pulmonary fibrosis induced by ionizing radiation in mice
- Aging and proteins: what does proteostasis have to do with age?
- Next-generation sequencing and quantitative proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in …
- Epigenetic regulation of skin cells in natural aging and premature aging diseases
- Human aging and cancer: role of miRNA in tumor microenvironment
- The Satellite cell Niche in Skeletal Muscle
- SOX2 haploinsufficiency promotes impaired vision at advanced age
- Circulating markers of ageing and allostatic load: a slow train coming
- Cytomegalovirus retinitis as a presenting feature of multisyStem disorder: Dyskeratosis congenita
- Introductory Chapter: Aging is a Preventable Disorder
- Mammalian skeletal muscle fibres promote non-muscle Stem cells and non-Stem cells to adopt myogenic characteristics
- VU Research Portal
- The Responsibility of Immortality: Welcome to the New Transhumanism
- Targeting glioma Stem cells through combined BMI1 and EZH2 inhibition
- The aging lung: tissue telomere shortening in health and disease
- The role of mTOR-mediated signals during haemopoiesis and lineage commitment
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- Comorbidities, age, and other patient-related predictors of allogeneic hematopoietic cell transplantation outcomes
- Time and the metrics of aging
- Metabolic Regulation of Muscle Stem cell Histone Acetylation Landscape During Regeneration
- Osthole delays Tert-butyl hydroperoxide-induced premature senescence in neural Stem cells
- 5-methoxytryptophan protects MSCs from stress induced premature senescence by upregulating FoxO3a and mTOR
- MicroRNA profiling in cartilage ageing
- Bone microRNAs and ageing
- Why and how are we living longer?
- Changing direction: from therapeutic telomerase inhibition to activation?
- A robust Pax7EGFP mouse that enables the visualization of dynamic behaviors of muscle Stem cells
- Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway
- Aging, inflammation and the environment
- The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9
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- Extracellular vesicles, ageing, and therapeutic interventions
- Agent-based model illustrates the role of the microenvironment in regeneration in healthy and mdx skeletal muscle
- Communication and the Normal Aging Process
- Secrets from immortal worms: what can we learn about biological ageing from the planarian model syStem?
- Asthma in the elderly and late‐onset adult asthma
- New phytochemicals as potential human anti-aging compounds: Reality, promise, and challenges
- Alleviation of senescence and epithelial-mesenchymal transition in aging kidney by short-term caloric restriction and caloric restriction mimetics via …
- Impact of the circadian clock on UV‐induced DNA damage response and photocarcinogenesis
- RUNX1 suppresses breast cancer Stemness and tumor growth
- Regulation of embryonic haematopoietic multipotency by EZH1
- Suppression of Wnt/β-catenin signaling by EGF receptor is required for hair follicle development
- Cohesin in haematopoiesis and leukaemia
- Candidate Interventions for Lifespan Studies
- The prognostic value and potential drug target of phosphatase and tensin homolog in breast cancer patients: a meta-analysis
- Targeting primary acute myeloid leukemia with a new CXCR4 antagonist IgG1 antibody (PF-06747143)
- Wnt signaling in epithelial Stem cells and cancer
- Current methods for skeletal muscle tissue repair and regeneration
- Inflammatory memory sensitizes skin epithelial Stem cells to tissue damage
- Satellite cells delivered in their niche efficiently generate functional myotubes in three-dimensional cell culture
- Spermidine in health and disease
- Sarcopenia: causes and treatments
- Mesenchymal Stem cells secretory responses: senescence messaging secretome and immunomodulation perspective
- Identification of Stem cells in the epithelium of the stomach corpus and antrum of mice
- Epigenetic and microenvironmental alterations in bone marrow associated with ROS in experimental aplastic anemia
- Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side
- Human iPSC Models to Study Orphan Diseases: Muscular Dystrophies
- Heart-breaking telomeres
- Tumor-derived cytokines impair myogenesis and alter the skeletal muscle immune microenvironment
- “Known unknowns”: Current questions in muscle satellite cell biology
- Lung diseases of the elderly: cellular mechanisms
- Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions
- Sarcopenia and aging
- NAD+ in aging: molecular mechanisms and translational implications
- Pre-transplantation blockade of TNF-α-mediated oxygen species accumulation protects hematopoietic Stem cells
- I. Revue 1: Role of EZH2 in normal hematopoiesis and hematologic malignancies
- Trauma and transfusion in the geriatric patient
- cell -extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells
- The aging mitochondria
- Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a
- Protective effects of alpha phenyl-tert-butyl nitrone and ascorbic acid in human adipose derived mesenchymal Stem cells from differently aged donors
- Paternal sepsis induces alterations of the sperm methylome and dampens offspring immune responses—an animal study
- ESRD-associated immune phenotype depends on dialysis modality and iron status: clinical implications
- Physical exercise rescues defective neural Stem cells and neurogenesis in the adult subventricular zone of Btg1 knockout mice
- Polycomb repressive complexes in hematological malignancies
- Nfix Promotes Survival of Immature Hematopoietic Cells via Regulation of c-Mpl
- Concise review: getting to the core of inherited bone marrow failures
- Substrate topography modulates cell aging on a progeria cell model
- Wnt pathway activator TWS119 enhances the proliferation and cytolytic activity of human γδT cells against colon cancer
- The H3K4 methyltransferase Setd1b is essential for hematopoietic Stem and progenitor cell homeostasis in mice
- High-dimensional phenotyping identifies age-emergent cells in human mammary epithelia
- Investigating The Role Of Signaling Pathways In Adult Stem Cells Governed By Population Asymmetry
- Type I IFNs drive hematopoietic Stem and progenitor cell collapse via impaired proliferation and increased RIPK1-dependent cell death during shock-like …
- Nucleolar expansion and elevated protein translation in premature aging
- Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging
- An analysis of gene expression data involving examination of signaling pathways activation reveals new insights into the mechanism of action of minoxidil topical …
- Aging in the cardiovascular syStem: lessons from Hutchinson-Gilford progeria syndrome
- Epithelial to mesenchymal transition-related proteins ZEB1, β-catenin, and β-tubulin-III in idiopathic pulmonary fibrosis
- Humanizing the mdx mouse model of DMD: the long and the short of it
- Long-term selection of chickens for body weight alters muscle satellite cell behaviors
- Licence to kill senescent cells in idiopathic pulmonary fibrosis?
- Differential regulation of spermatogenic process by Lkb1 isoforms in mouse testis
- Radical life extension, cybernetic immortality, and techno‐salvation. Really?
- Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders
- Programmed cell senescence in skeleton during late puberty
- Sarcopenia, aging and prospective interventional strategies
- Therapeutic interventions for aging: the case of cellular senescence
- Dietary polyphenols and neurogenesis: Molecular interactions and implication for brain ageing and cognition
- PTEN is fundamental for elimination of leukemia Stem cells mediated by GSK126 targeting EZH2 in chronic myelogenous leukemia
- Potential mechanisms of age acceleration caused by estrogen deprivation: do endocrine therapies carry the same risks?
- The association between obstructive sleep apnea and shortened telomere length: a syStematic review and meta-analysis
- Mechanisms of cancer resistance in long-lived mammals
- Constitutively active ABL family kinases, TEL/ABL and TEL/ARG, harbor distinct leukemogenic activities in vivo
- Management of chronic lymphocytic leukemia (CLL) in the elderly: a position paper from an international Society of Geriatric Oncology (SIOG) Task Force
- Basic characteristics of muse cells
- SIRT1 regulates macrophage self‐renewal
- Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations
- Assessment of the anti-aging klotho protein in patients with COPD undergoing pulmonary rehabilitation
- Emerging roles for sphingolipids in cellular aging
- The Hippo pathway in normal development and cancer
- Aryl hydrocarbon receptor inhibition promotes hematolymphoid development from human pluripotent Stem cells
- Targeting the Cellular Redox Environment: A Novel Approach for the Treatment of Hematopoietic Neoplasms
- Quiescent Oct4+ Neural Stem Cells (NSCs) Repopulate Ablated Glial Fibrillary Acidic Protein+ NSCs in the Adult Mouse Brain
- Biomedical Research in Aging
- Novel role of the SIRT4-OPA1 axis in mitochondrial quality control
- Invertebrates as model organisms for research on aging biology
- The intersection of aging biology and the pathobiology of lung diseases: a joint NHLBI/NIA workshop
- Translational geroscience: A new paradigm for 21st century medicine
- Genetic and tissue engineering approaches to modeling the mechanics of human heart failure for drug discovery
- SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy
- Aging metabolism: intervention strategies
- Modeling neuropsychiatric and neurodegenerative diseases with induced pluripotent Stem cells
- Hair regeneration by small molecules that activate autophagy
- Starvation signals in yeast are integrated to coordinate metabolic reprogramming and stress response to ensure longevity
- Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis
- Aging and anti-aging: a combo-endocrinology overview
- Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence
- Chiara Zagni, Luciana O. Almeida, Tarek Balan, 3 Marco T. Martins, Luciana K. Rosselli-Murai
- Pancytopenia: A Challenging Problem for Treating Physician
- Interleukin-7 and immunosenescence
- Role of miR-200c in myogenic differentiation impairment via p66Shc: implication in skeletal muscle regeneration of dystrophic mdx mice
- DNA methylation-based age prediction from various tissues and body fluids
- Foxp1 is indispensable for ductal morphogenesis and controls the exit of mammary Stem cells from quiescence
- Elixir of life: thwarting aging with regenerative reprogramming
- Synthetic matrix enhances transplanted satellite cell engraftment in dystrophic and aged skeletal muscle with comorbid trauma
- Immobilised growth factors for scalable cell therapy manufacturing platforms
- Targeting aging for disease modification in osteoarthritis
- Cellular senescence: a view throughout organismal life
- Flagellin-Mediated Irradiation Protection in Mice
- From lymphopoiesis to plasma cells differentiation, the age-related modifications of B cell compartment are influenced by “inflamm-ageing”
- Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy
- Epithelial autophagy and longevity of Hydra oligactis, a new model for aging research
- The role of epigenetics in renal ageing
- Physiology of ageing of the musculoskeletal syStem
- EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms
- Splicing regulatory factors, ageing and age-related disease
- Decreased telomere length in children with cartilage-hair hypoplasia
- Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response
- Emerging Connections: Synaptic Autophagy in Brain Aging and Disease
- Attenuation of PKC δ enhances metabolic activity and promotes expansion of blood progenitors
- Hair growth stimulation by a natural remedy: Animal studies
- RUNX1 mutations in inherited and sporadic leukemia
- Gene expression signature of the ageing lung: breathing new life into COPD
- A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells
- Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis
- Mitochondrial quality control mechanisms as molecular targets in cardiac ageing
- Pulmonary fibrosis, part I: epidemiology, pathogenesis, and diagnosis
- Molecular regulation of hair follicle Stem and progenitor cell homeostasis
- MicroRNA-146a induces lineage-negative bone marrow cell apoptosis and senescence by targeting polo-like kinase 2 expression
- DAF-16/FOXO transcription factor in aging and longevity
- Skeletal muscle regenerative potential of human MuStem cells following transplantation into injured mice muscle
- The molecular intersection between senescence and major depression in the elderly
- Collagenase impacts the quantity and quality of native mesenchymal Stem/stromal cells derived during processing of umbilical cord tissue
- Current advances and limitations in modeling ALS/FTD in a dish using induced pluripotent Stem cells
- Relevance of the p53–MDM2 axis to aging
- MMR deficiency does not sensitize or compromise the function of hematopoietic Stem cells to low and high LET radiation
- Sox2 and Meis1 in tooth development and murine incisor renewal
- Heme oxygenase-1 influences satellite cells and progression of Duchenne muscular dystrophy in mice
- Horizons in the evolution of aging
- Recent advances in lung regeneration
- A mouse model for evaluation of efficacy and concomitant toxicity of anti-human CXCR4 therapeutics
- The aging population with HIV infection
- Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo
- Oral health in geroscience: animal models and the aging oral cavity
- Epigenetic modifications in cardiovascular aging and diseases
- How might transbronchial cryobiopsy improve diagnosis and treatment of diffuse parenchymal lung disease patients?
- Targeting senescence to delay progression of multiple sclerosis
- Rejuvenation of cardiac tissue developed from reprogrammed aged somatic cells
- Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle
- Oncological challenges for an ageing population living with HIV
- Adaptive NK cells can persist in patients with GATA2 mutation depleted of Stem and progenitor cells
- Making gene editing a therapeutic reality [version 1; peer review
- Emerging molecular pathways governing dietary regulation of neural Stem cells during aging
- Insights into the pathogenic secondary symptoms caused by the primary loss of dystrophin
- Opportunities for organoids as new models of aging
- RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia
- Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells
- Satellite cells maintain regenerative capacity but fail to repair disease-associated muscle damage in mice with Pompe disease
- Characterizing a Signaling Network That Maintains Hematopoietic Stem Cells
- Pediatric leukemia susceptibility disorders: manifestations and management
- Genetic regulation of the RUNX transcription factor family has antitumor effects
- JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML
- Making gene editing a therapeutic reality
- Methods of reactivation and reprogramming of neural Stem cells for neural repair
- NAD+ deficits in age-related diseases and cancer
- Dkk3 dependent transcriptional regulation controls age related skeletal muscle atrophy
- Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases
- RNA processing in the male germline: mechanisms and implications for fertility
- Inflammation, a significant player of Ataxia–Telangiectasia pathogenesis?
- Parabiosis and Aging Researches
- Basic science and pathogenesis of ageing with HIV: potential mechanisms and biomarkers
- Biological/pathological functions of the CXCL12/CXCR4/CXCR7 axes in the pathogenesis of bladder cancer
- Sepsis induces a long-lasting state of trained immunity in bone marrow monocytes
- Ataxia telangiectasia mutated kinase is an autophagic balancer at the onset of heart failure
- Loss of SIRT 2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance
- Aryl hydrocarbon receptor (AhR) ligands as selective AhR modulators: Genomic studies
- HOXB13 mutations and binding partners in prostate development and cancer: Function, clinical significance, and future directions
- Genetics of Progeria and Aging
- Evaluation of EZH2 expression in hepatitis B patients
- Double sword role of EZH2 in leukemia
- mTOR cross-talk in cancer and potential for combination therapy
- The impact of cellular senescence in skin ageing: a notion of mosaic and therapeutic strategies
- Is chronic kidney disease-mineral and bone disorder associated with the presence of endothelial progenitor cells with a calcifying phenotype?
- PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing
- The integration of inflammaging in age-related diseases
- The energy maintenance theory of aging: maintaining energy metabolism to allow longevity
- Inflammatory cytokines and comorbidity development in breast cancer survivors versus noncancer controls: evidence for accelerated aging?
- Novel biallelic missense mutations in CTC1 gene identified in a Chinese family with Coats plus syndrome
- The continuum of aging and age-related diseases: common mechanisms but different rates
- Therapeutic potential of boosting NAD+ in aging and age-related diseases
- Ayurveda and the science of aging
- DICER1: A Key Player in rheumatoid arthritis, at the crossroads of cellular stress, innate immunity, and chronic inflammation in aging
- Dysregulation of mesenchymal stromal cell antioxidant responses in progressive multiple sclerosis
- The transcription factor Zfx regulates peripheral T cell self-renewal and proliferation
- Mitochondria, its DNA and telomeres in ageing and human population
- Age‐related small vessel disease: a potential contributor to neurodegeneration in multiple sclerosis
- Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy
- Targeting primary acute myeloid leukemia with a new CXCR4 antagonist IgG1 antibody (PF
- Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
- Nutritional regulation of intestinal Stem cells
- Targeting histone methylation in cancer
- Understanding lamin proteins and their roles in aging and cardiovascular diseases
- Role of endogenous glucocorticoids in cancer in the elderly
- A novel stilbene-like compound that inhibits melanoma growth by regulating melanocyte differentiation and proliferation
- Sirt1 and Parp1 as epigenome safeguards and microRNAs as SASP-associated signals, in cellular senescence and aging
- Distinct roles of Wnt/β-catenin signaling in the pathogenesis of chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis
- Idiopathic pulmonary fibrosis
- Causes of pulmonary fibrosis in the elderly
- Sirtuins and accelerated aging in scleroderma
- The mechanism of B cell acute lymphoblastic leukemia development
- Aging of Human Mesenchymal Stem Cells
- Incorporation of macrophages into engineered skeletal muscle enables enhanced muscle regeneration
- Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention
- Therapeutic Gene Editing in Muscles and Muscle Stem Cells
- Drosophila as a model for ageing
- Biphasic modeling of mitochondrial metabolism dysregulation during aging
- Xenohormesis in early life: New avenues of research to explore anti-aging strategies through the maternal diet
- Let-7 suppresses B cell activation through restricting the availability of necessary nutrients
- Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance
- Histone Variant MacroH2A in the Gut and Beyond: A Study of Intestinal Fortitude
- Updates from the TP53 universe
- Probiotic bacteria for healthier aging: immunomodulation and metabolism of phytoestrogens
- Interrelationship of canonical and non-canonical Wnt signalling pathways in chronic metabolic diseases
- States of G0 and the proliferation-quiescence decision in cells, tissues and during development
- COPD in the elderly: The ageing lung
- Short telomeres—a hallmark of heritable cardiomyopathies
- Steroidogenesis decline accompanied with reduced antioxidation and endoplasmic reticulum stress in mice testes during ageing
- The African turquoise killifish: A research organism to study vertebrate aging and diapause
- C/EBPβ is required for survival of Ly6C− monocytes
- A novel functional in vitro model that recapitulates human muscle disorders
- Immortality Research Literatures
- Mechanisms and consequences of oxidative stress in lung disease: therapeutic implications for an aging populace
- Articular cartilage repair of the knee in children and adolescents
- PPAR-delta promotes survival of chronic lymphocytic leukemia cells in energetically unfavorable conditions
- B-cell PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA CELLS MANIPULATE MESENCHYMAL STROMAL CELLS
- A regulatory role for RUNX1, RUNX3 in the maintenance of genomic integrity
- Senescent cells and osteoarthritis: a painful connection
- Cutaneous infections in the mature patient
- Searching for a Cancer-Proof Organism: It’s the Journey That Teaches You About the Destination
- Nintedanib decreases muscle fibrosis and improves muscle function in a murine model of dystrophinopathy
- Generation of induced progenitor-like (iPL) cells using interrupted reprogramming
- Olive oil and skin anti-aging.
- Transcriptional selectivity of epigenetic therapy in cancer
- Ubiquitination by HUWE1 in tumorigenesis and beyond
- Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
- Biological Determinants of Men’s Health and Aging
- Aeroaging—A new collaboration between life sciences experts and aerospace engineers
- Emerging candidate treatment strategies for Hutchinson-Gilford progeria syndrome
- Emerging roles of CST in maintaining genome stability and human disease
- A virus-acquired host cytokine controls syStemic aging by antagonizing apoptosis
- EVI1 carboxy-terminal phosphorylation is ATM-mediated and sustains transcriptional modulation and self-renewal via enhanced CtBP1 association
- Ageing, cellular senescence and neurodegenerative disease
- Aging across the tree of life: The importance of a comparative perspective for the use of animal models in aging
- Resilient protein co-expression network in male orbitofrontal cortex layer 2/3 during human aging
- Exosomes as mediators of the syStemic adaptations to endurance exercise
- Probing the pathogenesis of Duchenne muscular dystrophy using mouse models
- Basic biology of oxidative stress and the cardiovascular syStem: part 1 of a 3-part series
- Sex differences in aging: genomic instability
- Functional genomics approaches to characterize the role of polycomb group genes in hematopoiesis
- Biological predictors of aging and potential of FTIR to study age-related diseases and aging metabolic fingerprint
- Ageing and ocular surface immunity
- Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence
- α-Synuclein pathology and mitochondrial dysfunction
- Turning round: optimizing the anti-inflammatory properties of equine bone marrow derived mesenchymal Stem cells for osteoarthritis through three-dimensional culture
- Autophagy and the cell cycle: a complex landscape
- Application of biological age assessment of Chinese population in potential anti-ageing technology
- Myeloid Translocation Gene 16 as a Determinant of Notch-driven Leukemic Phenotype
- The role of telomeres in the mechanisms and evolution of life-history trade-offs and ageing
- A reduction in DNA damage in neural tissue and peripheral blood of old mice treated with caffeine
- Mitohormesis, an antiaging paradigm
- Effects of physiological overexpression of SIRT6 in metabolism and cancer
- Molecular Interaction Between the Microenvironment and FLT3/ITD+ AML Cells Leading to the Refractory Phenotype
- BBA-Molecular Basis of Disease
- cell cycle RNA regulons coordinating early lymphocyte development
- Screening of exosomal miRNAs derived from subcutaneous and visceral adipose tissues: determination of targets for the treatment of obesity and associated …
- Establishment of photoaging in vitro by repetitive UVA irradiation: Induction of characteristic markers of senescence and its prevention by PAPLAL with potent catalase …
- GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis
- Transcriptomic network analysis of brain aging and alzheimers disease
- Dynamical analysis of cellular ageing by modeling of gene regulatory network based attractor landscape
- 53BP1–RIF1–shieldin counteracts DSB resection through CST-and Polα-dependent fill-in
- Regulation of Programmed Necrosis and Bone Marrow Failure
- DNA and Histone Modifications in Cancer Therapy
- Idiopathic pulmonary fibrosis: aging, mitochondrial dysfunction, and cellular bioenergetics
- Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells
- Back to the future: epigenetic clock plasticity towards healthy aging
- The CST complex mediates end protection at double-strand breaks and promotes PARP inhibitor sensitivity in BRCA1-deficient cells
- Age-Related Variations in Gene Expression Patterns of Renal cell Carcinoma: Biological and Translational Implications
- Report: NIA workshop on measures of physiologic resiliencies in human aging
- The advances and challenges of gene therapy for Duchenne muscular dystrophy
- The role of COUP-TFII in striated muscle development and disease
- Use of zebrafish to study Shigella infection
- Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks
- Hallmarks of brain aging: adaptive and pathological modification by metabolic states
- Transcriptional regulation of human paraoxonase 1 by nuclear receptors
- The effect of Poly I: C induced inflammation on hematopoietic Stem and progenitor cell behaviour in the zebrafish hematopoietic transplant model
- CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells
- Retinal, NPY-and 5 ht-inputs to the aged suprachiasmatic nucleus in common marmosets (Callithrix jacchus)
- Emerging molecular predictive and prognostic factors in acute myeloid leukemia
- Lung tissue gene-expression signature for the ageing lung in COPD
- Redox theory of aging: implications for health and disease
- Recent advances in targeting protein arginine methyltransferase enzymes in cancer therapy
- mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation
- Idiopathic pulmonary fibrosis: pathogenesis and management
- Does ageing foster transformation to Acute Myeloid Leukaemia? Study of mice cohort bearing haematopoietic malignancy burden, and the effects of ageing on …
- Conservation of a gene expression barcode that defines spermatogonial Stem cells in mice and humans
- Expression profiling of mRNAs and long non-coding RNAs in aged mouse olfactory bulb
- Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?
