POLYPHENOLS AS COVID-19 TREATMENT & PREVENTION
August 3, 2022GUT BRAIN AXIS
August 3, 2022
- The role of CDK5 /P25 formation/inhibition in neurodegeneration.
- A decade of CDK5
- CDK5 deregulation in the pathogenesis of Alzheimer’s disease
- Conversion of p35 to p25 deregulates CDK5 activity and promotes neurodegeneration
- The CDK5 /p35 kinase is essential for neurite outgrowth during neuronal differentiation.
- The p35/CDK5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity
- CDK5 -mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis
- p35, the neuronal-specific activator of cyclin-dependent kinase 5 (CDK5 ) is degraded by the ubiquitin-proteasome pathway
- Cables links CDK5 and c-Abl and facilitates CDK5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth
- Aberrant CDK5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
- Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by CDK5
- CDK5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
- Effects of chronic exposure to cocaine are regulated by the neuronal protein CDK5
- Phosphorylation of DARPP-32 by CDK5 modulates dopamine signalling in neurons
- CDK5 serves as a major control point in neurotransmitter release
- Mice lacking p35, a neuronal specific activator of CDK5 , display cortical lamination defects, seizures, and adult lethality
- Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5 /P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer’s Disease: A …
- Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin‐dependent kinases cdc2, cdk2 and CDK5
- Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and CDK5
- CDK5 is a key factor in tau aggregation and tangle formation in vivo
- Fyn and CDK5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex
- Semaphorin3A signalling is mediated via sequential CDK5 and GSK3β phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying …
- Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of CDK5
- Structure and regulation of the CDK5 -p25nck5a complex
- Deregulation of CDK5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions
- CDK5 /p35 regulates neurotransmitter release through phosphorylation and downregulation of P/Q-type voltage-dependent calcium channel activity
- Inhibition of tau phosphorylating protein kinase CDK5 prevents β-amyloid-induced neuronal death
- A Jekyll and Hyde kinase: roles for CDK5 in brain development and disease
- An isoform of the neuronal cyclin-dependent kinase 5 (CDK5 ) activator
- Silencing of CDK5 reduces neurofibrillary tangles in transgenic alzheimer’s mice
- NUDEL is a novel CDK5 substrate that associates with LIS1 and cytoplasmic dynein
- … specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5 …
- Accumulation of cyclin-dependent kinase 5 (CDK5 ) in neurons with early stages of Alzheimer’s disease neurofibrillary degeneration
- CDK5 is essential for synaptic vesicle endocytosis
- CDK5 : a multifaceted kinase in neurodegenerative diseases
- CDK5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors
- CDK5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration
- The protein kinase CDK5 : structural aspects, roles in neurogenesis and involvement in Alzheimer’s pathology
- S-Nitrosylation activates CDK5 and contributes to synaptic spine loss induced by β-amyloid peptide
- Serine 732 phosphorylation of FAK by CDK5 is important for microtubule organization, nuclear movement, and neuronal migration
- CDK5 regulates the organization of Nestin and its association with p35
- CDK5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons
- Antidiabetic actions of a non-agonist PPARγ ligand blocking CDK5 -mediated phosphorylation
- CDK5 -dependent regulation of glucose-stimulated insulin secretion
- Transcriptional regulation of β-secretase by p25/CDK5 leads to enhanced amyloidogenic processing
- Mechanism of CDK5 /p25 binding by CDK inhibitors
- Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling
- CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression
- A CDK5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons
- p39 activates CDK5 in neurons, and is associated with the actin cytoskeleton
- ERK induces p35, a neuron-specific activator of CDK5 , through induction of Egr1
- Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the CDK5 /p35 pathway
- CDK5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity
- An unusual member of the Cdk family: CDK5
- CDK5 is involved in neuregulin-induced AChR expression at the neuromuscular junction
- Deregulation of HDAC1 by p25/CDK5 in neurotoxicity
- A model of the complex between cyclin-dependent kinase 5 and the activation domain of neuronal CDK5 activator
- Role of CDK5 -mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson’s disease
- Involvement of aberrant glycosylation in phosphorylation of tau by CDK5 and GSK-3β
- Synaptic roles of CDK5 : implications in higher cognitive functions and neurodegenerative diseases
- A nestin scaffold links CDK5 /p35 signaling to oxidant‐induced cell death
- CDK5 -mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson’s disease
- Regulation of N-cadherin-mediated adhesion by the p35–CDK5 kinase
- CDK5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration
- Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and CDK5 and its effects on physiological functions
- A novel CDK5 ‐dependent pathway for regulating GSK3 activity and kinesin‐driven motility in neurons
- Deregulated CDK5 promotes oxidative stress and mitochondrial dysfunction
- Phosphorylation of MEK1 by CDK5 /p35 down-regulates the mitogen-activated protein kinase pathway
- Deregulated CDK5 activity is involved in inducing Alzheimer’s disease
- A survey of CDK5 activator p35 and p25 levels in Alzheimer’s disease brains
- Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a CDK5 -dependent mechanism
- Calpain-regulated p35/CDK5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2
- CDK5 regulates STAT3 activation and cell proliferation in medullary thyroid carcinoma cells
- A CDK5 –p35 stable complex is involved in the β-amyloid-induced deregulation of CDK5 activity in hippocampal neurons
- CDK5 phosphorylates p53 and regulates its activity
- A cdc2-related kinase PSSALRE/CDK5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule
- CDK5 is essential for adult hippocampal neurogenesis
- The role of CDK5 in neuroendocrine thyroid cancer
- CDK5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors
- Nuclear localization of CDK5 is a key determinant in the postmitotic state of neurons
- CDK5 -mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion
- CDK5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn
- Deregulation of CDK5 , hyperphosphorylation, and cytoskeletal pathology in the Niemann–Pick type C murine model
- Role of protein phosphatase-2A and-1 in the regulation of GSK-3, CDK5 and cdc2 and the phosphorylation of tau in rat forebrain
- CDK5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex
- CDK5 behind the wheel: a role in trafficking and transport?
- Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth
- Cophosphorylation of amphiphysin I and dynamin I by CDK5 regulates clathrin-mediated endocytosis of synaptic vesicles
- Phosphorylation of Pak1 by the p35/CDK5 kinase affects neuronal morphology
- Divergent roles of GSK3 and CDK5 in APP processing
- Potentiation of GSK-3-catalyzed Alzheimer-like phosphorylation of human tau by CDK5
- Critical role of CDK5 and Polo-like kinase 2 in homeostatic synaptic plasticity during elevated activity
- Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau
- A hippocampal CDK5 pathway regulates extinction of contextual fear
- Region‐specific expression of cyclin‐dependent kinase 5 (CDK5 ) and its activators, p35 and p39, in the developing and adult rat central nervous system
- CDK5 : multitasking between physiological and pathological conditions
- Phosphorylation of ATM by CDK5 mediates DNA damage signalling and regulates neuronal death
- Talin phosphorylation by CDK5 regulates Smurf1-mediated talin head ubiquitylation and cell migration
- CDK5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK
- Phosphorylation of human tau protein by microtubule‐associated kinases: GSK3β and CDK5 are key participants
- Extraneuronal activities and regulatory mechanisms of the atypical cyclin-dependent kinase CDK5
- The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase CDK5 and by glucose
- Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/CDK5 and p25/CDK5
- CDK5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats
- CDK5 modulates cocaine reward, motivation, and striatal neuron excitability
- Roscovitine regulates invasive breast cancer cell (MDA-MB231) proliferation and survival through cell cycle regulatory protein CDK5
- The cyclin-dependent kinase CDK5 controls multiple aspects of axon patterning in vivo
- Stabilization and activation of p53 induced by CDK5 contributes to neuronal cell death
- Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through CDK5 /p35 pathway
- PKA modulates GSK-3β-and CDK5 -catalyzed phosphorylation of tau in site-and kinase-specific manners
- A peptide derived from cyclin‐dependent kinase activator (p35) specifically inhibits CDK5 activity and phosphorylation of tau protein in transfected cells
- Glutathione‐S‐transferase P1 is a critical regulator of CDK5 kinase activity
- Specific inhibition of p25/CDK5 activity by the CDK5 inhibitory peptide reduces neurodegeneration in vivo
- Processing of CDK5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells
- CDK5 regulates accurate maturation of newborn granule cells in the adult hippocampus
- Involvement of CDK5 /p25 in digoxin-triggered prostate cancer cell apoptosis
- A truncated peptide from p35, a CDK5 activator, prevents Alzheimer’s disease phenotypes in model mice
- Neurodegeneration in an Aβ‐induced model of Alzheimer’s disease: the role of CDK5
- Essential role of cytoplasmic CDK5 and Prx2 in multiple ischemic injury models, in vivo
- RNAi screen of the druggable genome identifies modulators of proteasome inhibitor sensitivity in myeloma including CDK5
- A 24-residue peptide (p5), derived from p35, the CDK5 neuronal activator, specifically inhibits CDK5 -p25 hyperactivity and tau hyperphosphorylation
- Dissociation of tau toxicity and phosphorylation: role of GSK-3β, MARK and CDK5 in a Drosophila model
- Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction
- Cyclin I activates CDK5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells
- Identification of functional domains in the neuronal CDK5 activator protein
- AβPP induces CDK5 -dependent tau hyperphosphorylation in transgenic mice Tg2576
- Migration defects of CDK5 −/− neurons in the developing cerebellum is cell autonomous
- TrkB phosphorylation by CDK5 is required for activity-dependent structural plasticity and spatial memory
- Cloning of three novel neuronal CDK5 activator binding proteins
- Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates CDK5 in a mouse model of AD
- MAP1B phosphorylation is differentially regulated by CDK5 /p35, CDK5 /p25, and JNK
- Tau phosphorylation by CDK5 and Fyn in response to amyloid peptide Aβ 25–35: Involvement of lipid rafts
- The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 CDK5 activator
- CDK5 , a therapeutic target for Alzheimer’s disease?
- Decreased cyclin-dependent kinase 5 (CDK5 ) activity is accompanied by redistribution of CDK5 and cytoskeletal proteins and increased cytoskeletal protein …
- Identification of the N‐terminal functional domains of CDK5 by molecular truncation and computer modeling
- Deregulated CDK5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death
- c-Abl tyrosine kinase modulates tau pathology and CDK5 phosphorylation in AD transgenic mice
- Cyclin E constrains CDK5 activity to regulate synaptic plasticity and memory formation
- Crosstalk between CDK5 and GSK3β: Implications for Alzheimer’s disease
- Cyclin dependent kinase 5, CDK5 , is a positive regulator of myogenesis in mouse C2 cells
- Recent advances in understanding the roles of CDK5 in synaptic plasticity
- Making a neuron: CDK5 in embryonic and adult neurogenesis
- Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models
- CDK5 suppresses the neuronal cell cycle by disrupting the E2F1–DP1 complex
- Regulation of DARPP‐32 dephosphorylation at PKA‐and CDK5 ‐sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase‐2A
- Cyclin‐dependent protein kinase 5 (CDK5 ) and the regulation of neurofilament metabolism
- Mice lacking phosphatase PP2A subunit PR61/B’δ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β
- The role of the CDK5 –p35 kinase in neuronal development
- Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the CDK5 inhibitory peptide
- CDK5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity
- Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of CDK5 in bovine brain
- Enterovirus 71 triggering of neuronal apoptosis through activation of Abl‐CDK5 signalling
- Cyclin‐dependent kinase 5 (CDK5 ) activation requires interaction with three domains of p35
- Control of cyclin‐dependent kinase 5 (CDK5 ) activity by glutamatergic regulation of p35 stability
- CDK5 -mediated phosphorylation of CRMP-2 enhances its interaction with CaV2. 2
- Going out of the brain: non-nervous system physiological and pathological functions of CDK5
- Activation of cyclin-dependent kinase 5 (CDK5 ) in primary sensory and dorsal horn neurons by peripheral inflammation contributes to heat hyperalgesia
- CDK5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-β and prion peptides
- S-nitrosylation of cyclin-dependent kinase 5 (CDK5 ) regulates its kinase activity and dendrite growth during neuronal development
- Cellular senescence requires CDK5 repression of Rac1 activity
- Analysis of the expression, distribution and function of cyclin dependent kinase 5 (CDK5 ) in developing cerebellar macroneurons
- A CDK5 -dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons
- p25/CDK5 -mediated retinoblastoma phosphorylation is an early event in neuronal cell death
- Expression of CDK5 /p35 in resected patients with non-small cell lung cancer: relation to prognosis
- Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer’s disease
- CDK5 : one of the links between senile plaques and neurofibrillary tangles?
- CDK5 /p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration
- Balance of calcineurin Aα and CDK5 activities sets release probability at nerve terminals
- Colocalization and fluorescence resonance energy transfer between CDK5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary …
- CDK5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway
- Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by CDK5 and cdc2
- p35/CDK5 binds and phosphorylates β‐catenin and regulates β‐catenin/presenilin‐1 interaction
- CDK5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival
- Spatial learning impairment, enhanced CDK5 /p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1
- CDK5 : mediator of neuronal death and survival
- The brain-specific activator p35 allows CDK5 to escape inhibition by p27Kip1 in neurons.
- The role of CDK5 -mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death
- Angiostatin‐induced inhibition of endothelial cell proliferation/apoptosis is associated with the down‐regulation of cell cycle regulatory protein CDK5
- p35/CDK5 pathway mediates soluble amyloid‐β peptide‐induced tau phosphorylation in vitro
- Myocardin-related transcription factors regulate the CDK5 /Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development
- Drebrin contains a cryptic F-actin–bundling activity regulated by CDK5 phosphorylation
- Inhibition of CDK5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine
- Mitotic-like tau phosphorylation by p25-CDK5 kinase complex
- CDK5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons
- Targeting CDK5 activity in neuronal degeneration and regeneration
- CDK5 : a new player in pain signaling
- Disruption of CDK5 -associated phosphorylation of residue threonine-161 of the δ-opioid receptor: impaired receptor function and attenuated morphine antinociceptive …
- Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems
- CDK5 regulates differentiation of oligodendrocyte precursor cells through the direct phosphorylation of paxillin
- CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model
- Level of CDK5 expression predicts the survival of relapsed multiple myeloma patients
- The CDK5 kinase regulates the STAT3 transcription factor to prevent DNA damage upon topoisomerase I inhibition
- Activation of the calpain/CDK5 /p25 pathway in the girus cinguli in Parkinson’s disease
- Phosphorylation of the high molecular weight neurofilament protein (NF-H) by CDK5 and p35
- Nuclear envelope dispersion triggered by deregulated CDK5 precedes neuronal death
- Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation
- Cyclin-dependent kinase 5 (CDK5 ) activation domain of neuronal CDK5 activator: Evidence of the existence of cyclin fold in neuronal CDK5 a activator
- Interaction of Cyclin-dependent Kinase 5 (CDK5 ) and Neuronal CDK5 Activator in Bovine Brain (∗)
- Recent evidence regarding a role for CDK5 dysregulation in Alzheimer’s disease
- CDK5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer’s disease
- Defining CDK5 ligand chemical space with small molecule inhibitors of tau phosphorylation
- Kainate induces AKT, ERK and CDK5 /GSK3β pathway deregulation, phosphorylates tau protein in mouse hippocampus
- Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5 , and GSK-3 inhibition by paullones
- Target-derived GFRα1 as an attractive guidance signal for developing sensory and sympathetic axons via activation of CDK5
- The atypical kinase CDK5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes
- The protective effects of tanshinone IIA on neurotoxicity induced by β-amyloid protein through calpain and the p35/CDK5 pathway in primary cortical neurons
- Potential roles of CDK5 /p35 and tau protein in hippocampal mossy fiber sprouting in the PTZ kindling model.
