REVERSAL OF OBESITY
September 23, 2022ORGANOTINS
September 23, 2022
- Phosphatidylinositol 3‐kinase
- Activation of Phosphatidylinositol 3–kinase by insulin.
- The activation of Phosphatidylinositol 3–kinase by Ras
- Association of focal adhesion kinase with its potential substrate Phosphatidylinositol 3–kinase.
- Phosphatidylinositol 3–kinase related kinases
- Phosphatidylinositol 3–kinase Encoded by Yeast VPS34 Gene Essential for Protein Sorting
- Phosphatidylinositol 3–kinase: structure and expression of the 110 kd catalytic subunit
- Wortmannin is a potent Phosphatidylinositol 3–kinase inhibitor: the role of Phosphatidylinositol 3, 4, 5-trisphosphate in neutrophil responses
- Requirement for Phosphatidylinositol–3 kinase in the prevention of apoptosis by nerve growth factor
- Ras-dependent induction of cellular responses by constitutively active Phosphatidylinositol–3 kinase
- Activation of Phosphatidylinositol–3′ kinase by Src-family kinase SH3 binding to the p85 subunit
- Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.
- A human Phosphatidylinositol 3‐kinase complex related to the yeast Vps34p‐Vps15p protein sorting system.
- Wortmannin, a potent and selective inhibitor of Phosphatidylinositol–3–kinase
- A specific inhibitor of Phosphatidylinositol 3–kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
- The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated Phosphatidylinositol 3–kinase
- Membrane localization of Phosphatidylinositol 3–kinase is sufficient to activate multiple signal-transducing kinase pathways
- The Phosphatidylinositol 3–kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.
- Cloning of a novel, ubiquitously expressed human Phosphatidylinositol 3–kinase and identification of its binding site on p85
- Inhibition of Phosphatidylinositol 3–kinase activity by association with 14-3–3 proteins in T cells.
- Phosphatidylinositol 3‘kinase: one of the effectors of Ras
- Association of p21ras with Phosphatidylinositol 3–kinase.
- Interaction of Phosphatidylinositol 3–kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors
- ErbB3 is involved in activation of Phosphatidylinositol 3–kinase by epidermal growth factor
- Phosphatidylinositol–3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells
- Activation of the Eck receptor protein tyrosine kinase stimulates Phosphatidylinositol 3–kinase activity.
- Phosphatidylinositol 3–kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation
- The inhibition of Phosphatidylinositol 3–kinase by quercetin and analogs
- Phosphatidylinositol 3–kinase inhibitors block differentiation of skeletal muscle cells
- Studies on the mechanism of Phosphatidylinositol 3–kinase inhibition by wortmannin and related analogs
- CD19 of B cells as a surrogate kinase insert region to bind Phosphatidylinositol 3–kinase
- DNA-dependent protein kinase catalytic subunit: a relative of Phosphatidylinositol 3–kinase and the ataxia telangiectasia gene product
- Involvement of Phosphatidylinositol 3–kinase in Fc gamma receptor signaling.
- The interaction of small domains between the subunits of Phosphatidylinositol 3–kinase determines enzyme activity
- Interkinase domain of kit contains the binding site for Phosphatidylinositol 3‘kinase.
- Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, Phosphatidylinositol 3‘-kinase, and protein kinase C.
- Mouse p170 is a novel Phosphatidylinositol 3–kinase containing a C2 domain
- Inhibition of the Phosphatidylinositol 3–kinase/p70S6-kinase pathway induces B16 melanoma cell differentiation
- Epidermal growth factor-dependent association of Phosphatidylinositol 3–kinase with the erbB3 gene product.
- The structure and function of p55PIK reveal a new regulatory subunit for Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase and its novel product, Phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae
- Phosphatidylinositol 3–kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein kinase Signaling Pathway (∗)
- Phosphatidylinositol (3, 4, 5) P3 interacts with SH2 domains and modulates PI 3–kinase association with tyrosine-phosphorylated proteins
- Rac GTPase interacts specifically with Phosphatidylinositol 3–kinase
- The Phosphatidylinositol 3–kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.
- Insulin stimulation of Phosphatidylinositol 3–kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.
- A novel recognition motif for Phosphatidylinositol 3–kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor
- In vitro and in vivo antitumor activity of the Phosphatidylinositol–3–kinase inhibitor, wortmannin.
- Essential role of Phosphatidylinositol 3–kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor …
- Activation of Phosphatidylinositol 3–kinase in cells expressing abl oncogene variants
- Regulation of Phosphatidylinositol 3–kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.
- EGF or PDGF receptors activate atypical PKClambda through Phosphatidylinositol 3‐kinase.
- T-cell antigen CD28 interacts with the lipid kinase Phosphatidylinositol 3–kinase by a cytoplasmic Tyr (P)-Met-Xaa-Met motif.
- Investigation of neutrophil signal transduction using a specific inhibitor of Phosphatidylinositol 3–kinase.
- Evidence for Phosphatidylinositol 3–kinase as a regulator of endocytosis via activation of Rab5.
- The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with Phosphatidylinositol 3–kinase.
- Insulin activates a p21-activated kinase in muscle cells via Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase signals activate a selective subset of Rac/Rho-dependent effector pathways
- Inhibition of histamine secretion by wortmannin through the blockade of Phosphatidylinositol 3–kinase in RBL-2H3 cells.
- Phosphatidylinositol 3–kinase binds to α-actinin through the p85 subunit
- Phospholipase C-γ1 and Phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor’s mitogenic signal
- Identification of c‐erbB‐3 binding sites for Phosphatidylinositol 3′‐kinase and SHC using an EGF receptor/c‐erbB‐3 chimera.
- Akt Is a Direct Target of the Phosphatidylinositol 3–kinase: ACTIVATION BY GROWTH FACTORS, v-src and v-Ha-ras, IN Sf9 AND MAMMALIAN CELLS
- SH2 domains of the p85 alpha subunit of Phosphatidylinositol 3–kinase regulate binding to growth factor receptors
- Role for Phosphatidylinositol 3–kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells.
- Oligodendrocytes and their precursors require Phosphatidylinositol 3–kinase signaling for survival
- Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the Phosphatidylinositol 3–kinase inhibitor, wortmannin
- Identification of Trk binding sites for SHC and Phosphatidylinositol 3‘-kinase and formation of a multimeric signaling complex.
- Phosphatidylinositol 3–kinase activity is required for early endosome fusion
- CTLA-4 binding to the lipid kinase Phosphatidylinositol 3–kinase in T cells.
- Wortmannin, a specific inhibitor of Phosphatidylinositol–3 kinase, blocks osteoclastic bone resorption
- Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of Phosphatidylinositol 3–kinase.
- Dominant missense mutations in a novel yeast protein related to mammalian Phosphatidylinositol 3–kinase and VPS34 abrogate rapamycin cytotoxicity
- Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for Phosphatidylinositol 3‘kinase.
- Molecular cloning, cDNA sequence, and chromosomal localization of the human Phosphatidylinositol 3–kinase p110α (PIK3CA) gene
- Phosphatidylinositol 3–kinase Activity Is Required at a Postendocytic Step in Platelet-derived Growth Factor Receptor Trafficking∗
- Requirement of Phosphatidylinositol–3 kinase modification for its association with p60src
- Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of Phosphatidylinositol 3–kinase.
- Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for Phosphatidylinositol 3 kinase.
- CD28 of T lymphocytes associates with Phosphatidylinositol 3–kinase
- The v-Src SH3 domain binds Phosphatidylinositol 3‘-kinase
- Signal transduction via CD40 involves activation of lyn kinase and Phosphatidylinositol–3–kinase, and phosphorylation of phospholipase C gamma 2.
- Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of Phosphatidylinositol 3–kinase.
- Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires Phosphatidylinositol 3–kinase
- Role of Phosphatidylinositol–3–kinase in insulin receptor signaling: studies with inhibitor, LY294002
- Identification of two SH3-binding motifs in the regulatory subunit of Phosphatidylinositol 3–kinase.
- Acute regulation by insulin of Phosphatidylinositol–3–kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle.
- Phosphatidylinositol 3‐kinase regulation of fluid phase endocytosis
- Phosphatidylinositol 3–kinase activation in normal human B lymphocytes.
- Wortmannin, a specific Phosphatidylinositol 3–kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells
- A Phosphatidylinositol–3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine
- Solution structure and ligand-binding site of the SH3 domain of the p85α subunit of Phosphatidylinositol 3–kinase
- Polyphosphoinositides produced by Phosphatidylinositol 3–kinase are poor substrates for phospholipases C from rat liver and bovine brain
- Stimulation of CD28 triggers an association between CD28 and Phosphatidylinositol 3–kinase in Jurkat T cells.
- A comparison of demethoxyviridin and wortmannin as inhibitors of Phosphatidylinositol 3‐kinase
- Activated Phosphatidylinositol 3–kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes
- Interactions of Cbl with Grb2 and Phosphatidylinositol 3‘-kinase in activated Jurkat cells
- Membrane Ig cross-linking regulates Phosphatidylinositol 3–kinase in B lymphocytes.
- Growth factor-dependent survival of rodent fibroblasts requires Phosphatidylinositol 3–kinase but is independent of pp70S6K activity.
- Selective CD28pYMNM mutations implicate Phosphatidylinositol 3–kinase in CD86-CD28-mediated costimulation
- Direct activation of the Phosphatidylinositol 3‘-kinase by the insulin receptor.
- Nerve growth factor promotes the activation of Phosphatidylinositol 3–kinase and its association with the trk tyrosine kinase.
- … factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or Phosphatidylinositol 3–kinase.
- Phosphorylation of middle T by pp60c-src: a switch for binding of Phosphatidylinositol 3–kinase and optimal tumorigenesis
- Activation of Src-like protein-tyrosine kinase Lyn and its association with Phosphatidylinositol 3–kinase upon B-cell antigen receptor-mediated signaling.
- Direct Association of Grb2 with the p85 Subunit of Phosphatidylinositol 3–kinase (∗)
- Overexpression of a constitutively active form of Phosphatidylinositol 3–kinase is sufficient to promote Glut 4 translocation in adipocytes
- Antagonists of Phosphatidylinositol 3–kinase block activation of several novel protein kinases in neutrophils
- Interleukin-2 triggers a novel Phosphatidylinositol 3–kinase-dependent MEK activation pathway
- GTPase-activating protein and Phosphatidylinositol 3–kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit
- Defect in skeletal muscle Phosphatidylinositol–3–kinase in obese insulin-resistant mice.
- Protein kinase C δ specifically associates with Phosphatidylinositol 3–kinase following cytokine stimulation
- p56Lck and p59Fyn regulate CD28 binding to Phosphatidylinositol 3–kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase …
- Phosphatidylinositol 3–kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits
- AtVPS34, a Phosphatidylinositol 3–kinase of Arabidopsis thaliana, is an essential protein with homology to a calcium-dependent lipid binding domain.
- Efficient coupling with Phosphatidylinositol 3–kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other …
- Requirement for Phosphatidylinositol 3–kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells
- Modulation of insulin receptor, insulin receptor substrate-1, and Phosphatidylinositol 3–kinase in liver and muscle of dexamethasone-treated rats.
- Adrenergic Receptors Activate Phosphatidylinositol 3–kinase in Human Vascular Smooth Muscle Cells: ROLE IN MITOGENESIS (∗)
- Phosphatidylinositol–3 kinase activation induced upon Fc gamma RIIIA-ligand interaction.
- Phosphatidylinositol 3–kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells.
- Insulin-stimulated Phosphatidylinositol 3–kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density …
- Regulation of Phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins: full activation requires occupancy of Both SH2 domains in the 85-kDa regulatory …
- Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a Phosphatidylinositol 3–kinase in vesicular transport to lysosomes.
- Phosphatidylinositol 3–kinase associates, via its Src homology 2 domains, with the activated erythropoietin receptor
- Phosphatidylinositol 3–kinase mediates the inhibitory effect of epidermal growth factor on calcium-dependent chloride secretion
- The Phosphatidylinositol 3–kinase Inhibitor Wortmannin Sensitizes Murine Fibroblasts and Human Tumor Cells to Radiation and Blocks Induction of p53 following …
- 1-Phosphatidylinositol 3–kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.
- The inability of Phosphatidylinositol 3–kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated …
- Insulin stimulation of Phosphatidylinositol 3–kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation.
- Overexpression of catalytic subunit p110α of Phosphatidylinositol 3–kinase increases glucose transport activity with translocation of glucose transporters in …
- Platelet-derived growth factor-induced Phosphatidylinositol 3–kinase activation mediates actin rearrangements in fibroblasts
- Regulated coupling of the Neu receptor to Phosphatidylinositol 3‘-kinase and its release by oncogenic activation.
- Requirement for Phosphatidylinositol 3‘-kinase to protect hemopoietic progenitors against apoptosis depends upon the extracellular survival factor.
- The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the Phosphatidylinositol–3‘kinase …
- Internalization of activated platelet-derived growth factor receptor-Phosphatidylinositol–3‘kinase complexes: potential interactions with the microtubule cytoskeleton
- A regulatory role for cAMP in Phosphatidylinositol 3–kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine …
- Phosphatidylinositol 3–kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.
- Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and Phosphatidylinositol 3–kinase in human monocytes.
- Two types of Phosphatidylinositol 3–kinase from bovine thymus. Monomer and heterodimer form
- Multiple roles of Phosphatidylinositol 3–kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells
- Stimulation of Phosphatidylinositol 3‘-kinase association with foca adhesion kinase by platelet-derived growth factor.
- Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and Phosphatidylinositol 3–kinase activity are decreased in intact skeletal muscle strips …
- Association of Phosphatidylinositol 3–kinase with SHC in chronic myelogeneous leukemia cells.
- Both Phosphatidylinositol 3–kinase and Phosphatidylinositol 4-kinase products are increased by antigen receptor signaling in B cells.
- Profilin and gelsolin stimulate Phosphatidylinositol 3–kinase activity
- Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding Phosphatidylinositol 3–kinase
- … Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells: WORTMANNIN IS NOT A SPECIFIC INHIBITOR OF Phosphatidylinositol 3–kinase (∗ …
- Insulin and insulinomimetic agents induce activation of Phosphatidylinositol 3‘-kinase upon its association with pp185 (IRS-1) in intact rat livers.
- Multiple cytokines activate Phosphatidylinositol 3–kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.
- IRS-1 activates Phosphatidylinositol 3‘-kinase by associating with src homology 2 domains of p85.
- Requirement of Phosphatidylinositol–3 kinase for epithelial cell migration activated by human macrophage stimulating protein.
- Effect of aging on insulin receptor, insulin receptor substrate-1, and Phosphatidylinositol 3–kinase in liver and muscle of rats
- Biased combinatorial libraries: novel ligands for the SH3 domain of Phosphatidylinositol 3–kinase
- IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the Phosphatidylinositol 3‘-kinase
- Phosphatidylinositol 3–kinase Recruitment by p185erbB-2 and erbB-3 Is Potently Induced by neu Differentiation Factor/Heregulin during Mitogenesis and Is …
- Genetic analysis of a Phosphatidylinositol 3–kinase SH2 domain reveals determinants of specificity
- Interleukin-10 stimulation of Phosphatidylinositol 3–kinase and p70 S6 kinase is required for the proliferative but not the antiinflammatory effects of the cytokine
- Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3–kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3 (∗)
- Phosphatidylinositol–3–kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution.
- A Phosphatidylinositol 3–kinase is induced during soybean nodule organogenesis and is associated with membrane proliferation.
- A role for Phosphatidylinositol 3–kinase in the regulation of beta 1 integrin activity by the CD2 antigen.
- Association of Phosphatidylinositol 3–kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation.
- Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-kinase (∗)
- Platelet-derived growth factor-dependent activation of Phosphatidylinositol 3–kinase is regulated by receptor binding of SH2-domain-containing proteins which …
- Activation of Mitogen-activated Protein kinase and Phosphatidylinositol 3′-kinase Is Not Sufficient for the Hormonal Stimulation of Glucose Uptake …
- … through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/Phosphatidylinositol 3–kinase complex in human B cell …
- Novel functions of Phosphatidylinositol 3–kinase in terminally differentiated cells
- Phosphatidylinositol 3–kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding
- Activation of the zeta isozyme of protein kinase C by Phosphatidylinositol 3, 4, 5-trisphosphate.
- … Mitogen-activated Protein kinase Activation by Platelet-activating Factor through a Mechanism Independent of p85/p110-type Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3–kinase and p70 s6 kinase participate in the regulation of protein turnover in skeletal muscle by insulin and insulin-like growth factor I
- Specific association of the β isoform of the p85 subunit of Phosphatidylinositol–3 kinase with the proto-oncogene c-cbl
- Insulin-mediated Targeting of Phosphatidylinositol 3–kinase to GLUT4-containing Vesicles (∗)
- HGF-mediated chemotaxis and tubulogenesis require activation of the Phosphatidylinositol 3–kinase
- CD28-mediated costimulation in the absence of Phosphatidylinositol 3–kinase association and activation
- Phosphatidylinositol 3–kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription
- Expression and characterization of the p85 subunit of the Phosphatidylinositol 3–kinase complex and a related p85β protein by using the baculovirus expression …
- Involvement of Phosphatidylinositol 3–kinase in the activation of extracellular signal-regulated kinase by PDGF in hepatic stellate cells
- Two Distinct Intracytoplasmic Regions of the T-cell Adhesion Molecule CD28 Participate in Phosphatidylinositol 3–kinase Association (∗)
- Receptor tyrosine kinase stimulates cell-matrix adhesion by Phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways
- CD28 delivers costimulatory signals independently of its association with Phosphatidylinositol 3–kinase.
- Thrombin-dependent association of Phosphatidylinositol–3 kinase with p60c-src and p59fyn in human platelets
- Polyoma virus middle T antigen-pp60c-src complex associates with purified Phosphatidylinositol 3–kinase in vitro.
- ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of Phosphatidylinositol 3–kinase and Ras/MAPK pathway.
- Brush Border Phosphatidylinositol 3–kinase Mediates Epidermal Growth Factor Stimulation of Intestinal NaCl Absorption and Na+/H+ Exchange (∗)
- Interaction of the Flt-1 Tyrosine kinase Receptor with the p85 Subunit of Phosphatidylinositol 3–kinase: MAPPING OF A NOVEL SITE INVOLVED IN BINDING …
- Activation of Phosphatidylinositol–3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity
- … receptor activation of Phosphatidylinositol 3–kinase. von Willebrand factor stimulates the cytoskeletal association and activation of Phosphatidylinositol 3–kinase and …
- Fc receptor stimulation of Phosphatidylinositol 3–kinase in natural killer cells is associated with protein kinase C-independent granule release and cell-mediated …
- The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of Phosphatidylinositol 3–kinase to phosphorylated platelet-derived …
- Interleukin‐7 induces the association of Phosphatidylinositol 3‐kinase with the α chain of the interleukin‐7 receptor
- A biosensor approach to probe the structure and function of the p85 alpha subunit of the Phosphatidylinositol 3–kinase complex
- ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and Phosphatidylinositol 3–kinase activation in cultured …
- Activation of Phosphatidylinositol 3–kinase by epidermal growth factor, basic fibroblast growth factor, and nerve growth factor in PC12 pheochromocytoma cells.
- Insulin Stimulates Phosphatidylinositol‐3‐kinase activity in rat adipocytes
- Wortmannin binds specifically to 1-Phosphatidylinositol 3–kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil …
- Erythropoietin-dependent association of Phosphatidylinositol 3–kinase with tyrosine-phosphorylated erythropoietin receptor.
- The colony stimulating factor-1 receptor associates with and activates Phosphatidylinositol–3 kinase
- Phosphatidylinositol–3 kinase and growth regulation
- Divergent regulation of Phosphatidylinositol 3–kinase P85 alpha and P85 beta isoforms upon T cell activation
- Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of Phosphatidylinositol 3–kinase in muscle and brain
- Tumor Necrosis Factor Promotes Phosphorylation and Binding of Insulin Receptor Substrate 1 to Phosphatidylinositol 3–kinase in 3T3-L1 Adipocytes (∗)
- A region of the 85-kilodalton (kDa) subunit of Phosphatidylinositol 3–kinase binds the 110-kDa catalytic subunit in vivo
- Phosphatidylinositol 3–kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells
- Functional association of CD7 with Phosphatidylinositol 3–kinase: interaction via a YEDM motif
- Roles of 1-Phosphatidylinositol 3–kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells
- … within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated Phosphatidylinositol–3 kinase activity without affecting …
- Nuclear translocation of Phosphatidylinositol 3–kinase in rat pheochromocytoma PC 12 cells after treatment with nerve growth factor.
- Association of phosphorylated insulin-like growth factor-I receptor with the SH2 domains of Phosphatidylinositol 3–kinase p85.
- Phosphatidylinositol 3–kinase activity is required for hepatocyte growth factor-induced mitogenic signals in epithelial cells
- The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates Phosphatidylinositol 3–kinase in vitro.
- An inhibitory role for Phosphatidylinositol 3–kinase in insulin secretion from pancreatic B cell line MIN6
- Rapid turnover of Phosphatidylinositol 3-phosphate in the green alga Chlamydomonas eugametos: signs of a phosphatidylinositide 3–kinase signalling pathway in …
- Ionizing Radiation Stimulates a Grb2-mediated Association of the Stress-activated Protein kinase with Phosphatidylinositol 3–kinase (∗)
- Essential role of Phosphatidylinositol 3‐kinase in insulin‐induced activation and phosphorylation of the cGMP‐inhibited cAMP phosphodiesterase in rat adipocytes …
- Inhibition of Phosphatidylinositol 3‐kinase blocks T cell antigen receptor/CD3‐induced activation of the mitogen‐activated kinase Erk2
- Insulin receptor substrate-1 mediates Phosphatidylinositol 3‘-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.
- Purification and characterization of a Phosphatidylinositol 3–kinase complex from bovine brain by using phosphopeptide affinity columns
- Association of the p85 regulatory subunit of Phosphatidylinositol 3–kinase with an essential erythropoietin receptor subdomain
- The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with Phosphatidylinositol 3‘-kinase
- A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3–kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85α Gene (∗)
- The Phosphatidylinositol 3–kinase inhibitor wortmannin blocks mast cell exocytosis but not IL-6 production.
- In vivo binding properties of SH2 domains from GTPase-activating protein and Phosphatidylinositol 3–kinase
- … . Rapid induction of tyrosine phosphorylation, activation of syk tyrosine kinase, and phosphorylation of phospholipase C-gamma and Phosphatidylinositol 3–kinase.
- Wortmannin, a potent inhibitor of Phosphatidylinositol 3–kinase, inhibits osteoclastic bone resorption in vitro
- Structure and function of Phosphatidylinositol 3–kinase: a potential second messenger system involved in growth control
- Role of Phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: Phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in …
- Biochemical and pharmacological studies with KT7692 and LY294002 on the role of Phosphatidylinositol 3–kinase in FcεRI-mediated signal transduction
- The SH3 domain of p56lck is involved in binding to Phosphatidylinositol 3‘-kinase from T lymphocytes
- Activation of Phosphatidylinositol 3–kinase by prolactin in Nb2 cells
- Selective inhibition of p70 S6 kinase activation by Phosphatidylinositol 3‐kinase inhibitors
- Expression of Dominant Negative Mutant SHPTP2 Attenuates Phosphatidylinositol 3′-kinase Activity via Modulation of Phosphorylation of Insulin Receptor …
- Src-homology 3 domain of protein kinase p59fyn mediates binding to Phosphatidylinositol 3–kinase in T cells.
- Effect of the Activation of Phosphatidylinositol 3–kinase by a Thiophosphotyrosine Peptide on Glucose Transport in 3T3-L1 Adipocytes (∗)
- A mutational analysis of Phosphatidylinositol–3–kinase activation by human colony-stimulating factor-1 receptor
- Phosphatidylinositol–3 kinase is activated in v-src, v-yes, and v-fps transformed chicken embryo fibroblasts.
- Insulin-mediated inhibition of apolipoprotein B secretion requires an intracellular trafficking event and Phosphatidylinositol 3–kinase activation: studies with brefeldin A …
- Phosphatidylinositol 3–kinase, but Not p70/p85 Ribosomal S6 Protein kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase …
- Activation of Phosphatidylinositol‐3‐kinase in Jurkat T cells depends on the presence of the p56lck tyrosine kinase
- Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by Phosphatidylinositol 3–kinase.
- Inhibition of the signalling enzyme Phosphatidylinositol–3–kinase by antitumor ether lipid analogues
- Formation of c-Cbl· Phosphatidylinositol 3–kinase Complexes on Lymphocyte Membranes by a p56lck-independent Mechanism
- Activation of protein kinase C by Phosphatidylinositol 3, 4, 5-trisphosphate
- Activation of Phosphatidylinositol–3 kinase by ligation of the interleukin-7 receptor on human thymocytes.
- T Cell Activation-dependent Association between the p85 Subunit of the Phosphatidylinositol 3–kinase and Grb2/Phospholipase C-γ1-binding Phosphotyrosyl …
- Phosphatidylinositol 3–kinase-independent signal transduction pathway for platelet-derived growth factor-induced chemotaxis
- Microinjection of the SH2 domain of the 85-kilodalton subunit of Phosphatidylinositol 3–kinase inhibits insulin-induced DNA synthesis and c-fos expression
- Phosphatidylinositol 3–kinase activity is important for progesterone-induced Xenopus oocyte maturation
- Phosphatidylinositol 3–kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown
- Interleukin-2 receptor regulates activation of Phosphatidylinositol 3–kinase
- … interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and Phosphatidylinositol 3–kinase
- The Src-family kinase, Fyn, regulates the activation of Phosphatidylinositol 3–kinase in an interleukin 2-responsive T cell line.
- Insulin like growth factor-I induces limited association of Phosphatidylinositol 3–kinase to its receptor.
- Requirement for Phosphatidylinositol 3′-kinase Activity in Platelet-derived Growth Factor-stimulated Tyrosine Phosphorylation of p125 Focal Adhesion …
- PDGF-mediated activation of Phosphatidylinositol 3 kinase in human mesangial cells
- Direct association of p110 beta Phosphatidylinositol 3–kinase with p85 is mediated by an N-terminal fragment of p110 beta
- JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of Phosphatidylinositol–3‘kinase
- Activation of Phosphatidylinositol–3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains
- … Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3–kinase …
- Signal transduction in neutrophil activation Phosphatidylinositol 3‐kinase is stimulated without tyrosine phosphorylation
- Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of Phosphatidylinositol 3–kinase
- Different Effects of Insulin and Platelet‐Derived Growth Factor on Phosphatidylinositol 3‐kinase at the Subcellular Level in 3T3‐L1 Adipocytes: A Possible Explanation …
- … translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and Phosphatidylinositol 3–kinase
- A multiwell assay for inhibitors of Phosphatidylinositol–3–kinase and the identification of natural product inhibitors.
- Physiologic Levels of β‐Amyloid Activate Phosphatidylinositol 3‐kinase with the Involvement of Tyrosine Phosphorylation
- Regulation of Phosphatidylinositol 3–kinase by insulin in rat skeletal muscle
- … p120: demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and Phosphatidylinositol 3–kinase
- Evidence for a role of Phosphatidylinositol 3–kinase in the regulation of glucose transport in Xenopus oocytes.
- … Stimulates the Tyrosine Phosphorylation of the Insulin Receptor Substrate-1 and Its Association with Phosphatidylinositol 3–kinase in Primary Adipocytes (∗)
- Modification of the 85-kilodalton subunit of Phosphatidylinositol–3 kinase in platelet-derived growth factor-stimulated cells
- Regulation of insulin receptor, insulin receptor substrate-1 and Phosphatidylinositol 3–kinase in 3T3-F442A adipocytes. Effects of differentiation, insulin, and …
- IL-2 binding activates a tyrosine-phosphorylated Phosphatidylinositol–3–kinase.
- Phosphatidylinositol 3–kinase and the actin network are not required for the stimulation of glucose transport caused by mitochondrial uncoupling: comparison with …
- Extracellular human immunodeficiency virus type-1 Tat protein activates Phosphatidylinositol 3–kinase in PC12 neuronal cells
- Evidence that protein tyrosine kinase p56-Lck regulates the activity of Phosphatidylinositol–3‘-kinase in interleukin-2-dependent T-cells.
- Association of IRS-1 with the insulin receptor and the Phosphatidylinositol 3‘-kinase. Formation of binary and ternary signaling complexes in intact cells.
- Differential effects of okadaic acid on insulin-stimulated glucose and amino acid uptake and Phosphatidylinositol 3–kinase activity
- … a mitogen-activated protein kinase (ERK2) by the 5-hydroxytryptamine1A receptor is sensitive not only to inhibitors of Phosphatidylinositol 3–kinase, but to an …
- Association of Phosphatidylinositol 3–kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts
- SH2-dependent association of Phosphatidylinositol 3‘-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain.
- Association between Phosphatidylinositol–3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages
- Phosphatidylinositol–3–kinase activity is required for the anti-Ig-mediated growth inhibition of a human B-lymphoma cell line
- Role of p85 subunit of Phosphatidylinositol–3–kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein.
- Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of Phosphatidylinositol–3–kinase
- Association of activated Phosphatidylinositol 3–kinase with p120cbl in antigen receptor-ligated B cells
- The alpha-type 85-kDa subunit of Phosphatidylinositol 3–kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor.
- Inhibition of Phosphatidylinositol–3′-kinase Prevents Induction of Endotoxin Tolerancein Vitro
- Synthesis and in Vitro Evaluation of New Wortmannin Esters: Potent Inhibitors of Phosphatidylinositol 3–kinase
- Schizosaccharomyces pombe Vps34p, a Phosphatidylinositol-specific PI 3–kinase essential for normal cell growth and vacuole morphology
- Effects of growth factors on Phosphatidylinositol‐3 kinase in astroglial cells
- … -like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with Phosphatidylinositol–3 kinase in human thymocytes.
- Phosphatidylinositol 3′‐kinase associates with p145c‐kit as part of a cell type characteristic multimeric signalling complex.
- The Phosphatidylinositol 3–kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C …
- Characterization of the bovine brain cytosolic Phosphatidylinositol 3–kinase complex
- Phosphatidylinositol 3–kinase activity is required for the activation process of focal adhesion kinase by platelet-derived growth factor
- Structure of a specific peptide complex of the carboxy‐terminal SH2 domain from the p85 alpha subunit of Phosphatidylinositol 3‐kinase.
- … characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and Phosphatidylinositol 3–kinase.
- Specific activity of Phosphatidylinositol 3–kinase is increased by insulin stimulation
- Mutations in the juxtamembrane region of the insulin receptor impair activation of Phosphatidylinositol 3–kinase by insulin
- CD38-mediated growth suppression of B-cell progenitors requires activation of Phosphatidylinositol 3–kinase and involves its association with the protein product of …
- Signal transduction by the hepatocyte growth factor receptor, c-met. Activation of the Phosphatidylinositol 3–kinase.
- Transformation-defective mutants of polyomavirus middle T antigen associate with Phosphatidylinositol 3–kinase (PI 3–kinase) but are unable to maintain wild-type …
- Structural features of the colony‐stimulating factor 1 receptor that affect its association with Phosphatidylinositol 3‐kinase.
- Activation of Na+/H+ exchange by platelet-derived growth factor involves Phosphatidylinositol 3‘-kinase and phospholipase C gamma.
- Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the Phosphatidylinositol 3–kinase inhibitor wortmannin
- Phosphatidylinositol–3 kinase in fission yeast: a possible role in stress responses
- Insulin-dependent formation of a complex containing an 85-kDa subunit of Phosphatidylinositol 3–kinase and tyrosine-phosphorylated insulin receptor …
- Regulation by insulin of Phosphatidylinositol 3‘-kinase bound to alpha-and beta-isoforms of p85 regulatory subunit.
- Herbimycin A inhibits the association of p60v-src with the cytoskeletal structure and with Phosphatidylinositol 3‘kinase.
- Novel quinone antiproliferative inhibitors of Phosphatidylinositol–3–kinase.
- … and insulin-like growth factor-I actions in the bovine luteal cell: regulation of receptor tyrosine kinase activity, Phosphatidylinositol–3–kinase, and deoxyribonucleic acid …
- Oncostatin M activates Phosphatidylinositol–3–kinase in Kaposi’s sarcoma cells.
- Interleukin 2-and polyomavirus middle T antigen-induced modification of Phosphatidylinositol 3–kinase activity in activated T lymphocytes
- Erythropoietin induces the association of Phosphatidylinositol 3′‐kinase with a tyrosine‐phosphorylated protein complex containing the erythropoietin receptor
- Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by Phosphatidylinositol 3–kinase and inhibited by cyclic AMP
- In vitro association of Phosphatidylinositol 3–kinase activity with the activated insulin receptor tyrosine kinase.
- Phosphatidylinositol 3‐kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin
- Effect of epidermal growth factor on Phosphatidylinositol 3–kinase activity in rabbit corneal epithelial cells
- Insulin-stimulated Phosphatidylinositol 3–kinase activity and 2-deoxy-D-glucose uptake in rat skeletal muscles
- Activation and nuclear translocation of mitogen-activated protein kinases by polyomavirus middle-T or serum depend on Phosphatidylinositol 3–kinase
- Localization of mRNA for Phosphatidylinositol 3–kinase in brain of developing and mature rats
- Phosphatidylinositol 3–kinase inhibitor, wortmannin, inhibits 5-hydroxytryptamine-mediated potentiation of platelet aggregation induced by epinephrine.
- The human gene encoding Phosphatidylinositol–3 kinase associated p85α is at chromosome region 5q12–13
- Role of p85 subunit of Phosphatidylinositol–3–kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1.
- An 11-Amino Acid Sequence from c-met Initiates Epithelial Chemotaxis via Phosphatidylinositol 3–kinase and Phospholipase C (∗)
- Specific binding of Fyn and Phosphatidylinositol 3‐kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains
- … Interfere with Chemoattractant-induced Respiratory Burst in Neutrophils as a Result of the Inhibition of Phosphatidylinositol 3–kinase Rather than Receptor …
- Differential effects of spermine on Phosphatidylinositol 3–kinase and Phosphatidylinositol phosphate 5-kinase
- Angiotensin II induces tyrosine phosphorylation of insulin receptor substrate 1 and its association with Phosphatidylinositol 3–kinase in rat heart
- Cooperation of Src homology domains in the regulated binding of Phosphatidylinositol 3–kinase: a role for the Src homology 2 domain
- Evidence for a role of Phosphatidylinositol 3–kinase in IL-4-induced germline Cϵ transcription
- Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of Phosphatidylinositol 3–kinase activity as well as association of p85 subunit to tyrosine …
- Hepatocyte growth factor-induced proliferation of primary hepatocytes is mediated by activation of Phosphatidylinositol 3–kinase
- Platelet-derived growth factor activates membrane-associated Phosphatidylinositol 3–kinase and mediates its translocation from the cytosol. Detection of …
- Mutations in the SH3 domain of the src oncogene which decrease association of Phosphatidylinositol 3‘-kinase activity with pp60v-src and alter cellular morphology
- T cell receptor-associated alpha-Phosphatidylinositol 3–kinase becomes activated by T cell receptor cross-linking and requires pp56lck.
- … of the free catalytic p110 alpha and the complexed heterodimeric p110 alpha. p85 alpha forms of the mammalian Phosphatidylinositol 3–kinase.
- Translocation, Activation and Association of Protein‐tyrosine kinase (p72syk) with Phosphatidylinositol 3‐kinase are Early Events During Platelet Activation
- Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of Phosphatidylinositol 3–kinase in insulin-induced Xenopus oocyte …
- … colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and Phosphatidylinositol 3‘-kinase.
- Thrombin-stimulated immunoprecipitation of Phosphatidylinositol 3–kinase from human platelets.
- Regulation of phosphoinositide kinases in T cells. Evidence that Phosphatidylinositol 3–kinase is not a substrate for T cell antigen receptor-regulated tyrosine …
- Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate Phosphatidylinositol 3–kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 …
- Enhanced gene expression for Phosphatidylinositol 3–kinase in the hypoglossal motoneurons following axonal crush
- Phosphatidylinositol 3–kinase
- Agonist-induced association of the p21rasGTPase-activating protein with Phosphatidylinositol 3–kinase
- Insulin induces a change in Rab5 subcellular localization in adipocytes independently of Phosphatidylinositol 3–kinase activation
- Cytoplasmic and nuclear localization sites of Phosphatidylinositol 3–kinase in human osteosarcoma sensitive and multidrug-resistant Saos-2 cells
- Functional interactions of Phosphatidylinositol 3–kinase with GTPase-activating protein in 3T3-L1 adipocytes
- Phosphatidylinositol–3′ kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase
- … a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and Phosphatidylinositol–3 kinase, activation of c …
- Potent activation of Phosphatidylinositol 3‘-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for …
- The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with Phosphatidylinositol 3–kinase.
- Specific association of Phosphatidylinositol 3‐kinase with the protooncogene product Cbl in Fcγ receptor signaling
- Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and Phosphatidylinositol 3–kinase in Fao hepatoma cells
- Phosphatidylinositol 3–kinase activity in murine erythroleukemia cells during DMSO-induced differentiation
- Activation of Src-family protein tyrosine kinases and Phosphatidylinositol 3–kinase in 3T3-L1 mouse preadipocytes by interleukin-11.
- The level of insulin receptor tyrosine kinase activity modulates the activities of Phosphatidylinositol 3–kinase, microtubule-associated protein, and S6 kinases.
- Wortmannin inhibits insulin secretion in pancreatic islets and β-TC3 cells independent of its inhibition of Phosphatidylinositol 3–kinase
- … derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through Phosphatidylinositol 3–kinase binding sites on …
- Induction of activator protein (AP)-1 and nuclear factor-kappaB by CD28 stimulation involves both Phosphatidylinositol 3–kinase and acidic sphingomyelinase signals.
- CD28-mediated up-regulation of beta 1-integrin adhesion involves Phosphatidylinositol 3–kinase.
- The HIV-1 Nef Protein Interferes with Phosphatidylinositol 3–kinase Activation 1 (∗)
- Monocyte Colony-stimulating Factor Stimulates Binding of Phosphatidylinositol 3–kinase to Grb2· Sos Complexes in Human Monocytes
- The protein product of the proto-oncogene c-cbl forms a complex with Phosphatidylinositol 3–kinase p85 and CD19 in anti-IgM-stimulated human B-lymphoma …
- Potentiation of insulin stimulation of Phosphatidylinositol 3–kinase by thiazolidinedione-derived antidiabetic agents in Chinese hamster ovary cells expressing human …
- Modulation of the substrate specificity of the mammalian Phosphatidylinositol 3–kinase by cholesterol sulfate and sulfatide
- Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of Phosphatidylinositol 3–kinase
- Involvement of Phosphatidylinositol 3–kinase in stimulation of glucose transport by growth factors in 3T3-L1 adipocytes.
- 17β-hydroxywortmannin: A potent inhibitor of bone resorption and Phosphatidylinositol–3–kinase
- Activation of Phosphatidylinositol–3–kinase by platelet-derived growth factor and insulin-like growth factor-1 is inhibited by a transmembrane phosphotyrosine …
- CD28-mediated cytotoxicity by the human leukemic NK cell line YT involves tyrosine phosphorylation, activation of Phosphatidylinositol 3–kinase, and protein kinase C …
- Association of Phosphatidylinositol 3 kinase to protein kinase C ζ during interleukin‐2 stimulation
- Interaction of the molecular weight 85K regulatory subunit of the Phosphatidylinositol 3–kinase with the insulin receptor and the insulin-like growth factor-1 (IGF-I) …
- A tyrosine kinase signaling pathway accounts for the majority of Phosphatidylinositol 3, 4, 5-trisphosphate formation in chemoattractant-stimulated human …
- Phorbol ester treatment inhibits Phosphatidylinositol 3–kinase activation by, and association with, CD28, a T-lymphocyte surface receptor.
- Chromosomal localization of human p85 alpha, a subunit of Phosphatidylinositol 3–kinase, and its homologue p85 beta.
- Phosphatidylinositol 3′-kinase, but not p70 ribosomal S6 kinase, is involved in membrane protein recycling: wortmannin inhibits glucose transport and …
- Gastrin stimulates tyrosine phosphorylation of insulin receptor substrate 1 and its association with Grb2 and the Phosphatidylinositol 3–kinase
- Identification of amino acid residues required for a specific interaction between Src-tyrosine kinase and proline-rich region of Phosphatidylinositol–3′ kinase
- Studies with wortmannin suggest a role for Phosphatidylinositol 3–kinase in the activation of glycogen synthase and mitogen-activated protein kinase by insulin in rat …
- Insulin treatment stimulates the tyrosine phosphorylation of the alpha-type 85-kDa subunit of Phosphatidylinositol 3–kinase in vivo.
- NMR Analysis of Interactions of a Phosphatidylinositol 3 ‘-kinase SH2 Domain with Phosphotyrosine Peptides Reveals Interdependence of Major Binding Sites
- Endotoxin tolerance alters phospholipase C-γ1 and Phosphatidylinositol–3′-kinase expression in peritoneal macrophages
- … cytoplasmic domain of the interleukin-2 receptor beta chain is essential for interleukin-2-dependent tyrosine protein kinase and Phosphatidylinositol–3–kinase …
- Phosphatidylinositol–3–kinase is a non-tyrosine phosphorylated member of the insulin receptor signalling complex
- Activation of Phosphatidylinositol–3–kinase by insulin is mediated by both A and B human insulin receptor types
- CD28 co-stimulatory regimes differ in their dependence on Phosphatidylinositol 3–kinase: common co-signals induced by CD80 and CD86
- Naturally occurring ether‐linked phosphatidylcholine activates Phosphatidylinositol 3‐kinase and stimulates cell growth
- … colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with Phosphatidylinositol 3–kinase, or induction of c …
- Interleukin-4 induces association of the c-fes proto-oncogene product with Phosphatidylinositol–3 kinase
- Cyclic peptide inhibitors of Phosphatidylinositol 3–kinase p85 SH2 domain binding
- Studies of partially transforming polyomavirus mutants establish a role for Phosphatidylinositol 3–kinase in activation of pp70 S6 kinase
- Lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a Phosphatidylinositol 3′-kinase with distinct properties
- Phosphatidylinositol 3-OH kinase activity is not required for activation of mitogen-activated protein kinase by cytokines
- Growth factor-regulated Phosphatidylinositol–3–kinase in astrocytes. Involvement of pp60c-Src.
- Selective inhibition of Phosphatidylinositol 3–kinase by phosphatidic acid and related lipids
- Evidence of the Involvement of Phosphatidylinositol 3–kinase in the Migration, Actin Stress Fiber Formation, and αvβ3-Integrin–Mediated Adherence of Human …
- The effects of wortmannin, a potent inhibitor of Phosphatidylinositol 3–kinase, on insulin-stimulated glucose transport, GLUT4 translocation, antilipolysis, and DNA …
- Phosphatidylinositol 3–kinase binding to polyoma virus middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 …
- Phosphatidylinositol 3–kinase participates in p56 (lck)/CD4-dependent down-regulation of LFA-1-mediated T cell adhesion.
- Wortmannin, a specific inhibitor of Phosphatidylinositol–3–kinase, inhibits erythropoietin-induced erythroid differentiation of K562 cells.
- Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of Phosphatidylinositol 3–kinase to the IL-4 receptor in a mouse T cell …
- Mammalian Phosphatidylinositol 3′‐kinase induces a lethal phenotype on expression in Schizosaccharomyces pombe; comparison with the VPS34 gene product
- A role for Phosphatidylinositol 3–kinase in generating T cell help for B cell growth and differentiation.
- Insulin Stimulates Phosphatidylinositol 3‐kinase Activity in Rat Neuronal Primary Cultures
- Comparison of CD28‐B7. 1 and B7. 2 functional interaction in resting human T cells: Phosphatidylinositol 3‐kinase association to CD28 and cytokine production
- Tyrosine 508 of the 85-kilodalton subunit of Phosphatidylinositol 3–kinase is phosphorylated by the platelet-derived growth factor receptor
- Interleukin 7 receptor mediates the activation of Phosphatidylinositol–3 kinase in human B-cell precursors
- Association of Phosphatidylinositol 3‐kinase with the photo‐oncogene product Cbl upon CD38 ligation by a specific monoclonal antibody in THP‐1 cells
- Regulation of CD4-p561ck-associated Phosphatidylinositol 3–kinase (PI 3–kinase) and Phosphatidylinositol 4-kinase (PI 4-kinase)
- … in downstream signaling pathways of p185BCR-ABL in Ph+ ALL involve GTPase-activating protein, phospholipase C-gamma 1, and Phosphatidylinositol 3‘-kinase.
- … That Signals DNA Synthesis in NIH 3T3 Cells Specifically Binds a Complex of Src and Janus Family Tyrosine kinases and Phosphatidylinositol 3–kinase (∗)
- Anti-phosphotyrosine immunoprecipitation of Phosphatidylinositol 3′ kinase activity in different cell types after exposure to epidermal growth factor
- … B cell antigen receptor-related structure of pre-B cell lines induces tyrosine phosphorylation of p85 and p110 subunits and activation of Phosphatidylinositol 3–kinase
- The Gene That Encodes the Phosphatidylinositol–3 kinase Regulatory Subunit (p85α) Maps to Chromosome 13 in the Mouse
- The catalytic subunit of Phosphatidylinositol 3–kinase is a substrate for the activated platelet-derived growth factor receptor, but not for middle-T antigen-pp60c-src …
- Phosphatidylinositol 3 kinase activity is not essential for B7-1-mediated costimulation of proliferation or development of cytotoxicity in murine T cells.
- Effects of phorbol esters on insulin‐induced activation of Phosphatidylinositol 3‐kinase, glucose transport, and glycogen synthase in rat adipocytes
- The E5 gene product of rhesus papillomavirus is an activator of endogenous Ras and Phosphatidylinositol–3′-kinase in NIH 3T3 cells
- … by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and Phosphatidylinositol 3–kinase
- … site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate Phosphatidylinositol–3 kinase but show differential …
- Insulin-like growth factor-1 stimulation of cells induces formation of complexes containing Phosphatidylinositol–3–kinase, guanosine triphosphatase-activating protein …
- Phosphatidylinositol 3–kinase
- Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and Phosphatidylinositol-specific PI 3–kinase …
- Wortmannin-mediated inhibition of Phosphatidylinositol 3–kinase activity triggers apoptosis in normal and neoplastic B lymphocytes which are in cell cycle
- … in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and Phosphatidylinositol 3–kinase …
- … exerts a full insulin-like effect on glucose transport and glucose transporter 4 translocation in human adipocytes: evidence for a Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3–kinase: inhibition of intrinsic protein-serine kinase activity by phosphoinositides, and of lipid kinase activity by Mn2+
- Alternative binding of p56lck and Phosphatidylinositol 3–kinase in T cells by sulfhydryl oxidation: implication of aberrant signaling due to oxidative stress in T …
- Effect of IGF-I on Phosphatidylinositol 3–kinase in soleus muscle of lean and insulin-resistant obese mice
- Activation of Phosphatidylinositol 3–kinase and Phosphatidylinositol 4-kinase during rat parotid acinar cell proliferation
- A product of Phosphatidylinositol–3 kinase is elevated in dividing HT29 colonic epithelial cells
- Phosphorylation in vitro of the 85 kDa subunit of Phosphatidylinositol 3–kinase and its possible activation by insulin receptor tyrosine kinase
- Structure-activity studies of phosphorylated peptide inhibitors of the association of Phosphatidylinositol 3–kinase with PDGF-β receptor
- Mitogenic inhibition by phorbol esters is associated with decreased Phosphatidylinositol–3 kinase activation
- Structure of 85 kDa subunit of human Phosphatidylinositol 3‐kinase analyzed by using monoclonal antibodies
- Activation of Phosphatidylinositol 3–kinase by concanavalin A through dual signaling pathways, G-protein-coupled and phosphotyrosine-related, and an essential role …
- Rapid and efficient purification of Src homology 2 domain-containing proteins: Fyn, Csk and Phosphatidylinositol 3–kinase p85
- Activation of Akt by nerve growth factor via Phosphatidylinositol–3 kinase in PC12 pheochromocytoma cells
- SH3 domain-mediated dimerization of an n-terminal fragment of the Phosphatidylinositol 3–kinase p85 subunit
- EFFECT OF LOVASTATIN AND FLUOROMEVALONATE ON Phosphatidylinositol 3‐kinase ACTIVITY STIMULATED WITH PDGF
- … factor induces the tyrosine phosphorylation and activation of phospholipase C-gamma 1, Fyn and Lyn kinases, and Phosphatidylinositol 3–kinase in a human B cell …
- Protein kinase C-mediated formation of Phosphatidylinositol 3, 4-bisphosphate in human platelets
- EJ-Ras Inhibits Phospholipase Cγ1 but Not Actin Polymerization Induced by Platelet-Derived Growth Factor-BB via Phosphatidylinositol 3–kinase
- Controlled overexpression of selected domains of the P85 subunit of Phosphatidylinositol 3–kinase reverts v-Ha-Ras transformation
- Insulin-like growth factor-1-mediated association of p85 Phosphatidylinositol 3–kinase with pp 185: requirement of SH2 domains for in vivo interaction.
- The differential activation of Phosphatidylinositol–3 kinase and mitogen-activated protein kinases by PDGF-AA and IGF-I might explain the synergistic effect of the two …
- CD28‐dependent killing by human YT cells requires Phosphatidylinositol 3‐kinase activation
- Phosphoinositide 3-phosphatase segregates from Phosphatidylinositol 3–kinase in EGF-stimulated A431 cells and fails to in vitro hydrolyse Phosphatidylinositol (3, 4 …
- … p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or Phosphatidylinositol–3–kinase.
- Synthesis of Phosphatidylinositol 3, 4-bisphosphate is regulated by protein-tyrosine phosphorylation but the p85α subunit of Phosphatidylinositol 3–kinase may not be …
- Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for Phosphatidylinositol 3–kinase
- Inhibition of IGF II-induced redistribution of mannose 6-phosphate receptors by the Phosphatidylinositol 3–kinase inhibitor, wortmannin
- A novel pathway for the formation of Phosphatidylinositol 3, 4-bisphosphate. Phosphorylation of Phosphatidylinositol 3-monophosphate by …
- Novel protein kinase/Phosphatidylinositol 3–kinase complex essential for receptor-mediated protein sorting to the vacuole in yeast
- Haematopoietic colony stimulating factors CSF-1 and GM-CSF increase Phosphatidylinositol 3–kinase activity in murine bone marrow-derived macrophages
- Isolation of the active form of RAC‐protein kinase (PKB/Akt) from transfected COS‐7 cells treated with heat shock stress and effects of Phosphatidylinositol 3, 4, 5 …
- Association of the insulin receptor and Phosphatidylinositol 3–kinase requires a third component
- Interleukin-4 activates two distinct pathways of Phosphatidylinositol–3 kinase in the same cells
- Dominant negative effect of the truncated p110 subunit of Phosphatidylinositol‐3 kinase
- … FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of Phosphatidylinositol 3–kinase but not mitogen …
- Inhibition of Neuroblastoma Cell Phosphatidylinositol 3‐kinase by CDP‐Diacylglycerol and Phosphatidate
- Regulation of Phosphatidylinositol–3 kinase by tyrosyl phosphoproteins
- D-myo-Inositol 1, 4, 5-trisphosphate analogues modified at the 3-position inhibit Phosphatidylinositol 3–kinase
- Detection of a 60 kDa tyrosine-phosphorylated protein in insulin-stimulated hepatoma cells that associates with the SH2 domain of Phosphatidylinositol 3–kinase
- Serine-rich region of the IL-2 receptor β-chain is required for activation of Phosphatidylinositol 3–kinase
- In vitro association of the Phosphatidylinositol 3‐kinase regulatory subunit (p85) with the human insulin receptor
- Phosphatidylinositol 3–kinase is involved in TRE-dependent gene expression in response to arginine vasopressin
- Dissociation of Phosphatidylinositol–3 kinase activity and mitogenic inhibition in vascular smooth muscle cells
- … H2O2 and vanadate enhances insulin receptor mediated tyrosine phosphorylation of IRS‐1 leading to IRS‐1 association with the Phosphatidylinositol 3‐kinase
- Characterization of a Phosphatidylinositol-specific phosphoinositide 3–kinase from mammalian cells
- Insulin-dependent Phosphatidylinositol 3′-kinase activity co-precipitates with insulin receptor in human circulating mononuclear cells
- Phosphatidylinositol (PI) 3–kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3–kinase but not PI 4-kinase
- O-17: Overexpression of a constitutively active form of Phosphatidylinositol 3 kinase is sufficient to Promote GLUT 4 translocation in transfected rat adipose cells
- Platelet-Derived Growth Factor Induces Phosphatidylinositol 3–kinase Release from the Middle T-pp60c-src Complex and Association with the Platelet-Derived …
- Phosphatidylinositol 3–kinase: A Novel Signal Transduction Pathway?
- Up-regulation of Expression of Phosphatidylinositol 3–kinase in Psoriatic Lesions
- A Phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3–kinase homologs …
- Differential roles of Phosphatidylinositol 3–kinase in mitogen-activated prote in kinase activation by insulin and epidermal growth factor
- Production of monoclonal antibodies specific to the carboxyl terminal region of the 85 kDa subunit of Phosphatidylinositol 3‐kinase: Use of the antibodies in …
- Phosphatidylinositol 3–kinase is involved in the colony-stimulating factor-1-induced spreading of macrophages and osteoclasts.
- Purification of Phosphatidylinositol 3–kinase by SDS-agarose gel electrophoresis and HPEC
- Does Phosphatidylinositol 3‐kinase play a role in insulin‐induced outgrowth of pseudopodial cables in cultured cells derived from micromeres of sea urchin embryos?
- Phosphatidylinositol–3–kinase Pathway is Stimulated by Fungal Lipid Containing Cocoa Butter Equivalents (CBE) in FMet-Leu-Phe (FMLP)-and Phorbolester (PMA) …
- A structural and functional analysis of the Phosphatidylinositol 3–kinase
- Engagement of the osteoclast integrin alpha v beta 3 by osteopontin stimulates Phosphatidylinositol 3-hydroxyl kinase activity
- O-49: A prevalent amino acid polymorphism at codon 325Met-> IIe in the gene encoding the Phosphatidylinositol 3–kinase p85α regulatory subunit is associated with …
- Activation of PRK1 by Phosphatidylinositol 4, 5-Bisphosphate and Phosphatidylinositol 3, 4, 5-Trisphosphate: A COMPARISON WITH PROTEIN kinase C …
- Characterization of tyrosine kinase-associated Phosphatidylinositol–3 kinase.
- The experimental study on Phosphatidylinositol 3–kinase/Akt in neural stem cells in vitro
- Phosphatidylinositol 3–kinase activation by IGF-I is independent of irs-1 in hl-60 cells
- Role of Phosphatidylinositol 3–kinase in growth factor and oncogene signaling
- Purification and characterisation of Phosphatidylinositol 3–kinase from bovine brain
- CD19 and Phosphatidylinositol 3–kinase
- Activation of Phosphatidylinositol 3–kinase in hepatocyte growth and hepatocellular transformation
- Phosphatidylinositol 3–kinase (PI3k) is required for chemoattractant-stimulated homotypic aggregation of human neutropfflls
- Shear stress-induced signal transduction through Phosphatidylinositol–3 kinase in endothelial cells
- Early events in insulin signaling: Tyrosine phosphorylation and Phosphatidylinositol 3–kinase activation
- Profilin and gelsolin stimulate Phosphatidylinositol 3–kinase activity
- Phosphatidylinositol 3–kinase Activity in 3T3-L1 Adipocytes: Effects of Pioglitazone on Insulin-and IGF-1-Stimulated Cells
- Phosphatidylinositol 3–kinase Activity Is Required for Hepatocyte Growth Factor-induced Mitogenic Signals in Epithelial Cells
- Role of Phosphatidylinositol 3–kinase during the first cell cycles of the sea urchin embryo. Effect on map kinase and MPF activities.
- P-62: Role of Phosphatidylinositol–3–kinase and S6 kinase in insulin-stimulated glycogen synthesis
- The effects of fluid shear stress on the activity of protein kinase C, Phosphatidylinositol 3–kinase and Rho in aortic endothelial cells
- Role of p38 and Phosphatidylinositol 3 kinase (PI3K) in the signal transduction of apoptosis of activated human?? T cells induced by restimulating with Mycobacterium …
- Phosphatidylinositol 3 kinase (PI 3 K) regulates glomerular mesangial cell chemotaxis and proliferation: Involvement of mitogen activated protein kinase (MAPK) …
- Phosphatidylinositol 3–kinase regulates actin stress fiber formation and the avidity of the integrin-receptor α, β 3 in human melanoma cells.
- Regulation of early endosomal transport and fusion by ADP-ribosylation factors and Phosphatidylinositol 3–kinase
- P-78: Role of p85 isoforms of Phosphatidylinositol–3–kinase in insulin receptor signaling
- Translocation of Phosphatidylinositol–3 kinase (PI3–kinase) and small GTPase Rho A to the cytoskeleton upon osteoclast attachment to bone.
- Phosphatidylinositol 3–kinase regulates actin stress fiber formation and the avidity of the integrin-receptor αvβ3 in human melanoma cells.
- Tyrosine residue 719 of the c-kit receptor is essential for binding of the P85 subunit of Phosphatidylinositol (PI) 3–kinase and for c-kit-associated PI 3–kinase activity in …
- … derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through Phosphatidylinositol 3–kinase binding sites on …
- P-77: Insulinomimetic agent, vanadyl sulfate (VS)-stimulated Phosphatidylinositol 3–kinase (PI 3-K) and RAS/MAP kinase activation is independent of insulin receptor …
- Effect of phosphotyrosyl‐IRS‐1 level and insulin receptor tyrosine kinase activity on insulin‐stimulated Phosphatidylinositol 3, MAP, and S6 kinase activities
- Phosphorylation of Tyrosine 503 in the Erythropoietin Receptor (EpR) Is Essential for Binding the P85 Subunit of Phosphatidylinositol (PI) 3–kinase and for …
- Protein kinase B (c-Akt): a multifunctional mediator of Phosphatidylinositol 3–kinase activation
- A requirement for Phosphatidylinositol 3–kinase in pseudopod extension
- Downstream signalling events regulated by Phosphatidylinositol 3–kinase activity
- p110δ, a novel Phosphatidylinositol 3–kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
- A specific product of Phosphatidylinositol 3–kinase directly activates the protein kinase Akt through its pleckstrin homology domain
- The role of Phosphatidylinositol 3–kinase in vascular endothelial growth factor signaling
- Cyclin D expression is controlled post-transcriptionally via a Phosphatidylinositol 3–kinase/Akt-dependent pathway
- Role of glycogen synthase kinase–3 in the Phosphatidylinositol 3–kinase/Akt cell survival pathway
- Antiapoptotic signalling by the insulin-like growth factor I receptor, Phosphatidylinositol 3–kinase, and Akt
- Calmodulin activates Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase-dependent membrane association of the Bruton’s tyrosine kinase pleckstrin homology domain visualized in single living cells
- Regulation of the p85/p110 Phosphatidylinositol 3′-kinase: stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit
- Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
- Ezrin, a plasma membrane–microfilament linker, signals cell survival through the Phosphatidylinositol 3–kinase/Akt pathway
- Suppression of transforming growth factor-β-induced apoptosis through a Phosphatidylinositol 3–kinase/Akt-dependent pathway
- Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the Phosphatidylinositol 3–kinase/Akt pathway
- PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent Phosphatidylinositol 3–kinase/Akt cell survival pathway
- Vascular endothelial growth factor regulates endothelial cell survival through the Phosphatidylinositol 3′-kinase/Akt signal transduction pathway …
- Depolarization and neurotrophins converge on the Phosphatidylinositol 3–kinase–Akt pathway to synergistically regulate neuronal survival
- Relationship between flavonoid structure and inhibition of Phosphatidylinositol 3–kinase: a comparison with tyrosine kinase and protein kinase C inhibition
- Myogenic signaling of Phosphatidylinositol 3–kinase requires the serine-threonine kinase Akt/protein kinase B
- Requirement of Phosphatidylinositol 3–kinase in focal adhesion kinase-promoted cell migration
- Identification of an early endosomal protein regulated by Phosphatidylinositol 3–kinase
- Activation of the Phosphatidylinositol 3–kinase serine kinase by IFN-alpha.
- The Phosphatidylinositol 3‐kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
- Constitutive activation of Phosphatidylinositol 3–kinase by a naturally occurring mutant epidermal growth factor receptor
- Akt, a target of Phosphatidylinositol 3–kinase, inhibits apoptosis in a differentiating neuronal cell line
- Regulation of the p85/p110α Phosphatidylinositol 3′-kinase: distinct roles for the N-terminal and C-terminal SH2 domains
- Activated Phosphatidylinositol 3–kinase and Akt kinase promote survival of superior cervical neurons
- Increased levels of Phosphatidylinositol 3‐kinase activity in colorectal tumors
- Protein kinase C-ζ as a downstream effector of Phosphatidylinositol 3–kinase during insulin stimulation in rat adipocytes: potential role in glucose transport
- Phosphatidylinositol 3–kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
- Phosphatidylinositol 3‐kinase‐mediated regulation of neuronal apoptosis and necrosis by insulin and IGF‐I
- Identification and analysis of PH domain-containing targets of Phosphatidylinositol 3–kinase using a novel in vivo assay in yeast
- Phosphatidylinositol 3–kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
- Comparison of the roles of mitogen-activated protein kinase kinase and Phosphatidylinositol 3–kinase signal transduction in neutrophil effector function
- Activation of Phosphatidylinositol 3–kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-κB p65/RelA subunit
- Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3–kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells …
- Activation of Phosphatidylinositol 3–kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
- STAT3 as an adapter to couple Phosphatidylinositol 3–kinase to the IFNAR1 chain of the type I interferon receptor
- Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires Phosphatidylinositol 3–kinase
- Heregulin induces phosphorylation of BRCA1 through Phosphatidylinositol 3–kinase/AKT in breast cancer cells
- Phosphatidylinositol 3–kinase is required for platelet-derived growth factor’s actions on hepatic stellate cells
- FAK is the upstream signal protein of the Phosphatidylinositol 3–kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human …
- An essential role of Phosphatidylinositol 3–kinase in myogenic differentiation
- Phosphatidylinositol 3–kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases
- Phosphatidylinositol 3–kinase in interleukin 1 signaling: physical interaction with the interleukin 1 receptor and requirement in NFκB and AP-1 activation
- Insulin-like growth factor 1 inhibits apoptosis using the Phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways
- The Phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells
- … the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions: evidence for the association of Phosphatidylinositol 3–kinase with the E …
- Angiotensin II activates Phosphatidylinositol 3–kinase in vascular smooth muscle cells
- p85α gene generates three isoforms of regulatory subunit for Phosphatidylinositol 3–kinase (PI 3–kinase), p50α, p55α, and p85α, with different PI 3–kinase …
- Effects of free fatty acids on glucose transport and IRS-1–associated Phosphatidylinositol 3–kinase activity
- Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction–and Phosphatidylinositol–3–kinase–independent pathway
- Adenoviral gene transfer of activated Phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro
- Interleukin 8-stimulated Phosphatidylinositol–3–kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and …
- Differentiated phenotype of smooth muscle cells depends on signaling pathways through insulin-like growth factors and Phosphatidylinositol 3–kinase
- The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and Phosphatidylinositol 3–kinase-dependent signaling
- Inhibition of adipose differentiation by Phosphatidylinositol 3‐kinase inhibitors
- Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of Phosphatidylinositol 3–kinase
- Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase in cultured neurons.
- Phosphatidylinositol 3–kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase
- Distinct roles of the Phosphatidylinositol 3–kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors
- MAP kinases, Phosphatidylinositol 3‐kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor
- Requirement for both Shc and Phosphatidylinositol 3′ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis
- Negative regulation by Phosphatidylinositol 3–kinase of inducible nitric oxide synthase expression in macrophages
- c-Src is required for stimulation of gelsolin-associated Phosphatidylinositol 3–kinase
- Altered expression levels and impaired steps in the pathway to Phosphatidylinositol 3–kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats
- Contribution of Phosphatidylinositol 3‐kinase to radiation resistance in human melanoma cells
- Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the Phosphatidylinositol 3–kinase signaling pathway.
- Increase in nuclear Phosphatidylinositol 3‐kinase activity and Phosphatidylinositol (3, 4, 5) trisphosphate synthesis precede PKC‐ζ translocation to the nucleus of NGF …
- Src-induced activation of inducible T cell kinase (ITK) requires Phosphatidylinositol 3–kinase activity and the Pleckstrin homology domain of inducible T cell kinase
- Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a Phosphatidylinositol 3′-kinase and phospholipase C-dependent mechanism
- … oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the Phosphatidylinositol 3–kinase …
- Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell–cell adhesion or cell migration and is regulated by Phosphatidylinositol 3–kinase
- Platelet-derived growth factor β receptor regulates interstitial fluid homeostasis through Phosphatidylinositol–3′ kinase signaling
- Wortmannin, a specific inhibitor of Phosphatidylinositol–3–kinase, enhances LPS-induced NO production from murine peritoneal macrophages
- Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of Phosphatidylinositol 3′-kinase and Akt/protein kinase B
- Extracellular‐regulated kinases and Phosphatidylinositol 3‐kinase are involved in brain‐derived neurotrophic factor‐mediated survival and neuritogenesis of the …
- Phosphatidylinositol 3–kinase mediates mitogen-induced human airway smooth muscle cell proliferation
- Phosphatidylinositol 3‐kinase is recruited to a specific site in the activated IL‐1 receptor I
- Phosphatidylinositol 3–kinase is a negative regulator of cellular differentiation
- Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of Phosphatidylinositol 3′-kinase and is involved in interleukin 6-induced …
- Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of Phosphatidylinositol 3–kinase and Akt
- The Antiapoptotic Gene mcl-1 Is Up-Regulated by the Phosphatidylinositol 3–kinase/Akt Signaling Pathway through a Transcription Factor Complex Containing …
- Cyclin D1 Expression Mediated by Phosphatidylinositol 3–kinase through mTOR-p70S6K-Independent Signaling in Growth Factor-Stimulated NIH 3T3 Fibroblasts
- Regulation of vascular smooth muscle cell apoptosis: modulation of Bad by a Phosphatidylinositol 3–kinase–dependent pathway
- Activated MEK stimulates expression of AP-1 components independently of Phosphatidylinositol 3–kinase (PI3–kinase) but requires a PI3–kinase signal to stimulate …
- Phosphatidylinositol 3–kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway
- Distinct Phosphatidylinositol 3–kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses
- Activation of Phosphatidylinositol 3–kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes
- Inhibition of Phosphatidylinositol 3–kinase activity blocks depolarization-and insulin-like growth factor I-mediated survival of cerebellar granule cells
- Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via Phosphatidylinositol–3 kinase
- p70s6k Integrates Phosphatidylinositol 3–kinase and Rapamycin-Regulated Signals for E2F Regulation in T Lymphocytes
- Inhibition of Phosphatidylinositol 3–kinase activity by adenovirus-mediated gene transfer and its effect on insulin action
- … -permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a Phosphatidylinositol 3–kinase-dependent stimulation of the …
- Insulin stimulation of the fatty acid synthase promoter is mediated by the Phosphatidylinositol 3–kinase pathway: involvement of protein kinase B/Akt
- Phosphatidylinositol 3–kinase γ mediates shear stress-dependent activation of JNK in endothelial cells
- Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not Phosphatidylinositol 3–kinase in rat skeletal muscle.
- αPIX nucleotide exchange factor is activated by interaction with Phosphatidylinositol 3–kinase
- Insulin receptor substrate-1 phosphorylation and Phosphatidylinositol 3–kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
- Dedifferentiation of adenocarcinomas by activation of Phosphatidylinositol 3–kinase
- Role of Phosphatidylinositol 3–kinase activation in the hypertrophic growth of adult ventricular cardiomyocytes
- A redox-triggered ras-effector interaction: recruitment of Phosphatidylinositol 3′-kinase to Ras by redox stress
- Intermolecular interactions of the p85α regulatory subunit of Phosphatidylinositol 3–kinase
- Vac1p coordinates Rab and Phosphatidylinositol 3–kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome
- Requirement of Phosphatidylinositol–3 kinase for activation of JNK/SAPKs by PDGF
- 1α,25-Dihydroxyvitamin D3–Induced Myeloid Cell Differentiation Is Regulated by a Vitamin D Receptor–Phosphatidylinositol 3–kinase Signaling Complex
- Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and Phosphatidylinositol 3–kinase in 3T3-L1 adipocytes: a …
- … rescue cerebellar granule neurons from oxidative stress‐mediated apoptotic death: selective involvement of Phosphatidylinositol 3‐kinase and the mitogen‐activated …
- Phosphatidylinositol 3–kinase activation is required for insulin-stimulated sodium transport in A6 cells
- Requirement of Phosphatidylinositol 3–kinase-dependent pathway and Src for Gas6-Axl mitogenic and survival activities in NIH 3T3 fibroblasts
- The p85 subunit of Phosphatidylinositol 3–kinase associates with the Fc receptor γ-chain and linker for activitor of T cells (LAT) in platelets stimulated by …
- Phosphatidylinositol 3–kinase-dependent activation of protein kinase C-ζ in bacterial lipopolysaccharide-treated human monocytes
- Expression of a constitutively active Phosphatidylinositol 3–kinase induces process formation in rat PC12 cells: use of Cre/loxP recombination system
- Inhibition of Phosphatidylinositol 3–kinase induces nitric-oxide synthase in lipopolysaccharide-or cytokine-stimulated C6 glial cells
- Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the Phosphatidylinositol 3–kinase pathway in spinal …
- AKT2, a Member of the Protein kinase B Family, Is Activated by Growth Factors, v-Ha-ras, and v-src through Phosphatidylinositol 3–kinase in Human Ovarian …
- Activation of protein kinase C-ζ and Phosphatidylinositol 3′-kinase and promotion of macrophage differentiation by insulin-like growth factor-I
- Phosphatidylinositol 3–kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering
- Downstream of Phosphatidylinositol–3 kinase, a multifunctional signaling molecule, and its regulation in cell responses
- Human dopamine D3 receptors mediate mitogen-activated protein kinase activation via a Phosphatidylinositol 3–kinase and an atypical protein kinase C-dependent …
- Phosphatidylinositol‐3 kinase is involved in ruffled border formation in osteoclasts
- Membrane-targeted Phosphatidylinositol 3–kinase mimics insulin actions and induces a state of cellular insulin resistance
- A function for Phosphatidylinositol 3–kinase β (p85α-p110β) in fibroblasts during mitogenesis: requirement for insulin-and lysophosphatidic acid-mediated signal …
- Phosphatidylinositol 3‐kinase and Akt protein kinase mediate IGF‐I‐and prosaptide‐induced survival in Schwann cells
- Activation of Phosphatidylinositol 3‐kinase, but not extracellular‐regulated kinases, is necessary to mediate brain‐derived neurotrophic factor‐induced motoneuron …
- Phosphatidylinositol 3–kinase contributes to cell volume regulation through effects on ATP release
- Phosphatidylinositol 3–kinase is required for the formation of constitutive transport vesicles from the TGN
- Enhanced Phosphatidylinositol 3–kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation
- A collagen-related peptide regulates phospholipase Cγ2 via Phosphatidylinositol 3–kinase in human platelets
- Phosphatidylinositol 3‐kinase: increased activity and protein level in amyotrophic lateral sclerosis
- Enhanced insulin-stimulated activation of Phosphatidylinositol 3–kinase in the liver of high-fat-fed rats.
- SHP-1 regulates Lck-induced Phosphatidylinositol 3–kinase phosphorylation and activity
- Insulin-like growth factors require Phosphatidylinositol 3–kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells
- DHEA improves glucose uptake via activations of protein kinase C and Phosphatidylinositol 3–kinase
- Insulin-like growth factor-II, Phosphatidylinositol 3–kinase, nuclear factor-κB and inducible nitric-oxide synthase define a common myogenic signaling pathway
- Phosphorylation of CD19 Y484 and Y515, and linked activation of Phosphatidylinositol 3–kinase, are required for B cell antigen receptor-mediated activation of …
- The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase–3 signaling pathway via Phosphatidylinositol 3–kinase
- Endosomal recycling of the Na+/H+ exchanger NHE3 isoform is regulated by the Phosphatidylinositol 3–kinase pathway
- Differential effects of constitutively active Phosphatidylinositol 3–kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes
- Interleukin-6 inhibits transforming growth factor-β-induced apoptosis through the Phosphatidylinositol 3–kinase/Akt and signal transducers and activators of …
- … in response to dexamethasone is associated with inhibition of insulin-like growth factor-I stimulated Phosphatidylinositol 3–kinase activity in cultured muscle …
- Requirement for Phosphatidylinositol–3′-kinase in cytokine-mediated germ cell survival during fetal oogenesis in the mouse
- Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for Phosphatidylinositol 3–kinase in adipocytes from subjects with non-insulin …
- Defective regulation of Phosphatidylinositol–3–kinase gene expression in skeletal muscle and adipose tissue of non-insulin-dependent diabetes mellitus patients
- … transporter mRNAs in response to insulin: role of mammalian target of rapamycin, protein kinase b, and Phosphatidylinositol 3–kinase in GLUT1 mRNA …
- Grb2-associated binder-1 mediates Phosphatidylinositol 3–kinase activation and the promotion of cell survival by nerve growth factor
- Phosphorylation–dependent interaction of the N‐methyl‐ d‐aspartate receptor ε2 subunit with Phosphatidylinositol 3‐kinase
- Differential regulation of insulin receptor substrates-1 and-2 (IRS-1 and IRS-2) and Phosphatidylinositol 3–kinase isoforms in liver and muscle of the obese diabetic (ob …
- Phosphatidylinositol 3–kinase-mediated Endocytosis of Renal Na+,K+-ATPase α Subunit in Response to Dopamine
- Involvement of Phosphatidylinositol 3–kinase in stromal cell-derived factor-1α-induced lymphocyte polarization and chemotaxis
- Protein kinase B (c-Akt), Phosphatidylinositol 3–kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an …
- Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via Phosphatidylinositol 3–kinase
- Inhibition of Phosphatidylinositol–3–kinase blocks development of functional embryonic cardiomyocytes
- … prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1,-2, and-3, their association with p85 Phosphatidylinositol 3–kinase (PI3–kinase), and …
- Roles of Phosphatidylinositol 3–kinase and mitogen-activated protein kinase pathways in stimulation of vascular smooth muscle cell migration and deoxyriboncleic …
- TGF-β1 modulates EGF-stimulated Phosphatidylinositol 3–kinase activity in human airway smooth muscle cells
- Phosphatidylinositol 3–kinase is involved in the protection of primary cultured human erythroid precursor cells from apoptosis
- Phosphatidylinositol 3–kinase is a target for protein tyrosine nitration
- Phosphatidylinositol–3 kinase is necessary for 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation
- p21 ras and Phosphatidylinositol–3 kinase are required for survival of wild-type and NF1 mutant sensory neurons
- Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/Phosphatidylinositol 3–kinase pathway
- … -activated protein kinase activation through Fcε receptor I and stem cell factor receptor is differentially regulated by Phosphatidylinositol 3–kinase and calcineurin in …
- Microinjection of activated Phosphatidylinositol–3 kinase induces process outgrowth in rat PC12 cells through the Rac-JNK signal transduction pathway
- Prolactin induced tyrosine phosphorylation of p59fyn may mediate Phosphatidylinositol 3–kinase activation in Nb2 cells.
