ADDICTION & STRESS
March 28, 2022STRESS & THE BRAIN
March 28, 2022
- Regulation of mTORC2 signaling
- New insights into mTOR signaling: mTORC2 and beyond
- mTORC2 in the center of cancer metabolic reprogramming
- Activation of mTORC2 by association with the ribosome
- Localization of mTORC2 activity inside cells
- Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
- Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
- mTORC2 promotes tumorigenesis via lipid synthesis
- mTORC1 and mTORC2 in cancer and the tumor microenvironment
- A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation
- Regulation and metabolic functions of mTORC1 and mTORC2
- Architecture of the human mTORC2 core complex
- A positive feedback loop between Akt and mTORC2 via SIN1 phosphorylation
- Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
- Endoplasmic reticulum is a main localization site of mTORC2
- mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
- Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
- AMPK directly activates mTORC2 to promote cell survival during acute energetic stress
- Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship
- Growth factor-dependent and-independent activation of mTORC2
- Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
- Oncogenic EGFR signaling activates an mTORC2–NF-κB pathway that promotes chemotherapy resistance
- mTORC2 controls actin polymerization required for consolidation of long-term memory
- The functional proximal proteome of oncogenic Ras includes mTORC2
- Differential dependence of hypoxia-inducible factors 1α and 2α on mTORC1 and mTORC2
- Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c
- MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling
- Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin
- mTORC2 caught in a SINful Akt
- Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014
- PRICKLE1 contributes to cancer cell dissemination through its interaction with mTORC2
- Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2
- Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3, 4, 5-trisphosphate
- HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease
- mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor
- mTORC2 signaling drives the development and progression of pancreatic cancer
- Towards specific inhibition of mTORC2
- Discrete signaling mechanisms of mTORC1 and mTORC2: Connected yet apart in cellular and molecular aspects
- Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation
- … nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and …
- The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia
- mTORC2 is required for proliferation and survival of TSC2-null cells
- PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12
- The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
- A critical role for the mTORC2 pathway in lung fibrosis
- XPLN is an endogenous inhibitor of mTORC2
- Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2
- mTORC1 and mTORC2 kinase signaling and glucose metabolism drive follicular helper T cell differentiation
- Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency
- Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
- mTORC1‐and mTORC2‐interacting proteins keep their multifunctional partners focused
- mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif
- mTORC2 regulates cardiac response to stress by inhibiting MST1
- Disruption of the scaffolding function of mLST8 selectively inhibits mTORC2 assembly and function and suppresses mTORC2-dependent tumor growth in vivo
- Inhibition of Rb phosphorylation leads to mTORC2-mediated activation of Akt
- mTORC2 signaling promotes skeletal growth and bone formation in mice
- mTORC2 regulates neutrophil chemotaxis in a cAMP-and RhoA-dependent fashion
- Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway
- In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function
- Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo
- Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex
- mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways
- Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression
- Hypothalamic mTORC2 is essential for metabolic health and longevity
- Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2
- Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα, but not S6K1
- Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer
- TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
- Selective mTORC2 inhibitor therapeutically blocks breast cancer cell growth and survival
- mTORC2: The other mTOR in autophagy regulation
- Hepatic Sirt1 deficiency in mice impairs mTORC2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
- Autophagy drives fibroblast senescence through mTORC2 regulation
- mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
- Lysosomal mTORC2/PHLPP1/Akt regulate chaperone-mediated autophagy
- Unraveling the regulation of mTORC2 using logical modeling
- mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
- mTORC2 signaling: A path for pancreatic β cell’s growth and function
- Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology
- The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex
- Pharmacological inhibition of mTORC2 reduces migration and metastasis in melanoma
- The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts
- Pathogenic role of mTORC1 and mTORC2 in pulmonary hypertension
- RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity
- Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis
- mTORC2 regulates mechanically induced cytoskeletal reorganization and lineage selection in marrow‐derived mesenchymal stem cells
- Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways
- Mitochondrial perturbations couple mTORC2 to autophagy in C. elegans
- Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling
- Critical roles for mTORC2-and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells
- The mTORC2‐Akt1 cascade is crucial for c‐Myc to promote hepatocarcinogenesis in mice and humans
- mTORC1 and mTORC2 differentially promote natural killer cell development
- mTORC2 targets AGC kinases through Sin1-dependent recruitment
- Hsp70 associates with Rictor and is required for mTORC2 formation and activity
- mTORC2 mediates CXCL12-induced angiogenesis
- Brief report: the differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation
- WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation
- Rictor/mTORC2 is essential for maintaining a balance between β-cell proliferation and cell size
- Significance of filamin A in mTORC2 function in glioblastoma
- Poxviruses evade cytosolic sensing through disruption of an mTORC1-mTORC2 regulatory circuit
- mTORC2 controls cancer cell survival by modulating gluconeogenesis
- Potential role of mTORC2 as a therapeutic target in clear cell carcinoma of the ovary
- Ras, PI3K and mTORC2–three’s a crowd?
- mTORC2 critically regulates renal potassium handling
- Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
- mTORC2 is required for rit-mediated oxidative stress resistance
- ER stress inhibits mTORC2 and Akt signaling through GSK-3β–mediated phosphorylation of Rictor
- AZD2014, an inhibitor of mTORC1 and mTORC2, is highly effective in ER+ breast cancer when administered using intermittent or continuous schedules
- mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
- Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
- Lysosome positioning influences mTORC2 and AKT signaling
- Calorie-restriction-induced insulin sensitivity is mediated by adipose mTORC2 and not required for lifespan extension
- mTORC2 is a tyrosine kinase
- Rapamycin regulates Akt and ERK phosphorylation through mTORC1 and mTORC2 signaling pathways
- Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis
- Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility
- Combating herpesvirus encephalitis by potentiating a TLR3–mTORC2 axis
- Autophagy is a survival mechanism of acute myelogenous leukemia precursors during dual mTORC2/mTORC1 targeting
- mTORC2 regulates PGE2-mediated endothelial cell survival and migration
- Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors
- Rictor/mTORC2 drives progression and therapeutic resistance of HER2-amplified breast cancers
- Novel inhibitors of mTORC1 and mTORC2.
- Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses
- Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells
- In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons
- Dramatic antitumor effects of the dual mTORC1 and mTORC2 inhibitor AZD2014 in hepatocellular carcinoma
- mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
- TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of mTORC2
- Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors
- Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2
- Predominance of mTORC1 over mTORC2 in the regulation of proliferation of ovarian cancer cells: therapeutic implications
- mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition
- mTORC2 signaling selectively regulates the generation and function of tissue-resident peritoneal macrophages
- PI3K/Akt promotes feedforward mTORC2 activation through IKKα
- Targeted inhibition of rictor/mTORC2 in cancer treatment: a new era after rapamycin
- mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
- Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis
- Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: a tale of two complexes
- Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling
- Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance
- Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
- A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2
- Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway
- Membrane tension acts through PLD2 and mTORC2 to limit actin network assembly during neutrophil migration
- Autophagy fosters myofibroblast differentiation through mTORC2 activation and downstream upregulation of CTGF
- mTORC2 signaling regulates Nox4-induced podocyte depletion in diabetes
- The combination of sorafenib and everolimus abrogates mTORC1 and mTORC2 upregulation in osteosarcoma preclinical models
- mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis
- mTORC2 responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1
- A comparison of Ku0063794, a dual mTORC1 and mTORC2 inhibitor, and temsirolimus in preclinical renal cell carcinoma models
- Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
- mTORC2 and metabolic reprogramming in GBM: at the interface of genetics and environment
- mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR
- Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways
- mTORC2 assembly is regulated by USP9X-mediated deubiquitination of RICTOR
- The mTORC1/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells
- PI3K–mTORC2 but not PI3K–mTORC1 Regulates Transcription of HIF2A/EPAS1 and Vascularization in Neuroblastoma
- Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
- mTORC2 protein-mediated protein kinase B (Akt) serine 473 phosphorylation is not required for Akt1 activity in human platelets
- Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells
- DNMT3b modulates melanoma growth by controlling levels of mTORC2 component RICTOR
- A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport
- PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation
- The SIN1-PH domain connects mTORC2 to PI3K
- Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies
- Rictor/mTORC2 loss in the Myf5 lineage reprograms brown fat metabolism and protects mice against obesity and metabolic disease
- Phosphorylated Rho–GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras–GTP to regulate cell migration
- mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3
- Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation
- Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice
- Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
- Dramatic suppression of colorectal cancer cell growth by the dual mTORC1 and mTORC2 inhibitor AZD-2014
- Dual PI3K/mTOR inhibitors induce rapid overactivation of the MEK/ERK pathway in human pancreatic cancer cells through suppression of mTORC2
- A positive feedback loop between Sestrin2 and mTORC2 is required for the survival of glutamine-depleted lung cancer cells
- Inhibition of mTORC2 component RICTOR impairs tumor growth in pancreatic cancer models
- mTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT
- Yap/Taz mediates mTORC2-stimulated fibroblast activation and kidney fibrosis
- Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity
- Direct physical interaction of active Ras with mSIN1 regulates mTORC2 signaling
- mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics
- The lipid handling capacity of subcutaneous fat is programmed by mTORC2 during development