- Regulation of cell proliferation and differentiation by p38 MAPK in distinct physiopathological processes
- Epigenetic biomarkers for biological age
- Wnt signaling in bone metastasis: mechanisms and therapeutic opportunities
- Telomeres and Cardiovascular Diseases
- Low serum tryptophan levels as an indicator of global cognitive performance in nondemented women over 50 years of age
- Deletion of mitochondrial inorganic pyrophosphatase gene extends life span in haploid yeast (Saccharomyces cerevisiae)
- The epigenetic regulation of telomere maintenance in aging
- STAT5BN642H is a driver mutation for T cell neoplasia
- Physiological roles of the DNA demethylation-associated proteins Gadd45a and Ing1
- The geometric framework: An approach for studying the impact of nutrition on healthy aging
- Cycles of myofiber degeneration and regeneration lead to remodeling of the neuromuscular junction in two mammalian models of Duchenne muscular …
- Unravelling the identity and fate of Notch1-expressing cells within intestinal tumours
- Dual Roles of Fer Kinase Are Required for Proper Hematopoiesis and Vascular Endothelium Organization during Zebrafish Development
- Autophagy and proteostasis in the control of synapse aging and disease
- Oxidative and nitrosative stress in myeloproliferative neo-plasms: The impact on the AKT/mTOR signaling pathway
- Physiological and Pathological Vascular Aging
- Whole-body clearing, staining and screening of calcium deposits in the mdx mouse model of Duchenne muscular dystrophy
- Comprehensive geriatric assessment: an updated perspective
- EVI5 is a novel independent prognostic predictor in hepatocellular carcinoma after radical hepatectomy
- Computational methods for developing novel antiaging interventions
- The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells
- The importance of biophysical and biochemical stimuli in dynamic skeletal muscle models
- Aging-associated Changes in the DNA Methylome and Characteristics of the Epigenetic Clock
- Chronic Obstructive Pulmonary Disease (COPD) as a disease of early aging: Evidence from the EpiChron Cohort
- The quest for osteoporosis mechanisms and rational therapies: how far we’ve come, how much further we need to go
- The Epithelial To Mesenchymal Transition In Breast Cancer Induces Alterations In Metabolism
- Aging in a relativistic biological space-time
- Translational Medicine of Aging
- HIV/AIDS: oxidative stress and dietary antioxidants
- Improvement of dystrophic muscle fragility by short-term voluntary exercise through activation of calcineurin pathway in mdx mice
- Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation
- RISKS OF BLOOD-BORNE
- Development of a Duchenne Muscular Dystrophy Registry in South Africa to optimise care
- Studies on the Mechanisms of DNA Damage Repair in Human Neurons
- Cardiovascular Aging Compendium
- Dual roles of fer kinase are required for proper hematopoiesis and vascular endothelium organization during zebrafish development
- Ex Vivo Expansion of Skeletal Muscle Stem Cells with a Novel Inhibitor of eIF1α Dephosphorylation
- Primary scalp alopecia: new histopathological tools, new concepts and a practical guide to diagnosis
- FOXOs maintaining the equilibrium for better or for worse
- Interleukin-6 affects aging-related changes of the pparα-PGC-1α axis in the myocardium
- RPL5 on 1p22. 1 is recurrently deleted in multiple myeloma and its expression is linked to bortezomib response
- A high-throughput screening syStem to identify modulators of cancer Stem cells and improve chemotherapy sensitization
- The potential of comparative biology to reveal mechanisms of aging in rotifers
- Current perspective in the discovery of anti-aging agents from natural products
- Brain aging: Hsp90 and neurodegenerative diseases
- Stat3 and CCAAT enhancer–binding protein β (C/ebpβ) activate Fanconi C gene transcription during emergency granulopoiesis
- Hormetic induction of antioxidant defenses for promotion of healthy aging
- The role of the protein SNEVhPrp19/hPso4 in function and morphology of human dermal fibroblasts and human epidermal keratinocytes
- Comparison of primary human gingival fibroblasts from an older and a young donor on the evaluation of cytotoxicity of denture adhesives
- Age-Associated Changes in Structure and Function of the Aging Human Lung
- The impact of substance use disorders on clinical outcomes in older‐adult psychiatric inpatients
- DEPTOR at the nexus of cancer, metabolism, and immunity
- Transcriptome network analysis reveals aging-related mitochondrial and proteasomal dysfunction and immune activation in human thyroid
- Restoring effects of natural anti-oxidant quercetin on cellular senescent human dermal fibroblasts
- Using comparative biology to understand how aging affects mitochondrial metabolism
- Physical activity and nutrition: two promising strategies for telomere maintenance?
- der Mathematisch-Naturwissenschaftlichen Fakultät der Eberhard Karls Universität Tübingen zur Erlangung des Grades eines Doktors der Naturwissenschaften …
- Dissecting host cell death programs in the pathogenesis of influenza
- Characterisation of Newt Neural Stem Cells During Development and Regeneration
- ICEC0942, an orally bioavailable selective inhibitor of CDK7 for cancer treatment
- Targeting cell Cycle Proteins in Brain Cancer
- An Analysis of the effects of Mocs1 upregulation on lifespan in Drosophila melanogaster
- Pulmonary Diseases, a Matter of Time
- MMP2-A2M interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction
- RUNX1 cooperates with FLT3-ITD to induce leukemia
- mTORC1 loss impairs epidermal adhesion via TGF-b/Rho kinase activation
- Ageing and Neurologic Disease
- Recent insights into the cellular and molecular determinants of aging
- The mitochondria in lung fibrosis: friend or foe?
- Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging
- Human CST prefers G-Rich but not necessarily telomeric sequences
- Recombinant latcripin 11 of Lentinula edodes C91-3 suppresses the proliferation of various cancer cells
- Translational geroscience: from invertebrate models to companion animal and human interventions
- IDENTIFICATION OF INTRINSIC REGULATORS IN NORMAL AND MALIGNANT HUMAN HEMATOPOIESIS
- Ataxia telangiectasia syndrome: moonlighting ATM
- Differential gene expression of a feed-spiked super-producing CHO cell line
- Toll-like receptor-4 signaling pathway in aorta aging and diseases:“its double nature”
- Natural variations in yeast aging reveal genetic and environmental factors
- Sequential phosphorylation of CST subunits by different cyclin-Cdk1 complexes orchestrate telomere replication
- Modelling the molecular mechanisms of aging
- 37 kDa LRP:: FLAG enhances telomerase activity and reduces senescent markers in vitro
- Periodontology for Geriatric Patients
- The companion dog as a unique translational model for aging
- Hematopoietic cell Engineering from Human Pluripotent Stem Cells
- Changing the pathobiological paradigm in myelodysplastic syndromes: The NLRP3 inflammasome drives the MDS phenotype
- Chronic obstructive pulmonary disease in elderly patients
- Serine catabolism by SHMT2 is required for proper mitochondrial translation initiation and maintenance of formylmethionyl-tRNAs
- Mitochondrial-targeted catalase: extended longevity and the roles in various disease models
- The Role of Epigenetics
- Aging as an epigenetic phenomenon
- Common and unique transcriptional responses to dietary restriction and loss of insulin receptor substrate 1 (IRS1) in mice
- Improved immune responses in young and aged mice with adjuvanted vaccines against H1N1 influenza infection
- The decay of redox-stress response capacity is a substantive characteristic of aging: revising the redox theory of aging
- Hormones in clock regulation during ageing
- Dictyostelium discoideum: A Model SyStem to Study Autophagy Mediated Life Extension
- The mitochondrial basis of aging and age-related disorders
- Novel treatment strategies for chronic kidney disease: insights from the animal kingdom
- Effects of Cranial Irradiation on Adult Hippocampal Neuronal Development and the Role of p53
- A null mutation in SERPINE1 protects against biological aging in humans
- Hepatic potential of Reversed-age Mesenchymal Stem Cells and Endodermal Progenitors: Contribution of LGR5 and Cdc42 cell signaling pathways
- Major trauma and acceleration of the ageing process
- Inhibitory effect of naringenin on LPS-induced skin senescence by SIRT1 regulation in HDFs
- Cellular metabolism and oxidative stress as a possible determinant for longevity in small breed and large breed dogs
- Aging Pathology in Sprague Dawley Rats: Background Lesions and Comparative Study Between Wild Type and Transgenic Rats with Neuronal Overexpression of …
- The Regulation of Telomerase Reverse Transcriptase (TERT) by CCAAT/Enhancer Binding Protein β (C/EBPβ) During Skeletal Muscle Differentiation
- Exposure to Concentrated Ambient PM2.5 Shortens Lifespan and Induces Inflammation-Associated Signaling and Oxidative Stress in Drosophila
- Exploring the mechanistic effects of life extending treatments on the mTOR network: a combined computational and experimental approach
- The Role of Secreted Frizzled-related Protein-4 (sFRP4) in the Epigenetics, Metabolism and Chemo-sensitisation of Cancer Stem Cells
- Does dietary nitrate say NO to cardiovascular ageing? Current evidence and implications for research
- The contribution of oxidative stress and inflamm-aging in human and equine asthma
- Unraveling novel genes that are essential for acute myeloid leukemia and normal hematopoiesis
- Targeting aging and Alzheimer’s disease: from GM1 ganglioside to amyloide-β peptide
- Effects of resveratrol and other polyphenols on Sirt1: relevance to brain function during aging
- The role of free radicals in autophagy regulation: implications for ageing
- The role of endocannabinoid syStem in neuron-glial communication in the ageing and diseased brain
- Current Perspective in the Discovery of Anti-aging Agents from Natural Products
- When nature’s robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies
- Age-associated inflammation impairs myeloid development and monocyte and macrophage function
- The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature
- The Cellular And Molecular Underpinnings Of Intestinal Epithelial Regeneration
- Identification of LRP8, CDCA7, and MLK4 as Novel Therapeutic Targets for Cancer Stem Cells in Triple-Negative Breast Cancer
- Aging kidney and aging-related disease
- Stage-specific changes in the Krebs cycle network regulate human erythroid differentiation
- Targeting mitochondria to counteract age-related cellular dysfunction
- Parallels in immunometabolic adipose tissue dysfunction with ageing and obesity
- Mitochondrial activity and dynamics changes regarding metabolism in ageing and obesity
- Insights into mortality patterns and causes of death through a process point of view model
- The chromatin accessibility signature of aging in human blood leukocytes Stem from CD8+ T cells.
- CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance
- Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function
- Pathogenic CTC1 mutations cause global genome instabilities under replication stress
- Autophagy in age-associated neurodegeneration
- DNA Damage-related Vascular Dysfunction: Pathways and Interventions
- DNA replication origins and fork progression at mammalian telomeres
- Chronic obstructive pulmonary disease with mild airflow limitation: current knowledge and proposal for future research–a consensus document from six …
- DNA methylation–based measures of biological aging
- Characterizing the Role of the E3 Ligase ITCH in Gut Mucosal Homeostasis
- Holothuria scabra extracts possess anti-oxidant activity and promote stress resistance and lifespan extension in Caenorhabditis elegans
- Functional Identification of MicroRNAs Counteracting Cellular Senescence
- Healthy at 100: Genetic factors and phenotypes associated with healthy aging and longevity
- Senescence Induced by DNA Demethylating Drugs to Treat Solid Tumors
- Protein posttranslational modifications: roles in aging and age-related disease
- Pathogenesis of COPD 4–cell Death, Senescence, and Autophagy: Is There a Possibility of Developing New Drugs from the Standpoint of This Pathogenetic …
- Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism
- The Potential Detrimental Impact of Galactic Cosmic Radiation on Central Nervous SyStem and Hematopoietic Stem Cells
- Identification of affected pro-atherogenic gene targets in Prog-Tg mice and endothelial cells
- Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts
- Onset and progression of human osteoarthritis—Can growth factors, inflammatory cytokines, or differential miRNA expression concomitantly induce proliferation, ECM …
- The therapeutic potential of metformin in neurodegenerative diseases
- Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans
- Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes
- Exploring the biochemistry of the prenylome and its role in disease through proteomics: progress and potential
- Cognitive impairment in chronic obstructive pulmonary disease (COPD): Possible utility of marine bioactive compounds
- Mitotic chromosome alignment is required for proper nuclear envelope reassembly
- The role of P53 signaling pathway in aging and cancer
- MicroRNAs and the metabolic hallmarks of aging
- Analysis of phenotype reversibility in Hutchinson-Gilford progeria syndrome in mice
- Ophthalmologic features of Hutchinson-Gilford Progeria syndrome
- Role of autophagy in normal and malignant hematopoiesis
- Remodeling of the extracellular matrix in COPD. a process of accelerated lung ageing?
- Novel targets for delaying aging: the importance of the liver and advances in drug delivery
- JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21
- STUDY OF OXIDATIVE STRESS AND ANTIOXIDANT RESPONSE IN THE SGCA NULL DYSTROPHIC MOUSE MODEL
- The fission yeast Stn1-Ten1 complex limits telomerase activity via its SUMO-interacting motif and promotes telomeres replication
- Alterations in Autophagy and Senescence in the Pathologically Aged Uraemic Heart
- Healthy human aging: intrinsic and environmental factors
- The role of melanocyte senescence in skin ageing
- ZBTB 48 is both a vertebrate telomere‐binding protein and a transcriptional activator
- Role of inflammation and oxidative stress in the pathology of ageing in COPD: potential therapeutic interventions
- Membrane Lipid Replacement for chronic illnesses, aging and cancer using oral glycerolphospholipid formulations with fructooligosaccharides to restore …
- RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions
- Interrelation of mitochondrial DNA and telomere length alterations in ageing human population
- CRISPR-Cas9 mutagenesis of the zebrafish foxm1
- Host-Pathogen Interactions at the Intestinal Epithelial Barrier
- Effects of resveratrol and other polyphenols on the most common brain age-related diseases
- Targeting the antagonism of AHR by MSI2 as a novel anti-leukemic strategy in human acute myeloid leukemia
- Phosphorylation dependent structural function of DNA-PKcs in DNA repair and hematopoiesis
- Transdifferentiation in Turritopsis dohrnii (Immortal Jellyfish): Model SyStem for Regeneration, Cellular Plasticity and Aging
- Regulation and Consequences of Retrotransposition During Quiescence in Budding Yeast
- DNA damage and oxidative stress in long-lived aquatic organisms
- Modeling Tuberous Sclerosis Complex Using Patient-Derived Cells
- Telomere dynamics and cellular senescence: an emerging field in environmental and occupational toxicology
- Investigating the Role of the Chromatin Factor SIRT6 in Metabolism of Squamous cell Carcinoma
- Rodak’s hematology: clinical principles and applications
- Characterization of epigenetic and transcriptional changes in aging and Alzheimer’s disease
- Circadian Mechanisms of Calorie Restriction in Delaying Aging
- Delineating Transcriptional and Epigenetic Regulations in Normal and Ageing Spermatogonial Stem Cells
- Quantitative telomeric chromatin isolation protocol for human cells
- Epigenetics and aging research: Between adult malleability and early life programming
- STN1–POLA2 interaction provides a basis for primase-pol α stimulation by human STN1
- Autophagy and microglia: novel partners in neurodegeneration and aging
- Circulating levels of soluble Receptor for Advanced Glycation End-products (sRAGE) decrease with aging and may predict age-related cardiac remodeling
- Correlation Between Epstein-Barr Virus Infection and The Severity of Malaria in Ghanaian Children Under Five (5) Years of Age
- Human life extension: opportunities, challenges, and implications for public health policy
- Zebrafish aging models and possible interventions
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- The early events that initiate β-amyloid aggregation in Alzheimer’s disease
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- PGC-1α in neurodegeneration and ageing
- Adult neurogenesis in a diurnal vertebrate: from hours to years
- Effects of Novel Aging-Delaying Plant Extracts on the Lipid Composition of the Yeast Saccharomyces Cerevisiae
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- Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs
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- Effect of novel ryanodine receptor modulators in mouse and human models of Duchenne muscular dystrophy
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- Store-operated calcium entry in adult mice ventricular cardiomyocytes
- The hepatic fate of vitamin E
- Glycogen regulates cellular proliferation in the context of aging, tumorigenesis, and hepatic regeneration
- When evolution is the solution to pollution: Key principles, and lessons from rapid repeated
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- The Role of Homeobox Transcription Cofactors in Prostate Development and Tumor Growth
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- Intervertebral Disc Inflammation: The Effect Of Il-1ra Deficiency On Development, Aging And Injury Of The Murine Caudal Intervertebral Disc
- Medication, Exercise and Quality of Life in Older Adults
- Role of NLRP3-inflammasone in functional decline in physiological aging. Implications for cardio-metabolic events.
- Longevity, aging and DNA damage: investigation of the role of 53BP1 in the maintenance of genomic stability
- Ageing, inorganic nitrate and vitamin C: effects on markers of cardiovascular risk
- Neurochemical aspects of Alzheimer’s disease: risk factors, pathogenesis, biomarkers, and potential treatment strategies
- The effect of age on brain insulin signalling
- Dietary patterns and whole plant foods in aging and disease
- Telomeric double strand breaks undergo resection-but not repair-in G1 human cells
- Aging and microRNA messaging: associations with syStemic estrogen levels and physical performance
- Development and application of RNA-seq bioinformatic tools to explore non-model organisms in ageing research
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- Immunomodulation by raw bovine milk and its ingredients: effects in nutritional intervention, oral vaccination and trained immunity
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- The BARD1 BRCT Domain in Tumor Suppression and Genome Stability
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- Vascular regenerative cell exhaustion in diabetes: translational opportunities to mitigate cardiometabolic risk
- Disruption of the Normal Hematopoietic Hierarchy Leading to Stem cell exhaustion in an Animal Model of Myelodysplastic Syndrome
- Adult Stem cell deficits drive Slc29a3 disorders in mice
- Telomere shortening as a hallmark of Stem cell senescence
- Zika virus and the metabolism of neuronal cells
- The epigenetics of Stem cell aging comes of age
- Adult cardiac Stem cell aging: a reversible stochastic phenomenon?
- Advances in Stem cell Research in Sepsis 17
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- Advances in Stem cell Research in Sepsis
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- Role of hypothalamus in aging and its underlying cellular mechanisms
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- Application of mtor inhibitors in extending longevity
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- Phase I/II study of Stem–cell transplantation using a single cord blood unit expanded ex vivo with nicotinamide
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- Hematopoietic Stem cell heterogeneity
- Investigating Neural Stem cell Function in an Alzheimer’s Disease Model
- Juel Rasmussen Group
- The NAD-booster nicotinamide riboside potently stimulates hematopoiesis through increased mitochondrial clearance
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- Senolytics and senostatics: a two-pronged approach to target cellular senescence for delaying aging and age-related diseases
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- A Stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia Stem cell latency
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- Redox regulation by NRF2 in aging and disease
- Divide and conquer: two Stem cell populations in squamous epithelia, reserves and the active duty forces
- Idiopathic Pulmonary Fibrosis
- Decelerating ageing and biological clocks by autophagy
- Novel approaches targeting mitochondrial fission to deplete Stem-like tumor cells in prostate cancer and improve treatment outcomes
- Loss of postnatal quiescence of neural Stem cells through mTOR activation upon genetic removal of cysteine string protein-α
- The aging thyroid: a reappraisal within the geroscience integrated perspective
- Molecular regulation of spermatogonial Stem cell renewal and differentiation
- SIRT1 is dispensable for maturation of hematopoietic Stem cell in the bone marrow niche
- Stem cell competition orchestrates skin homeostasis and ageing
- Transient non-integrative nuclear reprogramming promotes multifaceted reversal of aging in human cells
- Pluripotent Stem Cells for Gene Therapy of Hereditary Muscle Disorders
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- Epigenetic control of mitochondrial fission enables self-renewal of Stem-like tumor cells in human prostate cancer
- Ptpn21 controls hematopoietic Stem cell homeostasis and biomechanics
- Polycomb/trithorax antagonism: cellular memory in Stem cell fate and function
- Studying Werner syndrome to elucidate mechanisms and therapeutics of human aging and age-related diseases
- Skeletal muscle Stem cell self-renewal and differentiation kinetics revealed by EdU lineage tracing during regeneration
- Flavonoids and reduction of cardiovascular disease (CVD) in chronic obstructive pulmonary disease (COPD)
- CABLES1 deficiency impairs quiescence and stress responses of hematopoietic Stem cells in intrinsic and extrinsic manners
- Impact of Endogenous Genomic Damage on Adult Stem Cells and Tissue Homeostasis
- Loss of PRC1 activity in different Stem cell compartments activates a common transcriptional program with cell type–dependent outcomes
- Senescence phenomena and metabolic alteration in mesenchymal stromal cells from a mouse model of Rett syndrome
- Roles of angiopoietin-like proteins in regulation of Stem cell activity
- Association of aplastic anaemia and lymphoma: a report from the severe aplastic anaemia working party of the European Society of Blood and Bone Marrow …
- Maintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis
- Mesenchymal niche-specific expression of Cxcl12 controls quiescence of treatment-resistant leukemia Stem cells
- Mesenchymal Stem cell secretion of SDF-1α modulates endothelial function in dilated cardiomyopathy
- A Phase I/II Study of Stem cell Transplantation Using a Single Cord Blood Unit Expanded Ex vivo with Nicotinamide Running Title: Nicotinamide-Expanded …
- Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction
- Epithelial–mesenchymal transition in the pathogenesis of idiopathic pulmonary fibrosis
- FGF10-FGFR2B signaling generates basal cells and drives alveolar epithelial regeneration by bronchial epithelial Stem cells after lung injury
- C/EBPβ is a critical mediator of IFN-α–induced exhaustion of chronic myeloid leukemia Stem cells
- Insights into human development and disease from human pluripotent Stem cell derived intestinal organoids
- PI3K alpha and delta promote hematopoietic Stem cell activation
- Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells
- Transcription factor USF1 is required for maintenance of germline Stem cells in male mice
- Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal Stem cells
- Paracrine Interaction of Cancer Stem cell Populations Is Regulated by the Senescence-Associated Secretory Phenotype (SASP)
- Metformin restores CNS remyelination capacity by rejuvenating aged Stem cells
- Adult neural Stem cells: born to last
- The 14q32. 31 DLK1-DIO3 MIR300 tumor suppressor promotes leukemogenesis by inducing cancer Stem cell quiescence and inhibiting NK cell anti-cancer immunity
- Accumulation of progerin affects the symmetry of cell division and is associated with impaired Wnt signaling and the mislocalization of nuclear envelope …
- Posttransplant hemophagocytic lymphohistiocytosis driven by myeloid cytokines and vicious cycles of T-cell and macrophage activation in humanized mice
- mTOR as a central regulator of lifespan and aging
- WUSCHEL acts as an auxin response rheostat to maintain apical Stem cells in Arabidopsis
- AMPK Restrains Epidermal Stem cell Aging by Inhibiting mTORC1-Induced Hyper-Proliferation
- Bone marrow mesenchymal Stem cells: Aging and tissue engineering applications to enhance bone healing
- Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation
- Attenuation of frailty in older adults with mesenchymal Stem cells
- Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis
- Mesenchymal Stem cells in homeostasis and syStemic diseases: hypothesis, evidences, and therapeutic opportunities
- Increased Ripk1-mediated bone marrow necroptosis leads to myelodysplasia and bone marrow failure in mice
- Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells
- Metformin delays satellite cell activation and maintains quiescence
- Is cellular senescence involved in cystic fibrosis?