- Glucagon-like peptide-1 promotes DNA synthesis, activates Phosphatidylinositol 3–kinase and increases transcription factor pancreatic and duodenal homeobox gene …
- Phosphatidylinositol 3–kinase is involved in the induction of macrophage growth by oxidized low density lipoprotein
- Phosphatidylinositol 3–kinase Requirement in Activation of the ras/C-raf-1/MEK/ERK and p70s6k Signaling Cascade by the Insulinomimetic Agent Vanadyl Sulfate
- Ataxia‐telangiectasia without immunodeficiency: Novel point mutations within and adjacent to the Phosphatidylinositol 3‐kinase‐like domain
- Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-Kit, Phosphatidylinositol 3–kinase, and p120CBL
- Modification of Phosphatidylinositol 3–kinase SH2 domain binding properties by Abl-or Lck-mediated tyrosine phosphorylation at Tyr-688
- Identification of a common amino acid polymorphism in the p85α regulatory subunit of Phosphatidylinositol 3–kinase: effects on glucose disappearance constant …
- Region‐specific mRNA expression of Phosphatidylinositol 3‐kinase regulatory isoforms in the central nervous system of C57BL/6J mice
- Heat shock activates c-Src tyrosine kinases and Phosphatidylinositol 3–kinase in NIH3T3 fibroblasts
- Evidence of a role for Phosphatidylinositol 3–kinase activation in the blocking of apoptosis by polyomavirus middle T antigen
- Comparative Effects of GTPγS and Insulin on the Activation of Rho, Phosphatidylinositol 3–kinase, and Protein kinase N in Rat Adipocytes: RELATIONSHIP …
- Nerve growth factor protects PC12 cells against peroxynitrite‐induced apoptosis via a mechanism dependent on Phosphatidylinositol 3‐kinase
- Activation of Phosphatidylinositol 3–kinase, protein kinase B, and p70 S6 kinases in lipopolysaccharide-stimulated Raw 264.7 cells: differential effects of rapamycin …
- Phosphatidylinositol 3–kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading
- … of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of Phosphatidylinositol 3–kinase and the GRP1 …
- Thymocyte activation induces the association of Phosphatidylinositol 3‐kinase and pp120 with CD5
- Heregulin β1-activated Phosphatidylinositol 3–kinase enhances aggregation of MCF-7 breast cancer cells independent of extracellular signal-regulated kinase
- Phosphatidylinositol 3–kinase Is Required for Growth Factor–Induced Amino Acid Uptake by Vascular Smooth Muscle Cells
- The proto-oncogene product p120cbl links c-Src and Phosphatidylinositol 3′-kinase to the integrin signaling pathway
- CD28 receptor endocytosis is targeted by mutations that disrupt Phosphatidylinositol 3–kinase binding and costimulation
- Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a Phosphatidylinositol 3–kinase-dependent mechanism
- Assessment of the roles of mitogen-activated protein kinase, Phosphatidylinositol 3–kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP …
- Thrombopoietin induces activation of the Phosphatidylinositol‐3′ kinase pathway and formation of a complex containing p85PI3K and the protooncoprotein p120CBL
- Signaling through CD5 activates a pathway involving Phosphatidylinositol 3–kinase, Vav, and Rac1 in human mature T lymphocytes
- Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with Phosphatidylinositol 3–kinase
- Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP, and Phosphatidylinositol 3–kinase
- Epidermal growth factor modulates tyrosine phosphorylation of p130Cas: involvement of Phosphatidylinositol 3′-kinase and actin cytoskeleton
- Phosphatidylinositol 3′-kinase and SH2-containing inositol phosphatase (SHIP) are recruited by distinct positive and negative growth-regulatory domains in the …
- Selective up-regulation of Phosphatidylinositol 3′-kinase activity in Th2 cells inhibits caspase-8 cleavage at the death-inducing complex: a mechanism for Th2 …
- Inhibition of Phosphatidylinositol 3–kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons
- Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of Phosphatidylinositol 3–kinase and is independent of insulin receptor tyrosine …
- Phosphatidylinositol 3–kinase-dependent and-independent cytolytic effector functions
- Activation of Phosphatidylinositol 3–kinase by interleukin-13: an inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29
- G1 phase arrest by the Phosphatidylinositol 3–kinase inhibitor LY 294002 is correlated to up-regulation of p27Kip1 and inhibition of G1 CDKs in choroidal …
- Phosphatidylinositol 3′-kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation …
- … Tyrosine Phosphorylation of p130Cas, Focal Adhesion kinase, and Paxillin: ROLE OF Phosphatidylinositol 3′-kinase AND FORMATION OF A …
- Gastrin stimulates the formation of a p60Src/p125FAK complex upstream of the Phosphatidylinositol 3–kinase signaling pathway
- A Phosphatidylinositol 3–kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts
- A Phosphatidylinositol 3–kinase and Phosphatidylinositol transfer protein act synergistically in formation of constitutive transport vesicles from the trans-Golgi …
- Insulin-like growth factor (IGF)-I regulates IGF-binding protein-5 gene expression through the Phosphatidylinositol 3–kinase, protein kinase B/Akt, and p70 S6 …
- α-Adrenergic stimulation mediates glucose uptake through Phosphatidylinositol 3–kinase in rat heart
- A Phosphatidylinositol 3‐kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation
- Intracellular movement of green fluorescent protein–tagged Phosphatidylinositol 3–kinase in response to growth factor receptor signaling
- Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes: apparent involvement of Phosphatidylinositol 3–kinase
- Intermediate affinity interleukin-2 receptor mediates survival via a Phosphatidylinositol 3–kinase-dependent pathway
- The Phosphatidylinositol 3–kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human …
- … pervanadate, stimulate glucose transport and GLUT translocation in muscle cells by a mechanism independent of Phosphatidylinositol 3–kinase and protein kinase C.
- The Phosphatidylinositol 3‐kinase inhibitor wortmannin alters the metabolism of the Alzheimer’s amyloid precursor protein
- … tyrosine kinase inhibits inducible nitric oxide synthase (iNOS) expression by murine peritoneal exudate macrophages: Phosphatidylinositol–3 kinase is required for …
- Involvement of Phosphatidylinositol 3–kinase in NFAT activation in T cells
- Endothelin-1 modulates insulin signaling through Phosphatidylinositol 3–kinase pathway in vascular smooth muscle cells.
- Phosphatidylinositol 3–kinase in HL-60 nuclei is bound to the nuclear matrix and increases during granulocytic differentiation
- Multiple isoforms of the regulatory subunit for Phosphatidylinositol 3–kinase (PI3–kinase) are expressed in neurons in the rat brain
- The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 Phosphatidylinositol 3–kinase and the class II PI3K-C2α
- The p85 and p110 subunits of Phosphatidylinositol 3–kinase-α are substrates, in vitro, for a constitutively associated protein tyrosine kinase in platelets
- Phosphatidylinositol 3–kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma …
- The epidermal growth factor receptor associates with and recruits Phosphatidylinositol 3–kinase to the platelet-derived growth factor β receptor
- The Phosphatidylinositol 3′ kinase pathway is required for the survival signal of leukocyte tyrosine kinase
- Phosphatidylinositol 3–kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes
- Stimulation of IRS-1-associated Phosphatidylinositol 3–kinase and Akt/protein kinase B but not glucose transport by β1-integrin signaling in rat adipocytes
- … colony-stimulating factor-activated signaling pathways in human neutrophils: involvement of Jak2 in the stimulation of Phosphatidylinositol 3–kinase
- CD38 ligation in human B cell progenitors triggers tyrosine phosphorylation of CD19 and association of CD19 with lyn and Phosphatidylinositol 3–kinase.
- MAP kinase activation by mu opioid receptor involves Phosphatidylinositol 3–kinase but not the cAMP/PKA pathway
- Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cγ or Phosphatidylinositol 3 kinase
- Sublytic C5b-9 induces proliferation of human aortic smooth muscle cells: role of mitogen activated protein kinase and Phosphatidylinositol 3–kinase
- … novel pathway for tumor necrosis factor-α and ceramide signaling involving sequential activation of tyrosine kinase, p21ras, and Phosphatidylinositol 3–kinase
- Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the Phosphatidylinositol 3–kinase pathway and cardiac chamber …
- Calmodulin is involved in membrane depolarization-mediated survival of motoneurons by Phosphatidylinositol–3 kinase-and MAPK-independent pathways
- p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for Phosphatidylinositol 3–kinase and p38 MAP kinase
- Phosphatidylinositol 3–kinase and Ca2+ influx dependence for ligand-stimulated internalization of the c-Kit receptor
- Epidermal growth factor receptor-regulated human bladder cancer motility is in part a Phosphatidylinositol 3–kinase-mediated process
- Involvement of Phosphatidylinositol–3 kinase in prevention of low K+-induced apoptosis of cerebellar granule neurons
- PTEN modulates cell cycle progression and cell survival by regulating Phosphatidylinositol 3, 4, 5,-trisphosphate and Akt/protein kinase B signaling pathway
- … lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving Phosphatidylinositol 3–kinase and phospholipase D …
- CD28 can promote T cell survival through a Phosphatidylinositol 3‐kinase‐independent mechanism
- SIP/SHIP inhibits Xenopus oocyte maturation induced by insulin and Phosphatidylinositol 3–kinase
- Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires Phosphatidylinositol 3–kinase
- Lysophosphatidylcholine generates superoxide anions through activation of Phosphatidylinositol 3–kinase in human neutrophils
- Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with Phosphatidylinositol 3–kinase in skeletal muscle cells
- The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires Phosphatidylinositol 3‐kinase and Akt
- Nuclear translocation of PKCζ during ischemia and its inhibition by wortmannin, an inhibitor of Phosphatidylinositol 3–kinase
- CD7-mediated regulation of integrin adhesiveness on human T cells involves tyrosine phosphorylation-dependent activation of Phosphatidylinositol 3–kinase.
- LCK-phosphorylated human killer cell-inhibitory receptors recruit and activate Phosphatidylinositol 3–kinase
- 14-3–3β protein associates with insulin receptor substrate 1 and decreases insulin-stimulated Phosphatidylinositol 3′-kinase activity in 3T3L1 adipocytes
- Evidence that Phosphatidylinositol 3–kinase and p70S6K protein are involved in differentiation of HL-60 cells induced by calcitriol.
- Inhibition of Phosphatidylinositol 3‐kinase activity blocks cellular differentiation mediated by glial cell line‐derived neurotrophic factor in dopaminergic neurons
- Roles of Phosphatidylinositol 3–kinase and Rac in the nuclear signaling by tumor necrosis factor-α in rat-2 fibroblasts
- Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting Phosphatidylinositol–3′ kinase
- The role of Phosphatidylinositol 3–kinase, Src kinase, and protein kinase A signaling pathways in insulin and glucagon regulation of CYP2E1 expression
- Mitogen-activated protein kinase and Phosphatidylinositol 3–kinase pathways are not sufficient for insulin-like growth factor I-induced mitogenesis and tumorigenesis
- Fc receptor-mediated platelet activation is dependent on Phosphatidylinositol 3–kinase activation and involves p120cbl
- Variant in the regulatory subunit of Phosphatidylinositol 3–kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin …
- … 3–kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85α regulatory subunit of Phosphatidylinositol 3–kinase …
- The involvement of Phosphatidylinositol 3–kinase in crystal induced human neutrophil activation.
- Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive Phosphatidylinositol–3–kinase
- … receptors gives rise to the selective modulation of intracellular signaling in B cells: regulation of the association of Phosphatidylinositol 3–kinase and inositol 5 …
- Phosphatidylinositol 3′-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen
- Phosphorylation of cbl after Stimulation of Nb2 Cells with Prolactin and Its Association with Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding
- Regulation of endocytic-transcytotic pathways and bile secretion by Phosphatidylinositol 3–kinase in rats
- Cripto-1 induces Phosphatidylinositol 3′-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3β in human cervical carcinoma cells
- Epidermal growth factor stimulation of Phosphatidylinositol 3–kinase during wound closure in rabbit corneal epithelial cells.
- … induces the tyrosine phosphorylation of insulin receptor substrate-2: an alternate pathway for erythropoietin-induced Phosphatidylinositol 3–kinase activation
- Localization of a class II Phosphatidylinositol 3–kinase, PI3KC2α, to clathrin-coated vesicles
- Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and Phosphatidylinositol 3–kinase activity
- Possible involvement of Phosphatidylinositol 3‐kinase in regulated exocytosis: studies in chromaffin cells with inhibitor LY294002
- Src-family Tyrosine kinases in Activation of ERK-1 and p85/p110-Phosphatidylinositol 3–kinase by G/CCKBReceptors
- Signaling through the EBV/C3d receptor (CR2, CD21) in human B lymphocytes: activation of Phosphatidylinositol 3–kinase via a CD19-independent pathway
- Cloning of human p55γ, a regulatory subunit of Phosphatidylinositol 3–kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor
- Angiotensin II induces activation of Phosphatidylinositol 3–kinase in cardiomyocytes
- Involvement of Phosphatidylinositol 3′‐kinase in stem‐cell‐factor‐induced phospholipase D activation and arachidonic acid release
- CD45-induced tumor necrosis factor α production in monocytes is Phosphatidylinositol 3–kinase-dependent and nuclear factor-κB-independent
- Wortmannin, a Phosphatidylinositol 3–kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells.
- Phosphatidylinositol 3–kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT …
- Endothelin-1-induced GLUT4 translocation is mediated via Gαq/11 protein and Phosphatidylinositol 3–kinase in 3T3-L1 adipocytes
- N-Methyl-D-aspartate inhibits apoptosis through activation of Phosphatidylinositol 3–kinase in cerebellar granule neurons: a role for insulin receptor substrate …
- Phosphatidylinositol 3‐kinase binds to profilin through the p85α subunit and regulates cytoskeletal assembly
- HMG-CoA reductase inhibitor-induced L6 myoblast cell death: involvement of the Phosphatidylinositol 3–kinase pathway
- Requirement for Ras and Phosphatidylinositol 3–kinase signaling uncouples the glucocorticoid-induced junctional organization and transepithelial electrical …
- Cell Interactions with Collagen Matrices In Vivo and In Vitro Depend on Phosphatidylinositol 3–kinase and Free Cytoplasmic Calcium
- Affinity modulation of very late antigen-5 through Phosphatidylinositol 3–kinase in mast cells
- Tyrosine phosphorylation of the CD3-ε subunit of the T cell antigen receptor mediates enhanced association with Phosphatidylinositol 3–kinase in Jurkat T …
- Platelet-derived growth factor inhibits insulin stimulation of insulin receptor substrate-1-associated Phosphatidylinositol 3–kinase in 3T3-L1 adipocytes without …
- … choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and Phosphatidylinositol 3′-kinase through an extracellular site …
- Functional cooperation of the interleukin-2 receptor β chain and Jak1 in Phosphatidylinositol 3–kinase recruitment and phosphorylation
- … Factor–Activated Signaling Pathways in Human Neutrophils. I. Tyrosine Phosphorylation-Dependent Stimulation of Phosphatidylinositol 3–kinase and Inhibition by …
- Insulin receptor substrate-1 and Phosphatidylinositol 3–kinase regulate extracellular signal-regulated kinase-dependent and-independent signaling pathways during …
- Binding of receptor-recognized forms of α2-macroglobulin to the α2-macroglobulin signaling receptor activates Phosphatidylinositol 3–kinase
- … HT-29 cells is independent of nitric oxide formation: evidence for an interleukin-13-driven Phosphatidylinositol 3–kinase-dependent survival mechanism
- Involvement of protein tyrosine kinase p72syk and Phosphatidylinositol 3–kinase in CD2-mediated granular exocytosis in the natural killer cell line, NK3. 3.
- Expression of Phosphatidylinositol 3–kinase during EGF-Stimulated Wound Repair in Rabbit Corneal Epithelium
- Insulin-like growth factor-1 stimulates rat prolactin gene expression by a Ras, ETS and Phosphatidylinositol 3–kinase dependent mechanism
- SHP-1 associates with both platelet-derived growth factor receptor and the p85 subunit of Phosphatidylinositol 3–kinase
- CD72‐mediated B cell activation involves recruitment of CD19 and activation of Phosphatidylinositol 3‐kinase
- Action of insulin on the surface morphology of hepatocytes: role of Phosphatidylinositol 3–kinase in insulin-induced shape change of microvilli
- Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and Phosphatidylinositol 3–kinase
- … factor of src-and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells: Phosphatidylinositol 3′-kinase is a critical …
- Identification and chromosome assignment of a human gene encoding a novel Phosphatidylinositol–3 kinase
- Phosphatidylinositol 3′-kinase, but not S6-kinase, is required for insulin-like growth factor-I and IL-4 to maintain expression of Bcl-2 and promote survival of myeloid …
- Epidermal growth factor and insulin-induced deoxyribonucleic acid synthesis in primary rat hepatocytes is Phosphatidylinositol 3–kinase dependent and dissociated …
- … (p125FAK) and paxillin in rat pancreatic acini by a phospholipase C-independent process that depends on Phosphatidylinositol 3–kinase, the small GTP …
- Effects of Phosphatidylinositol–3–kinase inhibitors on degranulation and gene induction in allergically triggered mouse mast cells
- Activation of Phosphatidylinositol 3‘-kinase by insulin-like growth factor-I rescues promyeloid cells from apoptosis and permits their differentiation into granulocytes.
- Epidermal growth factor stimulates phospholipase D independent of phospholipase C, protein kinase C or Phosphatidylinositol–3 kinase activation in immortalized …
- … diphosphotyrosine-containing peptide that mimics activated platelet-derived growth factor receptor β induces oligomerization of Phosphatidylinositol 3–kinase
- Monocytic differentiation of HL-60 cells is characterized by the nuclear translocation of Phosphatidylinositol 3–kinase and of definite Phosphatidylinositol-specific …
- Thapsigargin-induced secretion is dependent on activation of a cholera toxin-sensitive and Phosphatidylinositol–3–kinase-regulated phospholipase D in a mast cell …
- Changes in the mitogen-activated protein kinase and Phosphatidylinositol 3–kinase/Akt signaling associated with the induction of apoptosis.
- IL-2 signaling controls actin organization through Rho-like protein family, Phosphatidylinositol 3–kinase, and protein kinase C-zeta.
- A role for Phosphatidylinositol 3–kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin
- Differential association of Phosphatidylinositol 3–kinase with insulin receptor substrate (IRS)-1 and IRS-2 in human thymocytes in response to IL-7.
- Effect of wortmannin, an inhibitor of Phosphatidylinositol 3–kinase, on the first mitotic divisions of the fertilized sea urchin egg
- Platelet‐Derived Growth Factor Stimulates Sodium‐Dependent Pi Transport in Osteoblastic Cells via Phospholipase Cγ and Phosphatidylinositol 3′‐kinase
- Inhibition of human cardiac fibroblast mitogenesis by blockade of mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase
- Phosphatidylinositol 3–kinase and dynamics of insulin resistance in denervated slow and fast muscles in vivo
- Phosphatidylinositol 4-kinase, but not Phosphatidylinositol 3–kinase, is present in GLUT4-containing vesicles isolated from rat skeletal muscle
- Raf-1 kinase Activation by Angiotensin II in Adrenal Glomerulosa Cells: Roles of Gi, Phosphatidylinositol 3–kinase, and Ca2+ Influx
- The inositol polyphosphate 4-phosphatase forms a complex with Phosphatidylinositol 3–kinase in human platelet cytosol
- … chemokinesis in normal human neutrophils is dependent on D‐glucose concentration and sensitive to inhibitors of tyrosine kinase and Phosphatidylinositol 3‐kinase
- Brain‐derived neurotrophic factor stimulates interactions of Shp2 with Phosphatidylinositol 3‐kinase and Grb2 in cultured cerebral cortical neurons
- Phosphatidylinositol 3–kinase and focal adhesion kinase are early signals in the growth factor–like responses to thrombospondin-1 seen in human vascular smooth …
- Insulin stimulation of K+ uptake in 3T3-L1 fibroblasts involves Phosphatidylinositol 3–kinase and protein kinase C-zeta
- Phosphatidylinositol 3′-kinase and p70s6k are required for insulin but not bisperoxovanadium 1, 10-phenanthroline (bpV (phen)) inhibition of insulin-like …
- … secretagogues activate protein tyrosine phosphorylation and release of arachidonic acid in mast cells via a novel protein kinase C and Phosphatidylinositol 3‐kinase …
- Possible role for Phosphatidylinositol 3–kinase in regulating meiotic maturation of bovine oocytes in vitro
- Insulin receptor substrate (IRS)-1 and IRS-2 are tyrosine-phosphorylated and associated with Phosphatidylinositol 3–kinase in response to brain-derived …
- … C-γ1 renders platelet-derived growth factor β-receptor-expressing cells independent of the Phosphatidylinositol 3–kinase pathway for chemotaxis
- Activation of Phosphatidylinositol 3–kinase is necessary for differentiation of FDC-P1 cells following stimulation of type III receptor tyrosine kinases
- Potentiation of Insulin-Induced Phosphatidylinositol–3 kinase Activity by Phorbol Ester Is Mediated by Protein kinase Cϵ
- Phosphatidylinositol 3–kinase and protein kinase C are required for the inhibition of caspase activity by epidermal growth factor
- Signalling-competent truncated forms of ErbB2 in breast cancer cells: differential regulation by protein kinase C and Phosphatidylinositol 3–kinase
- Involvement of both the tyrosine kinase and the Phosphatidylinositol–3′ kinase signal transduction pathways in the regulation of lipoprotein lipase expression in J774 …
- Role of Phosphatidylinositol 3–kinase in degranulation induced by IgE-dependent and-independent mechanisms in rat basophilic RBL-2H3 (ml) cells
- PDGF-induced glycosaminoglycan synthesis is mediated via Phosphatidylinositol 3–kinase
- … new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-Phosphatidylinositol 3–kinase in human T …
- Phosphatidylinositol 3–kinase mediates heregulin-induced growth inhibition in human epithelial cells.
- Insulin activation of Phosphatidylinositol 3–kinase in human skeletal muscle in vivo
- … is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the Phosphatidylinositol 3′-kinase …
- Phosphatidylinositol 3–kinase inhibitors block aortic smooth muscle cell proliferation in mid-late G1 phase: effect on cyclin-dependent kinase 2 and the inhibitory …
- The Phosphatidylinositol 3–kinase inhibitor wortmannin sensitizes quiescent but not proliferating MG-63 human osteosarcoma cells to radiation
- Contrasting Signaling Pathways of α1A- and α1B-Adrenergic Receptor Subtype Activation of Phosphatidylinositol 3–kinase and Ras in Transfected NIH3T3 Cells
- Granulocyte-macrophage colony-stimulating factor and IL-5 activate mitogen-activated protein kinase through Jak2 kinase and Phosphatidylinositol 3–kinase inhuman …
- Inositide signalling in Chlamydomonas: characterization of a Phosphatidylinositol 3–kinase gene
- Suppression of insulin-stimulated Phosphatidylinositol 3–kinase activity by the β3-adrenoceptor agonist CL316243 in rat adipocytes
- Characterization of a novel tyrosine phosphorylated 100-kDa protein that binds to SHP-2 and Phosphatidylinositol 3′-kinase in myeloid cells
- Differential regulation of insulin receptor substrate-2 and mitogen-activated protein kinase tyrosine phosphorylation by Phosphatidylinositol 3–kinase inhibitors in SH …
- … and protein kinase C in dibutyryl cAMP-differentiated U937 cells is dependent solely on the tyrosine-kinase activated form of Phosphatidylinositol–3–kinase
- … to membrane expansion during growth of cultured embryonic mouse hippocampal neurons: sensitivity to inhibitors of Phosphatidylinositol 3–kinase and other protein …
- LY294002-mediated inhibition of Phosphatidylinositol 3–kinase activity triggers growth inhibition and apoptosis in CD40-triggered Ramos–Burkitt lymphoma B cells
- Oncogenic Ras-induced germinal vesicle breakdown is independent of Phosphatidylinositol 3–kinase in Xenopus oocytes
- The structural requirement of Phosphatidylinositols as substrate of Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase regulates differentiation of H9c2 cardiomyoblasts mainly through the protein kinase B/Akt-independent pathway
- H-ras induces glucose uptake in brown adipocytes in an insulin-and Phosphatidylinositol 3–kinase-independent manner
- Interaction of Wild Type and Dominant-Negative p55PIK Regulatory Subunit of Phosphatidylinositol 3–kinase with Insulin-Like Growth Factor-1 Signaling Proteins
- Activation of S6 kinase in human neutrophils by calcium pyrophosphate dihydrate crystals: protein kinase C-dependent and Phosphatidylinositol–3–kinase …
- EGF activates ErbB-2 and stimulates Phosphatidylinositol 3–kinase in human airway smooth muscle cells
- CD16‐mediated activation of Phosphatidylinositol‐3 kinase (Pl‐3K) in human NK cells involves tyrosine phosphorylation of Cbl and its association with Grb2, Shc …
- Retinoic acid inhibits transformation by preventing Phosphatidylinositol 3–kinase dependent activation of the c-fos promoter
- Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the Phosphatidylinositol 3–kinase
- … of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, Phosphatidylinositol 3–kinase β, and protein …
- Insulin signalling in heart involves insulin receptor substrates-1 and-2, activation of Phosphatidylinositol 3–kinase and the JAK 2-growth related pathway
- Wortmannin blocks goldfish retinal Phosphatidylinositol 3–kinase and neurite outgrowth
- … transcription: involvement of the ligand-binding domain of the glucocorticoid receptor and independence from the Phosphatidylinositol 3–kinase and mitogen-activated …
- Binding of CD4 ligands induces tyrosine phosphorylation of Phosphatidylinositol–3 kinase p110 subunit.
- Involvement of Phosphatidylinositol 3–kinase and mitogen-activated protein kinase pathways in AII-mediated enhanced expression of Gi proteins in vascular smooth …
- … -1–induced cell-cycle progression: involvement of extracellular signal-regulated kinase, protein kinase C, and Phosphatidylinositol 3–kinase at distinct points
- Phosphatidylinositol 3–kinase in myogenesis
- Involvement of Phosphatidylinositol 3–kinase in the mediation of erythropoietin-induced activation of p70S6k
- Liver microsomal glucose-6-phosphatase is competitively inhibited by the lipid products of Phosphatidylinositol 3–kinase
- Interleukin-3 induces association of the protein-tyrosine phosphatase SHP2 and Phosphatidylinositol 3–kinase with a 100-kDa tyrosine-phosphorylated …
- Structural and biochemical evaluation of the interaction of the Phosphatidylinositol 3–kinase p85α Src homology 2 domains with phosphoinositides and …
- Phosphatidylinositol 3–kinase is required for the induction of ornithine decarboxylase in leukemia cells stimulated to growth
- Corneal epithelial wound healing increases the expression but not long lasting activation of the p85a subunit of Phosphatidylinositol–3 kinase
- Wortmannin, a Phosphatidylinositol 3–kinase inhibitor, blocks the assembly of peptide-MHC class II complexes.
- Design of peptidomimetics that inhibit the association of Phosphatidylinositol 3–kinase with platelet-derived growth factor-β receptor and possess cellular activity
- Monocyte adherence induced by lipopolysaccharide involves CD14, LFA-1, and cytohesin-1: regulation by Rho and Phosphatidylinositol 3–kinase
- Inhibition of MG‐63 cell proliferation and PDGF‐stimulated cellular processes by inhibitors of Phosphatidylinositol 3‐kinase
- Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and Phosphatidylinositol 3–kinase
- JNK/SAPK activation by platelet-derived growth factor in A431 cells requires both the phospholipase C-γ and the Phosphatidylinositol 3–kinase signaling pathways of …
- Evidence for Phosphatidylinositol 3–kinase-dependent T cell antigen receptor (TCR) signal transduction
- Effects of Phosphatidylinositol 3–kinase inhibitors, wortmannin and LY294002, on germinal vesicle breakdown (GVBD) in porcine oocytes
- Phosphatidylinositol 3–kinase is not required for recycling of mannose 6-phosphate receptors from late endosomes to the trans-Golgi network.
- Islet transplantation restores normal levels of insulin receptor and substrate tyrosine phosphorylation and Phosphatidylinositol 3–kinase activity in skeletal muscle and …
- Cripto-1 inhibits beta-casein expression in mammary epithelial cells through a p21ras-and Phosphatidylinositol 3‘-kinase-dependent pathway.
- An Insulin-like Growth Factor-mediated, Phosphatidylinositol 3′ kinase-independent Survival Signaling Pathway in β Tumor Cells
- … a patient with severe insulin resistance: association of defective insulin-stimulated glucose transport with impaired Phosphatidylinositol 3–kinase activity in fibroblasts
- Hydrogen peroxide-induced activation of SAPK/JNK regulated by Phosphatidylinositol 3–kinase in Chinese hamster V79 cells
- Synergistic role of the Phosphatidylinositol 3–kinase and mitogen-activated protein kinase cascade in the regulation of insulin receptor trafficking
- Evidence that thrombin-stimulated DNA synthesis in pulmonary arterial fibroblasts involves Phosphatidylinositol 3–kinase-dependent p70 ribosomal S6 kinase …
- Phosphatidylinositol 3′-kinase associates with an insulin receptor substrate-1 serine kinase distinct from its intrinsic serine kinase
- Possibility of Distinct Insulin-Signaling Pathways Beyond Phosphatidylinositol 3–kinase–Mediating Glucose Transport and Lipogenesis
- Insulin‐stimulated cell growth in insulin receptor substrate‐1–deficient ZR‐75‐1 cells is mediated by a Phosphatidylinositol‐3‐kinase–independent pathway
- Down regulation of the expression of the p110, p85 and p55 subunits of Phosphatidylinositol 3–kinase during colon cancer cell anchorage-independent growth.
- c-Src and Phosphatidylinositol 3–kinase are involved in NGF-dependent tyrosine phosphorylation of Shc in PC12 cells
- Is stimulation of class-1 Phosphatidylinositol 3–kinase activity by insulin sufficient to activate pathways involved in glucose metabolism.
- Phenylarsine oxide inhibits insulin activation of Phosphatidylinositol 3′-kinase
- Interaction of insulin receptor substrate-1 (IRS-1) with Phosphatidylinositol 3–kinase: effect of substitution of serine for alanine in potential IRS-1 serine phosphorylation …
- Phosphorylation of the Grb2-and Phosphatidylinositol 3–kinase p85–binding p36/38 by Syk in Lck-Negative T Cells
- Tyrosine phosphorylation of Phosphatidylinositol 3–kinase and of the thromboxane A2 (TXA2) receptor by the TXA2 mimetic I-BOP in A7r5 cells
- … in neonatal rat ventricular myocytes by Ras is mediated by Ral guanine nucleotide dissociation stimulator (Ral. GDS) and Phosphatidylinositol 3–kinase in addition to …
- Effect of Ethanol on Intracellular Vesicular Transport from Golgi to the Apical Cell Membrane: Role of Phosphatidylinositol 3‐kinase and Phospholipase A2 in Golgi …
- Evidence that a kinase distinct from protein kinase C and Phosphatidylinositol 3–kinase mediates ligation-dependent serine/threonine phosphorylation of the T …
- Interleukin-4 (IL-4) induces Phosphatidylinositol 3–kinase (p85) dephosphorylation: implications for the role of SHP-1 in the IL-4-induced signals in human B …
- Inhibition of Kit expression by IL-4 and IL-10 in murine mast cells: role of STAT6 and Phosphatidylinositol 3′-kinase
- Phosphatidylinositol 3–kinase is required for the regulation of hepatitis B surface antigen production and mitogen-activated protein kinase activation by insulin but not …
- Formation of distinct signalling complexes involving Phosphatidylinositol 3‐kinase activity with stimulation of epidermal growth factor or insulin‐like growth factor‐I in …
- Secretory IgA-mediated basophil activation: II. Roles of GTP-binding regulatory proteins and Phosphatidylinositol 3–kinase
- Identification of protein kinase B (PKB) as a Phosphatidylinositol 3, 4, 5-trisphosphate binding protein in Dictyostelium discoideum
- Density dependent elevation of Phosphatidylinositol–3 kinase level in rat 3Y1 cells
- CD40-triggered protein tyrosine phosphorylation on Vav and on Phosphatidylinositol 3–kinase correlates with survival of the Ramos–Burkitt lymphoma B cell line
- Phosphatidylinositol 3–kinase translocation to the nucleus is an early event in the interleukin-1 signalling mechanism in human osteosarcoma Saos-2 cells.
- … and insensitive intracellular signalling pathways in undifferentiated 3T3‐L1 cells stimulated by insulin converge with Phosphatidylinositol 3‐kinase upstream of the …
- Phosphatidylinositol 3′-kinase is associated with a serine kinase that is activated by okadaic acid
- Phosphatidylinositol 3–kinase in Cumulus Cells is Responsible for Meiotic Progression from MI to M II Stage in Porcine Follicular Oocytes
- IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, Phosphatidylinositol 3′-kinase, and Grb2
- … Nucleotide Exchange Factor and Ha-Ras: EVIDENCES FOR A FUNCTION OF Raf-1 AND Phosphatidylinositol 3–kinase UPSTREAM TO Ras
- … in tyrosine phosphorylation of insulin receptor and insulin receptor substrate-1 (IRS-1) and association of p85 subunit of Phosphatidylinositol 3–kinase with IRS-1 after …
- Polymorphism and CH… O interaction of wortmannin, a Phosphatidylinositol 3–kinase inhibitor
- … stimulation lowers the activation threshold and enhances the alloreactivity of cord blood T cells by activating the Phosphatidylinositol 3–kinase pathway and inducing …
- … ) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk (L) or p85 Phosphatidylinositol 3–kinase …
- Role of Phosphatidylinositol 3–kinase in platelet aggregation
- Down‐regulation of LFA‐1‐mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires Phosphatidylinositol‐3‐kinase activity
- Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing Phosphatidylinositol signaling molecules
- … -(Hexadecyloxy)-3 (5)-Methoxybutanephosphonate (C4-PI), Inhibits Epithelial Cell Proliferation and is a Substrate but not an Inhibitor of Phosphatidylinositol 3–kinase
- Up-regulation of Phosphatidylinositol 3–kinase in psoriatic lesions
- … of connexin-43, gap junctional protein, in cumulus cells is regulated by mitogen-activated protein kinase and Phosphatidylinositol 3–kinase during in vitro meiotic …
- Inhibition of Phosphatidylinositol 3–kinase
- 1 , 25-Dihydroxyvitamin D 3–induced Myeloid Cell Differentiation Is Regulated by a Vitamin D Receptor–Phosphatidylinositol 3–kinase Signaling Complex
- Immunocytochemical detection of Phosphatidylinositol 3 kinase in Burkitt lymphoma cells
- Defect in long-term activation of Phosphatidylinositol 3–kinase by insulin in vivo: studies in insulin-resistant hHTg rats
- Hexamethylenebisacetamide modulation of thyroglobulin and protein levels in thyroid cells is not mediated by Phosphatidylinositol–3–kinase: A study with wortmannin
- The regulation and function of Phosphatidylinositol 3–kinase
- A role for Phosphatidylinositol 3–kinase in platelet aggregation
- Activation of the Phosphatidylinositol 3–kinase Serine kinase by 1FN-a’
- Phosphatidylinositol 3–kinase mediates interleukin-l-induced activation of NFB and AP-1 Shrikanth
- Regulation of the p85/p110 Phosphatidylinositol 3–kinase
- Through Phosphatidylinositol 3–kinase in Rat Heart
- Cloning and characterisation of novel isoforms of Phosphatidylinositol 3–kinase
- REGULATION OF CHOLANGIOCYTE CL SECRETION BY Phosphatidylinositol 3–kinase
- Bidirectional Effect of Regulatory Subunits of Phosphatidylinositol 3–kinase Dependent Signalling Pathway
- Role of Phosphatidylinositol 3–kinase as an effector of Ras
- Mechanism of radiation sensitization by wortmannin, a Phosphatidylinositol–3 kinase inhibitor
- Up-regulation of Phosphatidylinositol 3–kinase in psoriatic lesions
- Activation of Phosphatidylinositol 3–kinase via epidermal growth factor receptor in isolated rat hepatocytes
- Studies of a Phosphatidylinositol 3–kinase complex linked to vesicular trafficking in human cells
- Comparison of insulin and platelet-derived growth factor signaling: focusing on Phosphatidylinositol 3–kinase
- Activation of p70S6K and ERK as well as Akt by Heat Shock and Hyperosmorality Stress is Phosphatidylinositol 3–kinase Dependent
- Inhibition of proliferation by wortmannin through the blokade of Phosphatidylinositol 3–kinase in mast cell line P815
- Antagonists of Phosphatidylinositol 3–kinase block phosphorylation-dependent activation of the leukocyte NADPH oxidase in a cell-free system
- Phosphatidylinositol 3–kinase AND cAMP INVOLVEMENT IN THE GROWTH HORMONE REGULATION OF ION TRANSPORT IN CACO-2 CELLS
- Serendipitous studies in cell signaling: The role of Phosphatidylinositol 3–kinase (PI3K) in signal transduction, identification of new PI3K targets, and the …
- Activation of Phosphatidylinositol 3–kinase by interleukin-13 in colonic epithelial cells: regulation of nitric oxide and apoptosis
- Phosphatidylinositol–3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation.
- Beclin–Phosphatidylinositol 3–kinase complex functions at the trans-Golgi network
- Phosphatidylinositol 3–kinase signaling controls levels of hypoxia-inducible factor
- New role for Shc in activation of the Phosphatidylinositol 3–kinase/Akt pathway
- Regulation of B-cell activation and differentiation by the Phosphatidylinositol 3–kinase and phospholipase Cgamma pathway.
- Phosphatidylinositol 3–kinase/AKT-mediated activation of estrogen receptor α: a new model for anti-estrogen resistance
- Phosphatidylinositol 3–kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
- Tyrosine phosphorylation of p85 relieves its inhibitory activity on Phosphatidylinositol 3–kinase
- A Phosphatidylinositol 3–kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
- The Phosphatidylinositol 3′-kinase p85α gene is an oncogene in human ovarian and colon tumors
- Two Distinct Vps34 Phosphatidylinositol 3–kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae
- Regulation of neutrophil apoptosis: a role for protein kinase C and Phosphatidylinositol–3–kinase
- Ischemic preconditioning activates Phosphatidylinositol–3–kinase upstream of protein kinase C
- Role of Phosphatidylinositol 3–kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis
- Phosphatidylinositol 3–kinase signaling inhibits DAF-16 DNA binding and function via 14-3–3-dependent and 14-3–3-independent pathways
- Phosphatidylinositol 3–kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis
- Phosphatidylinositol 3‐kinase mediates neuroprotection by estrogen in cultured cortical neurons
- Anti-apoptotic signaling by hepatocyte growth factor/Met via the Phosphatidylinositol 3–kinase/Akt and mitogen-activated protein kinase pathways
- Phosphatidylinositol 3–kinase regulates Raf1 through Pak phosphorylation of serine 338
- Transforming ability of MEN2A-RET requires activation of the Phosphatidylinositol 3–kinase/AKT signaling pathway
- Phosphatidylinositol 3–kinase as a mediator of TNF-induced NF-κB activation
- Expression of constitutively active Phosphatidylinositol 3–kinase inhibits activation of caspase 3 and apoptosis of cardiac muscle cells
- In Vivo and in Vitro Ovarian Carcinoma Growth Inhibition by a Phosphatidylinositol 3–kinase Inhibitor (LY294002)
- Opposing actions of Phosphatidylinositol 3‐kinase and glycogen synthase kinase‐3β in the regulation of HSF‐1 activity
- Phosphatidylinositol 3–kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration
- Substrate specificity of αvβ3integrin-mediated cell migration and Phosphatidylinositol 3–kinase/AKT pathway activation
- Role of reactive oxygen species and Phosphatidylinositol 3–kinase in cardiomyocyte differentiation of embryonic stem cells
- Phosphatidylinositol 3–kinase/Akt activity regulates c-FLIP expression in tumor cells
- The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the Phosphatidylinositol 3–kinase/protein kinase B pathway
- The Phosphatidylinositol 3–kinase/AKT kinase pathway in multiple myeloma plasma cells: roles in cytokine-dependent survival and proliferative responses
- Myotubularin, a phosphatase deficient in myotubular myopathy, acts on Phosphatidylinositol 3–kinase and Phosphatidylinositol 3-phosphate pathway
- Insulin-like growth factor-mediated muscle differentiation: collaboration between Phosphatidylinositol 3–kinase-Akt-signaling pathways and myogenin
- The β2-Adrenergic Receptor Delivers an Antiapoptotic Signal to Cardiac Myocytes Through Gi-Dependent Coupling to Phosphatidylinositol 3′-kinase
- Phosphatidylinositol 3–kinase activity in epidermal growth factor-stimulated matrix metalloproteinase-9 production and cell surface association
- The osteopontin-CD44 survival signal involves activation of the Phosphatidylinositol 3–kinase/Akt signaling pathway
- Latent membrane protein 2A-mediated effects on the Phosphatidylinositol 3–kinase/Akt pathway
- The p75 neurotrophin receptor activates Akt (protein kinase B) through a Phosphatidylinositol 3–kinase-dependent pathway
- Pancreatic cancer cell proliferation is Phosphatidylinositol 3–kinase dependent
- Lipoarabinomannan from Mycobacterium tuberculosis promotes macrophage survival by phosphorylating Bad through a Phosphatidylinositol 3–kinase/Akt …
- Kit/stem cell factor receptor-induced activation of Phosphatidylinositol 3′-kinase is essential for male fertility
- Hypoxia activates a platelet-derived growth factor receptor/Phosphatidylinositol 3–kinase/Akt pathway that results in glycogen synthase kinase–3 inactivation
- Insulin rescues retinal neurons from apoptosis by a Phosphatidylinositol 3–kinase/Akt-mediated mechanism that reduces the activation of caspase-3
- Regulation of the protein kinase Raf-1 by oncogenic Ras through Phosphatidylinositol 3–kinase, Cdc42/Rac and Pak
- BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the Phosphatidylinositol 3–kinase/AKT pathway
- A novel role for Phosphatidylinositol 3–kinase β in signaling from G protein-coupled receptors to Akt
- Platelet-derived growth factor-induced H2O2 production requires the activation of Phosphatidylinositol 3–kinase
- Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/Phosphatidylinositol 3–kinase/PTEN/AKT/FRAP pathway in human prostate …
- Regulation of melanogenesis through Phosphatidylinositol 3–kinase-Akt pathway in human G361 melanoma cells
- Hypoxia induces the activation of the Phosphatidylinositol 3–kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis
- Cytokines promote motoneuron survival through the Janus kinase-dependent activation of the Phosphatidylinositol 3–kinase pathway
- Nucleophosmin–anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the Phosphatidylinositol 3–kinase/Akt antiapoptotic signaling …
- A Phosphatidylinositol 3–kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor …
- Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant
- α7 nicotinic receptor transduces signals to Phosphatidylinositol 3–kinase to block A β-amyloid-induced neurotoxicity
- The bile acid taurochenodeoxycholate activates a Phosphatidylinositol 3–kinase-dependent survival signaling cascade
- The hepatitis B virus-X protein activates a Phosphatidylinositol 3–kinase-dependent survival signaling cascade
- Phosphorylation of PDE3B by Phosphatidylinositol 3–kinase associated with the insulin receptor
- Phosphatidylinositol 3–kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human …
- A specific function for Phosphatidylinositol 3–kinase α (p85α-p110α) in cell survival and for Phosphatidylinositol 3–kinase β (p85α-p110β) in de novo DNA synthesis of …
- Stimulation of Phosphatidylinositol 3–kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
- Overexpression of Phosphatidylinositol 3–kinase in human lung cancer
- Angiopoietin-1 regulates endothelial cell survival through the Phosphatidylinositol 3′-kinase/Akt signal transduction pathway
- Restricted accumulation of Phosphatidylinositol 3–kinase products in a plasmalemmal subdomain during Fcγ receptor-mediated phagocytosis
- Inhibition of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis
- Role of Phosphatidylinositol 3–kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest
- Roles of Phosphatidylinositol 3–kinase in interferon-γ-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression
- Phosphatidylinositol 3–kinase is required for insulin-like growth factor-I–induced vascular smooth muscle cell proliferation and migration
- Association of Phosphatidylinositol 3–kinase with nuclear transcription sites in higher plants
- A novel positive feedback loop mediated by the docking protein Gab1 and Phosphatidylinositol 3–kinase in epidermal growth factor receptor signaling
- Human cytomegalovirus up-regulates the Phosphatidylinositol 3–kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling
- … endothelial growth factor induces expression of connective tissue growth factor via KDR, Flt1, and Phosphatidylinositol 3–kinase-akt-dependent pathways in …
- Signaling complexes and protein-protein interactions involved in the activation of the Ras and Phosphatidylinositol 3–kinase pathways by the c-Ret receptor …
- Hepatitis B virus X protein inhibits transforming growth factor-β-induced apoptosis through the activation of Phosphatidylinositol 3–kinase pathway
- Haptotactic migration induced by midkine: involvement of protein-tyrosine phosphatase ζ, mitogen-activated protein kinase, and Phosphatidylinositol 3–kinase
- The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and-independent pathways: roles for Phosphatidylinositol 3–kinase and Raf
- Interferon α/β promotes cell survival by activating nuclear factor κB through Phosphatidylinositol 3–kinase and Akt
- Angiopoietin-2 at high concentration can enhance endothelial cell survival through the Phosphatidylinositol 3′-kinase/Akt signal transduction pathway
- A Phosphatidylinositol 3–kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFκB in human …
- Induction of vascular endothelial growth factor receptors and Phosphatidylinositol 3′-kinase/Akt signaling by global cerebral ischemia in the rat
- … life span of skeletal muscle satellite cells by enhancing g1/s cell cycle progression via the activation of Phosphatidylinositol 3′-kinase/akt signaling pathway
- Phosphatidylinositol 3–kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells
- Adrenomedullin induces endothelium-dependent vasorelaxation via the Phosphatidylinositol 3–kinase/Akt–dependent pathway in rat aorta
- Association of increased Phosphatidylinositol 3–kinase signaling with increased invasiveness and gelatinase activity in malignant gliomas
- Glycogen synthase kinase–3β activity is critical for neuronal death caused by inhibiting Phosphatidylinositol 3–kinase or Akt but not for death caused by nerve …
- The insulin-like growth factor-Phosphatidylinositol 3–kinase-Akt signaling pathway regulates myogenin expression in normal myogenic cells but not in …
- Phosphatidylinositol 3–kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP)
- Inhibition of the Phosphatidylinositol 3–kinase pathway contributes to HT29 and Caco-2 intestinal cell differentiation
- A member of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of Phosphatidylinositol 3–kinase-Akt activation pathway in …
- Human SMG-1, a novel Phosphatidylinositol 3–kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the …
- Redistribution of Bruton’s tyrosine kinase by activation of Phosphatidylinositol 3‐kinase and Rho‐family GTPases
- Parallel and independent regulation of interleukin-3 mRNA turnover by Phosphatidylinositol 3–kinase and p38 mitogen-activated protein kinase
- Phosphatidylinositol 3–kinase C2α contains a nuclear localization sequence and associates with nuclear speckles
- The Phosphatidylinositol 3–kinase/AKT Signal Transduction Pathway Plays a Critical Role in the Expression of p21WAF1/CIP1/SDI1 Induced by Cisplatin and …
- Amino acid-induced translation of TOP mRNAs is fully dependent on Phosphatidylinositol 3–kinase-mediated signaling, is partially inhibited by rapamycin, and is …
- Nerve growth factor functions as a chemoattractant for mast cells through both mitogen-activated protein kinase and Phosphatidylinositol 3–kinase signaling pathways
- Role of Phosphatidylinositol 3′ kinase and a Downstream Pleckstrin Homology Domain–Containing Protein in Controlling Chemotaxis inDictyostelium
- Prevention of Phosphatidylinositol 3′-kinase-Akt survival signaling pathway during topotecan-induced apoptosis
- Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and Phosphatidylinositol 3–kinase/Akt controls cell migration and …
- Oleate activates Phosphatidylinositol 3–kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite …
- Myogenic differentiation requires signalling through both Phosphatidylinositol 3–kinase and p38 MAP kinase
- Insulin-induced actin filament remodeling colocalizes actin with Phosphatidylinositol 3–kinase and GLUT4 in L6 myotubes
- … up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving Phosphatidylinositol 3′-kinase and distinct from that …
- Insulin Activates ATP-Sensitive K+ Channels in Pancreatic β-Cells Through a Phosphatidylinositol 3–kinase–Dependent Pathway
- Interferon-α promotes survival of human primary B-lymphocytes via Phosphatidylinositol 3–kinase
- … acetate induces neutrophil NADPH‐oxidase activity by two separate signal transduction pathways: dependent or independent of Phosphatidylinositol 3‐kinase
- The role of genetic abnormalities of PTEN and the Phosphatidylinositol 3–kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy
- Phosphatidylinositol 3–kinase inhibition enhances human sperm motility
- Extracellular zinc activates p70 S6 kinase through the Phosphatidylinositol 3–kinase signaling pathway
- Cooperative signaling between α6β4integrin and ErbB-2 receptor is required to promote Phosphatidylinositol 3–kinase-dependent invasion
- … -inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor expression and their regulation by the Phosphatidylinositol 3′-kinase/Akt signaling pathway
- α5β1 integrin protects intestinal epithelial cells from apoptosis through a Phosphatidylinositol 3–kinase and protein kinase B–dependent pathway
- Protein kinase C-ζ phosphorylates insulin receptor substrate-1 and impairs its ability to activate Phosphatidylinositol 3–kinase in response to insulin
- Cell cycle protein expression in vascular smooth muscle cells in vitro and in vivo is regulated through Phosphatidylinositol 3–kinase and mammalian target of …
- The EphA8 receptor regulates integrin activity through p110γ Phosphatidylinositol–3 kinase in a tyrosine kinase activity-independent manner
- The tyrosine phosphatase SHP-2 is required for mediating Phosphatidylinositol 3–kinase/Akt activation by growth factors
- Growth hormone induces cellular insulin resistance by uncoupling Phosphatidylinositol 3–kinase and its downstream signals in 3T3-L1 adipocytes
- … : Neuroprotection mediated by glial group‐II metabotropic glutamate receptors requires the activation of the MAP kinase and the Phosphatidylinositol‐3‐kinase …
- Scatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via Phosphatidylinositol 3–kinase-and AKT-dependent pathways
- Cyclic AMP inhibits extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase/Akt pathways by inhibiting Rap1
- The classical progesterone receptor associates with p42 MAPK and is involved in Phosphatidylinositol 3–kinase signaling inXenopus oocytes
- Cbl-b, a RING-type E3 ubiquitin ligase, targets Phosphatidylinositol 3–kinase for ubiquitination in T cells
- The inhibition of Phosphatidylinositol‐3‐kinase induces neurite retraction and activates GSK3
- Inhibitory mechanisms of tea polyphenols on the ultraviolet B-activated Phosphatidylinositol 3–kinase-dependent pathway
- Preconditioning enhanced glucose uptake is mediated by p38 MAP kinase not by Phosphatidylinositol 3–kinase
- Tec kinase signaling in T cells is regulated by Phosphatidylinositol 3–kinase and the Tec pleckstrin homology domain
- Trypanosoma cruzi: Phosphatidylinositol 3–kinase and protein kinase B activation is associated with parasite invasion
- A Phosphatidylinositol 3–kinase docking site in the cytoplasmic tail of the Jaagsiekte sheep retrovirus transmembrane protein is essential for envelope-induced …
- Phosphatidylinositol 3‐kinase and mTOR mediate lipopolysaccharide‐stimulated nitric oxide production in macrophages via interferon‐β
- Epstein-Barr virus immediate-early protein BRLF1 induces the lytic form of viral replication through a mechanism involving Phosphatidylinositol–3 kinase activation
- L-leucine availability regulates Phosphatidylinositol 3–kinase, p70 S6 kinase and glycogen synthase kinase–3 activity in L6 muscle cells: evidence for the involvement …
- Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through Phosphatidylinositol 3–kinase/Akt phosphorylation and Bcl-xL/caspase …
- Role of extracellular signal-regulated kinase and Phosphatidylinositol–3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis
- TNF-α-induced sphingosine 1-phosphate inhibits apoptosis through a Phosphatidylinositol 3–kinase/Akt pathway in human hepatocytes
- Activation of Phosphatidylinositol 3–kinase and Akt bytert-butylhydroquinone is responsible for antioxidant response element-mediated rGSTA2 induction in H4IIE cells
- Erythropoietin regulates vascular smooth muscle cell apoptosis by a Phosphatidylinositol 3 kinase-dependent pathway
- S338 phosphorylation of Raf-1 is independent of Phosphatidylinositol 3–kinase and Pak3
- … factor rapidly increases activity and cell surface expression of the EAAC1 subtype of glutamate transporter through activation of Phosphatidylinositol 3–kinase
- Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of Phosphatidylinositol 3–kinase
- Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon Phosphatidylinositol–3 kinase and mitogen-activated protein …
- TEL-JAK2 mediates constitutive activation of the Phosphatidylinositol 3′-kinase/protein kinase B signaling pathway
- An inhibitory role of the Phosphatidylinositol 3–kinase-signaling pathway in vascular endothelial growth factor-induced tissue factor expression
- … fructose absorption by the extracellular signal-regulated kinase, p38 mitogen-activated kinase and Phosphatidylinositol 3–kinase intracellular signalling pathways …
- c-Src is required for glial cell line-derived neurotrophic factor (GDNF) family ligand-mediated neuronal survival via a Phosphatidylinositol–3 kinase (PI-3K)-dependent …
- … neurotrophic factor (BDNF) induces dendritic targeting of BDNF and tyrosine kinase B mRNAs in hippocampal neurons through a Phosphatidylinositol–3 kinase …
- Urokinase stimulates human vascular smooth muscle cell migration via a Phosphatidylinositol 3–kinase-Tyk2 interaction
- Phosphatidylinositol 3‐kinase and ERK are required for NF‐κB activation but not for phagocytosis
- Phosphatidylinositol 3–kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor
- Quercetin inhibits Shc-and Phosphatidylinositol 3–kinase-mediated c-Jun N-terminal kinase activation by angiotensin II in cultured rat aortic smooth muscle cells
- Differential effects of Phosphatidylinositol 3–kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport
- Regulation of gene expression by glucose in pancreatic β-cells (MIN6) via insulin secretion and activation of Phosphatidylinositol 3′-kinase
- The essential role of Phosphatidylinositol 3–kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element-mediated rGSTA2 …
- Phosphatidylinositol 3–kinase signaling is important for smooth muscle cell replication after arterial injury
- Trypanosoma cruzi trans-sialidase: A potent and specific survival factor for human Schwann cells by means of Phosphatidylinositol 3–kinase/Akt signaling
- C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through Phosphatidylinositol 3–kinase/Akt pathway
- Putative role of the Phosphatidylinositol 3–kinase—Akt signaling pathway in the survival of granulosa cells
- Activation of Phosphatidylinositol–3 kinase (PI-3K) and extracellular regulated kinases (Erk1/2) is involved in muscarinic receptor-mediated DNA synthesis in neural …
- Insulin accelerates inter-endosomal GLUT4 traffic via Phosphatidylinositol 3–kinase and protein kinase B
- The Ras/Phosphatidylinositol 3–kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling …
- A Novel B Lymphocyte–associated Adaptor Protein, Bam32, Regulates Antigen Receptor Signaling Downstream of Phosphatidylinositol 3–kinase
- Involvement of the pathway Phosphatidylinositol–3–kinase/AKT-1 in the establishment of the survival response to ionizing radiation
- Reduction of potassium currents and Phosphatidylinositol 3–kinase-dependent AKT phosphorylation by tumor necrosis factor-α rescues axotomized retinal ganglion …
- Novel role of Phosphatidylinositol 3–kinase in CD28-mediated costimulation
- Hepatocyte growth factor protects cultured rat cerebellar granule neurons from apoptosis via the Phosphatidylinositol‐3 kinase/Akt pathway
- Halenaquinone, a novel Phosphatidylinositol 3–kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells
- Stem cell factor induces Phosphatidylinositol 3′-kinase–dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells
- X-linked inhibitor of apoptosis protein activates the Phosphatidylinositol 3–kinase/Akt pathway in rat granulosa cells during follicular development
- Phosphatidylinositol–3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-I in human hepatic …
- Thapsigargin-induced degranulation of mast cells is dependent on transient activation of Phosphatidylinositol–3 kinase
- Phosphatidylinositol 3–kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary …
- Specific requirement for the p85-p110α Phosphatidylinositol 3–kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells
- Cooperative regulation of Mcl-1 by Janus kinase/stat and Phosphatidylinositol 3–kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed …
- Phosphatidylinositol–3 kinase acts in parallel to the ERK MAP kinase in the FGF pathway during Xenopus mesoderm induction
- Phosphatidylinositol 3′ kinase signaling in mammary tumorigenesis
- Neuregulin rescues PC12-ErbB4 cells from cell death induced by H2O2: regulation of reactive oxygen species levels by Phosphatidylinositol 3–kinase
- Apoptosis suppression by Raf-1 and MEK1 requires MEK-and Phosphatidylinositol 3–kinase-dependent signals
- Insulin regulates alternative splicing of protein kinase C βII through a Phosphatidylinositol 3–kinase-dependent pathway involving the nuclear serine/arginine …
- fMet-Leu-Phe stimulates proinflammatory cytokine gene expression in human peripheral blood monocytes: the role of Phosphatidylinositol 3–kinase
- Retention of PDGFR-β function in mice in the absence of Phosphatidylinositol 3′-kinase and phospholipase Cγ signaling pathways
- Activation of the Ral and Phosphatidylinositol 3′ kinase signaling pathways by the ras-related protein TC21
- The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via Phosphatidylinositol 3–kinase
- Caveolin 1-mediated regulation of receptor tyrosine kinase-associated Phosphatidylinositol 3–kinase activity by ceramide
- Phosphatidylinositol 3–kinase activation and interaction with focal adhesion kinase in Escherichia coli K1 invasion of human brain microvascular endothelial …
- Targets of B-cell antigen receptor signaling: the Phosphatidylinositol 3–kinase/Akt/glycogen synthase kinase–3 signaling pathway and the Rap1 GTPase.
- Regulation of Cyclin D1 Expression and DNA Synthesis by Phosphatidylinositol 3–kinase in Airway Smooth Muscle Cells
- Interleukin‐6 activates Phosphatidylinositol‐3 kinase, which inhibits apoptosis in human prostate cancer cell lines
- Cooperation between STAT5 and Phosphatidylinositol 3–kinase in the IL-3-dependent survival of a bone marrow derived cell line
- Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and Phosphatidylinositol–3 kinase activation
- Phosphatidylinositol 3–kinase-dependent stabilization of α1(I) collagen mRNA in human lung fibroblasts
- GTPases and Phosphatidylinositol 3–kinase are critical for insulin-like growth factor-I-mediated Schwann cell motility
- The role of Phosphatidylinositol 3–kinase and the mitogen-activated protein kinases in insulin-like growth factor-I-mediated effects in vascular endothelial cells
- Thrombopoietin potentiates collagen receptor signaling in platelets through a Phosphatidylinositol 3–kinase–dependent pathway
- Regulation of intracellular trafficking of the EGF receptor by Rab5 in the absence of Phosphatidylinositol 3–kinase activity
- NK cell‐mediated lysis of autologous antigen‐presenting cells is triggered by the engagement of the Phosphatidylinositol 3‐kinase upon ligation of the natural …
- Role of Gab proteins in Phosphatidylinositol 3–kinase activation by thrombopoietin (Tpo)
- Phosphatidylinositol 3–kinase and NF-κB/Rel are at the divergence of CD40-mediated proliferation and survival pathways
- Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and Phosphatidylinositol 3–kinase in the regulation of Mcl-1 …
- … vascular endothelial cells by a phosphatase inhibitor: possible involvement of extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase
- Growth hormone exerts antiapoptotic and proliferative effects through two different pathways involving nuclear factor-κB and Phosphatidylinositol 3–kinase
- Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, Phosphatidylinositol 3–kinase, and Rac
- … agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on Phosphatidylinositol 3–kinase and transcription factor NF …
- Both src-dependent and-independent mechanisms mediate Phosphatidylinositol 3–kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein …
- Regulation of nuclear factor κB transactivation: implication of Phosphatidylinositol 3–kinase and protein kinase C ζ in c-Rel activation by tumor necrosis factor α
- Phosphatidylinositol 3‐kinase and the control of endosome dynamics: new players defined by structural motifs
- … of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of Phosphatidylinositol 3–kinase and cell proliferation
- Tyr612 and Tyr632 in human insulin receptor substrate-1 are important for full activation of insulin-stimulated Phosphatidylinositol 3–kinase activity and translocation of …
- … of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and Phosphatidylinositol 3–kinase activation
- 1α, 25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by Phosphatidylinositol 3–kinase and mediated by the NADPH …
- … effects of morphine in peroxynitrite-induced apoptosis of primary rat neonatal astrocytes: potential involvement of G protein and Phosphatidylinositol 3–kinase (PI3 …
- Phosphatidylinositol 3–kinase–dependent translocation of phospholipase Cγ2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation
- Phosphatidylinositol 3–kinase-dependent extracellular calcium influx is essential for CX3CR1-mediated activation of the mitogen-activated protein kinase …
- Up-regulation of endothelial nitric-oxide synthase promoter by the Phosphatidylinositol 3–kinase γ/Janus kinase 2/MEK-1-dependent pathway
- … domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent Phosphatidylinositol 3′-kinase activation and endothelial cell …
- ErbB2-overexpressing human mammary carcinoma cells display an increased requirement for the Phosphatidylinositol 3–kinase signaling pathway in anchorage …
- Regulatory role of Phosphatidylinositol 3–kinase on TNF-α–Induced cyclooxygenase 2 expression in colonic epithelial cells
- Cytokines prevent dexamethasone-induced apoptosis via the activation of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase pathways in a new …
- The Gab1 docking protein links the b cell antigen receptor to the Phosphatidylinositol 3–kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase
- Phosphatidylinositol 3–kinase mediates integrin-dependent NF-(κ) B and MAPK activation through separate signaling pathways
- Diversification of cardiac insulin signaling involves the p85α/β subunits of Phosphatidylinositol 3–kinase
- The expression of the p85α subunit of Phosphatidylinositol 3–kinase is induced by activation of the peroxisome proliferator-activated receptor γ in human adipocytes
- Stimulation of human neutrophils by chemotactic factors is associated with the activation of Phosphatidylinositol 3–kinase γ
- Roles of insulin receptor substrate-1, Phosphatidylinositol 3–kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in β-cells
- Differential regulation of the Phosphatidylinositol 3–kinase/Akt and p70 S6 kinase pathways by the α1A-adrenergic receptor in rat-1 fibroblasts
- Phosphatidylinositol 3–kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the …
- Src transduces erythropoietin-induced differentiation signals through Phosphatidylinositol 3–kinase
- Glial cell line-derived neurotrophic factor-stimulated Phosphatidylinositol 3–kinase and Akt activities exert opposing effects on the ERK pathway: importance …
- The bile acid–activated Phosphatidylinositol 3–kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes
- Cross-talk between Phosphatidylinositol 3–kinase and sphingomyelinase pathways as a mechanism for cell survival/death decisions
- Reciprocal regulation of glycogen phosphorylase and glycogen synthase by insulin involving Phosphatidylinositol–3 kinase and protein phosphatase-1 in HepG2 cells
- Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of Phosphatidylinositol 3–kinase
- Insulin-like growth factor (IGF) binding protein-3 potentiation of IGF action is mediated through the Phosphatidylinositol–3–kinase pathway and is associated with …
- Glut-1 Translocation in FRTL-5 Thyroid Cells: Role of Phosphatidylinositol 3–kinase and N-Glycosylation
- Persistent activation of Phosphatidylinositol 3–kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 …
- Five isoforms of the Phosphatidylinositol 3‐kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations
- Phosphatidylinositol–3 kinase regulates p21ras activation during IgE-mediated stimulation of human basophils
- Ceramide regulates lipopolysaccharide-induced Phosphatidylinositol 3–kinase and Akt activity in human alveolar macrophages
- Insulin stimulates NHE1 activity by sequential activation of Phosphatidylinositol 3‐kinase and protein kinase C ζ in human erythrocytes
- Evidence for a Functional Association between Phosphatidylinositol 3–kinase and c-src in the Spreading Response of Osteoclasts to Colony-Stimulating Factor-1
- A Specific Role of Phosphatidylinositol 3–kinase γ: A Regulation of Autonomic Ca2+ Oscillations in Cardiac Cells
- Stabilization of cyclin D1 mRNA via the Phosphatidylinositol 3–kinase pathway in MCF-7 human breast cancer cells
- Protein phosphatase 2A and Phosphatidylinositol 3–kinase regulate the activity of Sp1-responsive promoters
- Tyrosine phosphorylation of the p85 subunit of Phosphatidylinositol 3–kinase correlates with high proliferation rates in sublines derived from the Jurkat leukemia
- Constitutively active Phosphatidylinositol 3–kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3
- Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via Phosphatidylinositol 3–kinase and extracellular signal …
- … protein phosphatase by insulin in vascular smooth muscle cells: evaluation of the role of Rho kinase and Phosphatidylinositol–3–kinase-dependent signaling pathways
- Phosphatidylinositol 3′-kinase blocks CD95 aggregation and caspase-8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD95
- Platelet-derived growth factor activates porcine thecal cell Phosphatidylinositol–3–kinase-Akt/PKB and Ras-extracellular signal-regulated kinase-1/2 kinase signaling …
- Insulin-like growth factor I-induced degradation of insulin receptor substrate 1 is mediated by the 26S proteasome and blocked by Phosphatidylinositol 3′-kinase …
- 15-Deoxy-Δ12, 14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through Phosphatidylinositol 3–kinase in vascular smooth muscle …
- Association of Phosphatidylinositol 3–kinase composed of p110β-catalytic and p85-regulatory subunits with the small GTPase Rab5
- Interleukins 4 and 13 increase intestinal epithelial permeability by a Phosphatidylinositol 3–kinase pathway: lack of evidence for STAT 6 involvement
- ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the Phosphatidylinositol 3–kinase
- Intracellular signals that control cell proliferation in mammalian balance epithelia: key roles for Phosphatidylinositol–3 kinase, mammalian target of rapamycin, and S6 …
- Cutting edge: gab2 mediates an inhibitory Phosphatidylinositol 3′-kinase pathway in T cell antigen receptor signaling
- Brain‐derived neurotrophic factor induces excitotoxic sensitivity in cultured embryonic rat spinal motor neurons through activation of the Phosphatidylinositol 3‐kinase …
- Phosphatidylinositol 3–kinase signaling to Akt mediates survival in isolated canine islets of Langerhans
- … (VEGF) receptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through Phosphatidylinositol 3–kinase …
- Involvement of a Phosphatidylinositol 3–kinase–p38 mitogen activated protein kinase pathway in antigen-induced IL-4 production in mast cells
- … growth factor/scatter factor stimulates migration of rat mammary fibroblasts through both mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase/Akt …
- Nerve Growth Factor Uses Ras/ERK and Phosphatidylinositol 3–kinase Cascades to Up-regulate theN-Methyl-d-aspartate Receptor 1 Promoter
- Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the Phosphatidylinositol 3–kinase and mitogen-activated protein kinase …
- A Phosphatidylinositol 3–kinase of Candida albicans influences adhesion, filamentous growth and virulence
- A link between insulin resistance and hyperinsulinemia: inhibitors of Phosphatidylinositol 3–kinase augment glucose-induced insulin secretion from islets of lean, but …
- Requirement of Phosphatidylinositol 3–kinase activity for translocation of exogenous aFGF to the cytosol and nucleus
- In vitro hormone induction of final oocyte maturation in striped bass (Morone saxatilis) follicles is inhibited by blockers of Phosphatidylinositol 3–kinase activity
- Tyrosine kinase-dependent, Phosphatidylinositol 3′-kinase, and mitogen-activated protein kinase-independent signaling pathways prevent lung adenocarcinoma …
- … preproinsulin gene expression and nucleartrans-location of pancreatic duodenum homeobox-1 require activation of Phosphatidylinositol 3–kinase but not p38 …
- Activation of Phosphatidylinositol 3‐kinase by a complex of p59fyn and the receptor tyrosine kinase Xmrk is involved in malignant transformation of pigment cells
- … protein-5 helps accelerate progression to androgen-independence in the human prostate LNCaP tumor model through activation of Phosphatidylinositol 3′-kinase …
- Dual Signaling via Protein kinase C and Phosphatidylinositol 3′-kinase/Akt Contributes to Bradykinin B2Receptor-induced Cardioprotection in Guinea Pig Hearts
- Insulin-like growth factor I potentiates kainate receptors through a Phosphatidylinositol 3–kinase dependent pathway
- Regulation of Id2 gene expression by the insulin-like growth factor I receptor requires signaling by Phosphatidylinositol 3–kinase
- Basic fibroblast growth factor stimulates surface expression and activity of Na+/H+ exchanger NHE3 via mechanism involving Phosphatidylinositol 3–kinase
- Aggretin, a C-type lectin protein, induces platelet aggregation via integrin α2β1 and GPIb in a Phosphatidylinositol 3–kinase independent pathway
- A molecular basis for T cell suppression by IL‐10: CD28‐associated IL‐10 receptor inhibits CD28 tyrosine phosphorylation and Phosphatidylinositol 3‐kinase binding
- Regulation of oxidative stress-induced calcium release by Phosphatidylinositol 3–kinase and Bruton’s tyrosine kinase in B cells
- Cyclooxygenase-2 inducing Mcl-1-dependent survival mechanism in human lung adenocarcinoma CL1. 0 cells: involvement of Phosphatidylinositol 3–kinase …
- Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished Phosphatidylinositol 3–kinase activation
- … and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, Phosphatidylinositol 3–kinase, and mitogen-activated …
- Role of Phosphatidylinositol 3–kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinase
- The expression of the γ subunit of Na-K-ATPase is regulated by osmolality via C-terminal Jun kinase and Phosphatidylinositol 3–kinase-dependent mechanisms
- Ras activation of Phosphatidylinositol 3–kinase and Akt
- Involvement of Phosphatidylinositol 3–kinase and mitogen-activated protein kinases in glycine-extended gastrin-induced dissociation and migration of gastric …
- Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain of p85α activates Phosphatidylinositol 3–kinase in C2C12 cells
- Regulation of epidermal growth factor receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of Phosphatidylinositol 3–kinase
- The insulin receptor substrate (IRS)-1 recruits Phosphatidylinositol 3–kinase to Ret: evidence for a competition between Shc and IRS-1 for the binding to Ret
- Activation of the Phosphatidylinositol 3–kinase-Akt/protein kinase B signaling pathway in arachidonic acid-stimulated human myeloid and endothelial cells …
- An SH2-domain-containing kinase negatively regulates the Phosphatidylinositol–3 kinase pathway
- The Phosphatidylinositol 3–kinase pathway selectively controls sIL-1RA not interleukin-1β production in the septic leukocytes
- T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of Phosphatidylinositol 3–kinase (p85) via a complex mechanism …
- Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of Phosphatidylinositol 3–kinase and Akt in Chinese hamster ovary cells …
- The T cell antigen receptor activates Phosphatidylinositol 3‐kinase‐regulated serine kinases protein kinase B and ribosomal S6 kinase 1
- Rac and Phosphatidylinositol 3–kinase regulate the protein kinase B in FcεRI signaling in RBL 2H3 mast cells
- Activation of Phosphatidylinositol 3 kinase by muscarinic receptors in astrocytoma cells
- … with Thyrotropin-induced G1-S Transition Mediated by cAMP-dependent Protein kinase and Phosphatidylinositol 3–kinase: INVOLVEMENT OF RhoA AND …
- Expression of a constitutively active form of Phosphatidylinositol 3–kinase inhibits the induction of nitric oxide synthase in human astrocytes
- Role of Phosphatidylinositol 3–kinase in anti-IgM-and anti-IgD-induced apoptosis in B cell lymphomas
- Insulin-mediated cell proliferation and survival involve inhibition of c-Jun N-terminal kinases through a Phosphatidylinositol 3–kinase-and mitogen-activated protein …
- Enteric neuroblasts require the Phosphatidylinositol 3‐kinase pathway for GDNF‐stimulated proliferation
- The CK2 phosphorylation of vitronectin: Promotion of cell adhesion via the αvβ3–Phosphatidylinositol 3–kinase pathway
- β-Adrenergic stimulation of rat cardiac fibroblasts promotes protein synthesis via the activation of Phosphatidylinositol 3–kinase
- … 1 fusion protein of the t (6; 8) translocation induces cell survival mediated by mitogen-activated protein kinase and Phosphatidylinositol 3–kinase/Akt/mTOR pathways
- Ca2+-and Phosphatidylinositol 3–kinase-dependent nitric oxide generation in lung endothelial cells in situ with ischemia
- Compartmentalization and insulin-induced translocations of insulin receptor substrates, Phosphatidylinositol 3–kinase, and protein kinase B in rat liver
- Sites of action of protein kinase C and Phosphatidylinositol 3–kinase are distinct in oxidized low density lipoprotein-induced macrophage proliferation
- Role of Phosphatidylinositol–3 kinase and its association with Gab1 in thrombopoietin-mediated up-regulation of platelet function
- Heregulin‐β is especially potent in activating Phosphatidylinositol 3‐kinase in nontransformed human mammary epithelial cells
- Interaction of the insulin receptor β-subunit with Phosphatidylinositol 3–kinase in bovine ROS
- IL‐12 selectively regulates STAT4 via Phosphatidylinositol 3‐kinase and Ras‐independent signal transduction pathways
- Phosphatidylinositol 3–kinase stimulates muscle differentiation by activating p38 mitogen-activated protein kinase
- … rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of Phosphatidylinositol 3–kinase and Akt kinase …
- Epidermal growth factor-induced Phosphatidylinositol 3–kinase activation and DNA synthesis: identification of Grb2-associated binder 2 as the major mediator …
- Platelet‐activating factor activates mitogen‐activated protein kinases through the activation of Phosphatidylinositol 3‐kinase and tyrosine kinase in human eosinophils
- Phosphatidylinositol 3–kinase is required for the trophic, but not the survival-promoting, actions of NGF on sympathetic neurons
- HIV‐1 Tat protein down‐regulates CREB transcription factor expression in PC12 neuronal cells through a Phosphatidylinositol 3‐kinase/AKT/cyclic nucleoside …
- LY 294002, an inhibitor of Phosphatidylinositol 3–kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes
- Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and Phosphatidylinositol 3–kinase
- … apoptosis by crystals of calcium pyrophosphate dihydrate is mediated by the extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase/Akt pathways up …
- Phosphatidylinositol 3–kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream …
- Regulation of p85α Phosphatidylinositol–3–kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells
- The Rho/Rho‐kinase and the Phosphatidylinositol 3‐kinase pathways are essential for spontaneous locomotion of Walker 256 carcinosarcoma cells
- Interactions between Phosphatidylinositol 3–kinase and nitric oxide: explaining the paradox
- The roles of Phosphatidylinositol 3–kinase and protein kinase Cζ for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine …
- Inhibition of Phosphatidylinositol–3 kinase/Akt or mitogen-activated protein kinase signaling sensitizes endothelial cells to TNF-α cytotoxicity
- Activation of the Phosphatidylinositol 3–kinase/Akt pathway protects against interleukin-3 starvation but not DNA damage-induced apoptosis
- Enhanced cell killing by overexpression of dominant‐negative Phosphatidylinositol 3‐kinase subunit, Δp85, following genotoxic stresses
- … is required for efficient induction of chronic myeloid leukemia–like disease in mice but not for lymphoid leukemogenesis or activation of Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase activity regulates α-thrombin-stimulated G1 progression by its effect on cyclin D1 expression and cyclin-dependent kinase 4 …
- … promotes the expression of peroxisome proliferator-activated receptor γ in vascular smooth muscle cells by a Phosphatidylinositol 3–kinase/Akt signaling pathway
- Mechanism of Phosphatidylinositol 3–kinase-dependent increases in BAC1. 2F5 macrophage-like cell density in response to M-CSF: Phosphatidylinositol 3–kinase …
- … effect of hepatocyte growth factor and fibronectin in anchorage-independent survival of mammary carcinoma cells: requirement for Phosphatidylinositol 3–kinase …
- Interleukin-6 protects rat PC12 cells from serum deprivation or chemotherapeutic agents through the Phosphatidylinositol 3–kinase and STAT3 pathways
- Phosphatidylinositol 3–kinase and Ras/mitogen-activated protein kinase signaling pathways are required for the regulation of 5-aminolevulinate synthase gene …
- Tyrosine kinase and Phosphatidylinositol 3–kinase activation are required for cyclic adenosine 3′, 5′-monophosphate-dependent potentiation of deoxyribonucleic …
- LFA-1-mediated costimulation of CD8+ T cell proliferation requires Phosphatidylinositol 3–kinase activity
- Phosphatidylinositol–3′ kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor
- A Phosphatidylinositol 3‐kinase of Candida albicans: molecular cloning and characterization
- Tyrosine phosphorylation is involved in Phosphatidylinositol 3–kinase activation in bovine rod outer segments
- Phosphatidylinositol 3–kinase-dependent pathways oppose fas-induced apoptosis and limit chloride secretion in human intestinal epithelial cells: implications …
- Phosphatidylinositol 3‐kinase activity is required for the expression of glial fibrillary acidic protein upon cAMP‐dependent induction of differentiation in rat C6 glioma
- Phosphatidylinositol 3–kinase in cumulus cells and oocytes is responsible for activation of oocyte mitogen-activated protein kinase during meiotic progression beyond …
- Neurotrophic factor protection against ethanol toxicity in rat cerebellar granule cell cultures requires Phosphatidylinositol 3–kinase activation
- Phosphatidylinositol 3–kinase activity in murine motoneuron disease: the progressive motor neuropathy mouse
- Phosphatidylinositol 3‐kinase Translocates to the Nucleus of Osteoblast‐Like MC3T3‐E1 Cells in Response to Insulin‐Like Growth Factor I and Platelet‐Derived …
- … a combined treatment with epidermal growth factor and transforming growth factor-β in rat hepatocytes: role of Phosphatidylinositol 3–kinase-induced AP-1 …
- Phosphatidylinositol 3–kinase is required for adherens junction-dependent mammary epithelial cell spheroid formation
- Role of Phosphatidylinositol 3–kinase in acetylcholine-induced dilatation of rat basilar artery
- … growth factor receptor 1 expressed in Xenopus laevis oocytes after fibroblast growth factor 1 addition: Role of Grb2, Phosphatidylinositol 3‐kinase, Src tyrosine kinase …
- Effect of long-term caloric restriction on GLUT4, Phosphatidylinositol–3 kinase p85 subunit, and insulin receptor substrate-1 protein levels in rhesus monkey skeletal …
- Phosphatidylinositol 3–kinase inhibitors, Wortmannin or LY294002, inhibited accumulation of p21 protein after γ-irradiation by stabilization of the protein
- Further evidence for the involvement of insulin receptor substrates in epidermal growth factor‐induced activation of Phosphatidylinositol 3‐kinase
- Rosiglitazone (BRL 49653) enhances insulin secretory response via Phosphatidylinositol 3–kinase pathway
- Anchorage-independent activation of mitogen-activated protein kinase through Phosphatidylinositol–3 kinase by insulin-like growth factor I
- Regulation of gene expression during severe caloric restriction: lack of induction of p85alpha Phosphatidylinositol 3–kinase mRNA in skeletal muscle of patients with …
- Tyrosine phosphorylation of the catalytic subunit p110 of Phosphatidylinositol–3 kinase induced by HMG-CoA reductase inhibitor inhibits its kinase activity in …
- Hepatocyte growth factor-induced differential activation of phospholipase Cγ1 and Phosphatidylinositol 3–kinase is regulated by tyrosine phosphatase SHP-1 …
- MIP-1α induces activation of Phosphatidylinositol–3 kinase that associates with Pyk-2 and is necessary for B-cell migration
- Phosphatidylinositol–3–kinase activation and atypical protein kinase C ζ phosphorylation characterize the DMSO signalling in erythroleukemia cells
- Inhibition of Phosphatidylinositol 3–kinase and protein kinase C attenuates extracellular matrix protein-induced vascular smooth muscle cell chemotaxis
- Phosphatidylinositol 3‐kinase inhibitors prevent mouse cytotoxic T‐cell development in vitro
- Phosphatidylinositol 3′-kinase-mediated calcium mobilization regulates chemotaxis in phosphatidic acid-stimulated human neutrophils
- Membrane depolarization-mediated survival of sympathetic neurons occurs through both Phosphatidylinositol 3–kinase-and CaM kinase II-dependent pathways
- Involvement of insulin receptor substrates in epidermal growth factor induced activation of Phosphatidylinositol 3‐kinase in rat hepatocyte primary culture
- Surfactant protein A regulates pulmonary surfactant secretion via activation of Phosphatidylinositol 3–kinase in type II alveolar cells
- Subcellular localization of insulin receptor substrate family proteins associated with Phosphatidylinositol 3–kinase activity and alterations in lipolysis in primary mouse …
- Phosphatidylinositol 3–kinase in zymosan-and bacteria-induced signalling to mobilisation of arachidonic acid in macrophages
- A human class II MHC–derived peptide antagonizes Phosphatidylinositol 3–kinase to block IL-2 signaling
- Induction of Phosphatidylinositol 3–kinase and serine-threonine kinase-like immunoreactivity in rabbit spinal cord after transient ischemia
- Phosphorylation of unnatural Phosphatidylinositols with Phosphatidylinositol 3–kinase
- Hepatic glutamine transporter activation in burn injury: role of amino acids and Phosphatidylinositol–3–kinase
- VCAM-1 activates Phosphatidylinositol 3–kinase and induces p120Cbl phosphorylation in human airway smooth muscle cells
- Inhibition of Phosphatidylinositol 3–kinase or Mitogen-Activated Protein kinase kinase Leads to Suppression of p34cdc2 kinase Activity and Meiotic Progression …
- DNA Damage-Induced G1 Arrest in Hematopoietic Cells Is Overridden following Phosphatidylinositol 3–kinase-Dependent Activation of Cyclin-Dependent kinase 2
- Phosphatidylinositol 3–kinase and trypsin activation in pancreatitis
- Expression of a prenylation-deficient Rab4 inhibits the GLUT4 translocation induced by active Phosphatidylinositol 3–kinase and protein kinase B
- … induction of tissue inhibitors of metalloproteinase-1 expression and secretion is mediated by mitogen-activated protein kinase and Phosphatidylinositol 3–kinase …
- Interaction of oestrogen receptor with the regulatory subunit of Phosphatidylinositol–3-OH kinase
- A direct interaction between oncogenic Ha-Ras and Phosphatidylinositol 3–kinase is not required for Ha-Ras-dependent transformation of epithelial cells
- … IV Collagen Interacts with a Novel Binding Site on the β3Subunit of Integrin αvβ3 and Stimulates Focal Adhesion kinase and Phosphatidylinositol 3–kinase …
- … 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated aryl hydrocarbon receptor transformation and CYP1A1 induction by the Phosphatidylinositol 3–kinase inhibitor 2-(4 …
- The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and Phosphatidylinositol 3–kinase
- Regulation of human neutrophil‐mediated cartilage proteoglycan degradation by Phosphatidylinositol‐3‐kinase
- … of the C/EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, Phosphatidylinositol 3–kinase, and mammalian target of …
- Modulation of the basal activity of Phosphatidylinositol–3–kinase/protein kinase B signaling pathway in human hepatocarcinoma cells.