- Targeting PI3K and mTORC2 in metastatic renal cell carcinoma: new strategies for overcoming resistance to VEGFR and mTORC1 inhibitors
- Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging
- Targeted inhibition of mTORC1 and mTORC2 by active-site mTOR inhibitors has cytotoxic effects in T-cell acute lymphoblastic leukemia
- Rictor/mTORC2 pathway in oocytes regulates folliculogenesis, and its inactivation causes premature ovarian failure
- mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity
- Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function
- FKBP4 connects mTORC2 and PI3K to activate the PDK1/Akt-dependent cell proliferation signaling in breast cancer
- Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway
- Non-canonical mTORC2 signaling regulates brown adipocyte lipid catabolism through SIRT6-FoxO1
- Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling
- mTORC2 regulates hedgehog pathway activity by promoting stability to Gli2 protein and its nuclear translocation
- Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release
- AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin
- mTORC2 is the hydrophobic motif kinase for SGK1
- mTORC1 and mTORC2 expression in inner retinal neurons and glial cells
- Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling
- CYP3A5 functions as a tumor suppressor in hepatocellular carcinoma by regulating mTORC2/Akt signaling
- Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells
- Association of mSin1 with mTORC2 Ras and Akt reveals a crucial domain on mSin1 involved in Akt phosphorylation
- Repression of human papillomavirus oncogene expression under hypoxia is mediated by PI3K/mTORC2/AKT signaling
- Identification of dual mTORC1 and mTORC2 inhibitors in melanoma cells: prodigiosin vs. obatoclax
- Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals
- Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway
- M2 polarization of macrophages by Oncostatin M in hypoxic tumor microenvironment is mediated by mTORC2 and promotes tumor growth and metastasis
- Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth …
- GILZ inhibits the mTORC2/AKT pathway in BCR-ABL+ cells
- BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas
- A phase I dose‐escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC‐223 in …
- PP242 counteracts glioblastoma cell proliferation, migration, invasiveness and stemness properties by inhibiting mTORC2/AKT
- Alkaline intracellular pH (pHi) activates AMPK–mTORC2 signaling to promote cell survival during growth factor limitation
- Phosphorylation at distinct subcellular locations underlies specificity in mTORC2-mediated activation of SGK1 and Akt
- Microtopographical cues promote peripheral nerve regeneration via transient mTORC2 activation
- Rapamycin and mTORC2 inhibition synergistically reduce contraction‐stimulated muscle protein synthesis
- Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells
- Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells
- Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
- mTORC1–S6K1 inhibition or mTORC2 activation improves hippocampal synaptic plasticity and learning in Angelman syndrome mice
- PKBγ/AKT3 loss-of-function causes learning and memory deficits and deregulation of AKT/mTORC2 signaling: Relevance for schizophrenia
- DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1
- The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
- A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies
- The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis
- The underlying mechanism of proinflammatory NF-κB activation by the mTORC2/Akt/IKKα pathway during skin aging
- mTORC2 signaling is necessary for timely liver regeneration after partial hepatectomy
- Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury
- mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells
- Phosphoproteomic analysis implicates the mTORC2-FoxO1 axis in VEGF signaling and feedback activation of receptor tyrosine kinases
- mTORC2 affects the maintenance of the muscle stem cell pool
- IKK interacts with rictor and regulates mTORC2
- Role of mTORC1 and mTORC2 in breast cancer: therapeutic targeting of mTOR and its partners to overcome metastasis and drug resistance
- CD146 regulates growth factor-induced mTORC2 activity independent of the PI3K and mTORC1 pathways
- eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt/mTORC2 signaling
- DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway
- Combined mTORC1/mTORC2 inhibition blocks growth and induces catastrophic macropinocytosis in cancer cells
- Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex
- Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice [S]
- Rictor/mTORC2 regulates blood‐testis barrier dynamics via its effects on gap junction communications and actin filament network
- Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo
- Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis
- Calcium mediates glomerular filtration through calcineurin and mTORC2/Akt signaling
- mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling
- Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways
- mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells
- mTORC1 and mTORC2 differentially regulate cell fate programs to coordinate osteoblastic differentiation in mesenchymal stromal cells
- mTORC2 forms iron-clad defense to guard memory
- KU0063794, a dual mTORC1 and mTORC2 inhibitor, reduces neural tissue damage and locomotor impairment after spinal cord injury in mice
- mTORC2 confers neuroprotection and potentiates immunity during virus infection
- MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway
- mTORC2 promotes cell survival through c-Myc–dependent up-regulation of E2F1
- Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction
- Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTORC2 activation
- Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target
- mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
- mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma
- mTORC2/AKT/HSF1/HuR constitute a feed-forward loop regulating Rictor expression and tumor growth in glioblastoma
- Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition
- mTORC2/rictor signaling disrupts dopamine-dependent behaviors via defects in striatal dopamine neurotransmission
- mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism
- Activation of Rictor/mTORC2 signaling acts as a pivotal strategy to protect against sensorineural hearing loss
- mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway
- mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel
- Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2α expression and cell proliferation
- mTORC2 balances AKT activation and eIF2α serine 51 phosphorylation to promote survival under stress
- Branched‐chain amino acids prevent insulin‐induced hepatic tumor cell proliferation by inducing apoptosis through mTORC1 and mTORC2‐dependent mechanisms
- KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis
- LPS induces mTORC1 and mTORC2 activation during monocyte adhesion
- Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2
- mTORC2 modulates the amplitude and duration of GFAT1 Ser-243 phosphorylation to maintain flux through the hexosamine pathway during starvation
- Rapamycin ameliorates inflammation and fibrosis in the early phase of cirrhotic portal hypertension in rats through inhibition of mTORC1 but not mTORC2
- PARP3, a new therapeutic target to alter Rictor/mTORC2 signaling and tumor progression in BRCA1-associated cancers
- Hetero-oligomerization of Rho and Ras GTPases connects GPCR activation to mTORC2-AKT signaling
- mTORC2/Rac1 pathway predisposes cancer aggressiveness in IDH1-mutated glioma
- The mTORC2/Akt/NFκB pathway-mediated activation of TRPC6 participates in adriamycin-induced podocyte apoptosis
- BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation
- Fumonisin B1 induces nephrotoxicity via autophagy mediated by mTORC1 instead of mTORC2 in human renal tubule epithelial cells
- Inhibition of mTORC2/RICTOR impairs melanoma hepatic metastasis
- mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen sulfide-induced cardioprotection
- Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization
- Combined inhibition of mTORC1 and mTORC2 signaling pathways is a promising therapeutic option in inhibiting pheochromocytoma tumor growth: in vitro and in vivo …
- PTEN negatively regulates mTORC2 formation and signaling in grade IV glioma via Rictor hyperphosphorylation at Thr1135 and direct the mode of action of …
- CD40-induced signaling in human endothelial cells results in mTORC2-and Akt-dependent expression of vascular endothelial growth factor in vitro and in vivo
- Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism …
- Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney
- Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis
- mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma
- Morphoproteomic analysis reveals an overexpressed and constitutively activated phospholipase D1-mTORC2 pathway in endometrial carcinoma
- Loss of GCN5L1 in cardiac cells disrupts glucose metabolism and promotes cell death via reduced Akt/mTORC2 signaling
- PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils
- mTORC2 dictates Warburg effect and drug resistance
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum-and glucocorticoid-induced protein kinase 1 (SGK1)
- Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis …
- mTOR modulates resistance to gemcitabine in lung cancer in an mTORC2 dependent mechanism
- TELO2 induced progression of colorectal cancer by binding with RICTOR through mTORC2
- mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction in traumatic optic nerve injury
- mTORC2 deficiency in myeloid dendritic cells enhances their allogeneic Th1 and Th17 stimulatory ability after TLR4 ligation in vitro and in vivo
- T cells encountering myeloid cells programmed for amino acid-dependent immunosuppression use Rictor/mTORC2 protein for proliferative checkpoint …
- mTORC1 and mTORC2 play different roles in the functional survival of transplanted adipose‐derived stromal cells in hind limb ischemic mice via regulating …
- IBP-mediated suppression of autophagy promotes growth and metastasis of breast cancer cells via activating mTORC2/Akt/FOXO3a signaling pathway
- The mTORC2 component rictor contributes to cisplatin resistance in human ovarian cancer cells
- Functional impacts of the BRCA1-mTORC2 interaction in breast cancer
- Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice
- … expression of mTOR components in endometriosis and ovarian cancer: Effects of rapalogues and dual kinase inhibitors on mTORC1 and mTORC2 …
- Roles of mTORC1 and mTORC2 in controlling γδ T1 and γδ T17 differentiation and function
- Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling
- The miR-491-3p/mTORC2/FOXO1 regulatory loop modulates chemo-sensitivity in human tongue cancer
- Targeted inhibition of mTORC2 prevents osteosarcoma cell migration and promotes apoptosis
- Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination
- The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt
- Identification of MΦ specific POTEE expression: Its role in mTORC2 activation via protein-protein interaction in TAMs
- mTOR pathway in papillary thyroid carcinoma: different contributions of mTORC1 and mTORC2 complexes for tumor behavior and SLC5A5 mRNA expression
- Quantitative proteomics implicates Rictor/mTORC2 in cell adhesion
- Inhibition of mTORC2 induces cell-cycle arrest and enhances the cytotoxicity of doxorubicin by suppressing MDR1 expression in HCC cells
- The calcineurin variant CnAβ1 controls mouse embryonic stem cell differentiation by directing mTORC2 membrane localization and activation
- CUL5-SOCS6 complex regulates mTORC2 function by targeting Sin1 for degradation
- mTORC2 suppresses GSK3-dependent snail degradation to positively regulate cancer cell invasion and metastasis
- TGFβ-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (α2) gene expression
- Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors
- Identification of mTORC2 as a necessary component of HRG/ErbB2-dependent cellular transformation
- Dual mTORC1/mTORC2 inhibition as a host-directed therapeutic target in pathologically distinct mouse models of tuberculosis
- Rapamycin‐Induced Hypophosphatemia and Insulin Resistance Are Associated With mTORC2 Activation and Klotho Expression
- Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines
- Taurine improves low‐level inorganic arsenic‐induced insulin resistance by activating PPARγ‐mTORC2 signalling and inhibiting hepatic autophagy
- First-in-human phase I trial of the dual mTORC1 and mTORC2 inhibitor AZD2014 in solid tumors.
- RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma
- Functional role of mTORC2 versus integrin-linked kinase in mediating Ser473-Akt phosphorylation in PTEN-negative prostate and breast cancer cell lines
- Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1
- The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro
- Rictor/mTORC2 loss in osteoblasts impairs bone mass and strength
- The mTOR inhibitor manassantin B reveals a crucial role of mTORC2 signaling in Epstein-Barr virus reactivation
- … resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2
- Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down‐regulation of Mcl‐1 in mantle cell lymphoma
- Inhibition of the mTORC2 and chaperone pathways to treat leukemia
- Anti-CD44 antibodies inhibit both mTORC1 and mTORC2: a new rationale supporting CD44-induced AML differentiation therapy
- The GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation
- Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin
- Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial …
- Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
- Ras functional proximity proteomics establishes mTORC2 as new direct ras effector
- mTORC1 and mTORC2 coordinate early NK cell development by differentially inducing E4BP4 and T-bet
- mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells
- mTORC2-PKBα/Akt1 Serine 473 phosphorylation axis is essential for regulation of FOXP3 Stability by chemokine CCL3 in psoriasis
- Coordinate control of host centrosome position, organelle distribution, and migratory response by Toxoplasma gondii via host mTORC2
- Polystyrene microplastics disrupt the blood-testis barrier integrity through ROS-Mediated imbalance of mTORC1 and mTORC2
- Critical role of mTORC2-Akt signaling in TGF-β1-induced myofibroblast differentiation of human pterygium fibroblasts
- Selective concomitant inhibition of mTORC1 and mTORC2 activity in estrogen receptor negative breast cancer cells by BN107 and oleanolic acid
- mTORC2 is involved in the induction of RSK phosphorylation by serum or nutrient starvation
- Therapeutic Targeting of mTORC2 in mTORopathies
- TLR4 counteracts BVRA signaling in human leukocytes via differential regulation of AMPK, mTORC1 and mTORC2
- Targeting of mTORC2 may have advantages over selective targeting of mTORC1 in the treatment of malignant pheochromocytoma
- Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway
- Active mTORC2 signaling in naive T cells suppresses bone marrow homing by inhibiting CXCR4 expression
- Reduced menin expression impairs rapamycin effects as evidenced by an increase in mTORC2 signaling and cell migration
- Upregulation of mTORC2 activation by the selective agonist of EPAC, 8‐CPT‐2Me‐cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex
- mTORC2 negatively controls the maturation process of medullary thymic epithelial cells by inhibiting the LTβR/RANK‐NF‐κB axis
- Leucine facilitates the insulin-stimulated glucose uptake and insulin signaling in skeletal muscle cells: involving mTORC1 and mTORC2
- mTORC2 deploys the mRNA binding protein IGF2BP1 to regulate c-MYC expression and promote cell survival
- Cross-talks via mTORC2 can explain enhanced activation in response to insulin in diabetic patients
- Metallothionein Protects the Heart Against Myocardial Infarction via the mTORC2/FoxO3a/Bim Pathway
- Induction of autophagy by dual mTORC1-mTORC2 inhibition in BCR-ABL-expressing leukemic cells
- Dual mTORC1 and mTORC2 inhibitor Palomid 529 penetrates the blood–brain barrier without restriction by ABCB1 and ABCG2
- Amplifying mTORC2 signals through AMPK during energetic stress
- … inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical …
- Insulin-dependent regulation of mTORC2-Akt-FoxO suppresses TLR4 signaling in human leukocytes: relevance to type 2 diabetes
- Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43
- Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction
- … between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2
- Disentangling the signaling pathways of mTOR complexes, mTORC1 and mTORC2, as a therapeutic target in glioblastoma
- Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling
- mTORC2 (Rictor) in Alzheimer’s disease and reversal of amyloid-β expression-induced insulin resistance and toxicity in rat primary cortical neurons
- mTORC2 regulates multiple aspects of NKT‐cell development and function
- Integrity of mTORC2 is dependent on the rictor Gly-934 site
- Receptor-Recognized α2-Macroglobulin Binds to Cell Surface-Associated GRP78 and Activates mTORC1 and mTORC2 Signaling in Prostate Cancer Cells
- Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo
- Regulation of insulin receptor substrate-1 by mTORC2 (mammalian target of rapamycin complex 2)
- Hepatic FOXO1 target genes are co-regulated by thyroid hormone via RICTOR protein deacetylation and mTORC2-AKT protein inhibition
- mTORC2 activity disrupts lysosome acidification in systemic lupus erythematosus by impairing caspase-1 cleavage of Rab39a
- mTORC2 regulates hierarchical micro/nano topography‐induced osteogenic differentiation via promoting cell adhesion and cytoskeletal polymerization
- Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation
- Targeting mTORC2 component rictor inhibits cell proliferation and promotes apoptosis in gastric cancer
- Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc
- Endoplasmic reticulum-localized ECM1b suppresses tumor growth and regulates MYC and MTORC1 through modulating mTORC2 activation in esophageal …
- Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and …
- Opposing tumor-promoting and-suppressive functions of rictor/mTORC2 signaling in adult glioma and pediatric SHH medulloblastoma
- AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B-cell receptor-mediated survival
- The Bardet–Biedl syndrome-related protein CCDC28B modulates mTORC2 function and interacts with SIN1 to control cilia length independently of the mTOR complex
- Exercise increases phosphorylation of the putative mTORC2 activity readout NDRG1 in human skeletal muscle
- Metabolic regulation of T cell development by Sin1–mTORC2 is mediated by pyruvate kinase M2
- mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption
- Uropathogenic Escherichia coli infection compromises the blood-testis barrier by disturbing mTORC1-mTORC2 balance
- Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
- TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling
- Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages
- mTORC2 in thymic epithelial cells controls thymopoiesis and T cell development
- PtdIns (3, 4, 5) P3-dependent activation of the mTORC2 kinase complex
- Wnt5a regulates junctional function of Sertoli cells through PCP-mediated effects on mTORC1 and mTORC2
- Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle …
- A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin
- Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling
- Calpain‐activated mTORC2/Akt pathway mediates airway smooth muscle remodelling in asthma
- Rapamycin inhibits ox-LDL-induced inflammation in human endothelial cells in vitro by inhibiting the mTORC2/PKC/c-Fos pathway
- Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3β signaling
- Resveratrol activates natural killer cells through Akt-and mTORC2-Mediated c-Myb upregulation
- Proliferating helper T cells require Rictor/mTORC2 complex to integrate signals from limiting environmental amino acids
- Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes
- Insulin upregulates the expression of epithelial sodium channel in vitro and in a mouse model of acute lung injury: role of mTORC2/SGK1 pathway
- Inflammation-induced mTORC2-Akt-mTORC1 signaling promotes macrophage foam cell formation
- Rictor-targeting exosomal microRNA-16 ameliorates lung fibrosis by inhibiting the mTORC2-SPARC axis
- Dual targeting of mTORC1 and mTORC2 by INK-128 potently inhibits human prostate cancer cell growth in vitro and in vivo
- BCKA down-regulates mTORC2-Akt signal and enhances apoptosis susceptibility in cardiomyocytes
- Dual inhibition of mTORC1 and mTORC2 perturbs cytoskeletal organization and impairs endothelial cell elongation
- mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma
- mTORC2, the “other” mTOR, is a new player in energy balance regulation
- NGF signaling in PC12 cells: the cooperation of p75NTR with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade
- Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways
- Transmembrane inhibitor of RICTOR/mTORC2 in hematopoietic progenitors
- mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling
- Therapeutic implication of mTORC2 in oral squamous cell carcinoma
- Rapamycin inhibits both motility through down-regulation of p-STAT3 (S727) by disrupting the mTORC2 assembly and peritoneal dissemination in sarcomatoid …
- Down-regulation of Rictor enhances cell sensitivity to PI3K inhibitor LY294002 by blocking mTORC2-medicated phosphorylation of Akt/PRAS40 in …
- Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia
- Heat stress-induced PI3K/mTORC2-dependent AKT signaling is a central mediator of hepatocellular carcinoma survival to thermal ablation induced heat …
- mTORC2 Regulates lipogenic gene expression through PPARγ to control lipid synthesis in bovine mammary epithelial cells
- DDR2 induces gastric cancer cell activities via activating mTORC2 signaling and is associated with clinicopathological characteristics of gastric cancer
- Shear Stress Increases V–H + -ATPase and Acidic Vesicle Number Density, and p-mTORC2 Activation in Prostate Cancer Cells
- Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein
- mTORC2 contributes to the metabolic reprogramming in EGFR tyrosine-kinase inhibitor resistant cells in non-small cell lung cancer
- Citreoviridin induces myocardial apoptosis through PPAR-γ-mTORC2-mediated autophagic pathway and the protective effect of thiamine and selenium
- mTORC2: actin on your memory
- Endosomal mTORC2 is required for phosphoinositide-dependent AKT activation in platelet-derived growth factor-stimulated glioma cells
- DNA polymerase gamma (Polγ) deficiency triggers a selective mTORC2 prosurvival autophagy response via mitochondria-mediated ROS signaling
- Alcohol‐induced modulation of rictor and mTORC2 activity in C2C12 myoblasts
- Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2
- First results from a phase I trial of AZD8055, a dual mTORC1 and mTORC2 inhibitor.
- Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling
- Correction: Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma
- Developmentally spliced PKCβII provides a possible link between mTORC2 and Akt kinase to regulate 3T3-L1 adipocyte insulin-stimulated glucose transport
- Intratumoral delivery of mTORC2-deficient dendritic cells inhibits B16 melanoma growth by promoting CD8+ effector T cell responses
- Protective effect of docosahexaenoic acid on lipotoxicity‐mediated cell death in Schwann cells: Implication of PI3K/AKT and mTORC2 pathways
- Physical interaction of estrogen receptor with MnSOD: Implication in mitochondrial O2.− upregulation and mTORC2 potentiation in estrogen-responsive breast cancer …
- Estrogen receptor potentiates mTORC2 signaling in breast cancer cells by upregulating superoxide anions
- … regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein
- UVB-induced inactivation of manganese-containing superoxide dismutase promotes mitophagy via ROS-mediated mTORC2 pathway activation
- EBV LMP1-activated mTORC1 and mTORC2 Coordinately Promote Nasopharyngeal Cancer Stem Cell Properties
- A germline-specific role for the mTORC2 component Rictor in maintaining spermatogonial differentiation and intercellular adhesion in mouse testis
- Deconvolution of mTORC2 “in silico”
- Gremlin promotes retinal pigmentation epithelial (RPE) cell proliferation, migration and VEGF production via activating VEGFR2-Akt-mTORC2 signaling
- The mTORC2/PKC pathway sustains compensatory insulin secretion of pancreatic β cells in response to metabolic stress
- The 3.2-Å resolution structure of human mTORC2
- mTORC1 and mTORC2 converge on the Arp2/3 complex to promote KrasG12D-induced acinar-to-ductal metaplasia and early pancreatic carcinogenesis
- Caffeine inhibits PI3K and mTORC2 in Dictyostelium and differentially affects multiple other cAMP chemoattractant signaling effectors
- Loss of mTORC2‐induced metabolic reprogramming in monocytes uncouples migration and maturation from production of proinflammatory mediators
- RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes
- Combination of mTOR and EGFR kinase inhibitors blocks mTORC1 and mTORC2 kinase activity and suppresses the progression of colorectal carcinoma
- Abrogation of chronic rejection in rat model system involves modulation of the mTORC1 and mTORC2 pathways
- Inhibition of mTORC2 but not mTORC1 up-regulates E-cadherin expression and inhibits cell motility by blocking HIF-2α expression in human renal cell carcinoma
- Gonadotropin releasing hormone activation of the mTORC2/Rictor complex regulates actin remodeling and ERK activity in LβT2 cells
- Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro
- αMSH prevents ROS-induced apoptosis by inhibiting Foxo1/mTORC2 in mice adipose tissue
- Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling
- Hydrogen peroxide (H2O2) mediated activation of mTORC2 increases intracellular Na+ concentration in the renal medullary thick ascending limb of Henle
- 17ss-Estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodeling
- Heterogeneous nuclear ribonucleoprotein M associates with mTORC2 and regulates muscle differentiation
- Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast …
- Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons
- Akt and PKC are involved not only in upregulation of telomerase activity but also in cell differentiation-related function via mTORC2 in leukemia cells
- Lysosomal mTORC2/PHLPP1/Akt axis: a new point of control of chaperone-mediated autophagy
- mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis
- mTORC2/Rictor is essential for coelomocyte endocytosis in Apostichopus japonicus
- mTORC1 and mTORC2 expression levels in oral squamous cell carcinoma: an immunohistochemical and clinicopathological study
- mTORC2 puts its shoulder to krebs’ wheel
- P27 Promotes TGF-β-Mediated Pulmonary Fibrosis via Interacting with mTORC2
- A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms
- Fisetin-induced PTEN expression reverses cellular senescence by inhibiting the mTORC2-Akt Ser473 phosphorylation pathway in vascular smooth muscle cells
- AZD2014, a dual mTORC1 and mTORC2 inhibitor is differentiated from allosteric inhibitors of mTORC1 in ER+ breast cancer
- LCP1 triggers mTORC2/AKT activity and is pharmacologically targeted by enzastaurin in hypereosinophilia
- The mTORC2 Component Rictor Is Required for Load‐Induced Bone Formation in Late‐Stage Skeletal Cells
- Enhancing Acsl4 in absence of mTORC2/Rictor drove β-cell dedifferentiation via inhibiting FoxO1 and promoting ROS production
- mTORC1 and mTORC2 play different roles in regulating cardiomyocyte differentiation from embryonic stem cells
- Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle
- Bisphenol S perturbs Sertoli cell junctions in male rats via alterations in cytoskeletal organization mediated by an imbalance between mTORC1 and mTORC2
- Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W
- Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)
- mTORC2 is an important target for simvastatin-associated toxicity in C2C12 cells and mouse skeletal muscle–Roles of Rap1 geranylgeranylation and …
- Two conserved glycine residues in mammalian and Dictyostelium Rictor are required for mTORC2 activity and integrity
- Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female …
- Caffeine inhibits EGF-stimulated trophoblast cell motility through the inhibition of mTORC2 and Akt
- Avian reovirus p17 and σA act cooperatively to downregulate Akt by suppressing mTORC2 and CDK2/cyclin A2 and upregulating proteasome PSMB6
- microRNA-153 targets mTORC2 component rictor to inhibit glioma cells
- Lycopene Protects Keratinocytes Against UVB Radiation‐Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway
- Phospholipase D stabilizes HDM2 through an mTORC2/SGK1 pathway
- Phosphoinositide-dependent kinase 1 and mTORC2 synergistically maintain postnatal heart growth and heart function in mice
- T-2 toxin exposure induces apoptosis in TM3 cells by inhibiting mammalian target of rapamycin/serine/threonine protein kinase (mTORC2/AKT) to promote Ca2+ …
- Delayed tooth movement in Runx2+/− mice associated with mTORC2 in stretch-induced bone formation
- Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)
- Hydrophobic motif site-phosphorylated protein kinase CβII between mTORC2 and Akt regulates high glucose-induced mesangial cell hypertrophy
- Mammalian target of rapamycin complex 2 (mTORC2) controls glycolytic gene expression by regulating Histone H3 Lysine 56 acetylation
- MicroRNA-7-5p regulates human alveolar epithelial sodium channels by targeting the mTORC2/SGK-1 signaling pathway
- Stimulation of mTORC2 by integrin αIIbβ3 is required for PI3Kβ-dependent activation of Akt but is dispensable for platelet spreading on fibrinogen
- XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts
- ATP-site binding inhibitor effectively targets mTORC1 and mTORC2 complexes in glioblastoma
- mTORC2 deficiency alters the metabolic profile of conventional dendritic cells
- Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2
- Effective-components combination improves airway remodeling in COPD rats by suppressing M2 macrophage polarization via the inhibition of mTORC2 …
- IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant …
- Loss of mTORC2 Activity in Neutrophils Impairs Fusion of Granules and Affects Cellular Metabolism Favoring Increased Bacterial Burden in Sepsis
- Morin Acts as a USP7 Inhibitor to Hold Back the Migration of Rheumatoid Arthritis Fibroblast‐Like Synoviocytes in a “Prickle1‐mTORC2” Dependent Manner
- Sin1 promotes proliferation and invasion of prostate cancer cells by modulating mTORC2-AKT and AR signaling cascades
- The dual mTORC1 and mTORC2 inhibitor PP242 shows strong antitumor activity in a pheochromocytoma PC12 cell tumor model
- Inhibition of the IGF-1–PI3K–Akt–mTORC2 pathway in lipid rafts increases neuronal vulnerability in a genetic lysosomal glycosphingolipidosis
- Sirt1 Mediates Vitamin D Deficiency-Driven Gluconeogenesis in the Liver via mTORC2/Akt Signaling
- Fibroblast growth factor 1 ameliorates adipose tissue inflammation and systemic insulin resistance via enhancing adipocyte mTORC2/Rictor signal
- Is dual mTORC1 and mTORC2 therapeutic blockade clinically feasible in cancer?
- TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation
- Autophagy and receptor tyrosine kinase signalling: A mTORC2 matter
- mTORC2 activation is regulated by the urokinase receptor (uPAR) in bladder cancer
- Mdm20 modulates actin remodeling through the mTORC2 pathway via its effect on rictor expression
- Comment on “A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation”: building a model of the mTOR signaling network with a …
- Yin Yang 1 promotes mTORC2-mediated AKT phosphorylation
- The mammalian Target of Rapamycin (mTOR) regulates T helper cell differentiation through the selective activation of mTORC1 and mTORC2 signaling
- Mechanisms mediating the effects of alcohol and HIV anti-retroviral agents on mTORC1, mTORC2 and protein synthesis in myocytes
- GSK3 inhibitor AR-A014418 promotes osteogenic differentiation of human adipose-derived stem cells via ERK and mTORC2/Akt signaling pathway
- Diiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity
- mTORC2 Activation Mediated by Mesenchymal Stem Cell-Secreted Hepatocyte Growth Factors for the Recovery of Lipopolysaccharide-Induced Vascular …
- mTORC2 coordinates pulmonary artery smooth muscle cell metabolism, proliferation and survival in pulmonary arterial hypertension
- Calcium sensing receptor stimulates breast cancer cell migration via the Gβγ-AKT-mTORC2 signaling pathway
- Targeting mTORC2/HDAC3 Inhibits Stemness of Liver Cancer Cells Against Glutamine Starvation
- P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer
- Enhanced Akt phosphorylation and myogenic differentiation in PI3K p110β-deficient myoblasts is mediated by PI3K p110α and mTORC2
- Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis
- GPR30‐mediated estrogenic regulation of actin polymerization and spatial memory involves SRC‐1 and PI3K‐mTORC2 in the hippocampus of female mice
- Mechanistic target of rapamycin complex 1 (mTORC1) and mTORC2 as key signaling intermediates in mesenchymal cell activation
- Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS‐induced expression of IL‐12 and IL‐23 in human dendritic cells
- Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-κB pathways and expressions of IGF-1R, Sirt1, COX-2, and FASN in peripheral …
- Morphoproteomics and biomedical analytics confirm the mTORC2/Akt pathway as a resistance signature and activated ERK and STAT3 as concomitant …
- AMPK and the PI3K-mTORC2-AKT axis shape the mitochondrial integrated-stress-response
- … of blood–testis barrier (BTB) dynamics during spermatogenesis via the “Yin” and “Yang” effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2
- Dihydrocelastrol exerts potent antitumor activity in mantle cell lymphoma cells via dual inhibition of mTORC1 and mTORC2
- Role of mTORC2 in biphasic regulation of brown fat metabolism in response to mild and severe cold
- Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion
- KPT-9274, an inhibitor of PAK4 and NAMPT, leads to downregulation of mTORC2 in triple negative breast cancer cells
- Rictor/mTORC2 is involved in endometrial receptivity by regulating epithelial remodeling
- Structural features of mTORC2 that control substrate-specific activities
- mTORC2 steals the spotlight
- Omega-3 polyunsaturated fatty acids attenuate fibroblast activation and kidney fibrosis involving mTORC2 signaling suppression
- PI3K regulation of the SKP-2/p27 axis through mTORC2
- The Deubiquitinase USP39 Promotes ESCC Tumorigenesis Through Pre-mRNA Splicing of the mTORC2 Component Rictor
- TIS21/BTG2 inhibits breast cancer growth and progression by differential regulation of mTORc1 and mTORC2–AKT1–NFAT1–PHLPP2 signaling axis
- Calpain-2 activates Akt via TGF-β1-mTORC2 pathway in pulmonary artery smooth muscle cells
- Activating transcription factor 4 modulates TGFβ-induced aggressiveness in triple-negative breast cancer via SMAD2/3/4 and mTORC2 signaling
- SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt
- Prohibitin-Mediated Lifespan and Mitochondrial Stress Implicate SGK-1, Insulin/IGF and mTORC2 in C. elegans
- Depletion of Ric-8B leads to reduced mTORC2 activity
- P-OT002. Alcohol consumption alters the amygdalar protein expression of mTORC2 in male Wistar rats
- β-Barrel outer membrane proteins suppress mTORC2 activation and induce autophagic responses
- Bladder Cancer Invasion is Mediated by mTORC2-Driven Regulation of Nitric Oxide and Invadopodia Formation.