- Cyclin-dependent kinase 5 (CDK5 ) and neuron-specific CDK5 activators
- CDK5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a …
- Inhibition of the CDK5 /p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson’s disease
- The CDK5 repressor CDK5 RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA
- GDNF hyperalgesia is mediated by PLCγ, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4‐binding protein versican
- Oxidative stress promotes τ dephosphorylation in neuronal cells: the roles of CDK5 and PP1
- The CDK5 -p35 kinase associates with the Golgi apparatus and regulates membrane traffic
- Schizophrenia is associated with dysregulation of a CDK5 activator that regulates synaptic protein expression and cognition
- Abl deregulates CDK5 kinase activity and subcellular localization in Drosophila neurodegeneration
- CDK5 -mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1
- LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a CDK5 -dependent manner
- Identification of a neuronal CDK5 activator-binding protein as CDK5 inhibitor
- Phosphorylation of p35 and p39 by CDK5 determines the subcellular location of the holokinase in a phosphorylation-site-specific manner
- CDK5 -mediated phosphorylation of Axin directs axon formation during cerebral cortex development
- The serotonin receptor 7 promotes neurite outgrowth via ERK and CDK5 signaling pathways
- Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine
- No difference in kinetics of tau or histone phosphorylation by CDK5 /p25 versus CDK5 /p35 in vitro
- Identification of nuclear import mechanisms for the neuronal CDK5 activator
- Overexpression of a Novel Activator of PAK4, the CDK5 Kinase–Associated Protein CDK5 RAP3, Promotes Hepatocellular Carcinoma MetastasisCDK5 RAP3 Activates …
- Sustained cell polarity and virulence in the phytopathogenic fungus Ustilago maydis depends on an essential cyclin-dependent kinase from the CDK5 /Pho85 family
- Activity-dependent phosphorylation of neuronal Kv2. 1 potassium channels by CDK5
- L6 myoblast differentiation is modulated by CDK5 via the PI3K–AKT–p70S6K signaling pathway
- Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype
- Elevation of p-NR2AS1232 by CDK5 /p35 contributes to retinal ganglion cell apoptosis in a rat experimental glaucoma model
- Class 3 semaphorin mediates dendrite growth in adult newborn neurons through CDK5 /FAK pathway
- Identification of tyrosine hydroxylase as a physiological substrate for CDK5
- Quantitative measurement of in vivo phosphorylation states of CDK5 activator p35 by Phos-tag SDS-PAGE
- Role of CDK5 in neuronal signaling, plasticity, and drug abuse
- Mammalian CDK5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase
- The role of CDK5 and GSK3B kinases in hyperphosphorylation of microtubule associated protein tau (MAPT) in Alzheimer’s disease
- The expression of CDK5 , p35, p39, and CDK5 kinase activity in developing, adult, and aged rat brains
- CDK5 nuclear localization is p27-dependent in nerve cells: implications for cell cycle suppression and caspase-3 activation
- … of neuronal Cdc2-like kinase from bacteria-expressed CDK5 and an active fragment of the brain-specific activator: Kinase activation in the absence of CDK5 …
- Phosphorylation of protein phosphatase inhibitor-1 by CDK5
- Involvement of calpain/p35-p25/CDK5 /NMDAR signaling pathway in glutamate-induced neurotoxicity in cultured rat retinal neurons
- CDK5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint
- Role of CDK5 in drug abuse and plasticity
- Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (CDK5 )-dependent Alzheimer phosphorylation sites
- CDK5 regulates the size of an axon initial segment-like compartment in mushroom body neurons of the Drosophila central brain
- Enhanced CDK5 activity and p35 translocation in the ventral striatum of acute and chronic methamphetamine-treated rats
- Basolateral amygdala CDK5 activity mediates consolidation and reconsolidation of memories for cocaine cues
- Transforming growth factor-β1 regulates CDK5 activity in primary sensory neurons
- Perinatal abrogation of CDK5 expression in brain results in neuronal migration defects
- CDK5 , the multifunctional surveyor
- Suppression of mutant Huntingtin aggregate formation by CDK5 /p35 through the effect on microtubule stability
- Relative resistance of CDK5 -phosphorylated CRMP2 to dephosphorylation
- Nestin as a regulator of CDK5 in differentiating myoblasts
- Role of CDK5 in the pathogenesis of Alzheimer’s disease
- Brain levels of CDK5 activator p25 are not increased in Alzheimer’s or other neurodegenerative diseases with neurofibrillary tangles
- The protein SET binds the neuronal CDK5 activator p35 nck5a and modulates CDK5 /p35 nck5a activity
- Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (CDK5 /p20) using mass spectrometry
- Potent inhibitors of CDK5 derived from roscovitine: Synthesis, biological evaluation and molecular modelling
- CDK5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain
- Cyclin-dependent kinase 5 (CDK5 ) and neuronal cell death
- Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (CDK5 )
- A novel, extraneuronal role for cyclin-dependent protein kinase 5 (CDK5 ): modulation of cAMP-induced apoptosis in rat leukemia cells
- Cyclin E is expressed in neurons and forms complexes with CDK5
- Increased CDK5 /p35 activity in the dentate gyrus mediates depressive-like behaviour in rats
- Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by CDK5 affects centrosome function
- Synaptic NMDA receptor stimulation activates PP1 by inhibiting its phosphorylation by CDK5
- ROCK inhibition prevents tau hyperphosphorylation and p25/CDK5 increase after global cerebral ischemia.
- Coexpression of human CDK5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice
- AKT and CDK5 /p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro
- Cyclin I-CDK5 governs survival in post-mitotic cells
- Evidence for CDK5 as a major activity phosphorylating tau protein in porcine brain extract
- Alternative roles for CDK5 in learning and synaptic plasticity
- Pctaire1 interacts with p35 and is a novel substrate for CDK5 /p35
- S-nitrosylation of CDK5 : potential implications in amyloid-β-related neurotoxicity in Alzheimer disease
- Synaptic localization of p39, a neuronal activator of CDK5
- … -induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, CDK5 and adenylate cyclase activity
- Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1’s attenuation of β-amyloid peptide25–35-induced tau hyperphosphorylation in cortical neurons
- Nestin protects mouse podocytes against high glucose‐induced apoptosis by a CDK5 ‐dependent mechanism
- Phosphorylation of the tubulin‐binding protein, stathmin, by CDK5 and MAP kinases in the brain
- p10, the N-terminal domain of p35, protects against CDK5 /p25-induced neurotoxicity
- CDK5 regulates cell adhesion and migration in corneal epithelial cells
- Twice switched at birth: cell cycle-independent roles of the “neuron-specific” cyclin-dependent kinase 5 (CDK5 ) in non-neuronal cells
- CDK5 /p25nck5a interaction with synaptic proteins in bovine brain
- Impaired neurogenesis and neurite outgrowth in an HIV-gp120 transgenic model is reversed by exercise via BDNF production and CDK5 regulation
- Charcot–Marie–Tooth causing HSPB1 mutations increase CDK5 -mediated phosphorylation of neurofilaments
- The role of CDK5 in cognition and neuropsychiatric and neurological pathology
- CDK5 as a drug target for the treatment of Alzheimer’s disease
- Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistin
- … binding and clustering of human Tau-4R and Tau-P301L proteins isolated from yeast deficient in orthologues of glycogen synthase kinase-3β or CDK5
- CDK5 : a new player at synapses
- Molecular characterization of a neuronal‐specific protein that stimulates the activity of CDK5
- Expression of CDK5 , p35, and CDK5 ‐associated kinase activity in the developing rat lens
- Nucleocytoplasmic CDK5 is involved in neuronal cell cycle and death in post-mitotic neurons
- p35 is required for CDK5 activation in cellular senescence
- Chronic mild stress in mice promotes cognitive impairment and CDK5 -dependent tau hyperphosphorylation
- CDK5 –p39 is a labile complex with the similar substrate specificity to CDK5 –p35
- CDK5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase
- Modulation of the JNK and p38 pathways by CDK5 protein kinase in a transgenic mouse model of Alzheimer’s disease
- CDK5 /p35 phosphorylates lemur tyrosine kinase‐2 to regulate protein phosphatase‐1C phosphorylation and activity
- Precursor of CDK5 activator, the 23 kDa subunit of tau protein kinase II: its sequence and developmental change in brain
- Synthesis and structure-activity relationship of 4-(1, 3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (CDK5 )/p25 inhibitors
- CDK5 and Trio modulate endocrine cell exocytosis
- Structure–activity relationships of 3, 4-dihydro-1H-quinazolin-2-one derivatives as potential CDK5 inhibitors
- Microtubule-stimulated phosphorylation of tau at Ser202 and Thr205 by CDK5 decreases its microtubule nucleation activity
- CDK5 phosphorylates PLD2 to mediate EGF-dependent insulin secretion
- PKCδ regulates cortical radial migration by stabilizing the CDK5 activator p35
- Different mechanisms of CDK5 and CDK2 activation as revealed by CDK5 /p25 and CDK2/cyclin A dynamics
- Striatal dysregulation of CDK5 alters locomotor responses to cocaine, motor learning, and dendritic morphology
- CDK5 phosphorylates non-genotoxically overexpressed p53 following inhibition of PP2A to induce cell cycle arrest/apoptosis and inhibits tumor progression
- CDK5 -dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP
- Late recruitment of synapsin to nascent synapses is regulated by CDK5
- Neurodegeneration and neuroinflammation in CDK5 /p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration
- Peptides derived from CDK5 activator p35, specifically inhibit deregulated activity of CDK5
- Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes
- CDK5 -dependent phosphorylation of the Rho family GTPase TC10α regulates insulin-stimulated GLUT4 translocation
- CDK5 and the mystery of synaptic vesicle endocytosis
- Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by CDK5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells …
- High NaCl–induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its …
- Local expression of mIgf-1 modulates ubiquitin, caspase and CDK5 expression in skeletal muscle of an ALS mouse model
- Neuron-specific CDK5 kinase is responsible for mitosis-independent phosphorylation of c-Src at Ser75 in human Y79 retinoblastoma cells
- Cooperative roles of c-Abl and CDK5 in regulation of p53 in response to oxidative stress
- Downregulation of neuronal CDK5 /p35 in opioid addicts and opiate-treated rats: relation to neurofilament phosphorylation
- CDK5 and the non-catalytic arrest of the neuronal cell cycle
- CDK5 targets active Src for ubiquitin-dependent degradation by phosphorylating Src (S75)
- CDK5 -mediated phosphorylation of δ-catenin regulates its localization and GluR2-mediated synaptic activity
- Potential neuroprotective flavonoid-based inhibitors of CDK5 /p25 from Rhus parviflora
- Microtubule association of the neuronal p35 activator of CDK5
- Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (CDK5 )
- CDK5 regulates cell-matrix and cell-cell adhesion in lens epithelial cells
- Involvement of cAMP in nerve growth factor-triggered p35/CDK5 activation and differentiation in PC12 cells
- Identification of ribosomal protein L34 as a novel CDK5 inhibitor
- Identification of a common protein association region in the neuronal CDK5 activator
- GTP-dependent secretion from neutrophils is regulated by CDK5
- Neuronal Cdc2-like protein kinase (CDK5 /p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2
- The cyclin-dependent kinases cdk2 and CDK5 act by a random, anticooperative kinetic mechanism
- Calpain inhibitor inhibits p35-p25-CDK5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats
- Molecular roles of CDK5 in pain signaling
- Bortezomib action in multiple myeloma: microRNA-mediated synergy (and miR-27a/CDK5 driven sensitivity)?
- CDK5 and munc-18/p67 co-localization in early stage neurofibrillary tangles-bearing neurons in Alzheimer type dementia brains
- Intracellular localization of cyclin-dependent kinase 5 (CDK5 ) in mouse neuron: CDK5 is located in both nucleus and cytoplasm
- Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (CDK5 ) activator p35 in cultured …
- Co-purification and localization of Munc18-1 (p67) and CDK5 with neuronal cytoskeletal proteins
- The presence of active CDK5 associated with p35 in astrocytes and its important role in process elongation of scratched astrocyte
- CDK5 mediates vimentin ser56 phosphorylation during GTP‐induced secretion by neutrophils
- Protein-protein interactions in CDK5 regulation and function
- TGF-β1 sensitizes TRPV1 through CDK5 signaling in odontoblast-like cells
- EGFR/MEK/ERK/CDK5 -dependent integrin-independent FAK phosphorylated on serine 732 contributes to microtubule depolymerization and mitosis in tumor …
- CDK5 regulates activation and localization of Src during corneal epithelial wound closure
- Neuroprotective effect of TNFα against the β-amyloid neurotoxicity mediated by CDK5 kinase
- The structural perspective on CDK5
- Evidence of calpain/CDK5 pathway inhibition by lithium in 3-nitropropionic acid toxicity in vivo and in vitro
- CDK5 /p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription
- CDK5 /p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells
- Dopamine D1 receptor activation induces tau phosphorylation via CDK5 and GSK3 signaling pathways
- Soluble alpha-APP (sAPPalpha) regulates CDK5 expression and activity in neurons
- Retinoic acid induces apoptosis of prostate cancer DU145 cells through CDK5 overactivation
- New approaches to the discovery of CDK5 inhibitors
- The CDK5 kinase downregulates ATP-gated ionotropic P2X3 receptor function via serine phosphorylation
- First BRET‐based screening assay performed in budding yeast leads to the discovery of CDK5 /p25 interaction inhibitors
- Forebrain-specific deletion of CDK5 in pyramidal neurons results in mania-like behavior and cognitive impairment
- Cyclin-dependent kinase 5 (CDK5 ) regulates the function of CLOCK protein by direct phosphorylation
- CDK5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock
- At the fulcrum in health and disease: CDK5 and the balancing acts of neuronal structure and physiology
- Effects of natural flavones and flavonols on the kinase activity of CDK5
- Identification of novel substrates for CDK5 and new targets for CDK5 inhibitors using high‐density protein microarrays
- Silencing of CDK5 as potential therapy for Alzheimer’s disease
- Intrathecal administration of roscovitine inhibits CDK5 activity and attenuates formalin-induced nociceptive response in rats
- Purification of a 15-kDa cdk4-and CDK5 -binding protein.
- Cdk7 functions as a CDK5 activating kinase in brain
- CDK5 phosphorylation of FAK regulates centrosome-associated microtubules and neuronal migration
- Role of caspases, calpain and CDK5 in ammonia-induced cell death in developing brain cells
- Cyclin-dependent kinase 5 (CDK5 ): a potential therapeutic target for the treatment of neurodegenerative diseases and diabetes mellitus
- The notch signaling inhibitor dapt down‐regulates CDK5 activity and modulates the distribution of neuronal cytoskeletal proteins
- The involvement of CDK5 activator p35 in social isolation-triggered onset of early Alzheimer’s disease-related cognitive deficit in the transgenic mice
- Potentiation of tau aggregation by CDK5 and GSK3β
- Calpastatin, an endogenous calpain‐inhibitor protein, regulates the cleavage of the CDK5 activator p35 to p25
- Okadaic acid-stimulated degradation of p35, an activator of CDK5 , by proteasome in cultured neurons
- CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton
- CDK5 in neuroskeletal dynamics
- Novel members of the cdc2-related kinase family in Drosophila: cdk4/6, CDK5 , PFTAIRE, and PITSLRE kinase.