- Cytokine-stimulated T cells induce macrophage IL-10 production dependent on Phosphatidylinositol 3–kinase and p70S6K: implications for rheumatoid …
- Phosphatidylinositol 3–kinase in bovine lens and its stimulation by insulin and IGF-1
- Insulin activation of mitogen-activated protein (MAP) kinase and Akt is Phosphatidylinositol 3–kinase-dependent in rat adipocytes
- Inhibition of basophil histamine release by tyrosine kinase and Phosphatidylinositol 3–kinase inhibitors
- Stimulation of glycogen synthesis by insulin requires S6 kinase and Phosphatidylinositol‐3‐kinase in HTC‐IR cells
- Thrombin‐stimulated Phosphatidylinositol 3‐kinase activity in platelets is associated with activation of PYK2 tyrosine kinase: activation of both enzymes is aggregation …
- HIV-Nef enhances interleukin-2 production and Phosphatidylinositol 3–kinase activity in a human T cell line
- Exercise training prevents maturation-induced decreases in insulin receptor substrate-1 and Phosphatidylinositol 3–kinase in rat skeletal muscle
- Involvement of both Phosphatidylinositol 3–kinase and p44/p42 mitogen-activated protein kinase pathways in the short-term regulation of pyruvate kinase L by insulin
- Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of Phosphatidylinositol 3–kinase: no evidence for oxidative inhibition of PTEN
- Gene encoding the catalytic subunit p110beta of human Phosphatidylinositol 3–kinase: cloning, genomic structure, and screening for variants in patients with type 2 …
- CD19 signal transduction in normal human B cells: linkage to downstream pathways requires Phosphatidylinositol 3‐kinase, protein kinase C and Ca2+
- Activation of Phosphatidylinositol 3–kinase by oxidative stress leads to the induction of microsomal epoxide hydrolase in H4IIE cells
- Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates Phosphatidylinositol 3′-kinase binding
- Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and Phosphatidylinositol–3-OH kinase
- Phosphatidylinositol 3–kinase and protein kinase C contribute to the inhibition by interleukin 6 of phosphoenolpyruvate carboxykinase gene expression in cultured rat …
- Protein tyrosine kinase‐dependent regulation of adenylate cyclase and Phosphatidylinositol 3‐kinase activates the expression of glial fibrillary acidic protein upon …
- Odor-stimulated Phosphatidylinositol 3–kinase in lobster olfactory receptor cells
- 3-Deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the Phosphatidylinositol 3–kinase pathway and cancer cell …
- IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and Phosphatidylinositol 3′-kinase
- Roles of Phosphatidylinositol 3‐kinase and phospholipase D in temporal activation of superoxide production in FMLP‐stimulated human neutrophils
- Association of Phosphatidylinositol 3–kinase with the insulin receptor: compartmentation in rat liver
- Prolactin signaling to pim-1 expression: a role for Phosphatidylinositol 3–kinase
- IGF-I stimulates chemotaxis of human neuroblasts. Involvement of type 1 IGF receptor, IGF binding proteins, Phosphatidylinositol–3 kinase pathway and plasmin …
- Interleukin‐10 and interleukin‐13 inhibit proinflammatory cytokine‐induced ceramide production through the activation of Phosphatidylinositol 3‐kinase
- Eicosanoid 12 (S)-HETE activates Phosphatidylinositol 3–kinase
- … receptor (CR2, CD21) on human B lymphocyte surface triggers tyrosine phosphorylation of the 95-kDa nucleolin and its interaction with Phosphatidylinositol 3 kinase
- Expression of Phosphatidylinositol–3 kinase in lung cancer
- Ca2+-evoked serotonin secretion by parafollicular cells: roles in signal transduction of Phosphatidylinositol 3′-kinase, and the γ and ζ isoforms of protein kinase C
- Activation of Phosphatidylinositol 3–kinase is required for transcriptional activity of F-type 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase: assessment of the …
- Dynamin inhibits Phosphatidylinositol 3–kinase in hematopoietic cells
- Evidence for the involvement of Phosphatidylinositol 3–kinase in fMLP-stimulated neutrophil adhesion to ICAM-1-transfected cells
- CRKII participation in the cellular effects of growth hormone and insulin-like growth factor-1: Phosphatidylinositol–3 kinase dependent and independent effects
- … library to identify basic residues in A-Raf required to mediate binding to the Src homology 2 domains of the p85 subunit of Phosphatidylinositol 3′-kinase
- Structural organization of the mouse Phosphatidylinositol 3–kinase p110d gene
- Involvement of tyrosine kinase and Phosphatidylinositol 3–kinase in phagocytosis by ascidian hemocytes
- Phosphatidylinositol 3–kinase modulates IL-18-induced nuclear factor-kappa B activation.
- … -induced glucose transport pathway in 3T3-L1 adipocytes is mediated by gab-1 and requires Gab-1-associated Phosphatidylinositol 3–kinase activity for full …
- Protein kinase C and Phosphatidylinositol 3–kinase independently contribute to P-glycoprotein-mediated drug secretion in the mouse proximal tubule
- Activation of NF-κB binding in HT-29 colon cancer cells by inhibition of Phosphatidylinositol 3–kinase
- Involvement of sphingomyelinase in insulin‐induced Phosphatidylinositol 3‐kinase activation
- Mitogenic signaling by cyclic adenosine monophosphate in chromaffin cells involves Phosphatidylinositol 3‐kinase activation
- … induces eukaryotic initiation factor 4E-binding protein 1 phosphorylation via a Ca2+-dependent pathway independent of Phosphatidylinositol 3–kinase/Akt
- … cascades initiated by fibroblast growth factor 1 on Xenopus oocytes expressing MDA-MB-231 mRNAs: role of Grb2, Phosphatidylinositol 3–kinase, Src tyrosine kinase …
- Activation of phospholipase D in porcine tracheal smooth muscle: role of Phosphatidylinositol 3–kinase and RhoA activation
- Role of the conserved acidic residue Asp21 in the structure of Phosphatidylinositol 3–kinase Src homology 3 domain: circular dichroism and nuclear magnetic …
- Inhibition of Phosphatidylinositol 3–kinase does not alter forskolin-stimulated Cl− secretion by T84 cells
- Modulation of the basal activity of N-acetylglucosaminyltransferase V by Phosphatidylinositol–3–kinase/protein kinase B signaling pathway in human hepatocarcinoma …
- … of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: involvement of Phosphatidylinositol 3–kinase.
- Regulation of the very late antigen‐4‐mediated adhesive activity of normal and nonreleaser basophils: roles for Src, Syk, and Phosphatidylinositol 3‐kinase
- Phosphatidylinositol 3–kinase and prostaglandylinositol cyclic phosphate (cyclic PIP), a mediator of insulin action, in the signal transduction of insulin
- Association of impaired Phosphatidylinositol 3–kinase activity in GLUT1-containing vesicles with malinsertion of glucose transporters into the plasma membrane of …
- Interactions of Phosphatidylinositol 3‐kinase Src homology 3 domain with its ligand peptide studied by absorption, circular dichroism, and UV resonance Raman …
- Cardiac insulin resistance is associated with an impaired recruitment of Phosphatidylinositol 3–kinase to GLUT4 vesicles.
- Glucosamine enhances platelet-derived growth factor-induced DNA synthesis via Phosphatidylinositol 3–kinase pathway in rat aortic smooth muscle cells
- Phosphatidylinositol‐3‐OH kinase regulatory subunits are differentially expressed during development of the rat cerebellum
- Grb-2-Associated Binder-1 Is Involved in Insulin-Induced egr-1 Gene Expression through its Phosphatidylinositol 3′-kinase Binding Site
- Identification of tyrosine residues involved in ligand recognition by the Phosphatidylinositol 3–kinase Src homology 3 domain: Circular dichroism and UV resonance …
- Sensitizing effect of the Phosphatidylinositol 3–kinase inhibitor wortmannin on thermal neutron irradiation with or without boron compound.
- Interleukin-1β Induced Synthesis of Protein kinase C-δ and Protein kinase C-ε in EL4 Thymoma Cells: Possible Involvement of Phosphatidylinositol 3–kinase
- In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires Phosphatidylinositol–3-OH-kinase-dependent and mitogen-activated …
- Ultrastructural modifications and Phosphatidylinositol–3–kinase expression and activity in myocardial tissue deriving from rats in different experimental conditions
- Troglitazone Enhances Glucose Uptake Induced By α‐Adrenoceptor Stimulation Via Phosphatidylinositol 3‐kinase In Rat Heart
- Involvement of regulating the Phosphatidylinositol 3–kinase signaling pathway in the process of herbimycin A-induced erythroid cell differentiation in the K562 …
- Phosphatidylinositol 3–kinase regulates proliferation of RAW 264.7 macrophages
- Regulation of cellular differentiation and cellular function by Phosphatidylinositol 3–kinase
- Up-regulation of Phosphatidylinositol–3 kinase Signaling in plcg1 Gene Null Fibroblasts.
- Tumor Necrosis Factor-α, Sphingomyelinase and Ceramides Activate Tyrosine kinase, P21ras and Phosphatidylinositol 3–kinase: Implications for Glucose Transport …
- Arginine-specific ADP-ribosyltransferase on the surface of gizzard smooth muscle cells and the involvement of Phosphatidylinositol 3–kinase in maintaining the activity …
- Casein kinase I associates with members of the centaurin-α family of Phosphatidylinositol 3, 4, 5-trisphosphate-binding proteins
- Glucose-induced insulin resistance of Phosphatidylinositol 3′-OH kinase and AKT/PKB is mediated by the hexosamine biosynthesis pathway
- TPO regulates Bcl-xL gene expression through Stat5 and Phosphatidylinositol–3–kinase activation pathways
- Wortmannin, A Specific Phosphatidylinositol 3–kinase Inhibitor, Blocks In Vitro Fertilization and Embryonic Development of Bovine Oocytes Matured In Vitro with …
- Activation of Phosphatidylinositol 3–kinase (PI3K) as a predictor of clinical outcome in breast cancer patients
- Phosphatidylinositol 3–kinase and NF
- The cloning and functional characterisation of murine Phosphatidylinositol 3–kinase gamma
- Phosphatidylinositol 3–kinase is involved in IL-18-stimulated AP-1 activation
- Investigation of Phosphatidylinositol–3–kinase (PI3K) and extracellular signal-regulated kinase 1/2 (ERK1/2) activation
- A novel mechanism of regulation of Phosphatidylinositol 3–kinase: Tyrosine phosphorylation of p85 residue 688
- A Role of Phosphatidylinositol 3–kinase (PI3K) on H-ras-lnduced Invasive phenotype
- The role and regulation of Phosphatidylinositol–3 kinase, PTEN, and AKT in tumorigenesis
- Rac and Phosphatidylinositol 3–kinase
- A Role of Phosphatidylinositol 3–kinase (PI3K) on H-ras-Induced Invasive phenotype
- The relationship of Met326Ile variant of p85? regulatory subunit of Phosphatidylinositol 3–kinase (PI3-K) with type 2 diabetes
- Phosphatidylinositol 3-OH kinase–Akt/protein kinase B pathway mediates Gas6 induction of scavenger receptor a in immortalized human vascular smooth muscle cell …
- Activation of Phosphatidylinositol 3–kinase (PI3K) is Required for Invasiveness and Motility in H-ras MCE10A Cells
- The Role of Nuclear Factor kB and Phosphatidylinositol 3–kinase in Trypsinogen Activation in Cerulein-Stimulated Rat Pancreatic Acini
- Phosphatidylinositol 3–kinase BUT NOT TUBERIN IS REQUIRED FOR PDGF-INDUCED CELL MIGRATION
- THE ESSENTIAL ROLE OF Phosphatidylinositol 3–kinase IN THE INDUCTION OF MICROSOMAL EPOXIDE HYDROLASE
- Role of Conserved Acidic Residue Asp21 in the Structure of Phosphatidylinositol 3–kinase Src Homology 3 Domain: Circular Dichroism and Nuclear Magnetic …
- Retinoic acid inhibits transformation by modulating Phosphatidylinositol 3–kinase signaling to the nucleus
- Regulation of hematopoietic cell proliferation by cytokine-activated Phosphatidylinositol 3–kinase
- Involvement of Phosphatidylinositol 3–kinase in the Insulin Signaling in Preimplantation Mouse Embryos
- Regulation of FRTL-5 thyroid cell growth by Phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling
- Expression of Phosphatidylinositol 3–kinase during the proliferation of the hypoxic rat pulmonary arterial smooth muscle cells
- Regulation of lysosomal pH in macrophages via Phosphatidylinositol 3–kinase and protein kinase C
- Activation of Phosphatidylinositol 3–kinase-protein kinase B (PI3K-PKB) induced by 17?-estradiol in endometrial carcinoma cell (Ishikawa)
- Cytokines Prevent Dexamethasone-induced Apoptosis via the Activation of Mitogen-activated Protein kinase and Phosphatidylinositol 3–kinase Pathways in a …
- An Inhibitory Role of the Phosphatidylinositol 3–kinase-signaling Pathway in Vascular Endothelial Growth Factor-induced Tissue Factor Expression
- c-CBL is the bridge molecule linking BCR/ABL to Phosphatidylinositol–3 kinase
- Fas and ceramide inhibition of the Phosphatidylinositol–3–kinase (PI3K) cell survival pathway in human granulosa luteal cells (hGLC).
- The Link between Insulin Resistance and Hyperinsulinemia: Inhibition of Phosphatidylinositol 3–kinase (PI3K) by Wortmannin Augments Glucose (G)-Induced Insulin …
- Wortmannin, A Specific Phosphatidylinositol 3–kinase Inhibitor, Blocks In Vitro Fertilization and Embryonic Development of Bovine Oocytes Matured In Vitro with …
- Lysophosphatidylcholine generates superoxide anions through activation of Phosphatidylinositol 3–kinase in human neutrophils
- Coincident signaling of cAMP with Phosphatidylinositol 3‘kinase and mitogen-activated protein kinase signal transduction cascades: A role in regulating gene …
- The role of nucleoside diphosphate kinase and Phosphatidylinositol 3–kinase in the expression and cellular localization of the glial fibrillary acidic protein …
- Insulin Regulates Alternative Splicing of Protein kinase C ßII through a Phosphatidylinositol 3–kinase-dependent Pathway Involving the Nuclear Serine …
- Evidence for Involvement of Gab-1 Associated Phosphatidylinositol 3–kinase in Osmotic Shock Induced Glucose Transport in 3T3-L1 Adipocytes
- Human SMG-1, a novel Phosphatidylinositol 3–kinase-related protein kinase, associates with components of the mRNA surveillance complex and involved in the …
- Aggretin, a C-Type Lectin Protein, Induces Platelet Aggregation Via Integrin 21 and Gpib in a Phosphatidylinositol 3–kinase Independent Pathway
- Interleukin-1 receptor associated kinase 1 and Phosphatidylinositol 3 kinase regulate the NF-kappaB activation induced by IL-1
- AtPIP5K1, an Arabidopsis thaliana Phosphatidylinositol phosphate kinase, synthesizes PtdIns (3, 4) P2 and PtdIns (4, 5) P2 in vitro and is inhibited by phosphorylation
- Role of the Phosphatidylinositol (PI) 3–kinase/Akt protein kinase signaling pathway in the survival of rat sympathetic neurons
- The Phosphatidylinositol 3–kinase–AKT pathway in human cancer
- Leading the way: directional sensing through Phosphatidylinositol 3–kinase and other signaling pathways
- Prostanoid receptors and Phosphatidylinositol 3–kinase: a pathway to cancer?
- Analysis of the Phosphatidylinositol 3′-kinase Signaling Pathway in Glioblastoma Patients in Vivo
- A crucial role for the p110δ subunit of Phosphatidylinositol 3–kinase in B cell development and activation
- Phosphatidylinositol–3 kinase inhibitors enhance the anti-leukemia effect of STI571
- The Phosphatidylinositol 3–kinase, p38, and extracellular signal-regulated kinase pathways are involved in osteoclast differentiation
- Rapid accumulation of Akt in mitochondria following Phosphatidylinositol 3‐kinase activation
- Inhibition of Phosphatidylinositol 3–kinase enhances mitogenic actions of insulin in endothelial cells
- The Phosphatidylinositol 3–kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria
- Role of the Phosphatidylinositol 3–kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma
- Role of the Phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide
- Anti-cancer alkyl-lysophospholipids inhibit the Phosphatidylinositol 3–kinase–Akt/PKB survival pathway
- The Phosphatidylinositol 3–kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human …
- Inhibition of Phosphatidylinositol 3′-kinase Increases Efficacy of Paclitaxel in in Vitro and in Vivo Ovarian Cancer Models
- Phosphatidylinositol 3–kinase/Akt signaling in the response of vascular endothelium to ionizing radiation
- Role of the Phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells
- Receptor-specific regulation of Phosphatidylinositol 3′-kinase activation by the protein tyrosine phosphatase Shp2
- A Phosphatidylinositol 3–kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding
- Phosphatidylinositol 3‐kinase is involved in Toll‐like receptor 4‐mediated cytokine expression in mouse macrophages
- Src kinase mediates Phosphatidylinositol 3–kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen
- The role of focal adhesion kinase–Phosphatidylinositol 3–kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression
- Inhibition of the Phosphatidylinositol 3′-kinase-AKT Pathway Induces Apoptosis in Pancreatic Carcinoma Cells in Vitro and in Vivo
- Phosphatidylinositol 3–kinase mediates proliferative signals in intestinal epithelial cells
- Phosphatidylinositol 3–kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
- Role of Phosphatidylinositol 3–kinase in oxidative stress-induced disruption of tight junctions
- Targeting the Phosphatidylinositol 3–kinase/Akt pathway for enhancing breast cancer cells to radiotherapy
- Phosphorylation of glycogen synthase kinase–3β during preconditioning through a Phosphatidylinositol–3–kinase–dependent pathway is cardioprotective
- Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase
- Human mammary epithelial cell transformation through the activation of Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms
- Regulation of hypoxia-inducible factor-1α protein level during hypoxic conditions by the Phosphatidylinositol 3–kinase/Akt/glycogen synthase kinase 3β …
- Role of translation initiation factor 2B in control of cell survival by the Phosphatidylinositol 3–kinase/Akt/glycogen synthase kinase 3β signaling pathway
- Constitutively activated Phosphatidylinositol–3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cδ
- Activation of the Phosphatidylinositol 3–kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis
- Involvement of protein kinase C and Phosphatidylinositol 3–kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells
- Phosphatidylinositol 3–kinase/Akt stimulates androgen pathway through GSK3β inhibition and nuclear β-catenin accumulation
- Suppression versus induction of androgen receptor functions by the Phosphatidylinositol 3–kinase/Akt pathway in prostate cancer LNCaP cells with different …
- Mutant epidermal growth factor receptor signaling down-regulates p27 through activation of the Phosphatidylinositol 3–kinase/Akt pathway in glioblastomas
- Normoxic induction of the hypoxia-inducible factor 1α by insulin and interleukin-1β involves the Phosphatidylinositol 3–kinase pathway
- Effects of deguelin on the Phosphatidylinositol 3–kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells
- Native group‐III metabotropic glutamate receptors are coupled to the mitogen‐activated protein kinase/Phosphatidylinositol‐3‐kinase pathways
- … factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and Phosphatidylinositol 3–kinase signaling in colon …
- Phosphatidylinositol 3–kinase Functionally Compartmentalizes the Concurrent Gs Signaling During β2-Adrenergic Stimulation
- Modulation of Rab5 and Rab7 recruitment to phagosomes by Phosphatidylinositol 3–kinase
- Immunocytochemical detection of Phosphatidylinositol 3–kinase activation by insulin and leptin
- Activation of Phosphatidylinositol 3–kinase/Akt pathway by androgen through interaction of p85α, androgen receptor, and Src
- The endothelial receptor tyrosine kinase Tie1 activates Phosphatidylinositol 3–kinase and Akt to inhibit apoptosis
- Phosphatidylinositol 3–kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination
- Phosphatidylinositol 3–kinase: a molecule mediating BDNF-dependent spatial memory formation
- Phosphatidylinositol 3–kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress
- Endurance training improves responsiveness to insulin and modulates insulin signal transduction through the Phosphatidylinositol 3–kinase/Akt-1 pathway
- Activation of the Phosphatidylinositol 3–kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma …
- Inhibition of Phosphatidylinositol 3–kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy
- Src family protein-tyrosine kinases alter the function of PTEN to regulate Phosphatidylinositol 3–kinase/AKT cascades
- Herceptin-induced inhibition of Phosphatidylinositol–3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action
- Microphthalmia associated transcription factor is a target of the Phosphatidylinositol–3–kinase pathway
- Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and Phosphatidylinositol–3 kinase/Akt signaling
- E-cadherin homophilic ligation directly signals through Rac and Phosphatidylinositol 3–kinase to regulate adhesive contacts
- Phosphatidylinositol 3–kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region
- Early expression of myocardial HIF-1α in response to mechanical stresses: regulation by stretch-activated channels and the Phosphatidylinositol 3–kinase signaling …
- Phosphatidylinositol 3–kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1α nor sufficient for HIF-1-dependent target gene transcription
- Phosphatidylinositol 3–kinase redistribution is associated with skeletal muscle insulin resistance in gestational diabetes mellitus
- Phosphatidylinositol 3‐kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones
- Genomic copy number analysis of non-small cell lung cancer using array comparative genomic hybridization: implications of the Phosphatidylinositol 3–kinase …
- Requirement of BMP-2-induced Phosphatidylinositol 3–kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene …
- Phosphatidylinositol 3–kinase regulates the CD4/CD8 T cell differentiation ratio
- Endocytosed transferrin receptors recycle via distinct dynamin and Phosphatidylinositol 3–kinase-dependent pathways
- Insulin activation of Phosphatidylinositol 3–kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia
- Regulation of TRAIL expression by the Phosphatidylinositol 3–kinase/Akt/GSK-3 pathway in human colon cancer cells
- RANKL regulates endothelial cell survival through the Phosphatidylinositol 3′‐kinase/Akt signal transduction pathway
- Characterization of the Met326Ile variant of Phosphatidylinositol 3–kinase p85α
- Caveolin-induced activation of the Phosphatidylinositol 3–kinase/Akt pathway increases arsenite cytotoxicity
- Protective effect of dopamine D2 agonists in cortical neurons via the Phosphatidylinositol 3 kinase cascade
- Regulation of rat Sertoli cell function by FSH: possible role of Phosphatidylinositol 3–kinase/protein kinase B pathway
- Protective effects of docosahexaenoic acid in staurosporine‐induced apoptosis: involvement of Phosphatidylinositol‐3 kinase pathway
- Respiratory syncytial virus inhibits apoptosis and induces NF-κB activity through a Phosphatidylinositol 3–kinase-dependent pathway
- Role of the Phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell …
- Aldosterone regulates vascular reactivity: short-term effects mediated by Phosphatidylinositol 3–kinase–dependent nitric oxide synthase activation
- ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the Phosphatidylinositol 3–kinase
- Vanadate-induced expression of hypoxia-inducible factor 1α and vascular endothelial growth factor through Phosphatidylinositol 3–kinase/Akt pathway and …
- Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the Phosphatidylinositol 3–kinase pathway
- Critical involvement of the Phosphatidylinositol 3–kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer
- Cannabinoids protect astrocytes from ceramide-induced apoptosis through the Phosphatidylinositol 3–kinase/protein kinase B pathway
- Molecular basis of cell membrane estrogen receptor interaction with Phosphatidylinositol 3–kinase in endothelial cells
- … lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a Phosphatidylinositol 3–kinase/Akt-dependent process
- Kaposi’s sarcoma-associated herpesvirus induces the Phosphatidylinositol 3–kinase-PKC-ζ-MEK-ERK signaling pathway in target cells early during infection …
- C5a delays apoptosis of human neutrophils by a Phosphatidylinositol 3–kinase-signaling pathway
- Phosphatidylinositol 3–kinase activity negatively regulates stability of cyclooxygenase 2 mRNA
- CD40 induces human multiple myeloma cell migration via Phosphatidylinositol 3–kinase/AKT/NF-κB signaling
- Ras mediates radioresistance through both Phosphatidylinositol 3–kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal …
- β1 integrin regulates fibroblast viability during collagen matrix contraction through a Phosphatidylinositol 3–kinase/Akt/protein kinase B signaling pathway
- … growth factor-induced migration of multiple myeloma cells is associated with β1 integrin-and Phosphatidylinositol 3–kinase-dependent PKCα activation
- Activated Gαq inhibits p110α Phosphatidylinositol 3–kinase and Akt
- Regulation of Fas expression by STAT3 and c-Jun is mediated by Phosphatidylinositol 3–kinase-AKT signaling
- Ureteric bud outgrowth in response to RET activation is mediated by Phosphatidylinositol 3–kinase
- … tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive Phosphatidylinositol 3′-kinase/Akt pathway signaling
- The role of Phosphatidylinositol 3‐kinase in neural cell adhesion molecule‐mediated neuronal differentiation and survival
- Reduced activation of Phosphatidylinositol–3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle …
- IL-12 provides proliferation and survival signals to murine CD4+ T cells through Phosphatidylinositol 3–kinase/Akt signaling pathway
- Regulation of Phosphatidylinositol 3–kinase activity and Phosphatidylinositol 3, 4, 5-trisphosphate accumulation by neutrophil priming agents
- Implication of Phosphatidylinositol 3–kinase membrane recruitment in hydrogen peroxide-induced activation of PI3K and Akt
- Phosphatidylinositol 3–kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation
- Phosphatidylinositol 3–kinase Regulates Human Immunodeficiency Virus Type 1 Replication following Viral Entry in Primary CD4+ T Lymphocytes and Macrophages
- CD40-dependent activation of Phosphatidylinositol 3–kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis
- The phospholipase Cγ1-dependent pathway of FcϵRI-mediated mast cell activation is regulated independently of Phosphatidylinositol 3–kinase
- Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 Phosphatidylinositol 3–kinase
- IKKβ and Phosphatidylinositol 3–kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-κB activation …
- The Phosphatidylinositol 3‐kinase inhibitor LY294002 potently blocks Kv currents via a direct mechanism
- Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the Phosphatidylinositol 3–kinase-mediated pathway but …
- … cell motility and nuclear factor κB-mediated secretion of urokinase type plasminogen activator through Phosphatidylinositol 3–kinase/Akt signaling pathways …
- Expression of a mutated form of the p85α regulatory subunit of Phosphatidylinositol 3–kinase in a Hodgkin’s lymphoma-derived cell line (CO)
- Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via Phosphatidylinositol 3′-kinase pathway
- … of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, Phosphatidylinositol 3′-kinase-AKT-dependent pathway
- … gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the Phosphatidylinositol–3 kinase domain and is …
- Inactivation of the antiapoptotic Phosphatidylinositol 3–kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition
- … -1 protects human breast epithelial cells against intrinsic apoptotic cell death via the focal adhesion kinase/Phosphatidylinositol 3–kinase and MAPK signaling …
- Phosphatidylinositol 3‐kinase coordinately activates the MEK/ERK and AKT/NFκB pathways to maintain osteoclast survival
- Negative regulation of Phosphatidylinositol 3–kinase and Akt signalling pathway by PKC
- The role of Phosphatidylinositol 3–kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation
- Dysregulation of Phosphatidylinositol 3‐kinase and downstream effectors in human breast cancer
- Insulin down-regulates insulin receptor substrate-2 expression through the Phosphatidylinositol 3–kinase/Akt pathway
- Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and Phosphatidylinositol 3–kinase/AKT by saturated and polyunsaturated …
- Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and Phosphatidylinositol 3–kinase in the adult rat …
- Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/Phosphatidylinositol 3′-kinase/protein kinase B in prostate …
- A Phosphatidylinositol 3–kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling
- Hepatocyte growth factor induced human trophoblast motility involves Phosphatidylinositol–3–kinase, mitogen-activated protein kinase, and inducible nitric oxide …
- Evidence that SHIP-1 contributes to Phosphatidylinositol 3, 4, 5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3–kinase …
- Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin …
- … hormone-treated astrocytes is mediated by epidermal growth factor/mitogen-activated protein kinase–Phosphatidylinositol 3–kinase pathways and involves …
- Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of Phosphatidylinositol 3–kinase and Akt activity mediating neuronal survival
- Interaction between Nef and Phosphatidylinositol–3–kinase leads to activation of p21-activated kinase and increased production of HIV
- Potential role of Phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA–induced immune activation
- p38 Mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase activities have opposite effects on human neutrophil apoptosis
- Activation of Phosphatidylinositol 3–kinase is important for erythropoietin-induced erythropoiesis from CD34+ hematopoietic progenitor cells
- PTEN and Phosphatidylinositol 3′-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial …
- Phosphatidylinositol 3–kinase and NF-κB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen …
- The Role of Novel Oncogenes Squamous Cell Carcinoma-related Oncogene and Phosphatidylinositol 3–kinase p110α in Squamous Cell Carcinoma of the Oral …
- Signal transduction from N-cadherin increases Bcl-2: regulation of the Phosphatidylinositol 3–kinase/Akt pathway by homophilic adhesion and actin …
- Thrombopoietin regulates Bcl-xL gene expression through Stat5 and Phosphatidylinositol 3–kinase activation pathways
- Parallel Phosphatidylinositol–3 kinase and p42/44 mitogen-activated protein kinase signaling pathways subserve the mitogenic and antiapoptotic actions of insulin-like …
- CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of Phosphatidylinositol 3–kinase, Bcl-xL, and IL-2 expression in …
- TAPP1 and TAPP2 are targets of Phosphatidylinositol 3–kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor
- Evidence that rheumatoid arthritis synovial T cells are similar to cytokine‐activated T cells: involvement of Phosphatidylinositol 3‐kinase and nuclear factor κB …
- Epstein-Barr virus latent membrane protein 1 (LMP1) activates the Phosphatidylinositol 3–kinase/Akt pathway to promote cell survival and induce actin filament …
- Ephrin-B2 induces migration of endothelial cells through the Phosphatidylinositol–3 kinase pathway and promotes angiogenesis in adult vasculature
- Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated Phosphatidylinositol 3–kinase activity in muscle
- Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of β1-integrin and Phosphatidylinositol 3′-kinase/AKT …
- Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-Phosphatidylinositol 3–kinase/Akt signaling pathway by disrupting the association of IRS-1 …
- Synchronous activation of ERK and Phosphatidylinositol 3–kinase pathways is required for collagen and extracellular matrix production in keloids
- EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for Phosphatidylinositol 3–kinase and Vav2
- Epidermal growth factor receptor-dependent, NF-κB-independent activation of the Phosphatidylinositol 3–kinase/Akt pathway inhibits ultraviolet irradiation …
- Sustained Production of H2O2Activates Pro-matrix Metalloproteinase-2 through Receptor Tyrosine kinases/Phosphatidylinositol 3–kinase/NF-κB Pathway
- Insulin stimulates hypoxia-inducible factor 1 through a Phosphatidylinositol 3–kinase/target of rapamycin-dependent signaling pathway
- Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-β by Phosphatidylinositol 3–kinase/Akt-dependent suppression of the …
- … lucidum inhibits spontaneous and Fas‐mediated apoptosis in human neutrophils through activation of the Phosphatidylinositol 3 kinase/Akt signaling pathway
- Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression
- Phosphatidylinositol–3–kinase–Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of …
- … induces an autocrine‐paracrine survival pathway via platelet‐derived growth factor (PDGF)‐B/PDGF‐β receptor/Phosphatidylinositol 3‐kinase/Akt signaling in RN46A …
- Characterization of Phosphatidylinositol 3–kinase-dependent phosphorylation of the hydrophobic motif site Thr389 in p70 S6 kinase 1
- Insulin-Like Growth Factor-1–Induced Phosphorylation of Transcription Factor FKHRL1 Is Mediated by Phosphatidylinositol 3–kinase/Akt kinase and Role of This …
- Selective PDZ protein-dependent stimulation of Phosphatidylinositol 3–kinase by the adenovirus E4-ORF1 oncoprotein
- … endothelial growth factor induces protein kinase C (PKC)-dependent Akt/PKB activation and Phosphatidylinositol 3′-kinase-mediated PKCδ phosphorylation: role of …
- Augmentation of sodium butyrate-induced apoptosis by Phosphatidylinositol 3′-kinase inhibition in the KM20 human colon cancer cell line
- Phosphatidylinositol 3–kinase regulates PMA-induced differentiation and superoxide production in HL-60 cells
- … of FcϵRI‐and FcγRI‐mediated degranulation and TNF‐α synthesis in human mast cells: selective utilization of Phosphatidylinositol‐3‐kinase for FcγRI‐induced …
- The oncogene Phosphatidylinositol 3′-kinase catalytic subunit α promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma
- Tauroursodeoxycholic acid prevents amyloid-β peptide-induced neuronal death via a Phosphatidylinositol 3–kinase-dependent signaling pathway
- Functional cooperation among Ras, STAT5, and Phosphatidylinositol 3–kinase is required for full oncogenic activities of BCR/ABL in K562 cells
- … expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1α stabilization: a role for Phosphatidylinositol 3′-kinase
- Involvement of Phosphatidylinositol 3–kinase γ in neutrophil apoptosis
- Activation of Phosphatidylinositol 3–kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic β-cell death
- Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of Phosphatidylinositol 3–kinase, independent of insulin …
- The Phosphatidylinositol 3–kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells
- Src and Phosphatidylinositol 3–kinase mediate soluble E-selectin–induced angiogenesis
- Dietary cod protein restores insulin-induced activation of Phosphatidylinositol 3–kinase/Akt and GLUT4 translocation to the T-tubules in skeletal muscle of high-fat-fed …
- Phosphatidylinositol 3–kinase but not tuberin is required for PDGF-induced cell migration
- Inhibition of Phosphatidylinositol 3–kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis
- The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a Phosphatidylinositol 3–kinase-dependent pathway
- Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves Phosphatidylinositol 3–kinase and reactive oxygen species in …
- The in Vitro and in Vivo Effects of 2-(4-Morpholinyl)-8-phenyl-chromone (LY294002), a Specific Inhibitor of Phosphatidylinositol 3′-kinase, in Human Colon Cancer …
- Essential Role of Phosphatidylinositol 3–kinase-Dependent CCAAT/Enhancer Binding Protein β Activation in the Induction of Glutathione S-Transferase by Oltipraz
- Betacellulin induces angiogenesis through activation of mitogen‐activated protein kinase and Phosphatidylinositol 3‘‐kinase in endothelial cells
- Oncogenic H-Ras Enhances DNA Repair through the Ras/Phosphatidylinositol 3–kinase/Rac1 Pathway in NIH3T3 Cells: Evidence for association with …
- Evidence for Phosphatidylinositol 3–kinase—Akt—p70S6K pathway activation and transduction of mitogenic signals by platelet-derived growth factor in human …
- Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via Phosphatidylinositol 3–kinase/Akt-and MEK1/ERK-dependent …
- The Neuron-Specific Rai (ShcC) Adaptor Protein Inhibits Apoptosis by Coupling Ret to the Phosphatidylinositol 3–kinase/Akt Signaling Pathway
- … expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the Phosphatidylinositol 3–kinase and extracellular signal …
- Phosphatidylinositol 3–kinase Suppresses Glucose-Stimulated Insulin Secretion by Affecting Post-Cytosolic [Ca2+] Elevation Signals
- Requirement for Phosphatidylinositol–3 kinase activity during progression through S-phase and entry into mitosis
- Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a Phosphatidylinositol 3–kinase–dependent pathway in rats
- The effects of lidocaine on the activity of glutamate transporter EAAT3: the role of protein kinase C and Phosphatidylinositol 3–kinase
- β-Arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of Phosphatidylinositol 3–kinase (PI3K) and anti-apoptosis
- Phosphatidylinositol 3–kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites
- Tumor necrosis factor alpha-induced interleukin-8 production via NF-κB and Phosphatidylinositol 3–kinase/Akt pathways inhibits cell apoptosis in human hepatocytes
- IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and Phosphatidylinositol 3–kinase regulation
- … -cytokine cross-talk: the ELR+ CXC chemokine LIX (CXCl5) amplifies a proinflammatory cytokine response via a Phosphatidylinositol 3–kinase-NF-κB pathway
- Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the Phosphatidylinositol 3–kinase pathway in endothelial …
- Nerve growth factor signals through TrkA, Phosphatidylinositol 3–kinase, and Rac1 to inactivate RhoA during the initiation of neuronal differentiation of PC12 …
- Semaphorin 3F antagonizes neurotrophin-induced Phosphatidylinositol 3–kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone …
- Phosphatidylinositol 3–kinase: a key regulator of vascular tone?
- Estrogen regulation of c-fos gene expression through Phosphatidylinositol–3–kinase-dependent activation of serum response factor in MCF-7 breast cancer cells
- Synapsin I-associated Phosphatidylinositol 3–kinase mediates synaptic vesicle delivery to the readily releasable pool
- Putative Phosphatidylinositol 3–kinase (PI3K) binding motifs in ovine betaretrovirus Env proteins are not essential for rodent fibroblast transformation and PI3K/Akt …
- Phosphatidylinositol 3–kinase is essential for the proliferation of lymphoblastoid cells
- Taurolithocholic acid exerts cholestatic effects via Phosphatidylinositol 3–kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets
- The Phosphatidylinositol‐3 kinase (PI3K)‐Akt pathway suppresses neurite branch formation in NGF‐treated PC12 cells
- Involvement of Phosphatidylinositol 3–kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation
- Interferon beta promotes survival in primary astrocytes through Phosphatidylinositol 3–kinase
- Role of Phosphatidylinositol 3–kinase/Akt pathway in angiotensin II and insulin-like growth factor-1 modulation of nitric oxide synthase in vascular smooth muscle cells
- Acetylcholine leads to free radical production dependent on KATP channels, Gi proteins, Phosphatidylinositol 3–kinase and tyrosine kinase
- Hepatitis B virus X protein activates a survival signaling by linking SRC to Phosphatidylinositol 3–kinase
- … sugar absorption is regulated by phosphorylation and turnover of protein kinase C βII mediated by Phosphatidylinositol 3–kinase-and mammalian target of …
- The α5β1 integrin selectively enhances epidermal growth factor signaling to the Phosphatidylinositol–3–kinase/Akt pathway in intestinal epithelial cells
- Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and Phosphatidylinositol 3–kinase pathways
- Phosphatidylinositol 3–kinase and calcium-activated transcription pathways are required for VLDL-induced smooth muscle cell proliferation
- Estrogen enhances depolarization-induced glutamate release through activation of Phosphatidylinositol 3–kinase and mitogen-activated protein kinase in cultured …
- Regulatory role for SRC and Phosphatidylinositol 3–kinase in initiation of fibronectin matrix assembly
- TC21 mediates transformation and cell survival via activation of Phosphatidylinositol 3–kinase/Akt and NF-κB signaling pathway
- … CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and Phosphatidylinositol 3–kinase signaling leading to …
- Necessary role of Phosphatidylinositol 3‐kinase in transforming growth factor β–mediated activation of Akt in normal and rheumatoid arthritis synovial fibroblasts
- … motility and nuclear factor κB-mediated secretion of urokinase type plasminogen activator by inhibiting the Phosphatidylinositol 3′-kinase activity in breast …
- Attenuated 5‐HT1A receptor signaling in brains of suicide victims: involvement of adenylyl cyclase, Phosphatidylinositol 3‐kinase, Akt and mitogen‐activated protein …
- … nitric-oxide synthase by tumor necrosis factor-α: a novel pathway involving sequential activation of neutral sphingomyelinase, Phosphatidylinositol–3′ kinase, and …
- … cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase C, Phosphatidylinositol 3–kinase, and mitogen-activated protein …
- Phosphatidylinositol 3–kinase is a key regulator of early phase differentiation in keratinocytes
- Activation of Protein kinase C-ζ by Insulin and Phosphatidylinositol–3,4,5-(PO4)3 Is Defective in Muscle in Type 2 Diabetes and Impaired Glucose Tolerance …
- Evidence that Phosphatidylinositol 3–kinase-and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent pathways cooperate to …
- Interleukin-3-mediated cell survival signals include Phosphatidylinositol 3–kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface
- … growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and Phosphatidylinositol 3′-kinase-Akt signaling pathways
- Requirement of Phosphatidylinositol 3–kinase activation and calcium influx for leukotriene B4-induced enzyme release
- Studies of the mitogen-activated protein kinases and Phosphatidylinositol–3 kinase in the lens. 1. The mitogenic and stress responses
- The cross-talk between angiotensin and insulin differentially affects Phosphatidylinositol 3–kinase-and mitogen-activated protein kinase-mediated signaling in rat heart …
- Impaired insulin action on Phosphatidylinositol 3–kinase activity and glucose transport in skeletal muscle of pancreatic cancer patients
- Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits Phosphatidylinositol 3–kinase to mediate the tumor necrosis factor-induced angiogenic …
- Phosphatidylinositol 3′-kinase is required for growth of mast cells expressing the kit catalytic domain mutant
- Cell cycle activation in lung adenocarcinoma cells by the ErbB3/Phosphatidylinositol 3–kinase/Akt pathway
- HIV-1-Tat protein activates Phosphatidylinositol 3–kinase/AKT-dependent survival pathways in Kaposi’s sarcoma cells
- Activation of CR3‐mediated phagocytosis by MSP requires the RON receptor, tyrosine kinase activity, Phosphatidylinositol 3‐kinase, and protein kinase C ζ
- Insulin activates CCAAT/enhancer binding proteins and proinflammatory gene expression through the Phosphatidylinositol 3–kinase pathway in vascular …
- Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via Phosphatidylinositol–3–kinase–dependent pathway
- 1α,25-Dihydroxyvitamin D3 Induces Vascular Smooth Muscle Cell Migration via Activation of Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3′-kinase-dependent activation of renal mesangial cell Ki-Ras and ERK by advanced glycation end products
- … -like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome C release and apoptosis via the Phosphatidylinositol 3 kinase/Akt signaling pathway
- Phosphatidylinositol 3–kinase controls antineutrophil cytoplasmic antibodies—induced respiratory burst in human neutrophils
- Follicle-stimulating hormone promotes nuclear exclusion of the forkhead transcription factor FoxO1a via Phosphatidylinositol 3–kinase in porcine granulosa cells
- Role of Phosphatidylinositol 3‐kinase in neuronal survival and axonal outgrowth of adult mouse dorsal root ganglia explants
- μ-opioid receptor activation prevents apoptosis following serum withdrawal in differentiated SH-SY5Y cells and cortical neurons via Phosphatidylinositol 3–kinase
- Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not Phosphatidylinositol 3–kinase: direct evidence of a role for …
- Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, Phosphatidylinositol 3–kinase and protein kinase B in …
- Regulation of the Phosphatidylinositol 3–kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways …
- The role of Phosphatidylinositol 3′-kinase and its downstream signals in erbB-2-mediated transformation
- Distinct role of Phosphatidylinositol 3–kinase and Rho family GTPases in Vav3-induced cell transformation, cell motility, and morphological changes
- … -like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A-and a Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3–kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling
- Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by Phosphatidylinositol 3–kinase inhibitor LY294002
- Role of the insulin receptor substrate 1 and Phosphatidylinositol 3–kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein …
- High-fat diet and leptin treatment alter skeletal muscle insulin-stimulated Phosphatidylinositol 3–kinase activity and glucose transport
- … of interferon-γ-inducible GTPase inhibits coxsackievirus B3-induced apoptosis through the activation of the Phosphatidylinositol 3–kinase/Akt pathway and …
- Transformation of mouse fibroblasts by Jaagsiekte sheep retrovirus envelope does not require Phosphatidylinositol 3–kinase
- Y box-binding protein 1 induces resistance to oncogenic transformation by the Phosphatidylinositol 3–kinase pathway
- … growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3‐kinase is essential for kit ligand‐mediated survival, whereas interleukin‐3 and flt3 ligand induce expression of antiapoptotic Bcl‐2 family …
- Insulin Resistance, Defective Insulin Receptor Substrate 2—Associated Phosphatidylinositol–3′ kinase Activation, and Impaired Atypical Protein kinase C (ζ/λ) …
- Phosphatidylinositol 3–kinase may mediate isoproterenol-induced vascular relaxation in part through nitric oxide production
- Inhibition of activator protein-1 binding activity and Phosphatidylinositol 3–kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue …
- B cell receptor-mediated Syk-independent activation of Phosphatidylinositol 3–kinase, Ras, and mitogen-activated protein kinase pathways
- High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to Phosphatidylinositol (3, 4, 5)-trisphosphate
- Phosphatidylinositol 3–kinase activity is required for epidermal growth factor to suppress proteolysis
- A new role for the p85-Phosphatidylinositol 3–kinase regulatory subunit linking FRAP to p70 S6 kinase activation
- Phosphatidylinositol 3‐kinase and extracellular signal‐regulated kinase are recruited for Fc receptor‐mediated phagocytosis during monocyte‐to‐macrophage …
- Phosphatidylinositol 3–kinase in cumulus cells is responsible for both suppression of spontaneous maturation and induction of gonadotropin-stimulated …
- Inhibition of Phosphatidylinositol 3‐kinase and p70S6 kinase blocks osteogenic protein‐1 induction of alkaline phosphatase activity in fetal rat calvaria cells
- Neuroprotection by scatter factor/hepatocyte growth factor and FGF‐1 in cerebellar granule neurons is Phosphatidylinositol 3‐kinase/akt‐dependent and MAPK/CREB …
- Down-regulation of the Phosphatidylinositol 3–kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional …
- … -mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform: regulation by Phosphatidylinositol 3′-kinase and the actin …
- Stretch-induced retinal vascular endothelial growth factor expression is mediated by Phosphatidylinositol 3–kinase and protein kinase C (PKC)-ζ but not by …
- Antagonism of rat β-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and Phosphatidylinositol 3–kinase …
- Inhibition of Phosphatidylinositol 3‐kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma …
- Up-regulation of Phosphatidylinositol 3–kinase and glucose transporter 4 in muscle of rats subjected to maternal undernutrition
- AKT and the Phosphatidylinositol 3–kinase/AKT pathway: important molecular targets for lung cancer prevention and treatment
- Insulin inhibits extracellular regulated kinase 1/2 phosphorylation in a Phosphatidylinositol 3‐kinase (PI3) kinase‐dependent manner in Neuro2a cells
- Vascular endothelial growth factor causes pulmonary vasodilation through activation of the Phosphatidylinositol–3–kinase-nitric oxide pathway in the late …
- Src-Dependent Association of Cas and p85 Phosphatidylinositol 3′-kinase in v-crk-Transformed Cells
- Differential activation of Phosphatidylinositol 3–kinase signaling during proliferation and differentiation of lens epithelial cells
- … -1-Phosphate and Lysophosphatidic Acid Prevent Apoptosis in Osteoblastic Cells via a Signaling Pathway Involving Gi Proteins and Phosphatidylinositol–3 kinase
- Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: Role of ERK MAP kinase and Phosphatidylinositol 3–kinase β
- Purinergic P2Y12 receptor blockade inhibits shear-induced platelet Phosphatidylinositol 3–kinase activation
- Adrenomedullin reduces VEGF-induced endothelial adhesion molecules and adhesiveness through a Phosphatidylinositol 3′-kinase pathway
- Fibronectin enhances viability and alters cytoskeletal functions (with effects on the Phosphatidylinositol 3‐kinase pathway) in small cell lung cancer
- Phosphatidylinositol 3–kinase-dependent, MEK-independent proliferation in response to CaR activation
- Studies of the mitogen-activated protein kinases and Phosphatidylinositol–3 kinase in the lens. 2. The intercommunications
- Lipid rafts as the signaling scaffold for NK cell activation: tyrosine phosphorylation and association of LAT with Phosphatidylinositol 3‐kinase and phospholipase C‐γ …
- Noncatalytic domain of uPA stimulates human extravillous trophoblast migration by using phospholipase C, Phosphatidylinositol 3–kinase and mitogen-activated …
- Co-activation of the Phosphatidylinositol–3–kinase/Akt signaling pathway by N-methyl-D-aspartate and TrkB receptors in cerebellar granule cell neurons
- 1α, 25-dihydroxyvitamin D3 stimulates activator protein 1 DNA-binding activity by a Phosphatidylinositol 3–kinase/Ras/MEK/extracellular signal regulated …
- Selenite-induced survival of HuH7 hepatoma cells involves activation of focal adhesion kinase–Phosphatidylinositol 3–kinase-Akt pathway and Rac1
- Glucose-induced Phosphatidylinositol 3–kinase and mitogen-activated protein kinase-dependent upregulation of the platelet-derived growth factor-β receptor …
- Synthetic studies of the Phosphatidylinositol 3–kinase inhibitor LY294002 and related analogues
- … from PC12 Cells by Increasing Ca2+-Responsible Secretory Vesicles through the Activation of Mitogen-Activated Protein kinase and Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase regulates bone morphogenetic protein-2 (BMP-2)-induced myocyte enhancer factor 2A-dependent transcription of BMP-2 gene …
- … TCRγδ+ and Vδ2+ TCRγδ+ T lymphocytes from healthy donors and multiple sclerosis patients: Involvement of Phosphatidylinositol 3 kinase and calcium calmodulin …
- Phosphatidylinositol 3–kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells …
- … up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the Phosphatidylinositol 3–kinase/Akt signaling pathway in …
- Pathogenic T cells in murine lupus exhibit spontaneous signaling activity through Phosphatidylinositol 3‐kinase and mitogen‐activated protein kinase pathways
- Growth factor receptor-binding protein 10 (Grb10) as a partner of Phosphatidylinositol 3–kinase in metabolic insulin action
- Phosphatidylinositol 3–kinase p85 adaptor function in T-cells: co-stimulation and regulation of cytokine transcription independent of associated p110
- Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of Phosphatidylinositol 3–kinase: the role of nitric oxide synthase in rat …
- BMP‐2 regulates cardiomyocyte contractility in a Phosphatidylinositol 3 kinase‐dependent manner
- Phosphatidylinositol 3–kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells
- Granulocyte-macrophage colony-stimulating factor signals for increased glucose transport via Phosphatidylinositol 3–kinase-and hydrogen peroxide …
- Autocrine signaling through Ras regulates cell survival activity in human glioma cells: potential cross-talk between Ras and the Phosphatidylinositol 3–kinase-Akt …
- Inhibition of the Phosphatidylinositol 3‘-kinase signaling pathway increases the responsiveness of pancreatic carcinoma cells to sulindac
- … factor/scatter factor inhibits UVB-induced apoptosis of human keratinocytes but not of keratinocyte-derived cell lines via the Phosphatidylinositol 3–kinase/AKT …
- Phosphatidylinositol 3‘-kinase and MAPK/ERK kinase 1/2 differentially regulate expression of vascular endothelial growth factor in human malignant astrocytoma cells
- The Phosphatidylinositol 3–kinase inhibitor LY294002 binds the estrogen receptor and inhibits 17β-estradiol-induced transcriptional activity of an estrogen sensitive …
- Inhibition of lymphocyte kinase Lck and Phosphatidylinositol 3–kinase by a novel immunosuppressant, lymphostin
- Role of Phosphatidylinositol 3‐kinase in the binding of Bordetella pertussis to human monocytes
- Human neutrophil-expressed CD28 interacts with macrophage B7 to induce Phosphatidylinositol 3–kinase-dependent IFN-γ secretion and restriction of Leishmania …
- … of a signature of interferon-γ-induced polypeptides that includes manganese-superoxide dismutase and the p85β subunit of Phosphatidylinositol 3–kinase
- Decay‐accelerating factor induction by tumour necrosis factor‐α, through a Phosphatidylinositol‐3 kinase and protein kinase C‐dependent pathway, protects murine …
- Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal–regulated kinase pathway but not by the Phosphatidylinositol 3–kinase …
- Targeting of Mitogen-Activated Protein kinases and Phosphatidylinositol 3 kinase Inhibits Hepatocyte Growth Factor/Scatter Factor–Induced Angiogenesis
- Preferential binding of Grb2 or Phosphatidylinositol 3–kinase to the met receptor has opposite effects on HGF-induced myoblast proliferation
- Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of Phosphatidylinositol 3–kinase
- … in human basophils by p38 mitogen‐activated protein kinase: phosphorylation is sensitive to the effects of Phosphatidylinositol 3‐kinase inhibitors and calcium …
- Inhibition of nuclear factor κB and Phosphatidylinositol 3‐kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor α in mice
- … induces intracellular accumulation of multivesicular bodies and major histocompatibility complex class II complexes: potential role of Phosphatidylinositol 3–kinase
- Regulatory role of cAMP on expression of Cdk4 and p27Kip1 by inhibiting Phosphatidylinositol 3–kinase in corneal endothelial cells
- … ) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): an alternative Phosphatidylinositol 3–kinase-independent pathway to …
- … acid stimulates DNA synthesis in human microvascular endothelial cells via activation of Jak/STAT and Phosphatidylinositol 3–kinase/Akt signaling, leading to …
- Necessity of tyrosine 719 and Phosphatidylinositol 3′-kinase–mediated signal pathway in constitutive activation and oncogenic potential of c-kit receptor tyrosine …
- Recruitment of Phosphatidylinositol 3–kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism
- Calcium receptor-induced serotonin secretion by parafollicular cells: role of Phosphatidylinositol 3–kinase-dependent signal transduction pathways
- Motility enhancement by tumor-derived mutant E-cadherin is sensitive to treatment with epidermal growth factor receptor and Phosphatidylinositol 3–kinase inhibitors
- Phosphatidylinositol 3–kinase regulates glycosylPhosphatidylinositol hydrolysis through PLC-γ2 activation in erythropoietin-stimulated cells
- A new class of mutations reveals a novel function for the original Phosphatidylinositol 3–kinase binding site
- Involvement of Phosphatidylinositol 3–kinase in nuclear translocation of protein kinase C ζ induced by C2-ceramide in rat hepatocytes
- Enhancement of ischemia‐induced tyrosine phosphorylation of Kv1. 2 by vascular endothelial growth factor via activation of Phosphatidylinositol 3‐kinase
- Involvement of the Src kinase Lyn in phospholipase C-γ2 phosphorylation and Phosphatidylinositol 3–kinase activation in Epo signalling
- … granulocyte–macrophage colony‐stimulating factor and interleukin‐5, inhibits apoptosis of human basophils through Phosphatidylinositol 3‐kinase: requirement of NF …
- Insulin promotes formation of polymerized microtubules by a Phosphatidylinositol 3–kinase-independent, actin-dependent pathway in 3T3-L1 adipocytes
- … (EPO)-induced erythroid differentiation of K562 cells is accompanied by the nuclear translocation of Phosphatidylinositol 3–kinase and intranuclear generation of …
- Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a Phosphatidylinositol 3–kinase-dependent pathway
- β‐Adrenergic receptor‐mediated DNA synthesis in neonatal rat cardiac fibroblasts proceeds via a Phosphatidylinositol 3‐kinase dependent pathway refractory to the …
- Regulation of phospholipase C-γ2 via Phosphatidylinositol 3–kinase in macrophages
- Degradation of IκBα in activated RAW264. 7 cells is blocked by the Phosphatidylinositol 3–kinase inhibitor LY294002
- LY294002, an inhibitor of Phosphatidylinositol–3–kinase, causes preferential induction of apoptosis in human multidrug resistant cells
- Involvement of Phosphatidylinositol–3–kinase in membrane ruffling induced by P-glycoprotein substrates in multidrug-resistant carcinoma cells
- Aspirin protects Caco-2 cells from apoptosis after serum deprivation through the activation of a Phosphatidylinositol 3–kinase/AKT/p21Cip/WAF1pathway
- Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the Phosphatidylinositol–3–kinase pathway in the rat heart
- Insulin‐like growth factor‐1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through Phosphatidylinositol 3‐kinase and MAPK
- Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, Phosphatidylinositol 3‐kinase and extracellular signal regulated …
- Binding of Phosphatidylinositol 3, 4, 5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change
- … -regulates the transcription of mouse lon homology ATP-dependent protease through extracellular signal-regulated protein kinase-and Phosphatidylinositol–3–kinase …
- Phosphatidylinositol 3–kinase-like activity in Tetrahymena. Effects of wortmannin and LY 294002
- Involvement of Phosphatidylinositol 3 kinase in the progesterone-induced oocyte maturation in Rana dybowskii
- Growth arrest of PC12 cells by nerve growth factor is dependent on the Phosphatidylinositol 3‐kinase/Akt pathway via p75 neurotrophin receptor
- … bad and glycogen synthase kinase–3 in a protein kinase A-dependent manner and prevents apoptosis following inhibition of Phosphatidylinositol 3–kinase
- Wortmannin, a specific inhibitor of Phosphatidylinositol–3–kinase influences neurotrophin-induced spiral ganglion neurite growth
- … -activated receptor gamma impedes Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis through Phosphatidylinositol 3–kinase …
- External Qi of Yan Xin life science technology can revive or suppress enzyme activity of Phosphatidylinositol 3–kinase
- Matrix-independent activation of Phosphatidylinositol 3–kinase, Stat3, and cyclin A-associated Cdk2 Is essential for anchorage-independent growth of v-Ros …
- Phosphatidylinositol 3–kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes
- Transient ischemia enhances tyrosine phosphorylation and binding of the NMDA receptor to the Src homology 2 domain of Phosphatidylinositol 3‐kinase in the rat …
- Kit/stem cell factor receptor‐induced Phosphatidylinositol 3′‐kinase signalling is not required for normal development and function of interstitial cells of Cajal in …
- Cytoskeletal reorganization induced by insulin: involvement of Grb2/Ash, Ras and Phosphatidylinositol 3‐kinase signalling
- Selective pharmacological inhibitors reveal the role of Syk tyrosine kinase, phospholipase C, Phosphatidylinositol–3′-kinase, and p38 mitogen-activated protein …
- Phospholipase C and Phosphatidylinositol 3‐kinase signaling are involved in the exogenous arachidonic acid‐stimulated respiratory burst in human neutrophils
- Control of proteolysis by norepinephrine and insulin in brown adipocytes: role of ATP, Phosphatidylinositol 3–kinase, and p70 S6K
- … papillomavirus type 1 nucleotide 3225 3′ splice site can be rescued in a cell lacking splicing factor ASF/SF2 through activation of the Phosphatidylinositol 3–kinase …
- Gene expression of the p85α regulatory subunit of Phosphatidylinositol 3–kinase in skeletal muscle from type 2 diabetic subjects
- Detection of the p110 beta subunit of Phosphatidylinositol 3–kinase complexed with neutral endopeptidase.
- Phosphatidylinositol 3–kinase mediates inhibitory effect of angiotensin II on sodium/glucose cotransporter in renal epithelial cells
- Involvement of signaling through protein kinase C and Phosphatidylinositol 3–kinase in the excystation and metacystic development of Entamoeba invadens
- … of glial cell‐derived neurotrophic factor and cardiotrophin‐1 protects PC12 cells from injury: Involvement of the Phosphatidylinositol 3‐kinase and mitogen‐activated …
- α4 integrin signaling activates Phosphatidylinositol 3–kinase and stimulates T cell adhesion to intercellular adhesion molecule-1 to a similar extent as CD3, but …
- Prolongation of insulin-induced activation of mitogen-activated protein kinases ERK 1/2 and Phosphatidylinositol 3–kinase by vanadyl sulfate, a protein tyrosine …
- Cbl PYXXM motifs activate the P85 subunit of Phosphatidylinositol 3–kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in …
- An E2F-binding site mediates the activation of the proliferative isoform of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase by Phosphatidylinositol 3–kinase
- Association between the Met326Ile Polymorphism of the p85α Regulatory Subunit of Phosphatidylinositol 3–kinase and Prostate Cancer Risk: A Prospective Study
- … coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-γ1 activation downstream of Phosphatidylinositol 3–kinase
- Exposure to asphalt fumes activates activator protein-1 through the Phosphatidylinositol 3–kinase/Akt signaling pathway in mouse epidermal cells
- … Ethanol on the Rat Glutamate Excitatory Amino Acid Transporter Type 3 Expressed in Xenopus Oocytes: Role of Protein kinase C and Phosphatidylinositol 3‐kinase
- Functional role of Phosphatidylinositol 3–kinase in direct tumor lysis by human natural killer cells
- Involvement of type I protein kinase A in the differentiation of L6 myoblast in conjunction with Phosphatidylinositol 3–kinase.
- … cell cycle progression through the synthesis of c-Myc protein by internal ribosome entry site–mediated translation via Phosphatidylinositol 3–kinase pathway in human …
- Src tyrosine kinase-induced loss of luteinizing hormone responsiveness is via a Ras-dependent, Phosphatidylinositol–3–kinase independent pathway
- A positive role of Phosphatidylinositol 3–kinase in aging phenotype expression in cultured human diploid fibroblasts
- Interleukin-2 receptors and interleukin-2-mediated signaling in myelin: activation of diacylglycerol kinase and Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase Inhibitor Failed to Reduce Cerebral Vasospasm in Dog Model of Experimental Subarachnoid Hemorrhage
- Roles of tyrosine kinase–, 1-Phosphatidylinositol 3–kinase–, and mitogen-activated protein kinase–signaling pathways in ethanol-induced contractions of rat aortic …
- Activation and Phosphatidylinositol 3–kinase-dependent phosphorylation of protein kinase C-epsilon by the B cell antigen receptor
- Two modes of secretion in pancreatic acinar cells: involvement of Phosphatidylinositol 3–kinase and regulation by capacitative Ca2+ entry
- Lipidomic processes in homeostatic and LPS-modified cell renewal cycle. Role of Phosphatidylinositol 3–kinase pathway in biomembrane synthesis and restitution of …
- … pylori Lipopolysaccharide Interference with Gastric Mucin Synthesis by Peroxisome Proliferator‐Activated Receptor γ Activation Involves Phosphatidylinositol 3‐kinase …
- Defective Activation of Atypical Protein kinase C ζ and λ by Insulin and Phosphatidylinositol–3,4,5-(PO4)3 in Skeletal Muscle of Rats Following High-Fat Feeding and …
- Rosiglitazone reverses insulin secretion altered by chronic exposure to free fatty acid via IRS-2-associated Phosphatidylinositol 3–kinase pathway.
- α2 Adrenoceptor‐mediated vasoconstriction in porcine palmar lateral vein: role of Phosphatidylinositol 3‐kinase and EGF receptor transactivation
- … factor-beta mediated contraction of human dermal fibroblast populated lattices is inhibited by Rho/GTPase inhibitor but does not require Phosphatidylinositol–3‘kinase.
- ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/Phosphatidylinositol 3–kinase signaling
- Phosphatidylinositol‐3 kinase p85 enhances expression from the myelin basic protein promoter in oligodendrocytes
- Differential ligand recognition by the Src and Phosphatidylinositol 3–kinase Src homology 3 domains: circular dichroism and ultraviolet resonance Raman studies
- The role of Phosphatidylinositol 3–kinase (PI3K) in CO2 stimulation of the Na+/HCO3-cotransporter (NBC)
- Growth-inhibitory effect of Phosphatidylinositol 3–kinase inhibitor on human pancreatic cancer cells and expression of Bcl-2 family.
- Growth and Molecular Profile of Lung Cancer Cells Expressing Ectopic LKB1 Down-Regulation of the Phosphatidylinositol 3′-Phosphate kinase/PTEN Pathway
- ARNO but not cytohesin‐1 translocation is Phosphatidylinositol 3‐kinase‐dependent in HL‐60 cells
- Stimulated tyrosine phosphorylation of Phosphatidylinositol 3–kinase causes acidic pH-induced contraction in spontaneously hypertensive rat aorta
- Signal transducer and activator of transcription-3 and Phosphatidylinositol–3 kinase as coordinate regulators of melanoma cell response to glucocorticoid hormones
- Phosphatidylinositol–3 kinase-dependent activation of Akt does not correlate with either high mitogenicity or cell migration induced by FGF-1.
- The Phosphatidylinositol–3 kinase pathway is not essential for insulin-like growth factor I receptor-mediated clonogenic radioresistance
- PDGF stimulates DNA synthesis in human vascular smooth muscle cells via a novel wortmannin-insensitive Phosphatidylinositol 3–kinase
- Promoter polymorphisms− 359T/C and− 303A/G of the catalytic subunit p110β gene of human Phosphatidylinositol 3–kinase are not associated with insulin secretion …
- Co-operation of Phosphatidylinositol transfer protein with phosphoinositide 3–kinase g in vitro
- Activation of Phosphatidylinositol 3–kinase in human breast carcinoma
- Cell adhesion induces the plasminogen activator inhibitor-1 gene expression through Phosphatidylinositol 3–kinase/Akt activation in anchorage dependent cells
- Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras–Phosphatidylinositol–3–kinase pathway
- In the article “Phosphatidylinositol 3–kinase Is Required for the Expression But Not for the Induction or the Maintenance of Long-Term Potentiation in the Hippocampal …
- … cultured with a fusion protein of insulin‐like growth factor II (IGF‐II) and interleukin 3 (IL‐3) is associated with increases in Bcl‐xL and Phosphatidylinositol‐3 kinase …
- Search for a molecular determinant in Phosphatidylinositol–3–kinase molecules, involved in the interaction with the beta-gamma-G protein dimer
- Expression of an active p110 catalytic subunit of Phosphatidylinositol 3‐kinase alters the proliferative capacity of interleukin‐2 receptor signals
- CD40 induces human multiple myeloma cell migration via Phosphatidylinositol 3–kinase/AKT/NF-B signaling
- Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system: Interaction of estrogen receptor α with Phosphatidylinositol 3-OH …
- Role of the Phosphatidylinositol 3 kinase-Akt
- TNF-alpha induced chondrocyte apoptosis in NF-κB suppression is augmented by inhibition of p38 mitogen-activated protein kinase or Phosphatidylinositol 3–kinase
- Defective Hyphal Induction of a Candida albicans Phosphatidylinositol 3-Phosphate 5-kinase Null Mutant on Solid Media Does Not Lead to Decreased Virulence
- The biological effect of the Phosphatidylinositol 3–kinase wortmannin following thermal neutron irradiation
- Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on Phosphatidylinositol 3-and Src-kinase activation and …
- A Role for the Phosphatidylinositol–3–kinase Pathway in Preconditioning
- Roles of Phosphatidylinositol 3–kinase (PI3K) and Rac1
- Roles of Phosphatidylinositol 3–kinase (PI3K) and Rac 1
- Gene expression profile analysis of the Phosphatidylinositol 3–kinase pathway in the developing small intestine
- Defining the physiological role of Phosphatidylinositol 3–kinase protein kinase activity
- Characterisation of aggresome formation by the class III Phosphatidylinositol 3–kinase and its adaptor protein, p150.
- Class IA Phosphatidylinositol 3–kinase involvement in cytoskeletal regulation
- Novel age-associated induction of components of the Phosphatidylinositol–3 kinase (PI3K)/Akt signaling in the intestine
- TEL/platelet-derived growth factor receptor β activates Phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle
- Negative regulation of transforming growth factorbeta/SMAD by Phosphatidylinositol 3–kinase pathway in neuroblastomas
- Investigating the effect of altered nutrition on signalling via Drosophila class 1A Phosphatidylinositol–3 kinase (PI3K), and functional analysis of PI3K mutated …
- Connective tissue growth factor inhibits apoptosis of human hypertrophic scar fibroblasts through Phosphatidylinositol 3–kinase/protein kinase B signal pathway
- Regulation of androgen receptor activity and degradation by the Phosphatidylinositol–3–kinase/Akt pathway, PTEN tumor suppressor, and Mdm2
- Epidermal growth factor-induced DNA synthesis: key roles for Phosphatidylinositol 3–kinase and the adaptor protein Gab2
- Requirement of BMP-2-induced Phosphatidylinositol 3–kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene …
- In vivo administration of glucosamine inhibited Phosphatidylinositol 3–kinase activity without affecting tyrosine phosphorylation of the insulin receptor or insulin …
- Functional Cooperation among Ras, STAT5, and Phosphatidylinositol 3–kinase Is Required for Full Oncogenic Activities of BCR/ABL in K562 Cells
- Apoptosis of differentiated HL-60 cells induced by inhibitor of Phosphatidylinositol 3–kinase
- 1141. Insulin-Like Growth Factor-1 Enhances Plasmid Transgene Expression through a Phosphatidylinositol 3–kinase-Dependent Pathway
- Phosphatidylinositol (3, 4, 5) P3 is essential but not sufficient for protein kinase B (PKB) activation; Phosphatidylinositol (3, 4) P2 is required for PKB …
- DEFECTS IN INTERMEDIATE INSULIN SIGNALING IN SKELETAL MUSCLE: Phosphatidylinositol (PI) 3–kinase AND GLUCOSE TRANSPORT
- … CANCER: ANTIMONY VERSUS TECHNETIUM-99 FILTERED SULFUR COLLOID52. THE INVOLVEMENT OF Phosphatidylinositol 3–kinase (PI3-K)/AKT …
- Insulin activates CCAAT/enhancer binding proteins and proinflammatory gene expression through the Phosphatidylinositol 3–kinase pathway in vascular smooth …
- Phosphatidylinositol kinase enzymes regulate the retrograde axonal transport of NT‐3 and NT‐4 in sympathetic and sensory neurons
- The Role of Phosphatidylinositol 3‘-OH kinase Signaling in Mammary Tumorigenesis
- Epithelial–mesenchymal transition in development and cancer: role of Phosphatidylinositol 3′ kinase/AKT pathways
- The pivotal role of Phosphatidylinositol 3–kinase–Akt signal transduction in virus survival
- Phosphatidylinositol 3–kinase mutations identified in human cancer are oncogenic
- Targeting the Phosphatidylinositol–3 kinase/Akt pathway for the treatment of cancer.