- DNMT1, a novel regulator mediating mTORC1/mTORC2 pathway-induced NGF expression in schwann Cells
- Interferon γ (IFNγ) signaling via mechanistic target of rapamycin complex 2 (mTORC2) and regulatory effects in the generation of type II interferon biological …
- mTORC2 brings up the rear
- Abstract A168: First results from a phase I trial of AZD8055, a dual mTORC1 and mTORC2 inhibitor.
- Combinatorial Inhibition of mTORC2 and Hsp90 leads to a distinctly effective therapeutic strategy in malignant Pheochromocytoma
- Bone morphogenetic protein 4 (BMP4) promotes hepatic glycogen accumulation and reduces glucose level in hepatocytes through mTORC2 signaling …
- Chronic rapamycin treatment exacerbates metabolism and does not down-regulate mTORC2/Akt signaling in diabetic mice induced by high-fat diet and streptozotocin
- … urine in the obstructed kidney promotes urothelial carcinoma cell proliferation, migration, invasion through the activation of mTORC2-AKT and ERK signaling …
- … phosphoprotein 1 cooperatively stimulate migration and adhesion of ovine trophectoderm cells via focal adhesion-mTORC2 mediated cytoskeleton reorganization
- Polycystin‐1 regulates cell proliferation and migration through AKT/mTORC2 pathway in a human craniosynostosis cell model
- Rictor amplification promotes NSCLC cell proliferation through formation and activation of mTORC2 at the expense of mTORC1
- … Expression of FK506-binding protein 12-rapamycin complex-associated protein 1 (FRAP1) and regulators and effectors of mTORC1 and mTORC2 complexes in ovine …
- Stimulatory effect of insulin on H + -ATPase in the proximal tubule via the Akt/mTORC2 pathway
- mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity
- The mTORC2 Regulator Homer1 Modulates Protein Levels and Sub-Cellular Localization of the CaSR in Osteoblast-Lineage Cells
- Halting renal fibrosis: an unexpected role for mTORC2 signaling
- Protein phosphatase 6 promotes neurite outgrowth by promoting mTORC2 activity in N2a cells
- HIV-1 Nef-POTEE; a novel interaction modulates macrophage dissemination via mTORC2 signaling pathway
- Implication of BAG5 downregulation in metabolic reprogramming of cisplatin-resistant ovarian cancer cells via mTORC2 signaling pathway
- Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but …
- … (TNF-α)-mediated in vitro human retinal pigment epithelial (RPE) cell migration mainly requires Akt/mTOR complex 1 (mTORC1), but not mTOR complex 2 (mTORC2) …
- Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1
- Selective obstruction of the mTORC2 complex by a naturally occurring cholestane saponin (OSW-1) for inhibiting prostate cancer cell growth
- mTORC2: The other facet of mTOR
- Na+ influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation
- c-Jun N-terminal kinase (JNK)–mediated induction of mSin1 expression and mTORC2 activation in mesenchymal cells during fibrosis
- Rictor overexpression and mTORC2 signaling in chronic lymphocytic leukemia
- Coinhibition of mTORC1/mTORC2 and RhoA/ROCK pathways prevents chronic rejection of rat cardiac allografts
- mTORC2 deficiency in cutaneous dendritic cells potentiates CD8+ effector T cell responses and accelerates skin graft rejection
- Architecture of the human mTORC2 core complex
- Impaired mTORC2 signaling in catecholaminergic neurons exaggerates high fat diet-induced hyperphagia
- Erratum to: Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition
- High-throughput screening for mTORC1/mTORC2 kinase inhibitors using a chemiluminescence-based ELISA assay
- When mTORC2-AKT signaling meets cell polarity
- Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue
- Role for mTORC2 in insulin resistance
- Author correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
- In B cells, phosphatidylinositol 5-phosphate 4-kinase–α synthesizes PI (4, 5) P2 to impact mTORC2 and Akt signaling
- Targeting mLST8 in mTORC2-dependent cancers
- Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication
- mTORC2 takes the longevity stAGE
- Dual mTORC1/mTORC2 blocker as a possible therapy for tauopathy in cellular model
- Torin2 overcomes sorafenib resistance via suppressing mTORC2-AKT-BAD pathway in hepatocellular carcinoma cells
- mTORC2 contributes to murine lupus
- Imidazo [1, 5-a] pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2
- The antipancreatic cancer activity of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2
- mTORC1 and mTORC2 in energy homeostasis
- Dual inhibition of mTORC1/mTORC2 induces apoptosis of mantle cell lymphoma by preventing rictor mediated AKTS473 phosphorylation by potentiating AKT2 …
- In vivo and in vitro impact of miRNA-153 on the suppression of cell growth apoptosis through mTORC2 signaling pathway in breast cancer
- Negative regulation of mTORC2 by glycogen synthase kinase-3β: an adaptive process to stress with an anticancer therapeutic potential?
- XPLN is a novel regulator of mTORC2
- Development of monoclonal antibody against protein Rictor, a component of the mTORC2 complex
- mTORC2 loss in oligodendrocyte progenitor cells results in regional hypomyelination in the central nervous system
- Impact of green tea epigallocatechin-3-gallate on HIF1-α and mTORC2 expression in obese women: anti-cancer and anti-obesity effects?
- Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of rapamycin complex 2 (mTORC2)
- Response to Comment on “A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation”: Building a Model of the mTOR Signaling …
- Cardiomyocyte targeted overexpression of IGF1 during detraining restores compromised cardiac condition via mTORC2 mediated switching of PKCδ to PKCα
- Differential role of rapamycin in epidermis-induced IL-15-IGF-1 secretion via activation of Akt/mTORC2
- Sin1–mTORC2 signaling drives glycolysis of developing thymocytes
- c-FLIP links mTORC2 to apoptosis
- mTORC2 is the Primary Target for Simvastatin-Associated Toxicity in C2C12 Cells and in Mouse Skeletal Muscle
- Disruption of DEPTOR/mTORC1/mTORC2 signaling cascade using a novel selective mTOR kinase inhibitor AZD8055 results in growth arrest and apoptosis in …
- Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
- Efficacy of INK128, an mTORC1/mTORC2 kinase inhibitor, in breast cancer models driven by HER2-PI3K-AKT-mTOR pathway.
- Dynamic modelling of the PI3K/mTOR signalling network uncovers biphasic dependence of mTORC1 activation on the mTORC2 subunit Sin1
- OSI-027 alleviates rapamycin insensitivity by modulation of mTORC2/AKT/TGF-β1 and mTORC1/4E-BP1 signaling in hyperoxia-induced lung injury infant rats
- Myeloid Dendritic Cell-Specific mTORC2 Deficiency Enhances Alloreactive Th1 and Th17 Cell Responses and Skin Graft Rejection.: Abstract# 584
- Targeting the mTORC2 signaling complex in B cell malignancies
- Mitochondrial Bioenergetics Profile With Different Mechanistic Target of Rapamycin Complexes (mTORC1/mTORC2) Inhibitors in Pancreatic Beta-Cell Lines (Beta-TC …
- mTORC2 Drives ZFX-mediated Ganglioside Biosynthesis to Promote Breast Cancer Progression.
- Genetic immunodeficiency and autoimmune disease reveal distinct roles of Hem1 in the WAVE2 and mTORC2 complexes
- Divergent Roles of Macrophage mTORC1 and mTORC2 Signaling in Atherosclerosis
- Increased mTORC2 Pathway Activation in Lymph Nodes of Imcd-Tafro
- P-122: Increased mTORC2 pathway activation in lymph nodes of iMCD-TAFRO
- Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2, PLoS Biol
- Discovery and optimization of 5, 7-dihydro-6H-pyrrolo [2, 3-d] pyrimidin-6-one derivatives as mTORC1/mTORC2 dual inhibitors
- 3D structure determination and validation of mTORC2 using computational modeling techniques
- Role of mTORC2 and nitric oxide in bladder cancer invasion.
- Response to Comment on Sato et al. Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake …
- LST8 level controls basal p70 S6 kinase and Akt phosphorylations, and mTORC1 and mTORC2 negatively regulate each other by competing for association with …
- PTH (1‑34) activates the migration and adhesion of BMSCs through the rictor/mTORC2 pathway
- EBV LMP1-activated mTORC1 and mTORC2 Coordinately Promote Nasopharyngeal Cancer Stem Cell Formation
- TAX-TORC: A phase I trial of the combination of AZD2014 (dual mTORC1/mTORC2 inhibitor) and weekly paclitaxel in patients with solid tumors.
- The Role of CGRP Inhibition and High-Intensity Interval Training (HIIT) on mTORC2 and VEGF Gene Expression in The Hippocampal Tissues of Male Wistar Rats
- mTORC2 mediate FLCN-induced HIF2α nuclear import and proliferation of clear cell renal cell carcinoma
- OSI-027, a potent and selective small molecule mTORC1/mTORC2 kinase Inhibitor is mechanistically distinct from rapamycin
- Direct physical interaction of active Ras with mSIN1 regulates mTORC2 signaling
- Novel Upstream Activation of mTORC2 by the Innate Immune Kinase TBK1
- Targeted inhibition of mTORC1 and mTORC2 by the active-site mTOR inhibitors, PP-242 and OSI-027, has cytotoxic effects in T-cell acute lymphoblastic leukemia
- AiCAR Induces AMPK, mTORC2, and Akt Activity in Myotubes
- mTORC2 is an in vivo hydrophobic motif kinase of S6 Kinase 1.
- Prostaglandin E2 induces activation of mTORC1 and mTORC2 in mast cells: selective utilization of mTORC2 for the regulation of chemotaxis and mediator release …
- The mTORC2 Regulator homer1 Modulates Protein Levels and Sub-Cellular Localization of the CaSR in Human Osteoblasts.