- cell lineage trees: the central structure plus key dynamics of biological aging and formulating the limiting problem of robust organismal rejuvenation
- Implications of aging in plastic surgery
- Niche-specific factors dynamically regulate sebaceous gland Stem cells in the skin
- Role of physical exercise in the regulation of epigenetic mechanisms in inflammation, cancer, neurodegenerative diseases, and aging process
- Turning back time with emerging rejuvenation strategies
- The regenerating skeletal muscle niche guides muscle Stem cell self-renewal
- Diversity in the oligodendrocyte lineage: Plasticity or heterogeneity?
- Role of EZH2 in cell lineage determination and relative signaling pathways
- From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs
- Nad+ and aging: a focus on novel molecular mechanisms of werner syndrome
- Age-related gene and miRNA expression changes in airways of healthy individuals
- Molecular mechanisms of p63-mediated squamous cancer pathogenesis
- Measuring aging and identifying aging phenotypes in cancer survivors
- Longevity Research: Theological Implications
- Attenuated Acceleration to Leukemia after Ezh2 Loss in Nup98-HoxD13 (NHD13) Myelodysplastic Syndrome
- WUSCHEL acts as a rheostat on the auxin pathway to maintain apical Stem cells in Arabidopsis
- Centenarians overexpress pluripotency-related genes
- Lipotoxicity, aging, and muscle contractility: does fiber type matter?
- Impacts of dietary obesity on muscle Stem cell behaviors
- Nutrient sensing and redox balance: GCN2 as a new integrator in aging
- Characterization of mesoangioblast cell fate and improved promyogenic potential of a satellite cell -like subpopulation upon transplantation in dystrophic …
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- Effects of minocycline and rapamycin in gamma-irradiated human embryonic Stem cells-derived cerebral organoids
- Activation of the resident Skeletal Stem cell (SSC) for articular cartilage regeneration.
- NUCLEAR SEGREGATION OF RNA AS A POTENTIAL NOVEL MARKER AND REGULATION MECHANISM OF QUIESCENCE IN NEURAL Stem cell
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- Stem cells under the influence of alcohol: effects of ethanol consumption on Stem/progenitor cells
- Skin aging: The dermal perspective
- Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis
- In vitro and in vivo evaluation of possible pro-survival activities of PGE2, EGF, TPO and FLT3L on human hematopoiesis
- Obesity may accelerate the aging process
- Obesity-associated hypermetabolism and accelerated senescence of bone marrow stromal Stem cells suggest a potential mechanism for bone fragility
- CRISPR/Cas9-based dystrophin restoration reveals a novel role for dystrophin in bioenergetics and stress resistance of muscle progenitors
- Autophagy in hematopoietic Stem cells
- New insights into the role of epithelial–mesenchymal transition during aging
- Germline genetic predisposition to myeloid neoplasia from GATA2 gene mutations: lessons learned from two cases
- Maintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis
- Inhibiting the BMP Pathway Rescues Neural Stem cell Defects in Alzheimer’s Disease
- Aging alters transcriptional circuitries and SLUG-mediated cellular states of mouse mammary epithelium
- cell lineage trees: the central structure plus key dynamics of biological aging and formulating the limiting problem of comprehensive organismal rejuvenation
- Translating HSC niche biology for clinical applications
- MDS-associated mutations in germline GATA2 mutated patients with hematologic manifestations
- NKAP regulates senescence and cell death pathways in hematopoietic progenitors
- Histone H3 K4/9/27 Trimethylation Levels Regulate Wound Healing and Stem cell Dynamics in Adult Skin
- Cellular senescence in cardiac diseases
- Mesenchymal Stem cells targeting PI3K/AKT pathway in leukemic model
- Why does an aging smoker’s lung develop idiopathic pulmonary fibrosis and not chronic obstructive pulmonary disease?
- Plausible links between metabolic networks, Stem cells, and longevity
- Hematopoietic Stem cells: self-renewal and expansion
- Panel T17P01-Session I
- Cancer Stem cells
- Mesenchymal Stem Cells Inhibit Apoptosis Via Modulating AKT/Mtor Signaling Pathway in Radiation-Induced Bone Marrow Injury
- Latest advances in aging research and drug discovery
- Activin A contributes to the definition of a pro-oncogenic bone marrow microenvironment in t (12; 21) preleukemia
- Development of Gold Nanorod NIR Active Surfaces for Human Mesenchymal Stem cell Detachment
- The diet and the damage done
- Epigenetic aging clocks in ecology and evolution
- ADVANCEMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY IN RELATION TO PUBLIC HEALTH
- Models and studies of aging: Executive summary of a report from the U13 conference series
- Hypoxia and aging
- Stem cell Signaling and RNA Regulation in Regenerating Skeletal Muscle
- Adaptive endoplasmic reticulum stress signalling via IRE1α–XBP1 preserves self-renewal of haematopoietic and pre-leukaemic Stem cells
- Insulin signaling in bone marrow adipocytes
- Haematopoietic Stem cells in perisinusoidal niches are protected from ageing
- SOX2 expression diminishes with ageing in several tissues in mice and humans
- Quiescence entry, maintenance, and exit in adult Stem cells
- An interview with Gary D Hammer, MD, PhD
- The role of decidual mesenchymal Stem/stromal cell ageing in labour
- Healthy and pathological neurocognitive aging: spectral and functional connectivity analyses using magnetoencephalography
- Epigenetic changes as a target in aging haematopoietic Stem cells and age-related malignancies
- Disulfiram’s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase
- When the skin is in the center of interest: An aging issue
- Basic and translational aging research in China: present and future
- Characterizing the Induction of Senescence by Tau and Beta-Amyloid in Rat Astrocytes
- A microcavity array-based 4D cell culture platform
- Regenerative medicine in the digital age
- Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5
- Aging, lifestyle and dementia
- Embrace the fat when getting old
- The immunosuppressant drug azathioprine restrains adipogenesis of muscle Fibro/Adipogenic Progenitors from dystrophic mice by affecting AKT signaling
- Stimulation of hair growth by small molecules that activate autophagy
- DNA damage responses in ageing
- Doubled lifespan and patient‐like pathologies in progeria mice fed high‐fat diet
- Telomerase reverse transcriptase (TERT) in action: cross-talking with epigenetics
- A multi-institutional comparison of younger and older adults with sickle cell disease
- Hematologic improvement with iron chelation therapy in myelodysplastic syndromes: Clinical data, potential mechanisms, and outstanding questions
- Transient inhibition of mTORC1 signaling ameliorates irradiation-induced liver damage
- The genetics of aging: a vertebrate perspective
- Distinct patterns of hair graft survival after transplantation into 2 nonhealing ulcers: is location everything?
- Bone marrow stromal cells from β-thalassemia patients have impaired hematopoietic supportive capacity
- Translational control during developmental transitions
- Partial Reprogramming: A Shortcut to Rejuvenation
- Astrocyte senescence: evidence and significance
- Neurogenesis and brain aging
- Update on the pathogenesis of chronic obstructive pulmonary disease
- Embryonic Stem cells modulate the cancer-permissive microenvironment of human uveal melanoma
- Inflammatory bone marrow microenvironment
- The clinical impact and biological mechanisms of skeletal muscle aging
- Age-related schwannomatosis with potential exosome-mediated contribution to prostate hyperplasia: a case report and mini-review
- Cytological and molecular aspects of the ageing sperm
- Cellular senescence as a mechanism and target in chronic lung diseases
- Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging, and inflammation
- Preventing epidermal jet lag by resetting the circadian clock
- mTORC1 activity is essential for erythropoiesis and B cell lineage commitment
- Imaging in idiopathic pulmonary fibrosis: diagnosis and mimics
- The lysosome as a cellular centre for signalling, metabolism and quality control
- Frailty: what the South African surgeon needs to know
- Long noncoding transcriptome in chronic obstructive pulmonary disease
- The transcription factor Hey and nuclear lamins specify and maintain cell identity
- Checkpoint kinase 1 is essential for fetal and adult hematopoiesis
- The ezh2(sa1199) mutant zebrafish display no distinct phenotype
- On the fly: recent progress on autophagy and aging in Drosophila
- www. aging-us. com AGING 2019, Vol. 11, Advance
- Signaling pathways in leukemic Stem cells
- Modulation of bone and marrow niche by cholesterol
- Interference with the bromodomain epigenome readers drives p21 expression and tumor senescence
- Plasma-based strategies for therapeutic modulation of brain aging
- The consequences of ageing, progeroid syndromes and cellular senescence on mechanotransduction and the nucleus
- Potential role of E4orf1 protein in aging-associated impairment in glycemic control
- Autophagy and Tumorigenesis in Drosophila
- Extrinsic regulation of fate choice in mouse haematopoietic Stem cells
- Royal jelly and its components promote healthy aging and longevity: from animal models to humans
- Mechanisms of cellular rejuvenation
- The unexpected noncatalytic roles of histone modifiers in development and disease
- Environmental factors in successful aging: the potential impact of air pollution
- The role of lipids in aging-related metabolic changes
- The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo
- Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy
- Expression and prognosis analyses of runt-related transcription factor family in human leukemia
- Muscle Stem cells give rise to rhabdomyosarcomas in a severe mouse model of Duchenne muscular dystrophy
- Polycomb complexes in normal and malignant hematopoiesis
- Leukemia Stem cells in hematologic malignancies
- ZEB1 protects skeletal muscle from damage and is required for its regeneration
- The E3 ubiquitin ligase SPOP controls resolution of syStemic inflammation by triggering MYD88 degradation
- CBX7 Induces Self-Renewal of human normal and malignant hematopoietic Stem and progenitor cells by canonical and Non-canonical interactions
- Enhanced therapeutic potential of the secretome released from adipose-derived Stem cells by PGC-1α-driven upregulation of mitochondrial proliferation
- Future cell and gene therapy for osteoarthritis (OA): potential for using mammalian protein production platforms, irradiated and transfected protein packaging …
- Senolytics and senostatics as adjuvant tumour therapy
- Zika Virus Infection: Review Of Neuroimage Studies And The Relationship Between Findings And Time Of Infection
- microRNAs: epigenetic players in cancer and aging
- Epigenetic silencing of miRNA-338-5p and miRNA-421 drives SPINK1-positive prostate cancer
- The aging lung and idiopathic pulmonary fibrosis
- The human lung cell atlas: a high-resolution reference map of the human lung in health and disease
- Targeting angiogenesis in Duchenne muscular dystrophy
- Epigenetic reprogramming and emerging epigenetic therapies in CML
- Mouse models in modeling aging and cancer
- Freshwater Cnidarian Hydra: A Long-lived Model for Aging Studies
- Synovium-derived mesenchymal Stem/stromal cells and their promise for cartilage regeneration
- DNA methylation aging clocks: challenges and recommendations
- Past, present, and future of circ RNA s
- Myelodysplastic syndromes and idiopathic pulmonary fibrosis: a dangerous liaison
- p21 in cancer research
- A novel mammalian PIWI protein regulates self-renewal and lifespan of macrophages
- Age-related evolutions of the dermis: Clinical signs, fibroblast and extracellular matrix dynamics
- Priming mobilization of hair follicle Stem cells triggers permanent loss of regeneration after alkylating chemotherapy
- Latest Advances in Aging Research and Drug Discovery
- Muscle contracture and passive mechanics in cerebral palsy
- Epigenetic Regulation of Muscle Stem Cells During Skeletal Muscle Regeneration and Disease
- Hallmarks of aging in the liver
- Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy
- Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis
- The role of miR-210 in the biological syStem: a current overview
- MicroRNA function in megakaryocytes
- Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke
- Report of the Signal Transduction Society Meeting 2018—Signaling: From Past to Future
- The neuroprotective effect of bisperoxovandium (pyridin-2-squaramide) in intracerebral hemorrhage
- Interleukin-23 receptor signaling mediates cancer dormancy and radioresistance in human esophageal squamous carcinoma cells via the Wnt/Notch pathway
- Interfering with bromodomain epigenome readers as therapeutic option in mucoepidermoid carcinoma
- Extending Healthy Human Lifespan Using Gene Therapy
- Age-related alterations affecting the chondrogenic differentiation of synovial fluid mesenchymal stromal cells in an equine model
- cell senescence in lupus
- Putative role of nuclear factor-kappa B but not hypoxia-inducible factor-1α in hypoxia-dependent regulation of oxidative stress in hematopoietic Stem and progenitor …
- Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults
- p21cip1/waf1 coordinates autophagy, proliferation and apoptosis in response to metabolic stress
- Pericytes in muscular dystrophies
- DNA damage responses in ageing.
- Adaptive immunodeficiency in WHIM syndrome
- Adult T-type lymphoblastic lymphoma presenting as hypercalcemic crisis and aplastic anemia: a case report
- The curious case of dermal fibroblasts: cell identity loss may be a mechanism underlying cardiovascular aging
- Drugs that target aging: how do we discover them?
- Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation
- PML bodies in mitosis
- Genomic and Epigenomic Potential With Age: Genome, Epigenome, and the Epigenetic Clock
- Allostatic load and ageing: linking the microbiome and nutrition with age-related health
- Hair of the dog: identification of a cis-regulatory module predicted to influence canine coat composition
- Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis
- Basic and translational aging research in China: present and future
- Healthy aging: a bibliometric analysis of the literature
- The role of pathological aging in cardiac and pulmonary fibrosis
- Transcriptional and epigenetic mechanisms controlling intestinal cell fate
- Restoring the regenerative balance in neuromuscular disorders: satellite cell activation as therapeutic target in Pompe disease
- Vitamin D in physiological and pathological aging: Lesson from centenarians
- The role of DNA repair in cellular aging process
- EMT regulation by autophagy: a new perspective in glioblastoma biology
- The role of CXCR4 in multiple myeloma: Cells’ journey from bone marrow to beyond
- Mononuclear cell telomere attrition is associated with overall survival after nonmyeloablative allogeneic hematopoietic cell transplantation for hematologic …
- Viewpoint on the role of tissue maintenance in ageing: focus on biomarkers of bone, cartilage, muscle, and brain tissue maintenance
- Divide or commit–revisiting the role of cell cycle regulators in adult hippocampal neurogenesis
- The molecular clock in the skin, its functionality, and how it is disrupted in cutaneous melanoma: a new pharmacological target?
- The cGAS/STING pathway: a sensor of senescence-associated DNA damage and trigger of inflammation in early age-related macular degeneration
- The microbiome and aging
- Molecular pathways mediating immunosuppression in response to prolonged intensive physical training, low-energy availability, and intensive weight loss
- Time for the syStems-level integration of aging: resilience enhancing strategies to prevent Alzheimer’s disease
- Time for a new strategy in the war on Alzheimer’s disease
- Rejuvenation of Aged Heart Explant-Derived Cells for Repair of Ischemic Cardiomyopathy
- Cellular senescence in bone
- Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
- TRANSLATIONAL REVIEW
- Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells
- cell kinetics in the adult neurogenic niche and impact of diet-induced accelerated aging
- Serum CXCL2 Level Can Predict High-Fat Diet-Induced Impairment of Bone Marrow Mesenchymal Stem Cells
- Altered myogenesis and premature senescence underlie human TRIM32-related myopathy
- A role for CXC chemokines and their receptors in stress axis regulation of common carp
- The mTOR inhibitor everolimus overcomes CXCR4-mediated resistance to histone deacetylase inhibitor panobinostat through inhibition of p21 and mitotic regulators
- Exosome determinants of physiological aging and age-related neurodegenerative diseases
- A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress
- Mathematical model to study the aging of the human follicle according to the telomerase activity
- Toward understanding genomic instability, mitochondrial dysfunction and aging
- Nuclear organization in stress and aging
- Approaches towards longevity: reprogramming, senolysis, and improved mitotic competence as anti-aging therapies
- Inflammaging and oxidative stress in human diseases: from molecular mechanisms to novel treatments
- Epigenetic clock analysis of blood samples from Japanese schizophrenia patients
- Lung function trajectories in health and disease
- CDK7 inhibition as a promising therapeutic strategy for lung squamous cell carcinomas with a SOX2 amplification
- A concise review of human brain methylome during aging and neurodegenerative diseases
- FOXO3 on the road to longevity: lessons from SNPs and chromatin hubs
- A new member of the runt domain family from Pacific oyster Crassostrea gigas (CgRunx) potentially involved in immune response and larvae hematopoiesis
- Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML
- Evolving insights into the cellular and molecular pathogenesis of fibrosis in syStemic sclerosis
- Metabolism-based therapeutic strategies targeting cancer Stem cells
- A defined human aging phenome
- Measuring gait speed to better identify prodromal dementia
- The global clonal complexity of the murine blood syStem declines throughout life and after serial transplantation
- First hint that body’s ‘biological age’can be reversed
- Neuromuscular junction as an entity of nerve-muscle communication
- Developments in molecular epidemiology of aging
- Differential expression of phospho‐S6 in hair follicle tumors: Evidence of mammalian target of rapamycin pathway activation
- A regulatory pathway for medicines that target aging
- MicroRNAs and the genetic nexus of brain aging, neuroinflammation, neurodegeneration, and brain trauma
- Are we ill because we age?
- Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey
- Putative Role of Nuclear Factor-Kappa B But Not Hypoxia-Inducible Factor-1a in Hypoxia-Dependent Regulation of Oxidative Stress in Hematopoietic Stem and …
- What Is the Exposome and How It Can Help Research on Air Pollution
- Chaperones and their role in telomerase ribonucleoprotein biogenesis and telomere maintenance
- Classical monocytes from older adults maintain capacity for metabolic compensation during glucose deprivation and lipopolysaccharide stimulation
- Gene network analysis of senescence-associated genes in annual plants and comparative assessment of aging in perennials and animals
- Mechanisms and therapeutic prospects of thrombopoietin receptor agonists
- Age-related gene and miRNA expression changes in airways of healthy individuals
- The genomic health of human pluripotent Stem cells: genomic instability and the consequences on nuclear organization
- Dystrophic mdx mouse myoblasts exhibit elevated ATP/UTP-evoked metabotropic purinergic responses and alterations in calcium signalling
- Telomere-related gene mutations and lung diseases: Pulmonary fibrosis, emphysema and lung cancer
- Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors
- Comparative proteome-wide analysis of bone marrow microenvironment of β-thalassemia/hemoglobin E
- Ageing and cognition
- Revamping the evolutionary theories of aging
- Dementia: Module 2
- Cdk7: a kinase at the core of transcription and in the crosshairs of cancer drug discovery
- Structural analysis and conformational dynamics of STN1 gene mutations involved in coat plus syndrome
- Integrating functional ageing into daily clinical practice
- Telomere abnormalities in the pathobiology of idiopathic pulmonary fibrosis
- The Maintaining and Directed Differentiation of Hematopoietic Stem Cells Under Microgravity
- Psychological wellbeing and healthy aging: focus on telomeres
- Improving health in later life: how a life course approach could improve health and well-being in old Age
- NAD+ in brain aging and neurodegenerative disorders
- The Purification of Human Adult Progenitor cell Types to Promote Angiogenesis
- Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates
- Dynamic reciprocity: the role of the extracellular matrix microenvironment in amplifying and sustaining pathological lung fibrosis
- Telomere dynamics in children undergoing cancer treatment and the relationship between telomere length and treatment outcome
- Aging of immune syStem
- Identification of Chromatin Regulators Perturbed in Hematopoietic Stem and Progenitor cell Aging
- Hydroxytyrosol prevents dermal papilla cells inflammation under oxidative stress by inducing autophagy
- Inferring immunological control mechanisms from TKI dose alterations in CML patients
- A Nontarget Mechanism to Explain Carcinogenesis Following α-Irradiation
- The effect of exclusive olive oil consumption on successful aging: a combined analysis of the ATTICA and MEDIS epidemiological studies
- Characterization of LINC Complex-mediated Regulation of Satellite Stem and Progenitor cell Cycles
- Let-7 miRNA’s expression profile and its potential prognostic role in uterine leiomyosarcoma
- Investigating nutrient-sensing pathways in ageing human neural Stem cells and age-related cognitive decline
- The epidemiology of frailty and its association with disability and quality of life among rural community-dwelling older adults in Kegalle district of Sri Lanka
- Skeletal muscle Stem cells
- What is the level of dystrophin expression required for effective therapy of Duchenne muscular dystrophy?