- Synaptic deficits are rescued in the p25/CDK5 model of neurodegeneration by the reduction of β-secretase (BACE1)
- Regulation of kalirin by CDK5
- Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population
- Up‐regulation of CDK5 /p35 by oxidative stress in human neuroblastoma IMR‐32 cells
- Calmodulin binding and CDK5 phosphorylation of p35 regulate its effect on microtubules
- The levels of CDK5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis
- β2-Syntrophin is a CDK5 substrate that restrains the motility of insulin secretory granules
- Changes in the expression of novel CDK5 activator messenger RNA (p39nck5ai mRNA) during rat brain development
- X-ray irradiation promotes apoptosis of hippocampal neurons through up-regulation of CDK5 and p25
- CDK5 : mediator of neuronal development, death and the response to DNA damage
- Targeting p35/CDK5 signalling via CIP-peptide promotes angiogenesis in hypoxia
- Activation of latent cyclin‐dependent kinase 5 (CDK5 )–p35 complexes by membrane dissociation
- Design and synthesis of quinolin-2 (1H)-one derivatives as potent CDK5 inhibitors
- Cerebral ischemia, cell cycle elements and CDK5
- Characterization of a novel human CDK5 splicing variant that inhibits Wnt/β-catenin signaling
- Cell Cycle Regulatory Protein 5 (CDK5 ) is a Novel Downstream Target of ERK in Carboplatin Induced Death of Breast Cancer Cells (Supplementary Data)
- Structure–activity relationship study of 2, 4-diaminothiazoles as CDK5 /p25 kinase inhibitors
- Novel purine-based fluoroaryl-1, 2, 3-triazoles as neuroprotecting agents: synthesis, neuronal cell culture investigations, and CDK5 docking studies
- Neurabin-I is phosphorylated by CDK5 : implications for neuronal morphogenesis and cortical migration
- Resveratrol inhibits CDK5 activity through regulation of p35 expression
- p35, the non-cyclin activator of CDK5 , protects podocytes against apoptosis in vitro and in vivo
- Cyclin-dependent kinase 5 (CDK5 ) associated with Lewy bodies in diffuse Lewy body disease
- Reelin signaling and CDK5 in the control of neuronal positioning
- Increase of CDK5 is related to neurofibrillary pathology in progressive supranuclear palsy
- Apoptosis-associated tyrosine kinase is a CDK5 activator p35 binding protein
- Major CDK5 ‐dependent phosphorylation sites of amphiphysin 1 are implicated in the regulation of the membrane binding and endocytosis
- Outer Dense Fibers Serve as a Functional Target for CDK5 · p35 in the Developing Sperm Tail
- Estrogen-dependent facilitation on spinal reflex potentiation involves the CDK5 /ERK1/2/NR2B cascade in anesthetized rats
- Mutational and expression analysis of the reelin pathway components CDK5 and doublecortin in gangliogliomas
- Porcine brain neurofilament‐H tail domain kinase: Its identification as CDK5 /p26 complex and comparison with cdc2/cyclin B kinase
- Deregulation of CDK5 in Hippocampal sclerosis
- Increased expression of CDK5 /p25 in N2a cells leads to hyperphosphorylation and impaired axonal transport of neurofilament proteins
- Cortical development: CDK5 gets into sticky situations
- Changes in the activity of cdk2 and CDK5 accompany differentiation of rat primary oligodendrocytes
- Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5 /p25
- Cyclin-dependent kinase-5 (CDK5 ) and amyotrophic lateral sclerosis
- CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells
- Drosophila lacking the CDK5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan
- An in silico approach for the discovery of CDK5 /p25 interaction inhibitors
- Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5
- Combined inhibition of CDK5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells
- Role of CDK5 in neuroprotection from serum deprivation by μ-opioid receptor agonist
- Role of p35/CDK5 in preplate splitting in the developing cerebral cortex
- CDK5 inhibitory peptide (CIP) inhibits CDK5 /p25 activity induced by high glucose in pancreatic beta cells and recovers insulin secretion from p25 damage
- Age-dependent pharmacokinetics and effect of roscovitine on CDK5 and Erk1/2 in the rat brain
- Induction of CDK5 activity in rat skeletal muscle after nerve injury
- Clausine Z, a new carbazole alkaloid from Clausena excavata with inhibitory activity on CDK5 .
- CDK5 : a novel role in learning and memory
- Crosstalk between CDK5 and MEK–ERK signalling upon opioid receptor stimulation leads to upregulation of activator p25 and MEK1 inhibition in rat brain
- Phosphorylation of AATYK1 by CDK5 suppresses its tyrosine phosphorylation
- CDK5 is a novel regulatory protein in PPARγ ligand-induced antiproliferation
- A sequel to the tale of p25/CDK5 in neurodegeneration
- CDK5 modulates β‐and δ‐catenin/Pin1 interactions in neuronal cells
- CDK5 phosphorylates dopamine D2 receptor and attenuates downstream signaling
- Neuroadaptations of CDK5 in cholinergic interneurons of the nucleus accumbens and prefrontal cortex of inbred alcohol‐preferring rats following voluntary alcohol …
- Kinetic studies of CDK5 /p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors
- Neuroadaptations of total levels of adenylate cyclase, protein kinase A, tyrosine hydroxylase, CDK5 and neurofilaments in the nucleus accumbens and ventral …
- Studying synergism of methyl linked cyclohexyl thiophenes with triazole: Synthesis and their CDK5 /p25 inhibition activity
- Cortical interneurons require p35/CDK5 for their migration and laminar organization
- Transient Enhanced Expression of CDK5 Activator p25 after Acute and Chronic d‐Amphetamine Administration
- CDK5 regulates cell–cell and cell–matrix adhesion in human keratinocytes
- Neuronal Cdc2-like kinases: neuron-specific forms of CDK5
- Inhibition of calpain-regulated p35/CDK5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate
- CDK5 interacts with Hif-1α in neurons: A new hypoxic signalling mechanism?
- p39, the primary activator for cyclin-dependent kinase 5 (CDK5 ) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair
- Involvement of septal CDK5 in the emergence of excessive anxiety induced by stress
- ODF1 phosphorylation by CDK5 /p35 enhances ODF1-OIP1 interaction
- α‐Chimaerin exists in a functional complex with the CDK5 kinase in brain
- CDK5 /p35 expression in the mouse ovary
- Absence of the CDK5 activator p35 causes adult-onset neurodegeneration in the central brain of Drosophila
- Inhibition of the CDK5 /MEF2 pathway is involved in the antiapoptotic properties of calpain inhibitors in cerebellar neurons
- 3-Nitropropionic acid activates calpain/CDK5 pathway in rat striatum
- DNA binding protein dbpA binds CDK5 and inhibits its activity
- Obesity-linked phosphorylation of PPARγ by CDK5 is a direct target of the anti-diabetic PPARγ ligands
- Dopamine signaling negatively regulates striatal phosphorylation of CDK5 at tyrosine 15 in mice
- The primary microcephaly 3 (MCPH3) interacting protein, p35 and its catalytic subunit, CDK5 , are centrosomal proteins
- A catch-and-release strategy for the combinatorial synthesis of 4-acylamino-1, 3-thiazoles as potential CDK5 inhibitors
- The kinase activity of EphA4 mediates homeostatic scaling-down of synaptic strength via activation of CDK5
- Phosphoproteome and transcriptome analysis of the neuronal response to a CDK5 inhibitor
- The molecular mystery of neuronal migration: FAK and CDK5
- AATYK1A phosphorylation by CDK5 regulates the recycling endosome pathway
- CDK5 in the adult non-demented brain
- p53, Apaf-1, caspase-3, and-9 are dispensable for CDK5 activation during cell death
- A CDK5 inhibitor enhances induction of insulin secretion by exendin-4 both in vitro and in vivo
- Association of neurofilament proteins with neuronal CDK5 activator
- Protein kinase CK2 is an inhibitor of the neuronal CDK5 kinase
- Distinct cellular compartment of cyclin-dependent kinase 5 (CDK5 ) and neuron-specific CDK5 activator protein (p35nck5a) in the developing rat cerebellum
- Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (CDK5 ), on the proteolysis of p35
- CDK5 regulates Rap1 activity
- Abnormal expression of CDK5 in focal cortical dysplasia in humans
- Expression of CDK5 and its activators in NT2 cells during neuronal differentiation
- The neuronal p35 activator of CDK5 is a novel F-actin binding and bundling protein
- Investigating the neuroprotective mechanism of action of a CDK5 inhibitor by phosphoproteome analysis
- Glutamate treatment and p25 transfection increase CDK5 mediated tau phosphorylation in SH-SY5Y cells
- The Xenopus laevis homologue to the neuronal cyclin-dependent kinase (CDK5 ) is expressed in embryos by gastrulation
- Evolution of isocortical organization. A tentative scenario including roles of reelin, p35/CDK5 and the subplate zone
- Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated CDK5 conditional knockout mice
- The cyclin‐dependent kinase inhibitor roscovitine inhibits kinase activity, cell proliferation, multicellular development, and CDK5 nuclear translocation in Dictyostelium …
- Early postnatal in vivo gliogenesis from nestin-lineage progenitors requires CDK5
- The role of the p35/CDK5 kinase in cortical development
- CDK5 phosphorylates a component of the HDAC complex and regulates histone acetylation during neuronal cell death
- The complex p25/CDK5 kinase in neurofibrillary degeneration and neuronal death: the missing link to cell cycle
- Peroxiredoxin-2 links CDK5 to neurodegeneration
- Hyperphosphorylation of tau and neurofilaments and activation of CDK5 and ERK1/2 in PTEN-deficient cerebella
- Developmental Alteration of the Expression and Kinase Activity of Cyclin‐Dependent Kinase 5 (CDK5 )/p35nck5a in the Rat Retina
- Structural basis for the different stability and activity between the CDK5 complexes with p35 and p39 activators
- Cyclin dependent kinase 5 (CDK5 )
- CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5
- Regulation of membrane association and kinase activity of CDK5 –p35 by phosphorylation of p35
- PKC {zeta} Regulates CDK5 /P25 signaling during myogenesis
- CDK5 inhibits anterograde axonal transport of neurofilaments but not that of tau by inhibition of mitogen-activated protein kinase activity
- Role of CDK5 and Tau phosphorylation in heterotrimeric G protein–mediated retinal growth cone collapse
- Activity and regulation of p35/CDK5 kinase complex
- Interplay between the p53 tumor suppressor protein family and CDK5
- ik3-2, a relative to ik3-1/cables, is associated with cdk3, CDK5 , and c-abl
- Aberrant activation of CDK5 is involved in the pathogenesis of OPIDN
- CDK5 selectively affects the migration of different populations of neurons in the developing spinal cord
- Repeated acetyl‐l‐carnitine administration increases phospho‐Thr34 DARPP‐32 levels and antagonizes cocaine‐induced increase in CDK5 and phospho‐Thr75 …
- Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein-C53
- Cloning and characterization of the Drosophila melanogaster CDK5 homolog
- Alterations in cyclin-dependent protein kinase 5 (CDK5 ) protein levels, activity and immunocytochemistry in canine motor neuron disease
- Ginsenoside Rb1 attenuates beta-amyloid peptide (25-35)-induced hyperphosphorylation of tau protein through CDK5 signal pathway
- ERM proteins and CDK5 in cellular senescence
- Association between plasma biomarkers, CDK5 polymorphism and the risk of Alzheimer’s disease
- Immunohistochemical localization of CDK5 activator p39 in the rat brain
- CDK5 kinase regulates the association between adaptor protein Bem1 and GEF Cdc24 in the fungus Ustilago maydis
- Cyclin dependent kinase 5 (CDK5 ) mediated inhibition of the MAP kinase pathway results in CREB down regulation and apoptosis in PC12 cells
- Zebrafish Rohon-Beard neuron development: CDK5 in the midst
- Fuzhisan, a Chinese Herbal Medicine, Inhibits Beta-Amyloid-Induced Neurotoxicity and Tau Phosphorylation Through Calpain/CDK5 Pathway in Cultured Cortical …
- Identification and structure characterization of a Cdk inhibitory peptide derived from neuronal-specific CDK5 activator
- Distinct functions of CDK5 (Y15) phosphorylation and CDK5 activity in stress fiber formation and organization
- A scintillation proximity assay for studying inhibitors of human tau protein kinase II/CDK5 using a 96-well format
- CDK5 phosphorylates eNOS at Ser‐113 and regulates NO production
- CDK5 : Links to DNA damage
- Potent anti-diabetic actions of a novel non-agonist PPARγ ligand that blocks CDK5 -mediated phosphorylation
- The CDK5 homologue, Crp, regulates endocytosis and secretion in Dictyostelium and is necessary for optimum growth and differentiation
- Design and synthesis of 6-oxo-1, 6-dihydropyridines as CDK5 inhibitors
- CDK5 : an emerging kinase in pain signaling
- Increased accumbens CDK5 expression in rats after short-access to self-administered cocaine, but not after long-access sessions
- The CDK5 inhibitor olomoucine promotes corneal debridement wound closure in vivo
- Role of the pyrrolidine ring of proline in determining the substrate specificity of cdc2 kinase or CDK5
- p25/CDK5 is partially involved in neuronal injury induced by radiofrequency electromagnetic field exposure
- Involvement of cyclin d1‐CDK5 overexpression and mcm3 cleavage in bax‐associated spontaneous apoptosis and differentiation in an a253 human head and neck …
- Drosophila CDK5 is needed for locomotive behavior and NMJ elaboration, but seems dispensable for synaptic transmission
- Kinetic mechanistic studies of CDK5 /p25-catalyzed H1P phosphorylation: metal effect and solvent kinetic isotope effect
- The CDK5 /p35 kinases modulate leptin-induced STAT3 signaling
- Neuronal Differentiation and Patterning inXenopus: The Role of CDK5 and a Novel Activator Xp35. 2
- CDK5 is a dynamo at the synapse
- CDK5 : A regulator of epithelial cell adhesion and migration
- The CDK5 activator, p39, binds specifically to myosin essential light chain
- Prenatal cocaine and morphine alter brain cyclin-dependent kinase 5 (CDK5 ) activity in rat pups
- CDK5 : the” pathfinder” for new born neurons in adult hippocampus?
- Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein
- Identifying novel substrates for mouse CDK5 kinase using the yeast Saccharomyces cerevisiae
- CDK5 , CRMP2 and NR2B in spinal dorsal horn and dorsal root ganglion have different role in pain signaling between neuropathic pain model and inflammatory pain …
- CDK5 variant 1 (CDK5 -v1), but not full-length CDK5 , is a centrosomal protein
- Synthesis and evaluation of new potent inhibitors of CK1 and CDK5 , two kinases involved in Alzheimer’s disease
- Synergistic gene expressions of cyclin E, cdk2, CDK5 and E2F-1 during the prolactin-induced G1/S transition in rat Nb2 pre-T lymphoma cells.