- Xpln Negatively Regulates Sparc Expression By Targeting mTORC2 In Human Lung Fibroblasts
- mTORC2 mediates SDF-1α/CXCL12-induced angiogenesis
- Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTORC2 activation
- Glycolytic Bias in mTORC2 Deficient Dendritic Cells Potentiates Antigen-Specific Immunity and Accelerates Graft Rejection
- mTORC2-IRF4 mediated metabolic reprograming is essential for macrophage alternative activation
- mTORC2 controls dendritic arbor development through Akt-mTORC1-p70S6K pathway
- Abstract# 4770: Characterization of AZD8055, a potent selective inhibitor of mTORC1 and mTORC2 kinase
- Evidence for increased mTORC1 and mTORC2 signaling in human thoracic aortic aneurysm
- Influence of co-inhibiting mTORC2 and HSP90 on proliferation apoptosis of multiple myeloma cells
- Histone deacetylase inhibition with LBH589 inhibits the rapamycin insensitive Rictor-mTOR (mTORC2) complex and translation initiation factor eIF4E activation in …
- Anti-fibrotic effect of combined mTORc1 and mTORC2 inhibition in bronchiolitos obliterans
- Hitting the TORget: curcumin disrupts mTORC1 and mTORC2
- Abstract B49: mTORC2 directs breast morphogenesis through Rictor-dependent PKCα/Rac1 signaling independent of Akt
- SEX AND TISSUE SPECIFIC ROLES OF mTORC2 IN HEALTHSPAN, METABOLISM, AND SURVIVAL
- Rapamycin analogs reduce mTORC2 signaling and inhibit AKT activation in AML.
- Differential Modulation of mTORC1 and mTORC2 Signaling by Rapamycin During Pro-Arteriosclerotic Differentiation of Mesenchymal Stem Cells: 1485
- Therapeutic implications of mTORC1 and mTORC2 inhibitors in genetically heterogeneous glioblastoma
- Multi-center, single arm phase II study of the dual mTORC1/mTORC2 inhibitor vistusertib for patients with recurrent or progressive grade II-III meningiomas.
- Activin signaling regulates autophagy and cardiac aging through mTORC2
- mTORC2 combats cellular stress and potentiates immunity during viral infection
- Morphoproteomics of mTORC2 pathway as resistance signature and activated ERK and STAT3 prosurvival/antiapoptotic pathways in metastatic renal cell carcinoma …
- Rictor/mTORC2 is a critical mediator of cardiac hypertrophy and survival in response to pressure overload
- … S perturbs Sertoli cell junctions in male rats via alterations in cytoskeletal organization mediated by an imbalance between mTORC1 and mTORC2“[Sci. Total Environ …
- Is Ang II-mediated mTOR/S6K1 activation in proximal tubule cells mTORC2-dependent?
- Anticancer activity of the mTOR inhibitor (everolimus) and dual mTORC1/mTORC2 Inhibitor (AZD2014) on mouse lymphocytic leukemia both in vitro and in vivo
- Dual targeting of PI3K/mTOR leads to MEK/ERK over-activation in leiomyosarcoma through suppression of mTORC2 inhibition
- Abstract B146: XL388: a novel, selective, orally bioavailable mTORC1 and mTORC2 inhibitor that demonstrates pharmacodynamic and antitumor activity in multiple …
- Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis1, 2
- Role of Ras in Regulating mTORC2 Activity and Function in Breast Cancer Cell Migration
- The Role of mTORC1/RagGTPase and IGF1R/mTORC2/Akt Pathways and the Response of Diffuse Congenital Hyperinsulinism to Sirolimus
- mTORC2 tips the balance in cell survival
- 3-Benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2 (3H)-one suppresses FcεRI-mediated mast cell degranulation via the inhibition of mTORC2-Akt signaling
- … to: Effective-components combination improves airway remodeling in COPD rats by suppressing M2 macrophage polarization via the inhibition of mTORC2 activity
- Step1: mTORC2 activation
- Selective inhibition of mTORC2 by disruption of mLST8 scaffolding function
- Re: Inhibition of mTORC2 but not mTORC1 Up-Regulates E-Cadherin Expression and Inhibits Cell Motility by Blocking HIF-2α Expression in Human Renal Cell …
- Muscle‐specific deletion of mTORC2 (Rictor) blocks insulin stimulated Akt Ser 473 phosphorylation and impairs submaximal but not maximal insulin induced glucose …
- The Lipid Handling Capacity of Subcutaneous Fat Requires mTORC2 during Development
- Function of mTORC2 and its roles in hematological malignancies
- IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
- … Dual PI3K/mTORC1/C2 Inhibition on Long-Term Cultured Primary Human Acute Lymphoblastic Leukemia (ALL) Cells Implicate a Distinct Role of mTORC2.
- Investigating mTORC2/AKT-mediated regulation of FOXO1: a novel therapeutic strategy for chronic lymphocytic leukaemia?
- TMBIM6 regulates the assembly and activation of mTORC2
- Hepatic Activation of FOXO3 Is Associated with Pentose Phosphate Pathway Activation as Well as mTORC2-Akt Signaling and Enhances Oxidative Damage …
- mTORC2 controls potassium secretion
- mTORC2 Deficiency in CD11c+ Dendritic Cells Promotes Acute Kidney Injury
- Regulation of the mammalian target of rapamycin complex 2 (mTORC2)
- Correction: Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling
- Hyper-Activation of Mutant KRAS Drives Redox-Dependent Cell Death Involving mTORC2/Akt Signaling and Mitochondrial Morphology Changes
- mTORC2 in T Lymphocyte Development and Proliferation
- mTORC2-regulated genes transcription
- mTORC2 IN THE REGULATION OF MAMMALIAN LONGEVITY
- Evaluating the functional impacts of the BRCA1-mTORC2 interaction in breast cancer
- mTORC1 and mTORC2 regulate distinct aspects of glutamatergic synaptic transmission
- High glucose up-regulates MMP-1 expression in endothelial cells via mTORC2-PKM2 pathway
- OSI-027, a dual mTORC1/mTORC2 inhibitor, induces autophagy in cancer cells
- Abstract B187: Pharmacodynamics of OSI-027, a dual mTORC1/mTORC2 inhibitor, in tumor and surrogate tissues: Results from the expansion phase of a first-in-man …
- Development of RNAi technology to selectively inhibit mTORC2 in breast cancer
- Regulation of mammalian target of rapamycin complex 2 (mTORC2) signaling in NF2-deficient target cell types
- Promoting Fibroblast Migration with mTORC2
- Knockdown of UBXN2A Protein Induces Colorectal Cancer Metastasis Through Up-Regulation of the mTORC2 Signaling Pathway
- mTORC2 is a promising therapeutic target in epithelial ovarian cancer
- Role of ARHGEF3 as a GEF and mTORC2 Regulator.
- Genetic immunodeficiency and autoimmune disease reveals a WRC-independent role for Hem1 in mTORC2 regulation
- publisher correction: mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells
- mTORC2 in Dendritic Cells Restrains mTORC1-regulated Metabolic Activity and Their T Cell Stimulatory Function in Transplantation
- PS1174 mTORC2 ACTIVATION AND AKT NUCLEAR LOCALIZATION UNDER HYPOXIA COULD SUSTAIN THE LEUKEMIA CANCER STEM CELLS
- Analysis of mTORC2 in Regulating Aging, Metabolism and Cardiac Disease in Drosophila melanogaster
- Loss of mTORC1 & mTORC2 but nor mTORC1 or mTORC2 leads to reduction in cone function.
- Elucidating the role of mTOR complexes (mTORC1 and mTORC2) in normal haemopoiesis and in Chronic Lymphocytic Leukaemia
- mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
- mTORC2 promotes tumor growth via lipid synthesis
- mTORC2 balances Akt activation and eIF2α serine 51 phosphorylation to promote survival under stress.
- Inhibition of mTORC2 Upregulates PDGFRs Expression and Contributes to the Development of Pulmonary Hypertension
- mTORC2 Akt-ing at the Ribosome
- Enhanced pro-inflammatory profile and Th17 alloresponse by targeting mTORC2 in DC (P2138)
- mTORC2 Facilitates the Maturation of Protein Kinase C by a Phosphorylation‐Independent Mechanism
- Molecular Modeling Studies of Urea-morpholinopyrimidine Analogues as Dual Inhibitors of mTORC1 and mTORC2 Using 3D-QSAR, Topomer CoMFA and Molecular …
- mTOR Pathway in Papillary Thyroid Carcinoma: Different Contributions of mTORC1 and mTORC2
- The Role of the New mTOR Complex, mTORC2, in Autism Spectrum Disorders
- AMPK-RUNX2-mTORC2 axis involved in EMT of MDA-MB-231 breast cancer cells
- The regulation of mTORC2 kinase activity and complex integrity
- Potential Role of mTORC2 as a Therapeutic Target in Clear Cell Carcinoma of the Ovary
- Research on multiple myeloma cell apoptosis by inhibition of mTORC2 and chaperon pathways
- PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
- mTORC2 suppresses GSK3-dependent, but b-TrCP-independent, Snail degradation, contributing to positive regulation of cancer cell invasion and metastasis
- The mTORC2 target Akt is regulated in response to glutamine metabolite levels
- mTORC2 Regulates the Maturation of Protein Kinase C by Folding and Phosphorylation
- mTORC2 enhances flux through the hexosamine biosynthetic pathway by regulation of GFAT1 expression
- TRIM7, a Novel Binding Protein of the mTORC2 Component Sin1
- mTORC2 Regulation of the Hexosamine Biosynthetic Pathway (HBP) in Response to Nutrients
- Differential Metabolic Sensitivity of mTORC1-and mTORC2-Dependent Overgrowth
- The Role of mTORC2 and Ribosomal Protein S6 in Cardioprotective Signaling
- Abstract C66: Role of mTORC1 and mTORC2 in multiple myeloma and their targeting with CC214.
- mTORC1 and mTORC2 differentially regulate the development of NK cells
- Role of mTORC1 and mTORC2 during Chronic Lymphocytic Leukaemia (CLL) Initiation and Progression
- Understanding the role of mTORC1 and mTORC2 in embryonic and adult myogenesis
- DOCA-Salt-Induced Endothelial Cell Stiffening Occurs Via mTORC2/SGK1 mediated Regulation of EnNaC
- Differential regulation of mTORc1 and mTORC2 by expression of BTG2/TIS21/PC3 inhibits breast cancer cell growth and malignancy
- mTORC1 and mTORC2 expressions in the oral squmous cell carcinoma: an immunohistochemical and clinicopathological study
- P101 The effect of rapamycin in cardiac mTORC2-deficient mice under pressure overload conditions.