- Somatic mutations in healthy cells and age-associated diseases
- Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis
- An inflammatory clock predicts multi-morbidity, immunosenescence and cardiovascular aging in humans
- Histological and Immunohistochemical Study of Selenium Regenerative Effect on Submandibular and Sublingual Glands of Aging Rats
- Trade-offs between mortality components in life history evolution: the case of cancers
- Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray
- Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair
- Infections in elderly intensive care unit patients
- The Human Lung cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease
- The role of E3 ubiquitin ligase FBXO9 in normal and malignant hematopoiesis
- Mitophagy, Diseases, and Aging
- NADPH oxidases and aging models of lung fibrosis
- Metformin Modulates the Mechanisms of Ageing
- Keratin 19 regulates cell cycle pathway and sensitivity of breast cancer cells to CDK inhibitors
- Metabolic Stress—Signaling and Metabolic Adaptation
- Role and Perspective of Sport Science in Health Promotion and Elite Sport
- Caveolin-1 as a critical component in the pathogenesis of lung fibrosis of different etiology: Evidences and mechanisms
- Molecular Signature of Aging Driven by Wnt Signaling Pathway: Lessons from Nematodes
- ZEB1 protects skeletal muscle from damage and is required for its regeneration
- The Origins of Ageing
- Identifying potential ageing-modulating drugs in silico
- The FMS-like tyrosine kinase-3 ligand/lung dendritic cell axis contributes to regulation of pulmonary fibrosis
- Monocytes from Older Adults Maintain Capacity for Metabolic Compensation during Glucose Deprivation and Lipopolysaccharide Stimulation
- The role of epigenetic aging in education and racial/ethnic mortality disparities among older US Women
- Genetic pathways of aging and their relevance in the dog as a natural model of human aging
- Chromosomal instability and pro-inflammatory response in aging
- Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis
- Premature aging syndromes: From patients to mechanism
- Quality of life in idiopathic pulmonary fibrosis: The impact of sleep disordered breathing
- Extraribosomal Regulation of Myeloid Leukemogenesis by Rpl22
- Differential gene expression changes and their implication on the disease progression in patients with chronic myeloid leukemia
- Multiomics Analysis of the mdx/mTR Mouse Model of Duchenne Muscular Dystrophy
- Studies on the effect of Time-Restricted Feeding on ageing and carcinogenesis
- The response to DNA damage at telomeric repeats and its consequences for telomere function
- Bioactive compounds as therapeutic alternatives
- The Cambridge handbook of successful aging
- PHYTOCHEMICALS AS PROSPECTIVE HUMAN ANTI-AGING COMPOUNDS
- Nuclear Organization in Stress and Aging
- Emerging roles of sestrins in neurodegenerative diseases: counteracting oxidative stress and beyond
- Histone modifications as an intersection between diet and longevity
- Targeting chronic innate inflammatory pathways, the main road to prevention of osteoarthritis progression
- Calcium mechanisms in limb-girdle muscular dystrophy with CAPN3 mutations
- Molecular Insights into Hutchinson-Gilford Progeria Syndrome and Age-associated Disease: From Mechanisms to Treatment Strategy
- Therapeutic targeting of transcriptional cyclin-dependent kinases
- Stammzellen und Akne Cellules souches et acné
- Epigenetics and ageing
- Targeting mitochondrial bioenergetics and NAD+ metabolism during sarcopenia and regeneration of skeletal muscle
- Ginger (Zingiber officinale Roscoe) in the prevention of ageing and degenerative diseases: review of current evidence
- Variable DNA methylation of aging-related genes is associated with male COPD
- Leveraging budding yeast Saccharomyces cerevisiae for discovering aging modulation substances for functional food
- Plant-rich dietary patterns, plant foods and nutrients, and telomere length
- Revisiting successful aging with HIV through a revised biopsychosocial model: An update of the literature
- Epigenetic aging is associated with clinical and experimental pain in community-dwelling older adults
- Negative conditioning of mitochondrial dysfunction in age-related neurodegenerative diseases
- What can yeast tell us about aging modulation by bioactive substances in functional food
- 11 Genetic Syndromes and Aging
- The cryo-EM structure of human CST reveals a two-megadalton decameric assembly bound to telomeric DNA
- Lifespan: Why we age—And why we Don’t have to
- Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes
- Down syndrome, ageing and epigenetics
- Transient Reprogramming for Multifaceted Reversal of Aging Phenotypes
- Two stochastic processes shape diverse senescence patterns in a single‐cell organism
- Longitudinal associations of physical activity levels with morphological and functional changes related with aging: The MAPT study
- Genetic Syndromes and Aging
- Adipogenesis of skeletal muscle Fibro/Adipogenic Progenitors is controlled by the WNT5a/GSK3/β-catenin axis
- Determinants and prevention of coronary disease in patients with chronic kidney disease
- G protein-coupled receptor syStems and their role in cellular senescence
- Total energy expenditure measured using doubly labeled water compared with estimated energy requirements in older adults (≥ 65 y): analysis of primary data
- The metabolomics side of frailty: Toward personalized medicine for the aged
- The vivo antioxidant activity of self-made aged garlic extract on the d-galactose-induced mice and its mechanism research via gene chip analysis
- Current state of saliva biomarkers for aging and Alzheimer’s disease
- Immunohistochemistry and molecular biology in transbronchial cryobiopsies
- A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells
- Early induction of C/EBPβ expression as a potential marker of steroid responsive colitis
- and Venerino Poletti
- Cataractogenic load–A concept to study the contribution of ionizing radiation to accelerated aging in the eye lens
- Role of obesity in the development of acute promyelocytic leukemia (APL)
- Cognitive and Brain Aging: Interventions to Promote Well-Being in Old Age
- The microbiota-gut-brain axis
- Role of combined lipoic acid and vitamin D3 on astrocytes as a way to prevent brain ageing by induced oxidative stress and iron accumulation
- Slowing down ageing: the role of nutrients and microbiota in modulation of the epigenome
- Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association
- Identifying blood-specific age-related DNA methylation markers on the Illumina MethylationEPIC® BeadChip
- Effects of aging and diet on cardioprotection and cardiometabolic risk markers
- Hydrogen Sulfide Improves Aberrant Gastric Smooth Muscle Function in Duchenne Muscular Dysrophy Mice
- Metabolism of sleep and aging: Bridging the gap using metabolomics
- Is Nature our Best Assurance of Healthy Ageing? Lessons from age-resilient animal species
- Functional characterization and clinical relevance of ubiquitin conjugating enzyme E2T in hepatocellular carcinoma
- Oxidative stress induces telomere dysfunction and senescence by replication fork arrest
- DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis
- Identifying Rare Somatic Mutations as a Means of Understanding Tissue Clonal Evolution
- Stem Cells: From Myth to Reality and Evolving
- Bone-resident mesenchymal stromal cells in healthy ageing and osteoarthritis: enumeration and gene expression analysis in uncultured cells
- The role of arginase in aging: a syStematic review
- Chance and causality in ageing and Longevity
- Rational particle design to overcome pulmonary barriers for obstructive lung diseases therapy
- The role of Stem cells in development of heart failure associated with Duchenne muscular dystrophy
- Prophylaxis of non-communicable diseases: why fruits and vegetables may be better chemopreventive agents than dietary supplements based on isolated …
- The role of lipid metabolism in aging, lifespan regulation, and age‐related disease
- Conditioning Medicine
- Handgrip strength and pulmonary disease in the elderly: what is the link?
- Relationships between ion channels, mitochondrial functions and inflammation in human aging
- Implication of the receptor for advanced glycation end-products (RAGE) during inflammation and ageing
- DNA methylation in genes of longevity-regulating pathways: association with obesity and metabolic complications
- States and Fates of Primitive Neural Stem Cells and Their Progeny in the Mammalian Brain
- Caloric restriction and the nutrient-sensing protein kinase TOR1 alter the pattern of protein phosphorylation in quiescent and non-quiescent cells of Saccharomyces …
- Brain region-specific effects of long-term caloric restriction on redox balance of the aging rat
- Mechanisms of heat-induced lifespan extension in Saccharomyces cerevisiae and Caenorhabditis elegans
- Redox imbalance in idiopathic pulmonary fibrosis: a role for oxidant cross-talk between NADPH oxidase enzymes and mitochondria
- The Role of mtDNA Mutation and Mitochondrial Dysfunction on the Aging Process
- Conserved signaling pathways genetically associated with longevity across the species
- Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: the Drosophila approach
- Análisis genómico y funcional de las células madre mesenquimales de médula ósea de pacientes osteoporóticos
- Better options for best clinical practice
- Mitochondria in the signaling pathways that control longevity and health span
- TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair
- Marmosets in aging research
- Vesicles and microRNAs of the senescence-associated-secretory-phenotype: An evaluation of their anti-apoptotic effect on dermal fibroblasts
- Metabolic Flexibility in Classical Monocytes is not Affected by Age
- Xiaqing Zhao and Daniel EL Promislow
- Agephagy–Adapting autophagy for health during aging
- LAMINOPATHIES: PATHOLOGY, cell MECHANICS ANDENVIRONMENTAL INDUCTION.
- Pharmacological Management of Chronic Obstructive Lung Disease (COPD). Focus on Mutations-Part 1
- Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase
- Rare Cells Play Central Roles in Airway Maintenance
- Osteopontin role in lipid metabolism: involvement in age-related hepatosteatosis
- How does allostatic load relate to cognitive ability, depressive symptoms and other measures of physiological weathering in older age?
- Ssu72 phosphatase is a conserved telomere replication terminator
- Linker histones and chromatin remodelling complexes maintain genome stability and control cellular ageing
- Frailty syndrome and cognitive impairment in older adults: syStematic review of the literature
- On the epigenetic ageing clock in humans
- Praise for LIFESPAN
- Circadian Oscillations of the Mouse and Human Epigenome
- Circadian Oscillations of the Mouse and Human Epigenome
- Antagonism of the Thromboxane‐Prostanoid Receptor as a Potential Therapy for Cardiomyopathy of Muscular Dystrophy
- Clinical and Preclinical Application of Magnetic Resonance Spectroscopy in Aging and Amyotrophic Lateral Sclerosis
- DNA methylation changes during aging and in age-associated diseases
- Probing the impact of the maternal environment on foetal development: Can high-resolution telomere analysis predict prenatal adversity?
- RECQL4; Linking DNA Replication and Bone Tumourigenesis
- Human CST complex protects replication fork stability by directly blocking MRE11 degradation of nascent strand DNA
- Towards a unified mechanistic theory of aging
- Modulating Aging and Aging-related Symptoms Using Endogenous Small Molecules
- Oxidative Stress-Induced Autophagy Impairment and Pathogenesis
- The Biology of Senescence
- DNA methylation patterns in aging and aging phenotypes
- Oxidative Stress-Induced Autophagy Impairment and Pathogenesis of Chronic Obstructive Lung Diseases
- Geriatric Anesthesia
- Difficult to Diagnose Rare Diffuse Lung Disease
- Cellular calcium signaling in the aging brain
- Mitophagy and oxidation status of mitochondria in Idiopathic Pulmonary Fibrosis (IPF) macrophages: a study in bronchoalveolar lavage fluid (BALF)
- Mammalian CST averts replication failure by preventing G-quadruplex accumulation
- Age-and tumor-dependent senescence in canine testis and eye
- Identifying MicroRNAs Responsible for the Opposite Longevity Roles of Caenorhabditis elegans Argonautes
- Investigating Telomere Length Dynamics In Human Endothelial Cells
- Intrarenal Renin–Angiotensin SyStem Involvement in the Pathogenesis of Chronic Progressive Nephropathy—Bridging the Informational Gap Between Disciplines
- GFI1B Regulation and Transcriptional Repression Depend on Its Interacting Partners
- The Use of the Drosophila Genetic Reference Panel to Map Genes Underlying High Fat Diet-induced Mortality
- High-Throughput Chronological Lifespan Screening of the Fission Yeast Deletion Library Using Barcode Sequencing
- TRF1 prevents permissive DNA damage response, recombination and Break Induced Replication at telomeres
- The delta opioid receptor influences circadian rhythms in human N/TERT‑1 keratinocytes through the β‑arrestin pathway
- Jump Start Autophagy: Activate Your Body’s Cellular Healing Process to Reduce Inflammation, Fight Chronic Illness and Live a Longer, Healthier Life
- Glucose Availability Impacts Proteotoxic Stress in Caenorhabditis Elegans
- A mitochondrial approach to cardiovascular risk and disease
- Epigenetics and pharmacoepigenetics of age-related neurodegenerative disorders
- Analysis of CDK2 Function During Meiosis
- Development of dystrophin-based biomarker for penaeid shrimps/Raji Fatimah Omotayo
- Pro-Senescence Therapy by Targeting MYC and Its Network as a Strategy to Combat Cancer
- Targeting cell Intrinsic and Extrinsic Mechanisms Involved in the Initiation and Maintenance of Non-Small cell Lung Cancer
- Role of Antioxidants in the Protection from Aging-Related Diseases
- Discovering and Targeting the Mechanisms that Govern Age-Related Decline
- Mechanisms of fibrosis in IPF
- Impact of cardiovascular and neuropsychiatric multimorbidity on older adults’ health
- Identification of DDX1 as a novel interactor of CDK-Activating Kinase and its implication in Trichothiodystrophy disorder
- Mind-Body Wellness Program Benefits
- Explaining infertility: a Sperm DNA Fragmentation review
- Retrotransposition and Ageing-associated Neuronal Function Decline
- Intrinsically Disorder Proteins and Liquid-Liquid Phase Transitions in Neurodegenerative Diseases
- Reverse Engineering of Natural SyStems by Graph Theory
- Fasting-mimicking diet-based non-toxic combination therapy in cancer treatment: from molecules to bedside
- Long Live The Queen: influence of membrane phospholipids on longevity of honey bees
- Study of Epigenetic Signatures Associated with Neuronal Differentiation, Aging and Alzheimer’s Disease
- Imaging of Interstitial Lung Diseases
- Correlating the prevalence of C174G polymorphism with IL-6, TNF-α and Hs-CRP in an elderly black South African population.
- Demographics and Telomere Dynamics of Hibernating Arctic Ground Squirrels (Urocitellus parryii)
- Transforming the future of ageing: informs the forthcoming Scientific Opinion of the European Commission Group of Chief Scientific Advisors
- Age-related changes of glutathione homeostasis in Caenorhabditis elegans
- The mitochondrial ageing signature; seeing the light
- Novel Insights into the Molecular Mechanisms that Control Stress Responses in Senescent Cells
- The role of the C. elegans Aryl hydrocarbon receptor in environmentally-driven aging
- Design and Implementation of A Fully Reconstituted Assay To Investigate Mechanisms of Early Human Pol II Transcription
- TGF-β mediated synthesis of degradation-resistant collagen (I) homotrimer in musculoskeletal cells
- A Neuronal G Protein-coupled Receptor Mediates the Effect of Diet on Lifespan and Development in Caenorhabditis elegans Through Autophagy
- Hes1 deficiency causes hematopoietic Stem cell exhaustion
- The mitochondria regulation of Stem cell aging
- ATF3 Prevents Stress-Induced Hematopoietic Stem cell exhaustion
- Emerging role of Stem cell -derived extracellular microRNAs in age-associated human diseases and in different therapies of longevity
- Combined antioxidant, anti-inflammaging and mesenchymal Stem cell treatment: a possible therapeutic direction in elderly patients with chronic obstructive …
- Arabidopsis Casein Kinase 2 triggers Stem cell exhaustion under Al Toxicity and Phosphate Deficiency Through activation of the DNA Damage Response pathway
- Senescent Mesenchymal Stem Cells: Disease Mechanism and Treatment Strategy
- Small molecules restore telomeres in patient Stem cells
- Protection of hematopoietic Stem cells from stress-induced exhaustion and aging
- Myf6/MRF4 is a myogenic niche regulator required for the maintenance of the muscle Stem cell pool
- Small-molecule PAPD5 inhibitors restore telomerase activity in patient Stem cells
- Comprehensive analysis of skeletal muscle-and bone-derived mesenchymal Stem/stromal cells in patients with osteoarthritis and femoral neck fracture
- The role of the Stem cell epigenome in normal aging and rejuvenative therapy
- Stem Cells and Aging
- Stem cell aging in lifespan and disease: A state-of-the-art review
- Human basal cell carcinoma: the induction of anagen hair follicle differentiation
- Substance P aggravates corneal epithelial Stem cell deficiency
- Extracellular vesicles from healthy cells improves cell function and Stemness in premature senescent Stem cells by miR-302b and HIF-1α activation
- Distal lung epithelial progenitor cell function declines with age
- Sestrins regulate age-induced deterioration of muscle Stem cell homeostasis
- Stem cell DNA damage and genome mutation in the context of aging and cancer initiation
- Of mesenchymal Stem/stromal cells and osteoarthritis: time to merge the latest breakthroughs
- Elevated p38MAPK activity promotes neural Stem cell aging
- Pluripotent Stem cell -based cell therapy—promise and challenges
- Ttc7a regulates hematopoietic Stem cell functions while controlling the stress-induced response
- Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal Stem cells
- Vitamin D receptor controls cell Stemness in acute myeloid leukemia and in normal bone marrow
- Increased exhaustion of the subchondral bone-derived mesenchymal Stem/stromal cells in primary versus dysplastic osteoarthritis
- Hair follicle differentiation‐specific keratin expression in human basal cell carcinoma
- Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic Stem cell populations
- The dual role of ROS in hematological malignancies: Stem cell protection and cancer cell metastasis
- How cancer therapeutics cause accelerated aging: Insights from the hallmarks of aging
- Functional changes in decidual mesenchymal Stem/stromal cells are associated with spontaneous onset of labour
- Treating osteoarthritis via gene therapy with rejuvenation factors
- Metabolic regulation and related molecular mechanisms in various Stem cell functions
- Humanized zebrafish enhance human hematopoietic Stem cell survival and promote acute myeloid leukemia clonal diversity
- Rapamycin for aging Stem cells
- Hematopoietic Stem cell metabolism during development and aging
- Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
- Hematopoietic Stem cell regulation by the proteostasis network
- Reducing hypothalamic Stem cell senescence protects against aging-associated physiological decline
- Somatic selection of poorly differentiating variant Stem cell clones could be a key to human ageing
- Targeting aging pathways in chronic obstructive pulmonary disease
- ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells
- Interplay of mitochondrial fission-fusion with cell cycle regulation: Possible impacts on Stem cell and organismal aging
- Lipid mediated regulation of adult Stem cell behavior
- Dietary Restriction Delays But Cannot Heal Irradiation-Induced Hair Graying by Preserving Hair Follicle Stem Cells in Quiescence
- Stem cell ageing of the root apical meriStem of Arabidopsis thaliana
- IPA Software Analysis Reveals Inflammation and Apoptosis as Major Enrichment Functional Process in Normal Lung During Aging
- Introductions to the community: Early-career researchers in the time of COVID-19
- MTORC1 and the Rebirth of Stemness
- Metabolic dysfunction in Hutchinson–Gilford progeria syndrome
- Treating osteoarthritis via gene therapy with rejuvenation factors
- Exercise protects proliferative muscle satellite cells against exhaustion via the Igfbp7-Akt-mTOR axis
- Stem cell aging in skeletal muscle regeneration and disease
- Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the Stem cell -derived airway repair response
- The role of metabolic plasticity in blood and brain Stem cell pathophysiology
- The aging skin microenvironment dictates Stem cell behavior
- Aging and rejuvenation of neural Stem cells and their niches
- The intrinsic proteostasis network of Stem cells
- Application of the Frameworks of Intrinsic Capacity and the Hallmarks of Aging to Validate Nicotinamide Riboside as a Healthy Aging Supplement–A Meta-Analysis
- Deregulated mito-nuclear communication alters chromatin plasticity and differentiation potential of mesenchymal Stem cells upon ageing
- Mesenchymal Stem cell derived extracellular vesicles in aging
- Of mice, genes and aging
- FOXO activity adaptation safeguards the hematopoietic Stem cell compartment in hyperglycemia
- Glutamine metabolism controls Stem cell fate reversibility and long-term maintenance in the hair follicle
- Loss of Tissue Regenerative Ca-pacity in Aging-The Tendon
- Boosting mitochondrial biogenesis for healthy ageing
- Ageing, metabolism and the intestine
- Ageing in human parturition: impetus of the gestation clock in the decidua
- Benefits of metformin in attenuating the hallmarks of aging
- Notch signaling mitigates chemotherapy toxicity by accelerating hematopoietic Stem cells proliferation via c-Myc
- Aging of the ventricular-subventricular zone neural Stem cell niche
- MicroRNAs in hematopoietic Stem cell aging
- How Could We Slow or Reverse the Human Aging Process and Extend the Healthy Life Span with Heterochronous Autologous Hematopoietic Stem cell …
- Signal transduction in the early Drosophila follicle Stem cell lineage
- DNA repair fidelity in Stem cell maintenance, health, and disease
- Neuroimmune/hematopoietic axis with distinct regulation by the high-mobility group box 1 in association with tachykinin peptides
- Extracellular serine controls epidermal Stem cell fate and tumour initiation
- The eroding chromatin landscape of aging Stem cells
- FoxO maintains a genuine muscle Stem–cell quiescent state until geriatric age
- Epigenetic clock: DNA methylation in aging
- Ganoderic acid D protects human amniotic mesenchymal Stem cells against oxidative stress-induced senescence through the PERK/NRF2 signaling pathway
- Restoring aged Stem cell functionality: Current progress and future directions
- Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging
- Mechanisms and rejuvenation strategies for aged hematopoietic Stem cells
- C/EBPβ-dependent epigenetic memory induces trained immunity in hematopoietic Stem cells
- Are trade‐offs really the key drivers of ageing and life span?