- CDK5 in the centriolar appendages mediates cenexin1 localization and primary cilia formation
- CDK5 -induced neuronal cell death: The activation of the conventional Rb-E2F G1 pathway in post-mitotic neurons
- Localization of CDK5 in the midbody and increased aneuploidy in CDK5 -/- cells
- Comparison of munc-18 and CDK5 expression in the nervous system during mouse embryogenesis
- Role of a CDK5 -associated protein, p35, in herpes simplex virus type 1 replication in vivo
- CDK5 : A new lead to survival
- CDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylation
- When good CDK5 turns bad
- Increased immunoreactivity of CDK5 activators in hippocampal sclerosis
- Identification of non-muscle myosin heavy chain as a substrate for CDK5 and tool for drug screening
- Development of an assay to screen for inhibitors of tau phosphorylation by CDK5
- CDK5 expression and association with p35nck5a in early stages of rat cerebellum neurogenesis; tyrosine dephosphorylation and activation in post-mitotic neurons
- A cdc2-like kinase distinct from CDK5 is associated with neurofilaments
- Novel aspects in structure–activity relationships of profiled 1-aza-9-oxafluorenes as inhibitors of Alzheimer’s disease-relevant kinases cdk1, CDK5 and gsk3β
- Novel insights into the beneficial and detrimental actions of CDK5
- Direct and indirect roles of CDK5 as an upstream regulator in the JNK cascade: relevance to neurotoxic insults in Alzheimer’s disease
- Structural insights into CDK5 activation by a neuronal CDK5 activator
- The neuronal cyclin-dependent kinase 5 activator p35Nck5a and CDK5 activity in monocytic cells
- Mechanism of CDK5 activation revealed by steered molecular dynamics simulations and energy calculations
- Decreasing levels of the CDK5 activators, p25 and p35, reduces excitotoxicity in striatal neurons
- Ras target protein canoe is a substrate for Cdc2 and CDK5 kinases
- Identification of p10 as a neurotoxic product generated from the proteolytic cleavage of the neuronal CDK5 activator
- A novel mechanism of non-Aβ component of Alzheimer’s disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (CDK5 )
- Overexpression of CDK5 or non-phosphorylatable retinoblastoma protein protects septal neurons from oxygen–glucose deprivation
- CDK5 at the junction
- The CDK5 inhibitor roscovitine strongly inhibits glucose uptake in 3T3‐L1 adipocytes without altering GLUT4 translocation from internal pools to the cell surface
- Molecular cloning and characterisation of a mouse gene encoding an isoform of the neuronal cyclin-dependent kinase 5 (CDK5 ) activator
- Rho/ROCK and CDK5 effects on phosphorylation of a β-thymosin repeat protein in Hermissenda
- A dinoflagellate CDK5 ‐like cyclin‐dependent kinase
- Differential regulation of CDK5 and c-Fos expression by morphine in the brain of Lewis and Fischer 344 rat strains
- Production of Mouse ES Cells Homozygous for CDK5 -Phosphorylated Site Mutation in c-src Alleles
- Binding mechanism of inhibitors to CDK5 /p25 complex: free energy calculation and ranking aggregation analysis
- Ontogeny of abnormal brain development in CDK5 (-/-) mice
- Differential regulation of the CDK5 ‐dependent phosphorylation sites of inhibitor‐1 and DARPP‐32 by depolarization
- Effect of CDK5 antagonist on L-dopa-induced dyskinesias in a rat model of Parkinson’s disease
- Cyclin-Dependent Kinase 5 (CDK5 ) modulates signal transduction pathways regulating neuronal survival
- Changes of CDK5 , p35 and p53 gene expression levels in arsenic-induced neural cell apoptosis
- Involvement of CDK5 in synaptic plasticity, and learning and memory
- Therapeutic potential of CDK5 inhibitors to promote corneal epithelial wound healing
- No association of polymorphisms in the CDK5 , NDEL1, and LIS1 with autism in Chinese Han population
- No association of CDK5 genetic variants with Alzheimer’s disease risk
- Hippocampal mossy fiber sprouting and CDK5 /p35 expressions in the pentylenetetrazole kindling rat model
- Regulation and function of CDK5 in the nucleus
- The kinase activity of CDK5 and its regulation
- Molecular dynamic simulations give insight into the mechanism of binding between 2-aminothiazole inhibitors and CDK5
- CDK5 , a journey from brain to pain: lessons from gene targeting
- Expression of CyclinE and CDK5 in lung cancer
- CDK5 checks p27kip1 in neuronal migration
- CDK5 inhibition diminishes pancreatic cancer tumorigenesis and metastasis
- Cloning and Spatio-Temporal Expression of Porcine CDK5 and CDK5 R1(p35) Genes
- Cell cycle-related genes p57kip2, CDK5 and Spin in the pathogenesis of neural tube defects
- Involvement of CDK5 /p35 and tau protein in the hippocampal mossy fiber sprouting in the PTZ kindling model
- Addressing the complex etiology of Alzheimer’s disease: the role of p25/CDK5
- 1001 CDK5 is Involved in Oxaliplatin Response and Resistance Acquisition Through Regulation of STAT3 Transcription Factor
- Expression and activity of CDK5 /p35 in a rat model of trigeminal neuropathic pain
- p35 and p25 expressions and CDK5 kinase activity in primary cultured rat hippocampal neurons with X-ray exposure
- Association of rs2069459 in the CDK5 gene with dyslexia in a German cohort
- Tyrosine hydroxylase expression and CDK5 kinase activity in ataxic cerebellum
- CRMP Family Protein: Novel Targets for CDK5 That Regulates Axon Guidance, Synapse Maturation, and Cell Migration
- Pro-apoptotic signaling pathway by CDK5 and MEKK1
- Protein Kinase Cζ Regulates CDK5 /p25 Signaling during Myogenesis
- Developmental mRNA Expression of CDK5 and its Putative Regulators, p67 and p35, in Rat Brain
- CDK5 is present in sea urchin and starfish eggs and embryos and can interact with p35, cyclin E and cyclin B3
- The role of CDK5 in non‐neuronal tissues
- A Novel Role for Lymphocyte Expression of the Cyclin-Dependent Kinase 5 (CDK5 ) in the Generation of Allogeneic T Cell Responses After BMT
- Cyclin dependent kinase 5 (CDK5 ): a possible link between neuropathologies and diabetes
- Regulation of the NAD+-dependent deacetylase SIRT2 by CDK5
- Loss of CDK5 sensitizes ovarian cancer cells to paclitaxel by enhancing intracellular retention
- Neuronal Motility and Structure: CDK5 Pathways
- CDK5 /p35 activity is essential for eye growth and retinal lamination in zebrafish
- Role of CDK5 activators in psychiatric diseases, learning and memory
- Cyclin-Dependent Kinase 5 (CDK5 ): Linking Synaptic Plasticity and Neurodegeneration
- Cyclin-Dependent Kinase 5 (CDK5 ): Preparation and Measurement of Kinase Activity
- For new neurons in an old brain, CDK5 shows the way
- Alzheimer’s disease: No effect of the CDK5 gene on CSF biomarkers, neuropathology or disease risk
- Identification of a human cDNA encoding a kinase-defective CDK5 isoform
- CDK5 keeps memory on Trk
- CDK5 in presynapses
- CDK5 as a drug target for Alzheimer’s disease
- Identification of Pctaire1 as a p35-interacting protein and a novel substrate for CDK5
- An Unusual Member of the Cdk Family: CDK5 .
- CDK5 and Mekk1 mediate a Pro-Apoptotic Signaling Response to Endoplasmic Reticulum Stress in a Drosophila Model of Autosomal Dominant Retinitis …
- Design and Synthesis of Benzimidazoles as CDK5 Inhibitors and Progress Toward the Total Synthesis of Tubulysin D
- Modulation of transient receptor potential cation channel, subfamily A, member 1 (TRPA1) activity by CDK5
- The study of the role of cyclin-dependent kinase 5 (CDK5 ) during cell death
- CDK5 activity is required for BDNF-stimulated neuronal survival and synaptic plasticity
- S-nitrosylation of CDK5 regulates its kinase activity and dendrite growth during neuronal development
- Identification of TrkB as a p35 interacting protein and a CDK5 substrate
- Unraveling CDK5 -mediated signaling in Alzheimer’s disease pathogenesis
- Src Binds Directly to CDK5 Without Requirement for CDK5 Activity or Phosphorylation
- ANKRA2 interacts with p35 and is a substrate for CDK5 /p35
- Understanding the role of CDK5 in activity-induced gene expression during dendrite development
- CDK5 Regulates Corneal Epithelial Cell Adhesion and Migration in vitro
- A peptide derived from cyclinâ dependent kinase activator (p35) specifically inhibits CDK5 activity and phosphorylation of tau protein in transfected cells
- CDK5 Activity Regulates Myosin Phosphorylation in Lens Epithelial Cells
- CDK5 Is Essential for Recruitment of Active Src to Focal Adhesions
- Phosphorylating Activity of the Alzheimer’s Disease-associated Kinase CDK5 is Selectively Inhibited ill vitro
- Involvement of CDK5 /p35 in EphB2-dependent dendritic spine development
- CDK5 is a membrane-associated protein kinase whose mislocalization induces neuronal cell death
- CDK5 : A Contributor to the Insulin Phenotype of Transdifferentiated β Cells
- Are chemical inhibitors an effective way to study the role of Cyclin Dependent Kinase 5 (CDK5 ) in neuronal and pancreatic development? Comparative kinase assays …
- CDK5 Specifically Affects Rho Activation Required for Myosin-Dependent Contraction and Stress Fiber Maintenance in Spreading Lens Epithelial Cells
- Functional characterization of CDK5 -mediated phosphorylation of endophilin B1 in macroautophagy in models of parkinson’s disease
- … PARP-1, PARP-2 and CDK5 proteins and chromatin implication; Facteurs modulant la radiosensibilite: Role des proteines PARP-1, PARP-2 et CDK5 et implication de …
- The role of CDK5 in endophilinB1-mediated regulation of NGF/TrkA trafficking
- Expression and distribution of cyclin-dependent kinase 5 (CDK5 ) in the developing rat brain
- Phosphorylation of TonEBP/OREBP by cyclin dependent kinase 5 (CDK5 ) mediates its NaCl‐induced nuclear translocation
- CDK5 , a cdk which is required for myogenesis, shows marked changes in sub-cellular distribution during early myogenesis and at the G1-S transition in fibroblasts.
- The role of cyclin-dependent kinase 5 (CDK5 ) in Neurodegeneration
- Expression and activity of CDK5 /p39 during rats Vc development
- Inhibition of CDK5 activity alters localization of cSRC and promotes corneal wound healing in vitro
- Functional investigation of the neuronal CDK5 activator p35 in the regulation of actin dynamics
- Mice overexpressing dominant negative CDK5 in the pancreatic beta-cells show the phenotype of type 1 diabetes mellitus
- The role of CDK5 in EphB-mediated synaptogenesis
- The CDK5 Activating Protein, p39, Interacts With Nonmuscle Myosin Light Chain
- CDK5 modulates the cell cycle, apoptosis and paclitaxel sensitivity in human ovarian cancer cells with wild-type p53 function
- CDK5 Phosphorylated at Tyrosine-15 Co-Localizes With Early Focal Adhesions in Cultured Human Corneal Limbal Epithelial Cells
- Dynamics of human CDK2 and CDK5 studied by computer simulations
- CDK5 expression of spinal motor neuron in immune-mediated injury
- CDK5 : new insights into its biological function in human brain microvascular endothelial cells
- Cell-Cell Junctions in a CDK5 -Deficient Corneal Epithelial Cell Line
- Inhibition of CDK5 Attenuates Experimental Autoimmune Uveitis
- Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.
- Function and regulation of the neuronal CDK5 /p35 kinase in the control of protein translation
- Molecular characterization and structural determination of a CDK5 inhibitory peptide derived from neuronal CDK5 activator
- Using Chemical Inhibitors to Study the Role of the Cyclin Dependent Kinase 5 (CDK5 ) Protein in the Nerve Growth Factor Induced Neuronal Differentiation of PC12 …
- The differential expression of P57kip2 and CDK5 in retinoic acid-induced neural tube defects
- The expression and localization of CDK5 /p35 kinase in human malignant glioma cells.
- Alteration in Neuronal Architecture Resulting from the Chemical Inhibition of CDK5 during Neuronal Differentiation
- Identification and characterization of a common protein association region in the neuronal CDK5 activator
- Cyclin Dependent Kinase 5 (CDK5 ): the possible connection in insulin‐related neurodegenerative diseases
- Baculovirus co-expression and purification of CDK5 and p35nck5a
- Interaction Between the CDK5 Activating Proteins, p39 and p35, and an Alternatively Spliced Zinc-Finger Protein in Lens
- The CDK5 /p35 Pathway
- Role Of Calpains And CDK5 In XOR Activation In Pulmonary Microvascular Endothelial Cells Exposed To Hypoxia
- Radiosensitivity modulating factors: Role of PARP-1, PARP-2 and CDK5 proteins and chromatin implication
- The role of CDK5 /p35 and cPLA2/LOX in neuroinflammation and neurodegeneration
- CDK5 inhibition suppresses pancreatic cancer tumorigenesis and metastasis
- Identification and characterization of endophilin B1 as a p35 interacting protein and a CDK5 substrate
- Regulation of synaptic calcium influx by CDK5 phosphorylation
- 419 ALL-TRANS RETINOIC ACID INDUCED CELL CYCLE ARREST AND APOPTOSIS OF DU145 CELLS THROUGH CDK5 ACTIVATION
- Enhanced expression of CDK5 in neuronal differentiation from neurospheres by cell cycle blocker treatment
- Abstract A8: CDK5 modulates ErbB2/3 phosphorylation and prostate cancer cell growth
- The effect of endurance training on gene expression of CDK5 in sensory neurons of male wistar rats with diabetic neuropathy
- CDK5 -Dependent Regulation of Neuronal MEK1
- Effects of lithium on CDK5 and PP2A expressions in chronic aluminum exposure rats
- The CDK5 activator p39 specifically links muskelin to myosin and regulates stress fiber organization and contraction
- Potentiation of GSK-3-catalyzed Alzheimer-like Phosphorylation of Human Tau by CDK5
- Abstract B45: The short-term effects of arsenic on CDK5 -dependent apoptosis of prostate cancer cells
- The CDK5 Activating Protein, p39, Complexes With Muskelin to Regulate Cell Adhesion on Thrombospondin
- The role of flavinoids in the inhibition of CDK5 in neuronal differentiation
- The protein kinase CDK5 : Structural aspects, roles in neurogenesis and involvement in Alzheimer’s pathology
- Insulin disregulation and neurodegeneration: a possible role for CDK5
- Extensive mutational analysis of CDK5 and CDK5 R1 in patients with non-syndromic mental retardation reveals novel variants in CDK5 R1 3′-UTR
- PI3K-dependent motility of prostate cancer cells is mediated through post-transcriptional control of the p35 regulatory subunit of CDK5
- Effect of donepezil hydrochloride on the Calpain Ⅰ-CDK5 pathway expression in the hippocampus of mice with vascular dementia
- CDK5 -mediated phosphorylation and autophagy of Raf kinase inhibitor protein regulate neuronal death in Parkinson’s disease
- CDK5 -MEDIATED HYPERPHOSPHORYLATION CONTRIBUTES TO THE LOSS-OF-SIRT1 FUNCTION DURING THE DEVELOPMENT OF ENDOTHELIAL …
- CDK5 /p35 Regulates Neuronal Migration
- Cyclin-dependent Kinase 5 (CDK5 ) and p35 in Lewy Bodies (LB)
- CDK5 as a Therapeutic Target in Prostate Cancer Metastasis
- Characterization of p35, a neuronal activator of CDK5 , as a novel microtubule-associated protein
- The CDK5 Activating Protein P39 Directly Links Muskelin to Myosin and Stress Fibers
- Effect of heme oxygenase-1 on CDK5 -ATM-P53 signal transduction pathway in rat hippocampal neurons subjected to oxygen-glucose deprivation injury
- CDK5 May Be an Atypical Kinase, but Not in the Way You Think
- CDK5 and Neuregulin-1 Signaling
- Regulation of CDK5 unveiled by its structure with the p25 neuronal activator
- Retinoic Acid Causes CDK5 -Dependent Apoptosis of Cervical Cancer Cell Line
- Memory and Learning: CDK5 tells a tail to remember
- The CDK5 Inhibitor, Roscovitine, Protects Retinal Neurons From Chemical Anoxia, In Vitro, And Excitotoxicity, In Vivo
- Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARg by CDK5
- Monte Carlo and dynamics simulations of CDK5 Kinase inhibitor peptides p5 in aqueous solution
- Intracellular Localization of Cyclin-dependent Kinase 5 (CDK5 ) in the Protozoan Tetrahymena Pyriformis
- CDK5 Kinase Activity, Caspase-3 Expression and Synaptic Structural Plasticity in Infra-limbic Cortex of Rats with Conditioned Fear
- The protective effects of TanIIA on neurotoxicity induced by β-amyloid protein through the CDK5 /P35 pathway in cultured primary neurons
- Phosphorylation of Drp1 by CDK5 (cyclin dependent kinase 5) involves in mitochondrial dynamics regulation
- Abstract A058: t-Darpp is phosphorylated by cdk1 and CDK5 in HER2+ breast cancer cells
- RNAi Screen of the Druggable Genome Identifies Modulators of Proteasome Inhibitor Sensitivity in Myeloma Including CDK5 .
- Phosphorylation of synthetic peptides containing proline homologs by cdc2 kinase or CDK5
- Role of cyclin dependent kinase 5 (CDK5 ) and c‐Abl in high NaCl‐induced nuclear localization of the osmoprotective transcription factor, TonEBP/OREBP
- CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5
- Expression and activity of CDK5 /p39 during rats Vc development.