- Inhibition of Rho-kinase leads to rapid activation of Phosphatidylinositol 3–kinase/protein kinase Akt and cardiovascular protection
- The prognostic significance of Phosphatidylinositol 3–kinase pathway activation in human gliomas
- Exercise activates the Phosphatidylinositol 3–kinase pathway
- Early involvement of the Phosphatidylinositol 3–kinase/Akt pathway in lung cancer progression
- Postconditioning: a form of “modified reperfusion” protects the myocardium by activating the Phosphatidylinositol 3–kinase-Akt pathway
- Cell type-specific expression of the IκB kinases determines the significance of Phosphatidylinositol 3–kinase/Akt signaling to NF-κB activation
- Type I transforming growth factor β receptor binds to and activates Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase–Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling
- Regulation of Cu/Zn-superoxide dismutase expression via the Phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-κB
- The Phosphatidylinositol‐3 kinase pathway regulates bladder cancer cell invasion
- Novel role for Na, K-ATPase in Phosphatidylinositol 3–kinase signaling and suppression of cell motility
- Inhibition of Phosphatidylinositol 3–kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.
- … growth factor transcriptional activation is mediated by hypoxia-inducible factor 1α, HDM2, and p70S6K1 in response to Phosphatidylinositol 3–kinase/AKT …
- … metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and Phosphatidylinositol 3–kinase/Akt signaling pathways
- Focal adhesion kinase is upstream of Phosphatidylinositol 3–kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices …
- Pancreatic stellate cell migration: role of the Phosphatidylinositol 3–kinase (PI3–kinase) pathway
- Inhibition of the Phosphatidylinositol 3–kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects
- Tobacco Carcinogen-Induced Cellular Transformation Increases Activation of the Phosphatidylinositol 3′-kinase/Akt Pathway in Vitro and in Vivo
- Phosphatidylinositol–3–kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury
- Activation of the Phosphatidylinositol 3–kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas …
- Cutting edge: T cell development requires the combined activities of the p110γ and p110δ catalytic isoforms of Phosphatidylinositol 3–kinase
- Auxin-induced reactive oxygen species production requires the activation of Phosphatidylinositol 3–kinase
- Involvement of the Phosphatidylinositol 3–kinase/rac1 and cdc42 pathways in radial migration of cortical neurons
- Nongenomic androgen activation of Phosphatidylinositol 3‐kinase/Akt signaling pathway in MC3T3‐E1 osteoblasts
- Flavivirus activates Phosphatidylinositol 3–kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection
- Activation of the pro-survival Phosphatidylinositol 3–kinase/AKT pathway by transforming growth factor-β1 in mesenchymal cells is mediated by p38 MAPK …
- Phosphatidylinositol 3–kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization
- Interleukin-18 is a pro-hypertrophic cytokine that acts through a Phosphatidylinositol 3–kinase-phosphoinositide-dependent kinase-1-Akt-GATA4 signaling …
- The p85α subunit of Phosphatidylinositol 3′-kinase binds to and stimulates the GTPase activity of Rab proteins
- Knockdown of MTP18, a novel Phosphatidylinositol 3–kinase-dependent protein, affects mitochondrial morphology and induces apoptosis
- Cross-Talk between Phosphatidylinositol 3–kinase/AKT and c-Jun NH2-Terminal kinase Mediates Survival of Isolated Human Islets
- Endoplasmic reticulum stress–induced apoptosis is partly mediated by reduced insulin signaling through Phosphatidylinositol 3–kinase/Akt and increased glycogen …
- Bisphenol a accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the Phosphatidylinositol 3–kinase pathway
- Lithium activates the Wnt and Phosphatidylinositol 3–kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors
- Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by Phosphatidylinositol 3–kinase/protein kinase B inhibitors
- Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the Phosphatidylinositol 3–kinase/Akt-dependent pathway
- Activation of Phosphatidylinositol 3–kinase by cellular prion protein and its role in cell survival
- BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-Phosphatidylinositol 3–kinase-dependent pathway during neuronal …
- Inhibition of Phosphatidylinositol 3′-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells
- The Phosphatidylinositol 3–kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-β1
- Phosphatidylinositol 3′-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells
- Latent membrane protein 2A inhibits transforming growth factor-β1-induced apoptosis through the Phosphatidylinositol 3–kinase/Akt pathway
- Microglia release activators of neuronal proliferation mediated by activation of mitogen‐activated protein kinase, Phosphatidylinositol‐3‐kinase/Akt and delta–Notch …
- Acanthamoeba castellanii Induces Host Cell Death via a Phosphatidylinositol 3–kinase-Dependent Mechanism
- Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by Phosphatidylinositol 3 kinase
- Both mitogen-activated protein kinase and Phosphatidylinositol 3–kinase signalling are required in epidermal growth factor-induced human trophoblast migration
- … protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase …
- Ceramide-1-phosphate promotes cell survival through activation of the Phosphatidylinositol 3–kinase/protein kinase B pathway
- … inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting Phosphatidylinositol 3′-kinase …
- Gi-protein-dependent inhibition of IL-12 production is mediated by activation of the Phosphatidylinositol 3–kinase-protein 3 kinase B/Akt pathway and JNK
- … through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the Phosphatidylinositol 3–kinase/Akt-dependent pathway
- Emodin inhibits tumor cell migration through suppression of the Phosphatidylinositol 3–kinase-Cdc42/Rac1 pathway
- Inhibition of Phosphatidylinositol 3–kinase sensitizes ovarian cancer cells to carboplatin and allows adjunct chemotherapy treatment
- … Induces Rapid Activation of Akt/Protein kinase B-Mammalian Target of Rapamycin-p70S6K Cascade through Phosphatidylinositol 3–kinase in Human Fibroblasts
- REDD1 integrates hypoxia-mediated survival signaling downstream of Phosphatidylinositol 3–kinase
- Mechanisms of erythropoietin‐mediated cardioprotection during ischemia‐reperfusion injury: role of protein kinase C and Phosphatidylinositol 3‐kinase signaling
- Sequential Activation of Phosphatidylinositol 3–kinase, βPix, Rac1, and Nox1 in Growth Factor-Induced Production of H2O2
- Production of matrix metalloproteinase‐9 by activated human monocytes involves a Phosphatidylinositol‐3 kinase/Akt/IKKα/NF‐κB pathway
- Isoflurane protects against myocardial infarction during early reperfusion by activation of Phosphatidylinositol–3–kinase signal transduction: evidence for anesthetic …
- … progenitors and differentiated osteoblasts by β-catenin-dependent and-independent signaling cascades involving Src/ERK and Phosphatidylinositol 3–kinase …
- Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the Phosphatidylinositol 3–kinase/mTOR pathway
- Human placental growth hormone increases expression of the p85 regulatory unit of Phosphatidylinositol 3–kinase and triggers severe insulin resistance in skeletal …
- Induction of androgen receptor expression by Phosphatidylinositol 3–kinase/Akt downstream substrate, FOXO3a, and their roles in apoptosis of LNCaP …
- Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and Phosphatidylinositol 3–kinase/Akt signaling
- WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of Phosphatidylinositol 3–kinase
- Role of Phosphatidylinositol 3–kinase in the development of hepatocyte preconditioning
- Overexpression of NBS1 contributes to transformation through the activation of Phosphatidylinositol 3–kinase/Akt
- TGF-β1 represses activation and resultant death of microglia via inhibition of Phosphatidylinositol 3–kinase activity
- Inhibition of Phosphatidylinositol 3–kinase amplifies TEGDMA-induced apoptosis in primary human pulp cells
- Mutant epidermal growth factor receptor displays increased signaling through the Phosphatidylinositol–3 kinase/AKT pathway and promotes radioresistance in cells of …
- Atypical protein kinase C (PKCζ/λ) is a convergent downstream target of the insulin-stimulated Phosphatidylinositol 3–kinase and TC10 signaling pathways
- Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of Phosphatidylinositol 3–kinase and Syk-mediated pathways
- Modulation of Phosphatidylinositol‐3‐kinase/protein kinase B‐and mitogen‐activated protein kinase‐pathways by tea polyphenols in human prostate cancer cells
- Inhibition of Phosphatidylinositol–3–kinase causes increased sensitivity to radiation through a PKB-dependent mechanism
- Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the Phosphatidylinositol 3–kinase/AKT-signaling pathway
- Akt2, a novel functional link between p38 mitogen-activated protein kinase and Phosphatidylinositol 3–kinase pathways in myogenesis
- Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase-and Phosphatidylinositol 3–kinase-dependent signaling pathways
- Regulation of heme oxygenase-1 expression through the Phosphatidylinositol 3–kinase/Akt pathway and the Nrf2 transcription factor in response to the …
- Mammalian target of rapamycin positively regulates collagen type I production via a Phosphatidylinositol 3–kinase-independent pathway
- Alteration of Phosphatidylinositol 3–kinase cascade in the multilobulated nuclear formation of adult T cell leukemia/lymphoma (ATLL)
- Aging is associated with decreased pancreatic acinar cell regeneration and Phosphatidylinositol 3–kinase/Akt activation
- Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin (PI3K …
- PIKE (Phosphatidylinositol 3–kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion
- Se-methylselenocysteine inhibits Phosphatidylinositol 3–kinase activity of mouse mammary epithelial tumor cells in vitro
- CXCL16 signals via Gi, Phosphatidylinositol 3–kinase, Akt, IκB kinase, and nuclear factor-κB and induces cell-cell adhesion and aortic smooth muscle cell …
- Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-Phosphatidylinositol 3′-kinase signaling …
- WNK1 activates SGK1 by a Phosphatidylinositol 3–kinase-dependent and non-catalytic mechanism
- Phosphatidylinositol 3–kinase-Mediated Effects of Glucose on Vacuolar H+-ATPase Assembly, Translocation, and Acidification of Intracellular Compartments in Renal …
- The Phosphatidylinositol–3–kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non–small cell …
- … protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the Phosphatidylinositol 3–kinase/Akt antiapoptotic pathway
- Transforming growth factor-β activation of Phosphatidylinositol 3–kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated …
- Isoflurane-induced myocardial preconditioning is dependent on Phosphatidylinositol–3–kinase/Akt signalling
- PTEN, but not SHIP2, suppresses insulin signaling through the Phosphatidylinositol 3–kinase/Akt pathway in 3T3-L1 adipocytes
- Retroinfusion of embryonic endothelial progenitor cells attenuates ischemia-reperfusion injury in pigs: role of Phosphatidylinositol 3–kinase/AKT kinase
- … stress induces insulin resistance by activating the nuclear factor-κB pathway and disrupting normal subcellular distribution of Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase C2α is essential for ATP-dependent priming of neurosecretory granule exocytosis
- … -macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and Phosphatidylinositol 3–kinase/Akt
- Phosphatidylinositol 3–kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients
- Presenilins mediate Phosphatidylinositol 3–kinase/AKT and ERK activation via select signaling receptors: selectivity of PS2 in platelet-derived growth factor …
- Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by Phosphatidylinositol 3–kinase and cytohesin-1
- Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a Phosphatidylinositol 3–kinase/Akt and p38 kinase-dependent STAT3 …
- Phosphatidylinositol 3‐kinase and Akt effectors mediate insulin‐like growth factor‐I neuroprotection in dorsal root ganglia neurons
- Transformation potential of Ras isoforms correlates with activation of Phosphatidylinositol 3–kinase but not ERK
- Hypoxia-induced activation of p38 mitogen-activated protein kinase and Phosphatidylinositol 3′-kinase signaling pathways contributes to expression of interleukin 8 …
- Participation of prolactin receptors and Phosphatidylinositol 3–kinase and MAP kinase pathways in the increase in pancreatic islet mass and sensitivity to …
- … ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and Phosphatidylinositol 3–kinase/Akt
- A3 adenosine receptor activation inhibits cell proliferation via Phosphatidylinositol 3–kinase/Akt-dependent inhibition of the extracellular signal-regulated …
- … -I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signal-regulated protein kinase and Phosphatidylinositol 3–kinase …
- … affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through Phosphatidylinositol 3–kinase …
- Increased phosphorylation of AKAP by inhibition of Phosphatidylinositol 3–kinase enhances human sperm motility through tail recruitment of protein kinase A
- Vacuolar H+-ATPase binding to microfilaments: regulation in response to Phosphatidylinositol 3–kinase activity and detailed characterization of the actin …
- Inhibition of Phosphatidylinositol 3–kinase modifies boar sperm motion parameters
- Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the Phosphatidylinositol 3–kinase-Akt pathway
- Phosphatidylinositol 3–kinase inhibition down-regulates survivin and facilitates TRAIL-mediated apoptosis in neuroblastomas
- Phosphatidylinositol 3–kinase/Akt regulates angiotensin II–induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and …
- Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the Phosphatidylinositol 3–kinase pathway: role of upstream stimulatory factor
- Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the Phosphatidylinositol 3–kinase/Akt and Raf/ERK pathways transmit …
- … induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the Phosphatidylinositol 3–kinase/PTEN/AKT/mammalian …
- Phosphatidylinositol 3–kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression
- Zn2+ inhibits mitochondrial movement in neurons by Phosphatidylinositol 3–kinase activation
- … activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/Phosphatidylinositol 3–kinase …
- Activation of Phosphatidylinositol 3–kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and …
- Platelet-derived growth factor stimulates membrane lipid synthesis through activation of Phosphatidylinositol 3–kinase and sterol regulatory element-binding …
- Phosphatidylinositol 3–kinase is involved in α2 (I) collagen gene expression in normal and scleroderma fibroblasts
- IGF-I inhibits apoptosis through the activation of the Phosphatidylinositol 3–kinase/Akt pathway in pituitary cells
- Phosphatidylinositol 3–kinase Offsets cAMP-Mediated Positive Inotropic Effect via Inhibiting Ca2+ Influx in Cardiomyocytes
- Formation of E-cadherin-mediated cell-cell adhesion activates AKT and mitogen activated protein kinase via Phosphatidylinositol 3 kinase and ligand-independent …
- Lipoteichoic acid induces nuclear factor‐κB activation and nitric oxide synthase expression via Phosphatidylinositol 3‐kinase, Akt, and p38 MAPK in RAW 264.7 …
- Glucocorticoid receptor counteracts tumorigenic activity of Akt in skin through interference with the Phosphatidylinositol 3–kinase signaling pathway
- Phosphatidylinositol–3 kinase/Akt and GSK-3 mediated cytoprotective effect of epigallocatechin gallate on oxidative stress-injured neuronal-differentiated N18D3 cells
- Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of Phosphatidylinositol 3–kinase/AKT/GSK-3β …
- … -dependent insulinotropic polypeptide (GIP) stimulation of pancreatic β-cell survival is dependent upon Phosphatidylinositol 3–kinase (PI3K)/protein kinase B …
- Role of the Phosphatidylinositol 3′-kinase–Akt signal pathway in the proliferation of human pancreatic ductal carcinoma cell lines
- Signal regulatory protein α ligation induces macrophage nitric oxide production through JAK/STAT-and Phosphatidylinositol 3–kinase/Rac1/NAPDH oxidase/H2O2 …
- Stable activation of Phosphatidylinositol 3–kinase in the T cell immunological synapse stimulates Akt signaling to FoxO1 nuclear exclusion and cell growth control
- Activation of the Phosphatidylinositol 3–kinase/Akt pathway prevents radiation-induced apoptosis in breast cancer cells
- Hyaluronic acid induces osteopontin via the Phosphatidylinositol 3–kinase/Akt pathway to enhance the motility of human glioma cells
- … regulated by coexpression of human epidermal growth factor receptor 2 and epidermal growth factor receptor via Phosphatidylinositol 3–kinase/AKT signaling pathway …
- CD28 regulates the translation of Bcl-xL via the Phosphatidylinositol 3–kinase/mammalian target of rapamycin pathway
- Impaired activation of Phosphatidylinositol 3–kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity
- Regulation of cholinergic gene expression by nerve growth factor depends on the Phosphatidylinositol‐3′‐kinase pathway
- Inhibition of Phosphatidylinositol 3′-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway
- Nickel Compounds Act through Phosphatidylinositol–3–kinase/Akt-Dependent, p70S6k-Independent Pathway to Induce Hypoxia Inducible Factor Transactivation and …
- Enteric neuroblasts require the Phosphatidylinositol 3–kinase/Akt/Forkhead pathway for GDNF-stimulated survival
- Differential activation of the Phosphatidylinositol 3′-kinase/Akt survival pathway by ionizing radiation in tumor and primary endothelial cells
- Activation of Rac1 by Phosphatidylinositol 3‐kinase in vivo: role in activation of mitogen‐activated protein kinase (MAPK) pathways and retinoic acid‐induced …
- Induction of KLF2 by fluid shear stress requires a novel promoter element activated by a Phosphatidylinositol 3–kinase-dependent chromatin-remodeling …
- Insulin generates free radicals by an NAD (P) H, Phosphatidylinositol 3′-kinase-dependent mechanism in human skin fibroblasts ex vivo
- Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a Phosphatidylinositol 3–kinase/ERK-dependent and Akt …
- Phosphatidylinositol 3–kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42
- … /human herpesvirus 8 envelope glycoprotein gB induces the integrin-dependent focal adhesion kinase-Src-Phosphatidylinositol 3–kinase-rho GTPase signal pathways …
- Nerve growth factor promotes the survival of sympathetic neurons through the cooperative function of the protein kinase C and Phosphatidylinositol 3–kinase …
- Roles of the Ras-MEK-mitogen-activated protein kinase and Phosphatidylinositol 3–kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation …
- Inhibition of p38 mitogen-activated protein kinase and Phosphatidylinositol 3–kinase decreases UVB-induced activator protein-1 and cyclooxygenase-2 in a SKH-1 …
- … induces proliferation, migration, and TGF-β1 expression in mouse glomerular endothelial cells via mitogen-activated protein kinase and Phosphatidylinositol 3–kinase
- p38 and EGF receptor kinase-mediated activation of the Phosphatidylinositol 3–kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression
- Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the Phosphatidylinositol 3–kinase/AKT/Ras homolog enriched in brain (Rheb) …
- … line-derived neurotrophic factor increases intracellular calcium concentration: role of calcium/calmodulin in the activation of the Phosphatidylinositol 3–kinase …
- Reciprocal control of Forkhead box O 3a and c-Myc via the Phosphatidylinositol 3–kinase pathway coordinately regulates p27Kip1 levels
- Facilitation of conditioned fear extinction by d-cycloserine is mediated by mitogen-activated protein kinase and Phosphatidylinositol 3–kinase cascades and requires …
- … box transcription factor FOXO3a regulates estrogen receptor alpha expression and is repressed by the Her-2/neu/Phosphatidylinositol 3–kinase/Akt signaling pathway
- Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via Phosphatidylinositol 3–kinase/Akt/nuclear factor-κB cascade …
- … is enhanced by N-methyl-D-aspartate receptor activation: essential role of a TNF receptor 2-mediated Phosphatidylinositol 3–kinase-dependent NF-κB …
- LY294002 inhibits LPS-induced NO production through a inhibition of NF-κB activation: independent mechanism of Phosphatidylinositol 3–kinase
- Resistin promotes smooth muscle cell proliferation through activation of extracellular signal–regulated kinase 1/2 and Phosphatidylinositol 3–kinase pathways
- A late, prolonged activation of the Phosphatidylinositol 3–kinase pathway is required for T cell proliferation
- Morphine enhances isoflurane-induced postconditioning against myocardial infarction: the role of Phosphatidylinositol–3–kinase and opioid receptors in rabbits
- Calcium-induced Human Keratinocyte Differentiation Requires src- and fyn-mediated Phosphatidylinositol 3–kinase–dependent Activation of Phospholipase C-γ1
- FGF-2 induced by interleukin-1β through the action of Phosphatidylinositol 3–kinase mediates endothelial mesenchymal transformation in corneal endothelial …
- … of peroxisome proliferator-activated receptor-γ by insulin and C-peptide in kidney proximal tubular cells: dependent on Phosphatidylinositol 3–kinase activity
- IL-18 induces monocyte chemotactic protein-1 production in macrophages through the Phosphatidylinositol 3–kinase/Akt and MEK/ERK1/2 pathways
- Erythropoietin just before reperfusion reduces both lethal arrhythmias and infarct size via the Phosphatidylinositol–3 kinase-dependent pathway in canine hearts
- FSH activates Phosphatidylinositol 3–kinase/protein kinase B signaling pathway in 20-day-old Sertoli cells independently of IGF-I
- Dexamethasone suppresses antigen-induced activation of Phosphatidylinositol 3–kinase and downstream responses in mast cells
- Inhibition of the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung …
- Apoptosis and inhibition of the Phosphatidylinositol 3–kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone
- Identification of transcription factor binding sites upstream of human genes regulated by the Phosphatidylinositol 3–kinase and MEK/ERK signaling pathways
- Up-regulation of endothelial nitric oxide synthase via Phosphatidylinositol 3–kinase pathway contributes to ischemic tolerance in the CA1 subfield of gerbil …
- TRAIL-induced apoptosis in human vascular endothelium is regulated by Phosphatidylinositol 3–kinase/Akt through the short form of cellular FLIP and Bcl-2
- Topical treatment with inhibitors of the Phosphatidylinositol 3′-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase …
- Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and Phosphatidylinositol 3–kinase signaling
- A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by Phosphatidylinositol–3 kinase/Akt in HER2 overexpressing cells
- IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through Phosphatidylinositol 3′-kinase/Akt, heat shock protein …
- FasL (CD95L/APO-1L) resistance of neurons mediated by Phosphatidylinositol 3–kinase-Akt/protein kinase B-dependent expression of lifeguard/neuronal membrane …
- A role for Phosphatidylinositol 3–kinase in TCR-stimulated ERK activation leading to paxillin phosphorylation and CTL degranulation
- Systematic evaluation of anti-apoptotic growth factor signaling in vascular smooth muscle cells: only Phosphatidylinositol 3′-kinase is important
- Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by Phosphatidylinositol 3–kinase/AKT signaling
- Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated Phosphatidylinositol 3–kinase/Akt/GSK-3β signaling and leads to an …
- Trophic signals acting via Phosphatidylinositol–3 kinase are required for normal pre-implantation mouse embryo development
- Human mesothelioma cells exhibit tumor cell–specific differences in Phosphatidylinositol 3–kinase/AKT activity that predict the efficacy of Onconase
- … lipoprotein inhibits thrombin-induced endothelial tissue factor expression through inhibition of RhoA and stimulation of Phosphatidylinositol 3–kinase but not Akt …
- Inhibition of Phosphatidylinositol 3–kinase-and ERK MAPK-regulated protein synthesis reveals the pro-apoptotic properties of CD40 ligation in carcinoma cells
- HIV‐1 gp120‐induced TNF‐α production by primary human macrophages is mediated by Phosphatidylinositol‐3 (PI‐3) kinase and mitogen‐activated protein (MAP) …
- … proliferator-activated receptor-γ by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a Phosphatidylinositol 3′-kinase …
- A linear signal transduction pathway involving Phosphatidylinositol 3–kinase, protein kinase Cϵ, and MAPK in mesangial cells regulates interferon-γ-induced …
- Inhibition of Phosphatidylinositol 3–kinase/Akt and histone deacetylase activity induces apoptosis in non–small cell lung cancer in vitro and in vivo
- Interaction and functional analyses of human VPS34/p150 Phosphatidylinositol 3‐kinase complex with Rab7
- The pro-inflammatory mediator leukotriene D4 induces Phosphatidylinositol 3–kinase and Rac-dependent migration of intestinal epithelial cells
- … -Induced Oocyte Maturation in Atlantic Croaker (Micropogonias undulatus) Is Dependent on Activation of the Phosphatidylinositol 3–kinase/Akt Signal Transduction …
- Inhibition of the Phosphatidylinositol 3′-kinase signaling pathway leads to decreased insulin-stimulated adiponectin secretion from 3T3-L1 adipocytes
- Treating breast cancer through novel inhibitors of the Phosphatidylinositol 3‘-kinase pathway
- Phosphatidylinositol 3‐kinase and Akt participate in the FSH‐induced meiotic maturation of mouse oocytes
- Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits Phosphatidylinositol 3–kinase through binding to PIKE-L
- Activation of Phosphatidylinositol 3–kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast …
- The magnitude of Akt/Phosphatidylinositol 3′-kinase proliferating signaling is related to CD45 expression in human myeloma cells
- Response of Non–Small Cell Lung Cancer Cells to the Inhibitors of Phosphatidylinositol 3–kinase/Akt- and MAPK kinase 4/c-Jun NH2-Terminal kinase Pathways …
- RhoA activation mediates Phosphatidylinositol 3–kinase–dependent proliferation of human vascular endothelial cells: an alloimmune mechanism of chronic allograft …
- Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the Phosphatidylinositol 3–kinase/protein kinase A/c-Raf …
- … substrate metabolism of mouse cumulus-oocyte complexes: response to follicle-stimulating hormone is mediated by the Phosphatidylinositol 3–kinase pathway and is …
- A Rac1/Phosphatidylinositol 3–kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide …
- Protein phosphatase-2Cα as a positive regulator of insulin sensitivity through direct activation of Phosphatidylinositol 3–kinase in 3T3-L1 adipocytes
- Suppression of Phosphatidylinositol 3–kinase/Akt signaling pathway is a determinant of the sensitivity to a novel histone deacetylase inhibitor, FK228, in lung …
- Phosphatidylinositol 3–kinase signaling is involved in neurogenesis during Xenopus embryonic development
- Phosphatidylinositol‐3 kinase is distinctively required for µ‐, but not κ‐opioid receptor‐induced activation of c‐Jun N‐terminal kinase
- AMPA protects cultured neurons against glutamate excitotoxicity through a Phosphatidylinositol 3‐kinase‐dependent activation in extracellular signal‐regulated …
- N-WASP and WAVE2 acting downstream of Phosphatidylinositol 3–kinase are required for myogenic cell migration induced by hepatocyte growth factor
- Differential sensitivity of Phosphatidylinositol 3–kinase p110γ to isoforms of G protein βγ dimers
- Epidermal growth factor stimulation of RPE cell survival: contribution of Phosphatidylinositol 3–kinase and mitogen-activated protein kinase pathways
- PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits Phosphatidylinositol 3–kinase signaling and suppresses growth of solid tumors
- Phosphatidylinositol 3–kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation
- Post-ischemic cardioprotection by A2A adenosine receptors: dependent of Phosphatidylinositol 3–kinase pathway
- Calorie restriction increases the ratio of Phosphatidylinositol 3–kinase catalytic to regulatory subunits in rat skeletal muscle
- nitric oxide triggers the Phosphatidylinositol 3–kinase/Akt survival pathway in insulin-producing RINm5F cells by arousing Src to activate insulin receptor substrate-1
- Phosphatidylinositol 3–kinase regulates thymic exit
- … Group A2 Potentiates Genotoxic Stress in Part through the Modulation of Basal and DNA Damage–Dependent Phosphatidylinositol 3–kinase–Related Protein kinase …
- Dynamic reorganization of the astrocyte actin cytoskeleton elicited by cAMP and PACAP: a role for Phosphatidylinositol 3‐kinase inhibition
- Pulmonary surfactant protein A activates a Phosphatidylinositol 3–kinase/calcium signal transduction pathway in human macrophages: participation in the up …
- Novel mechanism of interaction of p85 subunit of Phosphatidylinositol 3–kinase and ErbB3 receptor-derived phosphotyrosyl peptides
- Role for the pleckstrin homology domain-containing protein CKIP-1 in Phosphatidylinositol 3–kinase-regulated muscle differentiation
- VEGF165 and angiopoietin-1 decreased myocardium infarct size through Phosphatidylinositol–3 kinase and Bcl-2 pathways
- Hypothalamic Phosphatidylinositol 3‐kinase‐phosphodiesterase 3B‐cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion
- Akt2, Phosphatidylinositol 3–kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation
- CD40/CD40 homodimers are required for CD40-induced Phosphatidylinositol 3–kinase-dependent expression of B7. 2 by human B lymphocytes
- A permissive role for Phosphatidylinositol 3–kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor
- Epidermal growth factor–induced cyclooxygenase-2 expression is mediated through Phosphatidylinositol–3 kinase, not mitogen-activated protein/extracellular signal …
- The Phosphatidylinositol 3–kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) …
- Differential regulation of Phosphatidylinositol 3–kinase/Akt, mitogen-activated protein kinase, and AMP-activated protein kinase pathways during menadione-induced …
- Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via Phosphatidylinositol 3–kinase
- Costimulation by CD137/4–1BB inhibits T cell apoptosis and induces Bcl‐xL and c‐FLIPshort via Phosphatidylinositol 3‐kinase and AKT/protein kinase B
- A specific antagonist of the p110δ catalytic component of Phosphatidylinositol 3′-kinase, IC486068, enhances radiation-induced tumor vascular destruction
- The role of phospholipase C and Phosphatidylinositol 3–kinase in vascular smooth muscle cell migration and proliferation
- … hydroxy estradiol induces expression of hypoxia-inducible factor 1α and vascular endothelial growth factor A through Phosphatidylinositol 3–kinase/Akt/FRAP pathway …
- … class I antibodies confers resistance to endothelial cells against antibody complement‐mediated lysis by regulating Bad through the Phosphatidylinositol 3‐kinase/Akt …
- Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and Phosphatidylinositol 3–kinase but not extracellularly regulated …
- SH2-B promotes insulin receptor substrate 1 (IRS1)-and IRS2-mediated activation of the Phosphatidylinositol 3–kinase pathway in response to leptin
- The mammalian target of rapamycin-p70 ribosomal S6 kinase but not Phosphatidylinositol 3–kinase-Akt signaling is responsible for fibroblast growth factor-9 …
- … -induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and Phosphatidylinositol 3–kinase
- Low [Mg2+]e Enhances Arterial Spontaneous Tone via Phosphatidylinositol 3–kinase in DOCA-Salt Hypertension
- Inhibition of either Phosphatidylinositol 3–kinase/Akt or the mitogen/extracellular-regulated kinase, MEK/ERK, signaling pathways suppress growth of breast cancer …
- Phosphatidylinositol 3–kinase (PI-3K)/Akt but not PI-3K/p70 S6 kinase signaling mediates IGF-1-promoted lens epithelial cell survival
- … -δ12, 14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in Phosphatidylinositol 3–kinase-akt-NF-κB …
- The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via Phosphatidylinositol 3–kinase in glutamate-induced apoptosis of rat …
- Comparison of Phosphatidylinositol–3–kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA
- Gαq inhibits cardiac L-type Ca2+ channels through Phosphatidylinositol 3–kinase
- The influence of Phosphatidylinositol 3‐kinase/Akt pathway on the ischemic injury during rat liver graft preservation
- … ‐stimulating factor‐, or IL‐3‐dependent survival of macrophages, but not proliferation, requires the expression of p21Waf1 through the Phosphatidylinositol 3‐kinase …
- RhoA controls myoblast survival by inducing the Phosphatidylinositol 3‐kinase‐Akt signaling pathway
- Functional integrity of nuclear factor κB, Phosphatidylinositol 3′-kinase, and mitogen-activated protein kinase signaling allows tumor necrosis factor α-evoked Bcl-2 …
- Phosphatidylinositol 3–kinase, phosphoinositide-specific phospholipase-Cγ and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 …
- M-CSF stimulated differentiation requires persistent MEK activity and MAPK phosphorylation independent of Grb2–Sos association and Phosphatidylinositol 3–kinase …
- … Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-α production through inhibition of Phosphatidylinositol 3–kinase/Akt activation in …
- Activation of nuclear factor kappa B by diesel exhaust particles in mouse epidermal cells through Phosphatidylinositol 3–kinase/Akt signaling pathway
- Phosphatidylinositol 3–kinase is a determinant of responsiveness to B cell antigen receptor-mediated Epstein-Barr virus activation
- Phosphatidylinositol 3–kinase inhibitors reveal a unique mechanism of enhancing insulin secretion in 832/13 rat insulinoma cells
- The integrin β1 subunit transmembrane domain regulates Phosphatidylinositol 3–kinase-dependent tyrosine phosphorylation of Crk-associated substrate
- Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll‐like receptor 2, and Phosphatidylinositol‐3‐kinase
- cAMP-stimulated Na+ transport in H441 distal lung epithelial cells: role of PKA, Phosphatidylinositol 3–kinase, and sgk1
- Roles of Phosphatidylinositol 3′-kinase and mammalian target of rapamycin/p70 ribosomal protein S6 kinase in K-Ras-mediated transformation of intestinal epithelial …
- … regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the Phosphatidylinositol 3–kinase …
- … cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, Phosphatidylinositol 3–kinase, Akt, c-Jun …
- … Pathway Leads to Phosphorylation of Insulin Receptor Substrate-1 on Ser307 and Ser612 and Impairs the Phosphatidylinositol 3–kinase/Akt/Mammalian Target of …
- Phosphatidylinositol 3–kinase inhibitors are a triple threat to ovarian cancer
- Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related Phosphatidylinositol 3–kinase/Akt and p38 mitogen …
- Role of Phosphatidylinositol 3–kinase-γ in mediating lung neutrophil sequestration and vascular injury induced by E. coli sepsis
- Aquaporin-2 is retrieved to the apical storage compartment via early endosomes and Phosphatidylinositol 3–kinase-dependent pathway
- Regulation of granulocyte apoptosis by Phosphatidylinositol 3–kinase
- … in human breast cancer cells does not rely on direct induction of mitogen-activated protein kinase/extracellularly regulated kinase or Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers
- Control of cell size through phosphorylation of upstream binding factor 1 by nuclear Phosphatidylinositol 3–kinase
- Activation of Phosphatidylinositol 3‐kinase and c‐Jun‐N‐terminal kinase cascades enhances NF‐κB‐dependent gene transcription in BCG‐stimulated macrophages …
- Mouse embryonic stem cells and preimplantation embryos require signaling through the Phosphatidylinositol 3‐kinase pathway to suppress apoptosis
- Opposing roles of endothelial and smooth muscle Phosphatidylinositol 3–kinase in vasoconstriction: effects of rho-kinase and hypertension
- … -independent activation of GABAergic neurotransmission and receptor-dependent nontranscriptional activation of Phosphatidylinositol 3–kinase/protein kinase Akt …
- Muscarinic M2 receptor stimulation of Cav1. 2b requires Phosphatidylinositol 3–kinase, protein kinase C, and c-Src
- Vav-dependent and vav-independent Phosphatidylinositol 3–kinase activation in murine B cells determined by the nature of the stimulus
- … of the heavy chain of tetanus toxin rescues cerebellar granule neurones from apoptotic death: involvement of Phosphatidylinositol 3‐kinase and mitogen‐activated …
- Phosphatidylinositol 3–kinase/Akt pathway mediates heme oxygenase-1 regulation by lipopolysaccharide.
- Possible involvement of Phosphatidylinositol 3–kinase/Akt pathway in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblasts
- Deregulation of the Phosphatidylinositol–3 kinase signaling cascade is associated with neurodegeneration in Npc1−/− mouse brain
- Hydrogen peroxide and epidermal growth factor activate Phosphatidylinositol 3–kinase and increase sodium transport in A6 cell monolayers
- Involvement of Phosphatidylinositol 3–kinase and insulin-like growth factor-I in YXLST-mediated neuroprotection
- Survivin contributes to the anti-apoptotic activities of transforming growth factor alpha in mouse blastocysts through Phosphatidylinositol 3‘-kinase pathway
- … inhibits β-amyloid peptide (1-42)-mediated hippocampal neuronal apoptosis through activation of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3‐kinase inhibition enhances human sperm motility and sperm–zona pellucida binding
- Modulation of Phosphatidylinositol 3–kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts
- α1A-Adrenoceptors Activate Glucose Uptake in L6 Muscle Cells through a Phospholipase C-, Phosphatidylinositol–3 kinase-, and Atypical Protein kinase C …
- Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and Phosphatidylinositol 3‐kinase signalling and cell proliferation in serum‐deprived …
- … via modulation of involucrin and transglutaminase expression through the integrin α3β1 and the Phosphatidylinositol 3–kinase/Akt signaling pathway
- Phosphatidylinositol 3–kinase modulates vascular smooth muscle contraction by calcium and myosin light chain phosphorylation-independent and-dependent …
- … -1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the Phosphatidylinositol 3–kinase/protein kinase B …
- Mammalian target of rapamycin and 3–Phosphatidylinositol 3–kinase pathway inhibition enhances growth inhibition of transforming growth factor-β1 in prostate cancer …
- Fibroblast growth factor-2 induces osteoblast survival through a Phosphatidylinositol 3–kinase-dependent,-β-catenin-independent signaling pathway
- Activation of MMP-2 in response to vascular injury is mediated by Phosphatidylinositol 3–kinase-dependent expression of MT1-MMP
- Adhesion-independent α6β4 integrin clustering is mediated by Phosphatidylinositol 3–kinase
- … -induced integrin affinity maturation promotes recruitment of αVβ3 integrin to focal adhesions in endothelial cells: Evidence for a role of Phosphatidylinositol 3–kinase …
- NGF-induced Phosphatidylinositol 3–kinase signaling pathway prevents thapsigargin-triggered ER stress-mediated apoptosis in PC12 cells
- Optimal windows of statin use for immediate infarct limitation: 5′-nucleotidase as another downstream molecule of Phosphatidylinositol 3–kinase
- Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-Phosphatidylinositol 3–kinase signaling involves pleiotropic oncogenic …
- Phosphatidylinositol 3–kinase activator reduces motor neuronal cell death induced by G93A or A4V mutant SOD1 gene
- Transient Phosphatidylinositol 3–kinase inhibition protects immature primary cortical neurons from oxidative toxicity via suppression of extracellular signal …
- Exogenous tissue inhibitor of metalloproteinase‐1 promotes endothelial cell survival through activation of the Phosphatidylinositol 3‐kinase/Akt pathway
- Phosphatidylinositol 3–kinase activation is required for sulfonylurea stimulation of glucose transport in rat skeletal muscle
- Enhancement of osteopontin expression in HepG2 cells by epidermal growth factor via Phosphatidylinositol 3–kinase signaling pathway
- Cloning of Brassica napus phospholipase C2 (BnPLC2), Phosphatidylinositol 3–kinase (BnVPS34) and Phosphatidylinositol synthase1 (BnPtdIns S1)—comparative …
- Biochemical and biological responses induced by coupling of Gab1 to Phosphatidylinositol 3–kinase in RET-expressing cells
- … receptor β/δ (PPARβ/δ) increases the expression of prostaglandin E2 receptor subtype EP4: the roles of Phosphatidylinositol 3–kinase and CCAAT/enhancer …
- Phosphatidylinositol 3–kinase p85α subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological …
- α-Thrombin-mediated Phosphatidylinositol 3–kinase activation through release of Gβγ dimers from Gαq and Gαi2
- Angiotensin II Regulation of the Na+ Pump Involves the Phosphatidylinositol–3 kinase and p42/44 Mitogen-Activated Protein kinase Signaling Pathways in Vascular …
- Resensitization of P2Y Receptors by Growth Factor–Mediated Activation of the Phosphatidylinositol–3 kinase in Retinal Glial Cells
- Upregulated function of Phosphatidylinositol‐3‐kinase in genetically hypertensive rats: a moderator of arterial hypercontractility
- Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and Phosphatidylinositol–3 kinase in PC12 cells
- … , a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing Phosphatidylinositol 3–kinase activity in human …
- Leptin decreases renal medullary Na (+), K (+)-ATPase activity through Phosphatidylinositol 3–kinase dependent mechanism.
- Differential involvement of Phosphatidylinositol 3–kinase and p42/p44 mitogen activated protein kinase pathways in brain-derived neurotrophic factor-induced trophic …
- … epidermal growth factor‐like growth factor stimulates cell proliferation in cerebral cortical cultures through Phosphatidylinositol 3′‐kinase and mitogen‐activated …
- Two distinct regulatory mechanisms of neurotransmitter release by Phosphatidylinositol 3‐kinase
- AND-34 Activates Phosphatidylinositol 3–kinase and Induces Anti-Estrogen Resistance in a SH2 and GDP Exchange Factor–Like Domain-Dependent Manner
- Calcium oscillation and Phosphatidylinositol 3–kinase positively regulate integrin αIIbβ3-mediated outside-in signaling
- Overexpression of the N-terminal end of the p55γ regulatory subunit of Phosphatidylinositol 3–kinase blocks cell cycle progression in gastric carcinoma cells
- Inhibition of Phosphatidylinositol–3–kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria
- … neurones by brain‐derived neurotrophic factor and Raf‐1 protein kinase: role of extracellular signal‐regulated protein kinase and Phosphatidylinositol 3‐kinase
- Phosphatidylinositol–3–kinase activation mediates proline-rich tyrosine kinase 2 phosphorylation and recruitment to β1-integrins in human CD34+ cells
- Angiopoietin-1 attenuates H2O2-induced SEK1/JNK phosphorylation through the Phosphatidylinositol 3–kinase/Akt pathway in vascular endothelial cells
- RNA interference, A potential strategy for isoform-specific Phosphatidylinositol 3–kinase targeted therapy in ovarian cancer
- Expression of insulin receptor substrates 1-3, glucose transporters GLUT-1-4, signal regulatory protein 1α, Phosphatidylinositol 3–kinase and protein kinase B at the …
- Phosphatidylinositol 3–kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase
- In vitro metabolism of the Phosphatidylinositol 3–kinase inhibitor, wortmannin, by carbonyl reductase
- Interleukin-2-induced survival of natural killer (NK) cells involving Phosphatidylinositol–3 kinase-dependent reduction of ceramide through acid sphingomyelinase …
- T cell leukemia-1 modulates TCR signal strength and IFN-γ levels through Phosphatidylinositol 3–kinase and protein kinase C pathway activation
- Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via Phosphatidylinositol–3′-kinase
- Negative Feedback Regulation of Phosphatidylinositol 3‐kinase/Akt Pathway by Over‐Expressed Cyclooxygenase‐2 in Human Epidermal Cancer Cells
- Group IB secretory phospholipase A2 promotes matrix metalloproteinase-2-mediated cell migration via the Phosphatidylinositol 3–kinase and Akt pathway
- Phosphatidylinositol 3–kinase/Akt-dependent and-independent protection against apoptosis in normal human melanocytes
- Generation and functional in vivo characterization of a lipid kinase defective Phosphatidylinositol 3–kinase Vps34p of Candida albicans
- Phosphatidylinositol‐3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells
- … adhesion is controlled by src-kinases, whereas PF-4–mediated exocytosis requires the additional activation of p38 MAP kinase and Phosphatidylinositol 3–kinase
- Prolactin and heregulin override DNA damage-induced growth arrest and promote Phosphatidylinositol–3 kinase-dependent proliferation in breast cancer cells
- Hemangiopoietin inhibits apoptosis of MO7e leukemia cells through Phosphatidylinositol 3–kinase–AKT pathway
- Intrinsic regulation of the interactions between the SH3 domain of p85 subunit of Phosphatidylinositol–3 kinase and the protein network of BCR/ABL oncogenic …
- Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of Phosphatidylinositol 3–kinase and Rheb signaling
- Phosphatidylinositol 3–kinase regulates early differentiation in human laryngeal keratinocytes
- Raloxifene improves coronary perfusion, cardiac contractility, and myocardial metabolism in the ischemic heart: role of Phosphatidylinositol 3–kinase/Akt pathway
- Arrest of human lung fibroblasts in G2 phase after irradiation is regulated by converging Phosphatidylinositol–3 kinase and β1-integrin signaling in vitro
- … M stimulation of proliferation of prostate cancer 22Rv1 cells through the signaling pathways of p38 mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase
- … of the insulin-like growth factor-I receptor by angiotensin II mediates downstream signaling from the angiotensin II type 1 receptor to Phosphatidylinositol 3–kinase
- Skeletal muscle insulin signaling defects downstream of Phosphatidylinositol 3–kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in …
- … interleukin-1 receptor-associated kinase degradation in response to lipopolysaccharide: involvement of CD14/TLR4, CR3, and Phosphatidylinositol 3–kinase
- Constitutively activated Phosphatidylinositol 3–kinase primes platelets from patients with chronic myelogenous leukemia for thrombopoietin-induced aggregation
- Enhanced v-Src-induced oncogenic transformation in the absence of focal adhesion kinase is mediated by Phosphatidylinositol 3–kinase
- Phosphorylation of glycosyl-Phosphatidylinositol by Phosphatidylinositol 3–kinase changes its properties as a substrate for phospholipases
- Kainate mediates nuclear factor-kappa B activation in hippocampus via Phosphatidylinositol–3 kinase and extracellular signal-regulated protein kinase
- … apoptosis by GM‐CSF as a result of temporary suppression of FADD recruitment in neutrophils: evidence implicating Phosphatidylinositol 3‐kinase and MEK1‐ERK1 …
- Balamuthia mandrillaris stimulates interleukin-6 release in primary human brain microvascular endothelial cells via a Phosphatidylinositol 3–kinase-dependent …
- Suppression of a Phosphatidylinositol 3–kinase signal by a specific spliced variant of Drosophila PTEN
- Phosphatidylinositol 3–kinase-dependent mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 and NF-κB signaling pathways are required for B …
- … by granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor α: role of Phosphatidylinositol 3–kinase
- Direct activation of telomerase by GH via Phosphatidylinositol 3′-kinase
- The production of IL-1 receptor antagonist in IFN-β-stimulated human monocytes depends on the activation of Phosphatidylinositol 3–kinase but not of STAT1
- Defective Activation of Protein kinase Cz in Muscle by Insulin and Phosphatidylinositol–3,4,5,-(PO4)3 in Obesity and Polycystic Ovary Syndrome
- LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via Phosphatidylinositol 3–kinase-independent pathways to inhibit cell proliferation via mammalian …
- Carbamazepine enhances the activity of glutamate transporter type 3 via Phosphatidylinositol 3–kinase
- Inhibition of Phosphatidylinositol 3–kinase/Protein kinase B Signaling Is Not Sufficient to Account for Indole-3-Carbinol–Induced Apoptosis in Some Breast and …
- Phosphatidylinositol 3–kinase VPS34 of Candida albicans is involved in filamentous growth, secretion of aspartic proteases, and intracellular detoxification
- … epidermal growth factor-like growth factor inhibits cytokine-induced NF-κB activation and nitric oxide production via activation of the Phosphatidylinositol 3–kinase …
- … of ovarian insulin-like growth factor-binding protein-3 transcription requires a TATA box-binding protein and the protein kinase A and Phosphatidylinositol–3 kinase …
- CD4+ CD25+ regulatory T cells attenuate the Phosphatidylinositol 3–kinase/Akt pathway in antigen-primed immature CD8+ CTLs during functional maturation
- B cell receptor (BCR) cross-talk: IL-4 creates an alternate pathway for BCR-induced ERK activation that is Phosphatidylinositol 3–kinase independent
- Oxidized low‐density lipoprotein‐induced apoptosis is attenuated by insulin‐activated Phosphatidylinositol 3‐kinase/Akt through p38 mitogen‐activated protein kinase
- … signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased Phosphatidylinositol 3–kinase and AKT kinase …
- Growth factors change nuclear distribution of estrogen receptor-α via mitogen-activated protein kinase or Phosphatidylinositol 3–kinase cascade in a human breast …
- Protein kinase C modulates negatively the hepatocyte growth factor-induced migration, integrin expression and Phosphatidylinositol 3–kinase activation
- LY294002 inhibits monocyte chemoattractant protein-1 expression through a Phosphatidylinositol 3–kinase-independent mechanism
- Phosphatidylinositol–3–kinase regulates PKCθ activity in cytotoxic T cells
- Assay and Stimulation of the Rab5 GTPase by the p85α Subunit of Phosphatidylinositol 3‐kinase
- … -like growth factor (IGF) binding protein-3 synthesis by IGF-I and transforming growth factor-α is mediated by both Phosphatidylinositol–3 kinase and mitogen-activated …
- … phospholipase D pathway stimulated by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Involvement of EP2 receptors and Phosphatidylinositol 3–kinase …
- Integrated pharmacological preconditioning and memory of cardioprotection: role of protein kinase C and Phosphatidylinositol 3–kinase
- Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of Phosphatidylinositol 3–kinase and Crk, and activation of atypical protein kinase C and glucose …
- Hedamycin, a DNA alkylator, induces γH2AX and chromosome aberrations: Involvement of Phosphatidylinositol 3–kinase–related kinases and DNA replication fork …
- Insulin-like growth factor binding protein-3 stimulates Phosphatidylinositol 3–kinase in MCF-7 breast carcinoma cells
- Measurement of the Interaction of the p85α Subunit of Phosphatidylinositol 3‐kinase with Rab5
- Role of the Phosphatidylinositol 3–kinase and mitogen-activated protein kinase pathways in the secretion of tumor necrosis factor-α and interleukin-10 by the PPD …
- Possible involvement of Phosphatidylinositol 3–kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells
- Inhibition of Phosphatidylinositol–3–kinase causes cell death through a protein kinase B (PKB)-dependent mechanism and growth arrest through a PKB-independent …
- Leptin regulates insulin sensitivity via Phosphatidylinositol–3-OH kinase signaling in mediobasal hypothalamic neurons
- CD40-dependent activation of Phosphatidylinositol 3–kinase/AKT pathway inhibits apoptosis of human cultured mesangial cells induced by oxidized LDL
- Differential regulation of the regulatory subunits for Phosphatidylinositol 3–kinase in response to motor nerve injury
- Nerve growth factor restores p53 function in pituitary tumor cell lines via trkA-mediated activation of Phosphatidylinositol 3–kinase
- Ethanol impairs insulin’s actions through Phosphatidylinositol 3–kinase
- Alterations in lens protein tyrosine phosphorylation and Phosphatidylinositol 3–kinase signaling during selenite cataract formation
- Activation of Phosphatidylinositol 3–kinase-protein kinase B (PI3K-PKB) induced by 17beta-estradiol in endometrial carcinoma cell (Ishikawa)
- Phosphatidylinositol 3‐kinase is required for the transcriptional activation of cyclin D2 in BCR activated primary mouse B lymphocytes
- … factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via Phosphatidylinositol 3–kinase-dependent constitutive nitric …
- … blue 2 inhibition of cyclic AMP-dependent differentiation of rat C6 glioma cells by purinergic receptor-independent inactivation of Phosphatidylinositol 3–kinase
- … -like protein tyrosine phosphatase α, Src, and Rho to increase prolactin gene expression through a final Phosphatidylinositol 3–kinase/cytoskeletal pathway that is …
- Insulin-like growth factor I induces preferential degradation of insulin receptor substrate-2 through the Phosphatidylinositol 3–kinase pathway in human neuroblastoma …
- Inhibition of Phosphatidylinositol–3–kinase Enhances Insulin Stimulation of Insulin Receptor Substrate 1 Tyrosine Phosphorylation and Extracellular Signal-Regulated …
- Angiopoietin-1 reduces iopromide-induced endothelial cell apoptosis through activation of Phosphatidylinositol 3‘-kinase/p70 S6 kinase.
- Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent Phosphatidylinositol 3–kinase during insulin action in …
- The Phosphatidylinositol 3–kinase Vps34p of the human pathogenic yeast Candida albicans is a multifunctional protein that interacts with the putative vacuolar H+ …
- Phosphatidylinositol 3‐kinase and ERK1/2 are not involved in adenosine A1, A2A or A3 receptor‐mediated preconditioning in rat ventricle strips
- … activated receptor/(PPAR/) increases the expression of prostaglandin E2 receptor subtype EP4: the roles of Phosphatidylinositol 3–kinase and CCAAT/enhancer …
- Impaired Activation of Protein kinase C-ζ by Insulin and Phosphatidylinositol–3,4,5-(PO4)3 in Cultured Preadipocyte-Derived Adipocytes and Myotubes of Obese …
- A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a Phosphatidylinositol–3-OH-kinase-, cAMP-dependent …
- The role of Phosphatidylinositol–3 kinase in vanadate-promoted S phase entry
- Phosphatidylinositol 3–kinase, phosphoinositides and apoptosis
- ALCOHOLIC PANCREATIC FIBROSIS: ROLE OF THE Phosphatidylinositol–3 kinase (PI3-K) AND PROTEIN kinase C (PKC) PATHWAYS IN PANCREATIC …
- Role of Phosphatidylinositol–3 kinase in regulation of differential sensitivity of melanoma cells to antitumor agents. A model for hormone resistance development in …
- Differential Effects of Three Small Molecules Blocking Phosphatidylinositol–3 kinase or AKT in Hodgkin Disease Cell Lines: Induction of Apoptosis and Cell Cycle …
- Role of Phosphatidylinositol–3–kinase and protein kinase Cζ in the adenylate cyclase signal mechanism of action of relaxin in muscle tissues of rats and mollusks
- Novel expression patterns of Phosphatidylinositol 3‐hydroxy kinase in nodulated Medicago spp. plants
- Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the Phosphatidylinositol 3–kinase/Akt-dependent pathway
- Activation of the hexosamine pathway leads to phosphorylation of IRS-1 on Ser307 and Ser612 and impairs the Phosphatidylinositol 3–kinase/Akt/mTOR insulin …
- Enhancement of susceptibility to Fas-mediated apoptosis in HL-60 cells through down-regulation of cellular FLICE-inhibitory protein by Phosphatidylinositol 3–kinase …
- Role of extracellular signal‐regulated protein kinase and Phosphatidylinositol 3‐kinase in neuronal cell death and survival
- Inhibition of Phosphatidylinositol 3–kinase activity blocks nuclear accumulation of protein kinase zetta during granulocytic differentiation of HL-60 cells
- Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires Phosphatidylinositol 3-OH-kinase signaling
- Physiological role of Vps34 Phosphatidylinositol 3–kinase in mammalian cells
- Inhibition of Phosphatidylinositol 3–kinase causes apoptosis in retinoic acid-differentiated HL-60 leukemia cells
- Phosphatidylinositol 3–kinase (PI3K) cascade is a novel signaling pathway to mediate inflammatory pain
- Activation of the Phosphatidylinositol–3‘kinase pathway and DNA synthesis by a mutant insulin-like growth factor I receptor lacking the NPXY motif
- Estrogen receptor (ER) α and ERβ are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with Phosphatidylinositol–3-OH kinase/Akt …
- A novel Phosphatidylinositol 3–kinase inhibitor, ZSTK474 exerted antitumor activity against human tumor xenografts by oral administration
- Roles of Akt2 and the molecular balance of Phosphatidylinositol 3–kinase subunits in enhanced skeletal muscle insulin sensitivity with calorie restriction
- Activation of Phosphatidylinositol 3–kinase, Akt and Mammalian Target of Rapamycin (mTOR) Is Necessary for Hypoxia-Induced Pulmonary Artery Adventitial …
- Role of Phosphatidylinositol 3–kinase/AKT Pathway in Diffuse Large B-Cell Lymphoma Survival.
- Research Capsule Phosphatidylinositol 3–kinase: A Novel Effector
- Role of Phosphatidylinositol 3–kinase in platelet aggregation in type 1 diabetes mellitus
- Role of Phosphatidylinositol 3–kinase in oxidative stress-induced disruption of tight junctions. Vol. 278 (2003) 49239-49245
- Phosphatidylinositol 3–kinase p85 Subunit-Dependent Interaction with BCR/ABL: Molecular Mechanism and Biological Consequences.
- Oxygen, hypoxia-inducible factors, and Phosphatidylinositol 3–kinase/Akt signaling in tumor growth and gene expression.
- Atypical Protein kinase C (PKCλ/ζ) is a convergent downstream target of the insulin stimulated Phosphatidylinositol 3–kinase and TC10 signalling pathways
- Type I Transforming Growth Factor ك Receptor Binds to and Activates Phosphatidylinositol 3–kinase
- Specific Inhibition of p110δ Catalytic Subunit of Phosphatidylinositol 3‘-kinase With IC489666 Radiosensitizes Vascular Endothelium to Provide Improved Tumor …
- Phosphatidylinositol 3–kinase activator reduces motor neuronal cell death induced by G93A or A4V mutant SOD1 gene
- Expression and significance of Phosphatidylinositol 3–kinase in mammary atypical ductal hyperrlasia and cance
- Augmentation in inhibitory effect of sodium butyrate by Phosphatidylinositol 3–kinase inhibition in the human cervical cancer cells
- Role of Phosphatidylinositol 3–kinase in epinephrine and calcium ionophore, A 23187 induced platelet aggregation
- THE ROLE OF Phosphatidylinositol 3 kinase IN THE INDUCTION OF LIPOPOLYSACCHARIDE TOLERANCE AND PRIMING TOSTAPHYLOCOCCUS …
- UV-B Induced stimulation of Phosphatidylinositol 3–kinase in human fetal hepatocytes
- The Association of the Phosphatidylinositol–3–kinase Pathway to Gleason Score, Prostate-specific Antigen and Pathologic Stage in Prostate Cancer
- Bacterial Endotoxin and Staphylococcus aureus induced Tolerance and Priming, Implication of the Phosphatidylinositol–3 kinase Pathway: 262
- Overexpression of the N-terminal end of the p55y regulatory subunit of Phosphatidylinositol 3–kinase blocks cell cycle progression in gastric carcinoma cells
- Phosphatidylinositol 3–kinase and Protein kinase C as Molecular Determinants of Chemoresistance in Breast Cancer
- Nicotinic Receptor Stimulation Blocks Neurotoxicity Induced by Amyloid-ß via the Phosphatidylinositol–3–kinase Cascade
- … OF OOCYTES, SPERM-OOCYTE INTERACTIONS AND EARLY CLEAVAGE OF EMBRYOS IN MICE, ROLE OF Phosphatidylinositol 3–kinase, MOS, FAS-FAS …
- P-selectin activates leukocyte integrin alphaMbeta2 by recruiting Phosphatidylinositol–3 kinase to p-selectin glycoprotein ligand-1 cytoplasmic domain through adaptor …
- Mycobacteria-induced Interleukin-12 Expression by Human Monocyte-derived Macrophages Is Negatively Regulated by Phosphatidylinositol 3–kinase and ERK 1/2 …
- … ‐, or IL‐3‐dependent survival of macrophages, but not proliferation, requires the expression of p21Waf1 through the Phosphatidylinositol 3‐kinase/Akt pathway (Vol …
- Analysis of IRS-1-mediated Phosphatidylinositol 3–kinase activation in the adipose tissue of polycystic ovary syndrome patients complicated with insulin resistance
- Stretch-induced retinal vascular endothelial growth factor expression is mediated by Phosphatidylinositol 3–kinase and protein kinase C (PKC)-ζ but not by stretch …
- 459 EFFECT OF INSULIN ON ADIPONECTIN SECRETION FROM 3T3-L1 ADIPOCYTES IS Phosphatidylinositol 3–kinase DEPENDENT
- … apoptosis by GM-CSF as a result of temporary suppression of FADD recruitment in neutrophils: evidence implicating Phosphatidylinositol 3–kinase and MEK1-ERK1/2 …
- Relationship between neuroprotective effect of 17# beta#–estradiol and activity of Phosphatidylinositol—3—kinase
- … by GM-CSF as a result of temporary suppression of FADD recruitment in neutrophils: evidence implicating Phosphatidylinositol 3–kinase and MEK1-ERK1/2 …
- S 2-24: A protein kinase C superfamily member mediates invasive prostate cell growth downstream of activated Phosphatidylinositol 3–kinase
- … stress protection and increased cell proliferation induced by the protein p8 in INS-1 beta cells via activation of the Phosphatidylinositol–3‘-kinase and MAP kinase …
- AND-34-induced Rac activation and antiestrogen resistance in breast cancer requires Phosphatidylinositol 3–kinase
- The inhibitory effect of dibutyryl cyclic AMP on docosahexaenoic acid-induced apoptosis in HL-60 cells through activation of the Phosphatidylinositol–3 kinase pathway
- Cripto-1 Inhibits-Casein Expression in Mammary Epithelial Cells through a p21′-and Phosphatidylinositol 3‘-kinase-dependent Pathway1
- … Factor 1 Induced Expression of Vascular Endothelial Growth Factor, Which Is Dependent on MAP kinase and Phosphatidylinositol 3–kinase Signaling in Human …
- … -Induced Vascular Endothelial Growth Factor in Human Bone Marrow Stromal Cells, Which Is Involved in MAP kinase and Phosphatidylinositol 3–kinase …
- Study of the regulation of Fab1p, a Phosphatidylinositol 3-phosphate 5 kinase in Saccharomyces cerevisiae
- Characterisation of the Phosphatidylinositol–3-phosphate 5-kinase, Fab1, in Drosophila melanogaster
- Phosphatidylinositol 3‐kinase inhibitors: promising drug candidates for cancer therapy
- Cancer-specific mutations in Phosphatidylinositol 3–kinase
- Antitumor activity of ZSTK474, a new Phosphatidylinositol 3–kinase inhibitor
- Therapeutic potential of Phosphatidylinositol 3–kinase inhibitors in inflammatory respiratory disease
- Phosphatidylinositol 3–kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/Phosphatidylinositol 3–kinase inhibitor NVP-BEZ235
- Genetic alterations and their relationship in the Phosphatidylinositol 3–kinase/Akt pathway in thyroid cancer
- ZSTK474 is an ATP‐competitive inhibitor of class I Phosphatidylinositol 3 kinase isoforms
- Helical domain and kinase domain mutations in p110α of Phosphatidylinositol 3–kinase induce gain of function by different mechanisms
- Effect of the Phosphatidylinositol 3–kinase/Akt pathway on influenza A virus propagation
- Role of Phosphatidylinositol 3′-kinase/AKT pathway in diffuse large B-cell lymphoma survival
- Beclin 1 forms two distinct Phosphatidylinositol 3–kinase complexes with mammalian Atg14 and UVRAG
- Assortment of Phosphatidylinositol 3–kinase complexes—Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae
- Bivalent role of the Phosphatidylinositol‐3‐kinase (PI3K) during influenza virus infection and host cell defence
- Roles of Phosphatidylinositol 3–kinase in root hair growth
- Role of Phosphatidylinositol 3–kinase activation on insulin action and its alteration in diabetic conditions
- The Arabidopsis Phosphatidylinositol 3–kinase is important for pollen development
- Artery/vein specification is governed by opposing Phosphatidylinositol–3 kinase and MAP kinase/ERK signaling
- Cross-talk between the androgen receptor and the Phosphatidylinositol 3–kinase/Akt pathway in prostate cancer
- Targeting the Phosphatidylinositol 3–kinase pathway in multiple myeloma
- Clusterin activates survival through the Phosphatidylinositol 3–kinase/Akt pathway
- Phosphatidylinositol 3–kinase inhibition by LY294002 radiosensitizes human cervical cancer cell lines
- Regulation of hepatitis B virus replication by the Phosphatidylinositol 3–kinase-akt signal transduction pathway
- Cytokine stimulation promotes glucose uptake via Phosphatidylinositol–3 kinase/Akt regulation of Glut1 activity and trafficking
- Nutrients suppress Phosphatidylinositol 3–kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
- Activation of endothelial nitric oxide synthase by cilostazol via a cAMP/protein kinase A-and Phosphatidylinositol 3–kinase/Akt-dependent mechanism
- Regulation of class-switch recombination and plasma cell differentiation by Phosphatidylinositol 3–kinase signaling
- Differential association of Phosphatidylinositol 3–kinase, SHIP-1, and PTEN with forming phagosomes
- The Phosphatidylinositol 3–kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures
- Identification and characterization of NVP-BEZ235, a new orally available dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor with potent in …
- Dual regulatory roles of Phosphatidylinositol 3–kinase in IFN signaling
- High prevalence and mutual exclusivity of genetic alterations in the Phosphatidylinositol–3–kinase/akt pathway in thyroid tumors
- Activation of Phosphatidylinositol 3–kinase signaling by a mutant thyroid hormone β receptor
- Influenza A virus NS1 protein binds p85β and activates Phosphatidylinositol–3–kinase signaling
- Phosphatidylinositol 3–kinase/akt and ras/raf-mitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer
- Chronic kidney disease causes defects in signaling through the insulin receptor substrate/Phosphatidylinositol 3–kinase/Akt pathway: implications for muscle atrophy
- Hsp27 inhibits Bax activation and apoptosis via a Phosphatidylinositol 3–kinase-dependent mechanism
- Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of Phosphatidylinositol 3–kinase, Akt, and AS160
- PIK3CA cooperates with other Phosphatidylinositol 3′-kinase pathway mutations to effect oncogenic transformation
- Inhibition of Phosphatidylinositol 3–kinase Increases Efficacy of Cisplatin in in Vivo Ovarian Cancer Models
- Phosphatidylinositol 3′-kinase/AKT Signaling Is Activated in Medulloblastoma Cell Proliferation and Is Associated with Reduced Expression of PTEN
- Dysregulation of the Phosphatidylinositol 3–kinase pathway in thyroid neoplasia
- Inhibition of the Phosphatidylinositol‐3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma
- Association of PTEN gene methylation with genetic alterations in the Phosphatidylinositol 3‐kinase/AKT signaling pathway in thyroid tumors
- Integrative Genomic Analysis of Phosphatidylinositol 3′-kinase Family Identifies PIK3R3 as a Potential Therapeutic Target in Epithelial Ovarian Cancer
- Influenza A virus NS1 protein activates the Phosphatidylinositol 3–kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K
- Antigen receptor–mediated changes in glucose metabolism in B lymphocytes: role of Phosphatidylinositol 3–kinase signaling in the glycolytic control of growth
- Phosphatidylinositol 3–kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell …
- Erythropoietin involves the Phosphatidylinositol 3‐kinase pathway, 14‐3‐3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity
- Phosphatidylinositol 3–kinase is a key mediator of central sensitization in painful inflammatory conditions
- Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/Phosphatidylinositol 3–kinase-Akt pathways and up …
- Activation of the Phosphatidylinositol 3–kinase Vps34 by a G protein α subunit at the endosome
- Hypoxic regulation of vascular endothelial growth factor through the induction of Phosphatidylinositol 3–kinase/Rho/ROCK and c-Myc
- Oxidative stress stimulates skeletal muscle glucose uptake through a Phosphatidylinositol 3–kinase-dependent pathway
- Frequent PTEN genomic alterations and activated Phosphatidylinositol 3–kinase pathway in basal-like breast cancer cells
- Isoginkgetin inhibits tumor cell invasion by regulating Phosphatidylinositol 3–kinase/Akt–dependent matrix metalloproteinase-9 expression
- Induction of Phosphatidylinositol 3‐kinase‐mediated endocytosis by salt stress leads to intracellular production of reactive oxygen species and salt tolerance
- CCL2 protects prostate cancer PC3 cells from autophagic death via Phosphatidylinositol 3–kinase/AKT-dependent survivin up-regulation
- Arachidonic acid activates Phosphatidylinositol 3–kinase signaling and induces gene expression in prostate cancer
- Phosphatidylinositol 3–kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells
- Inhibition of Phosphatidylinositol 3–kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer
- Energy depletion inhibits Phosphatidylinositol 3–kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of …
- Highly prevalent genetic alterations in receptor tyrosine kinases and Phosphatidylinositol 3–kinase/akt and mitogen-activated protein kinase pathways in anaplastic …
- Inhibition of Phosphatidylinositol 3–kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma
- Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a Phosphatidylinositol 3–kinase/AKT/GSK-3β pathway and is antagonized by …
- ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, Phosphatidylinositol 3‐kinase/Akt, and mitogen‐activated protein kinase signaling …
- Targeting the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside
- Low-intensity pulsed ultrasound activates the Phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional …
- Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of Phosphatidylinositol 3′-kinase/Akt pathway and Bcl-2 family …
- … inhibitors used in treatment of Alzheimer’s disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and Phosphatidylinositol 3–kinase cascade
- Dual ERK and Phosphatidylinositol 3‐kinase pathways control airway smooth muscle proliferation: differences in asthma
- A conserved role for Phosphatidylinositol 3–kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy
- Effects of the dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging
- Human rhinovirus 1B exposure induces Phosphatidylinositol 3–kinase–dependent airway inflammation in mice
- Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when Phosphatidylinositol 3–kinase signaling is suppressed
- Rapid, nongenomic actions of retinoic acid on Phosphatidylinositol–3–kinase signaling pathway mediated by the retinoic acid receptor
- Phosphatidylinositol 3–kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity
- Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3–kinase/AKT pathway activation in human vestibular schwannoma
- Phosphatidylinositol 3–kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts
- Extracellular acidosis induces neutrophil activation by a mechanism dependent on activation of Phosphatidylinositol 3–kinase/Akt and ERK pathways
- Thyroid hormone regulates developmental titin isoform transitions via the Phosphatidylinositol–3–kinase/AKT pathway
- Blockage of epidermal growth factor receptor-Phosphatidylinositol 3–kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by …
- K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and Phosphatidylinositol 3–kinase signaling
- Class I and III Phosphatidylinositol 3′-kinase play distinct roles in TLR signaling pathway
- Gene silencing reveals a specific function of hVps34 Phosphatidylinositol 3–kinase in late versus early endosomes
- Mammalian target of rapamycin (mTOR) inhibition activates Phosphatidylinositol 3–kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute …
- Inhibition of the Phosphatidylinositol 3–kinase/mammalian target of rapamycin pathway in hematologic malignancies
- Phosphatidylinositol 3–kinase mediates activation of ATM by high NaCl and by ionizing radiation: Role in osmoprotective transcriptional regulation
- Phosphatidylinositol–3–kinase signaling mediates vascular smooth muscle cell expression of periostin in vivo and in vitro
- … stimulates cyclooxygenase-2 expression and increases bone formation through integrin, focal adhesion kinase, Phosphatidylinositol 3–kinase, and Akt pathway in …
- … hormone mediated changes in gene expression can be initiated by cytosolic action of the thyroid hormone receptor β through the Phosphatidylinositol 3–kinase …
- … of amygdala-dependent learning by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and Phosphatidylinositol–3–kinase
- Phosphatidylinositol 3–kinase/Akt pathway is involved in transforming growth factor-β1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells
- Interleukin (IL) 1β induction of IL-6 is mediated by a novel Phosphatidylinositol 3–kinase-dependent AKT/IκB kinase α pathway targeting activator protein-1
- Phosphatidylinositol–3–kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats
- Erythropoietin protects against doxorubicin-induced cardiomyopathy via a Phosphatidylinositol 3–kinase-dependent pathway
- Hypoxia up-regulates hypoxia-inducible factor-1α transcription by involving Phosphatidylinositol 3–kinase and nuclear factor κB in pulmonary artery smooth muscle …
- Phosphatidylinositol–3–kinase-γ is integral to homing functions of progenitor cells
- Interleukin-1β enhances GABAA receptor cell-surface expression by a Phosphatidylinositol 3–kinase/Akt pathway: relevance to sepsis-associated …
- TGF-β1 protects against Aβ-neurotoxicity via the Phosphatidylinositol–3–kinase pathway
- Upregulation of heme oxygenase-1 by Epigallocatechin-3-gallate via the Phosphatidylinositol 3–kinase/Akt and ERK pathways
- … activation of hypoxia-inducible factor-1α, vascular endothelial growth factor expression, and edema in the uterus are mediated by the Phosphatidylinositol 3–kinase …
- Verapamil toxicity dysregulates the Phosphatidylinositol 3‐kinase pathway
- Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering Phosphatidylinositol 3–kinase signaling and inducing Zac1 …
- Reelin signals through Phosphatidylinositol 3–kinase and Akt to control cortical development and through mTor to regulate dendritic growth
- FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of Phosphatidylinositol 3–kinase
- Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/Phosphatidylinositol 3–kinase/Akt2 feedback signaling
- … Protects Vascular Endothelial Cells against Apoptosis through a Gαi Protein-Dependent Activation of Phosphatidylinositol 3–kinase/Akt and Regulation of …
- Phosphatidylinositol 3–kinase/AKT signalling pathway components in human breast cancer: clinicopathological correlations
- … cultured cortical neurons from oxidative stress‐induced cell death through the activation of mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase
- Regulation of Phosphatidylinositol 3‐kinase (PI3K)/Akt and nuclear factor‐kappa B signaling pathways in dystrophin‐deficient skeletal muscle in response to …
- Yeast β-glucan amplifies phagocyte killing of iC3b-opsonized tumor cells via complement receptor 3-Syk-Phosphatidylinositol 3–kinase pathway
- Identification of survival‐related genes of the Phosphatidylinositol 3′‐kinase signaling pathway in glioblastoma multiforme
- Transforming growth factor β engages TACE and ErbB3 to activate Phosphatidylinositol–3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to …
- Involvement of Nrf2, p38, B-Raf, and nuclear factor-κB, but not Phosphatidylinositol 3–kinase, in induction of hemeoxygenase-1 by dietary polyphenols
- Wnt5a promotes adhesion of human dermal fibroblasts by triggering a Phosphatidylinositol–3 kinase/Akt signal
- Class IA Phosphatidylinositol 3–kinase: from their biologic implication in human cancers to drug discovery
- Phosphatidylinositol 3–kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells
- Phosphatidylinositol 3–kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer
- Diosgenin inhibits melanogenesis through the activation of Phosphatidylinositol–3–kinase pathway (PI3K) signaling.
