MTOR (INHIBITOR | INHIBITORS | INHIBITION)
December 8, 2023(AMPK) (ACTIVATOR | ACTIVATORS | ACTIVATION)
December 8, 2023
- Molecular mechanism of nrf2 activation by oxidative stress
- The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress
- Natural Nrf2 activators in diabetes
- Nrf2 activation as target to implement therapeutic treatments
- Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation
- Mechanism of chemical activation of Nrf2
- Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy
- Nrf2 activators as attractive therapeutics for diabetic nephropathy
- Effect of redox modulating NRF2 activators on chronic kidney disease
- Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much?
- CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
- The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
- Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators
- Effect of Nrf2 activators on release of glutathione, cysteinylglycine and homocysteine by human U373 astroglial cells
- Nrf2 signaling in coordinated activation of antioxidant gene expression
- Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia–reperfusion injury
- Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2
- Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet
- Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
- Nrf2 activation: a potential strategy for the prevention of acute mountain sickness
- Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators
- NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells
- Sulforaphane protects against cardiovascular disease via Nrf2 activation
- Nrf2 activation prevents cadmium-induced acute liver injury
- Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation
- The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
- Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis
- Nrf2 activation protects the liver from ischemia/reperfusion injury in mice
- Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells
- Keap1‐Nrf2 activation in the presence and absence of DJ‐1
- Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
- Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis–related fibrosis in a dietary rat model
- miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells
- Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy
- Nrf2 activation protects against solar-simulated ultraviolet radiation in mice and humans
- Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide
- A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62
- Effect of graded Nrf2 activation on phase-I and-II drug metabolizing enzymes and transporters in mouse liver
- Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation
- Abbott boosts investment in NRF2 activators for reducing oxidative stress
- Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells
- Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice
- Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress
- Identification of ketoconazole as an AhR-Nrf2 activator in cultured human keratinocytes: the basis of its anti-inflammatory effect
- Activation of the Nrf2–ARE signaling pathway: a promising strategy in cancer prevention
- Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation
- Tert-butylhydroquinone induces mitochondrial oxidative stress causing Nrf2 activation
- Transcriptional regulation of the antioxidant response element: activation by Nrf2 and repression by MafK
- Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: role of Nrf2 activation
- … -mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 …
- The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation
- The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells
- Redox activation of Nrf2 & NF-κB: a double end sword?
- Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify …
- Activation of the Nrf2/antioxidant response pathway increases IL‐8 expression
- Adaptive response to GSH depletion and resistance to l-buthionine-(S,R)-sulfoximine: involvement of Nrf2 activation
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
- Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents
- Th2 skewing by activation of Nrf2 in CD4+ T cells
- Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes
- Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
- Anti-Atherogenic Effect of Laminar Shear Stress via Nrf2 Activation
- T lymphocyte–specific activation of Nrf2 protects from AKI
- Skin resistance to oxidative stress induced by resveratrol: from Nrf2 activation to GSH biosynthesis
- Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages
- Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state
- Identification of Chromomoric Acid CI as an Nrf2 Activator in Chromolaena odorata
- Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species
- … protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element: degradation of Nrf2 by the 26 S …
- Nrf2 activation is associated with Z-DNA formation in the human HO-1 promoter
- Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR‐dependent motor neuron apoptosis
- Nrf2 activators provide neuroprotection against 6‐hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures
- Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation
- Antioxidant and anti-inflammatory activities of a natural compound, shizukahenriol, through Nrf2 activation
- Nrf2 activation involves an oxidative-stress independent pathway in tetrafluoroethylcysteine-induced cytotoxicity
- Reporter protein complementation imaging assay to screen and study Nrf2 activators in cells and living animals
- Caffeic acid phenethyl ester-mediated Nrf2 activation and IκB kinase inhibition are involved in NFκB inhibitory effect: structural analysis for NFκB inhibition
- The Nrf2 activator oltipraz also activates the constitutive androstane receptor
- Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression
- Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H‐1, 2‐dithiole‐3‐thione
- Hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction
- Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis
- TNF mediates the sustained activation of Nrf2 in human monocytes
- KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma
- Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro
- Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathway
- BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis
- Discovery and modification of in vivo active Nrf2 activators with 1, 2, 4-oxadiazole core: hits identification and structure–activity relationship study
- Nrf2 activators modulate oxidative stress responses and bioenergetic profiles of human retinal epithelial cells cultured in normal or high glucose conditions
- Nrf2 activation attenuates both orthodontic tooth movement and relapse
- Arsenic‐mediated activation of the Nrf2‐Keap1 antioxidant pathway
- Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2
- Transcription factor Nrf2 activation by deltamethrin in PC12 cells: involvement of ROS
- Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway
- Inhibition of liver fibrosis by solubilized coenzyme Q10: role of Nrf2 activation in inhibiting transforming growth factor-β1 expression
- NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson’s disease
- Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice
- Nrf2 activation by sulforaphane restores the age-related decrease of TH1 immunity: Role of dendritic cells
- Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation
- Is ozone pre-conditioning effect linked to Nrf2/EpRE activation pathway in vivo? A preliminary result
- The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1
- Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells
- A protective mechanism of licorice (Glycyrrhiza uralensis): isoliquiritigenin stimulates detoxification system via Nrf2 activation
- PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress
- Activation of Nrf2 in defense against cadmium-induced oxidative stress
- Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression
- MicroRNA-200a controls Nrf2 activation by target Keap1 in hepatic stellate cell proliferation and fibrosis
- Activation of transcription factor Nrf2 by hepatitis C virus induces the cell-survival pathway
- Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species
- Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis
- Activation of Nrf2–ARE pathway in brain after traumatic brain injury
- The chalcone compound isosalipurposide (ISPP) exerts a cytoprotective effect against oxidative injury via Nrf2 activation
- Endothelial Nrf2 activation: a new target for resveratrol?
- Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy
- Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
- EGFR mediates astragaloside IV-induced Nrf2 activation to protect cortical neurons against in vitro ischemia/reperfusion damages
- … to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response …
- Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer
- Reoxygenation‐specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia‐reperfusion injury
- Activation of Nrf2 protects against triptolide-induced hepatotoxicity
- New insights into the pathogenesis of preeclampsia–the role of nrf2 activators and their potential therapeutic impact
- Activation of Nrf2 in keratinocytes causes chloracne (MADISH)‐like skin disease in mice
- Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1–Cul3 interaction
- Role of Nrf2 activation and NF-κB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice
- ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells
- Translational control of nrf2 protein in activation of antioxidant response by oxidants
- Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia
- Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
- Lutein suppresses inflammatory responses through Nrf2 activation and NF‐κB inactivation in lipopolysaccharide‐stimulated BV‐2 microglia
- Nrf2 activation promotes keratinocyte survival during early skin carcinogenesis via metabolic alterations
- Photothrombosis-induced infarction of the mouse cerebral cortex is not affected by the Nrf2-activator sulforaphane
- Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophillic phase II inducers
- Screening of natural compounds as activators of the keap1-nrf2 pathway
- LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT
- Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy
- KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells
- tert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation
- Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover
- Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2
- Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis
- Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
- Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes
- The Nrf2 activator, tBHQ, differentially affects early events following stimulation of Jurkat cells
- AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells
- Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
- Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells
- Nrf2 activation in astrocytes contributes to spinal cord ischemic tolerance induced by hyperbaric oxygen preconditioning
- Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway
- Activation of coupled Ah receptor and Nrf2 gene batteries by dietary phytochemicals in relation to chemoprevention
- Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts
- Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation
- Chemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease prevention
- NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation
- Sulforaphane and α-Lipoic Acid Upregulate the Expression of the π Class of Glutathione S-Transferase through c-Jun and Nrf2 Activation
- Activation of Nrf2 by H2O2: de novo synthesis versus nuclear translocation
- Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell‐cycle control and apoptosis
- Activation of Nrf2-mediated oxidative stress response in macrophages by hypochlorous acid
- Dietary Nrf2 activators inhibit atherogenic processes
- Bilirubin mediated oxidative stress involves antioxidant response activation via Nrf2 pathway
- Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress
- Thyroid Hormone Administration Induces Rat Liver Nrf2 Activation: Suppression by N-Acetylcysteine Pretreatment
- Characterization of Nrf2 activation and heme oxygenase-1 expression in NIH3T3 cells exposed to aqueous extracts of cigarette smoke
- The effect of Nrf2 pathway activation on human pancreatic islet cells
- Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation
- Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para-and ortho-hydroquinones
- Age-Associated Vascular Oxidative Stress, Nrf2 Dysfunction, and NF-κB Activation in the Nonhuman Primate Macaca mulatta
- Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling
- Genetic activation of Nrf2 protects against fasting-induced oxidative stress in livers of mice
- Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning
- … of a stable antioxidant response element–driven reporter gene cell line and its use to show redox-dependent activation of Nrf2 by cancer chemotherapeutic agents
- Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism
- Hepatitis B virus induces expression of antioxidant response element-regulated genes by activation of Nrf2
- Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses
- NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α
- Hsp90 interaction with INrf2 (Keap1) mediates stress-induced Nrf2 activation
- Lithium protects against paraquat neurotoxicity by NRF2 activation and miR-34a inhibition in SH-SY5Y cells
- A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia
- Antioxidant effects of Lactobacillus plantarum via activation of transcription factor Nrf2
- Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha
- Resveratrol dimers, nutritional components in grape wine, are selective ROS scavengers and weak Nrf2 activators
- Nrf2 is essential for cholesterol crystal‐induced inflammasome activation and exacerbation of atherosclerosis
- Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2
- Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …
- Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress
- Dieckol enhances the expression of antioxidant and detoxifying enzymes by the activation of Nrf2–MAPK signalling pathway in HepG2 cells
- Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells
- Bioactive food components prevent carcinogenic stress via Nrf2 activation in BRCA1 deficient breast epithelial cells
- NRF2 pathway activation and adjuvant chemotherapy benefit in lung squamous cell carcinoma
- Temozolomide and irradiation combined treatment-induced Nrf2 activation increases chemoradiation sensitivity in human glioblastoma cells
- Intracellular accumulation of subviral HBsAg particles and diminished Nrf2 activation in HBV genotype G expressing cells lead to an increased ROI level
- Vitamin A supplementation alleviates extrahepatic cholestasis liver injury through Nrf2 activation
- Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients
- Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma
- … of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2
- Estrogen increases Nrf2 activity through activation of the PI3K pathway in MCF-7 breast cancer cells
- Activation of Nrf2 by dimethyl fumarate improves vascular calcification
- Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole
- Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling
- Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity
- Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation
- Activation of Nrf2-ARE signal pathway protects the brain from damage induced by epileptic seizure
- Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge
- Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy
- Bakuchiol is a phenolic isoprenoid with novel enantiomer-selective anti-influenza A virus activity involving Nrf2 activation
- Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells
- Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC)
- Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1
- Neohesperidin Dihydrochalcone versus CCl4-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation
- Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis
- Activation of Nrf2 by cadmium and its role in protection against cadmium-induced apoptosis in rat kidney cells
- … subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene …
- Pharmacodynamics of ginsenosides: antioxidant activities, activation of Nrf2, and potential synergistic effects of combinations
- The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis
- Geraniol attenuates oxidative stress by Nrf2 activation in diet-induced experimental atherosclerosis
- Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells
- Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury
- Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells
- (−)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells
- … of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR‐32 …
- Hemin-induced activation of the thioredoxin gene by Nrf2: a differential regulation of the antioxidant responsive element by a switch of its binding factors
- Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth
- Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2
- Identification and characterization of PERK activators by phenotypic screening and their effects on NRF2 activation
- Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes
- Chemopreventive role of anthocyanins in atherosclerosis via activation of Nrf2–ARE as an indicator and modulator of redox
- Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson’s disease
- Activation of endothelial nitric oxide synthase by dietary isoflavones: role of NO in Nrf2-mediated antioxidant gene expression
- Silica nanoparticles induce oxidative stress, inflammation, and endothelial dysfunction in vitro via activation of the MAPK/Nrf2 pathway and nuclear factor-κB signaling
- Cancer cell growth is differentially affected by constitutive activation of NRF2 by KEAP1 deletion and pharmacological activation of NRF2 by the synthetic …
- … , a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling
- Effects of different exercise durations on Keap1-Nrf2-ARE pathway activation in mouse skeletal muscle
- Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal
- The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia–reperfusion injury in mice
- Activation of the Nrf2-regulated antioxidant cell response inhibits HEMA-induced oxidative stress and supports cell viability
- Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2-dependent transcriptional activation
- Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62 …
- Resveratrol protects primary rat hepatocytes against oxidative stress damage:: Activation of the Nrf2 transcription factor and augmented activities of antioxidant …
- Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia …
- Imine resveratrol analogues: molecular design, Nrf2 activation and SAR analysis
- Antiarrhythmic effect of lithium in rats after myocardial infarction by activation of Nrf2/HO-1 signaling
- The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression
- Impaired activation of the Nrf2-ARE signaling pathway undermines H2O2-induced oxidative stress response: a possible mechanism for melanocyte …
- Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2
- Nrf2 activation diminishes during adipocyte differentiation of ST2 cells
- Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of …
- Estrogen Receptor and PI3K/Akt Signaling Pathway Involvement in S-(-)Equol-Induced Activation of Nrf2/ARE in Endothelial Cells
- Ethyl pyruvate-mediated Nrf2 activation and hemeoxygenase 1 induction in astrocytes confer protective effects via autocrine and paracrine mechanisms
- Constitutive activation of the Nrf2/Keap1 pathway in insecticide-resistant strains of Drosophila
- Antioxidant effects of diallyl trisulfide on high glucose-induced apoptosis are mediated by the PI3K/Akt-dependent activation of Nrf2 in cardiomyocytes
- Naringenin attenuates CCl4‐induced hepatic inflammation by the activation of an Nrf2‐mediated pathway in rats
- Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 …
- Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial cells
- Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia‐induced activation of HIF‐1α
- Induction of antioxidant and detoxification response by oxidants in cardiomyocytes: evidence from gene expression profiling and activation of Nrf2 transcription factor
- Kaposi’s sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with …
- Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation
- Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB
- Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate …
- PI3K/Akt pathway mediates Nrf2/ARE activation in human L02 hepatocytes exposed to low-concentration HBCDs
- Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2–ARE pathway
- Toll-like receptor signaling induces Nrf2 pathway activation through p62-triggered Keap1 degradation
- Oxidative stress and dysregulated Nrf2 activation in the pathogenesis of schizophrenia
- Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in Caenorhabditis elegans
- HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction
- Z‐Ligustilide inhibits benzo (a) pyrene‐induced CYP1A1 upregulation in cultured human keratinocytes via ROS‐dependent Nrf2 activation
- … are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation
- Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response
- Characterization of RA839, a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling
- Decreased lectin-like oxidized LDL receptor 1 (LOX-1) and low Nrf2 activation in placenta are involved in preeclampsia
- α-Lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia/reperfusion injury through activation of PI3K/Akt/Nrf2 pathway
- Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells
- Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt
- Sulforaphane protects rodent retinas against ischemia-reperfusion injury through the activation of the Nrf2/HO-1 antioxidant pathway
- Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation …
- Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin
- Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder
- Nrf2-dependent activation of the antioxidant responsive element by tert-butylhydroquinone is independent of oxidative stress in IMR-32 human neuroblastoma cells
- Lycopene attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway
- Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats
- Preconditioning by sesquiterpene lactone enhances H2O2-induced Nrf2/ARE activation
- N-acetylcysteine protects against liver injure induced by carbon tetrachloride via activation of the Nrf2/HO-1 pathway
- Activation of the UPR protects against cigarette smoke-induced RPE apoptosis through up-regulation of Nrf2
- Is there a sweet spot for Nrf2 activation in the treatment of diabetic kidney disease?
- Effect of diallyl sulfide on in vitro and in vivo Nrf2-mediated pulmonic antioxidant enzyme expression via activation ERK/p38 signaling pathway
- … inhibits the tumor necrosis factor-α-induced expression of cell adhesion molecules in endothelial cells by suppressing NF-κB activation: Effects upon IκB and Nrf2
- Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol-and CCl4-induced hepatic fibrosis
- Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity
- Sulforaphane alleviates muscular dystrophy in mdx mice by activation of Nrf2
- A somatic mutation of the KEAP1 gene in malignant melanoma is involved in aberrant NRF2 activation and an increase in intrinsic drug resistance
- Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition
- Garlic attenuates cardiac oxidative stress via activation of PI3K/AKT/Nrf2-Keap1 pathway in fructose-fed diabetic rat
- Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2
- Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans
- Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated Wistar …
- Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper‐ and o‐quinone‐dependent Nrf2 activation by a catechol …
- Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model
- Caffeic acid phenethyl ester activation of Nrf2 pathway is enhanced under oxidative state: structural analysis and potential as a pathologically targeted therapeutic …
- Forsythiaside inhibits cigarette smoke-induced lung inflammation by activation of Nrf2 and inhibition of NF-κB
- Drug resistance associates with activation of Nrf2 in MCF‐7/DOX cells, and wogonin reverses it by down‐regulating Nrf2‐mediated cellular defense response
- The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression
- Protection from cyanide‐induced brain injury by the Nrf2 transcriptional activator carnosic acid
- Activation of the Nrf2–ARE pathway in muscle and spinal cord during ALS-like pathology in mice expressing mutant SOD1
- The role of the catecholic and the electrophilic moieties of caffeic acid in Nrf2/Keap1 pathway activation in ovarian carcinoma cell lines
- Cadmium induced cardiac oxidative stress in rats and its attenuation by GSP through the activation of Nrf2 signaling pathway
- Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells
- Participation of protein kinase C in the activation of Nrf2 signaling by ischemic preconditioning in the isolated rabbit heart
- A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response
- Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis (cyanoenone), a highly potent Nrf2 activator with a reversible covalent …
- Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation
- Oleuropein and oleacein may restore biological functions of endothelial progenitor cells impaired by angiotensin II via activation of Nrf2/heme oxygenase-1 pathway
- 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation
- Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC α/βII by Gymnasterkoreayne B
- Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells
- EGFR-activated signaling and actin remodeling regulate cyclic stretch–induced NRF2-ARE activation
- Dietary Lycium barbarum Polysaccharide Induces Nrf2/ARE Pathway and Ameliorates Insulin Resistance Induced by High-Fat via Activation of PI3K/AKT …