- Adipose stromal cell expansion and exhaustion : Mechanisms and consequences
- Expression levels of SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) and its interacting partners show region-specific alterations during brain aging
- A novel tissue culture model for evaluating the effect of aging on Stem cell fate in adult microvascular networks
- Attenuated regenerative properties in human periodontal ligament–derived Stem cells of older donor ages with shorter telomere length and lower SSEA4 expression
- Dietary phytochemical approaches to Stem cell regulation
- Transient “rest” induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells
- Modification of Stem cell states by alcohol and acetaldehyde
- GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic Stem cells
- Targeting cardiac Stem cell senescence to treat cardiac aging and disease
- Hypercholesterolemia accelerates the aging phenotypes of hematopoietic Stem cells by a Tet1-dependent pathway
- Aging-related reduced expression of CXCR4 on bone marrow mesenchymal stromal cells contributes to hematopoietic Stem and progenitor cell defects
- Revisiting the hallmarks of aging to identify markers of biological age
- Stem cells and lung regeneration
- The landscape of GPCR signaling in the regulation of epidermal Stem cell fate and skin homeostasis
- The changing epigenetic landscape of mesenchymal Stem/stromal cells during aging
- TICAM2-related pathway mediates neutrophil exhaustion
- Measuring biological aging in humans: A quest
- Prolonged hypoxia delays aging and preserves functionality of human amniotic fluid Stem cells
- Hallmarks of aging Drosophila intestinal Stem cells
- Notch dimerization and gene dosage are important for normal heart development, intestinal Stem cell maintenance, and splenic marginal zone B-cell …
- Senescence in pulmonary fibrosis: between aging and exposure
- PI3K in Stemness regulation: From development to cancer
- Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells
- Organoid models in lung regeneration and cancer
- Therapeutic strategies targeting somatic Stem cells: Chemical approaches
- Tet1 deficiency leads to premature reproductive aging by reducing spermatogonia Stem cells and germ cell differentiation
- Progressive changes in hippocampal Stem cell properties ensure lifelong neurogenesis
- Persistent DNA damage–induced NLRP12 improves hematopoietic Stem cell function
- Novel Therapeutics for Bone Marrow Failure Disorders Due to Telomere exhaustion
- Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
- Cellular senescence: A pathogenic mechanism of pelvic organ prolapse
- Mouth-watering results: clinical need, current approaches, and future directions for salivary gland regeneration
- Targeting the aryl hydrocarbon receptor in Stem cells to improve the use of food as medicine
- Aging skin and non-surgical procedures: a basic science overview
- The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
- AQP5 regulates the proliferation and differentiation of epidermal Stem cells in skin aging
- Mechanoregulation in hematopoiesis and hematologic disorders
- Elderly patients with multiple comorbidities: insights from the bedside to the bench and programmatic directions for this new challenge in lung transplantation
- mTOR signaling at the crossroad between metazoan regeneration and human diseases
- Type I interferons and related pathways in cell senescence
- Adult neurogenesis and the molecular signalling pathways in brain: The role of Stem cells in adult hippocampal neurogenesis
- EphA7+ perivascular cells as myogenic and angiogenic precursors improving skeletal muscle regeneration in a muscular dystrophic mouse model
- Does clonal hematopoiesis explain unexplained anemia?
- Polyamine-controlled proliferation and protein biosynthesis are independent determinants of hair follicle Stem cell fate
- Its written all over your face: The molecular and physiological consequences of aging skin
- Retention of somatic memory associated with cell identity, age and metabolism in induced pluripotent Stem (iPS) cells reprogramming
- CXCR4s in teleosts: two paralogous chemokine receptors and their roles in hematopoietic Stem/progenitor cell homeostasis
- Lack of PKCθ promotes regenerative ability of muscle Stem cells in chronic muscle injury
- Eltrombopag treatment promotes platelet recovery and reduces platelet transfusion for patients with post-transplantation thrombocytopenia
- Nutrient sensing, the oxidative stress response, and Stem cell aging
- FOOTNOTES
- Anti-aging effects of Ribes meyeri anthocyanins on neural Stem cells and aging mice
- Regulation of Stress Induced Hematopoiesis
- New insights into the basic biology of acute graft-versus-host-disease
- Dissecting Clonal Heterogeneity in AML
- cell polarity in hematopoietic Stem cell quiescence, signaling and fate determination
- The ageing epigenome and its rejuvenation
- Exposure to mites sensitizes intestinal Stem cell maintenance, splenic marginal zone B cell homeostasis, and heart development to notch dosage and cooperativity
- Sex hormone replacement therapy in periodontology—A syStematic review
- Focus: Sex & Reproduction: Impact of Ovarian Aging in Reproduction: From Telomeres and Mice Models to Ovarian Rejuvenation
- The Powerful Roles of Nad+ in Anti-Aging
- Skeletal Muscle Stem cell Niche from Birth to Old Age
- ITGB1 promotes the chondrogenic differentiation of human adipose-derived mesenchymal Stem cells by activating the ERK signaling
- Effects of pre-and/or postnatal smoke exposure on the hallmarks of the ageing phenotype and the role for the IGF1 pathway
- TSC1 regulates the proliferation capacity of bone-marrow derived mesenchymal Stem cells
- CXCR4 expression in the bone marrow microenvironment is required for hematopoietic Stem and progenitor cell maintenance and early hematopoietic regeneration …
- Senescence and longevity of sea urchins
- Understanding “LONGEVITY” at Molecular Level. A Comprehensive Review.
- Metabolic syndrome impairs 3D mitochondrial structure, dynamics, and function in swine mesenchymal Stem cells
- Frailty and aging in cancer survivors
- SOX2 in development and cancer biology
- Neuroinflammation and oxidative stress in the aging brain: Linking in metabolism, Stem cells, proteostasis, and stress adaptation
- Role of cell Cycle Control, Checkpoints, and DNA Repair Mechanisms in Stem Cells and Changes with Aging and Cancerogenesis
- Gerobiotics: probiotics targeting fundamental aging processes
- Global dynamics of healthy and cancer cells competing in the hematopoietic syStem
- Regulation of Stem Cells by Cullin-RING Ligase
- Single-cell lineage tracing unveils a role for TCF15 in haematopoiesis
- Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts
- EZH2 function in immune cell development
- Biomarkers of cognitive impairment in late-life depression
- Driver mutations in leukemia promote disease pathogenesis through a combination of cell -autonomous and niche modulation
- Culture nTAD: A New Avenue for Research in Late-stage Human Lung Development and Perinatal Lung Disease
- Decrease of laminin-511 in the basement membrane due to photoaging reduces epidermal Stem/progenitor cells
- Comparison of chronic myeloid leukemia Stem cells and hematopoietic Stem cells by global proteomic analysis
- Integrating the hallmarks of aging throughout the tree of life: a focus on mitochondrial dysfunction
- Redox regulation of regulatory T-cell differentiation and functions
- Crosstalk between autophagy and metabolic regulation of cancer Stem cells
- Targeting PPAR ligands as possible approaches for metabolic reprogramming of T cells in cancer immunotherapy
- Lifestyle mediates the role of nutrient-sensing pathways in cognitive aging: cellular and epidemiological evidence
- Regulation of the bone marrow niche by inflammation
- Dystrophin Dp71ab is monoclonally expressed in human satellite cells and enhances proliferation of myoblast cells
- Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal Stem cells through the aryl hydrocarbon receptor pathway
- Memory of divisional history directs the continuous process of primitive hematopoietic lineage commitment
- Mitochondria and ageing with HIV
- Polycomb Repressive Complex 1 is required to maintain Stem cell identity and to preserve adult tissue homeostasis.
- Chromatin Disorganization as a Regulator of Irradiation-Induced L1Md Expression and Hematopoietic Stem cell Function
- Switching of vascular cells towards atherogenesis, and other factors contributing to atherosclerosis: a syStematic review
- How can aging be reversed? Exploring rejuvenation from a damage‐based perspective
- Transglutaminase type 2 is involved in the hematopoietic Stem cells homeostasis
- Fabry disease: A new model of premature ageing?
- Sestrin family–the Stem controlling healthy ageing
- Menopausal hyperinsulinism and hypertension–new approach
- Skeletal Muscle Stem Cells
- The untapped potential of reptile biodiversity for understanding how and why animals age
- Effects of Trimethylamine N-Oxide on Mouse Embryonic Stem cell Properties
- mTOR in the aging imune syStem
- Characterising Senescence with High-content Imaging and Convolutional Neural Networks
- Effects of varying levels and differing durations of calorie restriction on cellular and synaptic proteins, as well as the inflammatory state of the female mouse brain
- COVID-19 and crosstalk with the hallmarks of aging
- Molecular connections between circadian clocks and aging
- Bone marrow mesenchymal Stem cells differentiate into intestinal epithelioid cells through the ERK1/2 pathway
- Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF
- Silver fir (Abies alba L.) polyphenolic extract shows beneficial influence on chondrogenesis in vitro under normal and inflammatory conditions
- Microglia Phagocytosis Contributes to Neural Stem cell Loss in the Aging Subventricular Zone
- SOX2 and p53 expression control converges in PI3K/AKT signaling with versatile implications for Stemness and cancer
- HNF4 regulates fatty acid oxidation and is required for renewal of intestinal Stem cells in mice
- Molecular Regulation of Satellite cell Fate
- Mesenchymal Stem/stromal cell -derived exosomes for immunomodulatory therapeutics and skin regeneration
- FBW7 mediates senescence and pulmonary fibrosis through telomere uncapping
- Piggybac Transposon-Based Lineage Tracing to Reveal Ependymogenesis
- Deficiency of Crif1 in hair follicle Stem cells retards hair growth cycle in adult mice
- Bone marrow stromal cell therapy improves survival after radiation injury but does not restore endogenous hematopoiesis
- Senescent cells: emerging targets for human aging and age-related diseases
- Satellite cells in ageing: use it or lose it
- Frailty in patients with interstitial lung disease
- Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease
- Pathophysiology of premature aging characteristics in Mendelian progeroid disorders
- Derivation and characterization of immortalized human muscle satellite cell clones from muscular dystrophy patients and healthy individuals
- Too much iron: A masked foe for leukemias
- The cGAS-STING pathway in hematopoiesis and its physiopathological significance
- Effect of exercise on telomere length and telomere proteins expression in mdx mice
- Senotherapeutics: targeting senescence in idiopathic pulmonary fibrosis
- Periodontal disease and senescent cells: new players for an old oral health problem?
- Wound induced hair neogenesis–a novel paradigm for studying regeneration and aging
- Aging and leukemic evolution of hematopoietic Stem cells under various stress conditions
- Global Age-Specific Patterns of Cyclic Gene Expression Revealed by Tunicate Transcriptome Atlas
- The E3 ubiquitin ligase CHIP in normal cell function and in disease conditions
- Contribution of aberrant toll like receptor signaling to the pathogenesis of myelodysplastic syndromes
- Vitamin C Treatment Rescues Prelamin A-Induced Premature Senescence of Subchondral Bone Mesenchymal Stem Cells
- Stem cells of the aging brain
- Single-cell Analysis of Muscle Stem cell Heterogeneity in Tissue Regeneration
- Persistence of drug-resistant leukemic Stem cells and impaired NK cell immunity in CML patients depend on MIR300 antiproliferative and PP2A-activating …
- Hematopoietic Stem Cells and Control of Hematopoiesis
- Chromatin Accessibility Dynamics Underlie a Decline in Neural Stem cell Migratory Ability with Age
- Discontinuation of tyrosine kinase inhibitors in chronic myeloid leukemia: when and for whom?
- Myocyte-derived Myomaker expression is required for regenerative fusion but exacerbates membrane instability in dystrophic myofibers
- Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis
- Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal Stem cells through different molecular targets
- Molecular mechanisms contributing to mesenchymal stromal cell aging
- ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin
- Mechanisms of melanocyte polarity and differentiation: What can we learn from other neuroectoderm-derived lineages?
- Nicotinamide riboside enhances mitochondrial proteostasis and adult neurogenesis through activation of mitochondrial unfolded protein response signaling …
- CD86-based analysis enables observation of bona fide hematopoietic responses
- C/EBPβ isoforms sequentially regulate regenerating mouse hematopoietic Stem/progenitor cells
- 15-PGDH as a Negative Regulator of Age-Related Organ Fitness
- cell and gene therapy for spine regeneration: Mammalian protein production platforms for overproduction of therapeutic proteins and growth factors
- An update on the molecular pillars of aging
- TOR signaling inhibition in intestinal Stem and progenitor cells affects physiology and metabolism in Drosophila
- MMR-proficient and MMR-deficient colorectal cancer cells: 5-Fluorouracil treatment response and correlation to CD133 and MGMT expression
- Elixir of Youth: Lipid Signaling Chaperones Synthesized in the Liver
- The Hippo–YAP Signaling as Guardian in the Pool of Intestinal Stem Cells
- RUNX1 gene mutations are associated with adverse prognosis of patients with acute myeloidleukemia
- Redox signaling in cellular differentiation
- Mitochondrial dynamics and metabolism in induced pluripotency
- Successful gene therapy of Diamond-Blackfan anemia in a mouse model and human CD34+ cord blood hematopoietic Stem cells using a clinically applicable …
- Caloric restriction reprograms the single-cell transcriptional landscape of Rattus norvegicus aging
- Aging and the biological response to liver injury
- Wnts and the hallmarks of cancer
- TIGAR/AP-1 axis accelerates the division of Lgr5− reserve intestinal Stem cells to reestablish intestinal architecture after lethal radiation
- Therapeutic strategies for Duchenne muscular dystrophy: an update
- Aging Biomarkers: From Functional Tests to Multi‐Omics Approaches
- Heterogenetic parabiosis between healthy and dystrophic mice improve the histopathology in muscular dystrophy
- Lighting up live-cell and in vivo central carbon metabolism with genetically encoded fluorescent sensors
- Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia
- Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA)
- Treating age-related multimorbidity: the drug discovery challenge
- Live long and prosper: Short-circuiting the process of ageing
- CDK7 inhibitors as anticancer drugs
- SIV infection and the HIV proteins Tat and Nef induce senescence in adipose tissue and human adipose Stem cells, resulting in adipocyte dysfunction
- RUNX transcription factor mediated control of breast cancer Stem cells
- Awakening the HSC: dynamic modeling of HSC maintenance unravels regulation of the TP53 pathway and quiescence
- Proteomics of Long‐Lived Mammals
- Granulins regulate aging kinetics in the adult zebrafish telencephalon
- Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo
- Competitive sgRNA screen identifies p38 MAPK as a druggable target to improve HSPC engraftment
- Is anti-ageing drug discovery becoming a reality?
- Aberrant RhoA activation in macrophages increases senescence-associated secretory phenotypes and ectopic calcification in muscular dystrophic mice
- A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome …
- Brain Age as a Measure of Brain Reserve in Neuropsychiatric Disorders
- Coinhibition of activated p38 MAPKα and mTORC1 potentiates Stemness maintenance of HSCs from SR1-expanded human cord blood CD34+ cells via inhibition of …
- Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs
- Central nervous syStem lesions in Fanconi anemia: Experience from a research center for Fanconi anemia patients
- p16 a biomarker of aging and tolerance for cancer therapy
- Chronic kidney disease: a vicarious relation to premature cell senescence
- Lung regeneration: implications of the diseased niche and ageing
- Review of neuroimaging findings in congenital Zika virus syndrome and its relation to the time of infection
- Networks, Stem Cells, and Longevity
- Angelica sinensis polysaccharides ameliorate 5-flourouracil-induced bone marrow stromal cell proliferation inhibition via regulating Wnt/β-catenin signaling
- Cytotoxic therapy-induced effects on both hematopoietic and marrow stromal cells promotes therapy-related myeloid neoplasms
- Single-cell omics in ageing: a young and growing field
- Selective autophagy in normal and malignant hematopoiesis
- Non-amyloid approaches to disease modification for Alzheimer’s disease: an EU/US CTAD Task Force Report
- Effect of enhancer of zeste homolog 2 mutations on the prognosis of patients with myelodysplastic syndrome: A meta-analysis
- EZH2 in myeloid malignancies
- In vivo gene editing of muscle Stem cells with adeno-associated viral vectors in a mouse model of Duchenne muscular dystrophy
- Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans
- CXCR4 signaling has a CXCL12-independent essential role in murine MLL-AF9-driven acute myeloid leukemia
- Skeletal muscle in health and disease
- The complex role of EZH2 in the tumor microenvironment: opportunities and challenges for immunotherapy combinations
- Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis
- A germ cell ‐specific ageing pattern in otherwise healthy men
- Moderation of mitochondrial respiration mitigates metabolic syndrome of aging
- Aging, obese-insulin resistance, and bone remodeling
- Stochastic non-enzymatic modification of long-lived macromolecules-a missing hallmark of aging
- The Science Behind NMN–A Stable, Reliable NAD+ Activator and Anti-Aging Molecule
- Progress in elucidation of molecular pathophysiology of myeloproliferative neoplasms and its application to therapeutic decisions
- Narcissus tazetta bulb extract delays cellular senescence by reducing mTOR pathway activation
- A Distinct Subset of Human Blood Stem Cells Resists Regenerative Stress to Preserve Stemness
- TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis
- Targeting senescent cells for a healthier aging: challenges and opportunities
- High-dimensional single-cell quantitative profiling of skeletal muscle cell population dynamics during regeneration
- cell Therapy for Idiopathic Pulmonary Fibrosis: Rationale and Progress to Date
- Regulation of normal and malignant hematopoiesis by FBOX Ubiquitin E3 Ligases
- TLR2/6 signaling promotes the expansion of premalignant hematopoietic Stem and progenitor cells in the NUP98–HOXD13 mouse model of MDS
- Tailored chromatin modulation to promote tissue regeneration
- Aging-related molecular pathways in chronic cholestatic conditions
- Frailty, physical function and affective status in elderly patients on hemodialysis
- Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan
- Aging: therapeutics for a healthy future
- The aryl hydrocarbon receptor (AhR) in the aging process: another puzzling role for this highly conserved transcription factor
- Effects of the tetrahedral framework nucleic acids on the skeletal muscle regeneration in vitro and in vivo
- Environmental Oxygen is a Key Modulator of Development and Evolution: From Molecules to Ecology: Oxygen‐sensitive pathways pattern the developing organism …
- TLR engagement induces ARID3a in human blood hematopoietic progenitors and modulates IFNα production
- Clinical significance of chemokine receptor antagonists
- Impaired Regeneration in Dystrophic Muscle—New Target for Therapy
- Controlling syStemic inflammation by careful formulation of topical skin care products: our bodies didn’t evolve with all the current chemicals in skin care products
- Cellular and molecular mechanisms of environmental pollutants on hematopoiesis
- Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
- Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy
- Social hallmarks of aging: Suggestions for geroscience research
- Rbm24 modulates adult skeletal muscle regeneration via regulation of alternative splicing
- Frailty, a multisyStem ageing syndrome
- Hematopoietic Stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia
- Bacterial lipopolysaccharides suppress erythroblastic islands and erythropoiesis in the bone marrow in an extrinsic and G-CSF-, IL-1-, and TNF-independent …
- Major depressive disorder and accelerated aging from a peripheral IGF-1 overexpression perspective
- Platelets in aging and cancer—“double-edged sword”
- The world goes bats: living longer and tolerating viruses
- Tissue engineering and regenerative medicine therapies for cell senescence in bone and cartilage
- Cytological evaluation of enlarged peripheral lymph nodes: An institutional experience from kumaon region of Uttarakhand
- Physical exercise as an immunomodulator of chronic diseases in aging
- Cellular stress responses and dysfunctional Mitochondrial–cellular senescence, and therapeutics in chronic respiratory diseases
- Genetics of frailty: A longevity perspective
- The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype
- Risk Prediction Model Development for Late On-Set Breast Cancer Screening in Low-and Middle-Income Societies: A Model Study for North Cyprus
- The self-fulfilling prophecy of pulmonary fibrosis: a selective inspection of pathological signalling loops
- Regulatory role of exercise-induced autophagy for sarcopenia
- Understanding Bone Marrow Interactions Which Drive Aging of Hematopoietic Stem Cells
- Mechanisms and origins of spinal pain: from molecules to anatomy, with diagnostic clues and imaging findings
- CRISPR‐Cas9–induced IGF1 gene activation as a tool for enhancing muscle differentiation via multiple isoform expression
- Understanding Bone Marrow Interactions w\hich Drive Aging of Hematopoietic Stem Cells
- Methionine dependence of cancer
- A survey of essential genome stability genes reveals that replication stress mitigation is critical for peri-implantation embryogenesis
- Impact of Epigenetics on Complications of Fanconi Anemia: The Role of Vitamin D-Modulated Immunity
- Exosomes can Regenerate Your Stem Cells
- Bioinformatics-Based Study to Investigate Potential Differentially Expressed Genes and miRNAs in Pediatric Sepsis
- BMAL1 Modulates Epidermal Healing in a Process Involving the Antioxidative Defense Mechanism
- Wwox deficiency causes downregulation of prosurvival ERK signaling and abnormal homeostatic responses in mouse skin
- Role of age-related mitochondrial dysfunction in sarcopenia
- The biphasic and age-dependent impact of Klotho on hallmarks of aging and skeletal muscle function
- Bone Marrow Failure Disorders in the Adolescent Female
- Senescence and cancer: a review of clinical implications of senescence and senotherapies
- Pivotal role of DPYSL2A in KLF4-mediated monocytic differentiation of acute myeloid leukemia cells
- An immune-cell signature of bacterial sepsis
- Role of senescence and neuroprotective effects of telomerase in neurodegenerative diseases
- The biology of aging and cancer: a complex association
- Aging-related changes in the gene expression profile of human lungs
- Epidemiology and risk factors of chronic obstructive pulmonary disease in Suzhou: a population-based cross-sectional study
- The genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance
- Aging fits the disease criteria of the International Classification of Diseases
- Recent advances in the treatment of osteoarthritis
- Calorie restriction and aging in humans
- The MLL/SET family and haematopoiesis
- Acute Kidney Injury and Cytokines
- ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly
- Sclerostin and vascular pathophysiology
- Overfeeding and Substrate Availability, But Not Age or BMI, Alter Human Satellite cell Function
- Integrin-mediated adhesions in regulation of cellular senescence
- MicroRNAs, DNA damage response and ageing
- Insights into the conserved regulatory mechanisms of human and yeast aging
- Mitochondrial Priming of Tumor Initiating Cells Involves Repression of Mitochondrial Fission Activity Towards Redox Regulation of the cell Cycle Regulator Cyclin E
- Runx1 Gene in Acute Myeloid Leukemia: Expression Level Significance and Impact on Clinical Features
- circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan
- Aryl hydrocarbon receptor connects dysregulated immune cells to atherosclerosis
- 1, 25‐Dihydroxyvitamin D protects against age‐related osteoporosis by a novel VDR‐Ezh2‐p16 signal axis
- Endothelial mTOR maintains hematopoiesis during aging
- POGLUT1 biallelic mutations cause myopathy with reduced satellite cells, α-dystroglycan hypoglycosylation and a distinctive radiological pattern
- Model-based inference and classification of immunologic control mechanisms from TKI cessation and dose reduction in patients with CML
- Evaluation via supervised machine learning of the broiler pectoralis major and liver transcriptome in association with the muscle myopathy wooden breast
- Sustained fetal hematopoiesis causes juvenile death from leukemia: evidence from a dual-age–specific mouse model
- Cellular senescence and Alzheimer disease: the egg and the chicken scenario
- Frailty as a phenotypic manifestation of underlying oxidative stress
- Neuronal mechanisms that drive organismal aging through the lens of perception
- Influence of Casein kinase II inhibitor CX-4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo
- The role of cellular senescence in ageing and endocrine disease
- The Role of Nrf2 in Brain Cellular Senescence
- Mitophagy and mitochondrial dysfunction in cancer
- Muscle, bone, and fat crosstalk: the biological role of myokines, osteokines, and adipokines
- Lung epithelium damage in COPD–an unstoppable pathological event?
- Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy
- Age‐related factors that affect B cell responses to vaccination in mice and humans
- Pro-senescence and anti-senescence mechanisms of cardiovascular aging: cardiac MicroRNA regulation of longevity drug-induced autophagy
- Epigenetic clock measuring age acceleration via DNA methylation levels in blood is associated with decreased oocyte yield
- Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression
- Integrating the Science of Aging and Environmental Health Research
- Autophagy‐Sirt3 axis decelerates hematopoietic aging
- Iron and physical activity: Bioavailability enhancers, properties of black pepper (bioperine®) and potential applications
- DNA Damage and the Maintenance of Nuclear Genome Integrity in Aging and Associated Phenotypes
- Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease
- Hepatic stellate cell –specific knockout of transcriptional intermediary factor 1γ aggravates liver fibrosis
- Effect of age on the cardiovascular remodelling induced by chronic intermittent hypoxia as a murine model of sleep apnoea
- Integration Analysis of Differential Expressed Genes Regulated by Differential Methylated Regions for Predicting Prognosis in Human Colon Cancer
- Influence of aging on deterioration of patients with COVID-19
- Gene co-expression network for analysis of plasma exosomal miRNAs in the elderly as markers of aging and cognitive decline
- Anti-aging role of Chinese herbel medicine: an overview of scientific evidence from 2008 to 2018
- The secretory senescence of the airway
- Pathogenesis of aging and age-related comorbidities in people with HIV: highlights from the HIV ACTION workshop
- The information theory of aging: Hacking immortality?
- DNA Repair in the Development of Human Diseases and Therapy
- Limiting Self-Renewal of the Basal Compartment Induces Differentiation and Alters Evolution of Mammary Tumors
- The BDNF rs6265 Polymorphism is a Modifier of Cardiomyocyte Contractility and Dilated Cardiomyopathy
- The genetics of human ageing
- Epigenetic changes during ageing and their underlying mechanisms
- Frailty prevalence and agreement between assessment tools in elderly patients of Western India
- ISLR regulates skeletal muscle atrophy via IGF1-PI3K/Akt-Foxo signaling pathway
- Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs
- Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain
- Senotherapy: a new horizon for COPD therapy
- Trajectories of aging: how syStems biology in yeast can illuminate mechanisms of personalized aging
- Limiting self-renewal of the basal compartment by PKA activation induces differentiation and alters the evolution of mammary tumors
- MiR-199-3p modulates the onset of puberty in rodents probably by regulating the expression of Kiss1 via the p38 MAPK pathway
- Hexokinase 2 promotes cell growth and tumor formation through the Raf/MEK/ERK signaling pathway in cervical cancer
- Brain endothelial cells are exquisite sensors of age-related circulatory cues
- Nrf2 in early vascular ageing: Calcification, senescence and therapy
- Clearing techniques for visualizing the nervous syStem in development, injury, and disease
- Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges
- Immortality, Inc.: Renegade Science, Silicon Valley Billions, and the Quest to Live Forever
- Designing neuroreparative strategies using aged regenerating animal models
- Syndrome of persistent inflammation, the immune suppression and catabolism in surgery
- Emerging therapeutic targets for osteoporosis
- Mitochondria, aging, and cellular senescence: implications for scleroderma
- Impact of Bariatric Surgery on Circulating Inflammatory and Pro-vascular Progenitor cell Populations
- Insights into the role of bioactive food ingredients and the microbiome in idiopathic pulmonary fibrosis
- A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson’s disease in older people: An EXosomes in PArkiNson Disease (EXPAND) …
- Obesity and ageing: Two sides of the same coin
- Aging and age-related health effects of ionizing radiation
- Heterogeneity and overlaps in nucleotide excision repair disorders
- Noncoding RNAs controlling telomere homeostasis in senescence and aging
- The Function of the Long Noncoding RNA Growth Arrest Specific 5 in Hematopoietic Stem and Progenitor Cells
- Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases
- The Expression Levels of Klotho, Endothelial Nitrite Oxide Synthetase and Catalase Genes of the Heart Tissues of Young and Old Rats/Genc ve Yasli Ratlarin Kalp …
- Analysis of transcriptional modules during human fibroblast ageing
- Pathobiology of frailty in lung disease
- The enigma of excessively long telomeres in cancer: lessons learned from rare human POT1 variants
- Turning the oxygen dial: balancing the highs and lows
- A Computational Perspective at the Histone Modification Landscape of the Mouse Liver During Aging
- The involvement of stress granules in aging and aging‐associated diseases
- Conditioning Medicine
- Cellular senescence in arterial diseases
- RNA and aging
- Inherited disorders of lysosomal membrane transporters
- Advancements in therapeutic drugs targeting of senescence
- Cellular senescence in kidney fibrosis: Pathologic significance and therapeutic strategies
- The value of imaging and composition-based biomarkers in Duchenne muscular dystrophy clinical trials
- Immortality, Inc: Renegade Scientists, Silicon Valley Gurus, and the Future of Cheating Death
- Regulating methylation at H3K27: a trick or treat for cancer cell plasticity
- OPINION Open Access
- The road ahead for health and lifespan interventions
- Multi-omics network analysis reveals distinct stages in the human aging progression in epidermal tissue
- Epigenetic biomarkers for human sepsis and septic shock: insights from immunosuppression
- Age related changes in the expression of tenascin-c in liver of albino rat
- The role of reactive oxygen species in tumor treatment and its impact on bone marrow hematopoiesis
- Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging
- Attempts to Quantify Mitochondrial DNA Deletions in Single Drosophila melanogaster Flies
- A Bayesian data fusion based approach for learning genome-wide transcriptional regulatory networks
- Effects of Low Dose Ionizing Radiation on DNA Damage and Repair Response in Proliferating Muscle Stem Cells
- Extracellular vesicles: recent developments in aging and reproductive diseases
- PKCθ as a target to manipulate satellite cell function
- page Hepatic stellate cell -specific knockout of transcriptional intermediary factor 1γ aggravates liver fibrosis
- Synthetic immunomodulation with a CRISPR super-repressor in vivo
- Telomere damage induces internal loops that generate telomeric circles
- Recent advances and possibilities for the use of plant phenolic compounds to manage ageing-related diseases
- Targeting miRNAs by polyphenols: Novel therapeutic strategy for aging
- Chronic lower extremity ischemia and its association with the frailty syndrome in patients with diabetes
- Inter-organelle membrane contact sites and mitochondrial quality control during aging: A geroscience view
- Unveiling the role of inflammation and oxidative stress on age-related cardiovascular diseases
- Sleep and ageing: from human studies to rodent models
- Protein Structure and Function in Aging and Age-Related Diseases
- Strategies to improve participation of older adults in cancer research
- Mitochondrial MicroRNAs in aging and neurodegenerative diseases
- NADPH oxidase inhibition in fibrotic pathologies
- Ovarian aging increases small extracellular vesicle CD81+ release in human follicular fluid and influences miRNA profiles
- Nutrition in Cancer Therapy in the Elderly—An Epigenetic Connection?
- Exosome-mediated hematopoietic rejuvenation in a humanized mouse model indicate potential for cancer immunotherapy
- Wnt signaling mediates TLR pathway and promote unrestrained adipogenesis and metaflammation: therapeutic targets for obesity and type 2 diabetes
- The Role of Mutant DNMT3a in Ageing and in the Regulation of Normal and Malignant Haematopoiesis
- Hypoxia-induced degenerative protein modifications associated with aging and age-associated disorders
- Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway
- SyStematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age
- The sciences of healthy aging await a theory of health
- Respiratory Organ Aging and Cancer
- Epigenetics and ageing
- Determinants of accelerated metabolomic and epigenetic aging in a UK cohort
- STRESS & ACCELERATED AGING
- Characterization of blood markers and their implication in human aging.
- The gut microbiome, aging, and longevity: a syStematic review
- The Evi5 oncogene promotes laryngeal cancer cells proliferation by stabilizing c-Myc protein
- Whole-genome sequencing of rare disease patients in a national healthcare syStem
- Association between Nrf2 and CDKN2A expression in patients with end-stage renal disease: a pilot study
- Transposable elements, circular RNAs and mitochondrial transcription in age-related genomic regulation
- The transcriptional regulation by MYSM1 in hematopoietic Stem and progenitor cells
- Prevalence and risk factors of chronic obstructive pulmonary disease among Agriculturists in a rural community, central Thailand
- Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease
- Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
- Protective mechanisms against DNA replication stress in the nervous syStem
- Trained Immunity at a Glance; A Review on the Innate Immune Memory and its Potential Role in Infections, Diseases and New Therapeutic Strategies
- Metformin: An old drug against old age and associated morbidities
- Edible flowers as functional raw materials: A review on anti-aging properties
- Location, location, location: how vascular specialization influences hematopoietic fates during development
- Type I interferon (IFN)-regulated activation of canonical and non-canonical signaling pathways
- Transplantation of marginal organs: immunological aspects and therapeutic perspectives in kidney transplantation
- CDK7 mediates the beta-adrenergic signaling in thermogenic brown and white adipose tissues
- Amelioration of age‐related brain function decline by Bruton’s tyrosine kinase inhibition
- Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos
- Perioperative care of geriatric patients
- Male age and andropause
- CDK7 regulates organ size and tumor growth by safeguarding the Hippo pathway effector Yki/Yap/Taz in the nucleus
- Recent advances in the treatment of osteoarthritis
- Ageing, age-related diseases and oxidative stress: what to do next?
- Mechanisms of aging and potential role of selected polyphenols in extending healthspan
- Dietary antioxidants, epigenetics, and brain aging: A focus on resveratrol
- From Fruit Flies to the Frontline: Slow Science in a Demanding Medical Climate
- The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging
- Mechanisms of aging and the preventive effects of resveratrol on age-related diseases
- Structural features of nucleoprotein CST/shelterin complex involved in the telomere maintenance and its association with disease mutations
- Male Age and Andropause 36
- Why we should use topological data analysis in ageing: towards defining the “topological shape of ageing”
- Active Peptide KF-8 from Rice Bran Attenuates Oxidative Stress in a Mouse Model of Aging Induced by d-Galactose
- The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its essential role in neurodevelopment and aging
- Crosstalk of Molecular Signaling in Hepatocellular Carcinoma
- Curcumin in age-related diseases
- Biological aging and the cellular pathogenesis of Huntington’s disease
- Small‐molecule inhibition of aging‐associated chromosomal instability delays cellular senescence
- Platelet activation is triggered by factors secreted by senescent endothelial HMEC-1 cells in vitro
- Air space distension precedes spontaneous fibrotic remodeling and impaired cholesterol metabolism in the absence of surfactant protein C
- Frailty, cognition, and falls
- Alternative pathways of IL-1 activation, and its role in health and disease
- CXCL12-CXCR4 Interplay Facilitates Palatal Osteogenesis in Mice
- Mouse models for muscular dystrophies: an overview
- Extra virgin olive oil polyphenols: Modulation of cellular pathways related to oxidant species and inflammation in aging
- Resveralogues: from novel ageing mechanisms to new therapies?
- NMR-based metabonomic analysis of HUVEC cells during replicative senescence
- Molecular Biomarkers of Aging Studies in Humans
- Research progress of mTOR inhibitors
- Testing Sulforaphane for Chemoprevention Against Ageing and Functional Decline in Male Drosophila Models
- Characterization of Genome-Wide Binding of Nuclear-Factor IX in Hematopoietic Progenitor Cells
- CDK7 inhibitors in cancer therapy: the sweet smell of success?
- Discovery of Senolytics and the Pathway to Early Phase Clinical Trials
- Circular RNAs: New players in Ageing and Age-related Chronic Disease
- Circulating cell -free DNA is predominantly composed of retrotransposable elements and non-telomeric satellite DNA
- A preliminary study to investigate the genetic background of longevity based on whole-genome sequence data of two Methuselah dogs
- Aging: a new perspective on an old issue
- Nicotinamide, a poly [ADP-ribose] polymerase 1 (PARP-1) inhibitor, as an adjunctive therapy for the treatment of Alzheimer’s disease
- Age estimation using DNA methylation technique in forensics: a syStematic review
- Does Diet Have a Role in the Treatment of Alzheimer’s Disease?
- Human CTC1 promotes TopBP1 stability and CHK1 phosphorylation in response to telomere dysfunction and global replication stress
- Cyclin-dependent kinase 7 inhibitors in cancer therapy
- Interplay between aging, lung inflammation/remodeling, and fibronectin EDA in lung cancer progression
- Consequences of cell fusion and multinucleation for skeletal muscle development and disease
- The role of Sestrins in the regulation of the aging process
- Redox signalling and ageing: insights from Drosophila
- Accelerating the search for interventions aimed at expanding the health span in humans: the role of epidemiology
- Age-related changes in haematological parameters and biochemical markers of healing in the stomach of rats with acetic acid induced injury
- Flexibility is costly: hidden physiological damage from seasonal phenotypic transitions in heterothermic species
- Mitochondrial Function in Aging
- Oxidative Stress and Dietary Antioxidants in Neurological Diseases
- THE IMMORTALITY IMPULSE AND JEWISH TRADITION
- Anti-cancer Dynamics of Natural Phytochemical Inhibitors of Cyclin-Dependent Kinases
- Searching for the mechanisms of mammalian cellular aging through underlying gene regulatory networks
- Ribosome, protein synthesis, and aging
- Understanding the heterogeneity of senescence and ageing at the single-cell level
- EVI5 is an oncogene that regulates the proliferation and metastasis of NSCLC cells
- CDK7 inhibition potentiates genome instability triggering anti-tumor immunity in small cell lung cancer
- Still living better through chemistry: An update on caloric restriction and caloric restriction mimetics as tools to promote health and lifespan
- Changes in RNA regulatory processes during mammalian ageing
- Time-restricted feeding prolongs lifespan in Drosophila in a peripheral clock-dependent manner
- Telomeres and telomere length: a general overview
- The relationship between nutrients and biological aging
- Investigating the Role of CDK11 in Animal Cytokinesis
- Investigating the Effects of Lestaurtinib on Skeletal Muscle Regeneration
- Macrophage immunometabolism and inflammaging: roles of mitochondrial dysfunction, cellular senescence, CD38, and NAD
- The study of transcription factors SCL and LYL1 in normal and malignant haematopoiesis
- Sarcoplasmic reticulum Ca2+ dynamics in aging Drosophila and correlation with sarcopenia
- Calcium-activated potassium channels: Implications for aging and age-related neurodegeneration
- Isolated Congenital Asplenia (ICA) and Mutations in RPSA
- eIF2B extends lifespan through inhibition of the integrated stress response
- Interleukin-21 Deficiency
- Implications of Chronic Infection on Skeletal Muscle Immunity, Regeneration, and Function
- Current nutritional and pharmacological anti-aging interventions
- Psychological Stress and Breast Cancer
- Idiopathic interstitial pneumonias
- The Epigenome of Aging
- Stress influence in neurodegeneration. Unravelling the mechanisms underlying stress response in brain ageing by 11ß-HSD1 inhibition
- Vacuolar transporter Mnr2 safeguards mitochondrial integrity in aged cells
- Interstitial lung diseases in children
- Gut microbiota and old age: Modulating factors and interventions for healthy longevity
- Epigenetics in Exercise
- Resetting proteostasis with ISRIB prevents pulmonary fibrosis
- Semelparity and Reproductive Death in Caenorhabditis elegans
- Evolution and treatment of idiopathic pulmonary fibrosis
- 20 Biological Rhythms and Aging
- The Role of SOX2 in Regulating Metabolism and Enzalutamide Resistance in Prostate Cancer
- CENTER HEARTBEAT
- MRE11-Dependent Instability in Mitochondrial DNA Fork Protection Activates cGAS Inflammation
- Beyond host defense: Deregulation of Drosophila immunity and age-dependent neurodegeneration
- Biological Rhythms and Aging
- Aus dem Institut für Arbeits-, Sozial-und Umweltmedizin der Heinrich-Heine-Universität Düsseldorf Direktor: Univ.-Prof. Dr. Peter Angerer
- Genetic epidemiology of markers of genomic ageing
- The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia
- Spatiotemporal changes in the human lens proteome: Critical insights into long-lived proteins
- The Role of the Circadian Clock in Hippocampal Aging and as a Therapeutic Target in Alzheimer’s Disease
- Dissecting Dystrophin’s Roles, Subcellular Organization, and Functional Network in Drosophila Oogenesis
- Klotho, aging, and the failing kidney
- From Mice to Humans: An Overview of the Potentials and Limitations of Current Transgenic Mouse Models of Major Muscular Dystrophies and Congenital Myopathies
- The crossroad of phosphatase and kinase signaling in cancer
- Deciphering the mechanism of adult reproductive diapause in C. elegans
- Precision modeling of breast cancer in the CRISPR era
- A RecQ helicase in disguise: Characterization of the unconventional Structure and Function of the human Genome Caretaker RecQ4
- Peanut Protein Supplemenation to Augment Muscle Growth and Improve Markers of Muscle Quality and Health in Older Individuals
- The chemical exposome of human aging
- Spontaneous replication fork collapse regulates telomere length homeostasis in wild type cells
- Investigating neuroregulation of sebaceous gland biology
- Oxidative modification of SOD1 as a mechanism of pathological aging
- The parasitic worm product ES-62 promotes health-and life-span in a high calorie diet-accelerated mouse model of ageing
- Dysregulation of the glutaredoxin/S-glutathionylation redox axis in lung diseases
- Obesity: A Bad Partner for the Elderly
- Longevity: translation of aging theories into action
- Modifying the proteostasis status: the role of cross-organelle communication
- Characterisation of senescence entry point using long-lived mutants and intervention related to ageing factors ERC and ROS
- Age-dependent effects of short-term intermittent fasting and rapamycin treatment in zebrafish (danio rerio) brain
- The Fanconi Anaemia Group M (FANCM) Protein and Its Binding Partner FAAP24 Modulate ALT Telomere Maintenance in Human Cells
- Age-dependent effects of short-term intermittent fasting and rapamycin treatment in Zebrafish (Danio Rerio) brain
- High dose intra-venous Vitamin C administration to prevent mortality in patients with sepsis: A Randomized, Double-blind, Placebo-controlled trial
- Examining the Role of Microglia in Niemann-Pick Type C
- Contribution of histone modifications to double-strand break repair and aging
- Loco-Regional Treatment of Cutaneous Melanoma
- Genetic code expansion for ageing study
- Measurement of Biological Age in Humans: Approach, Comparability, and Critical Perspective
- Novel functional domains in the muscle disease associated protein KY
- Epigenetics of Schizophrenia and Suicidality
- Investigating the Regulation of Ras Signalling by ROS in Caenorhabditis elegans
- Coevolution of sociality and ageing in animal societies
- Hallmarks of aging in kidney from mice submitted to genetic and nutritional intervention
- Sex-differences shape memory capacity declining during ageing: rescue effects of voluntary exercise
- Escape of hair follicle Stem cells causes Stem cell exhaustion during aging
- Enhanced autophagy in Becn1F121A/F121A knockin mice counteracts aging-related neural Stem cell exhaustion and dysfunction
- Arabidopsis casein kinase 2 triggers Stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway
- Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging
- FANCD2 and HES1 suppress inflammation‐induced PPARɣ to prevent haematopoietic Stem cell exhaustion
- Is Avoiding Stem cell exhaustion the New Therapeutic Approach in Colitis?
- TNFα Controls the Delicate Balance between Erythropoiesis and Stem cell exhaustion during Inflammatory Stress
- Epigenetic alterations in Stem cell ageing—a promising target for age-reversing interventions?
- FAM122A is required for hematopoietic Stem cell function
- Application of mesenchymal Stem cell therapy for aging frailty: From mechanisms to therapeutics
- Sestrins regulate muscle Stem cell metabolic homeostasis
- A Review of the Impact of Calorie Restriction on Stem cell Potency
- Arabidopsis casein kinase 2 triggers Stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway
- Strategies to Protect Hematopoietic Stem Cells from Culture-induced Stress Conditions.