- Phosphatidylinositol 3–kinase inhibition broadly sensitizes glioblastoma cells to death receptor–and drug-induced apoptosis
- Phosphatidylinositol 3–kinase Mediates Bronchioalveolar Stem Cell Expansion in Mouse Models of Oncogenic K-ras-Induced Lung Cancer
- The endogenous cannabinoid system stimulates glucose uptake in human fat cells via Phosphatidylinositol 3–kinase and calcium-dependent mechanisms
- NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and Phosphatidylinositol–3–kinase in human natural killer cells
- Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the Phosphatidylinositol 3–kinase/Akt/Rac1 signal pathway
- Gas6/Axl signaling activates the Phosphatidylinositol 3–kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factorα-induced apoptosis
- Tissue-and stimulus-dependent role of Phosphatidylinositol 3–kinase isoforms for neutrophil recruitment induced by chemoattractants in vivo
- Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of Phosphatidylinositol–3–kinase signaling and angiogenesis
- Estrogen receptor protein interaction with Phosphatidylinositol 3–kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the …
- … non-provitamin A carotenoid, lutein, inhibits NF-κB-dependent gene expression through redox-based regulation of the Phosphatidylinositol 3–kinase/PTEN/Akt and NF …
- Up-regulation of aldose reductase expression mediated by Phosphatidylinositol 3–kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative …
- Flow-Induced Cerebral Vasodilatation in Vivo Involves Activation of Phosphatidylinositol–3 kinase, NADPH-Oxidase, and Nitric Oxide Synthase
- Phosphorylation regulates tau interactions with Src homology 3 domains of Phosphatidylinositol 3–kinase, phospholipase Cγ1, Grb2, and Src family kinases
- Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a Phosphatidylinositol 3–kinase-dependent …
- Implication of the Phosphatidylinositol–3 kinase/protein kinase B signaling pathway in the neuroprotective effect of estradiol in the striatum of 1-methyl-4-phenyl-1, 2, 3 …
- Ginsenoside-Rg1 induces vascular endothelial growth factor expression through the glucocorticoid receptor-related Phosphatidylinositol 3–kinase/Akt and β …
- Gonadotropins activate proteolysis and increase invasion through protein kinase A and Phosphatidylinositol 3–kinase pathways in human epithelial ovarian cancer …
- Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via Phosphatidylinositol 3–kinase-dependent Rac1 activation
- C-Peptide induces vascular smooth muscle cell proliferation: involvement of SRC-kinase, Phosphatidylinositol 3–kinase, and extracellular signal-regulated kinase 1/2
- Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III Phosphatidylinositol 3–kinase
- Respiratory syncytial virus inhibits granulocyte apoptosis through a Phosphatidylinositol 3–kinase and NF-κB-dependent mechanism
- Epidermal growth factor stimulates Rac activation through Src and Phosphatidylinositol 3–kinase to promote colonic epithelial cell migration
- Elevated Phosphatidylinositol 3–kinase activation and its clinicopathological significance in cervical cancer
- Hypothalamic Phosphatidylinositol 3–kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB/N mice
- Phosphatidylinositol 3–kinase γ signaling through protein kinase Cζ induces NADPH oxidase-mediated oxidant generation and NF-κB activation in endothelial …
- Statin-induced Ras activation integrates the Phosphatidylinositol 3–kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast …
- … of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and Phosphatidylinositol 3–kinase signaling in cancer cells
- 17β-Estradiol abrogates apoptosis in murine skeletal muscle cells through estrogen receptors: role of the Phosphatidylinositol 3–kinase/Akt pathway
- ROS fusion tyrosine kinase activates a SH2 domain–containing phosphatase-2/Phosphatidylinositol 3–kinase/mammalian target of rapamycin signaling axis to form …
- Phosphatidylinositol 3–kinase γ is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning
- Synergistic collagenase expression and cartilage collagenolysis are Phosphatidylinositol 3–kinase/Akt signaling-dependent
- A ras inhibitor tilts the balance between Rac and Rho and blocks Phosphatidylinositol 3–kinase–dependent glioblastoma cell migration
- Phosphatidylinositol–3–kinase–atypical protein kinase C signaling is required for Wnt attraction and anterior–posterior axon guidance
- Effects of protein kinase and Phosphatidylinositol–3 kinase inhibitors on growth and ultrastructure of Trypanosoma cruzi
- Semaphorin 3B inhibits the Phosphatidylinositol 3–kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells
- Association between Phosphatidylinositol 3–kinase Regulatory Subunit p85α Met326Ile Genetic Polymorphism and Colon Cancer Risk
- … -δ agonist enhances vasculogenesis by regulating endothelial progenitor cells through genomic and nongenomic activations of the Phosphatidylinositol 3–kinase/Akt …
- Regulation of the Phosphatidylinositol 3–kinase-Akt and the mitogen-activated protein kinase pathways by ursolic acid in human endometrial cancer cells
- Leptin induces macrophage lipid body formation by a Phosphatidylinositol 3–kinase-and mammalian target of rapamycin-dependent mechanism
- The Phosphatidylinositol 3–kinase/Akt pathway negatively regulates Nod2-mediated NF-κB pathway
- Inhibition of mammalian target of rapamycin induces Phosphatidylinositol 3–kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E …
- Phosphatidylinositol 3–kinase (PI3K) inhibitors as anticancer drugs
- Role of MyD88 in Phosphatidylinositol 3–kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells
- Practicalities of drugging the Phosphatidylinositol–3–kinase/Akt cell survival signaling pathway
- Epigallocatechin‐3‐gallate diminishes CCL2 expression in human osteoblastic cells via up‐regulation of Phosphatidylinositol 3‐kinase/Akt/Raf‐1 interaction: a …
- Basal B cell receptor-directed Phosphatidylinositol 3–kinase signaling turns off RAGs and promotes B cell-positive selection
- Requirement of Phosphatidylinositol 3–kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-β in human …
- Polycystin-1 induces resistance to apoptosis through the Phosphatidylinositol 3–kinase/Akt signaling pathway
- Syk associates with clathrin and mediates Phosphatidylinositol 3–kinase activation during human rhinovirus internalization
- Axl/Phosphatidylinositol 3–kinase signaling inhibits mineral deposition by vascular smooth muscle cells
- The involvement of Phosphatidylinositol 3–kinase/Akt signaling in high glucose-induced downregulation of GLUT-1 expression in ARPE cells
- Cartducin stimulates mesenchymal chondroprogenitor cell proliferation through both extracellular signal‐regulated kinase and Phosphatidylinositol 3‐kinase/Akt …
- Disrupted RabGAP function of the p85 subunit of Phosphatidylinositol 3–kinase results in cell transformation
- Phosphatidylinositol 3–kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation
- Phosphatidylinositol 3–kinase/Akt pathway regulates hepatic stellate cell apoptosis
- Src-family tyrosine kinase fyn phosphorylates Phosphatidylinositol 3–kinase enhancer-activating Akt, preventing its apoptotic cleavage and promoting cell …
- Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via Phosphatidylinositol 3–kinase-and phosphodiesterase 3-mediated …
- Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the Phosphatidylinositol 3–kinase cell survival pathway
- CpG DNA activates survival in murine macrophages through TLR9 and the Phosphatidylinositol 3–kinase-Akt pathway
- A Phosphatidylinositol–3–kinase-dependent signal transition regulates ARF1 and ARF6 during Fcγ receptor-mediated phagocytosis
- CTLA-4 activation of Phosphatidylinositol 3–kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death
- Inhibition of Phosphatidylinositol 3–kinase-mediated glucose metabolism coincides with resveratrol-induced cell cycle arrest in human diffuse large B-cell lymphomas
- Selective regulation of CD8 effector T cell migration by the p110γ isoform of Phosphatidylinositol 3–kinase
- Activation of STAT3 by Gαs distinctively requires protein kinase A, JNK, and Phosphatidylinositol 3–kinase
- Involvement of multiple Phosphatidylinositol 3–kinase-dependent pathways in the persistence of late-phase long term potentiation expression
- Involvement of Phosphatidylinositol 3–kinase-mediated up-regulation of IκBα in anti-inflammatory effect of gemfibrozil in microglia
- Down-regulation of Phosphatidylinositol 3′-kinase/AKT/molecular target of rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer
- Structure/function analysis of the Phosphatidylinositol–3–kinase domain of yeast tra1
- Roles of Phosphatidylinositol 3–kinase and NF-κB in human cytomegalovirus-mediated monocyte diapedesis and adhesion: strategy for viral persistence
- Emodin accelerates osteoblast differentiation through Phosphatidylinositol 3–kinase activation and bone morphogenetic protein-2 gene expression
- Intracellular network of Phosphatidylinositol 3‐kinase, mammalian target of the rapamycin/70 kDa ribosomal S6 kinase 1, and mitogen‐activated protein kinases …
- Vascular endothelial growth factor protects spinal cord motoneurons against glutamate‐induced excitotoxicity via Phosphatidylinositol 3‐kinase
- Phosphatidylinositol 3–kinase activation is required to form the NKG2D immunological synapse
- A peptide inhibitor derived from p55PIK Phosphatidylinositol 3–kinase regulatory subunit: a novel cancer therapy
- Phosphatidylinositol 3–kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes
- Role of nongenomic activation of Phosphatidylinositol 3–kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular …
- Activation of Phosphatidylinositol 3–kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve …
- IL‐21 promotes T lymphocyte survival by activating the Phosphatidylinositol‐3 kinase signaling cascade
- Phosphatidylinositol 3–kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in …
- … -2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor–mediated p38/Akt and Phosphatidylinositol 3–kinase/Akt signaling pathways
- Involvement of Bcl-2 family members, Phosphatidylinositol 3‘-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer
- Mechanism of influenza A virus NS1 protein interaction with the p85β, but not the p85α, subunit of Phosphatidylinositol 3–kinase (PI3K) and up-regulation of …
- … is dependent on sphingosine kinase-mediated activation of Phosphatidylinositol phospholipase C, protein kinase C, ERK1/2, and Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase (PI3K) signaling and regulation of the antibody response
- Ginsenoside Rb1 preconditioning protects against myocardial infarction after regional ischemia and reperfusion by activation of Phosphatidylinositol–3–kinase signal …
- Inhibition of the Phosphatidylinositol 3–kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosis
- Interferon-γ induces human vascular smooth muscle cell proliferation and intimal expansion by Phosphatidylinositol 3–kinase–dependent mammalian target of …
- Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring Phosphatidylinositol 3–kinase and c-Myc
- Phosphatidylinositol 3–kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for α-platelet-derived growth factor receptor-induced …
- Localization of Fas/CD95 into the lipid rafts on down-modulation of the Phosphatidylinositol 3–kinase signaling pathway
- … 3-gallate suppresses heregulin-β1-induced fatty acid synthase expression in human breast cancer cells by inhibiting Phosphatidylinositol 3–kinase/Akt and mitogen …
- Phosphatidylinositol–3–kinase activation blocks amyloid beta-induced neurotoxicity
- In vivo Functional Analysis of the Counterbalance of Hyperactive Phosphatidylinositol 3–kinase p110 Catalytic Oncoproteins by the Tumor Suppressor PTEN
- Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active Phosphatidylinositol 3–kinase γ
- Role of the Phosphatidylinositol 3–kinase and mTOR pathways in the regulation of renal fibroblast function and differentiation
- GM1‐induced activation of Phosphatidylinositol 3‐kinase: involvement of Trk receptors
- Cancer cell-derived clusterin modulates the Phosphatidylinositol 3′-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation
- Phosphatidylinositol 3–kinase signaling in mammalian preimplantation embryo development
- Activation of Phosphatidylinositol 3–kinase/protein kinase B pathway by a vanadyl compound mediates its neuroprotective effect in mouse brain ischemia
- Role of crosstalk between Phosphatidylinositol 3–kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery–vein …
- Isoorientin induces Nrf2 pathway-driven antioxidant response through Phosphatidylinositol 3–kinase signaling
- Activation of Rac by cadherin through the c-Src–Rap1–Phosphatidylinositol 3–kinase–Vav2 pathway
- Phosphatidylinositol 3–kinase is necessary for lens fiber cell differentiation and survival
- Early Phosphatidylinositol 3–kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death
- Phosphorylation of MNAR promotes estrogen activation of Phosphatidylinositol 3–kinase
- Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/Phosphatidylinositol 3–kinase/Glut4 pathway
- Caspase-8 interacts with the p85 subunit of Phosphatidylinositol 3–kinase to regulate cell adhesion and motility
- Role of Focal adhesion kinase and Phosphatidylinositol 3′-kinase in integrin fibronectin receptor-mediated, matrix metalloproteinase-1–dependent invasion by …
- Dietary flavonoid (−) epicatechin stimulates Phosphatidylinositol 3‐kinase‐dependent anti‐oxidant response element activity and up‐regulates glutathione in cortical …
- Inhibition of the Phosphatidylinositol 3–kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens
- Phosphatidylinositol 3–kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells
- … -induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1α and Sp1 through the Phosphatidylinositol 3–kinase/Akt signaling pathway
- Ca2+-regulated Pool of Phosphatidylinositol–3-phosphate Produced by Phosphatidylinositol 3–kinase C2α on Neurosecretory Vesicles
- Sevoflurane post‐conditioning protects against myocardial reperfusion injury by activation of Phosphatidylinositol‐3‐kinase signal transduction
- Inhibition of Phosphatidylinositol–3–kinase and mitogen-activated protein kinase kinase 1/2 prevents melanoma development and promotes melanoma regression in …
- BCR-ABL regulates Phosphatidylinositol 3–kinase-p110γ transcription and activation and is required for proliferation and drug resistance
- Estrogen facilitates both Phosphatidylinositol 3–kinase/Akt and ERK1/2 mitogen-activated protein kinase membrane signaling required for long-term neuropeptide Y …
- Oleic acid enhances vascular smooth muscle cell proliferation via Phosphatidylinositol 3–kinase/Akt signaling pathway
- Combined inhibition of the Phosphatidylinositol 3–kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells
- Nitric oxide synthesis is required for exercise-induced increases in hippocampal BDNF and Phosphatidylinositol 3′ kinase expression
- Serotonin-induced growth of pulmonary artery smooth muscle requires activation of Phosphatidylinositol 3–kinase/serine-threonine protein kinase B/mammalian target …
- The recruitment of Phosphatidylinositol 3–kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C …
- Transcriptome analysis of NF-κB-and Phosphatidylinositol 3–kinase-regulated genes in human cytomegalovirus-infected monocytes
- Activation of Phosphatidylinositol 3–kinase by membrane localization of p110α predisposes mammary glands to neoplastic transformation
- Class IB-Phosphatidylinositol 3–kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion
- Parallel Phosphatidylinositol 3–kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis
- CEACAM1 (CD66a) promotes human monocyte survival via a Phosphatidylinositol 3–kinase-and AKT-dependent pathway
- Class I Phosphatidylinositol 3‐kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901
- NMDA neuroprotection against a Phosphatidylinositol‐3 kinase inhibitor, LY294002 by NR2B‐mediated suppression of glycogen synthase kinase‐3β‐induced …
- … suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein α by Phosphatidylinositol 3–kinase …
- The p110γ isoform of Phosphatidylinositol 3‐kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites
- … of brain-derived neurotrophic factor against hypoxic injury in vitro requires activation of extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase facilitates bile acid-induced Ca2+ responses in pancreatic acinar cells
- Leptin-induced IL-6 production is mediated by leptin receptor, insulin receptor substrate-1, Phosphatidylinositol 3–kinase, Akt, NF-κB, and p300 pathway in microglia
- Coculture with endothelial cells enhances vascular smooth muscle cell adhesion and spreading via activation of β1-integrin and Phosphatidylinositol 3–kinase/Akt
- Regulation of Akt/PKB by Phosphatidylinositol 3‐kinase‐dependent and‐independent pathways in B‐cell chronic lymphocytic leukemia cells: role of protein kinase Cβ
- The noncoding RNA, miR‐126, suppresses the growth of neoplastic cells by targeting Phosphatidylinositol 3‐kinase signaling and is frequently lost in colon cancers
- Activation of Phosphatidylinositol 3–kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses
- The Phosphatidylinositol 3–kinase/akt signaling pathway in medullary thyroid cancer
- Insulin induces heme oxygenase‐1 through the Phosphatidylinositol 3‐kinase/Akt pathway and the Nrf2 transcription factor in renal cells
- Phosphatidylinositol 3–kinase/Akt signaling mediates interleukin-32α induction in human pancreatic periacinar myofibroblasts
- … response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of Phosphatidylinositol 3–kinase and Nrf2 signaling
- c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the Phosphatidylinositol 3–kinase (PI3K)-AKT pathway
- Latent membrane protein 1 of EBV activates Phosphatidylinositol 3–kinase to induce production of IL-10
- Alterations of Phosphatidylinositol 3‐kinase pathway components in epilepsy‐associated glioneuronal lesions
- … cell invasion and cord formation by promoting matrix metalloproteinase-2 expression through the Phosphatidylinositol 3–kinase/Akt signaling pathway and AP …
- Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the Phosphatidylinositol 3–kinase, p38 MAPK, and ERK1/2 …
- Altered regulation of Phosphatidylinositol 3–kinase signaling in cathepsin D-deficient brain
- Phosphatidylinositol 3′-kinase is a critical mediator of interferon-γ-induced increases in enteric epithelial permeability
- Role of Phosphatidylinositol‐3 kinase/Akt pathway in bladder cancer cell apoptosis induced by tumor necrosis factor‐related apoptosis‐inducing ligand
- Follicle-stimulating hormone-induced aromatase in immature rat Sertoli cells requires an active Phosphatidylinositol 3–kinase pathway and is inhibited via the mitogen …
- Role of RacC for the regulation of WASP and Phosphatidylinositol 3–kinase during chemotaxis of Dictyostelium
- Phosphatidylinositol 3–kinase in breast cancer: where from here?
- Pyranone, thiopyranone, and pyridone inhibitors of Phosphatidylinositol 3–kinase related kinases. Structure− activity relationships for DNA-dependent protein kinase …
- Nuclear receptor corepressor is a novel regulator of Phosphatidylinositol 3–kinase signaling
- Raft-dependent endocytosis of autocrine motility factor is Phosphatidylinositol 3–kinase-dependent in breast carcinoma cells
- Polyunsaturated fatty acids block platelet-activating factor-induced Phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells
- Fatty acids differentially influence Phosphatidylinositol 3–kinase signal transduction in endothelial cells: impact on adhesion and apoptosis
- … UVB-Induced Inflammatory Cylooxygenase-2 Gene Expression and PGE2 Production through Regulation of the Nuclear Factor-κB and Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3–kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1
- Formyl peptide receptor-1 activation enhances intestinal epithelial cell restitution through Phosphatidylinositol 3–kinase-dependent activation of Rac1 and Cdc42
- Targeted RNA interference of Phosphatidylinositol 3‐kinase p110‐β induces apoptosis and proliferation arrest in endometrial carcinoma cells
- Enhanced neutrophil motility by granulocyte colony‐stimulating factor: the role of extracellular signal‐regulated kinase and Phosphatidylinositol 3‐kinase
- Fibroblast growth factor-2 is a downstream mediator of Phosphatidylinositol 3–kinase-Akt signaling in 14, 15-epoxyeicosatrienoic acid-induced angiogenesis
- Adhesion-related kinase induction of migration requires Phosphatidylinositol–3–kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing …
- Inhibition of the Phosphatidylinositol 3′-kinase Pathway Promotes Autocrine Fas-Induced Death of Phosphatase and Tensin Homologue–Deficient Prostate Cancer …
- Insulin‐like growth factor‐1‐dependent maintenance of neuronal metabolism through the Phosphatidylinositol 3‐kinase–Akt pathway is inhibited by C2‐ceramide in …
- Non-Opsonic Phagocytosis of Legionella pneumophila by Macrophages Is Mediated by Phosphatidylinositol 3–kinase
- Herpes Simplex Virus Us3 (−) Mutant as Oncolytic Strategy and Synergizes with Phosphatidylinositol 3–kinase-Akt–Targeting Molecular Therapeutics
- Coxsackievirus B3 activates nuclear factor kappa B transcription factor via a Phosphatidylinositol‐3 kinase/protein kinase B‐dependent pathway to improve host cell …
- Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK-and Phosphatidylinositol 3–kinase/protein kinase B …
- Iron causes interactions of TAK1, p21ras, and Phosphatidylinositol 3–kinase in caveolae to activate IκB kinase in hepatic macrophages
- Insulin-like growth factor II activates Phosphatidylinositol 3–kinase-protooncogenic protein kinase 1 and mitogen-activated protein kinase cell signaling pathways, and …
- Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting Phosphatidylinositol 3–kinase neuroprotective signaling
- Phosphatidylinositol 3–kinase regulation of gastrin-releasing peptide-induced cell cycle progression in neuroblastoma cells
- Epigallocatechin gallate stimulates glucose uptake through the Phosphatidylinositol 3–kinase-mediated pathway in L6 rat skeletal muscle cells
- Regulation of pancreatic duct cell differentiation by Phosphatidylinositol–3 kinase
- Granulocyte colony-stimulating factor mediates cardioprotection against ischemia/reperfusion injury via Phosphatidylinositol–3–kinase/Akt pathway in canine hearts
- Reduced insulin‐induced Phosphatidylinositol‐3‐kinase activation in peripheral blood mononuclear leucocytes from patients with Alzheimer’s disease
- Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3), a modulator of the Phosphatidylinositol–3–kinase/Akt …
- Phagocytosis by Lymnaea stagnalis haemocytes: a potential role for Phosphatidylinositol 3–kinase but not protein kinase A
- Lithium protection of phencyclidine-induced neurotoxicity in developing brain: The role of Phosphatidylinositol–3 kinase/Akt and mitogen-activated protein kinase …
- Glucocorticoid conditioning of myeloid progenitors enhances TLR4 signaling via negative regulation of the Phosphatidylinositol 3–kinase-Akt pathway
- Erythropoietin protects the human myocardium against hypoxia/reoxygenation injury via Phosphatidylinositol‐3 kinase and ERK1/2 activation
- Centaurin-α1 is a Phosphatidylinositol 3–kinase-dependent activator of ERK1/2 mitogen-activated protein kinases
- Thrifty metabolism that favors fat storage after caloric restriction: a role for skeletal muscle Phosphatidylinositol‐3‐kinase activity and AMP‐activated protein kinase
- Transforming growth factor β activation of c-Abl is independent of receptor internalization and regulated by Phosphatidylinositol 3–kinase and PAK2 in …
- Phosphatidylinositol 3–kinase and p38 mitogen-activated protein kinase regulate induction of Mcl-1 and survival in glucocorticoid-treated human neutrophils
- … -II is increased in systemic sclerosis-associated pulmonary fibrosis and contributes to the fibrotic process via Jun N-terminal kinase-and Phosphatidylinositol–3 kinase …
- … endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered Phosphatidylinositol 3–kinase/Akt pathway: reversal …
- Phosphatidylinositol 3–kinase-dependent transcriptional silencing of the translational repressor 4E-BP1
- Phosphatidylinositol 3–kinase/Akt activation by integrin-tumor matrix interaction suppresses Fas-mediated apoptosis in T cells
- Simultaneous inhibition of the mitogen‐activated protein kinase kinase and Phosphatidylinositol 3′‐kinase pathways enhances sensitivity to paclitaxel in ovarian …
- RhoG regulates anoikis through a Phosphatidylinositol 3–kinase-dependent mechanism
- … corticotropin-releasing hormone-R1α-mitogen-activated protein kinase (MAPK) interactions: the critical role of Phosphatidylinositol 3–kinase in regulating ERK1/2 but …
- Angiotensin II suppresses adriamycin‐induced apoptosis through activation of Phosphatidylinositol 3‐kinase/Akt signaling in human breast cancer cells
- CD160-activating NK cell effector functions depend on the Phosphatidylinositol 3–kinase recruitment
- Melatonin stimulates glucose transport via insulin receptor substrate‐1/Phosphatidylinositol 3‐kinase pathway in C2C12 murine skeletal muscle cells
- Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via Phosphatidylinositol 3–kinase/Akt signaling in pulmonary artery …
- Requirement of Ca2+ influx- and Phosphatidylinositol 3–kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity
- Phosphatidylinositol 3‐kinase pathway regulates sperm viability but not capacitation on boar spermatozoa
- Peroxisome proliferator–activated receptor γ regulates angiotensin II–stimulated Phosphatidylinositol 3–kinase and mitogen-activated protein kinase in blood vessels …
- Rhinovirus activates interleukin-8 expression via a Src/p110β Phosphatidylinositol 3–kinase/Akt pathway in human airway epithelial cells
- Crystal‐induced neutrophil activation. IX. Syk‐dependent activation of class Ia Phosphatidylinositol 3‐kinase
- Makorin-2 is a neurogenesis inhibitor downstream of Phosphatidylinositol 3–kinase/Akt (PI3K/Akt) signal
- Enhanced anti‐cancer effect of a Phosphatidylinositol‐3 kinase inhibitor and doxorubicin on human breast epithelial cell lines with different p53 and oestrogen …
- Decreased l-Type Ca2+ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3–kinase Signaling
- Gastrin-releasing peptide receptors regulate proliferation of C6 glioma cells through a Phosphatidylinositol 3–kinase-dependent mechanism
- The anti-apoptotic effect of leukotriene B4 in neutrophils: a role for Phosphatidylinositol 3–kinase, extracellular signal-regulated kinase and Mcl-1
- Enhancement of cytokine-mediated NF-κB activation by Phosphatidylinositol 3–kinase inhibitors in monocytic cells
- … -promoting domains of neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, and involvement of Phosphatidylinositol 3–kinase and protein kinase …
- Phosphatidylinositol 3–kinase signaling in proliferating cells maintains an anti-apoptotic transcriptional program mediated by inhibition of FOXO and non …
- The proangiogenic phenotype of human tumor-derived endothelial cells depends on thrombospondin-1 downregulation via Phosphatidylinositol 3–kinase/Akt pathway
- Tissue kallikrein reverses insulin resistance and attenuates nephropathy in diabetic rats by activation of Phosphatidylinositol 3–kinase/protein kinase B and adenosine …
- Down-regulation of apolipoprotein M expression is mediated by Phosphatidylinositol 3–kinase in HepG2 cells
- Phosphatidylinositol–3–kinase regulates scavenger receptor class B type I subcellular localization and selective lipid uptake in hepatocytes
- Expression of insulin-like growth factor binding protein-2 by MCF-7 breast cancer cells is regulated through the Phosphatidylinositol 3–kinase/AKT/mammalian target of …
- Protein chip discovery of secreted proteins regulated by the Phosphatidylinositol 3–kinase pathway in ovarian cancer cell lines
- 2‐Methoxyestradiol attenuates Phosphatidylinositol 3‐kinase/Akt pathway‐mediated metastasis of gastric cancer
- … antiapoptotic signaling pathways activated by vasoactive intestinal polypeptide, epidermal growth factor, and Phosphatidylinositol 3–kinase in prostate cancer …
- A Trypanosoma cruzi Phosphatidylinositol 3–kinase (TcVps34) is involved in osmoregulation and receptor-mediated endocytosis
- Involvement of Phosphatidylinositol–3 kinase–Akt and nuclear factor kappa-B pathways in the effect of frutalin on human lymphocyte
- Identification and classification of genes regulated by Phosphatidylinositol 3–kinase-and TRKB-mediated signalling pathways during neuronal differentiation in …
- Sustained activation of Phosphatidylinositol 3–kinase/Akt/nuclear factor κB signaling mediates G protein-coupled δ-opioid receptor gene expression
- Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the Phosphatidylinositol 3–kinase/Akt pathway in multiple myeloma cells
- Regulation of heme oxygenase-1 gene expression through the Phosphatidylinositol 3–kinase/PKC-ζ pathway and Sp1
- … signature of epidermal keratinocytes subjected to in vitro scratch wounding reveals selective roles for ERK1/2, p38, and Phosphatidylinositol 3–kinase …
- ADP-ribosylation factor 1 controls the activation of the Phosphatidylinositol 3–kinase pathway to regulate epidermal growth factor-dependent growth and …
- Blockade of the Phosphatidylinositol–3–kinase–Akt signaling pathway enhances the induction of apoptosis by microtubule-destabilizing agents in tumor cells in which …
- Phosphatidylinositol 3–kinase functions as a Ras effector in the signaling cascade that regulates dephosphorylation of the actin-remodeling protein cofilin after …
- Neuroprotective effect of the stearic acid against oxidative stress via Phosphatidylinositol 3–kinase pathway
- The p85α Subunit of Class IA Phosphatidylinositol 3–kinase Regulates the Expression of Multiple Genes Involved in Osteoclast Maturation and Migration
- Differential roles of Phosphatidylinositol 3–kinase/akt pathway in retinal ganglion cell survival in rats with or without acute ocular hypertension
- SREBP-1 regulates the expression of heme oxygenase 1 and the Phosphatidylinositol–3 kinase regulatory subunit p55γ
- Synergistic interaction between 17‐AAG and Phosphatidylinositol 3‐kinase inhibition in human malignant glioma cells
- Augmentation of sodium butyrate-induced apoptosis by Phosphatidylinositol 3–kinase inhibition in the human cervical cancer cell-line
- Phosphatidylinositol 3–kinase/protein kinase Cζ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor …
- Roles of Phosphatidylinositol 3–kinase-Akt and NADPH Oxidase in Adenosine 5′-Triphosphate–Sensitive K+ Channel Function Impaired by High Glucose in the …
- Activation of Phosphatidylinositol 3–kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumors
- … matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and Phosphatidylinositol 3–kinase pathways in human …
- Involvement of Phosphatidylinositol–3 kinase/AKT/PKCζ/λ pathway in the effect of palmitate on glucose-induced insulin secretion
- Phosphatidylinositol 3–kinase-dependent suppression of the human inducible nitric-oxide synthase promoter is mediated by FKHRL1
- Phosphatidylinositol 3–kinase and Akt nonautonomously promote perineurial glial growth in Drosophila peripheral nerves
- Adipose tissue compensates for defect of Phosphatidylinositol 3′-kinase induced in liver and muscle by dietary fish oil in fed rats
- Prolactin activates mammalian target-of-rapamycin through Phosphatidylinositol 3–kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 …
- Regulation of Phosphatidylinositol 3–kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury
- The vitamin D receptor‐mediated activation of Phosphatidylinositol 3‐kinase (PI3Kα) plays a role in the 1α,25‐dihydroxyvitamin D3‐stimulated increase in steroid …
- Transforming growth factor-β3 increases the invasiveness of endometrial carcinoma cells through Phosphatidylinositol 3–kinase-dependent up-regulation of X …
- Thyroid hormone rapidly stimulates alveolar Na, K-ATPase by activation of Phosphatidylinositol 3–kinase
- Dehydroepiandrosterone Stimulates Phosphorylation of FoxO1 in Vascular Endothelial Cells via Phosphatidylinositol 3–kinase-and Protein kinase A …
- Insulin activates hypoxia-inducible factor-1α in human and rat vascular smooth muscle cells via Phosphatidylinositol–3 kinase and mitogen-activated protein …
- Up-regulation of the Phosphatidylinositol 3–kinase/protein kinase B pathway in the ovary of rats by chronic treatment with hCG and insulin
- Insulin-stimulated insulin receptor substrate-2–associated Phosphatidylinositol 3–kinase activity is enhanced in human skeletal muscle after exercise
- High glucose enhances transient receptor potential channel canonical type 6–dependent calcium influx in human platelets via Phosphatidylinositol 3–kinase …
- Critical Role of the Phosphatidylinositol 3–kinase/Akt/Glycogen Synthase kinase–3β Signaling Pathway in Recovery from Anthrax Lethal Toxin-induced Cell …
- Phosphatidylinositol 3–kinase activity and asymmetrical accumulation of F-actin are necessary for establishment of cell polarity in the early development of …
- Phosphatidylinositol 3–kinase-mediated regulation of IL-10 and IL-12 production in macrophages stimulated with CpG oligodeoxynucleotide
- IL-7 activates the Phosphatidylinositol 3–kinase/AKT pathway in normal human thymocytes but not normal human B cell precursors
- Requirements of Phosphatidylinositol–3 kinase and mammalian target of rapamycin for estrogen-induced proliferation in uterine leiomyoma-and myometrium-derived …
- Rotavirus replication in intestinal cells differentially regulates integrin expression by a Phosphatidylinositol 3–kinase-dependent pathway, resulting in increased cell …
- … hydrogen peroxide regulates glutathione redox via nuclear factor erythroid 2-related factor 2 downstream of Phosphatidylinositol 3–kinase during muscle differentiation
- Dual roles of IL-15 in maintaining IL-7RαlowCCR7− memory CD8+ T cells in humans via recovering the Phosphatidylinositol 3–kinase/AKT pathway
- Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF-β and Phosphatidylinositol 3–kinase activity
- Upregulation of heme oxygenase-1 by brazilin via the Phosphatidylinositol 3–kinase/Akt and ERK pathways and its protective effect against oxidative injury
- CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on Phosphatidylinositol 3–kinase, Vav-1, Cdc42, and myosin light chain kinase
- A comprehensive analysis of transcript signatures of the Phosphatidylinositol‐3 kinase/protein kinase B signal‐transduction pathway in prostate cancer
- The hormonal response of estrogen receptor β is decreased by the Phosphatidylinositol 3–kinase/Akt pathway via a phosphorylation-dependent release of …
- … primary endothelial cells are essential for Kaposi’s sarcoma-associated herpesvirus/human herpesvirus 8-induced Phosphatidylinositol 3–kinase and RhoA-GTPases …
- Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the Phosphatidylinositol 3–kinase-, Akt-, and NF-κB-dependent pathway
- APOE4-VLDL Inhibits the HDL-Activated Phosphatidylinositol 3–kinase/Akt Pathway via the Phosphoinositol Phosphatase SHIP2
- Signaling through the Phosphatidylinositol 3–kinase regulates mechanotaxis induced by local low magnetic forces in Entamoeba histolytica
- Effect of estrogen and inhibition of Phosphatidylinositol–3 kinase on Akt and FOXO1 in rat uterus
- Leptin inhibits apoptosis in thymus through a janus kinase-2-independent, insulin receptor substrate-1/Phosphatidylinositol–3 kinase-dependent pathway
- Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the Phosphatidylinositol 3′-kinase
- B cell receptor signaling down-regulates forkhead box transcription factor class O 1 mRNA expression via Phosphatidylinositol 3–kinase and Bruton’s tyrosine kinase
- Phosphatidylinositol 3–kinase–dependent activation of akt, an essential signal for hyperthermia-induced heat-shock protein 72, is attenuated in streptozotocin-induced …
- CAL-101, a potent selective inhibitor of the p110d isoform of Phosphatidylinositol 3–kinase, attenuates PI3K signaling and inhibits proliferation and survival of Acute …
- Differential regulation of the IL-17 receptor by γc cytokines: inhibitory signaling by the Phosphatidylinositol 3–kinase pathway
- … by Activating Extracellular Signal-regulated kinase 1/2 and c-Jun NH2-Terminal kinase Downstream of Phosphatidylinositol 3–kinase and Mammalian Target of …
- The p110α isoform of Phosphatidylinositol 3–kinase is essential for polyomavirus middle T antigen-mediated transformation
- Focal adhesion kinase mediates the interferon‐γ‐inducible GTPase‐induced Phosphatidylinositol 3‐kinase/Akt survival pathway and further initiates a positive …
- Phosphatidylinositol 3–kinase/Akt signaling stimulates colonic mucosal cell survival during aging
- The cytomegalovirus homolog of interleukin-10 requires Phosphatidylinositol 3–kinase activity for inhibition of cytokine synthesis in monocytes
- Pleckstrin-2 selectively interacts with Phosphatidylinositol 3–kinase lipid products and regulates actin organization and cell spreading
- … CB1 receptor antagonist rimonabant stimulates 2-deoxyglucose uptake in skeletal muscle cells by regulating the expression of Phosphatidylinositol–3–kinase
- Adenosine induces hemeoxygenase‐1 expression in microglia through the activation of Phosphatidylinositol 3‐kinase and nuclear factor E2‐related factor 2
- Leptin stimulates α1 (I) collagen expression in human hepatic stellate cells via the Phosphatidylinositol 3‐kinase/Akt signalling pathway
- Cyclin D3 expression in melanoma cells is regulated by adhesion-dependent Phosphatidylinositol 3–kinase signaling and contributes to G1-S progression
- Bis (1-oxy-2-pyridinethiolato) oxovanadium (IV) enhances neurogenesis via Phosphatidylinositol 3–kinase/Akt and extracellular signal regulated kinase activation in …
- Activity of the p110-α subunit of Phosphatidylinositol–3–kinase is required for activation of epithelial sodium transport
- Nitric oxide mediates stretch-induced Ca2+ release via activation of Phosphatidylinositol 3–kinase-Akt pathway in smooth muscle
- FGF-2-induced wound healing in corneal endothelial cells requires Cdc42 activation and Rho inactivation through the Phosphatidylinositol 3–kinase pathway
- Roles of Phosphatidylinositol 3–kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium
- … and activator of transcription 3, mitogen-activated protein kinase/extracellularly regulated kinase 1/2, and Phosphatidylinositol 3–kinase/Akt signaling pathways
- Activation of Phosphatidylinositol–3 kinase regulates pancreatic duodenal homeobox-1 in duct cells during pancreatic regeneration
- Effect of a fungal immunomodulatory protein from Ganoderma tsugae on cell cycle and interferon-gamma production through Phosphatidylinositol 3–kinase signal …
- Retinol decreases Phosphatidylinositol 3‐kinase activity in colon cancer cells
- Enhanced susceptibility to apoptosis of oral squamous cell carcinoma cells subjected to combined treatment with anticancer drugs and Phosphatidylinositol 3–kinase …
- Mitogen-activated protein kinase (MAPK) and Phosphatidylinositol–3 kinase (PI3K) pathways differently regulate retinal pigment epithelial cell-mediated collagen gel …
- Involvement of Phosphatidylinositol–3–kinase and ERK pathways in the production of TGF-β1 by macrophages treated with liposomes composed of …
- Improved poststorage cardiac function by poly (ADP-ribose) polymerase inhibition: role of Phosphatidylinositol 3–kinase Akt pathway
- Phosphatidylinositol 3‐kinase/Akt plays a role in sphingosine 1‐phosphate‐stimulated HSP27 induction in osteoblasts
- Estradiol regulates the insulin-like growth factor-I (IGF-I) signalling pathway: a crucial role of Phosphatidylinositol 3–kinase (PI 3–kinase) in estrogens requirement for …
- … is associated with elevated peroxisome proliferator-activated receptor γ: regulation by prostaglandin E2 via the Phosphatidylinositol 3–kinase and Akt pathway
- Modulation of caveolin-1 expression can affect signalling through the Phosphatidylinositol 3–kinase/Akt pathway and cellular proliferation in response to insulin-like …
- Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through Phosphatidylinositol 3–kinase/AP-1-dependent …
- Role of c-KIT expression level and Phosphatidylinositol 3–kinase activation in survival and proliferative responses of early myeloid cells
- Role of Phosphatidylinositol 3–kinase/AKT as a survival pathway against CYP2E1-dependent toxicity
- Insulin causes renal dopamine D1 receptor desensitization via GRK2-mediated receptor phosphorylation involving Phosphatidylinositol 3–kinase and protein kinase C
- CAL-101, a Selective Inhibitor of the p110δ Isoform of Phosphatidylinositol 3–kinase, Effectively Induces Apoptosis in Primary Chronic Lymphocytic Leukemia …
- Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing Phosphatidylinositol 3–kinase and extracellular signal-regulated …
- Tannin 1‐α‐O‐galloylpunicalagin induces the calcium‐dependent activation of endothelial nitric‐oxide synthase via the Phosphatidylinositol 3‐kinase/Akt pathway in …
- … hepatocyte growth factor-induced invasion by preventing the association of adapter protein Gab1 and Phosphatidylinositol 3–kinase in melanoma cells
- Role of Phosphatidylinositol‐3‐kinase‐γ (PI3Kγ)‐mediated pathway in 17β‐estradiol‐induced killing of L. mexicana in macrophages from C57BL/6 mice
- … bovine preimplantation embryos with insulin‐like growth factor‐i prevents heat shock‐induced apoptosis through activation of the Phosphatidylinositol 3‐kinase/Akt …
- Constitutive activation of Phosphatidylinositol 3–kinase signaling pathway down-regulates TLR4-mediated tumor necrosis factor-α release in alveolar …
- LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of Phosphatidylinositol 3–kinase-Akt pathway
- … oxidative stress causes PC-12 cell apoptosis by both endoplasmic reticulum stress and mitochondrial intrinsic pathway: inhibition of Phosphatidylinositol 3–kinase …
- Differential involvement of Phosphatidylinositol 3‐kinase‐related protein kinases in hyperphosphorylation of replication protein A2 in response to replication‐mediated …
- Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a Phosphatidylinositol 3–kinase–independent pathway
- … translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and Phosphatidylinositol 3–kinase in human neutrophils
- H‐2g, a glucose analog of blood group H antigen, mediates mononuclear cell recruitment via Src and Phosphatidylinositol 3‐kinase pathways
- Hyperinsulinaemia increases the gene expression of endothelial nitric oxide synthase and the Phosphatidylinositol 3‐kinase/akt pathway in rat aorta
- Cell detachment modulates TRAIL resistance in ovarian cancer cells by downregulating the Phosphatidylinositol 3–kinase/Akt pathway
- Role of Phosphatidylinositol–3 kinase-γ in the actions of glucagon-like peptide-2 on the murine small intestine
- Angiopoietin 1 directly induces destruction of the rheumatoid joint by cooperative, but independent, signaling via ERK/MAPK and Phosphatidylinositol 3‐kinase/Akt
- Insulin and insulin-like growth factor-1 promote mast cell survival via activation of the Phosphatidylinositol–3–kinase pathway
- … /3′, 5′-cyclic adenosine monophosphate (cAMP) signaling, possibly through a Janus kinase 2-Phosphatidylinositol 3–kinase/Akt-phosphodiesterase 3-cAMP …
- … Estrogen Receptor Modulator, Inhibits Lipopolysaccharide-induced Nitric Oxide Production by Inhibiting the Phosphatidylinositol 3–kinase/Akt/Nuclear Factorkappa B …
- … acid stimulation of the sodium/iodide symporter in MCF-7 breast cancer cells is meditated by the insulin growth factor-I/Phosphatidylinositol 3–kinase and p38 mitogen …
- Haloperidol induces the nuclear translocation of Phosphatidylinositol 3′-kinase to disrupt Akt phosphorylation in PC12 cells
- Activation of MUC1 mucin expression by bile acids in human esophageal adenocarcinomatous cells and tissues is mediated by the Phosphatidylinositol 3–kinase
- Metformin improves atypical protein kinase C activation by insulin and Phosphatidylinositol–3, 4, 5-(PO4) 3 in muscle of diabetic subjects
- … to tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in oral squamous cell carcinoma cells treated with Phosphatidylinositol 3–kinase …
- CD86 stimulation on a B cell activates the Phosphatidylinositol 3–kinase/Akt and phospholipase Cγ2/protein kinase Cαβ signaling pathways
- Involvement of Phosphatidylinositol 3–kinase and extracellular-regulated kinase in hepatic stellate cell antioxidant response and myofibroblastic transdifferentiation
- Membrane electrical activity elicits inositol 1, 4, 5-trisphosphate-dependent slow Ca2+ signals through a Gβγ/Phosphatidylinositol 3–kinase γ pathway in …
- Nerve Growth Factor Inhibits Na+/H+ Exchange and HCO 3-Absorption through Parallel Phosphatidylinositol 3–kinase-mTOR and ERK Pathways in Thick …
- Electrical signals control wound healing through Phosphatidylinositol–3-OH kinase-γ and PTEN
- … antigen 1 by LFA878 induces apoptosis in multiple myeloma cells and is associated with downregulation of the focal adhesion kinase/Phosphatidylinositol 3 kinase …
- Phosphatidylinositol 3 kinase activation and AMPA receptor subunit trafficking underlie the potentiation of miniature EPSC amplitudes triggered by the activation of L …
- Glucose and insulin synergistically activate Phosphatidylinositol 3–kinase to trigger oscillations of Phosphatidylinositol 3, 4, 5-trisphosphate in beta-cells
- … factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and Phosphatidylinositol–3 kinase …
- Phosphatidylinositol‐3‐kinase inhibitor LY 294002 blocks Streptococcus mutans‐induced interleukin (IL)‐6 and IL‐8 gene expression in odontoblast‐like cells
- Control of neurite outgrowth and growth cone motility by Phosphatidylinositol‐3‐kinase
- Phase II enzyme induction by α-lipoic acid through Phosphatidylinositol 3–kinase-dependent C/EBPs activation
- Phospholipase A2–Modified Low-Density Lipoprotein Activates the Phosphatidylinositol 3–kinase-Akt Pathway and Increases Cell Survival in Monocytic Cells
- Activation of Phosphatidylinositol 3–kinase/Akt limits FGF-2-induced VEGF release in osteoblasts
- Inhibition of Phosphatidylinositol 3–kinase causes cell death in rat osteoblasts through inactivation of Akt
- Phosphatidylinositol 3–kinase p85α regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population
- Effects of the Phosphatidylinositol 3–kinase inhibitor in a mouse model of retinal neovascularization
- Ras transformation of RIE-1 cells activates cap-independent translation of ornithine decarboxylase: regulation by the Raf/MEK/ERK and Phosphatidylinositol 3–kinase …
- Inhibition of Phosphatidylinositol 3–kinase stimulates activity of the small-conductance K channel in the CCD
- Insulin activates ATP-sensitive potassium channels via Phosphatidylinositol 3–kinase in cultured vascular smooth muscle cells
- Macrophage paraoxonase 2 (PON2) expression is upregulated by unesterified cholesterol through activation of the Phosphatidylinositol 3–kinase (PI3K) pathway
- Inhibition of transforming growth factor-β/Smad signaling by Phosphatidylinositol 3–kinase pathway
- Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase and NF-κB involved in epidermal growth factor-induced matrix metalloproteinase-9 expression
- … derivative, inhibits cell proliferation and cell cycle progression via the cell cycle-related proteins by regulating Phosphatidylinositol–3 kinase cascade in vascular …
- Phosphatidylinositol 3–kinase/Akt signaling mediates interleukin-6 protection against p53-induced apoptosis in M1 myeloid leukemic cells
- … cannabinoid type 1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the Phosphatidylinositol 3–kinase pathway
- Nitric oxide protects mast cells from activation‐induced cell death: the role of the Phosphatidylinositol‐3 kinase‐Akt‐endothelial nitric oxide synthase pathway
- … differentiation in response to calcitriol for expression CD11b and CD14 is regulated by myeloid zinc finger‐1 protein downstream of Phosphatidylinositol 3‐kinase
- The involvement of Phosphatidylinositol 3–kinase in gonadotropin-releasing hormone-induced gonadotropin α-and FSHβ-subunit genes expression in clonal …
- Differential regulation of interleukin-12 and tumour necrosis factor-α by Phosphatidylinositol 3–kinase and ERK 1/2 pathways during Mycobacterium tuberculosis …
- Recruitment of the tyrosine phosphatase Src homology 2 domain tyrosine phosphatase-2 to the p85 subunit of Phosphatidylinositol–3 (PI-3) kinase is required for …
- The smaller isoforms of ankyrin 3 bind to the p85 subunit of Phosphatidylinositol 3′-kinase and enhance platelet-derived growth factor receptor down …
- Phosphatidylinositol–3 kinase/Akt/p70S6K/AP-1 signaling pathway mediated benzo (a) pyrene-induced cell cycle alternation via cell cycle regulatory proteins in …
- Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a Phosphatidylinositol 3–kinase-dependent fashion
- Phosphatidylinositol 3‐kinase/Akt auto‐regulates PDGF‐BB‐stimulated interleukin‐6 synthesis in osteoblasts
- Type 2 diabetes impairs insulin receptor substrate-2-mediated Phosphatidylinositol 3–kinase activity in primary macrophages to induce a state of cytokine resistance to …
- Phosphatidylinositol–3–kinase regulates mast cell ion channel activity
- Regulation of RalA GTPase by Phosphatidylinositol 3–kinase as visualized by FRET probes
- Expression and clinical significance of Phosphatidylinositol 3–kinase and protein kinase B in cervical carcinoma
- Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and Phosphatidylinositol 3–kinase …
- Thrombin induces osteoprotegerin synthesis via Phosphatidylinositol 3′‐kinase/mammalian target of rapamycin pathway in human periodontal ligament cells
- Phosphatidylinositol 3–kinase in the G Protein-Coupled Receptor–Induced Chemokinesis and Chemotaxis of MDA-MB-468 Breast Carcinoma Cells: A Comparison …
- Induction of Monocyte Chemotactic Protein 1 in Colonic Epithelial Cells by Entamoeba histolytica Is Mediated via the Phosphatidylinositol 3–kinase/p65 Pathway
- The release of fibroblast growth factor-1 from melanoma cells requires copper ions and is mediated by Phosphatidylinositol 3–kinase/Akt intracellular signaling …
- Simultaneous blockade of AP-1 and Phosphatidylinositol 3–kinase pathway in non-small cell lung cancer cells
- Triiodothyronine utilizes Phosphatidylinositol 3–kinase pathway to activate anti-apoptotic myeloid cell leukemia-1
- Distinct modes of activation of Phosphatidylinositol 3–kinase in response to cyclic adenosine 3′, 5′-monophosphate or insulin-like growth factor I play different roles …
- Proline 326 in the C terminus of murine CX3CR1 prevents G-protein and Phosphatidylinositol 3–kinase-dependent stimulation of Akt and extracellular signal-regulated …
- … in gastric ulcer healing: promotes actin polymerization, cell proliferation, re-epithelialization, and induces cyclooxygenase-2 in a Phosphatidylinositol 3–kinase …
- … prevents TGF-β-induced damage of the plasma membrane in cerebellar granule neurons by suppressing activation of p38-MAPK via the Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3–kinase-dependent insulin regulation of long-chain fatty acid (LCFA) metabolism in L6 muscle cells: involvement of atypical protein kinase …
- Phosphatidylinositol 3–kinase/Akt plays a part in tumor necrosis factor-α-induced interleukin-6 synthesis in osteoblasts
- … α‐mediated human polymeric immunoglobulin receptor expression is regulated by both mitogen‐activated protein kinase and Phosphatidylinositol‐3‐kinase in HT‐29 …
- … the 12-lipoxygenase gene expression and promotes cell proliferation in human keratinocytes via the extracellular regulatory kinase and Phosphatidylinositol 3–kinase …
- AMF/PGI transactivates the MMP-3 gene through the activation of Src-RhoA-Phosphatidylinositol 3–kinase signaling to induce hepatoma cell migration
- Phosphatidylinositol 3–kinase improves the efficiency of positive selection
- Sustained B7/CD28 interactions and resultant Phosphatidylinositol 3‐kinase activity maintain G1→S phase transitions at an optimal rate
- Ischemia-related changes of glial-derived neurotrophic factor and Phosphatidylinositol 3–kinase in the hippocampus: Their possible correlation in astrocytes
- Inhibitors of Phosphatidylinositol 3–kinase activity prevent cell cycle progression and induce apoptosis at the M/G1 transition in CHO cells
- Phosphatidylinositol 3–kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion
- Stimulation of interferon-β gene expression by human cytomegalovirus via nuclear factor kappa B and Phosphatidylinositol 3–kinase pathway
- Insulin-like growth factor-1 delays Fas-mediated apoptosis in human neutrophils through the Phosphatidylinositol–3 kinase pathway
- … 3 modulates barrier properties of human glomerular endothelial cells through a possible signaling pathway involving Phosphatidylinositol‐3 kinase/protein kinase B …
- Two specific inhibitors of the Phosphatidylinositol 3–kinase LY294002 and wortmannin up-regulate β1, 4-galactosyltransferase I and thus sensitize SMMC-7721 …
- Modulation of dendritic cell differentiation by colony‐stimulating factor‐1: role of Phosphatidylinositol 3′‐kinase and delayed caspase activation
- Protease-activated receptor-2 simultaneously directs β-arrestin-1-dependent inhibition and Gαq-dependent activation of Phosphatidylinositol 3–kinase
- Enhancement of susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells by Phosphatidylinositol 3–kinase inhibitor
- Peripubertal hyperinsulinemia upregulates Phosphatidylinositol 3–kinase/Akt pathway in rat ovaries
- Additive effects of PI3–kinase and MAPK activities on NB4 cell granulocyte differentiation: potential role of Phosphatidylinositol 3–kinase γ
- Erythropoietin enhances the therapy potency of autologous bone marrow stromal cells in a rat heart infarction model via Phosphatidylinositol–3–kinase/Akt pathway
- The Effect of Estradiol on in Vivo Tumorigenesis Is Modulated by the Human Epidermal Growth Factor Receptor 2/Phosphatidylinositol 3–kinase/Akt1 Pathway
- Two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via Phosphatidylinositol 3–kinase in response to fibroblast growth factor …
- … morphogenetic protein-2-induced osteogenic differentiation of rat spinal ligament cells via extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase
- Detection and significance of Phosphatidylinositol 3–kinase in adipose tissue of polycystic ovary syndrome patients with insulin resistance
- E-cadherin increases squamous cell carcinoma antigen expression through Phosphatidylinositol–3 kinase-Akt pathway in squamous cell carcinoma cell lines
- Dietary salt activates an endothelial proline-rich tyrosine kinase 2/c-Src/Phosphatidylinositol 3–kinase complex to promote endothelial nitric oxide synthase …
- Drug-resistant Phosphatidylinositol 3–kinase: guidance for the preemptive strike
- Sphingosine kinase, Phosphatidylinositol 3–kinase, Akt, NF-κB, and p300 are required for CCL5 production in Mycobacterium bovis Bacillus Calmette–Guérin (BCG) …
- Specific inhibition of basal mitogen-activated protein kinases and Phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the …
- … kinase A-independent cAMP stimulation of progesterone in a luteal cell model is tyrosine kinase dependent but Phosphatidylinositol–3–kinase and mitogen-activated …
- Functional role of Phosphatidylinositol 3–kinase/Akt pathway on cell growth and lytic cycle of Epstein–Barr virus in the Burkitt’s lymphoma cell line, P3HR-1
- Defective Phosphatidylinositol 3–kinase signaling in central control of cardiovascular effects in the nucleus tractus solitarii of spontaneously hypertensive rats
- 1α,25‐Dihydroxycholecalciferol activates binding of CREB to a CRE site in the CD14 promoter and drives promoter activity in a Phosphatidylinositol‐3 kinase …
- LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a Phosphatidylinositol 3 kinase-independent mechanism
- Schizosaccharomyces pombe Sst4p, a Conserved Vps27/Hrs Homolog, Functions Downstream of Phosphatidylinositol 3–kinase Pik3p To Mediate Proper Spore …
- Phosphatidylinositol 3–kinase/nuclear factor-κB signaling pathway is involved in the regulation of IGF-I on Fas-associated death domain-like interleukin-1 …
- Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 Phosphatidylinositol 3–kinase in human colonic tumour cells
- Identification and characterization of the catalytic subunit of Phosphatidylinositol 3–kinase in the yellow fever mosquito Aedes aegypti
- The Phosphatidylinositol 3–kinase-mediated production of interferon-β is critical for the lipopolysaccharide inhibition of osteoclastogenesis
- … a multimeric signaling complex involving grb-2-associated binder 2 (gab2), SRC homology phosphatase-2, and Phosphatidylinositol 3–kinase: evidence that negative …
- … Increases the Activity of Rat Excitatory Amino Acid Transporter Type 4 Expressed in Xenopus Oocytes: Role of Protein kinase C and Phosphatidylinositol 3‐kinase
- Rotenone-induced neurotoxicity of THP-1 cells requires production of reactive oxygen species and activation of Phosphatidylinositol 3–kinase
- Possible involvement of Phosphatidylinositol 3–kinase, but not protein kinase B or glycogen synthase kinase 3β, in progesterone-induced oocyte maturation in the …
- Phospholipase C, Phosphatidylinositol 3–kinase, and intracellular [Ca2+] mediate the activation of chicken HD11 macrophage cells by CpG oligodeoxynucleotide
- The Phosphatidylinositol 3 kinase pathway regulates tolerance to lipopolysaccharide and priming responses to Staphylococcus aureus and lipopolysaccharide
- … prevents oxidized low-density lipoprotein-induced injury of renal tubular epithelial cells by inhibiting the Phosphatidylinositol 3–kinase/Akt-signaling pathway.
- “PIKing” the Winner for Phosphatidylinositol 3–kinase Inhibitors in ErbB2-Positive Breast Cancer: Let’s Not “PTENed” It’s Easy!
- Phosphatidylinositol–3-phosphate kinase pathway activation protects leukemic large granular lymphocytes from undergoing homeostatic apoptosis
- The Phosphatidylinositol 3–kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake
- Platelet-derived growth factor-BB amplifies PGF2α-stimulated VEGF synthesis in osteoblasts: Function of Phosphatidylinositol 3–kinase
- Expression of mitogen-actived protein kinase, Phosphatidylinositol 3–kinase and hypoxia-inducible factor-1alpha in pulmonary arteries of patients with chronic …
- Fab1 Phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors
- Expression of Phosphatidylinositol–3 kinase in epithelial ovarian carcinoma
- Phosphatidylinositol 3–kinase/mammalian target of rapamycin pathway is critical for survival and proliferation of pancreatic cancer stem-like side population cells
- Effects of Huanglian Jiedu Decoction on Phosphatidylinositol–3–kinase expression in target tissues of type 2 diabetic rats
- Stem cell factor (SCF)-kit mediated Phosphatidylinositol 3 (PI3) kinase signaling during mammalian oocyte growth and early follicular development
- Febrile temperatures control antineutrophil cytoplasmic autoantibody–induced neutrophil activation via inhibition of Phosphatidylinositol 3‐kinase/Akt
- Recent patents of gene sequences relative to the Phosphatidylinositol 3–kinase/Akt pathway and their relevance to drug discovery
- … cell‐cycle progression in Xenopus oocytes independent of direct Grb2 and Shc binding or mos synthesis, but requires Phosphatidylinositol 3‐kinase and raf signaling
- Pleiotropic Effects of Phosphatidylinositol 3‐kinase in Monocyte Cell Regulation
- Phosphatidylinositol–3-OH kinase or RAS pathway mutations in human breast cancer cell lines
- Phosphatidylinositol–3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
- Up-regulation of gonadotropin alpha-subunit gene by Phosphatidylinositol 3–kinase inhibitors in clonal gonadotroph cells.
- SH3 domain of the Phosphatidylinositol 3–kinase regulatory subunit is responsible for the formation of a sequestration complex with insulin receptor substrate-1
- Inhibition of Phosphatidylinositol 3–kinase (PI3K) signalling leads to resistance to chemotherapeutic agents in human cancer cells
- Expression of Phosphatidylinositol 3–kinase and effects of wortmannin on the expression of tumor necrosis factor-alpha in ulcerative colitis
- Nongenomic activation of Phosphatidylinositol 3–kinase by thyroid hormone
- Overexpression of the p85α regulatory subunit of Phosphatidylinositol 3–kinase inhibits GM-CSF-dependent colony formation of CD34+ hematopoietic progenitor cells
- Phosphatidylinositol 3–kinase is a positive regulator of gibberellin signaling
- Calcium-induced Human Keratinocytes (HaCaT) Differentiation Requires Protein kinase B Activation in Phosphatidylinositol 3–kinase-dependent Manner
- SF1126, a novel integrin-targeting Phosphatidylinositol–3 kinase inhibitor, has radiosensitizing and anti-tumor effects in glioma model systems
- Exogenous application of persephin influences Phosphatidylinositol–3 kinase and MAPK/ERK signalling and enhances proliferation during early development in …
- Study on crosstalk between Phosphatidylinositol 3–kinase/Akt pathway and p38 mitogen-activated protein kinase pathway in cardiomyocyte with challenge of burn …
- TIMP-3 and Phosphatidylinositol 3–kinase genes were found to be related to the progression of colon cancer in a comparison of pneumoperitoneum and laparotomy in …
- Investigating the function of class I Phosphatidylinositol 3–kinase isoforms in glioma cell lines by siRNA-mediated depletion
- Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by Phosphatidylinositol 3, 5-bisphosphate
- Deregulation of the Phosphatidylinositol 3–kinase pathway in the airway epithelium of smokers is associated with lung cancer
- local shRNA modulation of Phosphatidylinositol 3–kinase signaling pathway reduces intimal hyperplasia in vein grafts: experiment with rats
- PI-103, a Dual Inhibitor of Class IA Phosphatidylinositol 3–kinase and Mammalian Target of Rapamycin, Has Cytotoxic Activity in T-Cell Acute Lymphoblastic …
- Dual regulation of glucocorticoid-induced leucine zipper (GILZ) by the glucocorticoid receptor and Phosphatidylinositol 3–kinase/AKT pathways in multiple myeloma
- The Involvement of Phosphatidylinositol–3 kinase signaling in
- Carvedilol Sensitizes Beta1- And Beta2-Adrenergic Receptors In Human Myocardium By Inhbiting A Phosphatidylinositol–3 kinase– And Phosphodiesterase 4 …
- All-Trans Retinoic Acid Accelerates Migration of MOLT3 to SDF-1 α/CXCL12 through the Phosphatidylinositol 3 kinase (PI3K)/Akt Pathway.
- Cardioprotection induced by olprinone, a phosphodiesterase III inhibitor, involves Phosphatidylinositol–3-OH kinase-Akt and a mitochondrial permeability transition …
- Illuminating the Phosphatidylinositol 3–kinase/Akt pathway
- Resveratrol regulates Bcl-2 family members, Phosphatidylinositol 3‘-kinase/AKT, mitochondrial p53 and apoptosis in prostate cancer cells.
- Variation in the regulatory subunit p85alpha of Phosphatidylinositol 3–kinase, PIK3R1, is associated with common forms of stroke
- Structure/Function Analysis of the Phosphatidylinositol–3–kinase Domain of Yeast Tral.
- Assortment of Phosphatidylinositol 3–kinase complexes–Atg14p directs association of complex I
- Phosphatidylinositol 3–kinase/Akt signaling pathway and angiogenesis
- Study of nuclear targets of Phosphatidylinositol–3 kinase in lymphocytes
- Phosphatidylinositol 3–kinase: a potential therapeutic target in oxidative stress and platelet aggregation
- Phosphatidylinositol 3–kinase Mediates Bronchioalveolar Stem Cell Expansion in Mouse
- Understanding Phosphatidylinositol 3–kinase independent survival pathways in the prostate cancer model, LNCaP
- Inhibition of Phosphatidylinositol 3‘–kinase/akt Signalling Does Not Affect Retinal Light–Susceptibility
- Protein kinase C and Phosphatidylinositol 3 kinase involved in the mechanism of myocardial remodeling in patients with congestive heart failure
- The investigation of Phosphatidylinositol 3–kinase (PI3K) isoforms which express by human prostate cancer cell lines, PC3 and DU145
- Phosphatidylinositol 3–kinase and Xanthine
- The role of the Phosphatidylinositol–3 kinase-AKT pathway in determining radiation sensitivity in the breast cancer cell line MDA-MB 231.
- Nongenomic activation of Phosphatidylinositol 3–kinase signaling by thyroid hormone receptors
- Association between Phosphatidylinositol 3–kinase Regulatory Subunit p85A Met326Ile Genetic Polymorphism and Colon Cancer Risk
- Differential induction of adoptosis during simulated ischaemia and hypoxia in myotubes: the role of the Phosphatidylinositol 3–kinase (PI3-K) signalling pathway
- Angelica Polysaccharides Promotes Thrombopoiesis through the Phosphatidylinositol 3–kinase/Akt Pathway.
- Inhibition of Phosphatidylinositol 3–kinase (PI3K) Improves Contractility in α-Adrenergic Stimulated Myocardium
- The Role of the Phosphatidylinositol–3 kinase-Akt-Glycogen Synthase kinase 3P Pathway in Protection from Myocardial Ischemia/Reperfusion Injury
- H11 kinase Promotes Cardiac Cell Growth and Survival Through an mTOR-Mediated Activation of the Phosphatidylinositol–3–kinase Pathway
- Effect of Phosphatidylinositol 3–kinase inhibition on estradiol-induced proliferation and hyperplasia formation in the mouse uterus
- Insulin activates nuclear phospholipase C independently of Phosphatidylinositol 3–kinase/Akt in HL-60 cells
- Phosphatidylinositol 3–kinase/AKT pathway is involved in retinoic acid-induced neuroblastoma cell differentiation
- Abnormal signaling activity of Phosphatidylinositol 3–kinase pathway in peripheral blood T cells from patients with systemic lupus erythematosus
- Phosphatidylinositol 3–kinase Regulates the Inflammatory Response of Macrophages to dsRNA and Encephalomyocarditis Virus.
- Role of Phosphatidylinositol 3–kinase in murine duodenal ion transport and bicarbonate secretion
- Electrical signals control wound healing via Phosphatidylinositol–3 kinase γ and PTEN
- Supplemental Data Regulation of Class Switch Recombination and Plasma Cell Differentiation by Phosphatidylinositol 3–kinase Signaling
- Nerve Growth Factor Inhibits Na⁺/H⁺ Exchange and {f1} Absorption through Parallel Phosphatidylinositol 3–kinase-mTOR and ERK Pathways in Thick Ascending …
- Inhibition of the Phosphatidylinositol 3–kinase/AKT pathway using small molecule inhibitor (QLT0267) against ILK can be used to sensitize breast tumour cells to …
- Phosphatidylinositol 3–kinase regulates bombesin-induced angiogenesis and in vivo neuroblastoma growth
- Phospholipase D and Phosphatidylinositol 3‐kinase are Activated by Oxidative Stress in Central Nervous System.
- The p85α regulatory subunit of Phosphatidylinositol 3‐kinase critically modulates class switch DNA recombination
- Phosphatidylinositol 3–kinase stimulates the proliferation of bronchioalveolar stem cells in mouse models of oncogenic K-ras-induced lung cancer
- Acute simulated hypoxia and ischemia in cultured C2C12 myotubes: decreased Phosphatidylinositol 3–kinase (PI3K)/Akt activity and its consequences for cell survival
- Protein chip discovery of secreted proteins regulated by the Phosphatidylinositol 3–kinase pathway in ovarian cancer cell lines
- Regulation of platelet‐activating factor (PAF) receptor by p85α subunit of Phosphatidylinositol 3‐kinase (PI3K) in enterocytes
- Phosphatidylinositol 3–kinase and MYCN regulation of VEGF expression in neuroblastoma cells
- Role of Phosphatidylinositol 3 kinase (PI3‐kinase) in Regulation of Apical Membrane Expression of the Type IIa Sodium‐Phosphate Cotransporter (Npt2a)
- Model Organisms and Disease; Phosphatidylinositol–3–kinase/Akt and glycogen synthase kinase–3β-mediated neuroprotective action of (-)-epigallocatechin-3-gallate …
- … -dioctanoyl-PI induces cell death in the human leukemic monocyte lymphoma cell line U-937 by disruption of the Phosphatidylinositol 3–kinase (PI3K)/Akt pathway …
- Beclin-1-hVps34 Phosphatidylinositol 3–kinase complexes function in autophagic and endocytic pathways
- Erythropoietin-mediated protection against hypoxia/reoxygenation injury in human muscle is via Phosphatidylinositol–3–kinase and p42/44 kinase activation
- Inhibition of mammalian target of rapamycin (mTOR) induces Phosphatidylinositol 3 kinase-dependent and Mnk-mediated eIF4E phosphorylation
- Protein chip discovery of secreted proteins regulated by the Phosphatidylinositol 3–kinase pathway in ovarian cancer cell lines: M. Moscova, DJ Marsh, RC Baxter …
- Interferon-Induces Human Vascular Smooth Muscle Cell Proliferation and Intimal Expansion by Phosphatidylinositol 3–kinase–Dependent Mammalian Target of …
- 49: Phosphatidylinositol 3–kinase pathway regulates hypoxia-inducible factor-1 to protect from intestinal injury during necrotizing enterocolitis
- … polymeric immunoglobulin receptor (pIgR) expression is regulated by both mitogen activated protein kinase (MAPK) and Phosphatidylinositol 3–kinase (PI3K) in HT …
- 149 EFFECT OF GROWTH HORMONE ON EXPRESSION OF P85α AND Phosphatidylinositol 3–kinase ACTIVITY IN 3T3-L1 CELLS AND EPIDIDYMAL FAT …
- O-009: NOD2 activates NF-kB p65 serine phosphorylation through a Phosphatidylinositol 3–kinase dependant pathway
- Oncogenic ras predicts lack of response to PX-866, an inhibitor of the Phosphatidylinositol–3–kinase pathway in tumor xenograft models.
- Decreased L-Type Ca2+ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3–kinase Signaling.
- Regulation of Fibrocyte‐derived CXC Chemokine Receptor 4 (CXCR4) by Hypoxia and the Phosphatidylinositol 3‐kinase (PI‐3‐K)/Mammalian Target of Rapamycin …
- … : P-selectin Reversibly Phosphorylates Nafl/PSGL-1 Cytoplasmic Domain Complex and Dynamically Recruits Phosphatidylinositol–3 kinase for Cyclic Activation and …
- DNA-binding activity of NF-κB and phosphorylation of p65 are induced by N-acetylcysteine through Phosphatidylinositol (PI) 3–kinase
- Role of Focal Adhesion kinase and Phosphatidylinositol 3
- … between L-thyroxine and 3, 5, 3‘-triiodo-L-thyronine and requirement for proliferation of mitogen-activated protein kinase, but not Phosphatidylinositol 3–kinase.