- Calpain inhibitor inhibits p35-p25-CDK5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats
- Role of CDK5 on ATM phosphorylation in neuronal death induced by DNA damage
- A study of the function of CDK5 in oligodendrocytes differentiation by using conditional knockout strategy
- The Role of CDK5 in the Regulation of Dopamine Neurotransmission, Neuronal Excitability, and Reward-Related Behavior
- Subcellular Translocation of Extracellular Signal-regulated Kinases (ERKs) and Cyclin-dependent Kinase 5 (CDK5 ) in Alzheimer’s Disease and in a Cell Model of …
- CDK5 PHOSPHORYLATION OF MUNC18-1 ENHANCES SYNAPTIC TRANSMISSION
- CDK5 protects huntingtin
- CDK5 and Mitochondrial Cell Death Pathways
- Cell-Penetrating Fragments of the CDK5 Regulatory Subunit Are Protective in Models of Neurodegeneration
- Activity-Dependent Phosphorylation of p70 Ribosomal s6 Kinase (p70S6K) by CDK5 Is Required for Dendritic Spine Maturation
- Functional characterization of CDK5 -mediated phosphorylation of RapGEF2 in cortical development
- CDK5 -dependent Phosphorylation of Mst3 Regulates Radial Migration through Modulating RhoA Activity
- CDK5 in Dendrite and Synapse Development: Emerging Role as a Modulator of Receptor Tyrosine Kinase Signaling
- CDK5 -mediated PI3K/Akt pathway coupling with up-regulation of Bcl-2 confers differentiated neuroblastoma resistance to apoptosis
- The role of thep35/CDK5 kinase in cortical development
- The roles of CDK5 in neuronal development and neurodegeneration
- Increase of CDK5 and p35 during Retinoic Acid-Induced Neuronal Differentiation of SK-N-BE (2) C cells
- Regulation of cyclin-dependent kinase 5 (CDK5 ) in cell death
- Regulators of neurotrophin-mediated Trk signaling: SLAM-associated protein (SAP) and cyclin-dependent kinase 5 (CDK5 )
- Unravelling the complex role of CDK5 in the developing cerebral cortex
- Microtubule-dependent phosphorylation of Tau by CDK5 kinase modulates its activity on microtubule dynamics
- Molecular modeling and SAR studies of CDK5 /p25 selective inhibitors
- P1–416: APP processing and cell cycle reentry signaling pathways are involved in p25/CDK5 –mediated neurodegeneration
- Regulation of the p35/CDK5 kinase in neuronal development and neurodegenerative disease
- Molecular and cellular mechanisms of the cyclin-dependent kinase 5 (CDK5 ) in neocortical migration and layer formation
- CDK5 in neuronal development and potential regulation of kinesins
- Tolfenamic Acid Reduces Total, Phosphorylated Tau and CDK5 Levels via a Transcriptional Pathway: Implications for Dementia and Tauopathies
- Tau Phosphorylation by CDK5 and GSK-3beta: Insights into Physiological Phosphorylation and Pathological Phosphorylation in FTDP-17
- CDK5 Modulation of MAPK Signaling Regulates Neuronal Survival
- MOLECULAR MECHANISMS IN P25/CDK5 -MEDIATED NEUROINFLAMMATION AND SUBSEQUENT NEURODEGENERATION: THERAPEUTIC …
- In vitro modelling of tau phosphorylating kinases: emphasis of CDK5
- Mice lacking phosphatase PP2A subunit PR61/BTδ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β
- P3–277: Severe neurodegeneration is intimately related to inflammation in CDK5 /p25 inducible mice
- From CDK5 to Alzheimer’s disease: future challenges
- Expression studies of the proteolytic p10 fragment of the neuronal CDK5 activator in mammalian cells
- The functional roles of cyclin-dependent kinase 5 (CDK5 ) activators in neuronal and muscle cell differentiation
- p35 and p39 mediated regulation of CDK5 function
- Supplemental Data Article Deregulation of HDAC1 by p25/CDK5 in Neurotoxicity
- Levels of activators of cyclin-dependent protein kinase 5 (CDK5 ) p25 and p35 in Alzheimer’s disease
- Homology Modeling of apo-CDK5 and Insights into Structure-Based Inhibitor Design
- Hyperphosphorylation of tau and neurofilament by constitutive activation of CDK5 in PTEN deficient cerebellum
- Erratum to CDK5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain [Mol. Brain Res. 76 (2000) 229–236]
- The CDK5 -p35 kinase associates with the Golgi apparatus and regulates membrane traffic
- The effects of Calpain-CDK5 -p35 pathway inhibition on rat spinal cord injury, acute pain, and morphine tolerance
- Proteins regulating cyclin dependent kinases Cdk4 and CDK5
- SNAP-25 and CDK5 as exocytotic regulators: Consequences for synaptic function and insulin release
- Identification and characterization of protein kinase CK2 as a novel interacting protein of neuronal CDK5 kinase and its functional role in microtubule dynamics
- The Regulation and Function of CDK5 in Cellular Senescence and Tumorigenesis
- more severe than those of Reeler (5), Mdab1 (19), CDK5 (20), P35 (21), and Pafah1b1 (22) mutants, which suggests that Lhx5 may control a different pathway …
- P25/CDK5 Inhibitors for Alzheimer’s Disease Therapeutics
- Protein Conformational Plasticity: the “off‐on” Switching Movement in CDK5
- Physiological and pathological phosphorylation of tau by CDK5
- CDK5 activity in the brain–multiple paths of regulation
- The role of CDK5 in Alzheimer’s disease
- CDK5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity
- An ERK/CDK5 axis controls the diabetogenic actions of PPARγ
- The emerging role of CDK5 in cancer
- LncRNA TTN-AS1 promotes migration, invasion, and epithelial mesenchymal transition of lung adenocarcinoma via sponging miR-142-5p to regulate CDK5
- Inhibition of p25/CDK5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia
- Astrocyte NMDA receptors’ activity sustains neuronal survival through a CDK5 –Nrf2 pathway
- Targeted epigenetic remodeling of the CDK5 gene in nucleus accumbens regulates cocaine-and stress-evoked behavior
- Biological functions of CDK5 and potential CDK5 targeted clinical treatments
- … MALAT1 inhibits neuron apoptosis and neuroinflammation while stimulates neurite outgrowth and its correlation with miR-125b mediates PTGS2, CDK5 and FOXQ1 in …
- Memory enhancement by targeting CDK5 regulation of NR2B
- Downregulation of miR-124 in MPTP-treated mouse model of Parkinson’s disease and MPP iodide-treated MN9D cells modulates the expression of the calpain/CDK5 …
- Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma
- Deactivation of excitatory neurons in the prelimbic cortex via CDK5 promotes pain sensation and anxiety
- Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5 -mediated autophagy and SNCA/α-synuclein aggregation
- Loss of mitofusin 2 links beta‐amyloid‐mediated mitochondrial fragmentation and CDK5 ‐induced oxidative stress in neuron cells
- A kinase of many talents: non-neuronal functions of CDK5 in development and disease
- CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death
- CDK5 -dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
- CDK5 -dependent phosphorylation of CaV3. 2 T-type channels: possible role in nerve ligation-induced neuropathic allodynia and the compound action potential in …
- Tale of the good and the bad CDK5 : remodeling of the actin cytoskeleton in the brain
- Ischemic stroke injury is mediated by aberrant CDK5
- Folding of the cerebral cortex requires CDK5 in upper-layer neurons in gyrencephalic mammals
- Activation of CDK5 /p25 and tau phosphorylation following chronic brain hypoperfusion in rats involves micro RNA‐195 down‐regulation
- Loss of CDK5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore
- CDK5 -dependent inhibitory phosphorylation of Drp1 during neuronal maturation
- Stress-induced CDK5 activation disrupts axonal transport via Lis1/Ndel1/Dynein
- Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/CDK5 -dependent pathway
- CDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5–AP-1 axis
- CDK5 : key regulator of apoptosis and cell survival
- CDK5 induces constitutive activation of 5-HT6 receptors to promote neurite growth
- Metformin ameliorates synaptic defects in a mouse model of AD by inhibiting CDK5 activity
- Physiological and pathological roles of CDK5 : potential directions for therapeutic targeting in neurodegenerative disease
- The role of CDK5 in tumours and tumour microenvironments
- CDK5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses
- CDK5 activator protein p25 preferentially binds and activates GSK3β
- CDK5 knockdown prevents hippocampal degeneration and cognitive dysfunction produced by cerebral ischemia
- … synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5 ) alters the ratio …
- mPTP opening caused by CDK5 loss is due to increased mitochondrial Ca2+ uptake
- A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by CDK5
- CDK5 –Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer’s disease models
- CDK5 /FBW7-dependent ubiquitination and degradation of EZH2 inhibits pancreatic cancer cell migration and invasion
- Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with a loss-of-function mutation in CDK5
- CDK5 -mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis
- Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders
- … peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5 ) and improves insulin …
- Neuroprotective mechanisms mediated by CDK5 inhibition
- Physiological concentrations of amyloid beta regulate recycling of synaptic vesicles via alpha7 acetylcholine receptor and CDK5 /calcineurin signaling
- Development of CDK2 and CDK5 dual degrader TMX‐2172
- AC1MMYR2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21/CDK5 axis
- Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma
- Endothelial CDK5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis
- Inhibition of endothelial CDK5 reduces tumor growth by promoting non-productive angiogenesis
- CDK5 knocking out mediated by CRISPR-Cas9 genome editing for PD-L1 attenuation and enhanced antitumor immunity
- Perinatal exposure to lead (Pb) promotes Tau phosphorylation in the rat brain in a GSK-3β and CDK5 dependent manner: Relevance to neurological disorders
- CDK5 -mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex
- Crosstalk between CDK5 /p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury
- The inhibition of CDK5 activity after hypoxia/ischemia injury reduces infarct size and promotes functional recovery in neonatal rats
- Dual inhibition of GSK3β and CDK5 protects the cytoskeleton of neurons from neuroinflammatory-mediated degeneration in vitro and in vivo
- Zinc induces CDK5 activation and neuronal death through CDK5 -Tyr15 phosphorylation in ischemic stroke
- TIGAR regulates DNA damage and repair through pentosephosphate pathway and CDK5 -ATM pathway
- Inhibition of CDK5 increases osteoblast differentiation and bone mass and improves fracture healing
- CDK5 : a unique CDK and its multiple roles in the nervous system
- CDK5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons
- Fusobacterium nucleatum Promotes the Progression of Colorectal Cancer Through CDK5 -Activated Wnt/β-Catenin Signaling
- Phosphorylation of cyclin-dependent kinase 5 (CDK5 ) at Tyr-15 is inhibited by CDK5 activators and does not contribute to the activation of CDK5
- CDK5 functions as a tumor promoter in human lung cancer
- (S)-Lacosamide binding to collapsin response mediator protein 2 (CRMP2) regulates CaV2. 2 activity by subverting its phosphorylation by CDK5
- CDK5 is a major regulator of the tumor suppressor DLC1
- Reduction of ciliary length through pharmacologic or genetic inhibition of CDK5 attenuates polycystic kidney disease in a model of nephronophthisis
- Inhibition of CDK5 promotes β-cell differentiation from ductal progenitors
- PARP Inhibition Suppresses GR–MYCN–CDK5 –RB1–E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate CancerPARP Inhibition …
- Phloretin and phloridzin improve insulin sensitivity and enhance glucose uptake by subverting PPARγ/CDK5 interaction in differentiated adipocytes
- CDK5 increases MARK4 activity and augments pathological tau accumulation and toxicity through tau phosphorylation at Ser262
- The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent CDK5 -dependent mechanism
- TNF-α increases production of reactive oxygen species through CDK5 activation in nociceptive neurons
- Curcumin downregulates GSK3 and CDK5 in scopolamine-induced Alzheimer’s disease rats abrogating Aβ 40/42 and tau hyperphosphorylation
- Amyloid-ß promotes neurotoxicity by CDK5 -induced p53 stabilization
- CDK5 controls lymphatic vessel development and function by phosphorylation of Foxc2
- The BRCC3 regulated by CDK5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson’s disease models
- CDK5 regulation of the GRAB-mediated Rab8-Rab11 cascade in axon outgrowth
- CDK5 -mediated phosphorylation and autophagy of RKIP regulate neuronal death in Parkinson’s disease
- Sex-specific regulation of fear memory by targeted epigenetic editing of CDK5
- The role of CDK5 ‐mediated Drp1 phosphorylation in Aβ1‐42 induced mitochondrial fission and neuronal apoptosis
- Peptide TFP5/TP5 derived from CDK5 activator P35 provides neuroprotection in the MPTP model of Parkinson’s disease
- Computational simulations identified two candidate inhibitors of CDK5 /p25 to abrogate tau-associated neurological disorders
- … RNA MALAT1 and its target microRNA-125b are potential biomarkers for Alzheimer’s disease management via interactions with FOXQ1, PTGS2 and CDK5
- CDK5 in oncology: recent advances and future prospects
- An immunohistochemical study of cyclin-dependent kinase 5 (CDK5 ) expression in non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC): a …
- CDK5 -mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy
- Cyclin-dependent kinase 5 (CDK5 ) regulates the circadian clock
- Site-specific phosphorylation of Fbxw7 by CDK5 /p25 and its resulting decreased stability are linked to glutamate-induced excitotoxicity
- The driving role of the CDK5 /Tln1/FAKS732 axis in cancer cell extravasation dissected by human vascularized microfluidic models
- CDK5 -dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition
- ERK MAP kinase activation in spinal cord regulates phosphorylation of CDK5 at serine 159 and contributes to peripheral inflammation induced pain …
- CDK5 inhibition abrogates TNBC stem‐cell property and enhances anti‐PD‐1 therapy
- Calcium dysregulation and CDK5 -ATM pathway involved in a mouse model of fragile X-associated tremor/ataxia syndrome
- CDK5 -mediated CRMP2 phosphorylation is necessary and sufficient for peripheral neuropathic pain
- CDK5 /p35 functions as a crucial regulator of spatial learning and memory
- CDK5 inhibition resolves PKA/cAMP-independent activation of CREB1 signaling in glioma stem cells
- CDK5 ‐dependent activation of dynein in the axon initial segment regulates polarized cargo transport in neurons
- Searching for Novel CDK5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and CDK5 −/− Mice
- Identification and comparison of plant-derived scaffolds as selective CDK5 inhibitors against standard molecules: Insights from umbrella sampling simulations
- Enhancement of BACE1 activity by p25/CDK5 -mediated phosphorylation in Alzheimer’s disease
- Future aspects of CDK5 in prostate cancer: from pathogenesis to therapeutic implications
- CDK5 links with DNA damage response and cancer
- Long-and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer’s mice
- Cyclin I and p35 determine the subcellular distribution of CDK5
- CDK5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients
- CDK5 regulates paclitaxel sensitivity in ovarian cancer cells by modulating AKT activation, p21Cip1-and p27Kip1-mediated G1 cell cycle arrest and apoptosis
- Roscovitine, a CDK5 inhibitor, alleviates sevoflurane-induced cognitive dysfunction via regulation Tau/GSK3β and ERK/PPARγ/CREB signaling
- CDK5 regulates activity-dependent gene expression and dendrite development
- Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation
- Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5 ) activator and is involved in cell cycle regulation
- TFP5, a peptide derived from p35, a CDK5 neuronal activator, rescues cortical neurons from glucose toxicity
- Discovery of thienoquinolone derivatives as selective and ATP non-competitive CDK5 /p25 inhibitors by structure-based virtual screening
- TFP5, a peptide inhibitor of aberrant and hyperactive CDK5 /p25, attenuates pathological phenotypes and restores synaptic function in CK-p25Tg mice
- CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus
- ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma
- Hyperactive innate immunity causes degeneration of dopamine neurons upon altering activity of CDK5
- The atypical cyclin-dependent kinase 5 (CDK5 ) guards podocytes from apoptosis in glomerular disease while being dispensable for podocyte development
- p47Phox/CDK5 /DRP1-mediated mitochondrial fission evokes PV cell degeneration in the rat dentate gyrus following status epilepticus
- Both GSK-3β/CRMP2 and CDK5 /CRMP2 pathways participate in the protection of dexmedetomidine against propofol-induced learning and memory impairment in …
- Three decades of CDK5
- CDK5 suppression blocks SIRT1 degradation via the ubiquitin-proteasome pathway in Parkinson’s disease models
- Differential expression of cell cycle regulators in CDK5 -dependent medullary thyroid carcinoma tumorigenesis
- Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease
- Inhibition of CDK5 induces cell death of tumor-initiating cells
- p39 is responsible for increasing CDK5 activity during postnatal neuron differentiation and governs neuronal network formation and epileptic responses
- CDK5 knockdown in astrocytes provide neuroprotection as a trophic source via Rac1
- DYRK1A negatively regulates CDK5 -SOX2 pathway and self-renewal of glioblastoma stem cells
- Phosphorylation of CRMP2 by CDK5 regulates dendritic spine development of cortical neuron in the mouse hippocampus
- The peptide-directed lysosomal degradation of CDK5 exerts therapeutic effects against stroke
- CDK5 -mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway
- Deletion of CDK5 in Macrophages Ameliorates Anti-Inflammatory Response during Endotoxemia through Induction of C-Maf and Il-10
- … persistent chronic stress-induced behavioral deficits that are associated with prefrontal cortex activation of the p25/CDK5 -glucocorticoid receptor pathway
- CDK5 -mediated mitochondrial fission: a key player in dopaminergic toxicity in Huntington’s disease
- Cyclin I promotes cisplatin resistance via CDK5 activation in cervical cancer
- Fluorescent biosensor of CDK5 kinase activity in glioblastoma cell extracts and living cells
- CDK5 inhibitor roscovitine alleviates neuropathic pain in the dorsal root ganglia by downregulating N-methyl-D-aspartate receptor subunit 2A
- Cyclin-dependent kinase 5 (CDK5 ) controls melanoma cell motility, invasiveness, and metastatic spread—identification of a promising novel therapeutic target
- Adhesion GPCR latrophilin-2 specifies cardiac lineage commitment through CDK5 , Src, and P38MAPK
- LRRK2 facilitates tau phosphorylation through strong interaction with tau and CDK5
- Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates CDK5 expression
- p39-associated CDK5 activity regulates dendritic morphogenesis
- Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted Pyrido [3, 2-d] pyrimidines as CDK5 and DYRK1A inhibitors
- CDK5 -mediated phosphorylation of Sirt1 contributes to podocyte mitochondrial dysfunction in diabetic nephropathy
- CDK5 -mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons
- Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration
- Phosphorylation of p53 by CDK5 contributes to benzo [a] pyrene‐induced neuronal apoptosis
- Myricetin prevents thapsigargin-induced CDK5 -P66Shc signalosome mediated pancreatic β-cell dysfunction
- Nestin selectively facilitates the phosphorylation of the Lissencephaly-linked protein doublecortin (DCX) by CDK5 /p35 to regulate growth cone morphology and …
- CDK5 inhibitor downregulates Mcl-1 and sensitizes pancreatic cancer cell lines to navitoclax
- The CDK5 -Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in a model of Alzheimer’s disease
- S-nitrosylation-dependent proteasomal degradation restrains CDK5 activity to regulate hippocampal synaptic strength
- The roles of CDK5 -mediated subcellular localization of FOXO1 in neuronal death
- The early synthesis of p35 and activation of CDK5 in LPS-stimulated macrophages suppresses interleukin-10 production
- CDK5 activates hippo signaling to confer resistance to radiation therapy via upregulating TAZ in lung cancer
- … effects of phosphocreatine on Amyloid Beta 25–35-induced differentiated neuronal cell death through inhibition of AKT/GSK-3β/Tau/APP/CDK5 pathways in vivo and …
- Parkinson-related LRRK2 mutation R1628P enables CDK5 phosphorylation of LRRK2 and upregulates its kinase activity
- Phosphorylation of CHIP at Ser20 by CDK5 promotes tAIF-mediated neuronal death
- The BDNF/TrkB signaling pathway is involved in heat hyperalgesia mediated by CDK5 in rats
- Stress-induced CDK5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437
- Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+‑calpain‑p25‑CDK5 pathway in HT22 cells
- Abnormal mitochondria in a non-human primate model of MPTP-induced Parkinson’s disease: Drp1 and CDK5 /p25 signaling
- A mitotic CDK5 -PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1
- CDK5 downregulation enhances synaptic plasticity
- Tumor expression of cyclin-dependent kinase 5 (CDK5 ) is a prognostic biomarker and predicts outcome of oxaliplatin-treated metastatic colorectal cancer patients
- APOE4 induces site-specific tau phosphorylation through calpain-CDK5 signaling pathway in EFAD-Tg mice
- Role of CDK5 in amyloid-beta pathology of Alzheimer’s disease
- Identification of the first PPARα/γ dual agonist able to bind to canonical and alternative sites of PPARγ and to inhibit its CDK5 -mediated phosphorylation
- Discovery of CDK5 inhibitors through structure-guided approach
- CDK5 and GSK3β inhibit fast endophilin-mediated endocytosis
- CDK5 contributes to neuronal apoptosis via promoting MEF2D phosphorylation in rat model of intracerebral hemorrhage
- PKA and CDK5 can phosphorylate specific serines on the intracellular domain of podoplanin (PDPN) to inhibit cell motility
- Multifaceted regulation of ALDH1A1 by CDK5 in Alzheimer’s disease pathogenesis
- Inhibition of CDK5 alleviates the cardiac phenotypes in Timothy syndrome
- Two degradation pathways of the p35 CDK5 (Cyclin-dependent Kinase) activation subunit, dependent and independent of ubiquitination
- L5-6 Spinal Nerve Ligation-induced Neuropathy Changes the Location and Function of Ca2+ Channels and CDK5 and Affects the Compound Action Potential in …
- Epigenetic upregulation of CDK5 in the dorsal horn contributes to neuropathic pain in rats
- Ginsenoside Rb1 improves cognitive impairment induced by insulin resistance through CDK5 /p35-NMDAR-IDE pathway
- The role of the drebrin/EB3/CDK5 pathway in dendritic spine plasticity, implications for Alzheimer’s disease
- Consensus models for CDK5 inhibitors in silico and their application to inhibitor discovery
- CDK5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons
- Neuroprotection induced by transplanted CDK5 knockdown astrocytes in global cerebral ischemic rats
- All-trans retinoic acid induces DU145 cell cycle arrest through CDK5 activation
- Targeting CDK5 post-stroke provides long-term neuroprotection and rescues synaptic plasticity
- Phosphorylation of connexin 43 by CDK5 modulates neuronal migration during embryonic brain development
- CDK5 -mediated phosphorylation-dependent ubiquitination and degradation of E3 ubiquitin ligases GP78 accelerates neuronal death in Parkinson’s disease
- CDK5 and its activator P35 in normal pituitary and in pituitary adenomas: relationship to VEGF expression
- Recovery of neurovascular unit integrity by CDK5 -KD astrocyte transplantation in a global cerebral ischemia model
- Low expression of CDK5 and p27 are associated with poor prognosis in patients with gastric cancer
- Posterior neocortex-specific regulation of neuronal migration by CEP85L identifies maternal centriole-dependent activation of CDK5
- p35 and Rac1 underlie the neuroprotection and cognitive improvement induced by CDK5 silencing
- TRPV1 function is modulated by CDK5 -mediated phosphorylation: insights into the molecular mechanism of nociception
- … for PPAR non-agonist ligands followed by characterization of a hit, AM-879, with additional no-adipogenic and CDK5 -mediated phosphorylation inhibition …
- Exploring the mechanism of PPARγ phosphorylation mediated by CDK5
- CDK5 controls IL-2 gene expression via repression of the mSin3a-HDAC complex
- High glucose increases CDK5 activity in podocytes via transforming growth factor-β1 signaling pathway
- Discovery and Optimization of Highly Selective Inhibitors of CDK5
- CDK5 drives formation of heterogeneous pancreatic neuroendocrine tumors
- CDK5 suppresses the metastasis of gastric cancer cells by interacting with and regulating PP2A
- CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via ERK1/2/PPARγ pathway
- CK1δ activity is modulated by CDK2/E-and CDK5 /p35-mediated phosphorylation
- Hypoxia induces HT-22 neuronal cell death via Orai1/CDK5 pathway-mediated Tau hyperphosphorylation
- Wnt-5a promotes neural development and differentiation by regulating CDK5 via Ca2+/calpain pathway
- CDK5 participates in amyloid-β production by regulating PPARγ phosphorylation in primary rat hippocampal neurons
- TFP5 peptide, derived from CDK5 -activating cofactor p35, provides neuroprotection in early-stage of adult ischemic stroke
- The role of cyclin dependent kinase 5 (CDK5 ) in neuropathic pain
- CDK5 contributes to inflammation-induced thermal hyperalgesia mediated by the p38 MAPK pathway in microglia
- CDK5 : a key player at neuronal synapse with diverse functions
- CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC
- Synapsin III acts downstream of semaphorin 3A/CDK5 signaling to regulate radial migration and orientation of pyramidal neurons in vivo
- Physical Interaction between Cyclin-Dependent Kinase 5 (CDK5 ) and Clock Factors Affects the Circadian Rhythmicity in Peripheral Oscillators
- The O-GlcNAc modification of CDK5 involved in neuronal apoptosis following in vitro intracerebral hemorrhage
- Phosphorylation of STAT3 by axonal CDK5 promotes axonal regeneration by modulating mitochondrial activity
- Generation of the CDK5 activator p25 is a memory mechanism that is affected in early Alzheimer’s disease
- Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ss and CDK5 following traumatic brain injury
- CDK4 and CDK5 inhibition have comparable mild hypothermia effects in preventing Drp1-dependent mitochondrial fission and neuron death induced by MPP+
- CDK5 -mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition
- CDK5 inhibitory peptide prevents loss of dopaminergic neurons and alleviates behavioral changes in an MPTP induced Parkinson’s disease mouse model
- Valproic acid increases NO production via the SH-PTP1–CDK5 –eNOS-Ser116 signaling cascade in endothelial cells and mice
- CDK5 inhibition in vitro and in vivo induces cell death in myeloma and overcomes the obstacle of bortezomib resistance
- Colocalization of phosphorylated forms of WAVE1, CRMP2, and tau in Alzheimer’s disease model mice: involvement of CDK5 phosphorylation and the effect of ATRA …
- CDK5 positively regulates Notch1 signaling in pancreatic cancer cells by phosphorylation
- CDK5 -mediated phosphorylation of Sirt2 contributes to depressive-like behavior induced by social defeat stress
- CDK5 phosphorylation of STAT3 in dorsal root ganglion neurons is involved in promoting axonal regeneration after peripheral nerve injury
- CDK5 targeting as a therapy for recovering neurovascular unit integrity in Alzheimer’s disease
- Learning impairments, memory deficits, and neuropathology in aged tau transgenic mice are dependent on leukotrienes biosynthesis: role of the CDK5 kinase pathway
- Downregulation of CDK5 restores sevoflurane-induced cognitive dysfunction by promoting SIRT1-mediated autophagy
- Exploring structural requirements of leads for improving activity and selectivity against CDK5 /p25 in Alzheimer’s disease: an in silico approach
- Targeting MicroRNA-125b promotes neurite outgrowth but represses cell apoptosis and inflammation via Blocking PTGS2 and CDK5 in a FOXQ1-dependent …
- O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5 -dependent ACSS2 phosphorylation
- Adeno‐associated virus 9–mediated CDK5 inhibitory peptide reverses pathologic changes and behavioral deficits in the Alzheimer’s disease mouse model
- Phosphorylation by PKA and CDK5 mediates the early effects of synapsin III in neuronal morphological maturation
- Crocin improves insulin sensitivity and ameliorates adiposity by regulating AMPK-CDK5 -PPARγ signaling
- Phosphorylation of Tet3 by CDK5 is critical for robust activation of BRN2 during neuronal differentiation
- Ubiquitin ligase activity inhibits CDK5 to control axon termination
- Suppressing CDK5 Activity by Luteolin Inhibits MPP+-Induced Apoptotic of Neuroblastoma through Erk/Drp1 and Fak/Akt/GSK3β Pathways
- Targeting CDK5 in Astrocytes Promotes Calcium Homeostasis Under Excitotoxic Conditions
- CDK5 -mediated phosphorylation of XBP1s contributes to its nuclear translocation and activation in MPP+-induced Parkinson’s disease model
- Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation
- Diabetes-induced H3K9 hyperacetylation promotes development of Alzheimer’s disease through CDK5
- CDK5 -dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development
- Roles of Id1/HIF-1 and CDK5 /HIF-1 in cell cycle reentry induced by amyloid-beta peptide in post-mitotic cortical neuron
- CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2
- Cyclin-dependent kinase 5 (CDK5 )-dependent phosphorylation of p70 ribosomal S6 kinase 1 (S6K) is required for dendritic spine morphogenesis
- CDK5 phosphorylation-induced SIRT2 nuclear translocation promotes the death of dopaminergic neurons in Parkinson’s disease
- Differential expression of CDK5 -phosphorylated CRMP2 following a spared nerve injury
- CK2 inhibition confers functional protection to young and aging axons against ischemia by differentially regulating the CDK5 and AKT signaling pathways
- RET regulates human medullary thyroid cancer cell proliferation through CDK5 and STAT3 activation
- Roscovitine, an experimental CDK5 inhibitor, causes delayed suppression of microglial, but not astroglial recruitment around intracerebral dopaminergic grafts
- Neuregulin-1β plays a neuroprotective role by inhibiting the CDK5 signaling pathway after cerebral ischemia-reperfusion injury in rats
- Characterization of the CDK5 gene in Apis cerana cerana (AccCDK5 ) and a preliminary identification of its activator gene, AccCDK5 r1
- CB1R regulates CDK5 signaling and epigenetically controls Rac1 expression contributing to neurobehavioral abnormalities in mice postnatally exposed to ethanol
- CDK5 deletion enhances the anti-inflammatory potential of GC-mediated GR activation during inflammation
- Quantitative Phosphoproteomic analysis in alpha-Synuclein transgenic mice reveals the involvement of aberrant p25/CDK5 signaling in early-stage Parkinson’s …
- Dissociative role for dorsal hippocampus in mediating heroin self‐administration and relapse through CDK5 and RhoB signaling revealed by proteomic analysis
- CDK5 is required for the neuroprotective effect of transforming growth factor-β1 against cerebral ischemia-reperfusion
- Protocols for Characterization of CDK5 Kinase Activity
- Prenatal bisphenol A exposure contributes to Tau pathology: Potential roles of CDK5 /GSK3β/PP2A axis in BPA-induced neurotoxicity
- Heat shock inhibition of CDK5 increases NOXA levels through miR-23a repression
- Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male …
- Regulation of CRMP2 by CDK5 and GSK-3β participates in sevoflurane-induced dendritic development abnormalities and cognitive dysfunction in developing rats
- Computational Study of the Allosteric Effects of p5 on CDK5 –p25 Hyperactivity as Alternative Inhibitory Mechanisms in Neurodegeneration
- Metformin promotes neuronal differentiation via crosstalk between CDK5 and Sox6 in neuroblastoma cells
- Overexpression of the CDK5 inhibitory peptide in motor neurons rescue of amyotrophic lateral sclerosis phenotype in a mouse model
- Knockdown of expression of CDK5 or p35 (a CDK5 activator) results in podocyte apoptosis
- Cyclic AMP and polyamines overcome inhibition by myelin-associated glycoprotein through eIF5A-mediated increases in p35 expression and activation of CDK5
- CDK5 inhibitory peptide prevents loss of neurons and alleviates behavioral changes in p25 transgenic mice
- CDK5 phosphorylation of EFhd2 at S74 affects its calcium binding activity