- The role of mTORC1 and mTORC2 in UVB‐induced
- A high throughput screening assay to identify mTORC1 and mTORC2 inhibitors
- Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
- uPAR and mTORC2 as coupled targets for therapeutics development in bladder cancer.
- To examine the combinatorial therapeutic effects of EGFR inhibitor and mTORC2 inhibitor for treatment of pancreatic cancer
- mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma
- Distinct and common functions of mTORC1 and mTORC2 in Purkinje cells
- mTORC2 controls T-cell receptor processing and surface expression during thymocyte development (115.18)
- The mTORC2 component RICTOR plays a key role in lung cancer cell growth
- Inhibition of mTORC2 induces cell cycle arrest and enhances the cytotoxicity of
- mTORC2 modulates αβT-cell receptor processing and surface expression during thymocyte development (P4414)
- Assessment of the Role of Endothelial mTORC2 in FGF2-induced Angiogenesis in vivo
- Lipid Activates mTORC1 and mTORC2 in the Absorption of Dietary Triglycerides
- Inhibition of mTORC2/Akt signaling to enhance the therapeutic potential of CD8 T cells
- mTORC2 helps brown adipose tissue fuel up
- ACTR-36. A Single Arm Phase 2 Study of the Dual Mtorc1/mTORC2 Inhibitor Vistusertib Provided on an Intermittent Schedule FOR Neurofibromatosis 2 Patients with …
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss
- Phosphorylation of Protein Kinase Akt by mTORC2 in Peripheral Blood Mononuclear Cells of Patients with Cancer and Diabetes.
- Dissecting the roles of mTORC1 and mTORC2 in the mouse heart
- mTORC2 Regulates Energy Metabolism, Proliferation And Survival Of Vascular Smooth Muscle Cells In Pulmonary Arterial Hypertension
- Regulation of FoxO1 by mTORC2 negatively controls Toll-like receptor responses (111.24)
- Comment on prognostic and therapeutic implications of mTORC2 and rictor expression in human breast cancer
- Characterisation of a new mechanism of ATR/Chk1 regulation in breast cancer: role of mTORC2
- Hepatic activation of FOXO3 regulates mTORC2-Akt and enhances oxidative damage-associated hepatocellular carcinogenesis
- UBXN2A inhibits tumor invasion and metastasis by targeting the mTORC2-VEGF pathway
- Interaction with phospho-eIF4E commits S6 Kinase 1 for mTORC2 and PHLPP1 mediated activation
- Therapeutic Suppression of mTORC2 Signaling Reduces Salt-induced Hypertension and Kidney Injury in SS Rats
- … MODELS OF PULMONARY HYPERTENSION: NOVEL TARGETS AND PATHWAYS: Dual Mtorc1/mTORC2 Inhibitor Pp242 Induces mTORC2-Specific Bim-Dependent …
- mTORC1 and mTORC2 interact with each other to regulate NK cells maturation and effector functions
- The role of mTORC2 in mammary morphogenesis and HER2-mediated tumorigenesis
- Myeloid DC-specific mTORC2 deficiency enhances Th1 and Th17 immunologic responses (IRC5P. 472)
- Comment on Sato et al. Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal …
- Effects of mTORC2 on Ovine Conceptus Elongation and Implantation.
- Manganese superoxide dismutase regulates mTORC2 mediated UVB-induced mitophagy
- 1806-P: Vitamin D Deficiency Impairs mTORC2/Akt Signaling through Downregulating SIRT1 and Results in Increased Hepatic Gluconeogenesis
- mTORC1 and mTORC2 regulation of tumor cell growth and survival assessed using small interfering RNA
- Rictor/mTORC2 regulates mouse T-all development via FoxO3a
- mTORC2 activation determines the retinal ganglion cell fate via Akt signaling after autophagy induction in traumatic optic nerve injury
- Inflammation-induced mTORC2-Akt-mTORC1 signaling promotes macrophage foam cell formation
- Interrogating cellular metabolism reveals mTORC2 as a new biomarker to stratify epidermal growth factor receptor-mutant non-small cell lung cancer
- TAK228, a kinase inhibitor of mTORC1 and mTORC2, is highly effective in ER+ breast cancer model
- MEDIATING THE mTORC2-DEPENDENT SURVIVAL RESPONSE TO UVB EXPOSURE THROUGH NEGATIVE REGULATION OF THE TUMOR SUPRESSOR …
- mTORC2 Regulates Adaptive Cell Fate Programs and Protects Mesenchymal Progenitors From Osteoblastic Transformation.: Abstract# C1572
- The Differential Regulation of Monocyte Derived and Tissue Resident Alveolar Macrophages by mTORC2 Promotes Lung Fibrosis
- The mTORC2/PKC pathway sustains compensatory insulin secretion of pancreatic β cells in response to metabolic stress General subjects
- Disruption of mTORC2 Integrity Underlies Increased Myocardial Susceptibility to Ischemia/reperfusion Injury in Chronic Renal Failure
- Chaetoglobosin K, a dual Akt and JNK inhibitor, modulates Akt phosphorylation in an mTORC2 independent manner
- mTORC1 and mTORC2 regulate cell proliferation in Glioblastoma multiforme
- mTORC2 negatively regulates DC PD-L1 and IL-10 through SOCS3 and STAT3 (172.34)
- mTORC2 protein-mediated protein kinase B (Akt) serine 473 phosphorylation is
- PINK1/BRPK inhibits apoptotic cell death and enahances cellular invasiveness through an activation of mTORC2 pathway
- Hyperuricemia driven pancreatic β-cell dysfunction through Rictor, a subunit of mTORC2
- Rictor/mTORC2 drives formation, progression and therapeutic resistance of HER2-amplified breast cancers
- Extracellular nutrients are required to maintain oncogenic signaling in brain cancer–a critical role for mTORC2
- Abstract C270: In vitro and in vivo antitumor activity of DCBCI0901, a potent PI3K/mTORC1/mTORC2 inhibitor.
- Endothelial mTORC2 deficiency inhibits tumor angiogenesis, tumor progression and metastasis in non-small cell lung cancer (NSCLC)
- Abstract A118: The mTORC2 component Rictor directs branching morphogenesis and survival in the mammary epithelium
- Deletion Of The Alpha Subunit Of EnNaC And mTORC2 Inhibition Attenuate DOCA-salt-induced Endothelial Cell And Vascular Stiffness.
- HYPER-ACTIVATION OF MUTANT KRAS DRIVES REDOX-DEPENDENT CELL DEATH INVOLVING mTORC2/AKT SIGNALING AND MITOCHONDRIAL …
- Dyrk1b Displaces Fkbp12 from mTORC2, Causes its Activation and Triggers De Novo Lipogenesis: Implications for the Treatment of Diet-Induced Fatty Liver Disease
- The Impact of mTORC2 Signaling on the Initiation and Progression of KRAS-Driven Pancreatic Neoplasias: A Dissertation
- MTORC1 and mTORC2 control normal and neoplastic mast cell homoeostasis through regulation of cell division rather than maintenance of survival (151.20)
- Anti-CD44 Antibodies Inhibit Both mTORC1 and mTORC2 Activities in Acute Myeloid Leukemia.
- Isolated Human Lung Alveolar Epithelial Cells In Culture Change In MTORC1 And mTORC2 Expression And Signaling With Time
- The role of endothelial Rictor (mTORC2) in angiogenesis in vivo and in vitro
- AB0115 Influence of mTORC2/akt on the cell viability in rheumatoid arthritis fibroblast-like synoviocytes
- Rictor/mTORC2 regulates blood-testis barrier and spermatogenesis in mice
- Cytochrome p450 3a5 manipulates the progression of hepatocellular carcinoma via selectively targeting ros/mTORC2/p-akt (s473) signaling
- Sin1-mTORC2 regulation of the ontogeny and function of innate lymphoid cells
- Abstract A24: CD146-Rictor interaction reveals a pathway linking mTORC2 activation with extracellular stimuli
- The role of hypothalamic mTORC1 and adipose tissue mTORC2 in organismal energetics
- Abstract C59: Estradiol and mTORC2 orchestrate to enhance prostaglandin biosynthesis andtumorigenesis in tuberous sclerosis complex
- Rictor Acetylation Promotes mTORC2-mediated Akt Phosphorylation
- mTORC2 controls neuron size and Purkinje cell morphology independent of mTORC1
- Abstract B1: Dual mTORC1/mTORC2 inhibition limits tumor growth, VEGF production and vascular regrowth
- Retraction: Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell …
- Targeting the mTORC2/HIF-2alpha/p53 pathway in clear cell renal cell carcinoma.
- Rictor plays a critical role in bone mass and strength with the involvement of mTORC2 pathway in osteoblasts
- Role for Rictor/mTORC2 Signaling in Mediating TGFb1‐induced Fibroblast Activation and Kidney Fibrosis
- MAPKAP1 (Sin1), a Key Component of the mTORC2 Complex, Confers Resistance to Sorafenib and Correlates with Adverse Clinical Outcomes in Acute Myeloid …
- mTORC2 directs breast morphogenesis through Rictor-dependent PKCα/Rac1 signaling independent of Akt
- The combination of the dual mTORC1/mTORC2 inhibitor AZD2014 and paclitaxel in human ovarian cancer models
- Epstein Barr virus-encoded LMP1 activates the mTORC2 signaling pathway to reprogram glucose metabolism in nasopharyngeal epithelial cell
- PI3K/RICTOR-mTORC2 axis as a driver of prognosis and potential druggable target in squamous cell lung carcinoma (SqCLC)
- Discovery of a new class of mTOR inhibitors reveals rapamycin-resistant outputs of mTORC1 and mTORC2
- The Calcineurin Variant CnAb1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation
- Brain without Rictor: mTORC2 signaling regulates central dopamine homeostasis
- Leucine Pulses during Long‐term Continuous Feeding Enhance mTORC1 and mTORC2 Activation in Skeletal Muscle of Neonatal Pigs
- Regulation of endothelial cell proliferation of infantile hemangioma through mTORC2 and NDRG1 signaling pathways
- Strategies to’Hydrophobize’Systemic siRNA Vectors and Selectively Inhibit mTORC2 in Breast Tumors Through RNA Interference
- Abstract IA11: Targeting PI3K-mTOR signaling in glioblastoma: A central role for mTORC2 in drug resistance and metabolic reprogramming
- Targeting PI3K/mTOR leads to MEK/ERK over-activation in pancreatic cancer through suppression of mTORC2
- Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo
- The role of mTORC1 and mTORC2 in hypoxia-induced HIF-1 α stabilization and endothelial proliferation
- A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation xmpMM: DocumentID: uuid: 13a28f85-cbc5-4bad-9317-04e8711240fe Last-Save …
- Impacto del té verde epigalocatequina-3-galato en la expresión de HF1-α y mTORC2 en mujeres obesas:¿ efectos anticancerígenos y antiobesidad?