- Phosphatidylinositol–3-phosphate kinase pathway activation protects
- Nucleocytoplasmic shuttling of the Golgi Phosphatidylinositol 4-kinase Pik1 is regulated by 14-3–3 proteins and coordinates Golgi function with cell growth
- Advances in development of Phosphatidylinositol 3–kinase inhibitors
- Phosphatidylinositol 3–kinase and antiestrogen resistance in breast cancer
- Phosphatidylinositol 3–kinase (PI3K) pathway activation in bladder cancer
- Genetic alterations in the Phosphatidylinositol–3 kinase/Akt pathway in thyroid cancer
- Targeting the Phosphatidylinositol 3‐kinase signaling pathway in breast cancer
- Mutations in the Phosphatidylinositol 3–kinase pathway: role in tumor progression and therapeutic implications in breast cancer
- Phosphatidylinositol 3–kinase: the oncoprotein
- Clinical development of Phosphatidylinositol 3–kinase inhibitors for cancer treatment
- Take your PIK: Phosphatidylinositol 3–kinase inhibitors race through the clinic and toward cancer therapy
- The Phosphatidylinositol 3–kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients
- Phosphatidylinositol 3–kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular …
- Spectrum of Phosphatidylinositol 3–kinase Pathway Gene Alterations in Bladder CancerPhosphatidylinositol 3–kinase Pathway in Bladder Cancer
- Direct positive regulation of PTEN by the p85 subunit of Phosphatidylinositol 3–kinase
- Phosphatidylinositol–3–kinase/Akt signaling pathway and kidney cancer, and the therapeutic potential of Phosphatidylinositol–3–kinase/Akt inhibitors
- Phosphatidylinositol 3–kinase signaling does not activate the wnt cascade
- Hyperactivation of Phosphatidylinositol–3 kinase promotes escape from hormone dependence in estrogen receptor–positive human breast cancer
- ZSTK474, a novel Phosphatidylinositol 3–kinase inhibitor identified using the JFCR39 drug discovery system
- In vivo antitumor activity of MEK and Phosphatidylinositol 3–kinase inhibitors in basal-like breast cancer models
- 3-phosphoinositide–dependent kinase 1 potentiates upstream lesions on the Phosphatidylinositol 3–kinase pathway in breast carcinoma
- Correlating Phosphatidylinositol 3–kinase Inhibitor Efficacy with Signaling Pathway Status: In silico and Biological Evaluations
- New Phosphatidylinositol 3–kinase inhibitors for cancer
- Hot-spot mutations in p110α of Phosphatidylinositol 3–kinase (PI3K): differential interactions with the regulatory subunit p85 and with RAS
- Antiangiogenic effect of ZSTK474, a novel Phosphatidylinositol 3–kinase inhibitor
- Phosphatidylinositol 3–kinase (PI3K) signaling via glycogen synthase kinase–3 (Gsk-3) regulates DNA methylation of imprinted loci
- Activation of Phosphatidylinositol 3–kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells
- Preclinical modeling of combined Phosphatidylinositol–3–kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer
- The role of Phosphatidylinositol 3–kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia
- Liver dysfunction and Phosphatidylinositol–3–kinase signalling in early sepsis: experimental studies in rodent models of peritonitis
- Identification of small molecule inhibitors of Phosphatidylinositol 3–kinase and autophagy
- Phosphatidylinositol–3–kinase as a therapeutic target in melanoma
- Requirement of Phosphatidylinositol (3, 4, 5) Trisphosphate in Phosphatidylinositol 3–kinase-Induced Oncogenic TransformationRequirement for PIP3
- Thymic development beyond β-selection requires Phosphatidylinositol 3–kinase activation by CXCR4
- Phosphatidylinositol 3–kinase pathway activation in breast cancer brain metastases
- Phosphatidylinositol–3–kinase and AKT1 mutations occur early in breast carcinoma
- Mutations in the Phosphatidylinositol–3–kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for …
- A Rap/Phosphatidylinositol 3–kinase pathway controls pseudopod formation
- A Phosphatidylinositol 3–kinase–Pax3 axis regulates Brn-2 expression in melanoma
- Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the Phosphatidylinositol 3–kinase pathway
- Targeting Phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs
- Vertical targeting of the Phosphatidylinositol–3 kinase pathway as a strategy for treating melanoma
- BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the Phosphatidylinositol 3–kinase (PI3K)/Akt pathway
- Curcumin modulates nuclear factor κB (nf-κB)-mediated inflammation in human tenocytes in vitro: role of the Phosphatidylinositol 3–kinase/Akt pathway
- The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to Phosphatidylinositol 3–kinase inhibition
- Noninvasive Detection of Target Modulation following Phosphatidylinositol 3–kinase Inhibition Using Hyperpolarized 13C Magnetic Resonance Spectroscopy
- Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3′ kinase Inhibitor GDC-0941 in Breast Cancer Preclinical ModelsPI3K Inhibitor Biomarkers in Breast …
- Fractalkine‐induced activation of the Phosphatidylinositol‐3 kinase pathway attentuates microglial activation in vivo and in vitro
- The emerging role of the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis
- RGS16 inhibits breast cancer cell growth by mitigating Phosphatidylinositol 3–kinase signaling
- Molecular pharmacology of Phosphatidylinositol 3–kinase inhibition in human glioma
- Activation of Phosphatidylinositol–3′-kinase/AKT signaling is essential in hepatoblastoma survival
- Small-molecule inhibitors of Phosphatidylinositol 3–kinase/Akt signaling inhibit Wnt/β-catenin pathway cross-talk and suppress medulloblastoma growth
- Phosphatidylinositol–3–kinase/akt regulates bleomycin-induced fibroblast proliferation and collagen production
- Nanoparticle-mediated targeting of Phosphatidylinositol–3–kinase signaling inhibits angiogenesis
- Phosphatidylinositol 3–kinase isoforms as targets in respiratory disease
- Phosphatidylinositol 3–kinase-, actin-, and microtubule-dependent transport of Semliki Forest Virus replication complexes from the plasma membrane to modified …
- Helicobacter pylori Regulates Cellular Migration and Apoptosis by Activation of Phosphatidylinositol 3–kinase Signaling
- Inhibition of Phosphatidylinositol 3‐kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis
- Discovery of a potent, selective, and orally available class I Phosphatidylinositol 3–kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) …
- The survival pathways Phosphatidylinositol‐3 kinase (PI3‐K)/phosphoinositide‐dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through …
- Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral Phosphatidylinositol–3–kinase and mTOR inhibitor BGT226 in patients with advanced …
- Targeting the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin signaling network in cancer stem cells
- Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the Phosphatidylinositol 3–kinase (PI3K) signaling pathway
- Phosphatidylinositol 3–kinase inhibitor (LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo
- H1047R Phosphatidylinositol 3–kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3
- Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells: role of Phosphatidylinositol 3–kinase/akt pathway
- PfPI3K, a Phosphatidylinositol–3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking
- NVP-BEZ235, a novel dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
- The class IA Phosphatidylinositol 3–kinase p110-β subunit is a positive regulator of autophagy
- Vaspin protects vascular endothelial cells against free fatty acid-induced apoptosis through a Phosphatidylinositol 3–kinase/Akt pathway
- Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–Phosphatidylinositol–3–kinase complex
- Phosphatidylinositol‐3′‐kinase/AKT signaling is essential in synovial sarcoma
- Phosphatidylinositol 3–kinase isoforms as novel drug targets
- High glucose suppresses epidermal growth factor receptor/Phosphatidylinositol 3–kinase/Akt signaling pathway and attenuates corneal epithelial wound healing
- Macrophage differentiation and polarization via Phosphatidylinositol 3–kinase/Akt–ERK signaling pathway conferred by serum amyloid P component
- Inhibition profiles of Phosphatidylinositol 3–kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39
- Class IA Phosphatidylinositol 3–kinase in pancreatic β cells controls insulin secretion by multiple mechanisms
- O2 Regulates Skeletal Muscle Progenitor Differentiation through Phosphatidylinositol 3–kinase/AKT Signaling
- A Phosphatidylinositol 3–kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic
- A gene signature-based approach identifies thioridazine as an inhibitor of Phosphatidylinositol–3′-kinase (PI3K)/AKT pathway in ovarian cancer cells
- … lyase knockdown and statin treatment leads to dual blockade of mitogen‐activated protein kinase (MAPK) and Phosphatidylinositol‐3‐kinase (PI3K)/AKT pathways
- Phosphatidylinositol 3 kinase modulation of trophoblast cell differentiation
- Antimyeloma activity of the orally bioavailable dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor NVP-BEZ235
- Role and regulation of Phosphatidylinositol 3–kinase β in platelet integrin α2β1 signaling
- Phosphatidylinositol–3–kinase gamma plays a central role in blood–brain barrier dysfunction in acute experimental stroke
- The Phosphatidylinositol 3–kinase/akt cassette regulates purine nucleotide synthesis
- … object memory consolidation in middle-aged female mice requires dorsal hippocampal extracellular signal-regulated kinase and Phosphatidylinositol 3–kinase …
- Intracellular leptin-signaling pathways in hypothalamic neurons: the emerging role of Phosphatidylinositol–3 kinase-phosphodiesterase-3B-cAMP pathway
- Resveratrol inhibits LPS-induced MAPKs activation via activation of the Phosphatidylinositol 3–kinase pathway in murine RAW 264.7 macrophage cells
- TIPE2 controls innate immunity to RNA by targeting the Phosphatidylinositol 3–kinase–Rac pathway
- Two hits are better than one: targeting both Phosphatidylinositol 3–kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia …
- IL-10 inhibits the starvation induced autophagy in macrophages via class I Phosphatidylinositol 3–kinase (PI3K) pathway
- Effect of ZSTK474, a novel Phosphatidylinositol 3–kinase inhibitor, on DNA-dependent protein kinase
- Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of Phosphatidylinositol 3–kinase (PI3K)
- Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with α-lipoic acid through Phosphatidylinositol 3–kinase/Akt-dependent mechanism
- Synthesis and biological evaluation of novel analogues of the pan class I Phosphatidylinositol 3–kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4, 6-di (4-morpholinyl)-1 …
- CAL-101: a Phosphatidylinositol–3–kinase p110-delta inhibitor for the treatment of lymphoid malignancies
- Astragaloside IV stimulates angiogenesis and increases hypoxia-inducible factor-1α accumulation via Phosphatidylinositol 3–kinase/Akt pathway
- Phosphatidylinositol 3–kinase signaling in thymocytes: the need for stringent control
- Role of Phosphatidylinositol–3–kinase pathway in head and neck squamous cell carcinoma
- Knockdown of Ron kinase inhibits mutant Phosphatidylinositol 3–kinase and reduces metastasis in human colon carcinoma
- NF-κB and Phosphatidylinositol 3–kinase activity mediates the HCMV-induced atypical M1/M2 polarization of monocytes
- Genetic alterations in the RAS/RAF/mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase/Akt signaling pathways in the follicular variant of papillary …
- A Phosphatidylinositol 3–kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy
- … insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of Phosphatidylinositol 3–kinase-Akt and MEK-ERK …
- Phosphatidylinositol 3′-kinase Catalytic Subunit α Gene Amplification Contributes to the Pathogenesis of Mantle Cell LymphomaPIK3CA Gene Amplification in MCL
- Pooled analysis of Phosphatidylinositol 3–kinase pathway variants and risk of prostate cancer
- CAL-101, a p110δ selective Phosphatidylinositol–3–kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
- Inhibitors of Phosphatidylinositol–3–kinase in cancer therapy
- IKBKE protein activates Akt independent of Phosphatidylinositol 3–kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant …
- Foot-and-mouth disease virus induces autophagosomes during cell entry via a class III Phosphatidylinositol 3–kinase-independent pathway
- Mitogenic and anti-apoptotic effects of insulin in endometrial cancer are Phosphatidylinositol 3–kinase/Akt dependent
- Synthesis of Phosphatidylinositol 3–kinase (PI3K) inhibitory analogues of the sponge meroterpenoid liphagal
- mRNA degradation plays a significant role in the program of gene expression regulated by Phosphatidylinositol 3–kinase signaling
- Synergy between Phosphatidylinositol 3–kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung
- Changes related to Phosphatidylinositol 3–kinase/Akt signaling in leiomyomas: possible involvement of glycogen synthase kinase 3α and cyclin D2 in the …
- Synthesis and characterization of a novel prostate cancer-targeted Phosphatidylinositol–3–kinase inhibitor prodrug
- Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a Phosphatidylinositol 3–kinase/Akt-dependent mechanism in NSC34 motor …
- Spectrum of KIT/PDGFRA/BRAF mutations and Phosphatidylinositol–3–kinase pathway gene alterations in gastrointestinal stromal tumors (GIST)
- … -generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1α gene transcription via Phosphatidylinositol 3–kinase-Akt/protein kinase C …
- Nongenomic activation of Phosphatidylinositol 3–kinase signaling by thyroid hormone receptors
- Dual inhibition of Phosphatidylinositol 3‐kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid …
- Pharmacokinetic-pharmacodynamic modeling of tumor growth inhibition and biomarker modulation by the novel Phosphatidylinositol 3–kinase inhibitor GDC-0941
- Exercise training stimulates ischemia-induced neovascularization via Phosphatidylinositol 3–kinase/Akt-dependent hypoxia-induced factor-1α reactivation in mice of …
- Tanshinone IIA pretreatment protects myocardium against ischaemia/reperfusion injury through the Phosphatidylinositol 3‐kinase/Akt‐dependent pathway in diabetic …
- Relaxin improves TNF-α-induced endothelial dysfunction: the role of glucocorticoid receptor and Phosphatidylinositol 3–kinase signalling
- Multi-level targeting of the Phosphatidylinositol–3–kinase pathway in non-small cell lung cancer cells
- Participation of the Phosphatidylinositol 3–kinase/Akt pathway in Junin virus replication in vitro
- … ion irradiation suppresses metastatic potential of human non-small cell lung cancer A549 cells through the Phosphatidylinositol–3–kinase/Akt signaling pathway
- … Network Disruption by a Single Molecule Inhibitor Targeting Both Histone Deacetylase Activity and Phosphatidylinositol 3–kinase SignalingTargeting HDAC and PI3K …
- Resveratrol modulates interleukin-1β-induced Phosphatidylinositol 3–kinase and nuclear factor κB signaling pathways in human tenocytes
- Activity of the Novel Dual Phosphatidylinositol 3–kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic LeukemiaNVP …
- The p110δ isoform of Phosphatidylinositol 3–kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells
- Hydrogen sulfide and L-cysteine increase Phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin …
- Inhibition of autophagy as a strategy to augment radiosensitization by the dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor NVP-BEZ235
- … G1/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the Phosphatidylinositol 3–kinase/Akt pathway in …
- Isoflurane posttreatment reduces neonatal hypoxic–ischemic brain injury in rats by the sphingosine-1-phosphate/Phosphatidylinositol–3–kinase/Akt pathway
- Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via Phosphatidylinositol 3–kinase and Akt
- Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the Phosphatidylinositol 3–kinase pathway
- Alterations in the human epidermal growth factor receptor 2-Phosphatidylinositol 3–kinase-v-Akt pathway in gastric cancer
- A role for a CXCR2/Phosphatidylinositol 3–kinase γ signaling axis in acute and chronic vascular permeability
- Differential 14-3–3 affinity capture reveals new downstream targets of Phosphatidylinositol 3–kinase signaling
- The Class II Phosphatidylinositol 3 kinase C2β Is Required for the Activation of the K+ Channel KCa3.1 and CD4 T-Cells
- … induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and Phosphatidylinositol‐3‐kinase/protein kinase B pathways in …
- Cdc42 and the Phosphatidylinositol 3–kinase-Akt pathway are essential for PspC-mediated internalization of pneumococci by respiratory epithelial cells
- LRP1 regulates architecture of the vascular wall by controlling PDGFRβ-dependent Phosphatidylinositol 3–kinase activation
- Dual inhibition of class IA Phosphatidylinositol 3–kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia
- Phosphatidylinositol 3–kinase: a key regulator in adherens junction formation and function
- Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by Phosphatidylinositol–3 kinase signaling
- Blockade of Phosphatidylinositol 3–kinase (PI3K) δ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis
- Phosphatidylinositol 3–kinase plays a vital role in regulation of rice seed vigor via altering NADPH oxidase activity
- Forced, moderate-intensity treadmill exercise suppresses apoptosis by increasing the level of NGF and stimulating Phosphatidylinositol 3–kinase signaling in the …
- … to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by Phosphatidylinositol 3–kinase and extracellular signal …
- Ferulic acid protects human umbilical vein endothelial cells from radiation induced oxidative stress by Phosphatidylinositol 3–kinase and extracellular signal-regulated …
- Infection with Anaplasma phagocytophilum activates the Phosphatidylinositol 3–kinase/Akt and NF-κB survival pathways in neutrophil granulocytes
- Activation of Phosphatidylinositol 3–kinase is required for tumor necrosis factor-α-induced upregulation of matrix metalloproteinase-9: Its direct inhibition by quercetin
- Bis (morpholino-1, 3, 5-triazine) derivatives: potent adenosine 5′-triphosphate competitive Phosphatidylinositol–3–kinase/mammalian target of rapamycin inhibitors …
- Protein kinase C-δ and Phosphatidylinositol 3–kinase/Akt activate mammalian target of rapamycin to modulate NF-κB activation and intercellular adhesion …
- Phosphatidylinositol‐3‐kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig‐I to promote efficient type I interferon production
- E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/Phosphatidylinositol 3–kinase (akt/PI3K) signaling pathway
- Role for the Phosphatidylinositol 3–kinase-Akt-TOR pathway during sindbis virus replication in arthropods
- Plant Phosphatidylinositol 3–kinase
- … (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating Phosphatidylinositol 3–kinase (PI3K)/Akt-GSK …
- Phosphatidylinositol 3 kinase–Akt signaling serves as a circadian output in the retina
- NVP-BEZ235 and NVP-BGT226, dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell …
- Perfluorooctane sulfonate triggers tight junction “opening” in brain endothelial cells via Phosphatidylinositol 3–kinase
- Treadmill exercise suppresses muscle cell apoptosis by increasing nerve growth factor levels and stimulating p-Phosphatidylinositol 3–kinase activation in the soleus …
- … factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells in part through the inhibition of the Phosphatidylinositol 3–kinase/Akt …
- Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate Phosphatidylinositol 3–kinase (PI3K)
- … effect of guanosine against glutamate‐induced cell death in rat hippocampal slices is mediated by the Phosphatidylinositol‐3 kinase/Akt/glycogen synthase kinase 3β …
- Infectious bursal disease virus activates the Phosphatidylinositol 3–kinase (PI3K)/Akt signaling pathway by interaction of VP5 protein with the p85α subunit of …
- Role of the Phosphatidylinositol–3–kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target …
- Trpc1 ion channel modulates Phosphatidylinositol 3–kinase/Akt pathway during myoblast differentiation and muscle regeneration
- The Phosphatidylinositol 3–kinase/mTor pathway as a therapeutic target for brain aging and neurodegeneration
- Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III Phosphatidylinositol 3–kinase activity and tumor suppression
- The roles and mechanisms of PAR4 and P2Y12/Phosphatidylinositol 3‐kinase pathway in maintaining thrombin‐induced platelet aggregation
- Approaches and limitations of Phosphatidylinositol–3–kinase pathway activation status as a predictive biomarker in the clinical development of targeted therapy
- Inhibitory activity of flavonoids against class I Phosphatidylinositol 3–kinase isoforms
- cAMP activates TRPC6 channels via the Phosphatidylinositol 3–kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 …
- Alterations in Phosphatidylinositol 3–kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims
- Propranolol improves impaired hepatic Phosphatidylinositol 3–kinase/akt signaling after burn injury
- MAPK, Phosphatidylinositol 3–kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic …
- The emerging role of the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin signaling network in cancer stem cell biology
- Vascular endothelial growth factor receptor-3 directly interacts with Phosphatidylinositol 3–kinase to regulate lymphangiogenesis
- Effect of Phosphatidylinositol–3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz [a] anthracene in neonatal rat ovaries
- Phosphatidylinositol 3–kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain
- Requirement of the Phosphatidylinositol 3–kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of …
- Class IA Phosphatidylinositol 3–kinase signaling in non-small cell lung cancer
- Non-Smad transforming growth factor-β signaling regulated by focal adhesion kinase binding the p85 subunit of Phosphatidylinositol 3–kinase
- Phosphatidylinositol 3–kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice
- Phosphatidylinositol 3–kinase/AKT/mammalian target of rapamycin pathway inhibition: a breakthrough in the management of luminal (ER+/HER2−) breast cancers?
- Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and Phosphatidylinositol 3–kinase-dependent NF-κB activation
- Characterization and targeting of Phosphatidylinositol–3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer
- Activation of the Phosphatidylinositol 3–kinase/Akt signaling pathway during porcine circovirus type 2 infection facilitates cell survival and viral replication
- … Spinal Cord Ischemia–Reperfusion Injury Induced by Different Ischemic Postconditioning Methods: Roles of Phosphatidylinositol 3–kinase–Akt and Extracellular …
- … receptor α-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to ambient IGF, leading to Phosphatidylinositol 3–kinase/AKT-dependent Wnt …
- Phosphatidylinositol 3–kinase mediates pain behaviors induced by activation of peripheral ephrinBs/EphBs signaling in mice
- Strain-induced proliferation requires the Phosphatidylinositol 3–kinase/AKT/glycogen synthase kinase pathway
- Development and evaluation of PIK75 nanosuspension, a Phosphatidylinositol–3–kinase inhibitor
- L-Thyroxine vs. 3, 5, 3′-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase
- Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival Phosphatidylinositol 3–kinase/Akt pathway
- Gender-related difference of sevoflurane postconditioning in isolated rat hearts: focus on Phosphatidylinositol–3–kinase/Akt signaling
- Frat is a Phosphatidylinositol 3–kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells
- Phosphatidylinositol 3‐kinase‐δ up‐regulates L‐type Ca2+ currents and increases vascular contractility in a mouse model of type 1 diabetes
- PKI-179: an orally efficacious dual Phosphatidylinositol–3–kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor
- Insulin stabilizes microvascular endothelial barrier function via Phosphatidylinositol 3–kinase/Akt-mediated Rac1 activation
- Toll-Like Receptor 2- and MyD88-Dependent Phosphatidylinositol 3–kinase and Rac1 Activation Facilitates the Phagocytosis of Listeria monocytogenes by Murine …
- The Phosphatidylinositol 3–kinase-AKT-mammalian target of rapamycin signaling network and the control of normal myelopoiesis
- Clinical development of Phosphatidylinositol–3 kinase pathway inhibitors
- α7 Nicotinic receptor activation reduces β‐amyloid‐induced apoptosis by inhibiting caspase‐independent death through Phosphatidylinositol 3‐kinase signaling
- … patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the Phosphatidylinositol 3–kinase-AKT-mammalian target …
- Mesenchymal stem cells inhibition of chronic ethanol-induced oxidative damage via upregulation of Phosphatidylinositol–3–kinase/Akt and modulation of extracellular …
- Phosphatidylinositol 3′-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis
- Phosphatidylinositol 3–kinase facilitates microtubule-dependent membrane transport for neuronal growth cone guidance
- Phosphatidylinositol 3–kinase-Akt signaling in pulmonary carcinoid cells
- Phosphatidylinositol–3–kinase pathway mutations are common in breast columnar cell lesions
- Activation of Phosphatidylinositol 3–kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine …
- … cells is mediated by αvβ3 and β1 integrins through synergistic interactions of focal adhesion kinase and Shc with Phosphatidylinositol 3–kinase and the Akt …
- Collagen VI protects against neuronal apoptosis elicited by ultraviolet irradiation via an Akt/Phosphatidylinositol 3–kinase signaling pathway
- ZSTK474, a specific Phosphatidylinositol 3–kinase inhibitor, induces G1 arrest of the cell cycle in vivo
- A new dimension to Ras function: A novel role for nucleotide-free Ras in class II Phosphatidylinositol 3–kinase beta (PI3KC2β) regulation
- Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the Phosphatidylinositol 3–kinase signaling pathway in human colon cancer cells
- Hydrogen peroxide activates focal adhesion kinase and c-Src by a Phosphatidylinositol 3 kinase-dependent mechanism and promotes cell migration in Caco-2 cell …
- Phosphatidylinositol 3–kinase, a novel target molecule for the inhibitory effects of kaempferol on neoplastic cell transformation
- … receptor-independent action involving the consecutive activation of Gα13, c-Src, the insulin-like growth factor-I receptor, and Phosphatidylinositol 3–kinase/Akt
- Hepatitis B x-interacting protein induces HepG2 cell proliferation through activation of the Phosphatidylinositol 3–kinase/Akt pathway
- Phosphatidylinositol–3–kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells
- Phosphatidylinositol 3–kinase/Akt signaling pathway mediates acupuncture-induced dopaminergic neuron protection and motor function improvement in a mouse …
- Therapeutic targeting of the Phosphatidylinositol 3–kinase signaling pathway: novel targeted therapies and advances in the treatment of colorectal cancer
- t-DARPP regulates Phosphatidylinositol–3–kinase-dependent cell growth in breast cancer
- Inhibition of Phosphatidylinositol 3–kinase promotes tumor cell resistance to chemotherapeutic agents via a mechanism involving delay in cell cycle progression
- Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and Phosphatidylinositol 3 kinase
- RETRACTED: Implication of Phosphatidylinositol–3 kinase/Akt/glycogen synthase kinase–3β pathway in ginsenoside Rb1’s attenuation of beta-amyloid-induced …
- A Multicenter Phase I Trial of PX-866, an Oral Irreversible Phosphatidylinositol 3–kinase Inhibitor, in Patients with Advanced Solid TumorsFirst-in-Human Trial of PX …
- Interactome mapping of the Phosphatidylinositol 3–kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a …
- … )/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through Phosphatidylinositol 3–kinase γ and vesicle …
- Oncogene Ras/Phosphatidylinositol 3–kinase signaling targets histone H3 acetylation at lysine 56
- Novel Phosphatidylinositol 3–kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone
- Phosphatidylinositol 3 kinase pathway and 4-hydroxy-2-nonenal-induced oxidative injury in the RPE
- Activation of Phosphatidylinositol 3–kinase/akt and impairment of nuclear factor-κB: molecular mechanisms behind the arrested maturation/activation state of …
- Phosphatidylinositol 3–kinase γ inhibition ameliorates inflammation and tumor growth in a model of colitis-associated cancer
- Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and …
- Identification of focal adhesion kinase (FAK) and Phosphatidylinositol 3‐kinase (PI3‐kinase) as Par3 partners by proteomic analysis
- dl-3n-Butylphthalide promotes angiogenesis via the extracellular signal-regulated kinase 1/2 and Phosphatidylinositol 3–kinase/Akt-endothelial nitric oxide synthase …
- Maternal Phosphatidylinositol 3‐kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis
- Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of Phosphatidylinositol–3–kinase/Akt and endothelial nitric oxide …
- Mechanism of action of the suppression of influenza virus replication by Ko-Ken Tang through inhibition of the Phosphatidylinositol 3–kinase/Akt signaling pathway and …
- 14-3–3ζ binds class III Phosphatidylinositol–3–kinase and inhibits autophagy
- Epithelial Phosphatidylinositol–3–kinase signaling is required for β-catenin activation and host defense against Citrobacter rodentium infection
- Synthesis and SAR of novel 4-morpholinopyrrolopyrimidine derivatives as potent Phosphatidylinositol 3–kinase inhibitors
- … USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by Phosphatidylinositol 3–kinase/Akt/glycogen synthase …
- Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates Phosphatidylinositol 3–kinase/mitogen-activated protein …
- Disruption of Platelet-Derived Growth Factor–Dependent Phosphatidylinositol 3–kinase and Phospholipase Cγ 1 Activity Abolishes Vascular Smooth Muscle Cell …
- Class IA Phosphatidylinositol 3‐kinase regulates osteoclastic bone resorption through protein kinase B–mediated vesicle transport
- Radix Astragali extract promotes angiogenesis involving vascular endothelial growth factor receptor‐related Phosphatidylinositol 3‐kinase/Akt‐dependent pathway in …
- Integration of Phosphatidylinositol 3–kinase, Akt kinase, and Smad signaling pathway in BMP-2-induced osterix expression
- Effect of hydrogen sulfide on the Phosphatidylinositol 3–kinase-protein kinase B pathway and on caerulein-induced cytokine production in isolated mouse pancreatic …
- The Phosphatidylinositol 3–kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kappa B inhibition, in a PI3K …
- Ionizing radiation up-regulates telomerase activity in cancer cell lines by post-translational mechanism via ras/Phosphatidylinositol 3–kinase/Akt pathway
- Cinnamic acid, from the bark of Cinnamomum cassia, regulates glucose transport via activation of GLUT4 on L6 myotubes in a Phosphatidylinositol 3‐kinase …
- … protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the Phosphatidylinositol 3–kinase/Akt signaling pathway
- Curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-κB pathways through a crossed Phosphatidylinositol 3–kinase/Akt/IκB kinase complex …
- Phase I Study of Rigosertib, an Inhibitor of the Phosphatidylinositol 3–kinase and Polo-like kinase 1 Pathways, Combined with Gemcitabine in Patients with Solid …
- Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3–Phosphatidylinositol 3–kinase–akt pathway through its sex hormone-binding …
- cIAP2 Upregulated by E6 Oncoprotein via Epidermal Growth Factor Receptor/Phosphatidylinositol 3–kinase/AKT Pathway Confers Resistance to Cisplatin in Human …
- Antitumor Efficacy Profile of PKI-402, a Dual Phosphatidylinositol 3–kinase/Mammalian Target of Rapamycin InhibitorPKI-402, a Dual PI3K/mTOR Inhibitor
- Peptidoglycan enhances proinflammatory cytokine expression through the TLR2 receptor, MyD88, Phosphatidylinositol 3–kinase/AKT and NF-kappaB pathways in BV …
- Role of the Phosphatidylinositol 3–kinase/protein kinase B pathway in regulating alternative splicing of tissue factor mRNA in human endothelial cells
- FHL-2 suppresses VEGF-induced Phosphatidylinositol 3–kinase/Akt activation via interaction with sphingosine kinase-1
- … Growth and Metastatic Potential of MDA-MB-231 Breast Cancer Cells through Modulation of the Phosphatidylinositol 3–kinase PathwayChemopreventive Effects of …
- … Reverses the Declined Activity of Aged Rat–Derived Endothelial Progenitor Cells: Involvement of the Phosphatidylinositol 3–kinase/Akt Signaling Pathway
- Hybrid inhibitors of Phosphatidylinositol 3–kinase (PI3K) and the mammalian target of rapamycin (mTOR): design, synthesis, and superior antitumor activity of novel …
- Activation of the Phosphatidylinositol 3′-kinase/AKT pathway in neuroblastoma and its regulation by thioredoxin 1
- Phosphatidylinositol 3′-kinase signalling supports cell height in established epithelial monolayers
- PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a Phosphatidylinositol 3–kinase pathway
- Myeloid cell IL-10 production in response to leishmania involves inactivation of glycogen synthase kinase–3β downstream of Phosphatidylinositol–3 kinase
- IL-15 renders conventional lymphocytes resistant to suppressive functions of regulatory T cells through activation of the Phosphatidylinositol 3–kinase pathway
- Human CD34-derived myeloid dendritic cell development requires intact Phosphatidylinositol 3–kinase–protein kinase B–mammalian target of rapamycin signaling
- … and P2Y12 Receptor Agonists Are Not Chemoattractants and Macrophage Chemotaxis to Complement C5a Is Phosphatidylinositol 3–kinase (PI3K)-and p38 …
- Inhibition of the Phosphatidylinositol 3–kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency
- Cyclic Mechanical Stretch Decreases Cell Migration by Inhibiting Phosphatidylinositol 3–kinase-and Focal Adhesion kinase-mediated JNK1 Activation 2♦
- Calcium-and Phosphatidylinositol 3–kinase/Akt-dependent activation of endothelial nitric oxide synthase by apigenin
- Protein kinase A and protein kinase C (a)/PPP1CC2 play opposing roles in the regulation of Phosphatidylinositol 3–kinase activation in bovine sperm
- Cross talk between Phosphatidylinositol 3–kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/β-arrestin/cAMP …
- Regulation of Cdk7 activity through a Phosphatidylinositol (3)-kinase/PKC-ι-mediated signaling cascade in glioblastoma
- Chorionic gonadotropin regulates prostaglandin E synthase via a Phosphatidylinositol 3–kinase-extracellular regulatory kinase pathway in a human endometrial …
- Protein kinases A and C and Phosphatidylinositol 3 kinase regulate glycogen synthase kinase‐3A serine 21 phosphorylation in boar spermatozoa
- … Hormone-Related Protein Regulates Cell Survival Pathways via Integrin α6β4-Mediated Activation of Phosphatidylinositol 3–kinase/Akt SignalingPTHrP-Mediated …
- The role of the Phosphatidylinositol 3–kinase (PI3K) pathway in the development and treatment of uterine cancer
- Insulin-dependent Phosphatidylinositol 3–kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis
- Activation of Phosphatidylinositol 3–kinase/Akt signaling by EGF downregulates membranous E-cadherin and β-catenin and enhances invasion in nasopharyngeal …
- Electroacupuncture inhibits phosphorylation of spinal Phosphatidylinositol 3–kinase/Akt in a carrageenan-induced inflammatory rat model
- Preparation and evaluation of trisubstituted pyrimidines as Phosphatidylinositol 3–kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements
- Mechanisms involved in Phosphatidylinositol 3–kinase pathway mediated up-regulation of the mu opioid receptor in lymphocytes
- Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and Phosphatidylinositol 3–kinase
- Paraquat-induced oxidative stress represses Phosphatidylinositol 3–kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes
- CAL-101, an isoform-selective inhibitor of Phosphatidylinositol 3–kinase P110δ, demonstrates clinical activity and pharmacodynamic effects in patients with …
- Preclinical assessment of the absorption and disposition of the Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its …
- Inhibition of Phosphatidylinositol 3–kinase/Akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors
- The p110δ isoform of Phosphatidylinositol 3–kinase controls the quality of secondary anti-Leishmania immunity by regulating expansion and effector function of …
- … postconditioning is not restored by insulin in the rat heart: phosphorylated signal transducer and activator of transcription 3–and Phosphatidylinositol 3–kinase …
- … ‐conditioning protects both adult and aged Sprague‐Dawley rat heart from ischaemia–reperfusion injury through the Phosphatidylinositol 3‐kinase–akt and glycogen …
- The Phosphatidylinositol–3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats
- Phosphatidylinositol 3–kinase isoform-specific effects in airway mesenchymal cell function
- Synergistic effect of a combination of nanoparticulate Fe3O4 and gambogic acid on Phosphatidylinositol 3–kinase/Akt/Bad pathway of LOVO cells
- Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1-and Phosphatidylinositol 3–kinase-dependent mechanisms
- Phosphatidylinositol 3‐kinase interacts with the glucocorticoid receptor upon TLR2 activation
- Inhibitory effects of ZSTK474, a Phosphatidylinositol 3–kinase inhibitor, on adjuvant-induced arthritis in rats
- Phosphatidylinositol‐3 kinase activity in B cells is negatively regulated by Lyn tyrosine kinase
- Heat shock protein 90 regulates Phosphatidylinositol 3‐kinase‐related protein kinase family proteins together with the RUVBL1/2 and Tel2‐containing co‐factor …
- Vascular endothelial growth factor protects motoneurons from serum deprivation–induced cell death through Phosphatidylinositol 3–kinase-mediated p38 mitogen …
- Phosphatidylinositol 3–kinase inhibitor (PIK75) containing surface functionalized nanoemulsion for enhanced drug delivery, cytotoxicity and pro-apoptotic activity in …
- Dystrophin glycoprotein complex‐associated Gβγ subunits activate Phosphatidylinositol‐3‐kinase/Akt signaling in skeletal muscle in a laminin‐dependent manner
- Involvement of Phosphatidylinositol 3–kinase in cAMP-and cGMP-induced duodenal epithelial CFTR activation in mice
- Potential prognostic value of heat-shock protein 90 in the presence of Phosphatidylinositol–3–kinase overexpression or loss of PTEN, in invasive breast …
- Cilnidipine mediates a neuroprotective effect by scavenging free radicals and activating the Phosphatidylinositol 3‐kinase pathway
- Antioxidant c-FLIP inhibits Fas ligand-induced NF-κB activation in a Phosphatidylinositol 3–kinase/Akt-dependent manner
- TNFα up-regulates claudin-2 expression in epithelial HT-29/B6 cells via Phosphatidylinositol–3–kinase signaling
- A yeast-based in vivo bioassay to screen for class I Phosphatidylinositol 3–kinase specific inhibitors
- Phosphatidylinositol 3–kinase/AKT pathway regulates the endoplasmic reticulum to golgi traffic of ceramide in glioma cells: a link between lipid signaling …
- … (FK 228) and its analogs directly inhibit Phosphatidylinositol 3‐kinase activity and potently induce apoptosis as histone deacetylase/Phosphatidylinositol 3‐kinase …
- Angiotensin II-induced aortic ring constriction is mediated by Phosphatidylinositol 3–kinase/L-type calcium channel signaling pathway
- Lithium attenuates bupivacaine-induced neurotoxicity in vitro through Phosphatidylinositol–3–kinase/threonine-serine protein kinase B-and extracellular signal …
- Prostaglandin F2α represses IGF-I-stimulated IRS1/Phosphatidylinositol–3–kinase/AKT signaling in the corpus luteum: role of ERK and P70 ribosomal S6 kinase
- Establishment of Phosphatidylinositol 3‐kinase inhibitor‐resistant cancer cell lines and therapeutic strategies for overcoming the resistance
- Induction of steroid sulfatase expression by tumor necrosis factor-α through Phosphatidylinositol 3–kinase/Akt signaling pathway in PC-3 human prostate …
- A novel imidazopyridine analogue as a Phosphatidylinositol 3–kinase inhibitor against human breast cancer
- … -inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through Phosphatidylinositol 3–kinase–regulated mammalian target of …
- The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for Phosphatidylinositol 3–kinase and Cdc42
- Colony-stimulating factor-1–induced oscillations in Phosphatidylinositol–3 kinase/AKT are required for caspase activation in monocytes undergoing differentiation into …
- Adenomatous polyposis coli and Asef function downstream of hepatocyte growth factor and Phosphatidylinositol 3–kinase
- … D3 prevents puromycin aminonucleoside-induced apoptosis of glomerular podocytes by activating the Phosphatidylinositol 3–kinase/Akt-signaling pathway
- WAVE2, N‐WASP, and mena facilitate cell invasion via Phosphatidylinositol 3‐kinase‐dependent local accumulation of actin filaments
- Invasion of endothelial cells by tissue-invasive M3 type group A streptococci requires Src kinase and activation of Rac1 by a Phosphatidylinositol 3–kinase …
- … group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/Phosphatidylinositol 3–kinase γ …
- Inulin increases glucose transport in C2C12 myotubes and HepG2 cells via activation of AMP-activated protein kinase and Phosphatidylinositol 3–kinase pathways
- Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1/2 and Phosphatidylinositol–3–kinase/Akt/glycogen synthase …
- Discovery of Phosphatidylinositol 3–kinase inhibitory compounds from the Screening Committee of Anticancer Drugs (SCADS) library
- … peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of Phosphatidylinositol 3–kinase
- HS-116, a novel Phosphatidylinositol 3–kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K …
- … )-binding protein (Cbp)/PAG1 is mediated by epigenetic histone modifications via the mitogen-activated protein kinase (MAPK)/Phosphatidylinositol 3–kinase …
- Phosphatidylinositol 3–kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is …
- CAL-101, a Potent Selective Inhibitor of the p110δ Isoform of Phosphatidylinositol 3–kinase, Attenuates Pathway Signaling, Induces Apoptosis, and Overcomes …
- … endothelial growth factor-induced angiogenesis by inhibiting ras-dependent mitogen-activated protein kinase and Phosphatidylinositol 3–kinase/Akt signal pathways
- Nf1−/− Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of Phosphatidylinositol 3–kinase
- Interferon-α-induced mTOR activation is an anti-hepatitis C virus signal via the Phosphatidylinositol 3–kinase-Akt-independent pathway
- A phase 1 study of the selective Phosphatidylinositol 3–kinase-delta (PI3Kδ) inhibitor, CAL-101 (GS-1101), in combination with rituximab and/or bendamustine …
- Nitroglycerin drives endothelial nitric oxide synthase activation via the Phosphatidylinositol 3–kinase/protein kinase B pathway
- … by SP600125 of Fcε receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of Phosphatidylinositol 3–kinase …
- HIV-Mediated Phosphatidylinositol 3–kinase/Serine–Threonine kinase Activation in APCs Leads to Programmed Death-1 Ligand Upregulation and Suppression of …
- The diabetogenic effects of excessive ethanol: reducing β-cell mass, decreasing Phosphatidylinositol 3–kinase activity and GLUT-4 expression in rats
- Berberine induces heme oxygenase-1 up-regulation through Phosphatidylinositol 3–kinase/AKT and NF-E2-related factor-2 signaling pathway in astrocytes
- Phosphorylation of Phosphatidylinositol–3–kinase-protein kinase B and extracellular signal-regulated kinases 1/2 mediate reoxygenation-induced cardioprotection …
- Grape seed proanthocyanidins attenuate vascular smooth muscle cell proliferation via blocking Phosphatidylinositol 3‐kinase‐dependent signaling pathways
- Activation-induced degradation of FLIPL is mediated via the Phosphatidylinositol 3–kinase/Akt signaling pathway in macrophages
- The loss of Cbl-Phosphatidylinositol 3–kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival
- Phosphatidylinositol–3–kinase C2β and TRIM27 function to positively and negatively regulate IgE receptor activation of mast cells
- Phosphatidylinositol 3–kinase inhibitor LY294002 suppresses proliferation and sensitizes doxorubicin chemotherapy in bladder cancer cells
- Phosphatidylinositol 3–kinase-C2β inhibits cisplatin-mediated apoptosis via the Akt pathway in oesophageal squamous cell carcinoma
- 14-3–3: Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate Phosphatidylinositol 3–kinase activation and cell survival
- 4-Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells via Phosphatidylinositol–3–kinase-dependent pathway
- Inhibition of activated Phosphatidylinositol 3–kinase/AKT pathway in malignant pleural mesothelioma leads to G1 cell cycle arrest
- Efficacy of Phosphatidylinositol–3 kinase inhibitors in a primary mouse model of undifferentiated pleomorphic sarcoma
- Combinations of the selective Phosphatidylinositol 3–kinase-delta (PI3Kdelta) inhibitor GS–1101 (CAL-101) with rituximab and/or bendamustine are tolerable and …
- Electroconvulsive seizure-induced VEGF is correlated with neuroprotective effects against cerebral infarction: Involvement of the Phosphatidylinositol–3 kinase/Akt …
- Inhibitory actions of the Phosphatidylinositol 3‐kinase inhibitor LY294002 on the human Kv1. 5 channel
- Shift to an involvement of Phosphatidylinositol 3–kinase in angiotensin II actions on nucleus tractus solitarii neurons of the spontaneously hypertensive rat
- Hepatoma-derived growth factor stimulates podosome rosettes formation in NIH/3T3 cells through the activation of Phosphatidylinositol 3–kinase/Akt pathway
- Anti‐apoptotic effect of heat shock protein 90 on hypoxia‐mediated cardiomyocyte damage is mediated via the Phosphatidylinositol 3‐kinase/AKT pathway
- Proteasome inactivation promotes p38 mitogen-activated protein kinase-dependent Phosphatidylinositol 3–kinase activation and increases interleukin-8 production in …
- The Phosphatidylinositol 3–kinase/Akt pathway regulates transforming growth factor-β signaling by destabilizing ski and inducing Smad7
- Pharmacological preconditioning in type 2 diabetic rat hearts: the roles of mitochondrial ATP-sensitive potassium channels and the Phosphatidylinositol 3–kinase-Akt …
- Cyanidin suppresses neoplastic cell transformation by directly targeting Phosphatidylinositol 3–kinase
- Phase I study of CAL-101, an isoform-selective inhibitor of Phosphatidylinositol 3‐kinase P110d, in patients with previously treated chronic lymphocytic leukemia.
- Psoralidin, an Herbal Molecule, Inhibits Phosphatidylinositol 3–kinase–Mediated Akt Signaling in Androgen-Independent Prostate Cancer CellsPsoralidin Targets Akt …
- WJD008, a dual Phosphatidylinositol 3–kinase (PI3K)/mammalian target of rapamycin inhibitor, prevents PI3K signaling and inhibits the proliferation of transformed …
- … Conductance Regulator-dependent cAMP-stimulated Alveolar Epithelial Fluid Transport via a Phosphatidylinositol 3–kinase-dependent Mechanism 2
- … -interstitial nephritis antigen (TINag) in cell survival utilizing integrin αvβ3/focal adhesion kinase (FAK)/Phosphatidylinositol 3–kinase (PI3K)/protein kinase B …
- Transcriptional and post‐transcriptional control of DNA methyltransferase 3B is regulated by Phosphatidylinositol 3 kinase/Akt pathway in human hepatocellular …
- Aurora-A down-regulates IkappaBα via Akt activation and interacts with insulin-like growth factor-1 induced Phosphatidylinositol 3–kinase pathway for cancer …
- Phosphatidylinositol 3‐kinase/protein kinase Cδ activation induces close homolog of adhesion molecule L1 (CHL1) expression in cultured astrocytes
- Differential modulation of brainstem Phosphatidylinositol 3–kinase/Akt and extracellular signal-regulated kinase 1/2 signaling underlies WIN55, 212-2 centrally …
- Hepatocyte growth factor-induced c-Src-Phosphatidylinositol 3–kinase-AKT-mammalian target of rapamycin pathway inhibits dendritic cell activation by blocking IκB …
- Neural cell adhesion molecule potentiates invasion and metastasis of melanoma cells through CAMP-dependent protein kinase and Phosphatidylinositol 3–kinase …
- Inhibition of Phosphatidylinositol–3 kinase γ reduces pruriceptive, inflammatory, and nociceptive responses induced by trypsin in mice
- Syk activation of Phosphatidylinositol 3–kinase/Akt prevents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein (XIAP) to promote survival of …
- Preliminary evidence of clinical activity in a phase I study of CAL-101, a selective inhibitor of the p1108 isoform of Phosphatidylinositol 3–kinase (P13K), in patients with …
- Class IA Phosphatidylinositol 3–kinase p110α regulates phagosome maturation
- Phosphatidylinositol 3–kinase inhibitor suppresses inducible nitric oxide synthase expression in bronchiole epithelial cells in asthmatic rats
- A role for the Phosphatidylinositol 3–kinase–protein kinase C zeta–Sp1 pathway in the 1, 25-dihydroxyvitamin D3 induction of the 25-hydroxyvitamin D3 24 …
- Mitogen-activated protein kinases and Phosphatidylinositol 3–kinase are involved in Prevotella intermedia-induced proinflammatory cytokines expression in human …
- Shiga toxin 1-induced proinflammatory cytokine production is regulated by the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin signaling pathway
- Rosiglitazone‐induced myocardial protection against ischaemia–reperfusion injury is mediated via a Phosphatidylinositol 3‐kinase/Akt‐dependent pathway
- Glucose activates free fatty acid receptor 1 gene transcription via Phosphatidylinositol–3–kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1
- The Phosphatidylinositol 3‐kinase–Akt pathway protects cardiomyocytes from ischaemic and hypoxic apoptosis via mitochondrial function
- … endothelial nitric-oxide synthase phosphorylation in endothelial cells: role of the AMP-activated protein kinase/estrogen receptor α/Phosphatidylinositol 3–kinase/Akt …
- Keratinocyte Growth Factor (KGF) Regulates Estrogen Receptor-α (ER-α) Expression and Cell Apoptosis via Phosphatidylinositol 3–kinase (PI3K)/Akt Pathway in …
- HMG-CoA reductase inhibitor regulates endothelial progenitor function through the Phosphatidylinositol 3′-kinase/AKT signal transduction pathway
- Preclinical Characterization of PWT143, a Novel Selective and Potent Phosphatidylinositol 3–kinase Delta (PI3K delta) Inhibitor with Ex-Vivo Activity in …
- … endothelial cell adhesion molecule‐1 regulates collagen‐stimulated platelet function by modulating the association of Phosphatidylinositol 3‐kinase with Grb‐2 …
- Concomitant inactivation of the epidermal growth factor receptor, Phosphatidylinositol 3‐kinase/Akt and Janus tyrosine kinase 2/signal transducer and activator of …
- FgTep1p is linked to the Phosphatidylinositol‐3 kinase signalling pathway and plays a role in the virulence of Fusarium graminearum on wheat
- … proliferation by platelet-derived growth factor receptor β-mediated, not by retinoic acid receptor α-mediated, Phosphatidylinositol 3–kinase and ERK signaling …
- Central resistin enhances renal sympathetic nerve activity via Phosphatidylinositol 3‐kinase but reduces the activity to brown adipose tissue via extracellular signal …
- … and breast cancer resistance protein-1 in the brain penetration and brain pharmacodynamic activity of the novel Phosphatidylinositol 3–kinase inhibitor GDC-0941
- Interleukin‐1β‐induced interleukin‐6 production in A549 cells is mediated by both Phosphatidylinositol 3‐kinase and interleukin‐1 receptor‐associated kinase‐4
- Role of Phosphatidylinositol–3–kinase (PI3K), extracellular signal-regulated kinase (ERK) and nuclear transcription factor kappa β (NF-kβ) on neutrophil phagocytic …
- Interim results from a phase I study of CAL-101, a selective oral inhibitor of Phosphatidylinositol 3–kinase p110d isoform, in patients with relapsed or refractory …
- Karanjin from Pongamia pinnata induces GLUT4 translocation in skeletal muscle cells in a Phosphatidylinositol–3–kinase-independent manner
- Phosphatidylinositol 3–kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells
- RNA interference-mediated silencing of the Phosphatidylinositol 3–kinase catalytic subunit attenuates growth of human ovarian cancer cells in vitroand in vivo
- Phosphatidylinositol 3–kinase signaling delays Sendai virus-induced apoptosis by preventing XIAP degradation
- Metallothionein-III provides neuronal protection through activation of Nuclear Factor-κB via the TrkA/Phosphatidylinositol–3 kinase/Akt signaling pathway
- Poly (I: C) induces BLyS-expression of airway fibroblasts through Phosphatidylinositol 3–kinase
- Activation of neuromedin U type 1 receptor inhibits L-type Ca2+ channel currents via Phosphatidylinositol 3–kinase-dependent protein kinase C epsilon pathway in …
- Regulation of autophagic activity by 14-3–3ζ proteins associated with class III Phosphatidylinositol–3–kinase
- The role of Phosphatidylinositol 3–kinase signaling pathways in pancreatic cancer
- Design, Synthesis, and Structure−Activity Relationships of 3-Ethynyl-1H-indazoles as Inhibitors of the Phosphatidylinositol 3–kinase Signaling Pathway
- A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and Phosphatidylinositol 3–kinase signals in human …
- Insulin modulates the inflammatory granulocyte response to streptococci via Phosphatidylinositol 3–kinase
- Fibronectin stimulates endothelial cell 18F-FDG uptake through focal adhesion kinase–mediated Phosphatidylinositol 3–kinase/akt signaling
- Phosphatidylinositol 3–kinase-dependent activation of mammalian protein kinase B/Akt in Saccharomyces cerevisiae, an in vivo model for the functional study …
- Roles of Pichia pastoris Uvrag in vacuolar protein sorting and the Phosphatidylinositol 3–kinase complex in phagophore elongation in autophagy pathways
- Chronic blockade of Phosphatidylinositol 3–kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat
- Structural studies of the Phosphatidylinositol 3–kinase (PI3K) SH3 domain in complex with a peptide ligand: role of the anchor residue in ligand binding
- Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and Phosphatidylinositol 3–kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas
- Dual blockade of Phosphatidylinositol 3′-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer
- Phosphatidylinositol 3–kinase regulates macrophage responses to double-stranded RNA and encephalomyocarditis virus
- … in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the Phosphatidylinositol 3–kinase …
- On the role of Phosphatidylinositol 3–kinase, protein kinase b/Akt, and glycogen synthase kinase–3β in photodynamic injury of crayfish neurons and glial cells
- Induction of insulin resistance by Phosphatidylinositol–3–kinase inhibitor in porcine granulosa cells
- Interferon-γ activates transglutaminase 2 via a Phosphatidylinositol–3–kinase-dependent pathway: implications for celiac sprue therapy
- Inhibition of p85, the non-catalytic subunit of Phosphatidylinositol 3–kinase, exerts potent antitumor activity in human breast cancer cells
- Activation of Phosphatidylinositol 3–kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling and the consequent induction of transformation by …
- Clinical safety and activity in a phase 1 study of CAL-101, an isoform-selective inhibitor of Phosphatidylinositol 3–kinase P110δ, in patients with relapsed or …
- … inhibition of glucose uptake in adipocytes occurs without affecting GLUT4 translocation through an insulin receptor substrate-2-Phosphatidylinositol 3–kinase …
- c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the Phosphatidylinositol 3–kinase/Akt pathway
- A dual effect of porcine reproductive and respiratory syndrome virus replication on the Phosphatidylinositol–3–kinase-dependent Akt pathway
- TGFβ inhibits GM‐CSF‐induced phosphorylation of ERK and MEK in human myeloid leukaemia cell lines via inhibition of Phosphatidylinositol 3‐kinase (PI3‐k)
- … , a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells: synergistic action with LY294002, an inhibitor of Phosphatidylinositol 3′-kinase
- … 1 Contributes to Escherichia coli K1 Invasion of Human Brain Microvascular Endothelial Cells through the Phosphatidylinositol 3–kinase/Akt Signaling Pathway
- Phosphatidylinositol 3‘-kinase, mTOR, and glycogen synthase kinase–3β mediated regulation of p21 in human urothelial carcinoma cells
- Phosphatidylinositol–3–kinase α catalytic subunit gene somatic mutations in bronchopulmonary neuroendocrine tumours
- Induction of MUC5AC mucin by conjugated bile acids in the esophagus involves the Phosphatidylinositol 3‐kinase/protein kinase C/activator protein‐1 pathway
- Peroxisome proliferator-activated receptor γ agonist pioglitazone prevents the hyperglycemia caused by Phosphatidylinositol 3–kinase pathway inhibition by PX-866 …
- Meloxicam protects cell damage from 1-methyl-4-phenyl pyridinium toxicity via the Phosphatidylinositol 3–kinase/Akt pathway in human dopaminergic neuroblastoma …
- Expression of a phosphorylated p130Cas substrate domain attenuates the Phosphatidylinositol 3‐kinase/Akt survival pathway in tamoxifen resistant breast cancer …
- Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent Phosphatidylinositol 3–kinase signaling
- Evidence that Phosphatidylinositol 3–kinase is involved in sperm-induced tyrosine kinase signaling in Xenopus egg fertilization
- Simultaneous inhibition of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase pathways augment the sensitivity to actinomycin D in Ewing sarcoma
- Glimepiride treatment upon reperfusion limits infarct size via the Phosphatidylinositol 3–kinase/Akt pathway in rabbit hearts
- A phase I/II study of the selective Phosphatidylinositol 3–kinase-delta (PI3Kδ) inhibitor, GS-1101 (CAL-101), with ofatumumab in patients with previously treated …
- … protein-coupled receptor kinase 6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting Phosphatidylinositol 3–kinase and inhibiting p38 …
- … binds and dephosphorylates Gα-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-Phosphatidylinositol 3–kinase (PI3K)-Akt signaling …
- … peptidoglycan-induced nuclear factor-κB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the Phosphatidylinositol 3–kinase/Akt …
- The Modulation of Vascular ATP-Sensitive K+ Channel Function via the Phosphatidylinositol 3–kinase–Akt Pathway Activated by Phenylephrine
- Phosphatidylinositol 3′-kinase signaling pathway is essential for Rac1-induced hypoxia-inducible factor-1α and vascular endothelial growth factor expression
- … -like differentiation of prostate cancer cells in the presence of LY294002 through increased ErbB2 expression independent of the Phosphatidylinositol 3–kinase-AKT …
- Activation of Phosphatidylinositol 3–kinase/protein kinase B by corticotropin-releasing factor in human monocytes
- Ligustrazine attenuates myocardial ischemia reperfusion injury in rats by activating the Phosphatidylinositol 3–kinase/Akt pathway
- Role of Phosphatidylinositol 3–kinase pathway (PI3K/Akt) in humans
- Campylobacter jejuni induces an anti-inflammatory response in human intestinal epithelial cells through activation of Phosphatidylinositol 3–kinase/Akt pathway
- Oxytocin increases invasive properties of endometrial cancer cells through Phosphatidylinositol 3–kinase/AKT-dependent up-regulation of cyclooxygenase-1,-2, and X …
- Impaired activation of Phosphatidylinositol 3–kinase by leptin is a novel mechanism of hepatic leptin resistance in NAFLD.
- The SH3 domain of postsynaptic density 95 mediates inflammatory pain through Phosphatidylinositol‐3‐kinase recruitment
- Identification of GSK2636771, a potent and selective, orally bioavailable inhibitor of Phosphatidylinositol 3–kinase-beta (PI3Kα) for the treatment of PTEN deficient …
- Insulin glargine and insulin have identical effects on proliferation and Phosphatidylinositol 3–kinase/AKT signalling in rat thyrocytes and human follicular …
- Identification of functionally distinct TRAF proinflammatory and Phosphatidylinositol 3–kinase/mitogen-activated protein kinase/extracellular signal-regulated …
- Beneficial effects of IH-901 on glucose and lipid metabolisms via activating adenosine monophosphate–activated protein kinase and Phosphatidylinositol–3 kinase …
- … and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue: role of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase …
- … ) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85α subunit of Phosphatidylinositol 3–kinase and S6K1 kinase
- … growth factor beta 3 (TGFβ3) production/secretion through proteinase-activated receptor-1 (PAR-1) and the downstream Phosphatidylinositol 3–kinase (PI3K)-Akt/PKB …
- Hepatocyte growth factor inhibits anoikis of pancreatic carcinoma cells through Phosphatidylinositol 3–kinase pathway
- Phosphatidylinositol–3–kinase-dependent phosphorylation of SLP-76 by the lymphoma-associated ITK-SYK fusion-protein
- Repetitive progressive thermal preconditioning hinders thrombosis by reinforcing Phosphatidylinositol 3–kinase/Akt-dependent heat-shock protein/endothelial …
- Phosphatidylinositol 3–kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction: contribution to transforming growth …
- IL‐12 and IL‐10 Production are Differentially Regulated by Phosphatidylinositol 3‐kinase in Mast Cells
- PIK3CA mutations in endometrial carcinomas in Chinese women: Phosphatidylinositol 3′-kinase pathway alterations might be associated with favorable prognosis
- Roles of Phosphatidylinositol 3‐kinase and p38 mitogen‐activated protein kinase in the regulation of protein kinase C‐α activation in interferon‐γ‐stimulated …
- Phosphatidylinositol 3–kinase and Rab5 GTPase inversely regulate the Smad anchor for receptor activation (SARA) protein independently of transforming …
- … protein 4 stimulates attachment of neurospheres and astrogenesis of neural stem cells in neurospheres via Phosphatidylinositol 3 kinase-mediated upregulation of N …
- … -like growth factor-1 promotes cell cycle progression via upregulation of cyclin D1 expression through the Phosphatidylinositol 3–kinase/nuclear factor-κB …
- … -1-phosphate represses the hydrogen peroxide-induced activation of c-Jun N-terminal kinase in human dermal fibroblasts through the Phosphatidylinositol 3–kinase …
- Hypercholesterolaemic serum increases the permeability of endothelial cells through zonula occludens-1 with Phosphatidylinositol 3–kinase signaling …
- … for Toll‐like receptor‐activated neutrophil exocytosis: key roles for interleukin‐1‐receptor‐associated kinase‐4 and Phosphatidylinositol 3‐kinase but not Toll/IL‐1 …
- Cbl–Phosphatidylinositol 3 kinase interaction differentially regulates macrophage colony‐stimulating factor‐mediated osteoclast survival and cytoskeletal …
- 17β-Oestradiol activates proteolysis and increases invasion through Phosphatidylinositol 3–kinase pathway in human cervical cancer cells
- Laminin acts via focal adhesion kinase/Phosphatidylinositol‐3′ kinase/protein kinase B to down‐regulate β1‐adrenergic receptor signalling in cat atrial myocytes
- Inhibition of cell cycle progression by dual Phosphatidylinositol–3–kinase and mTOR blockade in cyclin D2 positive multiple myeloma bearing IgH …
- Balanced Interactions between Lyn, the p85α Regulatory Subunit of Class IA Phosphatidylinositol–3–kinase, and SHIP Are Essential for Mast Cell Growth and …
- Analysis of Phosphatidylinositol 3–kinase activation in the adipose tissue of gestational diabetes mellitus patients and insulin resistance
- … factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and Phosphatidylinositol 3–kinase
- Arecoline‐induced phosphorylated p53 and p21WAF1 protein expression is dependent on ATM/ATR and Phosphatidylinositol‐3‐kinase in clone‐9 cells
- Involvement of Phosphatidylinositol 3–kinase/Akt on basic fibroblast growth factor-induced glial cell line-derived neurotrophic factor release from rat glioma cells
- Proviral integration site for Moloney murine leukemia virus 1, but not Phosphatidylinositol–3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 …
- Clionosterol and ethyl cholestan-22-enol isolated from the rhizome of Polygala tenuifolia inhibit Phosphatidylinositol 3–kinase/Akt pathway
- Phosphatidylinositol–3–kinase-AKT pathway, phospho-JUN and phospho-JNK expression in spontaneously arising bovine urinary bladder tumours
- Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via Phosphatidylinositol 3–kinase
- A Phase 1 Study of the Selective Phosphatidylinositol 3–kinase-Delta (PI3Kδ) Inhibitor, Cal-101 (GS-1101), in Combination with Rituximab and/or …
- Inhibition of contractile activity during postconditioning enhances cardioprotection by restoring sarcolemmal dystrophin through Phosphatidylinositol 3–kinase
- Effects of deguelin on proliferation and apoptosis of MCF-7 breast cancer cells by Phosphatidylinositol 3–kinase/Akt signaling pathway
- … -2–Triggered Prostaglandin E2 Release, but Not Cyclooxygenase-2 Upregulation, Requires Activation of the Phosphatidylinositol 3–kinase/Akt/Nuclear Factor-κB …
- Synergistic induction of cancer cell migration regulated by Gβγ and Phosphatidylinositol 3–kinase
- Sevoflurane‐and Desflurane‐induced human myocardial post‐conditioning through Phosphatidylinositol‐3‐kinase/Akt signalling
- … methylation of breast and ovarian cancer susceptibility gene 1 in chemosensitive human ovarian cancer cells does not involve the Phosphatidylinositol 3′‐kinase …
- Protein tyrosine phosphatase SHP‐1 positively regulates TLR‐induced IL‐12p40 production in macrophages through inhibition of Phosphatidylinositol 3‐kinase
- Structure of the iSH2 domain of human Phosphatidylinositol 3–kinase p85β subunit reveals conformational plasticity in the interhelical turn region
- Phosphatidylinositol 3‐kinase affects mitochondrial function in part through inducing peroxisome proliferator‐activated receptor γ coactivator‐1β expression
- Cooperative regulation of NOTCH1 protein-Phosphatidylinositol 3–kinase (PI3K) signaling by NOD1, NOD2, and TLR2 receptors renders enhanced …
- … −)-Epigallocatechin gallate attenuates the induction of HSP27 stimulated by sphingosine 1-phosphate via suppression of Phosphatidylinositol 3–kinase/Akt pathway in …
- The Phosphatidylinositol–3 kinase/mTOR pathway: new agents
- Tumor Phosphatidylinositol–3–kinase signaling and development of metastatic disease in locally advanced rectal cancer
- … Signature of Thrombin-Activated Platelets After In Vivo Nitric Oxide–Donor Treatment: Coordinated Inhibition of Signaling (Phosphatidylinositol 3–kinase-γ, 14-3–3ζ …
- Combinations of the Phosphatidylinositol 3–kinase-delta (PI3Kδ) inhibitor Gs-1101 (CAL-101) with rituximab and/or bendamustine are tolerable and highly …
- Possible involvement of Class III Phosphatidylinositol–3–kinase in meiotic progression of porcine oocytes beyond germinal vesicle stage
- Caffeine induces endothelial tissue factor expression via Phosphatidylinositol 3–kinase inhibition
- Phosphatidylinositol 3–kinase/Akt pathway regulates inflammatory mediators-induced calcification of human vascular smooth muscle cells
- CD44-mediated elongated T cell spreading requires Pyk2 activation by Src family kinases, extracellular calcium, phospholipase C and Phosphatidylinositol–3 kinase
- The emerging role of maternal Phosphatidylinositol 3 kinase (PI3K) signaling in manipulating mammalian preimplantation embryogenesis
- Phosphatidylinositol 3–kinase p85α regulatory subunit gene Met326Ile polymorphism in women with polycystic ovary syndrome
- Inhibitors of Phosphatidylinositol 3–kinase and mTOR but not Akt enhance replication of bovine ephemeral fever virus
- … acid 2‐phosphate promotes elongation of hair shafts via the secretion of insulin‐like growth factor‐1 from dermal papilla cells through Phosphatidylinositol 3‐kinase
- … aldo–keto reductase 1C3 expression in human nasal septum carcinoma RPMI-2650 cells: Involvement of reactive oxygen species and Phosphatidylinositol 3–kinase …
- … . Focus on “L-thyroxine vs. 3, 5, 3′-triiodo-L-thyronine and cell proliferation: Activation of mitogen-activated protein kinase and Phosphatidylinositol 3–kinase”
- Upregulation of stromal cell–derived factor by IL‐17 and IL‐18 via a Phosphatidylinositol 3‐kinase‐dependent pathway
- Phase I trial of SAR245408 (S08), a pan-Phosphatidylinositol 3 kinase (PI3K) inhibitor, in patients with chronic lymphocytic leukemia (CLL) and lymphoma
- … stimulates chemokinesis and TNF stimulates chemotaxis of tissue mast cells: involvement of both mitogen‐activated protein kinases and Phosphatidylinositol 3‐kinase …
- Synthesis and structure–activity relationships of 1, 2, 4-triazolo [1, 5-a] pyrimidin-7 (3H)-ones as novel series of potent β isoform selective Phosphatidylinositol 3–kinase …
- Possible involvement of Phosphatidylinositol 3‐kinase in the maintenance of metaphase II attest in porcine oocytes matured in vitro
- Histidine-rich glycoprotein and concanavalin A synergistically stimulate the Phosphatidylinositol 3–kinase-independent signaling pathway in leukocytes leading to …
- Expression of Glucose Transporter-1, Hypoxia-Inducible Factor-1α, Phosphatidylinositol 3–kinase and Protein kinase B (Akt) in Relation to [18F]Fluorodeoxyglucose …
- 14‐3‐3 inhibits insulin‐like growth factor‐I‐induced proliferation of cardiac fibroblasts via a Phosphatidylinositol 3‐kinase‐dependent pathway
- Ovarian expressed microsomal epoxide hydrolase: role in detoxification of 4-vinylcyclohexene diepoxide and regulation by Phosphatidylinositol–3 kinase signaling
- … (CKD712) Reduces Rat Myocardial Apoptosis against Ischemia and Reperfusion Injury by Activation of Phosphatidylinositol 3–kinase/Akt Signaling and Anti …
- Enhanced antitumor efficacy by blocking activation of the Phosphatidylinositol 3‐kinase/Akt pathway during anti‐angiogenesis therapy
- Erythropoietin protects pancreatic β-cell line NIT-1 cells against cytokine-induced apoptosis via Phosphatidylinositol 3–kinase/Akt signaling
- Extracellular signal-regulated kinase and Phosphatidylinositol–3–kinase/AKT signalling pathways in the human carotid body and peripheral ganglia
- Involvement of Phosphatidylinositol 3–kinase/Akt pathway in gemcitabine-induced apoptosis-like cell death in insulinoma cell line INS-1
- Curcumin protects SH-SY5Y cells from oxidative stress by up-regulating HO-1 via Phosphatidylinositol 3 kinase/Akt/Nrf-2 and down-regulating HO-2
- The role of Phosphatidylinositol–3–kinase and AMP-activated kinase in the rapid estrogenic attenuation of cannabinoid-induced changes in energy homeostasis
- Effect of Phosphatidylinositol 3–kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats
- The Phosphatidylinositol 3′ kinase-Akt-mammalian target of rapamycin pathway in smooth muscle tumors of the uterus: selected protein expression patterns and …
- Role of Phosphatidylinositol 3–kinase in friend spleen focus-forming virus-induced erythroid disease
- Phosphatidylinositol–3–kinase activity during in vitro dendritic cell generation determines suppressive or stimulatory capacity
- Synthesis and structure–activity relationships of imidazo [1, 2-a] pyrimidin-5 (1H)-ones as a novel series of beta isoform selective Phosphatidylinositol 3–kinase …
- Effect of exogenous surfactant on Phosphatidylinositol 3–kinase-Akt pathway and peroxisome proliferator activated receptor-γ during endotoxin induced acute …
- Phosphatidylinositol–3–kinase (PI3K) activity decreases in C2C12 myotubes during acute simulated ischemia at a cost to their survival
- Role of the Phosphatidylinositol 3–kinase and extracellular signal-regulated kinase pathways in the neuroprotective effects of cilnidipine against hypoxia in a primary …
- Cyclin D1 induction by benzo [a] pyrene-7, 8-diol-9, 10-epoxide via the Phosphatidylinositol 3–kinase/Akt/MAPK-and p70s6k-dependent pathway promotes …
- Stanniocalcin 1 induction by thyroid hormone depends on thyroid hormone receptor β and Phosphatidylinositol 3–kinase activation
- Phosphatidylinositol 3–kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway
- Anti‐ribosomal phosphoprotein autoantibody triggers interleukin‐10 overproduction via Phosphatidylinositol 3‐kinase‐dependent signalling pathways in …
- Expression and significance of Phosphatidylinositol 3–kinase/protein kinase B signal transduction pathway in severe acute pancreatitis-associated lung injury
- Imatinib mesylate (STI571) enhances amrubicin-induced cytotoxic activity through inhibition of the Phosphatidylinositol 3–kinase/Akt pathway in small cell lung cancer …
- Evidence of Clinical Activity in a Phase 1 Study of CAL-101, An Oral P110Δ Isoform-Selective Inhibitor of Phosphatidylinositol 3–kinase, in Patients with …
- Retinoblastoma gene‐independent G1 phase arrest by flavone, Phosphatidylinositol 3‐kinase inhibitor, and histone deacetylase inhibitor
- Prognostic implications of Phosphatidylinositol 3–kinase (PI3K) pathway alterations in metastatic triple-negative breast cancer (mTNBC).
- … regulates the switch between adipogenesis and osteogenesis of human mesenchymal stem cells through increasing the activation of Phosphatidylinositol 3–kinase
- Involvement of c-Met-and Phosphatidylinositol 3–kinase dependent pathways in arsenite-induced downregulation of catalase in hepatoma cells
- Phosphatidylinositol–3–kinase related kinases (PIKKs) in radiation-induced DNA damage
- Prunus yedoensis Matsum. stimulates glucose uptake in L6 rat skeletal muscle cells by activating AMP-activated protein kinase and Phosphatidylinositol 3–kinase/Akt …
- Activation of the Phosphatidylinositol–3‘-kinase pathway with lectin-induced signal through sialo-containing glycoproteins of leukocyte membranes under type 1 …
- Impairment of Phosphatidylinositol 3–kinase signaling in schizophrenia: state or trait?
- … metformin treatment synergistically improves insulin signalling to insulin receptor substrate-1-dependent Phosphatidylinositol 3–kinase, atypical protein kinase …
- Electroacupuncture confers beneficial effects through ionotropic glutamate receptors involving Phosphatidylinositol–3 kinase/Akt signaling pathway in focal cerebral …
- Modulation of protein–ligand interactions by photocleavage of a cyclic peptide using Phosphatidylinositol 3‐kinase SH3 domain as model system
- Dual Inhibition of Phosphatidylinositol 3–kinase and Mammalian Target of Rapamycin: a Therapeutic Strategy for Acute Leukemias.
- A phase I study of CAL-101, an isoform-selective inhibitor of Phosphatidylinositol 3‐kinase P110δ, in combination with anti-CD20 monoclonal antibody therapy and/or …
- Activation of Phosphatidylinositol 3–kinase/Akt signaling pathway and endogenous nitric oxide are needed for the antiarrhythmic effect of centrally administered …
- A Phase 1 Study of CAL-101, An Isoform-Selective Inhibitor of Phosphatidylinositol 3–kinase P110δ, In Combination with Rituximab and/or Bendamustine In …
- CAL-101, An Oral p110δ Selective Phosphatidylinositol–3–kinase (PI3K) Inhibitor for the Treatment of B Cell Malignancies Inhibits PI3K Signaling, Cellular Viability …
- Ion transport regulation by P2Y receptors, protein kinase C and Phosphatidylinositol 3–kinase within the semicircular canal duct epithelium
- … protein quantification system in conjunction with tissue microarray technology for identifying predictive biomarkers for Phosphatidylinositol 3–kinase inhibitors
- The Phosphatidylinositol 3–kinase/Akt signaling pathway in neuroendocrine tumors
- ALK+ anaplastic large cell lymphoma exhibits Phosphatidylinositol‐3 kinase/akt activity with retained but inactivated PTEN—A report from the Children’s Oncology …
- Inhibition of the Phosphatidylinositol–3–kinase pathway abrogates polyinosinic: polycytidylic acid–stimulated hyaluronan-mediated human mucosal smooth muscle cell …
- The p110 and p110 Isoforms of Class I Phosphatidylinositol 3–kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells
- DUAL INHIBITION OF CLASS IA Phosphatidylinositol 3–kinase AND mTOR AS A NEW THERAPEUTIC OPTION FOR T-CELL ACUTE …
- Phosphatidylinositol 3–kinase could be a promising target in lung cancer therapy
- Evidence for direct activation of mTORC2 kinase activity by Phosphatidylinositol 3, 4, 5-trisphosphate
- Phosphatidylinositol–3 kinase Delta (PI3Kδ) Inhibitor AMG 319 Is a Potent, Selective and Orally Bioavailable Small Molecule Inhibitor That Suppresses PI3K …
- CAL-101 (GS-1101), a specific inhibitor of Phosphatidylinositol–3–kinase-delta (PI3Kδ), disrupts signals from the microenvironment, induces apoptosis, and …
- Can Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibition ERase them all?
- Resistance to Endocrine Therapy in Estrogen Receptor-Positive (ER+) Breast Cancer Is Dependent upon Phosphatidylinositol–3 kinase (PI3K) Signaling.
- Protective effects of statins on l-DOPA neurotoxicity due to the activation of Phosphatidylinositol 3–kinase and free radical scavenging in PC12 cell culture
- A phase I study of BKM120, a novel oral selective Phosphatidylinositol–3–kinase (PI3K) inhibitor, in combination with fulvestrant in postmenopausal women with …
- … )‐3, 7‐dimethoxy‐4H‐chromen‐4‐one (MSF‐2) suppresses fMLP‐mediated respiratory burst in human neutrophils by inhibiting Phosphatidylinositol 3‐kinase activity
- Phosphatidylinositol–3–kinase pathway
- Mammalian target of rapamycin, Akt, and Phosphatidylinositol 3–kinase signaling
- Rac/ROS-related protein kinase C and Phosphatidylinositol–3–kinase signaling are involved in a negative regulating cascade in B cell activation by antibody-mediated …
- Proteomic analysis of phosphoproteins sensitive to a Phosphatidylinositol 3–kinase inhibitor, ZSTK474, by using SELDI-TOF MS
- Effects induced by inhibitors of the Phosphatidylinositol 3‐kinase/Akt and nitric oxide synthase/guanylyl cyclase pathways on the isometric contraction in rat aorta: a …
- Posttranscriptional regulation of the p85α. Alpha; adapter subunit of Phosphatidylinositol 3–kinase in human leukemia cells
- P26. Inhibition of Phosphatidylinositol–3–kinase signalling promotes Activin A induced definitive endoderm differentiation of human embryonic stem cells
- … of the plasma membrane 5-hydroxytryptamine2A (5-HT2A) receptor in the isolated human endothelium-denuded saphenous vein via the Phosphatidylinositol 3–kinase …
- Function of Phosphatidylinositol 3–kinase Class III in the Nervous System
- Nectandrin B activates eNOS phosphorylation in endothelial cells: Role of the AMP-activated protein kinase/estrogen receptor α/Phosphatidylinositol 3–kinase …
- Different effects of Phosphatidylinositol 3–kinase inhibitor LY294002 and Akt inhibitor SH-5 on cell cycle progression in synchronized HL-60 leukemia cells
- … ‐β‐methyl butyrate (HMB) stimulates mammalian target of rapamycin complex 1 (mTORc1) signaling via a Phosphatidylinositol‐3‐kinase (PI3K)‐dependent pathway
- Low-Intensity Pulsed Ultrasound Promotes Early Proliferation of Knee Articular Chondrocytes by Activating Phosphatidylinositol 3 kinase Pathway in a Rabbit …
- … Patterns of Nodal Response and Lymphocytosis in Patients with Previously Treated CLL Receiving the Selective Phosphatidylinositol 3–kinase-Delta (PI3Kδ) Inhibitor …
- Abstract B136: CAL‐120, a novel dual p110β/p110δ Phosphatidylinositol‐3‐kinase (PI3K) inhibitor, attenuates PI3K signaling and demonstrates potent in vivo …
- Effect of High Fat Diet-Induced Obesity on Ovarian Phosphatidylinositol–3 kinase Signaling Pathway Members in Mice.
- P5-13-01: Survival Outcome with Bevacizumab: Activation of the Phosphatidylinositol–3 kinase (PI3K) Pathway Due to PIK3CA Mutations or PTEN Loss Makes a …
- Effects of alcohol and high-fat diet on the expression of Phosphatidylinositol 3–kinase in rat adipose tissue
- Effects of bushen tongmai recipe on expression of Phosphatidylinositol–3–kinase in PCOS rats accompanying with insulin resistance
- … receptor β/δ (PPARβ/δ) increases the expression of prostaglandin E₂ receptor subtype EP4. The roles of Phosphatidylinositol 3–kinase and CCAAT/enhancer …
- Effects of local hyperthermia on Phosphatidylinositol 3–kinase gene expression in Langerhans cells from human papillomavirus (HPV)-infected skin
- Role of adiponectin/Phosphatidylinositol 3–kinase/protein kinase B signaling pathway on limb ischemic preconditioning on myocardial protection
- Abstract P1-14-01: Phosphatidylinositol 3–kinase (PI3K) Pathway Activation in Breast Cancer Brain Metastases
- Participation of Phosphatidylinositol–3‘-kinase in signal transduction through galactosyl-containing glycoprotein receptors of segmentonuclear leukocytes under type 1 …
- Correction: CTLA-4 activation of Phosphatidylinositol 3–kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death
- … PAJU cells from amyloid beta protein-induced apoptosis by activating the ezrin/radixin/moesin protein family/Phosphatidylinositol–3–kinase/protein kinase B …
- Comment on “Decoy Receptor 3 Expression in AsPC-1 Human Pancreatic Adenocarcinoma Cells via the Phosphatidylinositol 3–kinase-, Akt-, and NF-κB-Dependent …
- Phosphatidylinositol 3–kinase/Akt signaling as a key
- Ghrelin attenuates myocardial ischemia/reperfusion injury via the extracellular signal-regulated kinase 1/2 and Phosphatidylinositol 3–kinase/Akt pathway
- Disruption of Platelet-Derived Growth Factor–Dependent Phosphatidylinositol 3–kinase and Phospholipase C 1 Activity Abolishes Vascular Smooth Muscle Cell …
- Novel strategies for antagonizing the Phosphatidylinositol–3–kinase pathway in disease
- Comprehensive in Vitro and in Vivo Analysis of Phosphatidylinositol–3–kinase Delta (PI3Kδ) Inhibition Using GS-1101 (CAL-101) in Combination with …
- Abstract LB-70: In vitro anti-cancer activity of PF-04691502, a potent dual inhibitor of Phosphatidylinositol 3–kinase (PI3K) and mammalian target of rapamycin (mTOR …
- The program of gene expression regulated by Phosphatidylinositol 3–kinase signaling
- Common Angiogenic Signalling Pathways Induced by Monomeric c-Reactive Protein and FGF-2 Through Phosphatidylinositol 3–kinase
- Blueberry phytochemicals inhibit growth and metastatic potential of MDA‐MB‐231 breast cancer cells through modulation of the Phosphatidylinositol 3‐kinase …
- The relationship between Phosphatidylinositol–3–kinase and insulin resistance.
- Biological Roles and Regulation of Phosphatidylinositol 3–kinase (PI3K) Isoforms
- Investigation of the Phosphatidylinositol 3–kinase pathway in B cells
- Liver Dysfunction and Phosphatidylinositol–3–kinase Signalling in Early Sepsis
- Study of Phosphatidylinositol 3–kinase in the Regulation of Autophagy
- Effects of Phosphatidylinositol 3–kinase inhibitor on human cervical carcinoma cells in vitro
- The effect of Phosphatidylinositol–3–kinase-protein kinase B signal pathway in colon cancer
- Abstract A22: Pooled analysis of Phosphatidylinositol 3‐kinase (PI3K) pathway variants and risk of prostate cancer
- Cellular response to low dose radiation: Role of Phosphatidylinositol–3 kinase like kinases
- Assessment of Phosphatidylinositol–3 kinase (PI3K) as a prognostic marker in head and neck squamous cell carcinoma (HNSCC)
- The regulation of Rab5 by Phosphatidylinositol 3‘-kinase
- Cellular response to low dose radiation: Role of Phosphatidylinositol–3 kinase like kinases
- Expression of Phosphatidylinositol 3–kinase/protein kinase B signaling pathway in cervical cancer and clinical significance
- Age-Related Changes of the Phosphatidylinositol 3–kinase (PI3K)/Akt Signaling in the RPE
- Modulation of Phosphatidylinositol 3–kinase (PI3K) as a tool to enhance anti-polysaccharide antibody response in the aged (45.23)
- Effect of Phosphatidylinositol 3–kinase/serine-threonine kinase signalling pathway during the proliferation process of HL-60 cells exposed to benzoquinone
- Molecular studies of intra-oocyte Phosphatidylinositol 3 kinase (PI3K) signaling pathway in controlling female fertility
- Involvement of Phosphatidylinositol–3 kinase in Ovotoxicity Induced by 4-Vinylcyclohexene Diepoxide.
- Evidence for Phosphatidylinositol–3-OH-kinase (PI3–kinase) involvement in Cd-mediated oxidative effects on hemocytes of mussels
- Deficiency of Phosphatidylinositol 3–kinase (PI3K) aggravates inflammation and fibrosis in experimental NASH in vivo
- The Role of Phosphatidylinositol 3–kinase in P2X7R Gated Signalling in T Lymphocytes
- Phosphorylation of MNAR Promotes Estrogen Activation of Phosphatidylinositol 3–kinase
- Inhibition of Phosphatidylinositol 3‐kinase facilitates proton‐induced apoptosis of B lymphoma cells
- Effects of Isoform-selective Phosphatidylinositol–3 kinase Inhibitors on Osteoclasts
- Expression of Phosphatidylinositol–3–kinase in the lesions of psoriasis and some skin tumors.