- CDK5 contributes to Huntington’s disease learning and memory deficits via modulation of brain region-specific substrates
- Opiate exposure state controls dopamine D3 receptor and CDK5 /calcineurin signaling in the basolateral amygdala during reward and withdrawal aversion memory …
- Oligodendrocyte-specific loss of CDK5 disrupts the architecture of nodes of Ranvier as well as learning and memory
- Involvement of CDK5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons
- The CDK5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens
- Designing of dual inhibitors for GSK-3β and CDK5 : Virtual screening and in vitro biological activities study
- Molecular recognition of PPARγ by kinase CDK5 /p25: Insights from a combination of protein–protein docking and adaptive biasing force simulations
- Three-dimensional structural analysis reveals a CDK5 -mediated kinase cascade regulating hepatic biliary network branching in zebrafish
- PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating CDK5 through ERK1/2 signaling pathway
- The CDK5 inhibitor Roscovitine increases LTP induction in corticostriatal synapses
- Two-hour acute restraint stress facilitates escape behavior and learning outcomes through the activation of the CDK5 /GR P S211 pathway in male mice
- Discovery by Virtual Screening of an Inhibitor of CDK5 -Mediated PPARγ Phosphorylation
- Streptozotocin Induces Alzheimer’s Disease-Like Pathology in Hippocampal Neuronal Cells via CDK5 /Drp1-Mediated Mitochondrial Fragmentation
- Functional characterization of CDK5 and CDK5 R1 mutations identified in patients with non-syndromic intellectual disability
- Phosphorylation of CRMP2 by CDK5 negatively regulates the surface delivery and synaptic function of AMPA receptors
- TP5, a peptide inhibitor of aberrant and hyperactive CDK5 /p25: A novel therapeutic approach against glioblastoma
- CDK5 phosphorylates CaV1. 3 channels and regulates GABAA-mediated miniature inhibitory post-synaptic currents in striato-nigral terminals
- Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528
- Modulation of TRPA1 channel activity by CDK5 in sensory neurons
- CDK5 is essential for amphetamine to increase dendritic spine density in hippocampal pyramidal neurons
- Regional specific activations of ERK1/2 and CDK5 differently regulate astroglial responses to ER stress in the rat hippocampus following status epilepticus
- Calpain-2/p35-p25/CDK5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153
- Novel optimization of valmerins (tetrahydropyrido [1, 2-a] isoindolones) as potent dual CDK5 /GSK3 inhibitors
- Targeting CDK5 for killing of breast cancer cells via perturbation of redox homeostasis
- Estrogen improved the regeneration of axons after subcortical axon injury via regulation of PI3K/Akt/CDK5 /Tau pathway
- Role of CDK5 in Kalirin7-mediated formation of dendritic spines
- Dendritic distribution of CDK5 mRNA and p35 mRNA, and a glutamate-responsive increase of CDK5 /p25 complex contribute to tau hyperphosphorylation
- Inhibition of CDK5 rejuvenates inhibitory circuits and restores experience-dependent plasticity in adult visual cortex
- AAV9-mediated CDK5 inhibitory peptide reduces hyperphosphorylated tau and inflammation and ameliorates behavioral changes caused by overexpression of p25 in …
- CDK5 -mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive …
- Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in mice
- Loss of CDK5 function in the nucleus accumbens decreases wheel running and may mediate age‐related declines in voluntary physical activity
- Olfactory deprivation hastens Alzheimer-like pathologies in a human tau-overexpressed mouse model via activation of CDK5
- CDK5 Knockdown inhibits proliferation and induces apoptosis and Cell Cycle Arrest in Human Glioblastoma
- Inhibition of CDK5 in PV Neurons Reactivates Experience-Dependent Plasticity in Adult Visual Cortex
- Inhibition of CDK5 Ameliorates Skeletal Bone Loss in Glucocorticoid-Treated Mice
- Altered expression of the CDK5 activator-like protein, CDK5 α, causes neurodegeneration, in part by accelerating the rate of aging
- Valproic acid downregulates CDK5 activity via the transcription of the p35 mRNA
- CDK5 regulatory subunit-associated protein 1-like 1 negatively regulates adipocyte differentiation through activation of Wnt signaling pathway
- Preferential targeting of p39-activated CDK5 to Rac1-induced lamellipodia
- Interaction of CDK5 and cAMP/PKA signaling in the mediation of neuropsychiatric and neurodegenerative diseases
- The S. pombe CDK5 ortholog Pef1 regulates sexual differentiation through control of the TORC1 pathway and autophagy
- Vps35 deficiency impairs CDK5 /p35 degradation and promotes the hyperphosphorylation of tau protein in retinal ganglion cells
- CDK5 ‐mediated phosphorylation regulates phosphatidylinositol 4‐phosphate 5‐kinase type I γ 90 activity and cell invasion
- In vivo analysis of the phosphorylation of tau and the tau protein kinases CDK5 -p35 and GSK3β by using Phos-tag SDS–PAGE
- Suppression of neuroinflammation in forebrain-specific CDK5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality
- Effects of Single-Dose and Long-Term Ketamine Administration on Tau Phosphorylation–Related Enzymes GSK-3β, CDK5 , PP2A, and PP2B in the Mouse …
- CDK5 regulatory subunit-associated protein 1 knockout mice show hearing loss phenotypically similar to age-related hearing loss
- CDK5 -mediated Acn/Acinus phosphorylation regulates basal autophagy independently of metabolic stress
- CDK5 inhibition improves glucose uptake in insulin‐resistant neuronal cells via ERK1/2 pathway
- Lnc-ATG9B-4 aggravates progress of hepatocellular carcinoma through cell proliferation and migration by upregulating CDK5
- Valproic Acid-Induced Anxiety and Depression Behaviors are Ameliorated in p39 CDK5 Activator-Deficient Mice
- Low p-SYN1 (Ser-553) Expression Leads to Abnormal Neurotransmitter Release of GABA Induced by Up-Regulated CDK5 after Microwave Exposure: Insights …
- Computational simulations identify pyrrolidine-2, 3-dione derivatives as novel inhibitors of CDK5 /p25 complex to attenuate Alzheimer’s pathology
- Deficiency of Parkinson’s Related Protein DJ-1 Alters CDK5 Signalling and Induces Neuronal Death by Aberrant Cell Cycle Re-entry
- CDK5 /p25 specific inhibitory peptide TFP5 rescues the loss of dopaminergic neurons in a sub-acute MPTP induced PD mouse model
- Epigenetic control of CDK5 promoter regulates diabetes-associated development of Alzheimer’s disease
- Tissue-type plasminogen activator regulates p35-mediated CDK5 activation in the postsynaptic terminal
- Inactivated AMPK-α2 promotes the progression of diabetic brain damage by CDK5 phosphorylation at Thr485 site
- Overexpression of CDK5 in neural stem cells facilitates maturation of embryonic neurocytes derived from rats in vitro
- Clozapine induces chloride channel-4 expression through PKA activation and modulates CDK5 expression in SH-SY5Y and U87 cells
- Studying nestin and its interrelationship with CDK5
- Tfh Exosomes Derived from Allergic Rhinitis Promote DC Maturation Through miR-142-5p/CDK5 /STAT3 Pathway
- Prenatal alcohol exposure alters p35, CDK5 and GSK3β in the medial frontal cortex and hippocampus of adolescent mice
- CDK5 Regulatory Subunit-Associated Protein 1-Like 1 Gene Polymorphisms and Gestational Diabetes Mellitus Risk: A Trial Sequential Meta-Analysis of …
- … profiled 3-ethoxycarbonyl-1-aza-9-oxafluorenes representing a perspective compound class targeting Alzheimer disease relevant kinases CDK1, CDK5 and GSK-3β
- Regulation of growth hormone biosynthesis by CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1) in pituitary adenomas
- MultiBacMam Bimolecular Fluorescence Complementation (BiFC) tool-kit identifies new small-molecule inhibitors of the CDK5 -p25 protein-protein interaction …
- Computational study of the inhibitory mechanism of the kinase CDK5 hyperactivity by peptide p5 and derivation of a pharmacophore
- CDK5 /NFAT5-Regulated Transporters Involved in Osmoregulation in Fejervarya cancrivora
- Nociceptive signaling through TRPV1 is regulated by CDK5 -mediated phosphorylation of T407 in vivo
- The S. pombe CDK5 Orthologue Pef1 Cooperates with Three Cyclins, Clg1, Pas1 and Psl1, to Promote Pre-Meiotic DNA Replication
- Visualization of trigeminal ganglion sensory neuronal signaling regulated by CDK5
- The HU177 collagen epitope controls melanoma cell migration and experimental metastasis by a CDK5 /YAP-dependent mechanism
- The LPA-CDK5 -tau pathway mediates neuronal injury in an in vitro model of ischemia-reperfusion insult
- A cyclin-dependent kinase 5-derived peptide inhibits CDK5 /p25 activity and improves neurodegenerative phenotypes
- VGLUT2/CDK5 /p25 signaling pathway contributed to inflammatory pain by complete Freund’s adjuvant
- CDK5 regulates developmental remodeling of mushroom body neurons in Drosophila
- Mechanism of CDK5 -synaptophysin-SNARE pathway in acute and chronic inflammatory pain
- CDK5 and MAPT gene expression in Alzheimer’s disease brain samples
- Prognostic significance of the CDK5 gene in breast cancer: an in silico study
- Profiling of p5, a 24 amino acid inhibitory peptide derived from the CDK5 activator, p35 CDKR1 against 70 protein kinases
- CDK5 Mediates Proinflammatory Effects of Microglia through Activated DRP1 Phosphorylation in Rat Model of Intracerebral Hemorrhage
- Long non-coding RNA expression profile in CDK5 -knockdown mouse skin
- Role of CDK5 /cyclin complexes in ischemia-induced death and survival of renal tubular cells
- CSIG-24. TARGETED INHIBITION OF CDK5 -MEDIATED REGULATION OF HUMAN ENDOGENOUS RETROVIRUS K (HML-2) ENVELOPE PROTEIN IN ATYPICAL …
- Association between the expression of amphetamine-induced behavioral sensitization and CDK5 /p35 activity in dorsal striatum.
- Differential regulation of excitatory synaptic transmission in the hippocampus and anterior temporal lobe by cyclin dependent kinase 5 (CDK5 ) in mesial temporal lobe …
- LMW cyclin E and its novel catalytic partner CDK5 are therapeutic targets and prognostic biomarkers in salivary gland cancers
- Changes in the prefrontal cortex after the hippocampus was injected with Aβ25-35 via the P35/P25-CDK5 -Tau hyperphosphorylation signaling pathway
- Decreased synapse‐associated proteins are associated with the onset of epileptic memory impairment in endothelial CDK5 ‐deficient mice
- Potential mechanisms underlying CDK5 related Osteosarcoma progression
- Over-expression of CDK5 in human endometrial cancer.
- CDK3, CDK5 and CDK8 Proteins as Prognostic and Potential Biomarkers in Colorectal Cancer Patients
- Protective effect of valproic acid on MPP+-induced neurotoxicity in dopaminergic SH-SY5Y cells through CDK5 /p35/Erk signaling cascade
- Inhibition of the CDK5 /caspase-3 Pathway by p5-TAT Protects Hippocampal Neurogenesis and Alleviates Radiation-induced Cognitive Dysfunction
- Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and CDK5 /p25
- CDK5 Regulates PD-L1 expression and cell maturation in dendritic cells of CRSwNP
- Therapeutic effects of TP5, a CDK5 /p25 inhibitor, in in vitro and in vivo models of Parkinson’s disease
- Amyloid-β fosters p35/CDK5 signaling contributing to changes of inhibitory synapses in early stages of cerebral amyloidosis
- CDK5 inhibition protects against OGDR induced mitochondrial fragmentation and apoptosis through regulation of Drp1S616 phosphorylation
- … transient protein-protein interactions that regulate the activity of human lemur tyrosine kinase-3 (LMTK3) domain by cyclin dependent kinase 5 (CDK5 ) in breast cancer …
- Identification and Verification of the Ability of CDK5 to Phosphorylate Deubiquitinating Enzyme BRCC3 In Vitro
- Microtubule plus-end tracking of end-binding protein 1 (EB1) is regulated by CDK5 regulatory subunit-associated protein 2
- Endothelium-derived CDK5 deficit aggravates air pollution-induced peripheral vasoconstriction through AT1R upregulation
- Extracellular CIRP Activates the IL-6Rα/STAT3/CDK5 Pathway in Neurons
- Influence of CDK5 Regulatory Subunit-Associated Protein 1-Like 1 Expression on the Survival of Patients with Non-Metastatic Nasopharyngeal Carcinoma
- THE EFFECT OF ENDURANCE TRAINING ON GENE EXPRESSION OF CDK5 IN SPINAL MOTOR PART OF MALE WISTAR RATS WITH DIABETIC NEUROPATHY
- Binding mechanism of CDK5 with roscovitine derivatives based on molecular dynamics simulations and MM/PBSA methods
- CDK5 and Foxc2–a new relationship in the lymphatic vasculature
- Active CDK5 immunoprecipitation and kinase assay
- Study of ATM phosphorylation by CDK5 in neuronal cells
- Correction: Corrigendum: Deactivation of excitatory neurons in the prelimbic cortex via CDK5 promotes pain sensation and anxiety
- Induction of CRMP‐2 phosphorylation by CDK5 restricts the repair of damaged optic nerve
- … –assisted Function X (PIMAX) Approach to Producing Challenging Proteins Including Hyperphosphorylated Tau and Active CDK5 /p25 Kinase Complex
- Regulation of thin recipe of Buyang Huanwudecoction on CDK5 expression of rats after cerebral ischemia
- Analysis of the inhibitory elements in the p5 peptide fragment of the CDK5 activator, p35, CDKR1 protein
- The importance of regulatory role of panaxoside Rg1 in CDK5 on hippocampal neuron radioactive damage protection
- CDK5 inhibition promotes osteoblastic differentiation of MSCs and blocks the migration of osteosarcoma MG-63 cells
- MiR-26a regulated adipogenic differentiation of ADSCs induced by insulin through CDK5 /FOXC2 pathway
- Investigating the Role of CDK5 in Alzheimer’s Disease and Type‐2 Diabetes
- CDK5 regulates N-cadherin-dependent neuronal migration during cortical development
- Post-translational modifications of CDK5 and their biological roles in cancer
- Mesenchymal stem cells loaded with p5, derived from CDK5 activator p35, inhibit calcium-induced CDK5 activation in endothelial cells
- Motor learning and long‐term plasticity of parallel fibre‐Purkinje cell synapses require post‐synaptic CDK5 /p35
- Development of an ELISA for High-Throughput Screening of Inhibitors of CDK5 -Mediated PPARγ Phosphorylation
- Regulation on intercross effect between CDK5 mediated apoptosis and autophagy after cerebral ischemia
- Inhibition of CDK5 in colorectal cancer
- Lipopolysaccharide-induced inflammation in human peritoneal mesothelial cells is controlled by ERK1/2-CDK5 -PPARγ axis
- Effects of p35 mutations associated with mental retardation on the cellular function of p35-CDK5
- Restoration of CDK5 , TrkB and soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins after chronic methylphenidate treatment in …
- Analysis of CDK5 -related phosphoproteomics in growth cones
- Pooled shRNA screening using mouse xenografts of human hepatocellular carcinoma cells identifies CDK5 as a potential mechanism mediating sorafenib resistance
- Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy
- CDK5 is required for the positioning and survival of GABAergic neurons in developing mouse striatum
- Progress on Correlation between the Expression of CDK5 and Brain Injury Time
- Synapsin III Controls Early Phases of Dopaminergic Neurons Development in Fishes and Mammals by Acting Upstream of BDNF and CDK5 Signaling
- A rapid and sensitive bioanalytical LC–MS/MS method for the quantitation of a novel CDK5 inhibitor 20–223 (CP668863) in plasma: Application to in vitro metabolism …
- CDK5 activity is required for Purkinje cell dendritic growth in cell‐autonomous and non‐cell‐autonomous manners
- In silico study on the selective inhibition of Alzheimer’s disease (AD) pathological complex CDK5 -p25 by peptide p5 in presence of munc 18 (p67)
- Kinase CDK5 in tumors
- Hyperactive Innate Immunity Causes Degeneration of Dopamine Neurons upon Altering Activity of CDK5
- … reversion to oxaliplatin-acquired resistance in colorectal cancer cell lines through modulation of nuclear factor κB (NFκB) and cyclin-dependent kinase 5 (CDK5 )
- Getting Excited Through Cyclin: A Role for Endothelial CDK5 Signaling in Hippocampal Hyperexcitability
- O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5 -dependent ACSS2 phosphorylation
- CDK5 mediated phosphorylation of cytosolic phospholipase A2 regulates its activity and neuroinflammation in Parkinson’s Disease
- Notch and CDK5 in Zebrafish Mindbomb Mutant: Co-regulation or Coincidence?