- Mitochondrial Contributions to Hematopoietic Stem cell Aging
- cell size is a determinant of Stem cell potential during aging
- cell and cell -Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to Light
- Metabolic Coordination of Stem cell Fate Controls Tumor Initiation and Tissue Repair
- Immune reconstitution in the aging host: Opportunities for mechanism-based therapy in allogeneic hematopoietic cell transplantation
- Ageing human bone marrow mesenchymal Stem cells have depleted NAD (P) H and distinct multispectral autofluorescence
- Prolonged maintenance of hematopoietic Stem cells that escape from thrombopoietin deprivation
- mTOR signaling as a regulator of hematopoietic Stem cell fate
- Healthy ageing and spermatogenesis
- Mitochondria as signaling organelles control mammalian Stem cell fate
- Meloxicam with Filgrastim may Reduce Oxidative Stress in Hematopoietic Progenitor Cells during Mobilization of Autologous Peripheral Blood Stem Cells in Patients …
- Opportunities and challenges in Stem cell aging
- Cryptomphalus aspersa Eggs Extract Potentiates Human Epidermal Stem cell Regeneration and Amplification
- ESC-sEVs rejuvenate aging hippocampal NSCs by transferring SMADs to regulate the MYT1-Egln3-Sirt1 axis
- Mesenchymal Stem cell Transplantation for the Treatment of Cognitive Frailty
- Functional genomics of ageing: implications of chromatin landscape and beyond
- Inflammation, a common mechanism in frailty and COVID‐19, and Stem cells as a therapeutic approach
- Impact of Selenium on Biomarkers and Clinical Aspects Related to Ageing. A Review
- Aging delays epimorphic regeneration in mice
- Rejuvenation of senescent bone marrow mesenchymal stromal cells by pulsed triboelectric stimulation
- Crosstalk among DNA Damage, Mitochondrial Dysfunction, Impaired Mitophagy, Stem cell Attrition, and Senescence in the Accelerated Ageing Disorder Werner …
- Muscle Stem cell quiescence: controlling Stemness by staying asleep
- Mediterranean diet and the hallmarks of ageing
- Antioxidant effects of caffeic acid lead to protection of drosophila intestinal Stem cell aging
- Generation of new in vivo tools to study healthy and pathological aging of the nervous syStem
- Pharmacological and non-pharmacological interventions for aging
- Metabolism and chromatin: A dynamic duo that regulates development and ageing: Elucidating the metabolism‐chromatin axis in bone‐marrow mesenchymal Stem …
- Prognostic impact of serum CXC chemokine ligands 4 and 7 on myelodysplastic syndromes post allogeneic hematopoietic cell transplant
- Hair Follicle Stem cell Regeneration in Aging
- Late/post-term decidual basalis-derived mesenchymal Stem/stromal cells show evidence of advanced ageing and downregulation of microRNA-516b-5p
- Clonal Hematopoiesis Driven By MDM4 Amplification Defines a Canonical Route Towards Secondary MDS/AML in Fanconi Anemia Patients
- Intracrine Vascular Endothelial Growth Factor Maintains Hippocampal Neural Stem cell Quiescence
- Mediterranean diet and the hallmarks of ageing
- Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis
- Calcium signaling as an integrator and decoder of niche factors to control somatic Stem cell quiescence and activation
- The antiaging role of oxytocin
- Theories of Stem cell aging
- Hematopoietic Stem cell (HSC) divisional memory: The journey of mitochondrial metabolism through HSC division
- Balancing DNA repair to prevent ageing and cancer
- Clinical features, pathophysiology and therapy of Poor Graft Function Post Allogeneic Stem cell Transplantation
- New insights of epigenetics in vascular and cellular senescence
- Isolation and characterization of neural Stem/progenitor cells in the subventricular zone of the naked mole-rat brain
- Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem cell Metabolism
- Hematopoietic versus leukemic Stem cell quiescence: Challenges and therapeutic opportunities
- Cancer treatment-induced accelerated aging in cancer survivors: biology and assessment
- Nutrition and the Hallmarks of Aging
- Aging-induced Stem cell dysfunction: Molecular mechanisms and potential therapeutic avenues
- IL-10–producing innate lymphoid cells increased in patients with house dust mite allergic rhinitis following immunotherapy
- Periodontitis and Accelerated Biological Aging: A Geroscience Approach
- Single or Repeated Ablation of Mouse Olfactory Epithelium by Methimazole
- Epigenetic and metabolic regulation of epidermal homeostasis
- Aging and hematopoiesis
- Dermal Pericytes Exhibit Declined Ability to Promote Human Skin Regeneration with Ageing in 3D Organotypic Culture Models
- Srebf1c preserves hematopoietic Stem cell function and survival as a switch of mitochondrial metabolism
- Stem‐cell ‐based therapies for retinal degenerative diseases: Current challenges in the establishment of new treatment strategies
- Persistent NF-κB activation in muscle Stem cells induces proliferation-independent telomere shortening
- Taurine represses age‐associated gut hyperplasia in Drosophila via counteracting endoplasmic reticulum stress
- Why Stem/progenitor cells lose their regenerative potential
- Advances in preclinical hematopoietic Stem cell models and possible implications for improving therapeutic transplantation
- OGT regulates hematopoietic Stem cell maintenance via PINK1-dependent mitophagy
- Epigenetic plasticity and redox regulation of neural Stem cell state and fate
- Empowering muscle Stem cells for the treatment of Duchenne muscular dystrophy
- Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis
- Data on RNA-seq analysis of Drosophila melanogaster during ageing
- Treatment-Free Remission: the New Goal in CML Therapy
- Stem cell aging and wound healing
- Immunity, Stem cells, and aging
- Muscle Stem cell adaptations to cellular and environmental stress
- ATP-dependent chromatin remodelers in ageing and age-related disorders
- The Future of Pensions and Life Extension
- The tumor suppression theory of aging
- Unraveling the Big Sleep: Molecular Aspects of Stem cell Dormancy and Hibernation
- CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis
- The potential of calorie restriction and calorie restriction mimetics in delaying aging: focus on experimental models
- Neural Stem cell -derived extracellular vesicles counteract insulin resistance-induced senescence of neurogenic niche
- Cytokine combinations for human blood Stem cell expansion induce cell -type–and cytokine-specific signaling dynamics
- Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling
- ATM modulates subventricular zone neural Stem cell maintenance and senescence through Notch signaling pathway
- Transcriptional and epigenetic control of hematopoietic Stem cell fate decisions in vertebrates
- TWIST1 preserves hematopoietic Stem cell function via the CACNA1B/Ca2+/mitochondria axis
- Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age
- Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal Stem cell population
- Impact of selenium on biomarkers and clinical aspects related to ageing. A review
- N1-acetylspermidine is a determinant of hair follicle Stem cell fate
- Stem cell quiescence: the challenging path to activation
- Cancer Treatment-Induced Accelerated Aging in Cancer Survivors: Biology and Assessment. Cancers 2021, 13, 427
- Chaperone-mediated autophagy sustains haematopoietic Stem–cell function
- Stem cell rejuvenation by restoration of youthful metabolic compartmentalization
- Aging and Stem cell renewal
- The aryl hydrocarbon receptor modulates murine hematopoietic Stem cell homeostasis and influences lineage-biased Stem and progenitor cells
- Dynamic regulation of mitochondrial-endoplasmic reticulum crosstalk during Stem cell homeostasis and aging
- Hair-Follicle Mesenchymal Stem cell Activity during Homeostasis and Wound Healing
- Metabolic Regulation of Stem Cells in Aging
- Targeting impaired adult hippocampal neurogenesis in ageing by leveraging intrinsic mechanisms regulating Neural Stem cell activity
- The AGE Presents Introduction to Geroscience video lecture series
- Age-Related Metabolic Pathways Changes in Dental Follicles: A Pilot Study
- The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic Stem cell function
- CD63 acts as a functional marker in maintaining hematopoietic Stem cell quiescence through supporting TGFβ signaling in mice
- Pharmacological Inhibition of p38 MAPK Rejuvenates Bone Marrow Derived-Mesenchymal Stromal Cells and Boosts their Hematopoietic Stem cell -Supportive Ability
- Peptidylarginine deiminase IV (PADI4) is not essential for cell -autonomous HSC maintenance and normal haematopoiesis
- Dental pulp Stem cell -derived small extracellular vesicle in irradiation-induced senescence
- Epimorphic regeneration of the mouse digit tip is finite
- Epithelial Stem cell homeostasis in Meibomian gland development, dysfunction, and dry eye disease
- Acute intestinal inflammation depletes/recruits histamine-expressing myeloid cells from the bone marrow leading to exhaustion of MB-HSCs
- Differential regulation of β-catenin-mediated transcription via N-and C-terminal co-factors governs identity of murine intestinal epithelial Stem cells
- The Impact of Sedentary Lifestyle, High-fat Diet, Tobacco Smoke, and Alcohol Intake on the Hematopoietic Stem cell Niches
- Role of biological markers in Stem cell aging and its implications in therapeutic processes
- IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock
- Wnt Signaling Rescues Amyloid Beta-Induced Gut Stem cell Loss
- Stabilization of heterochromatin by CLOCK promotes Stem cell rejuvenation and cartilage regeneration
- DNA Damage-Induced Inflammatory Microenvironment and Adult Stem cell Response
- Metabolic Control of Stem cell Ageing and Longevity through Caloric Restriction
- Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer …
- Effects of caloric restriction on the antagonistic and integrative hallmarks of aging
- Hormetic ER Stress in Hematopoietic Stem Cells
- Advantages and challenges of Stem cell therapy for osteoarthritis
- NAP1L2 drives mesenchymal Stem cell senescence and suppresses osteogenic differentiation
- Accelerated lung aging in COPD: finding potential anti-aging therapies
- Enhanced germline Stem cell longevity in Drosophila diapause
- A comprehensive transcriptome signature of murine hematopoietic Stem cell aging
- Is Myelodysplasia a Consequence of Normal Aging?
- The central role of DNA damage in the ageing process
- Epithelial Stem cells at the intersection of tissue regeneration and pulmonary fibrosis
- The FOXO signaling axis displays conjoined functions in redox homeostasis and Stemness
- Yin and Yang: The dual effects of interferons on hematopoiesis
- Lipid metabolism in focus: how the build-up and breakdown of lipids affects Stem cells
- Hematopoiesis, Inflammation and Aging—The Biological Background and Clinical Impact of Anemia and Increased C-Reactive Protein Levels on Elderly Individuals
- Metabolic and Redox regulation of cardiovascular Stem cell biology and pathology
- Control of satellite cell function in muscle regeneration and its disruption in ageing
- The Yin and Yang of Immunity in Stem cell Decision Guidance in Tissue Ecologies: An Infection Independent Perspective
- Mechanisms of adipose-derived Stem cell aging and the impact on therapeutic potential
- Cyclin‐Dependent Kinase 4 expression alters the number of keratinocyte Stem cells in the mouse hair follicle
- A comprehensive transcriptome signature of murine hematopoietic Stem cell aging
- An NRF2 perspective on Stem cells and ageing
- Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle Stem cell functionality
- Disqueratosis congénita y absceso del siStema nervioso central
- Inflammation, aging and hematopoiesis: A complex relationship
- Phenotypical changes of hematopoietic Stem and progenitor cells in sepsis patients: correlation with immune status?
- Interpreting Geroscience-Guided Biomarker Studies
- The Act of controlling adult Stem cell dynamics: insights from animal models
- Regulation of spermatogenic Stem cell homeostasis by mitogen competition in an open niche microenvironment
- CDK19 regulates the proliferation of hematopoietic Stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21
- Inherited DNA repair defects disrupt the structure and function of human skin
- Autophagy in Aging and Longevity Exemplified by the Aging Heart
- LRP5 promotes cancer Stem cell traits and chemoresistance in colorectal cancer
- Persistent JunB activation in fibroblasts disrupts Stem cell niche interactions enforcing skin aging
- Novel pharmacotherapy: NNI-362, an allosteric p70S6 kinase stimulator, reverses cognitive and neural regenerative deficits in models of aging and disease
- Inflammation Regulates Haematopoietic Stem Cells and Their Niche
- The Ageing Brain: Molecular and Cellular Basis of Neurodegeneration
- Development and clinical advancement of small molecules for ex vivo expansion of hematopoietic Stem cell
- Coloniality, clonality, and modularity in animals: The elephant in the room
- Adipose‐derived Stem cells regulate metabolic homeostasis and delay aging by promoting mitophagy
- Loss of TET2 Tips the Scales Toward Tumorigenesis
- An integrated network analysis approach to identify potential key genes, transcription factors, and microRNAs regulating human hematopoietic Stem cell aging
- Nanomaterials and aging
- Evolutionary perspectives on cancer and aging
- Strategies for late phase preclinical and early clinical trials of senolytics
- Iron overload-induced oxidative stress in myelodysplastic syndromes and its cellular sequelae
- Non-canonical functions of the ARF tumor suppressor in development and tumorigenesis
- The caloric restriction fallacy, rodent diet aids and the tumor suppression theory of aging
- A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of lifestyle diseases
- Formation and integration of new neurons in the adult hippocampus
- Microbial sensing by hematopoietic Stem and progenitor cells
- Organoids: An Emerging Tool to Study Aging Signature across Human Tissues. Modeling Aging with Patient-Derived Organoids
- Understanding the hedgehog signaling pathway in acute myeloid leukemia Stem cells: A necessary step toward a cure
- From development toward therapeutics, a collaborative effort on blood progenitors
- Hallmarks of T cell aging
- Regulation of cell polarity and tissue architecture in epidermal aging and cancer
- Hallmarks of aging in macrophages: Consequences to skin inflammaging
- Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a syStematic review
- Stem cell therapies for progressive multiple sclerosis
- What Is Caloric Restriction?
- The elevated level of IL-1α in the bone marrow of aged mice leads to MSC senescence partly by down-regulating Bmi-1
- Stem Cells and Aging
- Marrow failure and aging: the role of “Inflammaging”
- Differential regulation of-catenin-mediated transcription via N-and C-terminal co-factors governs identity of murine intestinal epithelial Stem cells
- Hematopoietic Stem cell Integrity Is Dependent on Znf143 Maintenance of Chromosome Structure
- Telomeres: history, health, and hallmarks of aging
- H syndrome: A review of treatment options and a hypothesis of phenotypic variability
- Myc determines the functional age state of oligodendrocyte progenitor cells
- Scinderin promotes fusion of electron transport chain dysfunctional muscle Stem cells with myofibers
- Cognitive dysfunction prevalence and associated factors in older breast cancer survivors
- Longevity leap: Mind the healthspan gap
- The effect of cultivation passaging on the relative telomere length and proliferation capacity of dental pulp Stem cells
- Previews
- Identifying biomarkers for biological age: geroscience and the ICFSR task force
- Phenotypic heterogeneity in individuals with MECOM variants in 2 families
- Excessive fetal growth affects HSC quiescence maintenance through epigenetic programming of EGR1 transcriptional network
- Donate Cryptocurrency Join the Lifespan Heroes Today! Longevity Events Ending Age-Related Diseases 2022
- Dlk1 dosage regulates hippocampal neurogenesis and cognition
- Regenerative Medicine and the Hope for a Cure
- DNA damage response priming by CK2: a matter of life or cell death in root apical meriStems
- Licochalcone A activation of glycolysis pathway has an anti-aging effect on human adipose Stem cells
- Inauguration of a unique journal Ageing and Neurodegenerative Diseases: A new beginning seeking cures for age-related neurodegenerative diseases
- MDM4: A Novel Molecular Target for Treating Idiopathic Pulmonary Fibrosis Associated with Aging
- Metabolic Analysis of Mouse Hematopoietic Stem and Progenitor Cells
- Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal Stem cells
- Continuous NF-κB pathway inhibition promotes expansion of human phenotypical hematopoietic Stem/progenitor cells through metabolism regulation
- Human Aging: From Cellular Mechanisms to Therapeutic Strategies
- Aging of hematopoietic Stem cells: Insight into mechanisms and consequences
- Aging and Cancer
- Increased LGR6 Expression Sustains Long-Term Wnt Activation and Acquisition of Senescence in Epithelial Progenitors in Chronic Lung Diseases
- Loss of dystrophin expression in skeletal muscle is associated with senescence of macrophages and endothelial cells
- The hematopoietic Stem/progenitor cell response to hemorrhage, injury, and sepsis: a review of pathophysiology
- Aging-associated immune syStem changes in multiple myeloma: The dark side of the moon.
- Transcriptomic and epigenomic profiling of young and aged spermatogonial Stem cells reveals molecular targets regulating differentiation
- Gender and Age Differences in the Hepatic Consequences of “Humanized” Bile Acid Compositions in Mice
- Partial Ablation of Non-Myogenic Progenitor Cells as a Therapeutic Approach to Duchenne Muscular Dystrophy
- GeromiRs Are Downregulated in the Tumor Microenvironment during Colon Cancer Colonization of the Liver in a Murine Metastasis Model
- CXXC5 variant in an immunodeficient patient with a progressive loss of hematopoietic cells
- Investigation of the role of inflammation in myeloproliferative neoplasms
- Modeling Neuroregeneration and Neurorepair in an Aging Context: The Power of a Teleost Model
- Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal Stem cells
- A new era for research into aging
- Epigenetic control of muscle Stem cells: time for a new dimension
- Who gets a license: DNA synthesis in quiescent cells re-entering the cell cycle
- Aging, Bone Marrow and Next-Generation Sequencing (NGS): Recent Advances and Future Perspectives
- Muscle Stem cell Fate is Directed by the Mitochondrial Fusion Protein OPA1
- The mitochondrial-derived peptide MOTS-c promotes homeostasis in aged human placenta-derived mesenchymal Stem cells in vitro
- Primary Ovarian Failure in Addition to Classical Clinical Features of Coats Plus Syndrome in a Female Carrying 2 Truncating Variants of CTC1
- Epigenetic modifications in muscle regeneration and progression of Duchenne muscular dystrophy
- Epigenetic Clocks–What are they?
- The gut microbiome, metformin, and aging
- Implications of hematopoietic Stem cells heterogeneity for gene therapies
- Biological mechanisms of aging predict age-related disease multimorbidities in patients
- CDKN1C‐mediated growth inhibition by an EZH1/2 dual inhibitor overcomes resistance of mantle cell lymphoma to ibrutinib
- Epigenetic induction of mitochondrial fission is required for maintenance of liver cancer–initiating cells
- Reviewing Cold Therapy for Longevity
- Aging Atlas: a multi-omics database for aging biology
- Nutritional Mediators of Cellular Decline and Mitochondrial Dysfunction in Older Adults
- Healing after COVID-19: are survivors at risk for pulmonary fibrosis?
- Disease-associated metabolic alterations that impact satellite cells and muscle regeneration: perspectives and therapeutic outlook
- The killifish visual syStem as an in vivo model to study brain aging and rejuvenation
- Effects of cardiotoxins on cardiac Stem and progenitor cell populations
- Genomic instability as a main driving factor of unsuccessful ageing: potential for translating the use of micronuclei into clinical practice
- RNF43: A Biomarker With Potential Ramifications for Therapeutic Intervention in Gastric Cancer
- Protein arginine methyltransferase 5: a potential cancer therapeutic target
- PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS‐STING‐Mediated Interferon Response
- Hallmarks of aging and immunosenescence: Connecting the dots
- Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
- Disease modifying agents of myeloproliferative neoplasms: a review
- Regulation of the wound healing response during aging
- Aging through an epitranscriptomic lens
- Cellular senescence in lymphoid organs and immunosenescence
- Analysis of Putative Skeletal Stem Cells Via Single cell RNA Sequencing
- JWA deficiency accelerates aging through disrupting intestinal epithelial homeostasis via Notch1/PPARγ/Stat5 axis
- Senolytic drugs: reducing senescent cell viability to extend health span
- Human primary airway basal cells display a continuum of molecular phases from health to disease in chronic obstructive pulmonary disease
- Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial Stem cells
- Impaired bone marrow microenvironment and Stem cells in transfusion-dependent beta-thalassemia
- Functional heterogeneity of mesenchymal Stem cells from natural niches to culture conditions: implications for further clinical uses
- Mouse Models of Muscle Fibrosis
- Identification of Potential Diagnostic Gene Targets for Pediatric Sepsis Based on Bioinformatics and Machine Learning
- Enhanced self-renewal of human long-term hematopoietic Stem cells by a sulfamoyl benzoate derivative targeting p18INK4C
- The Challenge of Unlocking the Biological Secrets of Aging
- Transcriptome and lipidome profile of human mesenchymal Stem cells with reduced senescence and increased trilineage differentiation ability upon drug …
- Role of cell competition in ageing
- Interferon b drives intestinal regeneration after radiation
- Roles of extracellular vesicles in the aging microenvironment and age‐related diseases
- Pasteurized non-fermented cow’s milk but not fermented milk is a promoter of mTORC1-driven aging and increased mortality
- New Perspectives of Interferon-alpha2 and Inflammation in Treating Philadelphia-negative Chronic Myeloproliferative Neoplasms
- Hypoxia-inducible factor-1α–mediated upregulation of CD99 promotes the proliferation of placental mesenchymal Stem cells by regulating ERK1/2
- Mechanisms of aging in bipolar disorder
- Cystic fibrosis lung disease in the aging population
- The Mediator captures CDK7, an attractive transcriptional target in cancer
- Beyond the storm—subacute toxicities and late effects in children receiving CAR T cells
- Ginsenoside Rg1 as a Potential Regulator of Hematopoietic Stem/Progenitor Cells
- Rejuvenation through iPSCs and reprogramming in vivo and in vitro
- Alternative stromal cell -based therapies for aging and regeneration
- Cancer Stem cells as a source of drug resistance in bone sarcomas
- Early detection of accelerated aging and cellular decline (AACD): A consensus statement
- Bioprinting of Human Cord Blood-Derived CD34+ Cells and Exploration of the Multilineage Differentiation Ability in Vitro
- Reduced CXCR4-expression on CD34-positive blood cells predicts outcomes of persons with primary myelofibrosis
- The triad inflammation-microenvironment-tumor initiating cells in leukemia progression
- Single nuclei profiling identifies cell specific markers of skeletal muscle aging, sarcopenia and senescence
- Cellular senescence links mitochondria-ER contacts and aging
- Breathe it in–Spotlight on senescence and regeneration in the lung
- The promising role of autologous and allogeneic mesenchymal stromal cells in managing knee osteoarthritis. What is beyond Mesenchymal stromal cells?
- Repetitive spikes of glucose and lipid induce senescence-like phenotypes of bone marrow Stem cells through H3K27me3 demethylase-mediated epigenetic …
- More Than Skin Deep–the Effects of Ultraviolet Radiation on Cathepsin K and Progerin Expression in Cultured Dermal Fibroblasts
- Obesity, A Condition That Mimics Premature Aging
- Senotherapeutic Drugs: A New Avenue for Skincare?
- The killifish visual syStem as an in vivo model to study brain aging and rejuvenation
- Metformin-induced microRNA-34a-3p downregulation alleviates senescence in human dental pulp Stem cells by targeting CAB39 through the AMPK/mTOR …
- Dopamine signaling regulates hematopoietic Stem and progenitor cell function
- A cellular analysis of meriStem activity at the end of flowering points to cytokinin as a major regulator of proliferative arrest in Arabidopsis
- Dance as physical exercise for older people
- Putative homeostatic role of cancer driver mutations
- From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing
- Molecular SyStems Architecture of Interactome in the Acute Myeloid Leukemia Microenvironment
- How the AHR became important in cancer: The role of chronically active AHR in cancer aggression
- The INSPIRE research initiative: A program for geroscience and healthy aging research going from animal models to humans and the healthcare syStem
- A new era for research into aging
- Age‐related changes in the energy of human mesenchymal Stem cells
- Hutchinson-Gilford progeria syndrome: rejuvenating old drugs to fight accelerated ageing
- Nanocosmeceuticals for the management of ageing: Rigors and Vigors
- RUNX3 overexpression inhibits normal human erythroid development
- Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications
- Uremic toxins and frailty in patients with chronic kidney disease: A molecular insight
- Immune syStem aging and the aging-related diseases in the COVID-19 era
- Higher Levels of Circulating Osteoprogenitor Cells Are Associated With Higher Bone Mineral Density and Lean Mass in Older Adults: A Cross‐Sectional Study
- Disease pathology in fibrotic interstitial lung disease: is it all about usual interstitial pneumonia?
- Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators
- Hereditary Hemochromatosis Associated With Idiopathic Refractory Aplastic Anemia in a Five-Year-Old Boy: A Case Report
- Anti-aging: senolytics or gerostatics (unconventional view)
- Reprogramming: Emerging Strategies to Rejuvenate Aging Cells and Tissues
- The role of mTOR in age-related diseases
- Function of telomere in aging and age related diseases
- Targeting DNMT1 by demethylating agent OR-2100 increases tyrosine kinase inhibitors-sensitivity and depletes leukemic Stem cells in chronic myeloid …
- High Temperature Inhibits The Differentiation of Spermatogonial Stem Cells
- Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution
- Ways to become old: Role of lifestyle in modulation of the hallmarks of aging
- Insufficiency of FZR1 disturbs HSC quiescence by inhibiting ubiquitin-dependent degradation of RUNX1 in aplastic anemia
- cell -centric hypotheses of aging
- Association Between Chronologic Age and Geriatric Assessment–Identified Impairments: Findings From the CARE Registry
- Taking the road less traveled–the therapeutic potential of CBP/β-catenin antagonists
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- IDH1 gene mutation activates Smad signaling molecules to regulate the expression levels of cell cycle and biological rhythm genes in human glioma U87‑MG …
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- Extracellular vesicles as novel diagnostic and prognostic biomarkers for Parkinson’s disease
- The poorly conducted orchestra of steroid hormones, oxidative stress and inflammation in frailty needs a maestro: Regular physical exercise
- Endothelial dysfunction in COPD: a syStematic review and meta-analysis of studies using different functional assessment methods
- Cellular senescence—an aging hallmark in chronic obstructive pulmonary disease pathogenesis
- Why brain functions may deteriorate with aging: a thermodynamic evaluation
- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life
- circEVI5 acts as a miR-4793-3p sponge to suppress the proliferation of gastric cancer
- Revista de Investigación Clínica-Clinical and Translational Investigation-: Editors’ Choices 6 Years Later
- Telomere maintenance and genome stability
- MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm
- The plasticity of ageing and the rediscovery of ground-state prevention
- Oxidative stress, antioxidants, hormesis and calorie restriction: The current perspective in the biology of aging
- Sex differences in biological aging with a focus on human studies
- The impact of the diet in adult C57BI/6J mice pancreas function with age
- Supplemental Material and Methods
- The Intrinsically Disordered Region in the Human STN1 OB-Fold Domain Is Important for Protecting Genome Stability
- Developing and pilot testing a frailty-focused education and communication training workshop
- 8 Identifying Life-History Events in Dental Cementum: A Literature
- Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation …
- p62 works as a hub modulation in the ageing process
- Machine learning-based predictions of dietary restriction associations across ageing-related genes
- MicroRNAs as Factors in Bidirectional Crosstalk Between Mitochondria and the Nucleus During Cellular Senescence
- Aging Justice: Health Justice Extended
- Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres
- Redox Dynamic Homeostasis and Aging
- Understanding the Potential Role of Sirtuin 2 on Aging: Consequences of SIRT2. 3 Overexpression in Senescence
- Rapid changes of miRNAs-20,-30,− 410,− 515,− 134, and− 183 and telomerase with psychological activity: A one year study on the relaxation response and …
- ADAM10 as a biomarker for Alzheimer’s disease
- Alternative animal models of aging research
- The biological relevance of pigment epithelium-derived factor on the path from aging to age-related disease
- Yeast as a model organism for aging research
- Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation
- A critical review of the mechanisms involved in the occurrence of growth-related abnormalities affecting broiler chicken breast muscles
- Transcription-Replication Collisions—A Series of Unfortunate Events
- Tenascin-C: Friend or Foe in Lung Aging?
- Single cell transcriptomic mapping of cell state identities in lung aging, injury and repair
- Characterization of Stress Responses in a Drosophila Model of Werner Syndrome
- Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls
- The ABCA1-efferocytosis axis: a new strategy to protect against atherosclerosis
- Identification of Genetic Signature Associated With Aging in Pulmonary Fibrosis
- Longitudinal Follow-Up of Blood Telomere Length in HIV-Exposed Uninfected Children Having Received One Year of Lopinavir/Ritonavir or Lamivudine as …
- Dysbiosis, malnutrition and enhanced gut-lung axis contribute to age-related respiratory diseases
- The interplay between mitochondrial morphology and myomitokines in aging sarcopenia
- The Incidence and Predictors of Solid-and Hematological Malignancies in Patients with Giant cell Arteritis: A Large Real-World Database Study
- Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome
- Ninjin’yoeito modulates feeding and activity under negative energy balance conditions via the NPY syStem
- REST/NRSF deficiency impairs autophagy and leads to cellular senescence in neurons
- Transposable elements as new players in neurodegenerative diseases
- The pro-fibrotic and senescence phenotype of old lung fibroblasts is reversed or ameliorated by genetic and pharmacological manipulation of Slc7a11 expression
- Decoding and rejuvenating human ageing genomes: Lessons from mosaic chromosomal alterations
- Non-coding RNA basis of muscle atrophy
- Lifetime impact of cow’s milk on overactivation of mTORC1: From fetal to childhood overgrowth, acne, diabetes, cancers, and neurodegeneration
- Pyroptosis, and its Role in Central Nervous SyStem Disease
- Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease
- Cardiac senescence is alleviated by the natural flavone acacetin via enhancing mitophagy
- Autophagy in Aging and Oxidative Stress
- Prodromal Parkinson disease subtypes—key to understanding heterogeneity
- Hematological consequences of malaria infection in mic e previously treated for visceral leishmaniasis [version 1; peer
- Mitochondria and Antibiotics: For Good or for Evil?
- Novel Natural Inhibitors Targeting Enhancer of Zeste Homolog 2: A Comprehensive Structural Biology Research
- Long‐Lived Cells and Long‐Lived Proteins in the Human Body
- Hematological consequences of malaria in mice previously treated for visceral leishmaniasis [version 2; peer review: 2 approved]
- Obesity definition, diagnosis, bias, standard operating procedures (SOPs), and telehealth: An Obesity Medicine Association (OMA) Clinical Practice Statement …
- Longevity pathways are associated with human ovarian ageing
- Exploration of molecular mechanism of the retina aging
- Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in Caenorhabditis elegans
- CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium
- G. sinense and P. notoginseng Extracts Improve Healthspan of Aging Flies and Provide Protection in A Huntington Disease Model
- The role of rice SOG1 and SOG1-like in DNA damage response
- Translational research in the fastest-growing population: older adults
- Targeting inflammation by anthocyanins as the novel therapeutic potential for chronic diseases: An update
- MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients’ Cells
- Mitochondria and Antibiotics: For Good or for Evil?
- The Reactive Species Interactome in the Brain
- Metabolomic Profiles of Mouse Tissues Reveal an Interplay between Aging and Energy Metabolism
- Chemical modulation of gasdermin-mediated pyroptosis and therapeutic potential
- Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function
- Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis
- Priming with growth regulators stimulates germination, growth and physiological characteristics of Indian squash (Praecitrullus fistulosus)
- Biomarkers shared by frailty and sarcopenia in older adults: A syStematic review and meta-analysis
- Osteoporosis and bone loss
- Case studies discussing the pathology, immunogenicity, and proposed mechanism of toxicity of an inhaled anti-tgfβ humanized fab antibody in non-human primates …
- Cellular senescence in brain aging
- Identification source and human health risk assessment of potentially toxic metal in soil samples around karst watershed of Pangkajene, Indonesia
- The Synergy of Adenosine and Ibrutinib on Platelet Aggregation in Chronic Lymphocytic Leukemia
- Study of longitudinal aging in mice: Presentation of experimental techniques
- Proteostasis and Skin Aging
- Proteomics and epidemiological models of human aging
- Bridging the gap: A geroscience primer for neuroscientists with potential collaborative applications
- Collagen biosynthesis, processing, and maturation in lung ageing
- MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway
- Effects of aging on gene expression levels of inflammatory, cytoskeletal and microglial markers in the brain using the zebrafish (Danio Rerio) model organism
- Vacuolar transporter Mnr2 safeguards organellar integrity in aged cells
- Transcriptomic analysis of mdx mouse muscles reveals a signature of early human Duchenne muscular dystrophy
- Single-cell Transcriptomics Reveals the Expression of Aging-and Senescence-Associated Genes in Distinct Cancer cell Populations
- Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA
- The Role of Ageing and Parenchymal Senescence on Macrophage Function and Fibrosis
- Neuropeptides: Roles and activities as metal chelators in neurodegenerative diseases
- Interferon-γ-producing CD4+ T cells drive monocyte activation in the bone marrow during experimental Leishmania donovani infection
- Therapeutic Ultrasound as a Treatment Modality for Physiological and Pathological Ageing Including Alzheimer’s Disease
- Proper control of R‐loop homeostasis is required for maintenance of gene expression and neuronal function during aging
- Olive oil consumption is associated with lower frailty risk: a prospective cohort study of community-dwelling older adults
- Physical performance in older adults: Association with glucose regulation and telomere length
- Manipulating the exposome to enable better ageing
- Vascular Aging in Rodent Models: Contrasting Mechanisms Driving the Female and Male Vascular Senescence
- MiR-29a Increase in Aging May Function as a Compensatory Mechanism Against Cardiac Fibrosis Through SERPINH1 Downregulation
- Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
- The Role of Immune Cells in Oxi-Inflamm-Aging
- The Roles of Arid2 and Arid1b in Normal and Malignant Hematopoiesis
- Mitochondria and Antibiotics: For Good or for Evil? Biomolecules 2021, 11, 1050
- Neutrophil Homeostasis and Emergency Granulopoiesis: The Example of SyStemic Juvenile Idiopathic Arthritis
- Reproductive suicide: similar mechanisms of aging in C. elegans and Pacific salmon
- A novel single-cell RNA-sequencing platform and its applicability connecting genotype to phenotype in ageing-disease
- Probiotics: Emerging functional ingredients for healthy aging and age-related diseases
- Cyclin-Dependent Kinases and CTD Phosphatases in cell Cycle Transcriptional Control: Conservation across Eukaryotic Kingdoms and Uniqueness to Plants
- Machine-learning-based predictions of caloric restriction associations across ageing-related genes
- The Danaid Theory of Aging.
- Mitochondrial biogenesis and mitophagy
- Association between elevated suPAR, a new biomarker of inflammation, and accelerated aging
- Neuronal and glial region dependent changes in female mice from a model of premature aging
- Mesenchymal Progenitors in the Epidural Fat and Dura Mater Participate in Tissue Homeostasis and Wound Healing
- Tumor Microenvironment
- Potential Roles of Sestrin2 in Alzheimer’s Disease: Antioxidation, Autophagy Promotion, and Beyond
- Microalgal Lipid Extracts Have Potential to Modulate the Inflammatory Response: A Critical Review
- Transcriptomic alterations in the aged brain with and without dietary and dietary-mimetic manipulations
- Elementary Laboratory Assays as Biomarkers of Ageing: Support for Treatment of COVID-19?
- Mitochondrial and metabolic dysfunction in ageing and age-related diseases
- Crosstalk between CST and RPA regulates RAD51 activity during replication stress
- Control of Expression of Key cell Cycle Enzymes Drives cell Line-Specific Functions of CDK7 in Human PDAC Cells
- Metabolomic Profiles of Mice Tissues Reveals an Interplay Between Aging and Energy Metabolism
- Polymethoxyflavones from Kaempferia parviflora ameliorate skin aging in primary human dermal fibroblasts and ex vivo human skin
- Nuclear Aurora-A kinase-induced hypoxia signaling drives dissemination and metastasis in breast cancer.
- Therapeutic Exon Skipping Through a CRISPR-Guided Cytidine Deaminase Rescues Dystrophic Cardiomyopathy in Vivo
- The Effect of Nutrition on Aging—A SyStematic Review Focusing on Aging-Related Biomarkers
- Anti-Inflammatory properties of diet: role in healthy aging
- The Effect of Long-Duration Spaceflight on DNA Methylation of Longevity-Related Genes in a One-Year Astronaut Study
- Precocious hippocampal structural and functional changes in gestational protein-restricted male elderly offspring: an Alzheimer-simile disease model?
- Serum Antibodies to N-Glycolylneuraminic Acid Are Elevated in Duchenne Muscular Dystrophy and Correlate with Increased Disease Pathology in Cmah−/− mdx …
- Shaping the Face. Cytoprotective mechanisms, signaling pathways and cleft repair
- Adverse effects of metformin from diabetes to COVID-19, cancer, neurodegenerative diseases, and aging: is VDAC1 a common target?
- Low Psychological Resilience in Older Individuals: An Association with Increased Inflammation, Oxidative Stress and the Presence of Chronic Medical Conditions
- Defy Aging: A Beginner’s Guide to the New Science of Longer Life and Better Health
- Nuclear receptors in myocardial and cerebral ischemia—mechanisms of action and therapeutic strategies
- Edible Beauty: Dermatologist’s Guide to an Anti-Ageing Diet
- Severe Gestational Low-Protein Intake Impacts Hippocampal Cellularity, Tau, and Amyloid-β Levels, and Memory Performance in Male Adult Offspring: An …
- Aging, cell Senescence, the Pathogenesis and Targeted Therapies of Osteoarthritis
- The prognostic value of serum metabolites
- Hallmarks of Testicular Aging: The Challenge of Anti-Inflammatory and Antioxidant Therapies Using Natural and/or Pharmacological Compounds to Improve the …
- Assessing the Use of the sGC Stimulator BAY-747, as a Potential Treatment for Duchenne Muscular Dystrophy
- Utilizing an Animal Model to Identify Brain Neurodegeneration-Related Biomarkers in Aging
- Metabolomic profiling of plasma from middle-aged and advanced-age male mice reveals the metabolic abnormalities of carnitine biosynthesis in …
- Silica Particle-Induced NLRP3 Inflammasome Activation and Dna Damage in Respiratory Epithelium
- Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies
- Ageing, comorbidities and frailty in intensive care
- Metabolomic Changes Are Predictive of Aging in Laying Hens
- Telomere replication: solving multiple end replication problems
- NAFLD in the Elderly
- Mitochondrial Physiology and Vegetal Molecules: Therapeutic Potential of Natural Compounds on Mitochondrial Health
- Effects of anti-aging interventions on intestinal microbiota
- Memorable Food: Fighting Age-Related Neurodegeneration by Precision Nutrition
- In silico identification of genetic and pharmacological interventions to modulate ageing
- Cross-sectional and longitudinal associations between adherence to Mediterranean diet with physical performance and cognitive function in older adults: a syStematic …
- Characterizing Galectin and Lysosomal Rupture’s Role in Spreading Parkinson Disease Pathology
- Longevity risk and capital markets: The 2019-20 update
- Comparative study of protein aggregation propensity and mutation tolerance between naked mole-rat and mouse
- Lifetime Impact of Cow’s Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne
- Molecular and Cellular Manifestations of Biological Aging of Cochlear Inner and Outer Hair Cells
- Toward Precision Medicine: Effects of the Common VAL66met BDNF Variant in the Aging Brain and Implications for the Future of Parkinson’S Disease …
- Fundamentals of Membrane Lipid Replacement: A Natural Medicine Approach to Repairing Cellular Membranes and Reducing Fatigue, Pain, and Other Symptoms …
- Glycosylation biomarkers associated with age-related diseases and current methods for glycan analysis
- Mitochondrial dysfunction as a driver of cellular senescence
- Analysis of the Impact of Selected Vitamins Deficiencies on the Risk of Disability in Older People
- Glycosylation and Aging
- Influence of age on skeletal muscle hypertrophy and atrophy signaling: established paradigms and unexpected links
- Understanding the Structure of Native Apolipoprotein-D Using an Integrative Structural Approach
- On chaperone co-operation in temporal and spatial protein quality control
- Inter-tissue convergence of gene expression and loss of cellular identity during ageing
- Mediators of the cellular response to the development of obesity and metabolic disease
- Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging—A Review of Literature, Clinical Data and Patents
- The African turquoise killifish (Nothobranchius furzeri): biology and research applications
- Biological Ages: Correlations, Genetic Determinants, and Health Outcomes
- Mechanisms of host defense to influenza virus infection
- The influence of sirtuin-controlled circadian rhythmicity anddiet on lifespan in the honey bee, Apis mellifera
- Sex-specific regulation of metabolic health and vertebrate lifespan by AMP biosynthesis
- The Science and Technology of Growing Young: An Insider’s Guide to the Breakthroughs that Will Dramatically Extend Our Lifespan… and What You Can Do …
- Links between abnormal lipid metabolism and inflammation in Alzheimer’s disease
- Sex Differences in Molecular Mechanisms of Cardiovascular Aging
- microRNA: target interactions in tendinopathy
- Genomic Instability at Single cell Resolution
- Epigenetics of muscle disorders
- Manipulating age-related metabolic flexibility
- Immunotherapies Targeting the Amyotrophic Lateral Sclerosis-Associated Protein TDP-43
- Body composition in 65+ European population: a focus on inflammatory and metabolic markers in healthy and frail
- p21-Activated kinase 1 (PAK1) in aging and longevity: An overview
- The Role of Yeast Shelterin Protein Cdc13 in the Stability of GAA Repeats
- A Computational Analysis in a Cohort of Parkinson’s Disease Patients and Clock-Modified Colorectal Cancer Cells Reveals Common Expression Alterations in Clock …
- Vitamin D3 Promotes Longevity in Caenorhabditis Elegans
- Elucidating the role of histone variant H2A. J following ionizing radiation
- Microglia in neuroinflammation and neurodegeneration: from understanding to therapy
- ISEV Abstract Book
- Ageing through Reproductive Death in Caenorhabditis elegans
- Histopathological features in idiopathic pulmonary fibrosis: Interobserver variation, inorganic particulate matter and prognostic factors detected by artificial intelligence
- Calorie restriction affects human nucleotide excision repair and the expression of aging-associated genes
- Synaptic Senescence in Alzheimer’s Disease
- Isolation and characterization of distinct populations of amyloid β aggregates using size exclusion chromatography and structure-specific antibody
- Effect of Oxidative Stress on Lifespan and Cellular Survival
- Protein aggregation, ageing and neurodegeneration in the emerging model Nothobranchius furzeri
- Linking mitochondrial Src and hippocampal dendritic changes in Alzheimer’s disease
- Myeloma escape after Stem cell transplantation is a consequence of T-cell exhaustion and is prevented by TIGIT blockade
- Loss of Gata4 in Sertoli cells impairs the spermatogonial Stem cell niche and causes germ cell exhaustion by attenuating chemokine signaling
- T cell exhaustion characterized by compromised MHC class I and II restricted cytotoxic activity associates with acute B lymphoblastic leukemia relapse after allogeneic …
- Autocrine Mfge8 signaling prevents developmental exhaustion of the adult neural Stem cell pool
- Bone marrow central memory and memory Stem T-cell exhaustion in AML patients relapsing after HSCT
- Correlations of programmed death 1 expression and serum IL-6 level with exhaustion of cytomegalovirus-specific T cells after allogeneic hematopoietic Stem cell …
- Therapeutic melanoma vaccine with cancer Stem cell phenotype represses exhaustion and maintains antigen-specific T cell Stemness by up-regulating BCL6
- … of growth hormone transgenic mice indicates that chronically elevated Igf1 level accelerates age-dependent exhaustion of pluripotent Stem cell pool: a novel …
- T cell exhaustion /senescence in relapsed multiple myeloma after autologous Stem cell transplantation
- … /CD200R-LSC/NK Synapse Including Leukemia Stem cell (LSC) Fraction As a Potential Therapeutic Target and Marker of NK cell exhaustion in Pediatric AML …
- exhaustion of CMV specific T cells with enhanced PD-1 expression in persistent cytomegalovirus infection after allogeneic Stem cell transplantation
- Genetic basis for haematopoietic Stem–cell exhaustion during ageing
- Haematopoietic Stem cell exhaustion in ageing killifish
- Sustained PU. 1 levels balance cell -cycle regulators to prevent exhaustion of adult hematopoietic Stem cells
- … levels of reactive oxygen species and exhaustion of the quiescent CD34+ cells may operate in poor graft function after allogeneic hematopoietic Stem cell …
- C/EBPβ is a critical regulator of CML Stem cell differentiation and exhaustion induced by interferon-α
- Correlation of serum IL-6 level with exhaustion of cytomegalovirus-specific t cells after hematopoietic Stem cell transplantation
- PF766 T cell exhaustion PROFILE (CD4+/CD28/PER+/GRA+ CD8+/CD28/PER+/GRA+) IN Stem cell TRANSPLANTATION, CMV RE ACTIVATIONS AND …
- Continuous MEK inhibition by AZD6244 (ARRY-142886) results in exhaustion of the cutaneous keratinocytic Stem cell pool and resembles senescence driven skin …
- Could Metabolic Syndrome, Lipodystrophy, and Aging Be Mesenchymal Stem cell exhaustion Syndromes?
- … COMMON DENOMINATOR: Mesenchymal Stem Cells From Idiopathic Pulmonary Fibrosis Patients Display Signs Of Senescence Leading To Stem cell exhaustion …
- T cell exhaustion /senescence characterizes multiple myeloma relapse after autologous Stem cell transplantation: Implications for optimal timing of immunotherapy
- Hematopoietic precursor cell exhaustion is a cause of proliferative defect in primitive hematopoietic Stem cells (PHSC) after chemotherapy.
- Stem cell Replicative Stress and Clonal exhaustion
- Clinical Grade Ex-Vivo Expansion of Granulomonocytic Cells and Progenitors Using High-Dose SCF and G-CSF without exhaustion of Stem cell Activity.
- THE Stem cell COMPARTMENT OF THE BONE MARROW-ATTEMPTED exhaustion BY STIMULATION OF GRANULOPOIESIS, LYMPHOPOIESIS AND …
- … of programmed death 1 expression and serum IL-6 level with exhaustion of cytomegalovirus-specific T cells after allogeneic hematopoietic Stem cell …
- Loss of the cell Cycle Regulator p26INCA1 Induces exhaustion of Leukemic Stem Cells
- Chronic Mycobacterium Avium Infection Leads to cell Autonomous exhaustion of Hematopoietic Stem Cells