- Activation of Phosphatidylinositol 3–kinase/Akt signaling pathway and endogenous nitric oxide are needed for the antiarrhythmic effect of centrally administered …
- Effect of BRL37344 on cardiac fibroblast Phosphatidylinositol 3–kinase-protein kinase B signal transduction pathway
- The functional roles of the intra-oocyte Phosphatidylinositol 3–kinase (PI3K) signaling in controlling follicular development in mice
- Involvement of c-Src tyrosine kinase upstream of class I Phosphatidylinositol (PI) 3–kinases in Salmonella Enteritidis Rck protein-mediated invasion
- Lenalidomide-Dependent Activation of the Phosphatidylinositol 3–kinase-δ Pathway Is Antagonized by CAL-101 In Chronic Lymphocytic Leukemia
- Development of a Novel Phosphatidylinositol 3–kinase Inhibitor with Anticancer Activities against Human Liver Cancer
- Roles of the Phosphatidylinositol 3–kinase regulatory subunit p55gamma on regulating survival signaling in breast cancer cells
- Phosphatidylinositol 3‐kinase mediates the ability of retinol to inhibit colon cancer cell invasion in vitro
- Phosphatidylinositol 3–kinase/akt signaling mediates interleukin-32α induction in human pancreatic periacinar myofibroblasts
- IKBKE activates Akt independent of Phosphatidylinositol 3–kinase/PDK1/mTORC2 to sustain malignant transformation
- Phosphatidylinositol 3–kinase-independent rapid activation of vascular endothelial growth factor in neuroblastoma
- Phosphatidylinositol 3–kinase/Glycogen Synthase kinase and Mitogen-Activated Protein kinase Signalling Cascades in Neuronal Cell Survival: What the …
- Effect of Phosphatidylinositol 3–kinase on inducible nitric oxide synthase in bronchiole epithelial cells of asthmatic rat
- Analysis of candidate Phosphatidylinositol 3‘kinase inhibitor biomarkers in matched synchronous primary and metastatic breast cancer tumors
- Phosphatidylinositol 3–kinase p85 regulatory subunit gene and spinal muscular atrophy disease
- 8-Prenylnaringenin inhibits epidermal growth factor-induced MCF-7 breast cancer cell proliferation by targeting Phosphatidylinositol–3-OH kinase activity
- Phosphatidylinositol–3 kinase/AKT and Fos like protein 1 regulation of trophoblast differentiation
- Investigation of activated Phosphatidylinositol 3‘kinase signaling in stem cell self-renewal and tumorigenesis
- Studies in phagosome maturation: modulation by both the host Phosphatidylinositol 3–kinase p110alpha and the mycobacterial protein PE-PGRS62
- Abstract# 92: Pooled analysis of variants in the Phosphatidylinositol 3–kinase (PI3K) pathway and risk of prostate cancer
- … Stress Modulates The Expression Of Phenotype Marker Proteins In Airway Smooth Muscle (ASM) Tissues By A Phosphatidylinositol 3–kinase (PI3–kinase)/Akt …
- Activated Phosphatidylinositol–3 kinase: An oncogene that increases gap junctional, intercellular communication
- Structure of the iSH2 domain of human Phosphatidylinositol 3–kinase p85b subunit reveals conformational plasticity in the interhelical turn region
- Progesterone receptor B induces autophagy antagonizing the Phosphatidylinositol–3 kinase PI3K/AKT pathway in breast cancer cell lines
- Effects of Phosphatidylinositol–3 kinase/serine threonine kinase pathway on expression of beta-site amyloid precursor protein cleaving enzyme-1 in the hippocampus …
- Development of New Molecular Markers for Cancer: A Highly Sensitive Assay for Detecting Mutations of Phosphatidylinositol 3–kinase and p53
- Expressions of Phosphatidylinositol 3 kinase and phosphorylated Akt in condyloma acuminatum and cervical squamous cell carcinoma
- Modulating the Phosphatidylinositol 3–kinase/mammalian target of rapamycin pathway for therapeutic enhancement of photodynamic therapy
- Mechanisms of integration for androgen receptor and Phosphatidylinositol 3–kinase signaling in estrogen receptor negative class A breast cancer
- Suppression of Collagen Production by miR-29b Via Phosphatidylinositol 3–kinase, Akt, and Sp1 in Human Tenon’s Fibroblasts
- Role of Phosphatidylinositol 3–kinase and myosin light chain kinase during the activation of thrombin receptors
- In-silico Molecular Docking and Virtual Pharmacokinetic Screening study of Psoralidin and its Derivatives as Phosphatidylinositol 3–kinase Inhibitors
- Phosphatidylinositol 3–kinase/Akt Pathway Regulates TGF-ß Signaling by De-stabilizing Ski and Inducing Smad7
- Inducing vascular smooth muscle cell proliferation by insulin involves in Phosphatidylinositol 3–kinase and ERK1/2
- Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the Phosphatidylinositol 3-phosphate kinase/mammalian …
- ER Stress is Linked to the Regulation of Hepatic Gluconeogenesis and Phosphatidylinositol 3–kinase/Akt Signaling Post Burn Injury
- Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting Phosphatidylinositol-(3, 4, 5)-trisphosphate signaling
- Role of Phosphatidylinositol–3–kinase (PI3K) in TGF-β-induced proliferation and differentiation of human lung fibroblasts into myofibroblasts
- Class I [sub A] Phosphatidylinositol 3–kinase p110 alpha: a critical mediator for cell proliferation, survival and tumour formation in small cell lung cancer and …
- Insulin-like Growth Factor-I Suppresses Bone Morphogenetic Protein Signaling through a Phosphatidylinositol 3–kinase, Akt and mTOR-Dependant Mechanism
- Linoleic acid supplementation upregulates Phosphatidylinositol–3–kinase signaling by increasing the association between Gab1 and EGFR
- A bovel Phosphatidylinositol 3–kinase (PI3K) inhibitor, HS-106, induces apoptosis and inhibits angiogenesis of breast carcinoma by targeting PI3K/mTOR …
- Short-term romidepsin treatment combined with mitogen-activated protein kinase and Phosphatidylinositol 3–kinase inhibition causes increased Bim expression and …
- Progesterone receptor B induces autophagy antagonizing the Phosphatidylinositol–3 kinase PI3K/AKT pathway in breast cancer cell lines. http://www. endocrine …
- Atrial Natriuretic Peptide (ANP) Activates Pancreatic Islet Phosphatidylinositol‐3′‐kinase (PI3K)/Akt/FoxO1a/Cyclin D2 Signaling
- The Role Of Class I Phosphatidylinositol–3–kinase In TNF-Alpha-Induced CD38 Expression In Human Airway Smooth Muscle Cells
- Phosphoinositide-dependent protein kinase (PDK) activity regulates Phosphatidylinositol 3, 4, 5-trisphosphate-dependent and-independent protein kinase B …
- Dual Targeting Glioblastoma Multiforme (GBM) with a Phosphatidylinositol 3–kinase inhibitor (ZSTK474) and a Proteasome Inhibitor (Velcade)
- Inhibition of the Phosphatidylinositol–3–kinase pathway is selectively cytotoxic to primitive and mature acute myeloid leukemia progenitor cells while sparing their …
- Interleukin 10 (IL‐10) inhibits GABAergic transmission in rat hippocampal neurons by a mechanism involving Phosphatidylinositol 3‐kinase
- … ‐gamma (IFN γ) induced epithelial barrier dysfunction in T84 human intestinal epithelial cells (IECs) occurs via Phosphatidylinositol 3‐kinase (PI3‐K) mediated …
- Abstract# 2302: NVP-BEZ235 a dual inhibitor of Phosphatidylinositol 3–kinase (PI3 kinase) and mammalian target of rapamycin (mTOR) potently enhances the effects …
- Role of Phosphatidylinositol 3–kinase/protein-serine-threonine kinases signal transduction pathway in EphB receptor-mediated neuropathic pain in rats
- Deficiency of Phosphatidylinositol 3–kinase (PI3K) aggravates hepatic inflammation and fibrosis in experimental NASH but protects against bile duct ligation induced …
- Inhibition of Phosphatidylinositol 3–kinase Is Effective to Suppress the Growth of CD20-Negative Refractory Diffuse Large B-Cell Lymphoma Cells
- … A2A Receptor Facilitates Calcium-Dependent Protein Secretion through the Activation of Protein kinase A and Phosphatidylinositol–3 kinase in PC12 Cells
- A Highlights from MBoC Selection: A Phosphatidylinositol 3–kinase/Protein kinase B-independent Activation of Mammalian Target of Rapamycin Signaling Is …
- ROLE OF Phosphatidylinositol 3–kinase AND Akt IN THE INDUCTION OF PROTEASOME EXPRESSION BY PROTEOLYSIS-INDUCING FACTOR IN …
- 265 INHIBITION OF CLASS III Phosphatidylinositol–3–kinase, BY 3-METHYLADENINE, REVERSIBLY ARRESTS PORCINE OOCYTES AT GERMINAL …
- Relaxin Improves Experimentally Induced Endothelial Dysfunction Via Phosphatidylinositol 3–kinase Signaling and Glucocorticoid Receptor-Mediated Effects
- Leptin induced inhibition and stimulation of action current firing of nonpreganglionic Edinger-Westphal neurons is dependent on Phosphatidylinositol–3 kinase
- Roles of Phosphatidylinositol 3 kinase in silica-induced DNA double strand breaks damage repair in human embryo lung fibroblasts
- Abstract# 2818: Growth inhibition of human breast cancer cells with an iron chelator and a dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor
- Abstract# 3820: Membrane localization and Phosphatidylinositol 3 kinase (PI3K)-independent AKT phosphorylation by PDK1
- Deficiency of Phosphatidylinositol 3–kinase (PI3K) aggravates inflammation and fibrosis in experimental non alcoholic steatohepatitis but protects against bile duct …
- … /ROCK Signaling Regulates TGF-beta1 Expression and Its Promoter Activity Via Protein-Tyrosine kinase and Phosphatidylinositol 3–kinase Dependent Pathway in …
- HSP27 stimulated by sphingosine 1-phosphate via suppression of Phosphatidylinositol 3–kinase/Akt pathway in osteoblasts
- Response to Comment on “Decoy Receptor 3 Expression in AsPC-1 Human Pancreatic Adenocarcinoma Cells via the Phosphatidylinositol 3–kinase-, Akt-, and NF-κB …
- The regulation of heat shock factor 1 by Akt and Phosphatidylinositol 3–kinase.
- Correction: Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3 0 kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models
- … )‐3, 7‐dimethoxy‐4H‐chromen‐4‐one (MSF‐2) suppresses fMLP‐mediated respiratory burst in human neutrophils by inhib‐iting Phosphatidylinositol 3‐kinase activity
- Pyrazolo [1, 5-a] pyridines: alpha-isoform-selective inhibitors of Phosphatidylinositol–3–kinase (PI3K)
- … generated through NADPH oxidase to abnormal calcium signals in dystrophic skeletal muscle cells: involvement of Phosphatidylinositol–3–kinase and protein kinase …
- Up-Regulation of Stromal Cell-Derived Factor by IL-17 and IL-18 via Phosphatidylinositol 3–kinase Dependent Pathway (171.8)
- A phosphodiesterase 3B‐based signaling complex integrates exchange protein activated by cAMP 1 and Phosphatidylinositol 3‐kinase signals in human arterial …
- … murine Guanylate-Binding Protein-2 (mGBP-2) inhibits Fibronectin and PDGF-dependent Rac activation during cell spreading: role for Phosphatidylinositol 3–kinase …
- … )‐3, 7‐dimethoxy‐4H‐chromen‐4‐one (MSF‐2), a natural lignan extract from Melicope Semecarpifolia: specific inhibition of Phosphatidylinositol 3‐kinase activity
- … -2 Inhibits Rac Activation during Cell Spreading on Fibronectin and after Platelet-derived Growth Factor Treatment: Role for Phosphatidylinositol 3–kinase
- Glucose uptake in rat skeletal muscle L6 cells is increased by low-intensity electrical current through the activation of the Phosphatidylinositol–3-OH kinase (PI-3K)/Akt …
- Abstract P5-06-10: ErbB Signaling Is Required for Activation of Phosphatidylinositol–3 kinase and Transformation of Mammary Epithelial Cells by Polyomavirus Middle …
- Crucial role of Phosphatidylinositol 4-kinase IIIα in development of zebrafish pectoral fin is linked to phosphoinositide 3–kinase and FGF signaling
- Phosphatidylinositol 3–kinase, growth disorders, and cancer
- Phosphatidylinositol 3–kinase (PI3K) inhibitors as cancer therapeutics
- Class I Phosphatidylinositol 3–kinase inhibitors for cancer therapy
- Architecture and dynamics of the autophagic Phosphatidylinositol 3–kinase complex
- Phosphatidylinositol 3–kinase (PI3K) and Phosphatidylinositol 3–kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring
- Discovery of NVP-BYL719 a potent and selective Phosphatidylinositol–3 kinase alpha inhibitor selected for clinical evaluation
- Landscape of Phosphatidylinositol–3–kinase pathway alterations across 19 784 diverse solid tumors
- Safety and tolerability of Phosphatidylinositol–3–kinase (PI3K) inhibitors in oncology
- Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer
- Phosphatidylinositol 3–kinase/Akt signaling as a key mediator of tumor cell responsiveness to radiation
- Phosphatidylinositol 3–kinase α–selective inhibition with alpelisib (BYL719) in PIK3CA-altered solid tumors: results from the first-in-human study
- Atg38 is required for autophagy-specific Phosphatidylinositol 3–kinase complex integrity
- Members of the autophagy class III Phosphatidylinositol 3–kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs
- Architecture and activation of Phosphatidylinositol 3–kinase related kinases
- Phosphatidylinositol 3–kinase δ blockade increases genomic instability in B cells
- The Phosphatidylinositol 3–kinase/Akt and c-Jun N-terminal kinase signaling in cancer: Alliance or contradiction?
- Idelalisib, an inhibitor of Phosphatidylinositol 3–kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia
- Dynamics and architecture of the NRBF2-containing Phosphatidylinositol 3–kinase complex I of autophagy
- Regulation of LC3 lipidation by the autophagy-specific class III Phosphatidylinositol–3 kinase complex
- Idelalisib, a selective inhibitor of Phosphatidylinositol 3–kinase-δ, as therapy for previously treated indolent non-Hodgkin lymphoma
- Herpesviruses in the activated Phosphatidylinositol–3–kinase-δ syndrome
- Class III Phosphatidylinositol 3–kinase and its catalytic product P tdIns3 P in regulation of endocytic membrane traffic
- Safety, tolerability, and management of toxic effects of Phosphatidylinositol 3–kinase inhibitor treatment in patients with cancer: a review
- Attenuation of the Phosphatidylinositol 3–kinase/Akt signaling pathway by Porphyromonas gingivalis gingipains RgpA, RgpB, and Kgp
- Role of synaptic Phosphatidylinositol 3–kinase in a behavioral learning response in C. elegans
- Phosphatidylinositol 3–kinase signaling as a therapeutic target for cervical cancer
- Phosphatidylinositol 3–kinase signaling determines kidney size
- SHORT syndrome with partial lipodystrophy due to impaired Phosphatidylinositol 3 kinase signaling
- Phosphatidylinositol 3–kinase-AKT-mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway in non-small cell lung cancer
- A Phosphatidylinositol 3–kinase effector alters phagosomal maturation to promote intracellular growth of Francisella
- Phosphatase and tensin homolog (PTEN) mutation can cause activated Phosphatidylinositol 3–kinase δ syndrome–like immunodeficiency
- Discovery of selective Phosphatidylinositol 3–kinase inhibitors to treat hematological malignancies
- Phosphatidylinositol 3‐kinase pathway genomic alterations in 60,991 diverse solid tumors informs targeted therapy opportunities
- Frequent Phosphatidylinositol–3–kinase mutations in proliferative breast lesions
- Stat5 regulates the Phosphatidylinositol 3–kinase/Akt1 pathway during mammary gland development and tumorigenesis
- NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked Phosphatidylinositol–3 kinase III activity
- Targeting the Phosphatidylinositol 3–kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway: an emerging treatment strategy for squamous cell lung …
- Targeting the Phosphatidylinositol 3–kinase/AKT pathway for the treatment of multiple myeloma
- Phosphatidylinositol 3–kinase and COPII generate LC3 lipidation vesicles from the ER-Golgi intermediate compartment
- Ablation of periostin inhibits post-infarction myocardial regeneration in neonatal mice mediated by the Phosphatidylinositol 3 kinase/glycogen synthase kinase 3β …
- Pan-Phosphatidylinositol 3–kinase inhibition with buparlisib in patients with relapsed or refractory non-Hodgkin lymphoma
- Therapeutic effect of a novel Phosphatidylinositol–3–kinase δ inhibitor in experimental epidermolysis bullosa acquisita
- VMP1 is a new player in the regulation of the autophagy-specific Phosphatidylinositol 3–kinase complex activation
- Buparlisib in patients with recurrent glioblastoma harboring Phosphatidylinositol 3–kinase pathway activation: an open-label, multicenter, multi-arm, phase II …
- Enhanced Phosphatidylinositol 3–kinase (PI3K)/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress
- Cellular entry of human papillomavirus type 16 involves activation of the Phosphatidylinositol 3–kinase/Akt/mTOR pathway and inhibition of autophagy
- Characterization of heparanase-induced Phosphatidylinositol 3–kinase-AKT activation and its integrin dependence
- Differential Phosphatidylinositol–3–kinase-Akt-mTOR activation by Semliki Forest and chikungunya viruses is dependent on nsP3 and connected to replication complex …
- Phosphatidylinositol 3–kinase delta pathway: a novel therapeutic target for Sjögren’s syndrome
- Anticarcinogenic action of quercetin by downregulation of Phosphatidylinositol 3–kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular …
- Biophysical aspect of Phosphatidylinositol 3–kinase and role of oncogenic mutants (E542K & E545K)
- Critical role for Phosphatidylinositol–3 kinase Vps34/PIK3C3 in ON-bipolar cells
- Inhibition of Phosphatidylinositol 3‐kinase α (PI 3Kα) prevents heterotopic ossification
- In Vitro Antimetastatic Effect of Phosphatidylinositol 3–kinase Inhibitor ZSTK474 on Prostate Cancer PC3 Cells
- The Phosphatidylinositol 3–kinase Pathway as a Potential Therapeutic Target in Bladder CancerPI3K Pathway as a Therapeutic Target for Bladder Cancer
- Oncogenic activity of the regulatory subunit p85β of Phosphatidylinositol 3–kinase (PI3K)
- The long non-coding RNA SNHG12 promotes gastric cancer by activating the Phosphatidylinositol 3–kinase/AKT pathway
- Activation of Phosphatidylinositol 3–kinase/AKT/snail signaling pathway contributes to epithelial-mesenchymal transition-induced multi-drug resistance to …
- … ATPase is increased during cluster disruption-induced maturation of dendritic cells through a Phosphatidylinositol 3–kinase/mTOR-dependent pathway
- The Phosphatidylinositol 3, 4, 5-trisphosphate (PI (3, 4, 5) P3) binder Rasa3 regulates phosphoinositide 3–kinase (PI3K)-dependent integrin αIIbβ3 outside-in …
- The West Nile virus capsid protein blocks apoptosis through a Phosphatidylinositol 3–kinase-dependent mechanism
- Phosphatidylinositol–3 kinase inhibitors, buparlisib and alpelisib, sensitize estrogen receptor-positive breast cancer cells to tamoxifen
- Fine particulate matter leads to reproductive impairment in male rats by overexpressing Phosphatidylinositol 3–kinase (PI3K)/protein kinase B (Akt) signaling pathway
- First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan–Class I Phosphatidylinositol–3–kinase (PI3K) Inhibitor, in Patients with Advanced Solid TumorsFIH …
- Novel regulation of CD80/CD86-induced Phosphatidylinositol 3–kinase signaling by NOTCH1 protein in interleukin-6 and indoleamine 2, 3-dioxygenase …
- The fibrotic role of Phosphatidylinositol–3–kinase/Akt pathway in injured skeletal muscle after acute contusion
- Endocrine resistance in breast cancer: focus on the Phosphatidylinositol 3–kinase/akt/mammalian target of rapamycin signaling pathway
- First-in-human phase I study of GSK2126458, an oral pan-class I Phosphatidylinositol–3–kinase inhibitor, in patients with advanced solid tumor malignancies
- Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the Phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target …
- Cutting edge: TGF-β and Phosphatidylinositol 3–kinase signals modulate distinct metabolism of regulatory T cell subsets
- Assessing the efficacy of targeting the Phosphatidylinositol 3–kinase/AKT/mTOR signaling pathway in endometrial cancer
- Assessment of functional Phosphatidylinositol 3–kinase pathway activity in cancer tissue using forkhead box-O target gene expression in a knowledge-based …
- Klebsiella pneumoniae translocates across the intestinal epithelium via Rho GTPase-and Phosphatidylinositol 3–kinase/Akt-dependent cell invasion
- Inhibition of focal adhesion kinase induces apoptosis in bladder cancer cells via Src and the Phosphatidylinositol 3–kinase/Akt pathway
- … effect by hydroxyapatite nanospheres: Activation of mitochondria-dependent apoptosis and negative regulation of Phosphatidylinositol–3–kinase/protein kinase B …
- A phase Ib study of BEZ235, a dual inhibitor of Phosphatidylinositol 3–kinase (PI3K) and mammalian target of rapamycin (mTOR), in patients with advanced renal cell …
- Wnt5a promotes migration of human osteosarcoma cells by triggering a Phosphatidylinositol–3 kinase/Akt signals
- Oncogenic mutations weaken the interactions that stabilize the p110α‐p85α heterodimer in Phosphatidylinositol 3‐kinase α
- A novel splenic B1 regulatory cell subset suppresses allergic disease through Phosphatidylinositol 3–kinase–Akt pathway activation
- High fat diet induced obesity alters ovarian Phosphatidylinositol–3 kinase signaling gene expression
- Ultrafine particulate matter impairs mitochondrial redox homeostasis and activates Phosphatidylinositol 3–kinase mediated DNA damage responses in lymphocytes
- HS-173, a novel Phosphatidylinositol 3–kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis
- Signaling through the Phosphatidylinositol 3–kinase (PI3K)/mammalian target of rapamycin (mTOR) axis is responsible for aerobic glycolysis mediated by …
- Oleuropein induces apoptosis via activation of caspases and suppression of Phosphatidylinositol 3–kinase/protein kinase B pathway in HepG2 human …
- Phosphatidylinositol–3–kinase (PI3K)/Akt signaling is functionally essential in myxoid liposarcoma
- PI3K (Phosphatidylinositol 3–kinase) activation and endothelial cell proliferation in patients with hemorrhagic hereditary telangiectasia type 1
- Essential role of class II Phosphatidylinositol–3–kinase-C2α in sphingosine 1-phosphate receptor-1-mediated signaling and migration in endothelial cells
- Insulin and the Phosphatidylinositol 3–kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract
- Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-κB and MAPKs activation via the Phosphatidylinositol 3–kinase …
- Copanlisib: an intravenous Phosphatidylinositol 3–kinase (PI3K) inhibitor for the treatment of relapsed follicular lymphoma
- Phosphatidylinositol 3‐kinase inhibition potentiates glucocorticoid response in B‐cell acute lymphoblastic leukemia
- Pictilisib PI3Kinase inhibitor (a Phosphatidylinositol 3–kinase [PI3K] inhibitor) plus paclitaxel for the treatment of hormone receptor-positive, HER2-negative …
- The class III Phosphatidylinositol 3–kinase Vps34 in Saccharomyces cerevisiae
- … with cisplatin synergistically inhibits non‐small‐cell lung cancer in vitro and in vivo via down‐regulating the Phosphatidylinositol 3‐kinase/Akt signalling pathway
- Phosphatidylinositol 3–kinase-δ (PI3K-δ) is a potential therapeutic target in adult T-cell leukemia-lymphoma
- First-in-human phase I study of copanlisib (BAY 80-6946), an intravenous pan-class I Phosphatidylinositol 3–kinase inhibitor, in patients with advanced solid …
- Design, synthesis, and biological evaluation of substituted pyrimidines as potential Phosphatidylinositol 3–kinase (PI3K) inhibitors
- Phosphatidylinositol 3–kinase and 4-kinase Have Distinct Roles in Intracellular Trafficking of Cellulose Synthase Complexes in Arabidopsis thaliana
- … neurogenesis and reverses cognitive deficits in an amyloid-β toxin-induced Alzheimer rat model via the Phosphatidylinositol 3–kinase (PI3K)/Akt/Wnt/β …
- Small GTPase Rab8a-recruited Phosphatidylinositol 3–kinase γ regulates signaling and cytokine outputs from endosomal toll-like receptors
- Role of c-Met/Phosphatidylinositol 3–kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species …
- Tetramethylpyrazine promotes migration of neural precursor cells via activating the Phosphatidylinositol 3–kinase pathway
- Promotion of melanoma cell invasion and tumor metastasis by microcystin-LR via Phosphatidylinositol 3–kinase/AKT pathway
- Sulforaphane prevents human platelet aggregation through inhibiting the Phosphatidylinositol 3–kinase/Akt pathway
- Branching the Tel2 pathway for exact fit on Phosphatidylinositol 3–kinase-related kinases
- Quercetin disrupts tyrosine-phosphorylated Phosphatidylinositol 3–kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB …
- Activation of Phosphatidylinositol 3–kinase/Akt signaling mediates sorafenib-induced invasion and metastasis in hepatocellular carcinoma
- Korean Red Ginseng inhibits apoptosis in neuroblastoma cells via estrogen receptor β-mediated Phosphatidylinositol–3 kinase/Akt signaling
- TLR signalling affects sperm mitochondrial function and motility via Phosphatidylinositol 3–kinase and glycogen synthase kinase–3α
- Activation of spinal Phosphatidylinositol 3–kinase/protein kinase B mediates pain behavior induced by plantar incision in mice
- Efficacy of Phosphatidylinositol‐3 kinase inhibitors with diverse isoform selectivity profiles for inhibiting the survival of chronic lymphocytic leukemia cells
- Phosphatidylinositol 3‐kinase β and β isoforms play key roles in metastasis of prostate cancer DU145 cells
- Nerve growth factor (NGF) regulates activity of nuclear factor of activated T-cells (NFAT) in neurons via the Phosphatidylinositol 3–kinase (PI3K)-Akt-glycogen …
- Targeting the Phosphatidylinositol 3‐kinase/Akt/mechanistic target of rapamycin signaling pathway in B‐lineage acute lymphoblastic leukemia: An update
- Osthole relaxes pulmonary arteries through endothelial Phosphatidylinositol 3–kinase/Akt-eNOS-NO signaling pathway in rats
- Helicobacter pylori promotes eukaryotic protein translation by activating Phosphatidylinositol 3 kinase/mTOR
- Treating cancer with Phosphatidylinositol–3–kinase inhibitors: increasing efficacy and overcoming resistance
- Phosphatidylinositol‐3‐kinase pathway aberrations in gastric and colorectal cancer: Meta‐analysis, co‐occurrence and ethnic variation
- TAPP adaptors control B cell metabolism by modulating the Phosphatidylinositol 3–kinase signaling pathway: a novel regulatory circuit preventing autoimmunity
- Effects of isoform-selective Phosphatidylinositol 3–kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption
- MDM2 regulates hypoxic hypoxia-inducible factor 1α stability in an E3 ligase, proteasome, and PTEN-Phosphatidylinositol 3–kinase-AKT-dependent manner
- Hyperglycemia and Phosphatidylinositol 3–kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) inhibitors in phase I trials: incidence, predictive …
- Targeting the Phosphatidylinositol–3–kinase pathway in gastric cancer: can omics improve outcomes?
- Rab39a interacts with Phosphatidylinositol 3–kinase and negatively regulates autophagy induced by lipopolysaccharide stimulation in macrophages
- Roles of glucose transporter-1 and the Phosphatidylinositol 3‑kinase/protein kinase B pathway in cancer radioresistance
- Pharmacological postconditioning with tanshinone IIA attenuates myocardial ischemia‑reperfusion injury in rats by activating the Phosphatidylinositol 3‑kinase …
- Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and Phosphatidylinositol 3–kinase (PI3K) oncogenic targets with a bifunctional inhibitor
- … and KIT gatekeeper mutations confer polyclonal primary imatinib resistance in GI stromal tumors: relevance of concomitant Phosphatidylinositol 3–kinase/AKT …
- Phosphatidylinositol 3–kinase/Akt mediates integrin signaling to control RNA polymerase I transcriptional activity
- Advances in the researches on the biological activities and inhibitors of Phosphatidylinositol 3–kinase
- Role of Phosphatidylinositol 3–kinase (PI3K), mitogen-activated protein kinase (MAPK), and protein kinase C (PKC) in calcium signaling pathways linked to …
- ZSTK474, a specific class I Phosphatidylinositol 3–kinase inhibitor, induces G1 arrest and autophagy in human breast cancer MCF-7 cells
- … phagosome maturation and regulates inflammatory mediator production through the protein kinase a–Phosphatidylinositol 3 kinase–p38 mitogen-activated …
- Autophagy restricts proliferation driven by oncogenic Phosphatidylinositol 3–kinase in three-dimensional culture
- Inhibition of Phosphatidylinositol 3–kinase/Akt signaling attenuates hypoxia-induced pulmonary artery remodeling and suppresses CREB depletion in arterial …
- Artesunate protected blood–brain barrier via sphingosine 1 phosphate receptor 1/Phosphatidylinositol 3 kinase pathway after subarachnoid hemorrhage in rats
- Discovery of bifunctional oncogenic target inhibitors against allosteric mitogen-activated protein kinase (MEK1) and Phosphatidylinositol 3–kinase (PI3K)
- … ameliorates rheumatoid arthritis by inactivation of the Phosphatidylinositol 3‐kinase/AKT signaling pathway via Phosphatidylinositol 3‐kinase regulatory subunit 2
- Andrographolide inhibits hypoxia-inducible factor-1 through Phosphatidylinositol 3–kinase/AKT pathway and suppresses breast cancer growth
- Phosphatidylinositol 3–kinase, class 2 beta (PI3KC2β) isoform contributes to neuroblastoma tumorigenesis
- Phosphatidylinositol 3 kinase/protein kinase B is responsible for the protection of paeoniflorin upon H2O2-induced neural progenitor cell injury
- … translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a Phosphatidylinositol 3–kinase/Akt-dependent mechanism
- Promotion of tumor invasion by tumor-associated macrophages: the role of CSF-1-activated Phosphatidylinositol 3 kinase and Src family kinase motility signaling
- Overgrowth syndromes caused by somatic variants in the Phosphatidylinositol 3–kinase/AKT/mammalian target of rapamycin pathway
- … reaction product of red ginseng, attenuates cisplatin-induced acute kidney injury by regulating nuclear factor κB and Phosphatidylinositol 3–kinase/protein kinase B …
- Autophagy promotes escape from Phosphatidylinositol 3‐kinase inhibition in estrogen receptor‐positive breast cancer
- The novel Phosphatidylinositol–3–kinase (PI3K) inhibitor alpelisib effectively inhibits growth of PTEN-haploinsufficient lipoma cells
- Particulate matter 2.5 induces autophagy via inhibition of the Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin kinase signaling pathway in …
- In vitro multifaceted activities of a specific group of novel Phosphatidylinositol 3–kinase inhibitors on hotspot mutant PIK3CA
- The Role of the LY294002-A Non-Selective Inhibitor of Phosphatidylinositol 3–kinase (PI3K) Pathway-in Cell Survival and Proliferation in Cell Line SCC-25
- … effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of Phosphatidylinositol 3–kinase/Akt signaling pathway
- Tanshinone IIA affects autophagy and apoptosis of glioma cells by inhibiting Phosphatidylinositol 3–kinase/Akt/mammalian target of rapamycin signaling pathway
- MicroRNA-31 regulating apoptosis by mediating the Phosphatidylinositol–3 kinase/protein kinase B signaling pathway in treatment of spinal cord injury
- Activation of the Phosphatidylinositol 3–kinase/Akt pathway is involved in lipocalin-2-promoted human pulmonary artery smooth muscle cell proliferation
- Synthesis and biological evaluation of solubilized sulfonamide analogues of the Phosphatidylinositol 3–kinase inhibitor ZSTK474
- Varicella-zoster virus ORF12 protein activates the Phosphatidylinositol 3–kinase/Akt pathway to regulate cell cycle progression
- Phosphatidylinositol 3–kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells
- MiR-338-5p promotes metastasis of colorectal cancer by inhibition of Phosphatidylinositol 3–kinase, catalytic subunit type 3-mediated autophagy pathway
- Signals controlling un‐differentiated states in embryonic stem and cancer cells: Role of the Phosphatidylinositol 3′ kinase pathway
- Curcumin protects mice from coxsackievirus B3-induced myocarditis by inhibiting the Phosphatidylinositol 3 kinase/Akt/nuclear factor-κB pathway
- The Phosphatidylinositol‐3 kinase I inhibitor BKM120 induces cell death in B‐chronic lymphocytic leukemia cells in vitro
- Curcumin inhibits the growth of liver cancer stem cells through the Phosphatidylinositol 3–kinase/protein kinase B/mammalian target of rapamycin signaling …
- Clinical validation of coexisting activating mutations within EGFR, mitogen-activated protein kinase, and Phosphatidylinositol 3–kinase pathways in lung cancers
- MEF2 is a converging hub for histone deacetylase 4 and Phosphatidylinositol 3–kinase/Akt-induced transformation
- Key roles for GRB2-associated-binding protein 1, Phosphatidylinositol–3–kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic …
- Phosphatidylinositol 3–kinase (PI3KCA) oncogene mutation analysis and gene expression profiling in primary breast cancer patients
- The effect of Phosphatidylinositol–3 kinase inhibition on matrix metalloproteinase-9 and reactive oxygen species release from chronic obstructive pulmonary disease …
- Butyrophilin Btn2a2 inhibits TCR activation and Phosphatidylinositol 3–kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes
- Activity of the novel dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against osteosarcoma
- Quercetin suppresses invasion and migration of H-Ras-transformed MCF10A human epithelial cells by inhibiting Phosphatidylinositol 3–kinase
- Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via Phosphatidylinositol 3–kinase and AMP-activated protein kinase
- Eupafolin suppresses prostate cancer by targeting Phosphatidylinositol 3‐kinase‐mediated Akt signaling
- Ceramide limits Phosphatidylinositol–3–kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid
- Inhibition of Phosphatidylinositol 3–kinase (PI3K) signaling synergistically potentiates antitumor efficacy of paclitaxel and overcomes paclitaxel-mediated resistance in …
- Inhibitory effect of idelalisib, a selective Phosphatidylinositol 3–kinase δ inhibitor, on adipogenesis in an in vitro model of Graves’ orbitopathy
- Heterologous Expression, Purification, and Functional Analysis of Plasmodium falciparum Phosphatidylinositol 3′-kinase
- … RNA LINC003121 inhibits proliferation and invasion of thyroid cancer cells by suppression of the Phosphatidylinositol–3–kinase (PI3K)/Akt signaling pathway
- Involvement of Phosphatidylinositol 3–kinase in the regulation of proline catabolism in Arabidopsis thaliana
- p62/SQSTM1 accumulation in squamous cell carcinoma of head and neck predicts sensitivity to Phosphatidylinositol 3–kinase pathway inhibitors
- Metabolic Determinants of Sensitivity to Phosphatidylinositol 3–kinase Pathway Inhibitor in Small-Cell Lung CarcinomaMetabolic Determinants of Sensitivity to PI3K …
- … induces extrinsic and intrinsic apoptosis of ovarian cancer cells via the mitogen-activated protein kinase/Phosphatidylinositol–3–kinase/protein kinase B …
- Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line
- Phosphatidylinositol 3–kinase inhibition restores Ca2+ release defects and prolongs survival in myotubularin-deficient mice
- Galangin induces apoptosis in MCF-7 human breast cancer cells through mitochondrial pathway and Phosphatidylinositol 3–kinase/Akt inhibition
- … growth factor protects the ischemic heart via attenuation of the endoplasmic reticulum stress induced apoptosis by activation of Phosphatidylinositol 3–kinase
- … , induces apoptosis, and suppresses inflammation in rheumatoid arthritis fibroblast‐like synoviocytes by inactivating the Phosphatidylinositol 3 kinase/protein kinase B …
- Baicalein protects rats with diabetic cardiomyopathy against oxidative stress and inflammation injury via Phosphatidylinositol 3–kinase (PI3K)/AKT pathway
- Evaluation of WO2013136076: two crystalline forms of the Phosphatidylinositol 3–kinase-δ inhibitor RV-1729
- … ) that signal via protein kinase A (PKA) cross-talk at insulin receptor substrate 1 (IRS1) to activate the Phosphatidylinositol 3–kinase (PI3K)/AKT pathway
- Discovery of a small molecule agonist of Phosphatidylinositol 3–kinase p110α that reactivates latent HIV-1
- Phosphatidylinositol 3–kinase p110δ isoform regulates CD8+ T cell responses during acute viral and intracellular bacterial infections
- Icaritin requires Phosphatidylinositol 3 kinase (PI3K)/Akt signaling to counteract skeletal muscle atrophy following mechanical unloading
- Phosphatidylinositol 3–kinase (PI3Kα)/AKT axis blockade with taselisib or ipatasertib enhances the efficacy of anti-microtubule drugs in human breast cancer …
- Dual targeting of glioblastoma multiforme with a proteasome inhibitor (Velcade) and a Phosphatidylinositol 3–kinase inhibitor (ZSTK474)
- The ancient Phosphatidylinositol 3–kinase signaling system is a master regulator of energy and carbon metabolism in algae
- Wogonin increases cisplatin sensitivity in ovarian cancer cells through inhibition of the Phosphatidylinositol 3–kinase (PI3K)/AKT pathway
- Synthesis and biological evaluation of sulfonamide analogues of the Phosphatidylinositol 3–kinase inhibitor ZSTK474
- TrkB‐mediated activation of the Phosphatidylinositol‐3‐kinase/Akt cascade reduces the damage inflicted by oxygen–glucose deprivation in area CA 3 of the rat …
- Phosphatidylinositol 3–kinase-γ signaling promotes Campylobacter jejuni–induced colitis through neutrophil recruitment in mice
- Productive entry of foot-and-mouth disease virus via macropinocytosis independent of Phosphatidylinositol 3–kinase
- Randomized phase 1 study of the Phosphatidylinositol 3–kinase δ inhibitor idelalisib in patients with allergic rhinitis
- … the sensitivity of human ovarian cancer cells to radiotherapy-induced apoptosis due to downregulation of the Phosphatidylinositol–3–kinase/Akt/phosphatase and …
- … noncoding RNA HOTAIR promotes endometrial carcinoma cell proliferation by binding to PTEN via the activating Phosphatidylinositol 3–kinase/Akt signaling pathway
- Siglec‐15 regulates osteoclast differentiation by modulating RANKL‐induced Phosphatidylinositol 3‐kinase/Akt and Erk pathways in association with signaling …
- Increased visfatin expression is associated with nuclear factor-kappa B and Phosphatidylinositol 3–kinase in periodontal inflammation
- Increase in mitochondrial biogenesis in neuronal cells by RNS60, a physically-modified saline, via Phosphatidylinositol 3–kinase-mediated upregulation of …
- Anticonvulsant action of a selective Phosphatidylinositol–3–kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish
- Predictive factors for the development of diabetes in cancer patients treated with Phosphatidylinositol 3–kinase inhibitors
- … ) phthalate alters estrous cyclicity and accelerates primordial follicle recruitment potentially via dysregulation of the Phosphatidylinositol 3–kinase signaling pathway in …
- Phase I study of apitolisib (GDC-0980), dual Phosphatidylinositol–3–kinase and mammalian target of rapamycin kinase inhibitor, in patients with advanced solid tumors
- Phosphatidylinositol 3‐kinase–DNA Methyltransferase 1–miR‐1281–Histone Deacetylase 4 Regulatory Axis Mediates Platelet‐Derived Growth Factor–Induced …
- Leptin and neutrophil‐activating peptide 2 promote mesenchymal stem cell senescence through activation of the Phosphatidylinositol 3‐kinase/Akt pathway in patients …
- … hypoxia‐induced hypoxia‐inducible factor‐1α/vascular endothelial growth factor expression via inhibiting Phosphatidylinositol 3‐kinase/Akt/mammalian target protein …
- Activation of the Phosphatidylinositol 3‐kinase pathway plays important roles in reduction of cerebral infarction by cilnidipine
- Enterococcus faecalis infection activates Phosphatidylinositol 3–kinase signaling to block apoptotic cell death in macrophages
- IL-21 Promotes CD4 T Cell Responses by Phosphatidylinositol 3–kinase–Dependent Upregulation of CD86 on B Cells
- Phosphatidylinositol 3–kinase couples localised calcium influx to activation of Akt in central nerve terminals
- Domain analysis reveals striking functional differences between the regulatory subunits of Phosphatidylinositol 3–kinase (PI3K), p85α and p85β
- A randomized, phase 2 trial of docetaxel with or without PX-866, an irreversible oral Phosphatidylinositol 3–kinase inhibitor, in patients with relapsed or metastatic …
- Regulation of the tumor-suppressor function of the class III Phosphatidylinositol 3–kinase complex by ubiquitin and SUMO
- … by isoflurane in neonatal hypoxic brain injury by reducing oxidative stress and activation of Phosphatidylinositol–3–kinase/Akt/mammalian target of rapamycin …
- The Phosphatidylinositol–3–kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis …
- Manipulation of cardiac Phosphatidylinositol 3–kinase (PI3K)/Akt signaling by apoptosis regulator through modulating IAP expression (ARIA) regulates …
- Phosphatidylinositol 3–kinase/Akt signal pathway resists the apoptosis and inflammation in human extravillous trophoblasts induced by Porphyromonas gingivalis
- Inhibition of Phosphatidylinositol 3–kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells
- Class IA Phosphatidylinositol 3–kinase inhibition inhibits cell growth and proliferation in mantle cell lymphoma
- Heterogeneity of Phosphatidylinositol–3–kinase (PI3K)/AKT/mammalian target of rapamycin activation in cancer: is PI3K isoform specificity important?
- The class III Phosphatidylinositol 3–kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes
- Regulation of the target of rapamycin and other Phosphatidylinositol 3–kinase-related kinases by membrane targeting
- Creatine inhibits adipogenesis by downregulating insulin-induced activation of the Phosphatidylinositol 3–kinase signaling pathway
- Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and Phosphatidylinositol 3–kinase/Akt signaling pathways
- Extended treatment with selective Phosphatidylinositol 3‐kinase and m TOR inhibitors has effects on metabolism, growth, behaviour and bone strength
- Carbon monoxide releasing molecule induces endothelial nitric oxide synthase activation through a calcium and Phosphatidylinositol 3–kinase/Akt mechanism
- Klotho deficiency aggravates tacrolimus-induced renal injury via the Phosphatidylinositol 3–kinase-Akt-forkhead box protein O pathway
- … endothelial growth factor on proliferation and migration of porcine trophectoderm cells and their regulation by the Phosphatidylinositol–3–kinase-AKT and mitogen …
- Neurotoxicity of developmental hypothyroxinemia and hypothyroidism in rats: Impairments of long-term potentiation are mediated by Phosphatidylinositol 3–kinase …
- Insulin-stimulated degradation of apolipoprotein B100: roles of class II Phosphatidylinositol–3–kinase and autophagy
- Molecular effects of the Phosphatidylinositol–3–kinase inhibitor NVP-BKM120 on T and B-cell acute lymphoblastic leukaemia
- … IIA protects hippocampal neuronal cells from reactive oxygen species through changes in autophagy and activation of Phosphatidylinositol 3–kinase, protein kinas B …
- Prognostic implications of Phosphatidylinositol 3–kinase/AKT signaling pathway activation in gastric carcinomas
- Activated Phosphatidylinositol 3–kinase/Akt inhibits the transition of endothelial progenitor cells to mesenchymal cells by regulating the forkhead box subgroup O-3a …
- Involvement of Phosphatidylinositol 3–kinase/Akt signaling pathway in β1 integrin-mediated internalization of Staphylococcus aureus by alveolar epithelial cells
- The Phosphatidylinositol 3‐kinase Class III Complex Containing TcVps15 and TcVps34 Participates in Autophagy in Trypanosoma cruzi
- Angiopoietin-2 secretion by endothelial cell exosomes: regulation by the Phosphatidylinositol 3–kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) …
- … angiogenesis and tumor migration by regulating hypoxia-inducible factor 1 (HIF-1α) expression via the Phosphatidylinositol 3–kinase (PI3K)/AKT signaling …
- Platelet CD40L modulates thrombus growth via Phosphatidylinositol 3–kinase β, and not via CD40 and IκB kinase α
- NVP-BEZ235, dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor, prominently enhances radiosensitivity of prostate cancer cell line PC-3
- … attenuates liquid fructose-induced adipose tissue insulin resistance through the insulin receptor substrate-1/Phosphatidylinositol 3–kinase/Akt signaling pathway in …
- Targeting Phosphatidylinositol 3–kinase signaling in acute myelogenous leukemia
- Class IA Phosphatidylinositol 3–kinase isoform p110α mediates vascular remodeling
- Identification of a potent, selective, and efficacious Phosphatidylinositol 3–kinase δ (PI3Kδ) inhibitor for the treatment of immunological disorders
- Phosphatidylinositol‐3‐kinase and Akt are required for RIG‐I‐mediated anti‐viral signalling through cross‐talk with IPS‐1
- Effects of lactic acid bacteria on cardiac apoptosis are mediated by activation of the Phosphatidylinositol–3 kinase/AKT survival-signalling pathway in rats fed a …
- Probing the Phosphatidylinositol 3‐kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low‐grade gliomas
- Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via Phosphatidylinositol–3 kinase
- Herpes simplex virus protein kinases US3 and UL13 modulate VP11/12 phosphorylation, virion packaging, and Phosphatidylinositol 3–kinase/Akt signaling activity
- … -1 Receptor-Mediated Inhibition of A-type K+ Current Induces Sensory Neuronal Hyperexcitability Through the Phosphatidylinositol 3–kinase and Extracellular Signal …
- Phosphatidylinositol 3–kinase mediates β-catenin dysfunction of airway epithelium in a toluene diisocyanate-induced murine asthma model
- A randomized, phase II trial of cetuximab with or without PX-866, an irreversible oral Phosphatidylinositol 3–kinase inhibitor, in patients with relapsed or …
- Echinacea purpurea root extract inhibits TNF release in response to Pam3Csk4 in a Phosphatidylinositol–3–kinase dependent manner
- RP105 engages Phosphatidylinositol 3–kinase p110δ to facilitate the trafficking and secretion of cytokines in macrophages during mycobacterial infection
- Autophagy inhibition enhances colorectal cancer apoptosis induced by dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor NVP …
- Phosphatidylinositol 3–kinase: a link between inflammation and pancreatic cancer
- Discovery and optimization of 2-amino-4-methylquinazoline derivatives as highly potent Phosphatidylinositol 3–kinase inhibitors for cancer treatment
- Kaempferol promotes primordial follicle activation through the Phosphatidylinositol 3‐kinase/protein kinase B signaling pathway and reduces DNA fragmentation of …
- … attenuates H2O2-induced oxidant stress in human trabecular meshwork cells (HTMCs) via the Phosphatidylinositol 3–kinase (PI3K)/serine/threonine kinase …
- … can be used as the single antioxidant in the in vitro culture medium, stimulating sheep secondary follicle development through the Phosphatidylinositol 3–kinase …
- Role of Phosphatidylinositol–3–kinase (PI3K) and the mammalian target of rapamycin (mTOR) signalling pathways in porcine reproductive and respiratory syndrome …
- Synergistic therapeutic effect of cisplatin and Phosphatidylinositol 3–kinase (PI3K) inhibitors in cancer growth and metastasis of Brca1 mutant tumors
- Recombinant human erythropoietin preconditioning attenuates liver ischemia reperfusion injury through the Phosphatidylinositol–3 kinase/AKT/endothelial nitric oxide …
- Psoralen and ultraviolet a light treatment directly affects Phosphatidylinositol 3–kinase signal transduction by altering plasma membrane packing
- … the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of Phosphatidylinositol 3‐kinase/AKT signalling and …
- Everolimus reverses palbociclib resistance in ER+ human breast cancer cells by inhibiting Phosphatidylinositol 3–kinase (PI3K)/Akt/mammalian target of …
- Imatinib mesilate-induced Phosphatidylinositol 3–kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol …
- Activation of Phosphatidylinositol 3–kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl
- Genetic diversity of the Plasmodium vivax Phosphatidylinositol 3–kinase gene in two regions of the China-Myanmar border
- Phosphatidylinositol 3–kinase dependent upregulation of the epidermal growth factor receptor upon Flotillin-1 depletion in breast cancer cells
- Four major factors regulate Phosphatidylinositol 3–kinase signaling pathway in cancers induced by infection of human papillomaviruses
- Role of Phosphatidylinositol 3–kinase (PI3K) and Akt1 kinase in porcine reproductive and respiratory syndrome virus (PRRSV) replication
- Distribution of the Phosphatidylinositol 3–kinase inhibitors pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models—assessment by …
- Autophagy-related (ATG) 11, ATG9 and the Phosphatidylinositol 3–kinase control ATG2-mediated formation of autophagosomes in Arabidopsis
- A novel Phosphatidylinositol 3–kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the …
- Alleviation of acute lung injury in rats with sepsis by resveratrol via the Phosphatidylinositol 3–kinase/nuclear factor-erythroid 2 related factor 2/heme …
- LY294002 inhibits the malignant phenotype of osteosarcoma cells by modulating the Phosphatidylinositol 3‑kinase/Akt/fatty acid synthase signaling pathway …
- Neprilysin facilitates adipogenesis through potentiation of the Phosphatidylinositol 3–kinase (PI3K) signaling pathway
- Heat stress alters ovarian insulin-mediated Phosphatidylinositol–3 kinase and steroidogenic signaling in gilt ovaries
- Inhibition of Phosphatidylinositol 3–kinase/AKT signaling by NVP-BKM120 promotes ABT-737–induced toxicity in a caspase-dependent manner through mitochondrial …
- Programmed Death-1 Inhibition of Phosphatidylinositol 3–kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4+ T Cell Proliferation
- Clinical development of Phosphatidylinositol 3–kinase inhibitors for non-Hodgkin lymphoma
- Anti-amyloidogenic effects of ID1201, the ethanolic extract of the fruits of Melia toosendan, through activation of the Phosphatidylinositol 3–kinase/Akt pathway
- Phosphatidylinositol 3‑kinase‑mediated HO‑1/CO represses Fis1 levels and alleviates lipopolysaccharide‑induced oxidative injury in alveolar macrophages
- c-Abl-dependent molecular circuitry involving Smad5 and Phosphatidylinositol 3–kinase regulates bone morphogenetic protein-2-induced osteogenesis
- A randomized, phase 2 trial of docetaxel with or without PX-866, an irreversible oral Phosphatidylinositol 3–kinase inhibitor, in patients with relapsed or …
- Molecular alterations of Ras‐Raf‐mitogen‐activated protein kinase and Phosphatidylinositol 3‐kinase‐Akt signaling pathways in colorectal cancers from a tertiary …
- Early activation of Phosphatidylinositol 3–kinase after ischemic stroke reduces infarct volume and improves long-term behavior
- Type II cGMP‑dependent protein kinase inhibits epidermal growth factor‑induced Phosphatidylinositol‑3‑kinase/Akt signal transduction in gastric cancer cells
- … against corticosterone-induced neuron injuries via restoring extracellular signal-regulated kinase 1/2 and Phosphatidylinositol–3 kinase/protein kinase B …
- Phosphatidylinositol 3–kinase–independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice
- Upregulation of Phosphatidylinositol 3–kinase (PI3K) Enhances Ethylene Biosynthesis and Accelerates Flower Senescence in Transgenic Nicotiana tabacum L.
- Epidermal growth factor receptor, Phosphatidylinositol–3–kinase catalytic subunit/PTEN, and KRAS/NRAS/BRAF in primary resected esophageal adenocarcinomas …
- Strategically Timing Inhibition of Phosphatidylinositol 3–kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha–Positive, PIK3CA-Mutant Breast …
- High expression of proline-rich tyrosine kinase2 is associated with poor survival of hepatocellular carcinoma via regulating Phosphatidylinositol 3–kinase/AKT pathway
- Paclitaxel resistance in MCF-7/PTX cells is reversed by paeonol through suppression of the SET/Phosphatidylinositol 3–kinase/Akt pathway
- A phase II study of the selective Phosphatidylinositol 3–kinase delta (PI3Kδ) inhibitor idelalisib (GS-1101) in combination with rituximab (R) in treatment-naive patients …
- Inactivation of the Phosphatidylinositol 3‐kinase/Akt Pathway is Involved in BMP9‐mediated Tumor‐suppressive Effects in Gastric Cancer Cells
- Pterostilbene protects against UVB-induced photo-damage through a Phosphatidylinositol–3–kinase-dependent Nrf2/ARE pathway in human keratinocytes
- Activation of Phosphatidylinositol–3 kinase, AMP-activated kinase and Akt substrate-160 kDa by trans-10, cis-12 conjugated linoleic acid mediates skeletal muscle …
- … and polychlorinated biphenyls increase resistance of hepatocellular carcinoma cells to cisplatin through the Phosphatidylinositol 3–kinase/protein kinase B pathway
- Signal transducer and activator of transcription 3 and the Phosphatidylinositol 3‐kinase regulatory subunits p55α and p50α regulate autophagy in vivo
- Kaposi’s sarcoma-associated herpesvirus nonstructural membrane protein pK15 recruits the class II Phosphatidylinositol 3–kinase PI3K-C2α to activate productive viral …
- Strong inhibition of neutrophil–sperm interaction in cattle by selective Phosphatidylinositol 3–kinase inhibitors
- Insights into the pathological mechanisms of p85α mutations using a yeast-based Phosphatidylinositol 3–kinase model
- Ras, Rac1, and Phosphatidylinositol–3–kinase (PI3K) signaling in nitric oxide induced endothelial cell migration
- Ghrelin augments murine T-cell proliferation by activation of the Phosphatidylinositol–3–kinase, extracellular signal-regulated kinase and protein kinase C …
- Phosphatidylinositol–3–kinase inhibitor induces chemosensitivity to a novel derivative of doxorubicin, AD198 chemotherapy in human bladder cancer cells in …
- Evaluation of Phosphatidylinositol–3–kinase catalytic subunit (PIK3CA) and epidermal growth factor receptor (EGFR) gene mutations in pancreaticobiliary …
- … pigment epithelium/choroid organ cultures: p38, nuclear factor kappaB, and the vascular endothelial growth factor receptor-2/Phosphatidylinositol 3 kinase …
- Lindersin B from Lindernia crustacea induces neuritogenesis by activation of tyrosine kinase A/Phosphatidylinositol 3 kinase/extracellular signal-regulated kinase …
- An essential role for Phosphatidylinositol 3‐kinase in the inhibition of phagosomal maturation, intracellular survival and virulence in Candida glabrata
- Macrophage migration inhibitory factor induces phosphorylation of Mdm2 mediated by Phosphatidylinositol 3–kinase/Akt kinase: role of this pathway in decidual cell …
- Effects of Tyroserleutide on Phosphatidylinositol 3′-kinase/AKT pathway in human hepatocellular carcinoma cell
- Phosphatidylinositol–3–kinase as a putative target for anticancer action of clotrimazole
- Rationale for using irreversible epidermal growth factor receptor inhibitors in combination with Phosphatidylinositol 3–kinase inhibitors for advanced head and neck …
- Post-surgical inhibition of Phosphatidylinositol 3–kinase attenuates the plantar incision-induced postoperative pain behavior via spinal Akt activation in male …
- Deficiency of Phosphatidylinositol 3–kinase δ signaling leads to diminished numbers of regulatory T cells and increased neutrophil activity resulting in mortality due to …
- Prognostic significance of constitutive Phosphatidylinositol 3–kinase/Akt and mitogen-activated protein kinase phosphorylation in acute myeloid leukemia
- Involvement of Phosphatidylinositol–3 kinase/Akt/mammalian target of rapamycin/peroxisome proliferator-activated receptor γ pathway for induction and maintenance …
- A genomewide overexpression screen identifies genes involved in the Phosphatidylinositol 3–kinase pathway in the human protozoan parasite Entamoeba histolytica
- Protection of carboxymethylated chitosan on chondrocytes from nitric oxide-induced apoptosis by regulating Phosphatidylinositol 3–kinase/Akt signaling pathway
- Effect of 2-arachidonoylglycerol on myosin light chain phosphorylation and platelet activation: The role of Phosphatidylinositol 3 kinase/AKT pathway
- … Receptor–Mediated Double-Stranded RNA Internalization Is Independent of Innate Antiviral Signaling and Does Not Require Phosphatidylinositol 3–kinase Activity
- … -estradiol impedes Bax-involved mitochondrial apoptosis of retinal nerve cells induced by oxidative damage via the Phosphatidylinositol 3–kinase/Akt signal pathway
- Isotype-specific inhibition of the Phosphatidylinositol–3–kinase pathway in hematologic malignancies
- A basal tone of 2-arachidonoylglycerol contributes to early oligodendrocyte progenitor proliferation by activating Phosphatidylinositol 3–kinase (PI3K)/AKT and the …
- … cell factor promotes in vitro ovarian follicle development in the domestic cat by upregulating c-kit mRNA expression and stimulating the Phosphatidylinositol 3–kinase …
- Glutamine enhances the hypoglycemic effect of insulin in L6 cells via Phosphatidylinositol–3–kinase (PI3K)/protein kinase B (AKT)/glucose transporter 4 …
- Phosphatidylinositol 3–kinase/AKT pathway inhibition by doxazosin promotes glioblastoma cells death, upregulation of p53 and triggers low neurotoxicity
- Insulin receptor substrate 1, the hub linking follicle-stimulating hormone to Phosphatidylinositol 3–kinase activation
- Epithelial cells augment barrier function via activation of the Toll-like receptor 2/Phosphatidylinositol 3–kinase pathway upon recognition of Salmonella enterica …
- Targeting Phosphatidylinositol 3–kinase Signaling Pathway for Therapeutic Enhancement of Vascular-Targeted Photodynamic TherapyTargeting PI3K Pathway for …
- Mechanism of hyperhomocysteinemia-induced vascular endothelium dysfunction–Possible dysregulation of Phosphatidylinositol–3–kinase and its downstream …
- Insulin-like growth factor-1 (IGF-1) promotes primordial follicle growth and reduces DNA fragmentation through the Phosphatidylinositol 3–kinase/protein kinase B …
- Combined Inhibition of Both p110α and p110β Isoforms of Phosphatidylinositol 3–kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER+ Breast …
- … promotes in vitro activation of ovine primordial follicles by reducing DNA damage and enhancing granulosa cell proliferation via Phosphatidylinositol 3‐kinase …
- … transition and cancer stem-like cell properties via the vascular endothelial growth factor (VEGF)/Phosphatidylinositol 3–kinase (PI3K)/Akt/mechanistic target of …
- Annexin A5 inhibits diffuse large B-cell lymphoma cell invasion and chemoresistance through Phosphatidylinositol 3–kinase signaling
- Insulin receptor substrate 2-mediated Phosphatidylinositol 3–kinase signaling selectively inhibits glycogen synthase kinase 3β to regulate aerobic glycolysis
- Hijacking Dlg1 for oncogenic Phosphatidylinositol 3–kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins
- Antitumor activity and pharmacologic characterization of the depsipeptide analog as a novel histone deacetylase/Phosphatidylinositol 3‐kinase dual inhibitor
- A Precision B Cell–Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3–kinase Pathway Dysregulation
- Phosphatidylinositol–3 kinase-dependent translational regulation of Id1 involves the PPM1G phosphatase
- A humanized yeast-based toolkit for monitoring Phosphatidylinositol 3–kinase activity at both single cell and population levels
- Association of phosphatase and tensin homolog low and Phosphatidylinositol 3–kinase catalytic subunit alpha gene mutations on outcome in human …
- … GAS5) suppresses esophageal squamous cell carcinoma cell proliferation and migration by inactivating Phosphatidylinositol 3–kinase (PI3K)/AKT/mammalian …
- … Obstruction-Induced Renal Lymphangiogenesis Through CC Motif Chemokine Receptor 2–Dependent Phosphatidylinositol 3–kinase-Akt–Mechanistic Target …
- Suppression of Phosphatidylinositol 3–kinase/Akt signaling attenuates hypoxia-induced pulmonary hypertension through the downregulation of lysyl oxidase
- Association of Phosphatidylinositol 3–kinase (PI3K) pathway activation with increased immune checkpoint expression in colorectal cancer (CRC) patients.
- Chimeric nanoparticle: a platform for simultaneous targeting of Phosphatidylinositol–3–kinase signaling and damaging DNA in cancer cells
- The effects of glucagon-like peptide-2 on the tight junction and barrier function in IPEC-J2 cells through Phosphatidylinositol 3–kinase–protein kinase B …
- A virtual screen identified C96 as a novel inhibitor of Phosphatidylinositol 3–kinase that displays potent preclinical activity against multiple myeloma in vitro …
- … -II receptor stimulation of cardiac L-type Ca2+ channels requires the βγ subunits of Gi/o-protein and Phosphatidylinositol 3–kinase-dependent protein kinase C …
- Phosphatidylinositol–3–kinase and protein kinase C are involved in the pro-cognitive and anti-anxiety effects of phytohormone abscisic acid in rats
- … , synthesis and biological evaluation of 2, 3-dihydroimidazo [1, 2-c] quinazoline derivatives as novel Phosphatidylinositol 3–kinase and histone deacetylase …
- Phosphatidylinositol 3–kinase is involved in Toll-like receptor 4-mediated BST-2/tetherin regulation
- Roles of transforming growth factor-β and Phosphatidylinositol 3–kinase isoforms in integrin β1-mediated bio-behaviors of mouse lung telocytes
- Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III Phosphatidylinositol 3–kinase
- Relaxin confers cytotrophoblast protection from hypoxia-reoxygenation injury through the Phosphatidylinositol 3–kinase-Akt/protein kinase B cell survival pathway
- … against growth factor-deprived apoptosis on olfactory bulb neural progenitor cells through the brain-derived neurotrophic factor–Phosphatidylinositol 3′-kinase/Akt …
- Novel Phosphatidylinositol 3–kinase inhibitor BKM120 enhances the sensitivity of multiple myeloma to bortezomib and overcomes resistance
- The Vacuolar Protein Sorting-38 Subunit of the Arabidopsis Phosphatidylinositol–3–kinase Complex Plays Critical Roles in Autophagy, Endosome Sorting …
- Upregulation of myelin gene expression by a physically-modified saline via Phosphatidylinositol 3–kinase-mediated activation of CREB: implications for …
- DW09849, a selective Phosphatidylinositol 3–kinase (PI3K) inhibitor, prevents PI3K signaling and preferentially inhibits proliferation of cells containing the oncogenic …
- Volatile inhibitors of Phosphatidylinositol–3–kinase (PI3K) pathway: anticancer potential of aroma compounds of plant essential oils
- Phosphatidylinositol 3–kinase promotes V-ATPase activation and vacuolar acidification and delays methyl jasmonate-induced leaf senescence
- Tumor Phosphatidylinositol 3–kinase signaling in therapy resistance and metastatic dissemination of rectal cancer: opportunities for signaling-adapted therapies
- miR-362-5p inhibits proliferation and migration of neuroblastoma cells by targeting Phosphatidylinositol 3–kinase-C2β
- Theoretical calculations, DNA interaction, topoisomerase I and Phosphatidylinositol–3–kinase studies of water soluble mixed-ligand nickel (II) complexes
- … Regulate Intestinal UDP-Glucuronosyltransferase 1A1 Partially Through Toll-Like Receptor 4/Mitogen-Activated Protein kinase/Phosphatidylinositol 3–kinase …
- … effect of colony stimulating factor 2 on porcine trophectoderm cells is mediated by activation of Phosphatidylinositol 3–kinase and extracellular signal …
- The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of Phosphatidylinositol 3–kinase
- Prognostic implications of the Phosphatidylinositol 3–kinase/Akt signaling pathway in oral squamous cell carcinoma: overexpression of p-mTOR indicates an …
- Expression of Phosphatidylinositol–3 kinase and effects of inhibitor Wortmannin on expression of tumor necrosis factor-α in severe acute pancreatitis …
- Deciphering the role of Phosphatidylinositol 3–kinase mutations in human epidermal growth factor receptor 2-positive breast cancer.
- Girinimbine inhibits the proliferation of human ovarian cancer cells in vitro via the Phosphatidylinositol–3–kinase (PI3K)/akt and the mammalian target of …
- Dual inhibition of Phosphatidylinositol 3′-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach for mucinous …
- Endosomal Phosphatidylinositol 3–kinase is essential for canonical GPCR signaling
- High-throughput small interfering RNA screening identifies Phosphatidylinositol 3–kinase class II alpha as important for production of human cytomegalovirus virions
- Role of Phosphatidylinositol–3 kinase pathway in NMDA preconditioning: different mechanisms for seizures and hippocampal neuronal degeneration induced by …
- Par3 integrates Tiam1 and Phosphatidylinositol 3–kinase signaling to change apical membrane identity
- … 6 gene promotes aggressiveness of esophageal carcinoma cells by increasing intracellular levels of zinc, activating Phosphatidylinositol 3–kinase signaling, and up …
- Extracellular signal-regulated kinase mitogen-activated protein kinase and Phosphatidylinositol 3–kinase/Akt signaling are required for lipopolysaccharide-mediated …
- Anti-tumor activity of dual inhibition of Phosphatidylinositol 3–kinase and MDM2 against clear cell ovarian carcinoma
- Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires Phosphatidylinositol 3–kinase γ in rodent and human β-cells
- Fisetin targets Phosphatidylinositol–3–kinase and induces apoptosis of human B lymphoma Raji cells
- Insights into insulin-mediated regulation of CYP2E1: miR-132/-212 targeting of CYP2E1 and role of Phosphatidylinositol 3–kinase, Akt (protein kinase B), mammalian …
- Ugi reaction-derived α-acyl aminocarboxamides bind to Phosphatidylinositol 3–kinase-related kinases, inhibit HSF1-dependent heat shock response, and induce …
- Expression and clinical significance of the Phosphatidylinositol 3‑kinase/protein kinase B signal transduction pathway in non‑small cell lung carcinoma
- Ras-related C3 botulinum toxin substrate (Rac) and Src family kinases (SFK) are proximal and essential for Phosphatidylinositol 3–kinase (PI3K) activation in …
- Phosphatidylinositol 3–kinase γ is required for the development of experimental cerebral malaria
- MicroRNA-21 promotes phosphatase gene and protein kinase B/Phosphatidylinositol 3–kinase expression in colorectal cancer
- Human ATP-binding cassette transporter ABCG2 confers resistance to CUDC-907, a dual inhibitor of histone deacetylase and Phosphatidylinositol 3–kinase
- … inhibition of Purkinje neuron P‐type Ca2+ channels in vitro induces neuronal hyperexcitability through the Phosphatidylinositol 3‐kinase‐dependent protein kinase C …
- Pingchuanning decoction attenuates airway inflammation by suppressing autophagy via Phosphatidylinositol 3‐kinase/protein kinase B/mammalian target of …
- Positron emission tomographic monitoring of dual Phosphatidylinositol–3–kinase and mTOR inhibition in anaplastic large cell lymphoma
- … -induced focal segmental glomerulosclerosis by inhibiting the hypoxia-inducible factor-1α expression through Phosphatidylinositol 3–kinase/protein kinase B pathway
- Tanshinone I inhibits vascular smooth muscle cell proliferation by targeting insulin-like growth factor-1 receptor/Phosphatidylinositol–3–kinase signaling pathway
- Identification and optimisation of a 4′, 5-bisthiazole series of selective Phosphatidylinositol–3 kinase alpha inhibitors
- Role of protein kinase A and class II Phosphatidylinositol 3–kinase C2β in the downregulation of KCa3. 1 channel synthesis and membrane surface expression by lyso …
- Pharmacokinetics of intravenous pan-class I Phosphatidylinositol 3–kinase (PI3K) inhibitor [14C] copanlisib (BAY 80-6946) in a mass balance study in healthy …
- A randomized, phase II trial of cetuximab with or without PX-866, an irreversible oral Phosphatidylinositol 3–kinase inhibitor, in patients with metastatic colorectal …
- NKG2D induces Mcl-1 expression and mediates survival of CD8 memory T cell precursors via Phosphatidylinositol 3–kinase
- Induction of H2AX phosphorylation in tumor cells by gossypol acetic acid is mediated by Phosphatidylinositol 3–kinase (PI3K) family
- Phosphatidylinositol 3–kinase function at very early symbiont perception: a local nodulation control under stress conditions?
- 2-Methoxyestradiol inhibits hypoxia-induced scleroderma fibroblast collagen synthesis by Phosphatidylinositol 3–kinase/Akt/mTOR signalling
- MiR‐193a‐3p and miR‐224 mediate renal cell carcinoma progression by targeting alpha‐2, 3‐sialyltransferase IV and the Phosphatidylinositol 3 kinase/Akt pathway
- Role of ghrelin-induced Phosphatidylinositol 3–kinase activation in modulation of gastric mucosal inflammatory responses to Helicobacter pylori
- Effect of the dual Phosphatidylinositol 3‑kinase/mammalian target of rapamycin inhibitor NVP‑BEZ235 against human Merkel cell carcinoma MKL‑1 cells
- … IIA promotes non‑amyloidogenic processing of amyloid precursor protein in platelets via estrogen receptor signaling to Phosphatidylinositol 3–kinase/Akt
- Phosphatidylinositol 3–kinase (PI3K) signalling regulates insulin-like-growth factor binding protein-2 (IGFBP-2) production in human adipocytes
- The association of leukocyte Phosphatidylinositol 3–kinase delta overexpression with gestational diabetes mellitus (GDM)
- … isoflavone, induces apoptosis of estrogen receptor-positive MG-63 osteosarcoma cells via the Phosphatidylinositol 3–kinase (PI3K)/AKT/Mammalian target of …
- Gene expression profiling in mouse embryonic stem cells reveals glycogen synthase kinase–3-dependent targets of Phosphatidylinositol 3–kinase and Wnt/β …
- Effects of NVP‑BEZ235, a dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor, on HTLV-1-infected T-cell lines
- … Inhibits Transforming Growth Factor Beta 1 Induced Myofibroblast Differentiation via the Phosphorylated-Phosphatidylinositol 3–kinase Mammalian Target of …
- The overlap between regeneration and fibrosis in injured skeletal muscle is regulated by Phosphatidylinositol 3–kinase/Akt signaling pathway-A bioinformatic analysis …
- Initial testing (stage 1) of the Phosphatidylinositol 3′ kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program
- Phosphatidylinositol 3‐kinase is an Upstream Regulator of the Phosphodiesterase 3B Pathway of Leptin Signalling that may not Involve Activation of Akt in the Rat …
- Dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 synergizes with chloroquine to induce apoptosis in embryonal …
- Retraction: A005, a novel inhibitor of Phosphatidylinositol 3–kinase/mammalian target of rapamycin, prevents osteosarcoma-induced osteolysis.
- The Phosphatidylinositol 3–kinase p110α/PTEN Signaling Pathway Is Crucial for HIV-1 Entry
- Development of novel PET probes targeting Phosphatidylinositol 3–kinase (PI3K) in tumors
- Double-stranded RNA induces cathelicidin expression in the intestinal epithelial cells through Phosphatidylinositol 3–kinase-protein kinase Cζ-Sp1 pathway and …
- Rho kinase inhibitor Y-27632 promotes neuronal differentiation in mouse embryonic stem cells via Phosphatidylinositol 3–kinase
- Effects of Phosphatidylinositol–3 kinase/protein kinase b/bone morphogenetic protein-15 pathway on the follicular development in the mammalian ovary
- IPD-196, a novel Phosphatidylinositol 3–kinase inhibitor with potent anticancer activity against hepatocellular carcinoma
- Roles of Phosphatidylinositol 3–kinase regulatory subunit alpha, activator protein-1, and programmed cell death 4 in diagnosis of papillary thyroid carcinoma
- RhoA/Phosphatidylinositol 3–kinase/Protein kinase B/Mitogen-Activated Protein kinase Signaling after Growth Arrest–Specific Protein 6/Mer Receptor Tyrosine …
- Inhibition of Phosphatidylinositol–3–kinase by the furanosesquiterpenoid hibiscone C
- Blocking the Phosphatidylinositol 3–kinase pathway inhibits neuregulin-1-mediated rescue of neurotoxicity induced by Aβ1–42
- Phosphatidylinositol 3–kinase regulatory subunit 1 and phosphatase and tensin homolog as therapeutic targets in breast cancer
- … by whole exome sequencing of endometrial hyperplasia and carcinoma in one patient: abnormalities of polymerase epsilon and the Phosphatidylinositol‐3 kinase …
- The Phosphatidylinositol 3–kinase (PI3K) isoform dependence of tumor formation is determined by the genetic mode of PI3K pathway activation rather than by tissue …
- Diazoxide protects L6 skeletal myoblasts from H2O2-induced apoptosis via the Phosphatidylinositol–3 kinase/Akt pathway
- Increased expression of Phosphatidylinositol 3–kinase p110α and gene amplification of PIK3CA in nasopharyngeal carcinoma
- Phosphatidylinositol 3–kinase CB association with preoperative radiotherapy response in rectal adenocarcinoma
- Final results of a phase I study of idelalisib, a selective inhibitor of Phosphatidylinositol 3–kinase P110δ (PI3Kδ), in patients with relapsed or refractory mantle cell …
- Suppression of Nkx3. 2 by Phosphatidylinositol–3–kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy
- … of emodin on amyloid-β25–35-induced neurotoxicity in aβpp/ps1 mice and pc12 cells through activation of the class iii Phosphatidylinositol 3–kinase/beclin-1/b-cell …
- Progressive obesity alters ovarian insulin, Phosphatidylinositol–3 kinase, and chemical metabolism signaling pathways and potentiates ovotoxicity induced by …
- Ciliary neurotrophic factor (CNTF) promotes skeletal muscle progenitor cell (MPC) viability via the Phosphatidylinositol 3‐kinase–Akt pathway
- … of a robust flow cytometry-based pharmacodynamic assay to detect phospho-protein signals for Phosphatidylinositol 3–kinase inhibitors in multiple myeloma
- Potent Phosphatidylinositol 3–kinase inhibitors and their biology
- … -chain amino acids and carbohydrate in men does not preferentially augment resistance exercise–induced increases in Phosphatidylinositol 3 kinase/protein kinase B …
- Idelalisib: the first-in-class Phosphatidylinositol 3–kinase inhibitor for relapsed CLL, SLL, and indolent NHL
- … cell wall integrity pathway signals from recycling endosomes upon elimination of Phosphatidylinositol (4, 5)-bisphosphate by mammalian Phosphatidylinositol 3–kinase
- … growth factor antagonist NK4 inhibits indoleamine-2, 3-dioxygenase expression via the c-Met-Phosphatidylinositol 3–kinase-AKT signaling pathway
- Phosphatidylinositol 3–kinase p110δ expression in Merkel cell carcinoma
- … specific membrane antigen knockdown impairs the tumorigenicity of LNCaP prostate cancer cells by inhibiting the Phosphatidylinositol 3–kinase/Akt signaling pathway
- Activation of the Phosphatidylinositol 3–kinase/Akt pathway by viral interferon regulatory factor 2 of Kaposi’s sarcoma-associated herpesvirus
- Tumor necrosis factor–related apoptosis-inducing ligand promotes microvascular endothelial cell hyperpermeability through Phosphatidylinositol 3–kinase pathway
- Dual inhibition of Phosphatidylinositol 3–kinase/mammalian target of rapamycin and mitogen activated protein kinase pathways in non-Hodgkin lymphoma
- Lactoferrin induces tropoelastin expression by activating the lipoprotein receptor‐related protein 1‐mediated Phosphatidylinositol 3‐kinase/Akt pathway in human …
- Overcoming Phosphatidylinositol 3–kinase PI3K) Activation in Breast Cancer: Emerging PI3K Inhibitors.