- Nrf2–ARE activator carnosic acid decreases mitochondrial dysfunction, oxidative damage and neuronal cytoskeletal degradation following traumatic brain injury in …
- … acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal …
- MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human …
- Activation of mouse Pi-class glutathione S-transferase gene by Nrf2 (NF-E2-related factor 2) and androgen
- Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation
- Protective Effect of the Fruit Hull of Gleditsia sinensis on LPS-Induced Acute Lung Injury Is Associated with Nrf2 Activation
- Synthesis and bioevaluation of a series of α-pyrone derivatives as potent activators of Nrf2/ARE pathway (part I)
- Isothiocyanates protect against oxidized LDL‐induced endothelial dysfunction by upregulating Nrf2‐dependent antioxidation and suppressing NFκB activation
- Carbon monoxide mediates heme oxygenase 1 induction via Nrf2 activation in hepatoma cells
- Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and …
- Nrf2 activation as a future target of therapy for chronic diseases
- 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2
- Increased glutathione synthesis following Nrf2 activation by vanadyl sulfate in human chang liver cells
- Activation of NRF2 signaling in HEK293 cells by a first‐in‐class direct KEAP1‐NRF2 inhibitor
- Activation of the Nrf2 defense pathway contributes to neuroprotective effects of phloretin on oxidative stress injury after cerebral ischemia/reperfusion in rats
- Eriodictyol protects against H2O2-induced neuron-like PC12 cell death through activation of Nrf2/ARE signaling pathway
- PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation
- tBHQ inhibits LPS-induced microglial activation via Nrf2-mediated suppression of p38 phosphorylation
- Administration of the Nrf2–ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo
- Selenite cataracts: activation of endoplasmic reticulum stress and loss of Nrf2/Keap1-dependent stress protection
- Oroxylin A exerts anti-inflammatory activity on lipopolysaccharide-induced mouse macrophage via Nrf2/ARE activation
- Nitroxide delivery system for Nrf2 activation and skin protection
- Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a …
- Sustained NRF2 activation in hereditary leiomyomatosis and renal cell cancer (HLRCC) and in hereditary tyrosinemia type 1 (HT1)
- MyD88 is a mediator for the activation of Nrf2
- Carnosic acid, a catechol‐type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S‐alkylation of …
- Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes
- Dimethoxycurcumin, a synthetic curcumin analogue, induces heme oxygenase-1 expression through Nrf2 activation in RAW264. 7 macrophages
- The inhibitory effects of Geranium thunbergii on interferon-γ-and LPS-induced inflammatory responses are mediated by Nrf2 activation
- Epigallocatechin-3-gallate prevents TNF-α-induced NF-κB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells
- Chromium (VI)‐induced oxidative stress and apoptosis is reduced by garlic and its derivative S‐allylcysteine through the activation of Nrf2 in the hepatocytes of Wistar …
- Activation of the Nrf2-ARE pathway attenuates hyperglycemia-mediated injuries in mouse podocytes
- … -derived superoxide by notoginsenoside R1 protects against cerebral ischemia–reperfusion injury through estrogen receptor-dependent activation of Akt/Nrf2 …
- Continuous activation of Nrf2 and its target antioxidant enzymes leads to arsenite-induced malignant transformation of human bronchial epithelial cells
- Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system
- Chitooligosaccharides inhibit ethanol-induced oxidative stress via activation of Nrf2 and reduction of MAPK phosphorylation
- … adriamycin-induced cardiotoxicity by improving endothelial dysfunction from oxidative stress via upregulating the Nrf2-ARE pathway through the activation of akt
- Luteolin, a bioflavonoid inhibits Azoxymethane-induced colorectal cancer through activation of Nrf2 signaling
- Grape seed proanthocyanidin extract ameliorates diabetic bladder dysfunction via the activation of the Nrf2 pathway
- Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition
- Auranofin, a gold (I)-containing antirheumatic compound, activates Keap1/Nrf2 signaling via Rac1/iNOS signal and mitogen-activated protein kinase activation
- Nrf2/HO‐1 pathway activation by manganese is associated with reactive oxygen species and ubiquitin–proteasome pathway, not MAPKs signaling
- … Latifolin Isolated from MeOH Extract of Dalbergia odorifera Attenuates Inflammatory Responses by Inhibiting NF‐κB Activation via Nrf2‐Mediated Heme Oxygenase …
- Protective effects of diallyl disulfide on carbon tetrachloride‐induced hepatotoxicity through activation of Nrf2
- S [+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis
- Redox mechanisms involved in the selective activation of Nrf2-mediated resistance versus p53-dependent apoptosis in adenocarcinoma cells
- Pharmacological activation of Nrf2 pathway improves pancreatic islet isolation and transplantation
- Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury
- Activation of Nrf2 target enzymes conferring protection against oxidative stress in PC12 cells by ginger principal constituent 6-shogaol
- The antioxidative potential of farrerol occurs via the activation of Nrf2 mediated HO-1 signaling in RAW 264.7 cells
- Nrf2 expression and activity in human T lymphocytes: stimulation by T cell receptor activation and priming by inorganic arsenic and tert-butylhydroquinone
- … of dimerumic acid on hepatic fibrosis caused from carboxymethyl-lysine (CML) by attenuating oxidative stress depends on Nrf2 activation in hepatic stellate cells …
- Activation of the Nrf2 pathway by inorganic arsenic in human hepatocytes and the role of transcriptional repressor Bach1
- The NRF2 activation and antioxidative response are not impaired overall during hyperoxia-induced lung epithelial cell death
- Isolation, identification, and biological evaluation of Nrf2-ARE activator from the leaves of green perilla (Perilla frutescens var. crispa f. viridis)
- Anti-inflammatory efficacy of dexamethasone and Nrf2 activators in the CNS using brain slices as a model of acute injury
- Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation
- Enhanced CD36 expression changes the role of Nrf2 activation from anti-atherogenic to pro-atherogenic in apoE-deficient mice
- Alpha-lipoic acid regulates heme oxygenase gene expression and nuclear Nrf2 activation as a mechanism of protection against arsenic exposure in HepG2 cells
- Extracellular DNA oxidation stimulates activation of NRF2 and reduces the production of ROS in human mesenchymal stem cells
- Ethanol extract of peanut sprout induces Nrf2 activation and expression of antioxidant and detoxifying enzymes in human dermal fibroblasts: Implication for its …
- ent-kaur-16-en-19-oic Acid, isolated from the roots of Aralia continentalis, induces activation of Nrf2
- Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca2+ influx activation in mouse pancreatic acinar cells
- Activation of Nrf2-ARE signal pathway in hippocampus of amygdala kindling rats
- Bruton’s tyrosine kinase is required for TLR-dependent heme oxygenase-1 gene activation via Nrf2 in macrophages
- Ginsenoside Rb1 improves postoperative fatigue syndrome by reducing skeletal muscle oxidative stress through activation of the PI3K/Akt/Nrf2 pathway in aged rats
- Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells
- Shikonin inhibits oxidized LDL-induced monocyte adhesion by suppressing NFκB activation via up-regulation of PI3K/Akt/Nrf2-dependent antioxidation in EA. hy926 …
- Attenuation of NF-κB and activation of Nrf2 signaling by 1, 2, 4-triazine derivatives, protects neuron-like PC12 cells against apoptosis
- Protective effects of erythropoietin in traumatic spinal cord injury by inducing the Nrf2 signaling pathway activation
- Melatonin antagonizes Mn-induced oxidative injury through the activation of keap1–Nrf2–ARE signaling pathway in the striatum of mice
- Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation
- The activation of Nrf2 and its downstream regulated genes mediates the antioxidative activities of xueshuan xinmaining tablet in human umbilical vein …
- Deprenyl prevents MPP+-induced oxidative damage in PC12 cells by the upregulation of Nrf2-mediated NQO1 expression through the activation of PI3K/Akt and Erk
- Histone acetyltransferase MOZ acts as a co-activator of Nrf2–MafK and induces tumour marker gene expression during hepatocarcinogenesis
- Eckol enhances heme oxygenase-1 expression through activation of Nrf2/JNK pathway in HepG2 cells
- Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response
- … effects of β-hydroxyisovalerylshikonin in BV2 microglia are mediated through suppression of the PI3K/Akt/NF-kB pathway and activation of the Nrf2/HO-1 pathway
- Antioxidant effects of hydrogen sulfide on left ventricular remodeling in smoking rats are mediated via PI3K/Akt-dependent activation of Nrf2
- The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase …
- Gold nanoparticles induce heme oxygenase-1 expression through Nrf2 activation and Bach1 export in human vascular endothelial cells
- Reactivity of Chemical Sensitizers Toward Amino Acids In Cellulo Plays a Role in the Activation of the Nrf2-ARE Pathway in Human Monocyte Dendritic Cells and the …
- 3, 4, 5-Trihydroxycinnamic acid inhibits lipopolysaccharide (LPS)-induced inflammation by Nrf2 activation in vitro and improves survival of mice in LPS-induced …
- Role of Nrf2 in neurodegenerative diseases and recent progress of its activators
- Nelumbo nucifera leaves protect hydrogen peroxide-induced hepatic damage via antioxidant enzymes and HO-1/Nrf2 activation
- Activation of Nrf2-antioxidant response element mediated glutamate cysteine ligase expression in hepatoma cell line by homocysteine
- Chitooligosaccharides Attenuate Cu2+-Induced Cellular Oxidative Damage and Cell Apoptosis Involving Nrf2 Activation
- 1, 5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes
- Akt and ERK/Nrf2 activation by PUFA oxidation-derived aldehydes upregulates FABP4 expression in human macrophages
- Activation of the Nrf2-ARE pathway in hepatocytes protects against steatosis in nutritionally induced non-alcoholic steatohepatitis in mice
- Prunella vulgaris Suppresses HG-Induced Vascular Inflammation via Nrf2/HO-1/eNOS Activation
- Nrf2 activation in the liver of rats subjected to a preconditioning sub-chronic iron protocol
- … of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1
- P90RSK and Nrf2 activation via MEK1/2-ERK1/2 pathways mediated by notoginsenoside R2 to prevent 6-hydroxydopamine-induced apoptotic death in SH …
- Cardioprotective role of P38 MAPK during myocardial infarction via parallel activation of α‐crystallin B and Nrf2
- A novel kavalactone derivative protects against H2O2-induced PC12 cell death via Nrf2/ARE activation
- … to diesel exhaust particle extracts (DEPe) impairs some polarization markers and functions of human macrophages through activation of AhR and Nrf2
- Antroquinonol differentially modulates T cell activity and reduces interleukin‐18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis
- Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene …
- Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by α-lipoic acid in human leukemia HL-60 cells
- Oleanolic acid attenuates obstructive cholestasis in bile duct-ligated mice, possibly via activation of NRF2-MRPs and FXR antagonism
- Antioxidative stress effect of phosphoserine dimers is mediated via activation of the Nrf2 signaling pathway
- Ketamine reduces LPS-induced HMGB1 via activation of the Nrf2/HO-1 pathway and NF-κB suppression
- … AITC attenuate methylglyoxal-induced PPARγ phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation
- Panaxatriol saponins attenuated oxygen-glucose deprivation injury in PC12 cells via activation of PI3K/Akt and Nrf2 signaling pathway
- Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a …
- Eriodictyol Attenuates β-amyloid 25–35 peptide-induced oxidative cell death in primary cultured neurons by activation of Nrf2
- 3, 4, 5-Trihydroxycinnamic acid inhibits lipopolysaccharide-induced inflammatory response through the activation of Nrf2 pathway in BV2 microglial cells
- Synthesis of piperlongumine analogues and discovery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators as potential neuroprotective agents
- … response and enhancement of PC12 cell tolerance by lipopolysaccharide primarily through the upregulation of glutathione S-transferase A3 via Nrf2 activation
- A kavalactone derivative inhibits lipopolysaccharide-stimulated iNOS induction and NO production through activation of Nrf2 signaling in BV2 microglial cells
- Dangkwisoo-san, an herbal medicinal formula, ameliorates acute lung inflammation via activation of Nrf2 and suppression of NF-κB
- Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
- … hydrogen sulfide modulator, S-propargyl-cysteine, on high glucose-induced apoptosis in cardiomyocytes: a novel mechanism mediated by the activation of Nrf2
- Of mice, rats, and men: could Nrf2 activation protect against aflatoxin heptocarcinogenesis in humans?
- Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans: activation of the Nrf2 signaling pathway and prolongation of lifespan
- Icaritin attenuates cigarette smoke-mediated oxidative stress in human lung epithelial cells via activation of PI3K-AKT and Nrf2 signaling
- Nrf2 Activation Enhances Biliary Excretion of Sulfobromophthalein by Inducing Glutathione-S-Transferase Activity
- Activation of the transcription factor Nrf2 in macrophages, Caco-2 cells and intact human gut tissue by Maillard reaction products and coffee
- Nrf2, not the estrogen receptor, mediates catechol estrogen-induced activation of the antioxidant responsive element
- Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products
- Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 …
- … -induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2–Cul3–Rbx1 complex to allow normal Nrf2 activation and …
- Activation of Nrf2/HO-1signaling pathway involves the anti-inflammatory activity of magnolol in Porphyromonas gingivalis lipopolysaccharide-stimulated mouse RAW …
- Autophagy deficiency diminishes indomethacin-induced intestinal epithelial cell damage through activation of the ERK/Nrf2/HO-1 pathway
- Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1
- Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5, 7-Dihydroxychromone: Activation of the Nrf2/ARE pathway
- Pro-oxidants ameliorate radiation-induced apoptosis through activation of the calcium–ERK1/2–Nrf2 pathway
- Involvement of activation of the Nrf2/ARE pathway in protection against 6-OHDA-induced SH-SY5Y cell death by α-iso-cubebenol
- Induction of activation of the antioxidant response element and stabilization of Nrf2 by 3-(3-pyridylmethylidene)-2-indolinone (PMID) confers protection against …
- Inhibition of LXRα-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation
- … water concentrate and its active component shikimic acid against hydroperoxide mediated oxidative stress through suppression of NF-κB and activation of Nrf2 …
- Effect of glutathione depletion on Nrf2/ARE activation by deltamethrin in PC12 Cells
- Norepinephrine provides short-term neuroprotection against Aβ1–42 by reducing oxidative stress independent of Nrf2 activation
- The role of sulfhydryl reactivity of small molecules for the activation of the KEAP1/NRF2 pathway and the heat shock response
- Comment on hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 …
- Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers
- Glucose reintroduction triggers the activation of Nrf2 during experimental ischemia reperfusion
- Novel Nrf2/ARE Activator, trans-Coniferylaldehyde, Induces a HO-1-Mediated Defense Mechanism through a Dual p38α/MAPKAPK-2 and PK-N3 Signaling Pathway
- Inhibition of neointimal formation by trans‐resveratrol: Role of phosphatidyl inositol 3‐kinase‐dependent Nrf2 activation in heme oxygenase‐1 induction
- Cordyceps sinensis Increases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung Epithelial Cells
- Activation of NRF2 pathway in spleen, thymus as well as peripheral blood mononuclear cells by acute arsenic exposure in mice
- Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activation of the Nrf2 transcription factor and selective cytotoxic activity
- Taurine chloramine induces heme oxygenase-1 expression via Nrf2 activation in murine macrophages
- Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)
- Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway
- Activation of Nrf2 Is Required for Up-Regulation of the π Class of Glutathione S-Transferase in Rat Primary Hepatocytes with l-Methionine Starvation
- … -induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation
- Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE …
- Rat H9c2 cardiac myocytes are sensitive to arsenite due to a modest activation of transcription factor Nrf2
- Irradiation inhibits the maturation and mineralization of osteoblasts via the activation of Nrf2/HO-1 pathway
- DHEA alleviates oxidative stress of muscle cells via activation of Nrf2 pathway
- Squid ink polysaccharide reduces cyclophosphamide-induced testicular damage via Nrf2/ARE activation pathway in mice
- Chamomile confers protection against hydrogen peroxide‐induced toxicity through activation of nrf2‐mediated defense response
- Fragrant unsaturated aldehydes elicit activation of the Keap1/Nrf2 system leading to the upregulation of thioredoxin expression and protection against oxidative stress
- New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase
- CYP2C8-derived epoxyeicosatrienoic acids decrease oxidative stress-induced endothelial apoptosis in development of atherosclerosis: role of Nrf2 activation
- Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway
- … of 7, 8-dihydroxyflavone against oxidative stress are mediated by the upregulation of Nrf2-dependent HO-1 expression through the activation of the PI3K/Akt …
- The combination of the active principles of Podophyllum hexandrum supports early recovery of the gastrointestinal system via activation of Nrf2-HO-1 signaling and …
- Lipopolysaccharide preconditioning attenuates neuroapoptosis and improves functional recovery through activation of Nrf2 in traumatic spinal cord injury rats
- MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis
- Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe
- … than resveratrol in preventing azoxymethane (AOM)-induced colon tumorigenesis via activation of the NF-E2-related factor 2 (Nrf2)-mediated antioxidant signaling …
- Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model
- … grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-κB and STAT1 and activation of Nrf2/ARE-mediated heme …
- Dwindling of cardio damaging effect of isoproterenol by Punica granatum L. peel extract involve activation of nitric oxide-mediated Nrf2/ARE signaling pathway and …
- Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt/ERK1/2/Nrf2 signaling
- Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation
- Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2
- Lycopene improves activation of antioxidant system and Nrf2/HO-1 pathway of muscle in rainbow trout (Oncorhynchus mykiss) with different stocking densities
- … ‑tocotrienol prevents 5‑FU‑induced reactive oxygen species production in human oral keratinocytes through the stabilization of 5‑FU‑induced activation of Nrf2
- Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling
- Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced …
- An IκBα phosphorylation inhibitor induces heme oxygenase-1 (HO-1) expression through the activation of reactive oxygen species (ROS)–Nrf2–ARE signaling and …
- Bucillamine induces glutathione biosynthesis via activation of the transcription factor Nrf2
- Activation of alveolar macrophages with interferon-γ promotes antioxidant defenses via the Nrf2-ARE pathway
- Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice
- Discovery of oxime-bearing naphthalene derivatives as a novel structural type of Nrf2 activators
- Activation of Nrf2/Keap1 signaling and autophagy induction against oxidative stress in heart in iron deficiency
- Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide
- Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways
- 15‐Deoxy‐Δ12,14‐prostaglandin J2 Induces Upregulation of Multidrug Resistance‐Associated Protein 1 via Nrf2 Activation in Human Breast Cancer Cells
- 15-Deoxy-Δ12, 14-prostaglandin J2 modulates manganese-induced activation of the NF-κB, Nrf2, and PI3K pathways in astrocytes
- Highly Potent Activation of Nrf2 by Topical Tricyclic Bis(Cyano Enone): Implications for Protection against UV Radiation during Thiopurine Therapy
- Reactive sulfur species-mediated activation of the Keap1–Nrf2 pathway by 1, 2-naphthoquinone through sulfenic acids formation under oxidative stress
- Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells: role of p38 kinase and Nrf2 transcription factor
- Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals
- Nrf2 and HSF-1 pathway activation via hydroquinone-based proelectrophilic small molecules is regulated by electrochemical oxidation potential
- Astaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase II enzymes through activation of PI3K/Akt
- Pyrroloquinoline quinone rescues hippocampal neurons from glutamate-induced cell death through activation of Nrf2 and up-regulation of antioxidant genes
- Epigallocatechin gallate exacerbates fluoride-induced oxidative stress mediated testicular toxicity in rats through the activation of Nrf2 signaling pathway
- Actinidia callosa peel (kiwi fruit) ethanol extracts protected neural cells apoptosis induced by methylglyoxal through Nrf2 activation
- Nrf2 activation, an innovative therapeutic alternative in cerebral ischemia
- Role of growth hormone in maturation and activation of dendritic cells via miR‐200a and the Keap1/Nrf2 pathway
- Propofol pretreatment attenuates remote kidney injury induced by orthotopic liver autotransplantation, which is correlated with the activation of Nrf2 in rats
- Capsaicin Induces Heme Oxygenase-1 Expression in HepG2 Cells Via Activation of PI3K-Nrf2 Signaling: NAD(P)H:Quinone Oxidoreductase as a Potential Target
- Propofol attenuates lipopolysaccharide-induced reactive oxygen species production through activation of Nrf2/GSH and suppression of NADPH oxidase in human …
- … TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt …
- Activation of Nrf2 Pathways Correlates with Resistance of NSCLC Cell Lines to CBP501 In Vitro
- Identification of UV-protective activators of nuclear factor erythroid-derived 2-related factor 2 (Nrf2) by combining a chemical library screen with computer …
- CO/HO-1 induces NQO-1 expression via Nrf2 activation
- Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis
- Glutathione biosynthesis via activation of the nuclear factor E2–related factor 2 (Nrf2)–antioxidant-response element (ARE) pathway is essential for neuroprotective …
- Performance of the N/TERT epidermal model for skin sensitizer identification via Nrf2-Keap1-ARE pathway activation
- MicroRNA/gene profiling unveils early molecular changes and NRF2 activation in a rat model recapitulating human HCC.
- Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways
- Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2
- Homocysteine induces heme oxygenase-1 expression via transcription factor Nrf2 activation in HepG2 cells
- Protolichesterinic acid derivatives: α-methylene-γ-lactones as potent dual activators of PPARγ and Nrf2 transcriptional factors
- Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein
- Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPARγ-dependent transcription by distinct signaling pathways and with significantly different …
- … Effect of Chung-Pae, an Experimental Herbal Formula, on Acute Lung Inflammation Is Associated with Suppression of NF-κB and Activation of Nrf2
- Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in homocysteic acid-induced cytotoxicity in HT-22 cells
- Activation of the Mouse Heme Oxygenase-1 Gene by 15-Deoxy-Δ12,14-Prostaglandin J2 Is Mediated by the Stress Response Elements and Transcription Factor …
- Dual TNFα-induced effects on NRF2 mediated antioxidant defence in astrocyte-rich cultures: role of protein kinase activation
- Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus …
- [18] Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements
- Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway
- … oxyacantha L.) Bark Extract Regulates Antioxidant Response Element (ARE)‐Mediated Enzyme Expression Via Nrf2 Pathway Activation in Normal Hepatocyte Cell …
- Baicalin Ameliorates H2O2 Induced Cytotoxicity in HK-2 Cells through the Inhibition of ER Stress and the Activation of Nrf2 Signaling
- … Keratinocyte HaCaT Cells against H2O2‐Induced Oxidative Stress and Apoptosis through Upregulation of HO‐1 Expression via Activation of the PI3K/Akt/Nrf2 …
- Involvement of Nrf2 activation in the upregulation of S100A9 by exposure to inorganic arsenite
- Effects of that ATRA inhibits Nrf2-ARE pathway on glial cells activation after intracerebral hemorrhage
- Heterocyclic chalcone activators of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) with improved in vivo efficacy
- Dopaminergic neuroprotection via Nrf2-ARE pathway activation: identification of an activator from green perilla leaves
- … CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and …
- Dual pathways of p53 mediated glucolipotoxicity-induced apoptosis of rat cardiomyoblast cell: activation of p53 proapoptosis and inhibition of Nrf2-NQO1 …
- … extract of Ecklonia cava against oxidative stress are associated with upregulation of Nrf2-mediated HO-1 and NQO-1 expression through activation of the MAPK …
- Polymeric procyanidin fraction from defatted grape seeds protects HepG2 cells against oxidative stress by inducing phase II enzymes via Nrf2 activation
- … : S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: Involvement of Nrf2 transcription factor activation and modulation of …
- … of the mushroom Mycoleptodonoides aitchisonii induces a series of anti-oxidative and phase II detoxifying enzymes through activation of the transcription factor Nrf2
- Tanshinone IIA protects against triptolide-induced liver injury via Nrf2/ARE activation
- 15-Deoxy-prostaglandin J2 anti-inflammation in a rat model of chronic obstructive pulmonary disease and human bronchial epithelial cells via Nrf2 activation
- Activation of the Nrf2 pathway, but decreased γ-glutamylcysteine synthetase heavy subunit chain levels and caspase-3-dependent apoptosis during exposure of …
- Activation of the Nrf2-antioxidant system by a novel cyclooxygenase-2 inhibitor furan-2-yl-3-pyridin-2-yl-propenone: implication in anti-inflammatory function by Nrf2 …
- Traumatic brain injury induces the activation of the Nrf2-ARE pathway in the lung in rats
- Induction of NAD (P) H: quinone oxidoreductase 1 expression by cysteine via Nrf2 activation in human intestinal epithelial LS180 cells
- Nuclear factor E2-related factor-2 (Nrf2) is required for NLRP3 and AIM2 inflammasome activation
- Activation of the Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor 2 (Nrf2) pathway through covalent modification of the 2-alkenal group of aliphatic …
- 5-Aminolevulinic acid combined with sodium ferrous citrate ameliorates H2O2-induced cardiomyocyte hypertrophy via activation of the MAPK/Nrf2/HO-1 pathway
- Activation of Nrf2 restores klotho expression and attenuates oxidative stress and inflammation in CKD
- Fucoxanthin enhances HO-1 and NQO1 expression in murine hepatic BNL CL. 2 cells through activation of the Nrf2/ARE system partially by its pro-oxidant activity
- … -1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 …
- Synergistic activation of the Nrf2-signaling pathway by glyceollins under oxidative stress induced by glutathione depletion
- Ferulic acid induces heme oxygenase-1 via activation of ERK and Nrf2
- Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation
- Inhibition of NO-induced β-cell death by novel NF-κB inhibitor (−)-DHMEQ via activation of Nrf2–ARE pathway
- Chlorella ethanol extract induced phase II enzyme through NFE2L2 (nuclear factor [erythroid-derived] 2-like 2, NRF2) activation and protected ethanol-induced …
- … inhibit UVB-Induced MMP expression and promote type I procollagen production via repression of MAPK/AP-1/NF-κB and activation of AMPK/Nrf2 in HaCaT cells and …
- Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2
- Site-specific modification of the electrophile sensor protein Keap1 and activation of Nrf2-dependent gene expression
- Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin
- … -mediated neuroprotection involves estrogen receptor-dependent crosstalk between Akt and ERK1/2 pathways: a novel mechanism of Nrf2/ARE signaling activation
- Molecular mechanisms involved in enhancing HO-1 expression: de-repression by heme and activation by Nrf2, the” one-two” punch
- Attenuation of Aβ25–35-induced parallel autophagic and apoptotic cell death by gypenoside XVII through the estrogen receptor-dependent activation of Nrf2/ARE …
- Tert-Butylhydroquinone as a Phenolic Activator of Nrf2 Antagonizes Arsenic-Induced Oxidative Cytotoxicity but Promotes Arsenic Methylation and Detoxication in …
- Oxidative stress in multiple sclerosis pathology and therapeutic potential of Nrf2 activation
- Relationships between level of lipid peroxidation products and expression of Nrf2 and its activators/inhibitors in non-small cell lung cancer tissue
- Analytical approaches for quantification of a Nrf2 pathway activator: overcoming bioanalytical challenges to support a toxicity study
- Activation of nuclear factor-erythroid 2-related factor 2 (Nrf2) in the basilar artery after subarachnoid hemorrhage in rats
- Maslinic acid induces HO-1 and NOQ1 expression via activation of Nrf2 transcription factor
- … ∆ 2-pioglitazone, an analogue of pioglitazone, on colon cancer cell survival: Evidence of drug treatment association with autophagy and activation of the Nrf2 …
- … and hexane fractions from Orostachys japonicus in LPS-stimulated RAW 264.7 cells via upregulation of Nrf2 expression and activation of MAPK signaling …
- Cyclo (His‐Pro) up‐regulates heme oxygenase 1 via activation of Nrf2‐ARE signalling
- Methionine sulfoxide reductase A attenuates heme oxygenase-1 induction through inhibition of Nrf2 activation
- Lipoxin A4-Induced Heme Oxygenase-1 Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury via p38 MAPK Activation and Nrf2/ARE Complex
- Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target
- Simultaneous Activation of Nrf2 and Elevation of Antioxidant Chemicals in Management of Post-Traumatic Stress Disorders and Traumatic Brain Injury.
- Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
- Withdrawal: Hsp90 interaction with INrf2 (Keap1) mediates stress-induced Nrf2 activation.
- Apomorphine protects against 6‐hydroxydopamine‐induced neuronal cell death through activation of the Nrf2‐ARE pathway
- Sulfhydryl-reactive phytochemicals as dual activators of transcription factors NRF2 and HSF1
- Protective Effects of BML-111 on Cerulein-Induced Acute Pancreatitis-Associated Lung Injury via Activation of Nrf2/ARE Signaling Pathway
- Acute exposure to 3‐methylcholanthrene induces hepatic oxidative stress via activation of the Nrf2/ARE signaling pathway in mice
- Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in …
- Curcumin reduces paraquat-induced oxidative injury in A549 cells by activation of the Nrf2-ARE pathway
- ERK1/2 activation in quercetin-treated BEAS-2B cell plays a role in Nrf2-driven HO-1 expression
- Preconditioning with Gua Lou Gui Zhi decoction enhances H2O2‑induced Nrf2/HO‑1 activation in PC12 cells
- Activation of Nrf2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stress
- … on LPS-induced NO and PGE2 production in BV2 microglial cells via inhibition of ROS/PI3K/Akt-mediated NF-κB signaling and activation of Nrf2-dependent HO-1
- Chemoenzymatic synthesis of (2 R, 3 R, 4 R)-dehydroxymethylepoxyquinomicin (DHMEQ), a new activator of antioxidant transcription factor Nrf2
- DJ-1 mediates the delayed cardioprotection of hypoxic preconditioning through activation of Nrf2 and subsequent upregulation of antioxidative enzymes
- Antioxidant defense: Effects of an NRF2 ARE polymorphism on the activation of phase II enzymes
- Flavonoid naringin inhibits microglial activation and exerts neuroprotection against deltamethrin induced neurotoxicity through Nrf2/ARE signaling in the cortex and …
- Activation of NRF2 coordinates DDAH/PPAR-γ/ENOS pathways that enhance nitric oxide generation in human glomerular endothelial cells
- Correction: TNF mediates the sustained activation of Nrf2 in human monocytes
- Dual energy precursor and Nrf2 activator treatment additively improve redox glutathione levels and neuron survival in aging and in Alzheimer mouse neurons …
- Long-term cadmium exposure impairs activation of Nrf2-mediated defense mechanism
- The Nrf2-ARE activation protect neurones against oxidative stress
- The Nrf2 activator, tBHQ, exacerbates immediate hypersensitivity response to food allergen (HYP7P. 315)
- Nrf2 cysteine residues are critical for oxidant/electrophile-sensing, Keap1-dependent ubiquitination-proteasomal degradation, and transcription activation
- Activation of the Nrf2-ARE pathway as a therapeutic strategy in Parkinson’s disease
- … L. inhibits the lipopolysaccharide‐induced inflammatory response in RAW264. 7 macrophages through haem oxygenase‐1 induction and activation of the Nrf2 …
- P179 Celecoxib-mediated activation of an AMPK-CREB-Nrf2 dependent pathway: a novel mechanism for endothelial cytoprotection in chronic systemic inflammation
- The role of sulforaphane on duchenne muscular dystrophy by activation of Nrf2
- Nrf2 activation protects cells from HEMA-induced apoptosis
- Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on Glutathione, Keap1 and Nrf2 Activation In Vitro (P1. 204)
- Magnolia bark extract is a potent Nrf2 activator
- An Nrf2 activator, oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice
- Neuroprotective effect of Chinese herbal monomers and extracts via activation of Nrf2 signal pathway
- Inhibition of IFN production by the Nrf2 activators, tBHQ and BHA, in activated murine T cells
- Defect of Nrf2-ARE signaling activation in corneal stromal cells of keratoconus
- Heme oxygenase-1 induction through p38 MAPK/Nrf2 activation by ethanol extract of Artemisia capillaries inhibits LPS-activated iNOS, COX-2, and HMGB1 in …
- Schisandrin B protects against nephrotoxicity induced by cisplatin in HK-2 cells via Nrf2-ARE activation
- GW26-e2968 Selenium prevents from atherosclerosis formation by maintaining antioxidant activation through the Akt/GSK3β/Nrf2 axis in diabetes
- Cheogjogupye-tang has anti-oxidant potential through the activation of Nrf2
- Homocysteine induces heme oxygenase-1 expression via transcription factor Nrf2 activation in HepG2 Cells
- Activation of Nrf2 by Exercise Training and Curcumin Contributes to Sympatho-Inhibition in Heart Failure
- Activation of Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) enhances cyclooxygenase 2 expression via promoter antioxidant response element in preglomerular …
- Aged garlic extract reduces ROS production and cell death induced by 6-hydroxydopamine through activation of the Nrf2-ARE pathway in SH-SY5Y cells
- Analysis of the activation of the Nrf2-ARE pathway following optic nerve injury in mice
- Inhibition of liver fibrosis by solubilized coenzyme Q10: Role of Nrf2 activation in inhibiting transforming growth factor-β1 expression