- Potassium Can Regulate Its Own Excretion in Collecting Duct Cells: Role of mTORC2, SGK1 and ENaC
- Inhibitory effects of resveratrol on the proliferation, migration and angiogenesis of HUVECs through targeting mTORC2/Rictor
- Ubiquitin C-Terminal Hydrolase L1 Balances mTORC1 and mTORC2 Activities in Myotubes and Oxidative Muscle Fibers
- Abstract B10: Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in tuberous sclerosis complex
- Female Sex-related Cardioprotection Relies on Estrogen Receptor-beta, mTORC1, and mTORC2 Activities
- Myeloid dendritic cell-specific mTORC2 deficiency enhances Th1 and Th17 cell responses and inhibits B16 melanoma growth (TUM6P. 959)
- Protein Kinase C-Theta Interacts with mTORC2 and Vimentin to Limit Regulatory T-Cell Function
- The mTORC1/mTORC2 Inhibitor AZD2014 Enhances the Radiosensitivity of Glioblastoma Stem-like Cells
- Hepatic c-Jun overexpression metabolically reprograms cancer cells through mTORC2/AKT pathway
- Akt-mTORC2 signaling underlies cellular addiction to HER3 signaling in HER2-amplified cancers.
- … TARGETS IN PULMONARY HYPERTENSION: INSIGHTS FROM TRANSLATIONAL AND PRECLINICAL STUDIES: Nox4 Regulates mTORC2-Akt Signaling And …
- Fatty acid elongase‐5 (Elovl5) regulates the mTORC2‐FoxO1 pathway in obese‐diabetic C57BL/6J mice
- mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer
- The mTORC2 Component Rictor Confers Cisplatin Resistance in Human Ovarian Cancer Cells
- H2S‐induced cardiac protection is caused by activation of mTORC2/Akt/Bim pathway in an isolated rat heart ischemia/reperfusion model
- KLF4 Regulates Self-Renewal of Leukemic Stem Cells in Chronic Myeloid Leukemia By Repressing Gbl Expression and Altering mTORC2 Activity
- GW28-e1056 The Valosin-Containing Protein Attenuates Chronic Pressure Overload-induced Cardiac Remodeling and Heart Failure via Activating mTORC2 Pathway
- Concomitant Inhibition of mTORC1 and mTORC2 in Dendritic Cells Reduces SOCS3 Expression Resulting in Enhanced Immunoregulatory PD-L1 Expression and IL …
- Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.: Phospholipase D and mTOR in myogenesis
- mTORC1 inhibition with rapamycin or LY294002 alone but not in combination leads to AKT phosphorylation via mTORC2 in melanoma cells
- Type‐I interferon‐mediated Akt/mTORC2 signaling regulates autophagy and inflammasome activation in mouse liver injury/sepsis model
- The Valosin-containing Protein Attenuates Chronic Pressure Overload-induced Cardiac Remodeling and Heart Failure via Activating mTORC2 Pathway
- An insulin-independent pathway including β-adrenoceptors and mTORC2 that translocates GLUT4 and increases glucose uptake in skeletal muscle
- Rapamycin protects livers from ischemia and reperfusion Injury via both autophagy induction and mTORC2-Akt activation
- mTORC2 Promotes Lipid Storage and Suppresses Thermogenesis in Brown Adipose Tissue in Part Through AKT-Independent Regulation of FoxO1: A Dissertation
- MTORC1 AND mTORC2 PLAY DIFFERENT ROLES IN THE FUNCTIONAL SURVIVAL OF TRANSPLANTED ADIPOSE-DERIVED STROMAL CELLS IN HINDLIMB …
- Selective regulation of macrophages differentiation and function by mTOR and metabolic reprogramming: mTORC2 regulates peritoneal tissue-resident macrophages …
- A phase i dose-escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC-223 in …
- Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration
- Abstract A2: Selective inhibition of mTORC1/mTORC2 sensitizes prostate cancer cells to the effects of AR or IGF-1R/IR antagonists, providing an approach to …
- Regulating effect of recombinant lentivirus silencing rictor gene on mTORC2/SGK1 signal pathway and pulmonary alveolar epithelial sodium ion channel
- Abstract B27: Superoxide anion O2.-mediated activation of mTORC2 by estrogen receptor in breast cancer cells: Role of acetylation dependent inhibition of MnSOD
- Abstract LB-134: mTORC2 regulates the amount of cell surface receptors via its role in protein processing.
- … Integrin Mediates Insulin-like Growth Factor-1 Induction of Aortic Smooth Muscle Alpha-Actin Expression Through a PI3K/mTORC2/eIF4E Translational Mechanism
- Conditional Ablation of the mTORC2 Component Rictor in Male Germline Reveals a Differential Requirement for Ensuring Spermatogonia Differentiation and …
- PO-484 Immunohistochemical analysis of mTORC1 and mTORC2-related proteins in renal cell carcinoma of kidney transplant recipients
- CD3/CD28 Co-Stimulated Activation of PI3K-mTORC2-AKT Metabolic Programming Augments Granzyme B Expression and Direct Cytotoxicity in Expanded Human …
- FT-1518, a new generation selective and potent mTORC1 and mTORC2 inhibitor: an in vitro and in vivo profile
- 133-OR: Dyrk1b Is a Nutrient-Sensing Protein That Triggers De Novo Lipogenesis by Activating mTORC2 Complex: Implication for the Treatment of Type 2 Diabetes
- Corrigendum: Omega-3 Polyunsaturated Fatty Acids Attenuate Fibroblast Activation and Kidney Fibrosis Involving mTORC2 Signaling Suppression
- Abstract# 1839: OXA-01, a selective inhibitor of mTORC1/mTORC2, enhances apoptosis induced by chemotherapeutic agents through inhibition of Akt …
- mTOR complex 2 (mTORC2) regulation of hepatic gene expression
- 300 A COMPARISON OF KU0063794, A DUAL MTORC1 AND mTORC2 INHIBITOR, AND TEMSIROLIMUS IN PRECLINICAL RENAL CELL CARCINOMA MODELS
- The mammalian target of rapamycin complex 2 (mTORC2) negatively regulates the innate inflammatory response
- Abstract# 3711: Superior cellular anti-tumor effects of a dual mTORC1/mTORC2 kinase inhibitor OXA-01 relative to the mTORC1 inhibitor rapamycin
- Abstract# 2371: A VEGF-C/Neuropilin 2 axis induces a mTORC2 mediated pathway to protect prostate cancer cells from oxidative stress.
- Abstract LB-207: mTORC2/Akt signaling is modulated by noncanonical mitochondrial Notch1/PINK1 interaction in myc-amplified medulloblastoma tumorigenesis
- mTOR complex 2 (mTORC2) positively regulates Mcl-1 stability by suppressing GSK3-dependent and FBXW7-mediated proteasomal degradation of Mcl-1
- Activation of mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) is required for retinal ganglion cell dendrite regeneration after axonal injury.
- Abstract# 2856: mTORC1 and mTORC2 involvement in activation of MAPK pathway via a PI3K/AKT-dependent feedback loop influences glioblastoma multiforme …
- Abstract P5-07-06: A novel non-canonical Notch1-IKKα-mTORC2-AKT pathway maintains survival in triple negative breast cancer cells and cancer stem-like cells
- Mechanistic Target of Rapamycin Complex 2 (mTORC2) regulation of the primary human trophoblast cell transcriptome
- Abstract# 4762: The mTORC2 complex regulates C2C12 myoblast fusion through a ROCK-1-dependent pathway
- … MAMMALIAN TARGET OF RAPAMYCIN SIGNALING COMPLEX-2 (mTORC2): ROLE OF SUPEROXIDE ANION IN ACTIVATION OF mTORC2 IN BREAST CANCER …
- Abstract A16: Suppressor of morphogenesis in genitalia 1 (SMG1) is a novel negative regulator of mammalian target of rapamycin complex 2 (mTORC2)
- 141 PI3K REGULATES P27 THROUGH mTORC2 IN RENAL CELL CARCINOMA
- The Combination of Sorafenib and Everolimus abrogates mTORC-1 and mTORC2 up-regulation in preclinical models of Osteosarcoma.
- Abstract# SY27-1: Discovery and development of small molecule inhibitors of mTORC1 and mTORC2 as potential anti-cancer agents
- 475-P: Renal Loss of mTORC2 Is Associated with Improved Diabetic Nephropathy in Type 1 Diabetes
- MicroRNA-101 as a potential regulator of mTORC2 and HIF-2a in renal cell carcinoma
- … IN HUMAN RENAL CELL CARCINOMA ACHN CELLS IS MEDIATED BY CONSTITUTIVE ACTIVATION OF SIGNAL TRANSDUCTION PATHWAYS VIA mTORC2
- Rictor Oxidation and Disruption of the Mammalian Target of Rapamycin Complex 2 (mTORC2) Links Mitochondrial Oxidative Stress to Insulin Resistance in …
- The Role of Sin 1-mTORC2 in the Regulation of T Cell Homeostasis
- IKBKE activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 to sustain malignant transformation
- Calpain-2 Activates Akt via the TGF~ 1-mTORC2 Pathway in Pulmonary Artery Smooth Muscle Cells
- … THE TUBULAR RENIN-ANGIOTENSIN SYSTEM AND PREVENTION BY ANGIOTENSIN II RECEPTOR BLOCKADE13 mTORC2 REGULATES ENDOTHELIAL CELL …
- Abstract# 444: Molecular and clinical characterization of RICTOR (mTORC2) as a candidate oncogene in hepatocellular carcinoma