- Erratum: Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5 ) activator and is involved in cell cycle regulation
- Quantitative phosphoproteomics reveals regulatory state dependent efficacy of chemical Cdk1 inhibition and distinct CDK5 complexes as novel Wee1 substrates
- Correction to: ARNTL hypermethylation promotes tumorigenesis and inhibits cisplatin sensitivity by activating CDK5 transcription in nasopharyngeal carcinoma
- Downregulation of CDK5 Signaling In the Dorsal Striatum Alters Striatal Microcircuits and Perturbs Circadian Behavior in Mice
- TFP5, a Peptide Derived From CDK5 Activator p35, Protects Pancreatic β-Cells From Glucose Toxicity
- CDK5 and epithelial-mesenchymal transition related proteins are abnormally expressed in head and neck squamous cell carcinoma
- Ameliorating Alzheimer’s-like pathology by Minocycline via inhibiting CDK5 /p25 signaling.
- The S. pombe CDK5 Orthologue Pef1 Cooperates with Three Cyclins, Clg1, Pas1 and Psl1, to Promote Pre-Meiotic DNA Replication. Biomolecules 2021, 11 …
- Lack of CDK5 activity is involved on Dopamine Transporter expression and function: Evidences from an animal model of Attention-Deficit Hyperactivity Disorder
- Differential expression of CDK5 -phosphorylated CRMP2 following a spared nerve injury
- PO-447 CDK5 as a prognostic and predictive factor in colorectal cancer patients
- CDK5 : The Connection Between Alzheimer’s Disease and Type 2 Diabetes?
- Evaluation of CDK5 inhibitors in neural crest tumors
- Correction to: CDK5 regulates PD-L1 expression and cell maturation in dendritic cells of CRSwNP
- A deficitary model of CDK5 does not impairs neuronal differentiation of human pluripotent stem cells
- CDK5 negatively regulates Rho by phosphorylating and activating the Rho-GAP and tumor suppressor functions of DLC1
- The Role of CDK5 in Tumours and Tumour Microenvironments. Cancers 2021, 13, 101
- CDK5 influences the organization of the Circadian Machinery in peripheral clocks.
- A concise review on cyclin dependent kinase 5 (CDK5 ) inhibitors
- Interplay between CDK5 and IRF2BP1 enhances breast cancer brain metastasis
- CDK5 Activation Drives Pancreatic Neuroendocrine Tumorigenesis and is a Therapeutic Target
- Impact of Phosphorylation of CDK5 at Residues Serine 46 and Serine 47 on Its Activity and Function
- EPAC2 knockout causes abnormal tau pathology through calpain-mediated CDK5 activation
- CDK5 -dependent inhibitory phosphorylation of Drp1 during neuronal maturation
- Identification and Verification of CDK5 Phosphorylated Deubiquitinating Enzyme BRCC3
- Potential Benefits of Melatonergic Treatment in Schizophrenia: Ameliorating Demyelination via Inhibiting CDK5 -Mediated Hyper Autophagy
- CDK5 Loss Alters Mitochondrial Cristae Organization
- PTGS2, CD133, CDK5 knockout comparison by CRISPR CAS-9 system in UV-Induced and Metastatic Melanoma
- Characterization of neurochemical activities through inhibition of CDK5 or AChE by dimers of tacrine and neostigmine respectively
- A novel role of CDK5 in tumor growth, migration and proliferation of breast cancer cell lines MDA-MB-231 and BT-474
- CDK5 Inhibitor Seliciclib Promotes Osteoblastic Differentiation of MSCs and Suppresses the Migration of MG-63 Osteosarcoma Cells
- CDK5 /CAMK2-DRP1-AMPK-Mediated Mitochondrial Fission is Required for Imatinib Resistance of CML Cells
- The effect of CDK5 on mitochondrial function in Glioblastoma Multiforme (GBM)
- Functional Characterization of the Interaction Between Alkali Cation/Proton Exchanger SLC9A6/NHE6 and Cyclin Dependent Kinase 5 (CDK5 )
- Seasonal changes in actin and CDK5 expression in different brain regions of the Yakut ground squirrel (Spermophilus undulatus)
- DDIS-27. TARGETING ATP DOCKING AND P35/P25 BINDING OF CDK5 IN GLIOMA STEM CELLS USING SYNTHETIC INHIBITORS
- Association of CDK5 and soluble oligomeric species of β-amyloid induced tau hyperphosphorylation
- CDK5 influences the organization of the Circadian Machinery in peripheral clocks.
- IN SILICO DESIGN OF QUERCETIN DERIVATIVES WITH POTENTIAL DUAL INHIBITORY ACTIVITY AGAINST GSK3β AND CDK5 /P25 FOR THE TREATMENT OF …
- The loss of function of Cyclin-Dependent Kinase 5 (CDK5 ) alters the Cytoskeleton and decrease the in vitro Dengue Virus-2 infection
- CDK5 Involvement in Cancer and in the Tumor Microenvironment
- STEM-19. RESISTANCE IS FUTILE: UNDERSTANDING AND TARGETING THE CDK5 -CREB1-MCL1 AXIS TO PREVENT RADIATION RESISTANCE IN GLIOMA …
- OGT/CDK5 /ACSS2 Axis Regulates Breast Cancer Brain Metastasis Growth.
- The Role of CDK5 and TRPV1 in Meloxicam Resistance Signal Transduction in Rat Experiencing Chronic Pain.
- CDK5 as a possible new target in biliary tract cancer: preliminary in-situ findings
- Expression of CDK5 and its correlation with peripheral inflammation-related cells and prognosis in colon cancer patients
- Studies on the regulatory mechanism of CHFR by neuronal CDK5 /p35
- Investigation of Allosteric Inhibition Mechanisms by the Peptide P5 on the Alzheimer’s Disease (AD) Pathological Complex CDK5 -p25 through Molecular Dynamics …
- CDK5 : A Mediator of Mptp Opening
- Investigation of Allosteric Inhibition Mechanisms by the Peptide p5 on the Alzheimer’s Disease (AD) Pathological Complex CDK5 -p25 through Molecular …
- CDK5 in RNA Biology: New Clues that may Underlie Neuronal and Glial Diseases
- CDK5 promotes ventricular arrhythmogenesis through phosphorylation of N‐type calcium channels in cardiac sympathetic postganglionic neurons
- Molecular Modeling Studies of Triazolyl Thiophenes As CDK5 /P25 inhHibitors Using 3D-QSAR and Molecular Docking
- Understanding the Molecular Underpinnings of Neuronal Kinase CDK5 mediated Metabolic Vulnerabilities in Neuroendocrine Tumors
- Parkinson´ s related protein DJ-1 is involved in aberrant cell cycle re-entry through CDK5
- The role of oxidative stress in inhibiting FOXO1 through activating CDK5 in neuronal damage
- Nutrient-Dependent Association of CDK5 Regulatory Associated Protein 1-Like 1 Gene with Insulin Secretion
- Abstract LB-C04: Phosphoproteomics unravels dynamic regulation of energy sensor by CDK5 in Neuroendocrine Tumor
- STEM-15. CDK5 AND NOTCH SIGNALING CROSSTALK DRIVES SELF-RENEWAL IN GSCs
- Detailing the mechanism of CDK5 -mediated PD-L1 regulation in Medulloblastoma
- VGLUT2/CDK5 /p25 Signaling Pathway Contributed to Inflammatory Pain By CFA
- C34 INSIGHTS INTO COPD PATHOGENESIS FROM PRE-CLINICAL STUDIES: CDK5 Regulates Oxidative Stress In Cigarette Smoke Induced Apoptosis In …
- D26 OXIDATIVE STRESS AND SIGNALING IN PULMONARY VASCULAR DISEASE: Hypoxia Induces CDK5 Mediated Phosphorylation And Upregulation Of Xanthine …
- Systemic Administration of a Brain Permeable CDK5 Inhibitor Alters Neurobehavior
- S-nitrosylation of CDK5 and its Activator p35 in Neuronal Morphogenesis and Synaptic Function
- STEM-30. CDK5 INHIBITION RESOLVES PKA/cAMP-INDEPENDENT ACTIVATION OF CREB1 SIGNALING IN GLIOMA STEM CELLS
- Functional roles of cyclin-dependent kinase 5 (CDK5 ) in embryonic neurogenesis
- Erratum to: DDIS-27. TARGETING ATP DOCKING AND P35/P25 BINDING OF CDK5 IN GLIOMA STEM CELLS USING SYNTHETIC INHIBITORS
- Expressions of CDK5 and p35/p25 in the blood of patients with vascular cognitive impairment
- TNF-α increases production of reactive oxygen species through CDK5 activation in nociceptive neurons
- Changes of CDK5 expression after focal brain contusion in rats
- Effects of polydatin on learning and memory and CDK5 kinase activity in the hippocampus of rats with chronic alcoholism
- Expressions of CDK5 and p35/p25 in the blood of patients with vascular cognitive impairment
- Role of CDK5 in Activity-Induced Gene Expression and Dendrite Development
- Erratum to: STEM-19. RESISTANCE IS FUTILE: UNDERSTANDING AND TARGETING THE CDK5 -CREB1-MCL1 AXIS TO PREVENT RADIATION RESISTANCE IN …
- CDK5 downregulation enhances synaptic plasticity
- CDK5 Substrate
- Molecular Recognition of PPARγ by Kinase CDK5 /p25: Insights from a Combination of Proteinâ Protein Docking and Adaptive Biasing Force Simulations
- P5-TAT: A Novel Medicine Targeting CDK5 Over-Activation for Radiation-Induced Brain Injury
- Development of fluorescent biosensors and inhibitors to probe and target CDK5 /p25 in glioblastoma
- Phosphorylation of synapsin I by CDK5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.
- The role of CDK5 in the activation and effector function of T cells in experimental autoimmune uveitis (BA14P. 216)
- RDNA-18. TP5, A PEPTIDE INHIBITOR OF ABERRANT AND HYPERACTIVE CDK5 /p25: A NOVEL THERAPEUTIC APPROACH AGAINST GLIOBLASTOMA
- Understanding the Role of C yclin D ependent K inase 5 (CDK5 ) in Insulin Related Neurodegenerative Disease
- Endothelial CDK5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis
- Sulfurous Heterocycles Based on the Transsulfuration Metabolite Lanthionine Ketimine Are Potent, Selective Antagonists of CDK5 /p25 Signaling with Broad Potential …
- 890-P: CDK5 Regulatory Subunit-Associated Protein 1-Like 1 Promotes Adipocyte Proliferation through Transcriptional Activation of NEK8 in T2DM and Obesity
- CDK5 controls IL-2 gene expression via repression of the mSin3a-HDAC complex (IRM6P. 719)
- Effects of thin recipe of Buyang Huanwu decoction on CDK5 and apoptotic factors in an oxidative stress cell model
- The role of oxidative stress in inhibiting FOXO1 through activating CDK5 in neuronal damage
- Inhibition of roscovitine on the activity of CDK5 /p25 and phosphorylation of tau in retina of RCS rats after intravitreal injection
- CDK5 -mediated Phosphorylation of Liprinα1 is Critical for Synaptic Plasticity
- Progress in the study of new cancer target CDK5 and its inhibitors
- AAV9-mediated CDK5 inhibitory peptide (CIP) reverses pathological changes and behavioral deficits in the Alzheimer’s disease model mice
- CDK5 mediated coronin-1a phosphorylation is required for PLC-γ 1 mediated generation of inositol-1, 4, 5-trisphosphate and calcium mobilization after TCR activation …
- Immunohistochemical Study of CDK5 and Ki-67 in Cervical Precancerous Lesion and Carcinoma
- Expression pattern and diagnostic value of cyclin-dependent kinase 5 (CDK5 ) in colorectal tumors
- Roles of CDK5 -dependent phosphorylation of liprinα1 in synaptic function and plasticity
- CDK5 inhibition promotes neurogenesis while reducing self-renewal of brain tumor stem cells
- AAV-9 Mediated CDK5 Inhibitory Peptide Protects Neurons in p25 and APP/PS1 Transgenic Mouse Models
- CDK5 involves in interleukin-6 induces AR activation through phosphorylation of serine 727 Stat3 and serine 81 AR in prostate cancer cells
- Role of CDK5 in the Pathogenesis of Cough Reflex Hypersensitivty in Guinea Pigs
- Abstract A050: CDK5 disruption attenuates tumor PD-L1 expression via regulation of IFN-γ signaling components and promotes antitumor immunity
- Role of CDK5 as a Tumor Suppressor Gene in Non-Small Cell Lung Cancer
- A Wrinkle in CDK5 : A Necessary Gene for Cortical Folding
- THE EFFECT OF DECREASED ACTIVITY IN THE FORM OF SPINAL CORD LIGATION ON CDK5 EXPRESSION IN SCIATIC NERVE AND BEHAVIORAL TEST OF …
- Microtubule polarity in dendrites with CDK5 protein knock-down
- The role of p35/CDK5 regulation by miR-15/107 family in Alzheimer’s disease
- CDK5 -DA signaling has a key role in depressive like behaviours manifested at early disease stage in HD
- The role of the CDK5 pathway and NMDA receptor phosphorylation in neurodegeneration in hippocampal sclerosis
- The HU177 cryptic collagen epitope selectively regulates melanoma cell behavior by a CDK5 and PTPN12 associated mechanism
- Abstract A30: Characterizing the non-linear dependency of the CDK5 -Rb axis in non-small cell lung cancer
- Abstract A33: Biomarkers of CDK5 driven neuroendocrine tumors
- CDK5 is Associated in Cardiac Calcium Channelopathy
- Loss of CDK5 Function May Mediate Age‐Related Decline in Voluntary Physical Activity
- Ubiquitin‐dependent and‐independent degradation of p35 activation subunit of neuronal Cdk, CDK5
- A Novel Role of CDK5 in the Cell Cycle
- Data Fabrication and Data Falsification in the paper entitled” Regulation of DARPP-32 dephosphorylation at PKA and CDK5 -sites by NMDA and AMPA receptors …
- CDK5 opens the way for DLC1
- Role of CDK5 -CRMP pathway in sevoflurane-induced dendritic develop-mental disorder of neurons in prefrontal cortex of neonatal rats
- Deregulated CDK5 triggers multiple neuro-degenerative pathways in Alzheimer’s dis-ease models
- Tnf-Alpha Increases CDK5 Activity Regulating Orofacial Pain Through Phosphorylation Of Trpv1 And P2x2 Ion Channels
- CDK5 PLAYS A KEY ROLE IN PROLIFERATION, APOPTOSIS, AND IN VIVO TUMOR GROWTH OF DIFFUSE LARGE B-CELL LYMPHOMA
- Inhibition of CDK5 /p25 by TFP5 protects dopaminergic neurons in MPTP-induced mouse model of Parkinson’s disease
- CDK5 -mediated phosphorylation is required for the development and plasticity of dendritic spines
- Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and CDK5 /p25
- Effects of Treadmill Exercise and Bright Light on Expression of GABAA receptor and CDK5 in Rat Hippocampus
- Adhesion GPCR, Latrophilin-2 Induces Cardiac Differentiation Through CDK5 , Contributing to Repair After Myocardial Infarction
- IP7K is kinetically well‐equipped for cell signaling but does not regulate CDK5 activity (1013.12)
- APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice.
- The CDK inhibitor dinaciclib (SCH727965) inhibits the unfolded protein response (UPR) through a CDK1-and CDK5 -dependent mechanism
- Human Neural Progenitor Cells are Productively Infected by R5-tropic HIV-1: Opiate Interactions on Infection and Function Involve CDK5 Signaling
- CDK5 -dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development.
- Molecular Recognition of PPAR# by the Kinase CDK5 /p25: Insights from a Combination of Protein-Protein Docking and Adaptive Biasing Force Simulations
- Erratum: A numerical error in methodology section under Sequence retrieval and modeling side heading To: The role of CDK5 and GSK3B kinases in …
- ERRATUM: CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression
- CDK5 mediates activation of type I interferon pathway in PD
- Post-transcriptional regulation of BDNF and the CDK5 pathway by the neuronal RNA binding protein HuD
- To divide or differentiate?: nestin-mediated regulation of CDK5 in cell fate decisions