- Activation of nuclear receptors CAR and NRF2 by garlic and garlic constituents
- Unconjugated Bilirubin mediated oxidative stress, ER stress, and activation of Nrf2 pathway
- Taxifolin Exerts Cytoprotective Effect by Activation of Nrf2-ARE Signaling Pathway in HepG2 cells
- Nrf2 pathway activation regulates radiation resistance in lung squamous cell carcinoma
- Determination of the Effects of Nrf2 upon the Early Events of Jurkat T Cell Activation by Use of CRISPR‐CAS9 Mediated Mutation
- Activation of Nrf2 by Sulforaphane via the AKT/GSK-3β/Fyn pathway prevents angiotensin ii-induced cardiomyopathy
- Mechanism of ischemic postconditioning-induced activation of Nrf2-ARE signaling pathway during myocardial ischemia-reperfusion: the relationship with ROS
- ATM Mutant Lymphoid Tumour Cells Exhibit Impaired Activation of the Redox-Sensitive Nrf2-ARE Detoxification Pathway and Are Differentially Sensitive to Nrf2 …
- The activation mechanism of Nrf2-ARE pathway in protective effect of ischemia and pinacidil postconditioning on isolated rat hearts
- 201 Regulation of INOS Function, Redox State and NRF2 Activation by Macrophage GCH1 and Tetrahydrobiopterin
- The effects of pyrrolidine dithiocarbamate on the activation of Nrf2 pathway after paraquat induced lung injury in rats
- δ-opioid receptor activation increases Nrf2 nuclear translocation and stabilizes mitochondrial membrane potential of hypoxic cells
- Project 1: The effect of Nrf2 activators on mesenchymal stem cell viability in response to light curable dimethacrylate resins and Project 2: 3D architectural influences …
- An Activator Of AMP Activated Kinase (AMPK) Restores Nrf2 Protein Levels Decreased By Chronic Cigarette Smoke Exposure
- Effects of Perilla frutescens on modulations of CYP1A1/2, HO‐1 and activation of Nrf2 in oxidative stress‐induced hepatotoxicity (647.19)
- Anti-inflammatory and antioxidant activities of Nrf2/HO-1 activators: in vitro studies in microglia and retinal cells
- Nrf2-mediated pentose phosphate pathway activity promotes macrophage inflammasome activation and bacterial killing in microbial sepsis (INM6P. 330)
- Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells …
- Identification of Chromomoric Acid CI as an Nrf2 Activator in Chromolaena odorata
- Identification of the Constituents for Nrf2 Activation and NF-κB Suppression in Dangguisoo-san
- Analysis of electrophile-induced Nrf2 gene activation
- Treatment with an Nrf2 Activator Ameliorates Acute Pancreatitis in Experimental Animals
- Exploring the Protective Effect of Nrf2 Activator On Ischemia Reperfusion Injury in Rat Liver.: Abstract# C2063
- … Arthritis Severity in Experimental Arthritis Model Via Reciprocal Regulation of Th17–Regulatory T Cells and Mediating Heme Oxygenase-1 Via NRF2 Activation
- Reporter Protein Complementation Imaging Assay to Screen and Study Nrf2 Activators in Cells and Living Animals
- Reduced ABCA1 expression and low Nrf2 activation due to
- Isolation of natural Nrf2 activators from American ginseng
- Modulation of Nrf2-activation by hepatitis B virus
- Chamomile (Matricaria chamomilla L.) upregulates heme oxygenase-1 through activation of ERK-Nrf2 signaling: Cytoprotective mechanism against oxidative damage
- Zerumbone, a sesquiterpene derived from tropical ginger, induces heme oxygenase-1 expression via activation of Nrf2 signaling in mouse epidermal cells and …
- Induction of cytochrome P450 by Nrf2 activators: Implication for aldehyde metabolism
- Natural Nrf2 activators protect cells from oxidative damage inflicted by angiotensin II or aldosterone
- PREVENTIVE AND/OR THERAPEUTIC EFFECT OF NRF2 ACTIVATORS ON DIABETES-OR ANGIOTENSIN II-INDUCED CARDIOMYOPATHY
- Inhibitory regulation of Nrf2 activation by RAC3/AIB1/SRC-3
- Nrf2 activation suppresses production of T cell cytokines and IgM in C57BL/6 mice (90.26)
- 2116 Activation of nuclear factor (erythroid 2-like)-related factor 2 (NRF2) and NRF-2 dependent genes by ischemic preconditioning and postconditioning: New …
- Angiotensin receptor blockade improves antioxidant activity by increasing nrf2 activation during a glucose challenge (693.8)
- Nrf2 Activation by Dimercaptopropanol Attenuates Mutant Huntingtin Toxicity
- Paradoxical roles of Nrf2 activation in arsenic-induced beta-cell dysfunction
- … , 10aS)-10a-ethynyl-4b, 8, 8-trimethyl-3, 7-dioxo-3, 4b, 7, 8, 8a, 9, 10, 10a-octahydro-phenanthrene-2, 6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for …
- Nrf2 activation by TUDCA in experimental models of Parkinson’s disease
- Prophylactic Nrf2 Activation Halts Progression of the Severe Adult Phenotype of Sickle Cell Disease in Transgenic Mice
- Nrf2 Activation And The Role Of NADPH Oxidase And Nrf2 In The Production Of Interferon-³ (IFN-³) By Lung Neutrophils During Pneumococcal Pneumonia In Mice
- Treatment With the Nrf2 Activator, Dimethyl Fumarate, Ameliorates Liver Ischemia/Reperfusion Injury in Rats.: Abstract# C1658
- Targeting NRF2 Activation Modulates X-Ros Signaling in Dystrophic Skeletal Muscle
- Nrf2-dependent* ARE activation in neural cells
- Inhibition Of Cigarette Smoke-Induced Chemokine Production By The NRF2 Activator Sulforaphane
- ROS production is required for follicle-stimulating hormone-induced Nrf2 activation in human epithelial ovarian cancer cells
- Dehydroglyasperin C Suppresses NF‐κB‐dependent Inflammation from Acute Lung Injury through Nrf2 Activation in mice
- Treatment with the Nrf2 activator, Dimethyl Fumarate, ameliorates acute pancreatitis in a rodent model
- Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis
- Treatment With the Nrf2 Activator, Dimethyl Fumarate, Ameliorates Calcineurin Inhibitor Nephrotoxicity in Rats.: Abstract# A55
- Colloidal carbon stimulation of Kupffer cells triggers Nrf2 activation in the isolated perfused rat liver
- The Nrf2 activator, tBHQ, inhibits the early production of IL‐2, but not CD69 induction, in primary murine splenocytes and human Jurkat T cells
- Sequential phosphorylation by protein kinase CK2 regulates NRF2 activation and degradation: Potential role In arsenic-induced skin carcinogenesis
- AAV-mediated activation of the Nrf2 pathway in the Nrf2-deficient mouse
- Propofol activation of the Nrf2 pathway is associated with
- Upregulation of endogenous antioxidant defenses by Nrf2 activation does not blunt exercise‐induced mitochondrial biogenesis in rats
- Activation of Nrf2 by dimethyl fumarate improves vascular calcification
- Inhibition of LXR alpha-Dependent Steatosis and Oxidative Injury by Liquiritigenin, a Licorice Flavonoid, as Mediated with Nrf2 Activation (Retracted article. See vol …
- Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe
- The role of aberrant Nrf2/Keap1 pathway activation across a broad spectrum of human cancers.
- Activation of Nrf2 skews CD4+ cells toward Th2 differentiation (152.15)
- Oral Administration of Compound K Enhances Cognitive Ability of Scopolamine-induced Memory Impaired Mice through Nrf2 Activation
- Reduced ABCA1 expression and low Nrf2 activation due to decreased lectin-like oxidized LDL receptor 1 (LOX-1) in the placenta are involved in preeclampsia
- Non-Canonical Activation of Nrf2 by Dimercaptopropaenol as a Treatment for Huntington’s Disease
- Effects of Monascin on Anti-inflammation Mediated by Nrf2 Activation in Advanced Glycation End Product-Treated THP-1 Monocytes and Methylglyoxal-Treated Wistar …
- Multiple sensing mechanism of the Keap1-Nrf2 system for responding to a wide range of activators
- Epigenetic activation of miR-200a targets the Nrf2-dependent chemoprevention pathway in breast cancer
- DIFFERENTIAL EFFECTS OF THE OXIDIZED METABOLITES OF OLTIPRAZ ON THE ACTIVATION OF C/EBPβ AND NRF2 FOR GSTA2 GENE INDUCTION
- Activation Of Nrf2 Attenuates Hypoxia-Induced Cardiopulmonary Alterations In Mice
- Impaired activation of Nrf2-ARE signaling pathway: a possible mechanism for Keratoconus
- Activation of the NRF2-mediated phase 2 enzyme response as a prophylactic strategy for treatment of stroke and neurodegeneration
- RETRACTED: Inhibition of LXRα-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation.
- Activation of Nrf2 Is Responsible for the Overexpression of Peroxiredoxin and Sulphiredoxin in Smoking Induced Human Lung Cancer.
- Biological and Chemical Analysis of Small Molecule Activators of Anti-Inflammatory and Antioxidant Nrf2-Keap1 Signaling
- Nrf2 deficiency promotes microgila/macrophage activation after subarachno id hemorrhage in mice
- The Synthesis of Tetrahydroquinazolone Derivatives for the Activation of Transcription Factor Nrf2 as Chemoprevention Agents
- Lipid oxidation and nitration products as activators of cytoprotective Nrf2 signaling in the endothelium
- Activation and Nuclear Translocation of the Transcription Factor Nrf2 by the MAP Kinase Family
- Activation of Nrf2 caused by tert-butylbenzoquinone, a metabolite of butylated hydroxyanisole, requires electrophilic modification of Keap1 through its reactive thiols
- PAR-2 activation enhances Nrf2 signaling in keratinocytes
- Nrf2 transcription factor activation modulates endothelial inflammatory response triggered by TNF-alpha
- A62 LUNG FIBROSIS: FIBROBLAST BIOLOGY: Small-Molecule And Peptide Activators Of The Nrf2-Dependent Antioxidant Response Element
- Persistent Activation of Nrf2 through p62 in Auditory Cells
- Delta-Aminolevulinate Preferentially Induces Gamma-Globin Expression in Erythroid Cells through Activation of NRF2 Stress Response
- B34 LUNG MACROPHAGE ACTIVATION IN HEALTH AND DISEASE: Nrf2 And Pu. 1 Are Coordinately Regulated In The Alveolar Macrophage
- NRF2 pathway activation and adjuvant chemotherapy benefit in lung squamous cell carcinoma David W. Cescon, Desmond She, 2 Shingo Sakashita, 2, 5 …
- Cigarette Smoke Triggers Excessive Complement Activation in Human RPE Cells: Involvement of Nrf2 signaling
- Carbocisteine Reduced Influenza Virus-Induced Pulmonary Inflammation Via Activation Of Nrf2 In Cigarette Smoke-Exposed Mice
- Low concentration of 4-hydroxy hexenal increases heme oxygenase-1 expression through activation of Nrf2 and antioxidative activity in vascular endothelial …
- Abstract A58: Cul3‐mediated Nrf2 ubiquitination and ARE activation are dependent on the partial molar volume at position 151 of Keap1
- Methionine sulfoxide reductase A attenuates heme oxygenase-1 induction through inhibition of Nrf2 activation (P1377)
- Activation Of The NRF2/ARE Pathway Protects Against Oxidative Stress And Alveolar Epithelial Barrier Dysfunction In HIV-1 Transgenic Rats
- Phosphorylation Of Nrf2 By Casein Kinase 2 (CK2) Regulates Activation And Degradation
- Liver Specific Knockout Atg5 Causes Persistent Activation of Nrf2 and Protects Against Acetaminophen‐Induced Liver Injury
- Activation of Nrf2 Is Required for Up-Regulation of the π Class of Glutathione S-Transferase in Rat Primary Hepatocytes with l-Methionine Starvation
- Bruton’s Tyrosine Kinase and Nrf2 mediate TLR-induced activation of Heme oxygenase-1 gene expression in macrophages (116.16)
- ISCHAEMIC PRECONDITIONING PROTECTS SKELETAL MUSCLE MYOTUBES AGAINST ISCHAEMIA-REPERFUSION INJURY THROUGH ACTIVATION OF NRF2 …
- Genetic Ablation of Nrf2 Enhances Susceptibility to Double-Stranded RNA-or Cigarette Smoke-Induced Activation of NF-κB and IRF-3 in Macrophages.