- Phosphatidylinositol 3–kinase mediates the ability of retinol to decrease colorectal cancer cell invasion
- … of vascular endothelial growth factor receptor 2 and downstream pathways of receptor tyrosine kinases involving Phosphatidylinositol 3–kinase/Akt/mammalian target …
- G-protein coupled receptor 34 activates Erk and Phosphatidylinositol 3–kinase/Akt pathways and functions as alternative pathway to mediate p185Bcr–Abl-induced …
- Synthesis of pelorol and its analogs and their inhibitory effects on Phosphatidylinositol 3–kinase
- Basal expression of insulin‐like growth factor 1 receptor determines intrinsic resistance of cancer cells to a Phosphatidylinositol 3‐kinase inhibitor ZSTK474
- Avian reovirus σA and σNS proteins activate the Phosphatidylinositol 3–kinase-dependent Akt signalling pathway
- MicroRNA-126 regulates the Phosphatidylinositol–3 kinase (PI3K)/protein kinase B (AKT) pathway in SLK cells in vitro and the expression of its pathway …
- Pterostilbene attenuates myocardial ischemia‑reperfusion injury via the Phosphatidylinositol 3‘‑kinase‑protein kinase B signaling pathway
- Changes in Phosphatidylinositol 3–kinase 55 kDa gamma expression and subcellular localization may be caspase 6 dependent in paraquat-induced SH-SY5Y …
- Characterisation of the Phosphatidylinositol 3–kinase pathway in non-small cell lung cancer cells isolated from pleural effusions
- Overexpression of ATP-binding cassette subfamily G member 2 confers resistance to Phosphatidylinositol 3–kinase inhibitor PF-4989216 in cancer cells
- … type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the Phosphatidylinositol 3–kinase and c-Src …
- Mechanisms by which the N-terminal 24 amino acids of the p55 regulatory subunit of Phosphatidylinositol 3–kinase affect endotoxin-induced cytokine release …
- … upregulates vascular endothelial growth factor and protects against kainic acid-induced neuronal cell death: Involvement of the Phosphatidylinositol–3 kinase/akt …
- A Phosphatidylinositol 3–kinase inhibitor strongly suppressed pulmonary vascular remodeling of allergic vasculitis in a murine model
- Eplerenone pretreatment protects the myocardium against ischaemia/reperfusion injury through the Phosphatidylinositol 3–kinase/Akt-dependent pathway in diabetic …
- … herbal medicine, promotes neurite outgrowth in PC12 cells through the activation of extracellular signal regulated kinase 1/2 and Phosphatidylinositol 3–kinase/Akt
- … increases the activity of excitatory amino acid transporter type 3 expressed in Xenopus oocytes: The involvement of protein kinase C and Phosphatidylinositol 3–kinase
- Insulin‐Like Growth Factor—Phosphatidylinositol 3 kinase Signaling in Canine Cortisol‐Secreting Adrenocortical Tumors
- mRNA expression of programmed cell death ligand 1 and components of the Phosphatidylinositol 3–kinase/AKT/phosphatase and tensin homolog pathway in …
- … activity of tetradecyl 2, 3-dihydroxybenzoate is mediated through the insulin-like growth factor 1 receptor/Phosphatidylinositol 3 kinase/mitogen-activated protein …
- … improves cognitive functions and alleviates inflammation and nuclear damage by regulating Phosphatidylinositol 3 kinase (PI3K)/phosphoinositol-dependent …
- Effects of chromium-loaded chitosan nanoparticles on glucose transporter 4, relevant mRNA, and proteins of Phosphatidylinositol 3–kinase, Akt2-kinase, and AMP …
- Synthesis and Evaluation of Imidazo[1,2‐a]pyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3‐kinase Inhibitors
- Phosphatidylinositol 3–kinase inhibition induces vasodilator effect of sevoflurane via reduction of Rho kinase activity
- Pharmacologic characterization of SHR8443, a novel dual inhibitor of Phosphatidylinositol 3–kinase and mammalian target of rapamycin
- Iloprost supports early development of in vitro-produced porcine embryos through activation of the Phosphatidylinositol 3–kinase/AKT signalling pathway
- Profiling of Phosphatidylinositol 3–kinase (PI3K) proteins in insulin signaling pathway
- Phosphatidylinositol 3–kinase/Akt and MEK/ERK signaling pathways facilitate sapovirus trafficking and late endosomal acidification for viral uncoating in LLC-PK cells
- JTC‑801 inhibits the proliferation and metastasis of the Hep G2 hepatoblastoma cell line by regulating the Phosphatidylinositol 3‑kinase/protein kinase B …
- Synergistic growth inhibition by acyclic retinoid and Phosphatidylinositol 3–kinase inhibitor in human hepatoma cells
- Phosphatidylinositol 3–kinase-associated protein (PI3KAP)/XB130 crosslinks actin filaments through its actin binding and multimerization properties in vitro …
- Intracellular transactivation of epidermal growth factor receptor by α1A-adrenoceptor is mediated by Phosphatidylinositol 3–kinase independently of activation of …
- Vascular endothelial growth factor induces multidrug resistance-associated protein 1 overexpression through Phosphatidylinositol–3–kinase/protein kinase B signaling …
- Identification of the binding sites on Rab5 and p110beta Phosphatidylinositol 3–kinase
- Terlipressin protects intestinal epithelial cells against oxygen-glucose deprivation/re-oxygenation injury via the Phosphatidylinositol 3–kinase pathway
- From Discovery to Market Readiness: The Research and Development of the β-Sparing Phosphatidylinositol 3–kinase Inhibitor Taselisib
- The p110δ isoforme of Phosphatidylinositol 3–kinase plays an important role in host defense against chlamydial lung infection through influencing CD4+ T-cell …
- The role of Phosphatidylinositol 3 kinase (PI3K) and Cycloxygenase-2 (COX2) in carcinogenesis of colorectal polyps
- Phosphatidylinositol 3–kinase p110α mediates phosphorylation of AMP-activated protein kinase in myoblasts
- Steroid-induced oocyte maturation in Indian shad Tenualosa ilisha (Hamilton, 1822) is dependent on Phosphatidylinositol 3 kinase but not MAP kinase activation
- Buparlisib: Phosphatidylinositol 3–kinase alpha inhibitor oncolytic
- 19F-NMR-based determination of the absorption, metabolism and excretion of the oral Phosphatidylinositol–3–kinase (PI3K) delta inhibitor leniolisib (CDZ173) in …
- Phosphatidylinositol 3–kinase and protein kinase c signaling pathways are involved in stromal cell–derived factor-1α–mediated transmigration of stem cells from apical …
- A phase Ib study of prexasertib, a checkpoint kinase (CHK1) inhibitor, and LY3023414, a dual inhibitor of class I Phosphatidylinositol 3–kinase (PI3K) and the …
- A7. 07 Phosphatidylinositol 3–kinase delta pathway a novel therapeutic target for sjoegren’s syndrome
- Phosphatidylinositol 3–kinase p110δ drives intestinal fibrosis in SHIP deficiency
- Ser81 Survivin Induced Protein kinase A (PKA)-dependent Phosphatidylinositol 3–kinase (PI3K) Activity
- PIPA: A phase Ib study of β-isoform sparing Phosphatidylinositol 3–kinase (PI3K) inhibitor taselisib (T) plus palbociclib (P) and fulvestrant (FUL) in PIK3CA-mutant (mt) ER …
- Effect of L‑arginine supplementation on the hepatic Phosphatidylinositol 3‑kinase signaling pathway and gluconeogenic enzymes in early intrauterine growth …
- … the Growth Hormone Gene Transcription by Glucocorticoids In Vitro: Possible Involvement of Membrane Glucocorticoid Receptors and Phosphatidylinositol 3‐kinase …
- A chimeric cyclic interferon-α2b peptide induces apoptosis by sequential activation of Phosphatidylinositol 3–kinase, protein kinase Cδ and p38 MAP kinase
- Altered Phosphatidylinositol 3–kinase and calcium signaling in cardiac dysfunction after brain death in rats
- Prucalopride inhibits proliferation of ovarian cancer cells via Phosphatidylinositol 3–kinase (PI3K) signaling pathway
- Correction: The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to Phosphatidylinositol 3–kinase inhibition …
- Abstract CT212: CHRONOS-2: a randomized, double-blind phase III study of Phosphatidylinositol–3 kinase alpha/delta inhibitor copanlisib versus placebo in patients …
- IKBKE protein activates Akt independent of Phosphatidylinositol 3–kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.
- Phosphatidylinositol–3 kinase-Akt-mammalian target of rapamycin signaling pathway mediates contractility of human endometriotic stromal cells: A promising …
- BELLE-3: A Phase III study of the pan-Phosphatidylinositol 3–kinase (PI3K) inhibitor buparlisib (BKM120) with fulvestrant in postmenopausal women with HR+/HER2 …
- PG201 downregulates the production of nitrite by upregulating heme oxygenase-1 expression through the control of Phosphatidylinositol 3–kinase and NF-E2-related …
- Electrochemical assay of the relationship between the inhibition of Phosphatidylinositol 3–kinase pathway and estrogen receptor expression in breast cancer
- Enantioselective Total Synthesis of (–)‐Siphonodictyal B and (+)‐8‐epi‐Siphonodictyal B with Phosphatidylinositol 3‐kinase α (PI3Kα) Inhibitory Activity
- … apoptosis by Dae-Hwang-Mok-Dan-Tang in HCT-116 colon cancer cells through activation of caspases and inactivation of the Phosphatidylinositol 3–kinase …
- Recombinant human erythropoietin augments neovascularization responses in a neonatal rat model of premature brain damage by Phosphatidylinositol 3 kinase/Akt …
- Short-term low-protein diet during pregnancy alters islet area and protein content of Phosphatidylinositol 3–kinase pathway in rats
- … and optimisation of 4, 5-dihydrobenzo [1, 2-d: 3, 4-d] bisthiazole and 4, 5-dihydrothiazolo [4, 5-h] quinazoline series of selective Phosphatidylinositol–3 kinase alpha …
- … ‐Containing Inositol 5′‐Phosphatase Ameliorates High Glucose‐Induced Extracellular Matrix Deposition via the Phosphatidylinositol 3‐kinase/Protein kinase B …
- Non-canonical regulation of Phosphatidylinositol 3–kinase gamma isoform activity in retinal rod photoreceptor cells
- Homocysteine ameliorates the endothelium-independent hypoxic vasoconstriction via the suppression of Phosphatidylinositol 3–kinase/Akt pathway in porcine …
- Influence of Phosphatidylinositol–3–kinase/protein kinase b-mammalian target of rapamycin signaling pathway on the neuropathic pain complicated by nucleoside …
- Phosphatidylinositol 3–kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin.
- Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and Phosphatidylinositol 3–kinase/AKT activation in colon carcinoma cells …
- PIPA: A phase Ib study of selective ß-isoform sparing Phosphatidylinositol 3–kinase (PI3K) inhibitor taselisib (T) plus palbociclib (P) in patients (pts) with advanced …
- Protective effect of hydrogen-rich water on oxidative stress cell model and the impact of the Phosphatidylinositol 3 kinase/protein kinase B pathway
- Vitamin D3 Activates Phosphatidylinositol–3–kinase/Protein kinase B via Insulin-Like Growth Factor-1 to Improve Testicular Function in Diabetic Rats
- … in the activation of promatrix metalloproteinase-2 and membrane type-1-matrix metalloproteinase expression via a Phosphatidylinositol–3–kinase pathway in human …
- Geranylgeranylacetone exerts neuroprotective roles through medicating the Phosphatidylinositol–3 kinase/Akt signaling pathway in an intracerebral hemorrhage rat …
- Apoptotic effect of Phosphatidylinositol 3–kinase inhibition on acute lymphoblastic leukemia cells using buparlisib
- Induction of apoptosis and suppression of angiogenesis of hepatocellular carcinoma by HS-159, a novel Phosphatidylinositol 3–kinase inhibitor
- [3a,4]-Dihydropyrazolo[1,5a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol–3–kinase β Inhibitors
- Functional differentiation of three Phosphatidylinositol 3–kinase catalytic subunit alpha (PIK3CA) in response to Vibrio anguillarum infection in turbot (Scophthalmus …
- A pivotal role of Phosphatidylinositol 3–kinase in delaying of methyl jasmonate-induced leaf senescence
- Fibroblast growth factor type 1 receptor stimulation of T-type Ca2+ channels in sensory neurons requires the Phosphatidylinositol 3–kinase and protein kinase A …
- Puquitinib mesylate, an inhibitor of Phosphatidylinositol 3–kinase p110δ, for treating relapsed or refractory non-Hodgkin’s lymphoma
- Expression pattern of class I phosphoinositide 3–kinase and distribution of its product, Phosphatidylinositol–3, 4, 5-trisphosphate, during Drosophila embryogenesis
- Phosphatidylinositol–3–kinase in tomato (Solanum lycopersicum. L) fruit and its role in ethylene signal transduction and senescence
- Characterization and Differentiation of Circulating Blood Mesenchymal Stem Cells and the Role of Phosphatidylinositol 3–kinase in Modulating the Adhesion
- Chronic treatment with LY294002, an inhibitor of Phosphatidylinositol 3–kinase, attenuates ischemia/reperfusion-induced cardiac dysfunction in normotensive and …
- HS-133, a novel fluorescent Phosphatidylinositol 3–kinase inhibitor as a potential imaging and anticancer agent for targeted therapy
- Derivation and characterization of endometrial cancer cells resistant to Phosphatidylinositol–3–kinase (PI3K) pathway inhibitors.
- Phosphatidylinositol phosphate 5-kinase Iγ and phosphoinositide 3–kinase/Akt signaling couple to promote oncogenic growth
- Dehydroglyasperin D inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with Phosphatidylinositol 3–kinase
- … monophosphate signaling pathway (cAMP), DLK signaling pathway, RAS/RAF signaling, retinoic acid signaling, Phosphatidylinositol 3–kinase (PI3K) as the signaling …
- Potent inhibitors of Phosphatidylinositol 3 (PI3) kinase that have antiproliferative activity only when delivered as prodrug forms
- Activation of Phosphatidylinositol 3–kinase/Akt pathway by androgen through interaction of p85α, androgen receptor, and Src.
- Enhancement of glucose uptake by Ficus hispida methanolic extract through Phosphatidylinositol 3 kinase and inhibiting aldose reductase–an in vitro analysis
- Angiopoietin-2 induces the neuronal differentiation of mouse embryonic NSCs via Phosphatidylinositol 3 kinase-Akt pathway-mediated phosphorylation of …
- Effects of Panax quinquefolium saponin on Phosphatidylinositol 3–kinase/serine threonine kinase pathway of neonatal rat myocardial cells subjected to hypoxia
- Influencing Factors of Phosphatidylinositol 3–kinase Membrane Binding and Catalysis
- BRAF, KRAS, and Phosphatidylinositol 3–kinase in the management of metastatic colorectal cancer
- Cysteine‑rich 61 RNA interference inhibits pathological angiogenesis via the Phosphatidylinositol 3‑kinase/Akt‑vascular endothelial growth factor signaling …
- Candesartan Restores the Amyloid Beta-Inhibited Proliferation of Neural Stem Cells by Activating the Phosphatidylinositol 3–kinase Pathway
- Phosphatidylinositol–3–kinase mutations are associated with increased local failure in brain metastases treated with radiation
- Influence of pertussis toxin on GPER-mediated activation of Phosphatidylinositol 3–kinase/protein kinase B signaling induced by 17β-estradiol in endometrial …
- Overcoming ibrutinib resistance by targeting Phosphatidylinositol–3–kinase signaling in diffuse large B-cell lymphoma
- Sirolimus therapy for a patient with segmental overgrowth due to a mosaic activating mutation in Phosphatidylinositol–3–kinase
- Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of Phosphatidylinositol–3 kinase …
- Hematopoietic stem cell transplantation for progressive combined immunodeficiency and lymphoproliferation in patients with activated Phosphatidylinositol–3-OH …
- Integration of Phosphatidylinositol 3–kinase (PI3K) activity and inflammatory signaling pathways in autoimmune disease
- The Phosphatidylinositol–3–kinase (PI3K) inhibitor (i) copanlisib is active in preclinical models of B-cell lymphomas as single agent and in combination with …
- Effects of rifampin on the pharmacokinetics of copanlisib, a novel pan-class I Phosphatidylinositol–3–kinase (PI3K) inhibitor in cancer patients.
- Possible Involvement of’Phosphatidylinositol–3 kinase and endothelial nitric oxide synthase’in experimental obesity induced vascular endothelium dysfunction
- Participation of actin filaments, myosin and Phosphatidylinositol 3‐kinase in the formation and polarisation of tetraspore germ tube of Gelidium floridanum …
- … and sepsis in patients with relapsed and refractory chronic lymphocytic leukemia/small lymphocytic lymphoma treated with Phosphatidylinositol 3–kinase …
- Withdrawal: Transformation potential of Ras isoforms correlates with activation of Phosphatidylinositol 3–kinase but not ERK
- Protein kinase Cζ exhibits constitutive phosphorylation and Phosphatidylinositol–3, 4, 5-triphosphate-independent regulation
- Docking Study to Predict the Efficacy of Phosphatidylinositol 3–kinase α Inhibitors
- Proteomic profiling of Phosphatidylinositol 3–kinase (PI3K) altered metastatic colorectal cancer (mCRC) after protein kinase B (Akt) inhibition: Insulin like growth factor …
- Role of Phosphatidylinositol-4, 5-bisphosphate 3–kinase signaling in vesicular trafficking
- Osteopontin induced vascular endothelial growth factor production in dispersed nasal polyp cells through the Phosphatidylinositol 3–kinase–protein kinase B and the …
- … factor negatively regulates the insulin-like growth factor signaling pathway through the coordinated action of Phosphatidylinositol 3–kinase and protein kinase …
- [Corrigendum] Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the Phosphatidylinositol 3–kinase signaling pathway in human …
- Effect of paired using tangerine peel and ternate Pinellia tuber on the expressions of Phosphatidylinositol 3–kinase and phosphorylation of protein kinase B/Akt in …
- A combination therapy of atypical protein kinase inhibitor and Phosphatidylinositol–3–kinase inhibitor reduces multidrug resistance in renal cell carcinoma (RCC)
- Alpelisib. Phosphatidylinositol 3–kinase alpha (PI3K alpha) inhibitor Oncolytic
- A potential role of toll-like receptors, IFN-γ and the Phosphatidylinositol 3–kinase pathway in the pathogenesis of acquired mediastinal lymphatic malformation
- Effects and mechanisms of Phosphatidylinositol 3 kinase B signal pathway on colon cancer cell SW480
- Investigating the Phosphatidylinositol 3‘kinase signalling pathway in transgenic mouse models of breast cancer
- Detection of” Hotspot Mutations in Catalytic Subunit of Phosphatidylinositol 3–kinase (Pik3ca) by Allele-Specific Polymerase Chain Reaction
- Phosphatidylinositol 3-phosphate 5-kinase, FAB1/PIKfyve kinase mediates endosome maturation to establish endosome-cortical microtubule interaction in …
- A randomized phase II study (B2151005) of the intravenous Phosphatidylinositol 3–kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor PF-05212384 plus …
- … by suppressing phosphatase and tensin homologue deleted on chromosome 10 and activating the Phosphatidylinositol–3–kinase/Akt signalling pathway
- … osmolality promotes adipocytogenic differentiation of primary rat osteoblasts in a protein kinase A and Phosphatidylinositol 3–kinase/Akt-dependent manner
- Role of Phosphatidylinositol 3–kinase-protein kinase B signaling pathway in Na+-I-symporter expression for lactating breast cells
- The Association of Lipoprotein Lipase and Phosphatidylinositol 3‐kinase with Macrophage Lipid Accumulation
- Design, synthesis, and biological evaluation of thieno [3, 2‐d] pyrimidine derivatives as potential simplified Phosphatidylinositol 3‐kinase alpha inhibitors
- Targeting the Phosphatidylinositol 3–kinase signaling pathway to inhibit pathogenic B cells in systemic lupus erythematosus (SLE)
- Phosphatidylinositol 3–kinase and insulin receptor substrate-1 gene polymorphism/adipocytokines interaction in pathogenesis of insulin resistance among …
- The effects of (−)‐epigallocatechin‐3‐gallate (EGCG) and Phosphatidylinositol 3‐kinase (PI (3) K) inhibition on Burkitt lymphoma cells
- Correction for Thaa et al., Differential Phosphatidylinositol–3–kinase-Akt-mTOR activation by Semliki forest and chikungunya viruses is dependent on nsP3 and …
- … on high insulin induced cell proliferation of human glomerular mesangial cells and the expression of insulin receptor substrate 1 and Phosphatidylinositol–3–kinase
- … in signal transducer and activator 5B (STAT5B), Phosphatidylinositol 3–kinase catalytic subunit delta (PIK3CD) and Phosphatidylinositol 3–kinase regulatory subunit 1 …
- Phosphatidylinositol 3–kinase Pathway
- Combined Inhibition of Phosphatidylinositol 3–kinase (PI3K) Isoform α and δ By the Pan-Class I PI3K Inhibitor SAR245409 (XL765) in Primary Chronic …
- Phosphatidylinositol 3–kinase delta pathway
- Examining Mechanisms of Sensitivity and Resistance to Phosphatidylinositol 3–kinase inhibitors in Head and Neck Squamous Cell Carcinoma
- Phosphatidylinositol–3 kinase (PI3–kinase) HAS A PROTECTIVE ROLE IN ANGIOTENSIN II-INDUCED PODOCYTE INJURY
- VJR‐TZ‐18: Novel Phosphatidylinositol‐3‐kinase (PI3K) Delta Inhibitor Exerts Antitumor Activity via Induction of Autophagy and Apoptosis in Breast Cancer In Vitro …
- Inhibition of Phosphatidylinositol–3–kinase by the Furanosteroid Hibiscone C
- Roles of Phosphatidylinositol 3–kinase/protein kinase B signaling pathway in skeletal muscle, peroxisome proliferator-activated receptor γ and phosphatase and …
- Oncogenic BRAF fusion induces MAPK-pathway activation targeted by MEK inhibitor and Phosphatidylinositol 3–kinase inhibitor combination treatment in mucosal …
- ROLE OF Phosphatidylinositol–3–kinase IN CARCINOGENESIS
- The role of class IA Phosphatidylinositol-4, 5-bisphosphate 3–kinase catalytic subunits in glioblastoma
- Architecture and dynamics of the autophagic Phosphatidylinositol 3–kinase complex
- Effect of NVP-BEZ235, dual Phosphatidylinositol 3–kinase/mammalian target of rapamycin inhibitor, on radiosensitivity of oral cancer cell line through G2/M phase …
- Inhibition of Bromodomain-Containing 4 Sensitises Aggressive Non-Hodgkin Lymphomas to Phosphatidylinositol 3–kinase δ Inhibitors
- Inhibition of Phosphatidylinositol–3–kinase by the Furanosesquiterpenoid Hibiscone C and its Derivatives
- Inhibition of Phosphatidylinositol 3–kinase α(PI3Kα) prevents heterotopic ossification
- Designing Compounds that Probe the Phosphatidylinositol 3–kinase Signalosome
- Metabolic Channeling from the Insulin Receptor to a Novel Class II Phosphatidylinositol 3‘-kinase and Then to the Threonine-308 Site on AKT Drives Overactive de …
- Efficacy of Phosphatidylinositol 3–kinase (PI3K) Inhibitors in Patients with Relapsed and Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic …
- Anti-cancer effect of Phosphatidylinositol 3–kinase inhibitor on NB4 leukemic cells
- The Phosphatidylinositol 3‐kinase Pathway in Human Malignancies
- Distinct and opposing roles for the Phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and …
- Phosphatidylinositol 3–kinase (PI3K) Inhibitors-Related Hematological Toxicities in Patients with Relapsed and Refractory Chronic Lymphocytic Leukemia …
- UTILITY OF Phosphatidylinositol 3–kinase INHIBITORS IN GASTROINTESTINAL CANCER
- The function of Phosphatidylinositol 3–kinase delta (PI3Kδ) enzyme in protective immunity to Trypanosoma congolense infection in mice: role of regulatory B cells
- The class II Phosphatidylinositol 3-phosphate kinase PIK3C2A promotes Shigella flexneri dissemination through formation of vacuole-like protrusions
- The Inhibition of Phosphatidylinositol–3–kinase in activated T-cells by Hibiscone C derivatives
- Phosphatidylinositol 3–kinase (PI3K) as a therapeutic target in NSCLC
- THU0326 ANALYSIS OF Phosphatidylinositol 3–kinase PATHWAY IN B CELL ACTIVATION OF SYSTEMIC SCLEROSIS PATIENTS
- Data on Lipocalin 2 and Phosphatidylinositol 3–kinase signaling in a methionine-and choline-deficient model of non-alcoholic steatohepatitis
- Phosphatidylinositol 3–kinase/serine-threonine kinase signaling pathway and its regulation mechanisms in muscle growth and development.
- Inhibition of Phosphatidylinositol–3–kinase by Hibiscone C in T cells
- PIK3R2 (p85β)–Phosphatidylinositol 3–kinase β-Subunit
- Activation of Phosphatidylinositol–3′-kinase/Akt signaling in myxoid liposarcoma
- Umbralisib tosylate. Phosphatidylinositol 3–kinase delta (PI3Kdelta) inhibitor, Hematological cancer therapy
- Blocking the Phosphatidylinositol 3–kinase Pathway Inhibits
- Progress of Phosphatidylinositol 3–kinase signaling pathway and its inhibitors in lymphoma
- Inhibition of Phosphatidylinositol 3–kinase signaling antagonizes paclitaxel-mediated resistance in cervical cancer
- Sonolisib: Pan-Phosphatidylinositol 3–kinase (PI3K) inhibitor, Oncolytic
- EP256 Inhibition of Phosphatidylinositol 3–kinase (PI3K) signaling synergistically potentiate antitumor efficiency of paclitaxel and overcome paclitaxel-mediated …
- Incidence of diabetes and its predictive factors in cancer patients treated with Phosphatidylinositol 3 kinase inhibitors
- Docking Studies of Isoform-Selectivity of Phosphatidylinositol 3–kinase (PI3K) Inhibitors
- Abstract B053: Phosphatidylinositol 3 kinase (PI3K) inhibitors as therapeutic agents for breast tumors overexpressing sfRon
- Regulation of Phosphatidylinositol 3–kinase (PI3K/Akt) pathway in chicken and duck cells and its implications for influenza A virus pathogenesis
- Reconstitution of the Class III Phosphatidylinositol‐3‐kinase in autophagy
- MON-205 THE PROTECTIVE ROLE OF Phosphatidylinositol–3 kinase (PI3–kinase) IN ANGIOTENSIN II-INDUCED PODOCYTE INJURY
- PO-GO20: Paclitaxel-resistant cervical cancer and Phosphatidylinositol 3–kinase inhibitor
- EFFECTS OF Phosphatidylinositol–3–kinase (PI3K) INHIBITOR ON CELLULAR SIGNAL NETWORKS IN GLIOMA CELL LINES.
- Syndromic Hypoketotic, Hypoinsulinemic Hypoglycaemia due to a Mosaic Activating Phosphatidylinositol 3–kinase Mutation
- In vitro anticancer activity of Phosphatidylinositol 3–kinase alpha selective inhibitor BYL719 in head and neck cancer
- Early activation of Phosphatidylinositol 3–kinase for neuroprotective effect against ischemic stroke and behavior functional test
- Next-generation sequencing demonstrates genomic signature of resistance patterns following Phosphatidylinositol 3–kinase (PI3K) inhibition
- Enhanced effect of rsTRAIL-based therapy for A549 cells by Phosphatidylinositol 3′-kinase inhibitor LY294002
- Modulation of the DNA-Damage Response by Inhibitors of the Phosphatidylinositol 3–kinase Related kinase (PIKK) Family
- Phosphatidylinositol 3–kinase b and d isoforms play key roles in metastasis of prostate cancer DU145 cells
- Preclinical evaluation of a 18F-labeled Phosphatidylinositol 3–kinase inhibitor for breast cancer imaging
- Is Phosphatidylinositol 3–kinase/AKT/mammalian target of rapamycin pathway therapeutic target for esophageal adenocarcinoma
- Research progress of Phosphatidylinositol 3–kinase/AKt signaling pathway and mechanisms of resistance to sorafenib in hepatocellular carcinoma
- Withdrawal: Cooperative regulation of NOTCH1 protein-Phosphatidylinositol 3–kinase (PI3K) signaling by NOD1, NOD2, and TLR2 receptors renders enhanced …
- Role of Phosphatidylinositol 3–kinase (PI3K) in protein kinase C (PKC)-induced breast cancer cell metastasis
- The expression and clinical significance of Phosphatidylinositol 3–kinase and protein kinase B in the tissue of epithelial ovarian cancer
- Inhibition of Phosphatidylinositol 3–kinase suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil
- Targeting compensatory mechanisms of resistance to Phosphatidylinositol 3–kinase inhibitors in head and neck squamous cell carcinoma
- Tomato pistil factor STIG1 promotes in vivo pollen tube growth by binding to Phosphatidylinositol 3-phosphate and the extracellular domain of the pollen receptor …
- Experimental study on Phosphatidylinositol 3 kinase signal transduction pathway in Barrett esophagus genesis
- … survival in cancer via the up-regulation of fat mass and obesity-associated (FTO) gene expression and activation the Phosphatidylinositol–3–kinase/protein kinase B …
- Expressions of Phosphatidylinositol 3–kinase/protein kinase B signaling pathway proteins in the whole bolld of patients with Kashin-Beck disease
- Oncogenic mutations weaken the interactions that stabilize the p110a-p85a heterodimer in Phosphatidylinositol 3–kinase
- Metabolic biomarkers predict the sensitivity to Phosphatidylinositol 3–kinase pathway inhibitor in small-cell lung carcinoma
- Effects of Phosphatidylinositol–3 kinase-protein kinase B signaling pathway on iodine-intake ability of lactating rats
- Activity of the Phosphatidylinositol 3–kinase (PI3K) Inhibitor, Copanlisib, As a Single Agent and in Combination with Carfilzomib in Multiple Myeloma
- Phosphatidylinositol 3–kinase mediates oral IGF-I stimulation of Na+, K+-ATPase activity and Na+-coupled nutrient absorption in piglet jejunum
- Phosphatidylinositol 3–kinase/protein kinase B/mammalian target of rapamycin signaling pathway and epilepsy
- Expression of the Phosphatidylinositol 3–kinase signaling pathway in peripheral blood T cells from patients with atopic dermatitis
- Targeting the Phosphatidylinositol 3–kinase/Akt/mechanistic target of rapamycin (PI3K/Akt/mTOR) signaling pathway in B-lineage acute lymphoblastic leukemia
- Influences of plumbagin on Phosphatidylinositol 3–kinase/protein kinase B signaling pathway in rats with hepatic fibrosis
- Perspectives on targeting the Phosphatidylinositol 3–kinase pathway for personalized medicine in endometrial and ovarian cancers
- InsulinǦlike growth factor–Phosphatidylinositol 3 kinase signaling in canine cortisolǦsecreting adrenocortical tumors
- Ashwagandha and Its Active Ingredient, Withanolide A, Increase Activation of the Phosphatidylinositol 3‘kinase/Akt Cascade in Hippocampal Neurons
- Altered Phosphatidylinositol 3–kinase and calcium signaling in cardiac dysfunction after brain death in rats
- Overcoming anti-estrogen resistance in estrogen receptor (ER)-positive breast cancer: rational targeting of Phosphatidylinositol 3–kinase (PI3K) and the resurrection of …
- Phosphatidylinositol 3–kinase (PI3K) and mTOR inhibitors demonstrate broad efficacy and synergy in head and neck cancer cell lines and patient-derived xenografts
- DETERMINATION OF Phosphatidylinositol–3–kinase GENE COPY NUMBER AND PROTEIN EXPRESSION IN NASOPHARYNGEAL CARCINOMA BY …
- Chimeric Nanoparticle: A Platform for Simultaneous Targeting of Phosphatidylinositol–3–kinase Signaling and Damaging DNA in Cancer Cells
- A Phosphatidylinositol 3–kinase Inhibitor strongly suppressed pulmonary vascular remodeling in a murine model of allergic vasculitis
- Role of Phosphatidylinositol 3‐kinase in ouabain‐induced cardiac cell signaling and hypertrophy
- Efficacy of self-made Gengnian decoction on Phosphatidylinositol 3–kinases/protein kinase B/mammalian target of rapamycin signaling pathway in perimenopausal …
- Role of Phosphatidylinositol 3–kinase p110β in spinal dorsal horn neurons in the development of arthritic pain in rats: relationship with TRPV1 and ASIC1a
- … renal tubulo-interstitial nephritis antigen (TINag) in cell survival utilizing integrin αvβ3/focal adhesion kinase (FAK)/Phosphatidylinositol 3–kinase (PI3K)/protein kinase …
- Abstract CT084: A randomized, double-blind phase III study of Phosphatidylinositol–3 kinase alpha/delta inhibitor copanlisib versus placebo in patients with rituximab …
- Remote limb ischemic postconditioning protects focal cerebral ischemia-reperfusion injury in rats via Phosphatidylinositol 3 kinase/Akt pathway
- Abstract LB-A20: Novel Dual Oncogenic Target Inhibitor against Allosteric Mitogen-Activated Protein kinase (MEK1) and Phosphatidylinositol 3–kinase (PI3K)
- Expression of Phosphatidylinositol 3–kinase, Protein kinase B and Mammalian Target of Rapamycin in Substan-tia Nigra in Rats with Parkinson’s Disease
- Organic synthesis of novel Phosphatidylinositol 3‐kinase (PI3K) inhibitors activated by prostate specific antigen (PSA) for the treatment of androgen‐independent …
- β-inducible gene-h3 promotes human breast carcinoma cell metastasis by activating the Phosphatidylinositol 3–kinase/protein kinase B signaling pathway
- Response of Subcutaneous Xenografts of Endometrial Cancer in Nude Mice to Inhibitors of Phosphatidylinositol 3–kinase/Akt and Mitogen-Activated Protein …
- … growth factor-induced angiogenesis by inhibiting Ras-dependent mitogen-activated protein kinase (MAPK) and Phosphatidylinositol 3–kinase (PI3K)/Akt signaling …
- Lymph node-associated stromal fibroblasts as a potential source of humoral factors to support B-cell lymphoma cells via the Phosphatidylinositol 3–kinase pathway
- Phosphatidylinositol 3–kinase (PI3Kα)/AKT axis blockade with taselisib or ipatasertib enhances the efficacy of anti-microtubule drugs in human breast cancer cells
- Lipopolysaccharide enhances Wnt5a expression through toll-like receptor 4, myeloid differentiating factor 88, Phosphatidylinositol 3-OH kinase/AKT and nuclear factor …
- The p110δ Isoform of Phosphatidylinositol 3–kinase Controls Susceptibility to Chlamydia muridarum lung infection by reducing Th1 and Th17 immune response
- The role and regulation of the p84 adaptor subunit in Phosphatidylinositol 3–kinase γ lipid-kinase signalling and the control of PI3Kγ-dependent cell migration
- Key roles for Gab1, Phosphatidylinositol–3–kinase, COX-2, prostaglandin E2 and TGF-alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth …
- Inhibitory of Dexamethasone on podocytes apoptosis induced by Puromycin via stabilizing Phosphatidylinositol 3 kinase/protein kinase B signaling pathway
- Angiotensin II-Induced Generation of Reactive Oxygen Species Is Regulated by a Phosphatidylinositol 3–kinase/L-Type Calcium Channel Signaling Pathway
- A Phosphatidylinositol 3–kinase Inhibitor (PI3K) Strongly Suppressed Inflammation And Pulmonary Vascular Remodeling In A Murine Model Of Allergic Vasculitis
- Design, Synthesis, and Screening of Novel Phosphatidylinositol 3–kinase (PI3K) Inhibitors Activated by Prostate Specific Antigen (PSA): Prodrug Treatment for …
- Effect of Isoalantolactone on Apoptosis in MCF-7 Cells Via Mitochondrial and Phosphatidylinositol 3–kinase/Akt Signaling Pathways
- Helicobacter pylori Induced Phosphatidylinositol–3-OH kinase/mTOR Activation Increases Hypoxia Inducible Factor-1α to Promote Loss of Cyclin D1 and G0 …
- Abstract CT215: CHRONOS-1: Open-label, uncontrolled phase II trial of intravenous Phosphatidylinositol–3 kinase alpha/delta inhibitor copanlisib in patients with …
- Significance of abnormal expression of CD2-associated protein and Phosphatidylinositol 3–kinase p85 in apoptosis of podocytes induced by puromycin …
- O-018: Activation of Phosphatidylinositol 3–kinase/AKT/Snail Sig-nalling Pathway Contributes to Epithelial-Mesenchymal Transition-Induced Multi-Drug Resistance to …
- Phosphatidylinositol 3–kinase class II α-isoform PI3K-C2α is required for transforming growth factor B-induced Smad signaling in endothelial cells
- … and Development: Relaxin confers cytotrophoblast protection from hypoxia-reoxygenation injury through the Phosphatidylinositol 3–kinase-Akt/protein kinase …
- Effect of Atorvastatin on apoptosis of HL-60 leukemic cells via the regulation of the Phosphatidylinositol 3–kinase/serine/threonine protein kinase/mammalian target of …
- Differential effects of Phosphatidylinositol 4-kinase (PI4K) and 3–kinase (PI3K) inhibitors on stomatal responses to environmental signals
- Phosphatidylinositol–3–kinase C2B and TRIM27 Function to Positively and Negatively Regulate IGE Receptor Activation of Mast Cells
- Effect of aerobic exercise combined with resistive exercise on vascular endothelial function and its impact on Phosphatidylinositol 3–kinase/protein kinase B …
- … II (Ang II) Increases Phosphorylation of Rat Kidney Na, K‐Pump at S938 in Proximal Tubule (PCT) Cells through a Phosphatidylinositol 3′‐kinase (PI3K)/Akt Pathway …
- Brassinin induces G1 phase arrest through increase of p21 and p27 by inhibition of the Phosphatidylinositol 3–kinase signaling pathway in human colon cancer cells
- Immunohistochemical Targeting of p110β Isoform of Phosphatidylinositol 3–kinase co-associated with Cyclin-Dependent kinase 1 in a Group of Tissues from Iraqi …
- … genomic signature highlights sustained AKT and estrogen receptor signaling as key mediators of resistance following Phosphatidylinositol 3–kinase (PI3K) inhibition in …
- Effects of Endurance Exercise and Ginsenoside Rb1 on AMP-Activated Protein kinase, Phosphatidylinositol 3–kinase Expression and Glucose Uptake in the Skeletal …
- Participation of Phosphatidylinositol–3‘-kinase in Perception and Signal Transduction through Galactosyl-Containing Glycoprotein Receptors of Segmented …
- Platelet CD40L Affects Thrombus Formation via Phosphatidylinositol 3–kinase ß, But Not Via CD40 or IKKα
- C36 NOVEL MECHANISMS OF ALLERGIC AIRWAY INFLAMMATION IN ANIMAL MODELS: A Phosphatidylinositol 3–kinase Inhibitor (pi3k) Strongly Suppressed …
- Phosphatidylinositol–3–kinase p110d Uniquely Promotes Gain-Of-Function PTPN11-Induced GM-CSF Hypersensitivity In a Model Of Juvenile Myelomonocytic …
- 035—(LIM0021) The role of Phosphatidylinositol 3–kinase (PI3K) on seizures, neurogenesis, and neurotrophin levels induced by intrahippocampal microinjection of …
- … : CHRONOS-3: A phase III, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of Phosphatidylinositol–3 kinase (PI3K) alpha/delta …
- Glycogen Synthase kinase 3 Influences Cell Motility and Chemotaxis by Regulating Phosphatidylinositol 3 kinase Localization in Dictyostelium discoideum
- 318 Impact of dietary fatty acid source on ovarian Phosphatidylinositol–3 kinase signaling
- Effect of tert-Butylhydroquinone on the expression of nuclear factor erythroid 2-related factor 2, heme oxygenase-1 and Phosphatidylinositol 3–kinase in high glucose …
- Effects of Src Homolog Phosphatase-1 (SHP-1) on Janus kinase 2 (JAK/STAT) and Phosphatidylinositol 3–kinase (PI3–kinase) Pathways in 7 and 28 day Renal-Wrap …
- Synthesis and evaluation of imidazo [1, 2-a] pyridine analogues of the Phosphatidylinositol 3–kinase inhibitor ZSTK474
- P2. 03b-071 Therapeutic Targeting of the Phosphatidylinositol–3 kinase Pathway in Lung Squamous Cell Carcinoma: Topic: Biomarkers
- RGC-32 regulates T lymphocyte cell cycle activation in a Phosphatidylinositol 3–kinase and IL-2-dependent manner (IRC8P. 442)
- Class III Phosphatidylinositol–3-OH kinase controls epithelial integrity through endosomal LKB1 regulation
- … analysis with reverse phase protein array identifies N-myc downstream regulated gene 1 (NDRG1) as a biomarker of Phosphatidylinositol–3–kinase (PI3K) α inhibitor …
- … CT157: Clinical pharmacokinetics and pharmacodynamics of ME-401, an oral, potent and selective inhibitor of Phosphatidylinositol 3–kinase P110δ, following single …
- Clinical Pharmacokinetics and Pharmacodynamics of Pwt-143, an Oral, Potent and Selective Inhibitor of Phosphatidylinositol 3–kinase P110delta, Following Single …
- The role of Phosphatidylinositol–3-OH-kinase (PI3–kinase) and respiratory burst enzymes in the [omim][BF4]-mediated toxic mode of action in mussel hemocytes
- Phosphatidylinositol‐4, 5‐bisphosphate 3‐kinase catalytic subunit alpha (PIK3CA)‐related overgrowth spectrum: A brief report
- Resveratrol attenuates intermittent hypoxia‑induced insulin resistance in rats: Involvement of Sirtuin 1 and the Phosphatidylinositol‑4, 5‑bisphosphate 3‑kinase …
- Phosphatidylinositol-4, 5-Bisphosphate 3–kinase (PIK3Ca)
- Dynamic regulation of Phosphatidylinositol 3, 5-bisphosphate and its upstream lipid kinase Fab1/PIKfyve
- Phosphatidylinositol 3‐Phosphate Mimics Based on a Sulfoquinovose Scaffold: Synthesis and Evaluation as Protein kinase B Inhibitors
- Interaction of human biliverdin reductase with Akt/protein kinase B and Phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity …
- Managing toxicities of Phosphatidylinositol–3–kinase (PI3K) inhibitors
- Effects of chitosan and oligochitosans on the Phosphatidylinositol 3–kinase-AKT pathway in cancer therapy
- Properties of FDA-approved small molecule Phosphatidylinositol 3–kinase inhibitors prescribed for the treatment of malignancies
- Structural basis of Phosphatidylinositol 3–kinase C2α function
- Phosphatidylinositol 3–kinase (PI3K) inhibitors: A recent update on inhibitor design and clinical trials (2016–2020)
- Class II Phosphatidylinositol 3–kinase isoforms in vesicular trafficking
- Radiosensitising cancer using Phosphatidylinositol–3–kinase (PI3K), protein kinase B (AKT) or mammalian target of rapamycin (mTOR) inhibitors
- Risk1, a Phosphatidylinositol 3–kinase effector, promotes Rickettsia typhi intracellular survival
- Phosphatidylinositol 3–kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4
- Phosphatidylinositol 3–kinase signaling and immune regulation: insights into disease pathogenesis and clinical implications
- AUTOPHAGY-RELATED14 and Its associated Phosphatidylinositol 3–kinase complex promote autophagy in Arabidopsis
- Targeting Phosphatidylinositol 3‐kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors
- Phase Ib Study of Combination Therapy with MEK Inhibitor Binimetinib and Phosphatidylinositol 3‐kinase Inhibitor Buparlisib in Patients with Advanced Solid Tumors …
- Testing considerations for Phosphatidylinositol‐3‐kinase catalytic subunit alpha as an emerging biomarker in advanced breast cancer
- Single-agent activity of Phosphatidylinositol 3–kinase inhibition with copanlisib in patients with molecularly defined relapsed or refractory diffuse large B-cell …
- Epigenetic regulation of microglial Phosphatidylinositol 3‐kinase pathway involved in long‐term potentiation and synaptic plasticity in rats
- Loss of Phosphatidylinositol 3–kinase activity in regulatory T cells leads to neuronal inflammation
- Wortmannin targeting Phosphatidylinositol 3‐kinase suppresses angiogenic factors in shear‐stressed endothelial cells
- GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing Phosphatidylinositol 3–kinase complex
- Targeting Phosphatidylinositol 3 kinase-β and-δ for Bruton tyrosine kinase resistance in diffuse large B-cell lymphoma
- STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III Phosphatidylinositol 3–kinase complex I
- Class III Phosphatidylinositol 3–kinase complex I subunit NRBF2/Atg38-from cell and structural biology to health and disease
- Anticancer effects of veratramine via the Phosphatidylinositol–3–kinase/serine-threonine kinase/mechanistic target of rapamycin and its downstream signaling …
- Predicting genomic alterations of Phosphatidylinositol–3 kinase signaling in hepatocellular carcinoma: a radiogenomics study based on next-generation sequencing …
- Multitarget Inhibition of Histone Deacetylase (HDAC) and Phosphatidylinositol‐3‐kinase (PI3K): Current and Future Prospects
- Research advances on selective Phosphatidylinositol 3 kinase δ (PI3Kδ) inhibitors
- Management of Phosphatidylinositol–3–kinase Inhibitor-Associated Hyperglycemia
- Role of integrin‑linked kinase in static compressive stress‑induced autophagy via Phosphatidylinositol 3 kinase in human periodontal ligament cells
- Prevalence of Phosphatidylinositol–3–kinase (PI3K) pathway alterations and co-alteration of other molecular markers in breast cancer
- Subunit P60 of Phosphatidylinositol 3–kinase promotes cell proliferation or apoptosis depending on its phosphorylation status
- Identification of a potent and selective Phosphatidylinositol 3–kinase δ inhibitor for the treatment of non-Hodgkin’s lymphoma
- The Role of Phosphatidylinositol 3–kinase Catalytic Subunit Type 3 in the Pathogenesis of Human Cancer
- The Evolving Use of Phosphatidylinositol 3–kinase Inhibitors for the Treatment of Chronic Lymphocytic Leukemia
- … fatty liver disease by inhibiting apoptosis and promoting autophagy via reactive oxygen species/Phosphatidylinositol 3–kinase/AKT/mammalian target of …
- Effect of dual inhibition of histone deacetylase and Phosphatidylinositol–3 kinase in Philadelphia chromosome-positive leukemia cells
- Wortmannin, a specific inhibitor of Phosphatidylinositol–3–kinase, induces accumulation of DNA double-strand breaks
- Phosphatidylinositol 3–kinase Glu545Lys and His1047Tyr Mutations are not Associated with T2D
- … lipopolysaccharide-induced inflammation and oxidative stress by activating nuclear factor E2-related factor 2 via the Phosphatidylinositol 3–kinase/AKT pathway in …
- Treadmill exercise in obese maternal rats during pregnancy improves spatial memory through activation of Phosphatidylinositol 3–kinase pathway in the …
- Phosphatidylinositol–3–kinase-Akt pathway in negative-stranded RNA virus infection: a minireview
- Class II Phosphatidylinositol 3–kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells
- Ferulic acid induces apoptosis of HeLa and caski cervical carcinoma cells by Down-Regulating the Phosphatidylinositol 3–kinase (PI3K)/Akt signaling …
- Inhibition of Phosphatidylinositol 3–kinase by Pictilisib Blocks Influenza Virus Propagation in Cells and in Lungs of Infected Mice
- Application of C–H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol–3–kinase Delta Inhibitor Nemiralisib
- Palmatine Derivatives as Potential Antiplatelet Aggregation Agents via Protein kinase G/Vasodilator-Stimulated Phosphoprotein and Phosphatidylinositol 3–kinase …
- Androgens Regulate Tau Phosphorylation Through Phosphatidylinositol 3–kinase–Protein kinase B–Glycogen Synthase kinase 3β Signaling
- … miR-23b-3p promotes osteosarcoma by targeting ventricular zone expressed PH domain-containing 1 (VEPH1)/Phosphatidylinositol 3–kinase/protein kinase B (PI3K …
- The expression level of class III Phosphatidylinositol–3 kinase controls the degree of compensatory nephron hypertrophy
- Shikonin inhibits growth, invasion and glycolysis of nasopharyngeal carcinoma cells through inactivating the Phosphatidylinositol 3 kinase/AKT signal pathway
- Resolvin E3 ameliorates high‐fat diet‐induced insulin resistance via the Phosphatidylinositol‐3‐kinase/Akt signaling pathway in adipocytes
- Epigallocatechin-3-gallate (EGCG) reduces apoptosis of preantral follicles through the Phosphatidylinositol–3–kinase/protein kinase B (PI3K/AKT) signaling pathway …
- Piperine inhibits cell proliferation and induces apoptosis of human gastric cancer cells by downregulating Phosphatidylinositol 3–kinase (PI3K)/Akt pathway
- … lung injury induced by intestinal ischemia/reperfusion by upregulating cannabinoid receptor 2, followed by the activation of the Phosphatidylinositol 3–kinase …
- Predictive and Pharmacodynamic Biomarkers of Response to the Phosphatidylinositol 3–kinase Inhibitor Taselisib in Breast Cancer Preclinical ModelsBiomarkers of …
- High expression levels of centromere protein A plus upregulation of the Phosphatidylinositol 3‑kinase/Akt/mammalian target of rapamycin signaling pathway …
- Association with longevity of Phosphatidylinositol 3–kinase regulatory subunit 1 gene variants stems from protection against mortality risk in men with cardiovascular …
- High mobility group box‐1‐toll‐like receptor 4‐Phosphatidylinositol 3‐kinase/protein kinase B‐mediated generation of matrix metalloproteinase‐9 in the dorsal root …
- Interleukin-17A promotes human disc degeneration by inhibiting autophagy through the activation of the Phosphatidylinositol 3–kinase/Akt/Bcl2 signaling pathway
- S100A16 regulates HeLa cell through the Phosphatidylinositol 3 kinase (PI3K)/AKT signaling pathway
- Efficacy and safety of Phosphatidylinositol 3–kinase inhibitors in patients with chronic lymphocytic leukemia: a meta-analysis and systematic review
- Phosphatidylinositol‐3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells
- Class II Phosphatidylinositol 3–kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in …
- Tubastatin A suppresses the proliferation of fibroblasts in epidural fibrosis through Phosphatidylinositol–3–kinase/protein kinase B/mammalian target of rapamycin …
- Phosphatidylinositol 3–kinase δ Inhibitor-Induced Immunomodulation and Secondary Opportunistic Infection in the Cynomolgus Monkey (Macaca fascicularis)
- Phosphatidylinositol 3–kinase (PI3K) Orchestrates Aspergillus fumigatus-Induced Eosinophil Activation Independently of Canonical Toll-Like Receptor (TLR)/C-Type …
- Phosphatidylinositol 3‐kinase‐δ controls endoplasmic reticulum membrane fluidity and permeability in fungus‐induced allergic inflammation in mice
- … in imiquimod-induced psoriasis on BALB/c mice by inhibiting inflammatory and keratin markers via altering Phosphatidylinositol–3–kinase/protein kinase B …
- Geraniin inhibits proliferation and induces apoptosis through inhibition of Phosphatidylinositol 3–kinase/Akt pathway in human colorectal cancer in vitro and in vivo
- In-silico prediction of potential inhibitors against Phosphatidylinositol 3–kinase catalytic subunit alpha involved in head and neck squamous cell carcinomas
- … by Maintaining Transforming Growth Factor-β1-Induced Expression of Tissue Inhibitor of Metalloproteinase-3 via the Phosphatidylinositol 3–kinase/Akt …
- … intergenic nonprotein coding RNA 0152 promotes hepatocellular carcinoma progression by regulating Phosphatidylinositol 3–kinase/Akt/Mammalian target of …
- … improves Glucocorticoid Receptor-mediated Insulin Resistance via reduction in association of the Glucocorticoid Receptor with Phosphatidylinositol–3–kinase
- … regulates odontogenic differentiation of dental pulp stem cells by activation of mitogen-activated protein kinase and the Phosphatidylinositol 3–kinase …
- Phosphatidylinositol–3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells
- Berberine ameliorates renal impairment and inhibits podocyte dysfunction by targeting the Phosphatidylinositol 3‐kinase–protein kinase B pathway in diabetic rats
- … Contributes to the Development of Cutaneous Squamous Cell Carcinoma by Regulating MicroRNA-148a-3p/EGFR Axis and Activating Phosphatidylinositol 3–kinase …
- Risk of cutaneous adverse events in cancer patients treated with Phosphatidylinositol‐3‐kinase inhibitors: A systematic review and meta‐analysis of randomized …
- Inhibition of integrin subunit alpha 11 restrains gastric cancer progression through Phosphatidylinositol 3–kinase/Akt pathway
- A sensitive HPLC-FLD method for the quantification of alpelisib, a novel Phosphatidylinositol 3–kinase inhibitor, in rat plasma: Drug metabolism and pharmacokinetic …
- Alpha-Enolase Protects Hepatocyte Against Heat Stress Through Focal Adhesion kinase-Mediated Phosphatidylinositol 3–kinase/Akt Pathway
- … 5 (KAT5) promotes the proliferation, invasion and migration of hepatocellular carcinoma through regulating Phosphatidylinositol 3–kinase (PI3K)/protein kinase B (AKT …
- … Pretreatment at Neiguan (PC 6) attenuates autophagy in rats with myocardial ischemia reperfusion through the Phosphatidylinositol 3–kinase-Akt-mammalian target of …
- Lysophosphatidic acid receptor 5 (LPAR5) plays a significance role in papillary thyroid cancer via Phosphatidylinositol 3–kinase/Akt/mammalian target of …
- Role of Phosphatidylinositol 3–kinase and Its Catalytic Unit PIK3CA in Cervical Cancer: A Mini-Review
- … Activating Protein Plays an Oncogenic Role in Neuroblastoma Tumorigenesis and Recurrence Through the Phosphatidylinositol 3–kinase/Protein kinase B …
- … Reductase alleviates oxidative damage-induced apoptosis in alveolar epithelial cells via regulating Phosphatidylinositol–3–kinase/Protein kinase B activation
- Structural and functional characterization of Solanum lycopersicum Phosphatidylinositol 3–kinase C2 domain
- Feasibility of Combining the Phosphatidylinositol 3–kinase Inhibitor Copanlisib With Rituximab-Based Immunochemotherapy in Patients With Relapsed …
- Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via Phosphatidylinositol 3–kinase/AKT/mammalian target of rapamycin and reactive …
- Phase 2 study of TAS-117, an allosteric akt inhibitor in advanced solid tumors harboring Phosphatidylinositol 3–kinase/v-akt murine thymoma viral oncogene …
- Manual Acupuncture at ST37 Modulates TRPV1 in Rats with Acute Visceral Hyperalgesia via Phosphatidylinositol 3–kinase/Akt Pathway
- … exerts anti-cancer activity by modulating adenosine monophosphate-activated protein kinase (AMPK) and the Phosphatidylinositol 3–kinase/protein kinase B (PI3K …
- The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3–kinase Subunits and Inhibits Plasma Cell Differentiation
- Transcriptional reprogramming of intermediate metabolism gene induced by Phosphatidylinositol 3–kinase in Phaeodactylum tricornutum
- Stimulation Phosphatidylinositol 3–kinase/protein kinase B signaling by Porphyromonas gingivalis lipopolysacch aride mediates interleukin-6 and interleukin …
- MiR-126-3p inhibits apoptosis and promotes proliferation by targeting Phosphatidylinositol 3–kinase regulatory subunit 2 in porcine ovarian granulosa cells
- Phosphatidylinositol 3–kinase signaling inhibitors for treatment of multiple myeloma: From small molecules to microRNAs
- Role of Phosphatidylinositol 3‐kinase signaling pathway in radiation‐induced liver injury
- … integrated virtual screening and drug repurposing strategy for the discovery of new antimalarial drugs against Plasmodium falciparum Phosphatidylinositol 3‐kinase
- Arenobufagin Inhibits the Phosphatidylinositol 3–kinase/Protein kinase B/Mammalian Target of Rapamycin Pathway and Induces Apoptosis and Autophagy in …
- Crosslink among Phosphatidylinositol–3 kinase/Akt, PTEN and STAT-5A signaling pathways post liposomal galactomannan hepatocellular carcinoma therapy
- Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of Phosphatidylinositol 3–kinase-related kinases
- Curcumin alleviates rheumatoid arthritis progression through the Phosphatidylinositol 3–kinase/protein kinase B pathway: an in vitro and in vivo study
- Downregulation of PER2 promotes tumor progression by enhancing glycolysis via the Phosphatidylinositol 3–kinase/protein kinase B pathway in oral squamous cell …
- Topoisomerase II alpha promotes gallbladder cancer proliferation and metastasis through activating Phosphatidylinositol 3–kinase/protein kinase B/mammalian target …
- Bupivacaine modulates the apoptosis and ferroptosis in bladder cancer via Phosphatidylinositol 3–kinase (PI3K)/AKT pathway
- Inhibition of Phosphatidylinositol 3–kinase γ by IPI-549 attenuates abdominal aortic aneurysm formation in mice
- Eleutheroside E functions as anti-cervical cancer drug by inhibiting the Phosphatidylinositol 3–kinase pathway and reprogramming the metabolic responses
- Abstract CT140: Proof-of-concept evidence of immune modulation by blockade of the Phosphatidylinositol 3–kinase (PI3K)-AKT signaling pathway in the phase I dose …
- ZDQ-0620, a Novel Phosphatidylinositol 3–kinase Inhibitor, Inhibits Colorectal Carcinoma Cell Proliferation and Suppresses Angiogenesis by Attenuating …
- Calcium promotes differentiation in ameloblast-like LS8 cells by downregulation of Phosphatidylinositol 3 kinase/protein kinase B pathway
- Endosomal cargo recycling mediated by Gpa1 and Phosphatidylinositol–3–kinase is inhibited by glucose starvation
- Stathmin as a surrogate marker of Phosphatidylinositol–3–kinase pathway activity: Towards precision medicine in HPV-negative head & neck squamous cell …
- Effects of quercetin on autophagy and Phosphatidylinositol 3–kinase/protein kinase b/mammalian target of rapamycin signaling pathway in human prostate cancer PC …
- Modulation of Phosphatidylinositol 3–kinase activity during in vitro oocyte maturation increases the production of bovine blastocysts
- Phosphatidylinositol 3–kinase-independent synthesis of PtdIns (3, 4) P2 by a phosphotransferase
- Phosphatidylinositol 3–kinase gamma participates in nimesulide-induced hepatic damage
- Validated HPLC‐UV method for simultaneous quantification of Phosphatidylinositol 3‐kinase inhibitors, copanlisib, duvelisib and idelalisib, in rat plasma: application …
- 260P A phase I study of copanlisib, a pan-class I Phosphatidylinositol 3–kinase (PI3K) inhibitor, in Chinese patients with relapsed indolent non-Hodgkin lymphoma …
- Structural and functional characterization of Solanum lycopersicum Phosphatidylinositol 3–kinase C2 domain
- Salvianolic acid B attenuates membranous nephropathy by activating renal autophagy via microRNA-145-5p/Phosphatidylinositol 3–kinase/AKT pathway
- … the malignant behavior of esophageal squamous cell carcinoma cells via the homeobox C10/vascular endothelial growth factor A/Phosphatidylinositol 3–kinase/AKT …
- Cytotoxicity of nonylphenol on spermatogonial stem cells via Phosphatidylinositol–3–kinase/protein kinase B/mammalian target of rapamycin pathway
- Participation of Phosphatidylinositol–3 kinase Signalling in Human Chorionic Gonadotropin, Bovine Insulin (B-Insulin) and Human-Insulin-Like Growth Factor …
- Galangin alleviates rheumatoid arthritis in rats by downregulating the Phosphatidylinositol 3–kinase/protein kinase B signaling pathway
- The role of MAP kinases, Phosphatidylinositol 3–kinase, and ceramide in LPS-induced signaling in macrophages
- Casein kinase 1 (CK1) promotes the proliferation and metastasis of glioma cells via the Phosphatidylinositol 3 kinase-matrix metalloproteinase 2 (AKT-MMP2) …
- A first-in-human phase I study of CYH33, a Phosphatidylinositol 3–kinase (PI3K) α selective inhibitor, in patients with advanced solid tumors.
- Endosomal cargo recycling mediated by Gpa1 and Phosphatidylinositol 3–kinase is inhibited by glucose starvation
- … by SRY-related high-mobility-group box 4 (SOX4) accelerates the progression of colon cancer by upregulating Phosphatidylinositol 3–kinase (PI3K)/protein kinase B …
- Long non‐coding RNA TNK2 AS1/microRNA‐125a‐5p axis promotes tumor growth and modulated Phosphatidylinositol 3 kinase/AKT pathway
- Inhibitory effect of PIK-24 on respiratory syncytial virus entry by blocking Phosphatidylinositol–3 kinase signaling
- … and aerobic glycolysis of laryngeal squamous cell carcinoma via regulating reactive oxygen species-mediated Phosphatidylinositol–3–kinase/Protein kinase B …
- Phospho-EGFRTyr992 is synergistically repressed by co-inhibition of histone deacetylase (HDAC) and Phosphatidylinositol 3–kinase (PI3K), which attenuates …
- Schistosoma mansoni Phosphatidylinositol 3 kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling pathway
- … polo-like kinase 4 (PLK4) to inhibit proliferation, migration and invasion of prostate cancer cells through the Phosphatidylinositol 3–kinase (PI3K)/protein kinase B (Akt) …
- 33O A phase I study to evaluate safety, pharmacokinetics (PK), and preliminary efficacy of CYH33, a Phosphatidylinositol 3–kinase α (PI3Kα) inhibitor, in patients (pts) …
- Curcumin Elevates microRNA-183-5p via Cathepsin B-Mediated Phosphatidylinositol 3–kinase/AKT Pathway to Strengthen Lipopolysaccharide-Stimulated …
- Gastrodin protects retinal ganglion cells from ischemic injury by activating Phosphatidylinositol 3–kinase/protein kinase B/nuclear factor erythroid 2-related factor 2 …
- … acid facilitates the apoptosis of chronic myeloid leukemia cells via the microRNA-223/Fms-like tyrosine kinase 3/Phosphatidylinositol–3 kinase/protein kinase B axis
- … of glioma and enhances temozolomide (TMZ) sensitivity via repressing transgelin-2 (TAGLN2) mediated Phosphatidylinositol–3–kinase (PI3K)/protein kinase B (Akt) …
- Inhibition of Phosphatidylinositol 3–kinase (PI3K) enzyme and human skin carcinoma cell growth by Combretum apiculatum Sond.
- Cleavage stimulation factor 2 promotes malignant progression of liver hepatocellular carcinoma by activating Phosphatidylinositol 3′-kinase/protein kinase B …
- Synergism between the Phosphatidylinositol 3–kinase p110β isoform inhibitor AZD6482 and the mixed lineage kinase 3 inhibitor URMC-099 on the blockade …
- … -7-methoxyflavanone protects against H2O2-induced cellular senescence by inducing SIRT1 and inhibiting Phosphatidylinositol 3–kinase/Akt pathway activation
- … antisense RNA 1 augments anti-estrogen resistance in breast cancer cells through the microRNA-363/trefoil factor 1/Phosphatidylinositol 3–kinase/protein kinase B …
- A combination therapy of atypical protein kinase C inhibitors and Phosphatidylinositol–3–kinase inhibitor reduces resistance & invasiveness in renal cell carcinoma …
- Gallic acid promotes the in vitro development of sheep secondary isolated follicles involving the Phosphatidylinositol 3–kinase pathway
- … -induced injury in bronchial epithelial cells via miR-455-3p/phosphatase and tensin homolog axis and Phosphatidylinositol 3–kinase/protein kinase B pathway
- Phosphatidylinositol 3–kinase δ-Specific Inhibitor-Induced Changes in the Ovary and Testis in the Sprague Dawley Rat and Cynomolgus Monkey
- Abstract CT518: First-in-human dose-escalation study of the Phosphatidylinositol 3–kinase α-selective inhibitor HS-10352 in advanced breast cancer
- … A Induces Apoptosis in Human Osteosarcoma MG-63 Cells via Mitochondrial Dysfunction and Phosphatidylinositol 3 kinase/Protein kinase B/Glycogen …
- Identification of Phosphatidylinositol 3–kinase δ (PI3Kδ) Inhibitor: Pharmacophore-based Virtual Screening and Molecular Dynamics Simulation
- Docking studies and antiproliferative activities of 6-(3-aryl-2-propenoyl)-2 (3h)-benzoxazolone derivatives as novel inhibitors of Phosphatidylinositol 3–kinase (PI3Kα)
- Unfractionated heparin attenuates endothelial barrier dysfunction via the Phosphatidylinositol–3 kinase/serine/threonine kinase/nuclear factor kappa-B pathway
- … Pneumococcal Disease. Bedaquiline Suppresses ADP-Mediated Activation of Human Platelets In Vitro via Interference With Phosphatidylinositol 3–kinase
- … 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the Phosphatidylinositol 3–kinase/AKT/mammalian target of …
- Nobiletin Enhances the Chemotherapeutic Efficacy of Docetaxel through Inhibition of Phosphatidylinositol 3–kinase/Protein kinase B and Induction of Apoptosis in …
- … the malignant behavior of non-small cell lung cancer via modulating the E2F family of transcription factor 2/Phosphatidylinositol 3‐kinase/Akt signaling pathway
- … increases pulmonary vein arrhythmogenesis through modulating pulmonary vein electrical and conduction properties via Phosphatidylinositol 3–kinase …
- Quinalizarin Triggers U251 Glioma Cell Apoptosis by Inhibiting Phosphatidylinositol 3–kinase/Protein kinase B/Mammalian Target of Rapamycin Signaling Pathway.
- … Necrosis Factor-α Inhibits Differentiation of Bone Marrow Mesenchymal Stem Cells into Osteoblasts by Inhibiting Phosphatidylinositol 3–kinase (PI3K)/Protein kinase …
- Targeting the Phosphatidylinositol–3–kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways to enhance chemoradiotherapy responsiveness in …
- Uncovering the Potential of Phosphatidylinositol 3–kinase Inhibitors in Cutaneous T-Cell Lymphoma: Insights from High-Throughput In Vitro Screenings
- … Noncoding RNA LINC003121 Inhibits Proliferation and Invasion of Thyroid Cancer Cells by Suppression of the Phosphatidylinositol–3–kinase (PI3K)/Akt Signaling …
- Two Phosphatidylinositol 3–kinase components are involved in interactions between Nicotiana benthamiana and Phytophthora by regulating pathogen effectors and …
- … -1α (SDF-1α) Promotes Growth and Migration of Bone Marrow Stromal Cells (BMSCs) and Gastric Cancer Cells Through Phosphatidylinositol 3–kinase/AKT (PI3K/Akt) …
- Role of Class III Phosphatidylinositol 3–kinase in the Renal Proximal Tubule
- … Mechanism of Extractum Liquidum Drug Loading Materials on Promoting Chronic Wound Tissue Repair Through Phosphatidylinositol 3 kinase/Protein kinase B …
- … Increase Cervical Cancer Cell Proliferation and Migration Through Epidermal Growth Factor Receptor (EGFR)/Phosphatidylinositol 3–kinase (PI3K)/Protein kinase b …
- Quercetin-3-O-β-D-glucuronide inhibits mitochondria pathway-mediated platelet apoptosis via the Phosphatidylinositol–3–kinase/AKT pathway in …
- Phosphatidylinositol–3 kinase activity controls survival and stemness of zebrafish hematopoietic stem/progenitor cells
- … arjuna extract against acetaminophen-induced hepatotoxicity via the regulation of cytochrome P450 2E1, Phosphatidylinositol–3–kinase/protein kinase B
- Eganelisib: Phosphatidylinositol 3–kinase γ (PI3Kγ) inhibitor Treatment of triple-negative breast cancer
- Cryo-EM studies of Phosphatidylinositol–3–kinase related kinase (PIKK) structures from yeast: Transcription-associated protein 1 (Tra1) and Mitosis-entry checkpoint 1 …
- … Factor-β1-Induced Extracellular Matrix Deposition and Reduces Epithelial-Mesenchymal Transition by Regulating The Phosphatidylinositol 3–kinase/Protein kinase B …
- … coenzyme Q attenuates lipopolysaccharide-induced mitochondria-dependent apoptosis in type II alveolar epithelial cells via Phosphatidylinositol 3–kinase/Akt …
- … (BMSCs)-Exosome Carrying MiRNA-312 Inhibits Sevoflurane-Induced Cardiomyocyte Apoptosis Through Activation of Phosphatidylinositol 3–kinase/Protein kinase B …
- Phosphatidylinositol 3–kinase AS A BIOMARKER FOR BREAST CANCER: A REVIEW
- … Bone Marrow Mesenchymal Stem Cells in Inflammatory Environment by Regulating Mammalian Target of Rapamycin/Phosphatidylinositol 3–kinase/Protein kinase B …
- Effect of Silencing Information Regulator on Islet β Cells in High Glucose Environment Through Regulation of Phosphatidylinositol 3 kinase (PI3K)/Protein kinase B …
- miRNA-491-5p Inhibited Cell Proliferation in Human Hepatocellular Carcinoma Through Phosphatidylinositol 3–kinase/Protein kinase B Signaling Pathway
- Vitexin Inhibits the Proliferation and Promotes the Apoptosis of Gastric Cancer Cells via Phosphatidylinositol–3–kinase (PI3K)/Protein kinase B (Akt)/The Mammalian …
- ASO Visual Abstract: Predicting Genomic Alterations of Phosphatidylinositol–3 kinase Signaling in Hepatocellular Carcinoma-A Radiogenomics Study Based on Next …
- Molecular Mechanism of Phosphatidylinositol 3–kinase (PI3K)/Protein kinase B (AKT) Signaling Pathway-Mediated Autophagy in Gastric Cancer
- Natural Compounds as Potential Regulators of the Phosphatidylinositol 3′ kinase (PI3K) Pathway in Breast Cancer
- Valeriana jatamansi Jones inhibits rotavirus-induced diarrhea via Phosphatidylinositol 3–kinase/protein kinase B signaling pathway
- … Differentiation and Osteosynthesis of Bone Marrow Mesenchymal Stem Cells and Alleviates Osteoporosis Through Phosphatidylinositol 3–kinase/Protein kinase B …
- Correction for Bjørgo et al.,“Cross Talk between Phosphatidylinositol 3–kinase and Cyclic AMP (cAMP)-Protein kinase A Signaling Pathways at the Level of a Protein …
- Phosphatidylinositol 3–kinase (PI3K) Inhibitor–Induced Hyperglycemia
- Discovery of highly potent and selective Phosphatidylinositol 3–kinase-δ inhibitors for the treatment of blood cancers and autoimmune diseases
- Role of hydrogen sulfide on expression of Phosphatidylinositol 3 kinase/protein kinase B signal pathway in rats with intestinal ischemia/reperfusion injury
- … Inhibits Hepatic Carcinoma Cell Proliferation, Migration, Invasion and Induces Apoptosis Through Regulating Phosphatidylinositol–3–kinase/Protein kinase B …
- Dexmedetomidine Promotes Spinal Cord Repair and Nerve Regeneration Through Phosphatidylinositol 3–kinase/Protein kinase B/Mammalian Target of Rapamycin …
- B cell antigen receptor expression and Phosphatidylinositol 3–kinase signaling regulate genesis and maintenance of mouse chronic lymphocytic leukemia
- The Inhibition of Phosphatidylinositol–3–kinase in activated T-cells by Hibiscone C derivatives
- microRNA184 Reverses Cisplatin Resistance in Human Ovarian Cancer Cells by Regulating the Phosphatidylinositol–3–kinase (PI3K)/Protein kinase B (AKT) …
- Drugging the phosphoinositide 3–kinase (PI3K) and Phosphatidylinositol 4-kinase (PI4K) family of enzymes for treatment of cancer, immune disorders, and viral …
- Abstract P4-09-04: Prevalence of Phosphatidylinositol–3–kinase (PI3K) pathway alterations and co-alteration of other markers in breast cancer
- Phosphatidylinositol–3–kinase/Protein kinase B Signaling Pathway: A Pivotal Factor for Stimulating Multidrug Resistance in Hepatocellular Carcinoma Cells
- miR-34 Promotes Autophagy and Apoptosis of Spinal Chondrocytes by Mammalian Target of Rapamycin/Phosphatidylinositol–3–kinase/Protein kinase B Signaling
- CLASS II Phosphatidylinositol 3–kinase 2ß IS A NOVEL TARGET FOR THE POTENTIAL DEVELOPMENT OF ANTIVIRAL DRUGS AGAINST THE …
- miR-184 Inhibits Hypertrophic Scar Through Regulating Phosphatidylinositol 3–kinase (PI3K)/Protein kinase B (AKT) Signaling Pathway
- Effect of High-Intensity Interval Training following Ischemia-Reperfusion Injury in Heart on Hand 2 and Phosphatidylinositol–3–kinase Genes in Male Rats
- Mucocutaneous drug reaction after treatment with Phosphatidylinositol–3–kinase inhibitor
- Retracted: Girinimbine Inhibits the Proliferation of Human Ovarian Cancer Cells In Vitro via the Phosphatidylinositol–3–kinase (PI3K)/Akt and the Mammalian Target of …
- Correction: Phosphatidylinositol 3–kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients.
- Corrigendum: The Vacuolar Protein Sorting-38 Subunit of the Arabidopsis Phosphatidylinositol–3–kinase Complex Plays Critical Roles in Autophagy, Endosome …
- Erratum to “Response of Subcutaneous Xenografts of Endometrial Cancer in Nude Mice to Inhibitors of Phosphatidylinositol 3–kinase/Akt and Mitogen-Activated …
- … Cell Proliferation and Atherosclerotic Plaque Formation by Inhibiting Phosphatase and Tensin Homolog (PTEN)/Phosphatidylinositol 3–kinase (PI3K) and Protein …
- MiR-203 Regulates DJ-1/Phosphatase and Tensin Homologue Deleted on Chromosome Ten/Phosphatidylinositol–3 kinase/Protein kinase B Pathway and Affects …
- Homology Modelling and Docking Studies of p85-alpha a subunit of Phosphatidylinositol 3–kinase with Anti-diabetic Compounds
- EPIGENETIC REGULATION OF MICROGLIAL Phosphatidylinositol 3–kinase PATHWAY INVOLVED IN SYNAPTIC PLASTICITY IN RODENTS
- Effect of Electroacupuncture on Expression of Phosphatidylinositol 3 kinase/Glycogen Synthase kinase 3 Alpha Pathway Related Proteins and Senile Plaque …
- Facio-genital dysplasia 5 (FGD5) regulates G-protein coupled receptors (GPCRs) signaling to Phosphatidylinositol 3 kinase (PI3K) pathway
- Neuregulin-1/Phosphatidylinositol 3–kinase Signaling Regulates Expression of Genes Involved in Cellular Cobalamin Uptake and Processing
- DHW-208, a novel Phosphatidylinositol 3–kinase (PI3K) inhibitor, has anti-hepatocellular carcinoma activity through promoting apoptosis and inhibiting …
- … role of miRNA-181 targeting phosphatase and tensin homologue deleted on chromosome ten in the regulation of Phosphatidylinositol–3–kinase/Akt signaling pathway …
- Bacillus subtilis Produces Amino Acids to Stimulate Protein Synthesis in Ruminal Tissue Explants via the Phosphatidylinositol-4, 5-Bisphosphate 3–kinase …
- Repressing Phosphatidylinositol-4, 5-bisphosphate 3–kinase catalytic subunit gamma by microRNA-142-3p restrains the progression of hepatocellular carcinoma