- Activation of NRF2/ABCC1 axis confers resistance to topoisomerase II poisons in human oral malignancies
- Resveratrol inhibits oxidative stress and prevents estrogen-induced breast carcinogenesis via activation of NRF2-mediated protective pathways.
- Molecular Effects of Baicalein in Hct116 Cells and Caenorhabditis elegans: Activation of the Nrf2 Signaling Pathway and Prolongation of Lifespan
- Chlorella Ethanol Extract Induced Phase II Enzyme Through NFE2L2 (Nuclear Factor [Erythroid-Derived] 2-Like 2, NRF2) Activation and Protected Ethanol-Induced …
- Nrf2 Inhibits NF-κB Activation During Ischemia Reperfusion Injury and Suppresses Subsequent Development of Cardiac Allograft Vasculopathy in Murine Heart …
- Activation of NRF2/ARE Pathway Regulates Hydrogen Peroxide Releasing NADPH Oxidase NOX4 in Endothelial Cells
- Neutrophil elastase suppresses cigarette smoke extract‐induced activation of anti‐oxidative pathway by mediating nrf2 degradation in bronchial epithelial cells …
- Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt
- miR‐125b transcriptionally induced by Nrf2 inhibits AhR repressor for AhR activation (663.12)
- NRF2 PROTECTS AGAINST ISCHEMIA REPERFUSION INJURY VIA INHIBITION OF NF-κB ACTIVATION AND SUPPRESSES SUBSEQUENT DEVELOPMENT OF …
- Correction: Activation of Transcription Factor Nrf2 Signalling by the Sphingosine Kinase Inhibitor SKI-II Is Mediated by the Formation of Keap1 Dimers
- Juices of cherry and strawberry confer protection of human bronchial epithelial cells against arsenic-induced toxicity via activation of Nrf2 signaling pathway.
- Ethanolic extract of Sargassium serratifolium attenuates inflammatory responses by regulating Nrf2 and NF-B activation in lipopolysaccharide-stimulated RAW 264.7 …
- The Oxidant Response Transcription Factor NRF2 Mediates Heme Activation of Placenta Growth Factor Expression in Erythroid Cells, a Contributor to …
- PAR-2 activation enhances Nrf2 signaling in keratinocytes: Is it associated with the pathogenesis of vitiligo?
- A small-molecule activator of Hsf1, Nrf1, and Nrf2 mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy models (S34. 006)
- Amyloid-Beta Induced Neurotoxicity Is Attenuated by Partridge Berry Polyphenols through Bcl-2/Bcl-XL and Keap1-Nrf2 Activation
- Research Article Cordyceps sinensis Increases Hypoxia Tolerance by Inducing Heme Oxygenase-1 and Metallothionein via Nrf2 Activation in Human Lung …
- Auranofin, a gold (1)-containing antirheumatic compound, activates Keap1/Nrf2 signaling via Rac1/iNOS signal and mitogen-activated protein kinase activation
- Pharmacologic and transgenic activation of nuclear factor-erythroid 2-related factor 2 (Nrf2) alters kinetics and toxicodynamics of xenobiotics
- Free Paper Presentation: OS-64; Macroautophagy Activation via Nrf2-Dependent Up-Regulation of LC3B Limits Proteasome Inhibitor (PI)-Induced Lung Cancer Cell …
- Sulforaphane suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse epidermal JB6 P+ cell transformation through epigenetic re-activation of Nrf2.
- 5.1 Nrf2 transcriptional activity controls Nlrp3 inflammasome activation independent of reactive oxygen species levels
- D33 AIRWAY EPITHELIA ACTIVATION AND RESPONSES TO TREATMENT: Nuclear Factor, Erythroid Derived 2, Like 2 (nrf2) Regulates Airway Epithelial Barrier …
- Sulfuraphane (SFN) activation of nuclear factor E2‐related factor 2 (Nrf2) increases expression and transport activity of P‐glycoprotein (P‐gp) and breast cancer …
- … Korean Academy of Tuberculosis and Respiratory Diseases: Slide Session; OS-064: Lung Cancer; Macroautophagy Activation via Nrf2-Dependent Up-Regulation of …
- Heme Oxygenase-1 via Transcriptional Activation of Nrf2 Attenuates Apoptosis in Lung Cancer Cells
- Canonical and non-canonical mechanisms of Nrf2 activation
- NRF2 activation in cancer: from DNA to protein
- Activators and inhibitors of NRF2: a review of their potential for clinical development
- Naturally occurring Nrf2 activators: potential in treatment of liver injury
- Role of Nrf2 and its activators in respiratory diseases
- Nrf2 activator for the treatment of kidney diseases
- NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis
- Preventive and protective roles of dietary Nrf2 activators against central nervous system diseases
- Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function
- Repurposing the NRF2 activator dimethyl fumarate as therapy against synucleinopathy in Parkinson’s disease
- Sulforaphane and other nutrigenomic Nrf2 activators: can the clinician’s expectation be matched by the reality?
- Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction
- Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury
- Nrf2 activation promotes lung cancer metastasis by inhibiting the degradation of Bach1
- Therapeutic effects of Nrf2 activation by bardoxolone methyl in chronic heart failure
- Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1: Nrf2 interface
- Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic …
- Nrf2 activation is a potential therapeutic approach to attenuate diabetic retinopathy
- Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
- Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson’s disease
- Control of oxidative stress and inflammation in sickle cell disease with the Nrf2 activator dimethyl fumarate
- Hydrogen sulfide induces Keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation
- Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates
- Nrf2 activators as potential modulators of injury in human kidney cells
- Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation
- Identification of non-electrophilic Nrf2 activators from approved drugs
- C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape
- Nrf2 mutagenic activation drives hepatocarcinogenesis
- ROS-independent Nrf2 activation in prostate cancer
- The role of Nrf2 in NLRP3 inflammasome activation
- A dual AMPK/Nrf2 activator reduces brain inflammation after stroke by enhancing microglia M2 polarization
- Recent advances of natural polyphenols activators for Keap1‐Nrf2 signaling pathway
- The effect of dietary supplementation with curcumin on redox status and Nrf2 activation in patients with nondiabetic or diabetic proteinuric chronic kidney disease: a …
- Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death
- Differential effects of the Nrf2 activators tBHQ and CDDO-Im on the early events of T cell activation
- Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation
- NRF2 activation impairs quiescence and bone marrow reconstitution capacity of hematopoietic stem cells
- Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis
- Lutein prevents osteoarthritis through Nrf2 activation and downregulation of inflammation
- … /nanoparticulate powders of a novel Nrf2 activator and an aerosol performance enhancer for pulmonary delivery targeting the lung Nrf2/Keap-1 pathway
- Nrf2 activation provides atheroprotection in diabetic mice through concerted upregulation of antioxidant, anti-inflammatory, and autophagy mechanisms
- High CD44 expression mediates p62-associated NFE2L2/NRF2 activation in breast cancer stem cell-like cells: Implications for cancer stem cell resistance
- The Nrf2 activator tBHQ inhibits the activation of primary murine natural killer cells
- Pro-fibrotic compounds induce stellate cell activation, ECM-remodelling and Nrf2 activation in a human 3D-multicellular model of liver fibrosis
- Nrf2‐lncRNA controls cell fate by modulating p53‐dependent Nrf2 activation as an miRNA sponge for Plk2 and p21cip1
- Anti-neuroinflammatory effect of emodin in LPS-stimulated microglia: involvement of AMPK/Nrf2 activation
- Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish
- Systemic activation of NRF2 alleviates lethal autoimmune inflammation in scurfy mice
- Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis
- Nrf2 activation in osteoblasts suppresses osteoclastogenesis via inhibiting IL-6 expression.
- Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival
- Broccoli sprout extract prevents diabetic cardiomyopathy via Nrf2 activation in db/db T2DM mice
- Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding
- Elevating CXCR7 improves angiogenic function of EPCs via Akt/GSK-3β/Fyn-mediated Nrf2 activation in diabetic limb ischemia
- Oxidative damage control in a human (mini-) organ: Nrf2 activation protects against oxidative stress-induced hair growth inhibition
- Astaxanthin suppresses cigarette smoke-induced emphysema through Nrf2 activation in mice
- Liver injury attenuation by curcumin in a rat NASH model: an Nrf2 activation-mediated effect?
- Lutein suppresses oxidative stress and inflammation by Nrf2 activation in an osteoporosis rat model
- Tanshinone IIA attenuates contrast-induced nephropathy via Nrf2 activation in rats
- Methane ameliorates spinal cord ischemia-reperfusion injury in rats: antioxidant, anti-inflammatory and anti-apoptotic activity mediated by Nrf2 activation
- … underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down …
- Non-covalent NRF2 activation confers greater cellular protection than covalent activation
- Are astrocytes the predominant cell type for activation of Nrf2 in aging and neurodegeneration?
- ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells
- Nrf2 activator RTA-408 protects against ozone-induced acute asthma exacerbation by suppressing ROS and γδT17 cells
- … -induced adhesion molecule expression and oxidant production in human aortic endothelial cells by p38-mediated Nrf2 activation and antioxidant enzyme …
- Diverse Nrf2 activators coordinated to cobalt carbonyls induce heme oxygenase-1 and release carbon monoxide in vitro and in vivo
- Nrf2 activation protects mouse beta cells from glucolipotoxicity by restoring mitochondrial function and physiological redox balance
- Chemical activation of the constitutive androstane receptor leads to activation of oxidant-induced Nrf2
- Non-canonical activation of NRF2: New insights and its relevance to disease
- Collaborative Power of Nrf2 and PPARγ Activators against Metabolic and Drug-Induced Oxidative Injury
- Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
- Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
- Lycopene relieves AFB1-induced liver injury through enhancing hepatic antioxidation and detoxification potential with Nrf2 activation
- Carnosol as a Nrf2 activator improves endothelial barrier function through antioxidative mechanisms
- Cytoprotective effects of a novel Nrf2 activator, RS9, in rhodopsin Pro347Leu rabbits
- A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation
- Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats
- Nrf2 activator RS9 suppresses pathological ocular angiogenesis and hyperpermeability
- Chronic oxidative stress, mitochondrial dysfunction, Nrf2 activation and inflammation in the hippocampus accompany heightened systemic inflammation and …
- Antioxidant and pro-angiogenic effects of corilagin in rat cerebral ischemia via Nrf2 activation
- An overview of the advantages of KEAP1-NRF2 system activation during inflammatory disease treatment
- Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice
- Targeted Nrf2 activation therapy with RTA 408 enhances regenerative capacity of diabetic wounds
- Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation
- HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice
- A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase
- The NRF2 activator DH404 attenuates adverse ventricular remodeling post-myocardial infarction by modifying redox signalling
- Rosmarinic acid attenuates β-amyloid-induced oxidative stress via Akt/GSK-3β/Fyn-mediated Nrf2 activation in PC12 cells
- Fucoxanthin elicits epigenetic modifications, Nrf2 activation and blocking transformation in mouse skin JB6 P+ cells
- Inhibiting inflammation and modulating oxidative stress in oxalate-induced nephrolithiasis with the Nrf2 activator dimethyl fumarate
- Valproic acid sensitizes hepatocellular carcinoma cells to proton therapy by suppressing NRF2 activation
- Isoalantolactone protects LPS-induced acute lung injury through Nrf2 activation
- Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury
- Artesunate protects LPS-induced acute lung injury by inhibiting TLR4 expression and inducing Nrf2 activation
- Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity
- A solid dispersion of quercetin shows enhanced Nrf2 activation and protective effects against oxidative injury in a mouse model of dry age-related macular …
- Zedoarondiol attenuates endothelial cells injury induced by oxidized low-density lipoprotein via Nrf2 activation
- Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury
- Antioxidant, anti-inflammatory, and neuroprotective effects of novel vinyl sulfonate compounds as nrf2 activator
- Nrf2 activation attenuates the early suppression of mitochondrial respiration due to the α-synuclein overexpression
- Nrf2 activation protects against intratracheal LPS induced mouse/murine acute respiratory distress syndrome by regulating macrophage polarization
- Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation
- Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model
- Identification of novel Nrf2 activators from Cinnamomum chartophyllum HW Li and their potential application of preventing oxidative insults in human lung …
- Oregano essential oil induces SOD1 and GSH expression through Nrf2 activation and alleviates hydrogen peroxide-induced oxidative damage in IPEC-J2 …
- Nrf2 activation by 5-lipoxygenase metabolites in human umbilical vascular endothelial cells
- A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy
- HYCO-3, a dual CO-releaser/Nrf2 activator, reduces tissue inflammation in mice challenged with lipopolysaccharide
- Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis
- Xanthohumol analogues as potent Nrf2 activators against oxidative stress mediated damages of PC12 cells
- Nrf2 activation induced by Sirt1 ameliorates acute lung injury after intestinal ischemia/reperfusion through NOX4-mediated gene regulation
- Experimental nonalcoholic steatohepatitis and liver fibrosis are ameliorated by pharmacologic activation of Nrf2 (NF-E2 p45-related factor 2)
- Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin
- Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia–reperfusion injury
- Activation of the Nrf2 cell defense pathway by ancient foods: disease prevention by important molecules and microbes lost from the modern western diet
- Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling
- Influence of Nrf2 activators on subcellular skeletal muscle protein and DNA synthesis rates after 6 weeks of milk protein feeding in older adults
- Activation of Nrf2/HO-1 pathway by nardochinoid C inhibits inflammation and oxidative stress in lipopolysaccharide-stimulated macrophages
- … persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation
- Nrf2 activation as a key event triggered by skin sensitisers: The development of the stable KeratinoSens reporter gene assay
- … inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation
- Grape seed procyanidin extract ameliorates lead-induced liver injury via miRNA153 and AKT/GSK-3β/Fyn-mediated Nrf2 activation
- Skin redox balance maintenance: the need for an Nrf2-activator delivery system
- Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells
- Xiaochaihutang attenuates liver fibrosis by activation of Nrf2 pathway in rats
- Maggot extracts alleviate inflammation and oxidative stress in acute experimental colitis via the activation of Nrf2
- A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure
- Structure-activity and structure-property relationships of novel Nrf2 activators with a 1, 2, 4-oxadiazole core and their therapeutic effects on acetaminophen (APAP) …
- Lipoic acid prevents high-fat diet-induced hepatic steatosis in Goto Kakizaki rats by reducing oxidative stress through Nrf2 activation
- A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy
- Ketone body 3‐hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina
- Antioxidant and hepatoprotective effect of polyphenols from apple pomace extract via apoptosis inhibition and Nrf2 activation in mice
- Activation of Nrf2 might reduce oxidative stress in human granulosa cells
- Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion
- Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway
- l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway
- Prodigiosin promotes Nrf2 activation to inhibit oxidative stress induced by microcystin-LR in HepG2 cells
- Schisantherin A attenuates neuroinflammation in activated microglia: role of Nrf2 activation through ERK phosphorylation
- Neuroprotective effect of Nrf2 activator dimethyl fumarate, on the hippocampal neurons in chemical kindling model in rat
- Nrf2 activation by SK-119 attenuates oxidative stress, UVB, and LPS-induced damage
- RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE–dependent repression
- Flazin as a promising Nrf2 pathway activator
- Protective activity of tovophyllin A, a xanthone isolated from Garcinia mangostana pericarps, against acetaminophen-induced liver damage: role of Nrf2 activation
- … rat offspring against hypertension programmed by prenatal dexamethasone administration and postnatal high-fat diet with the Nrf2 activator dimethyl fumarate during …
- Sulforaphane protects from myocardial ischemia-reperfusion damage through the balanced activation of Nrf2/AhR
- Mesenchymal stromal cell-derived extracellular vesicles protect against acute kidney injury through anti-oxidation by enhancing Nrf2/ARE activation in rats
- … Isolated from Pogostemon cablin Bentham Exerts Antioxidant and Cytoprotective Effects in HepG2 Cells: Possible Role of ERK-Dependent Nrf2 Activation
- Honokiol alleviates oxidative stress-induced neurotoxicity via activation of Nrf2
- Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway
- Nrf2 activator, sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signaling and rectification of oxidant-antioxidant imbalance in …
- Short-term pharmacological activation of Nrf2 ameliorates vascular dysfunction in aged rats and in pathological human vasculature. A potential target for …
- Activation of Nrf2-antioxidant signaling by 1, 25-dihydroxycholecalciferol prevents leptin-induced oxidative stress and inflammation in human endothelial cells
- 1, 25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling
- NRF2 activation inhibits both TGF-β1-and IL-13-mediated periostin expression in fibroblasts: Benefit of cinnamaldehyde for antifibrotic treatment
- Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway
- Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation
- Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium
- Simultaneous activation of Nrf2 and elevation of antioxidant compounds for reducing oxidative stress and chronic inflammation in human Alzheimer’s disease
- Copper diethyldithiocarbamate as an activator of Nrf2 in cultured vascular endothelial cells
- Reversal of cigarette smoke extract‐induced sinonasal epithelial cell barrier dysfunction through Nrf2 Activation
- Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes
- The hepatoprotective effects of Sedum sarmentosum extract and its isolated major constituent through Nrf2 activation and NF-κB inhibition
- Rice protein suppresses ROS generation and stimulates antioxidant gene expression via Nrf2 activation in adult rats
- PFOS induces adipogenesis and glucose uptake in association with activation of Nrf2 signaling pathway
- The protective effects of isoliquiritigenin and glycyrrhetinic acid against triptolide-induced oxidative stress in HepG2 cells involve Nrf2 activation
- Evidence of activation of the Nrf2 pathway in multiple sclerosis patients treated with delayed-release dimethyl fumarate in the Phase 3 DEFINE and CONFIRM studies
- Astragalus membranaceus Extract Attenuates Inflammation and Oxidative Stress in Intestinal Epithelial Cells via NF-κB Activation and Nrf2 Response
- Can co-activation of Nrf2 and neurotrophic signaling pathway slow Alzheimer’s disease?
- … sativus) intake provides nutritional preconditioning against myocardial ischemia–reperfusion injury in Wild Type and ApoE (−/−) mice: Involvement of Nrf2 activation
- Nrf2 protects stellate cells from Smad-dependent cell activation
- Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons
- Diabetic wound healing and activation of Nrf2 by herbal medicine
- Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor
- Antioxidant and antihypertensive responses to oral nitrite involves activation of the Nrf2 pathway
- … -induced oxidative stress and inflammation in human umbilical vein endothelial cells through suppression of mitochondrial dysfunction and activation of Nrf2
- … , a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation
- Farrerol ameliorates APAP-induced hepatotoxicity via activation of Nrf2 and autophagy
- Evaluation of the rotenone-induced activation of the Nrf2 pathway in a neuronal model derived from human induced pluripotent stem cells
- Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in …
- Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer
- Activation of Nrf2 by costunolide provides neuroprotective effect in PC12 cells
- NRF2 through RPS6 Activation Is Related to Anti-HER2 Drug Resistance in HER2-Amplified Gastric Cancer
- Nrf2 activation is required for ligustrazine to inhibit hepatic steatosis in alcohol-preferring mice and hepatocytes
- Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation
- Dihydromyricetin relieves rheumatoid arthritis symptoms and suppresses expression of pro-inflammatory cytokines via the activation of Nrf2 pathway in rheumatoid …
- Activation of Nrf2 pathway contributes to neuroprotection by the dietary flavonoid tiliroside
- Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1/Nrf2 pathway
- The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction
- Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice
- Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults
- Comprehensive landscape of Nrf2 and p53 pathway activation dynamics by oxidative stress and DNA damage
- Niga-ichigoside F1 ameliorates high-fat diet-induced hepatic steatosis in male mice by Nrf2 activation
- Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet
- GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway
- Activation of Nrf2/HO-1 pathway and human atherosclerotic plaque vulnerability: an in vitro and in vivo study
- Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage
- Activation of Nrf2 by Ginsenoside Rh3 protects retinal pigment epithelium cells and retinal ganglion cells from UV
- Oxidative stress in metabolic disorders and drug-induced injury: the potential role of Nrf2 and PPARs activators
- Osteocalcin improves nonalcoholic fatty liver disease in mice through activation of Nrf2 and inhibition of JNK
- Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway
- Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway
- Protective effects of sulforaphane on diabetic retinopathy: activation of the Nrf2 pathway and inhibition of NLRP3 inflammasome formation
- Lactucopicrin ameliorates oxidative stress mediated by scopolamine-induced neurotoxicity through activation of the NRF2 pathway
- Primary cilium-autophagy-Nrf2 (PAN) axis activation commits human embryonic stem cells to a neuroectoderm fate
- RS 9, a novel Nrf2 activator, attenuates light‐induced death of cells of photoreceptor cells and Müller glia cells
- Sesamin enhances Nrf2-mediated protective defense against oxidative stress and inflammation in colitis via AKT and ERK activation
- Effects of acute hypoxia exposure with different durations on activation of Nrf2-ARE pathway in mouse skeletal muscle
- Activation of the KEAP1‑NRF2‑ARE signaling pathway reduces oxidative stress in Hep2 cells
- Molecular similarity guided optimization of novel Nrf2 activators with 1, 2, 4-oxadiazole core
- Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2
- Sirtuin 6 protects the brain from cerebral ischemia/reperfusion injury through NRF2 activation
- Activation of KGFR-Akt-mTOR-Nrf2 signaling protects human retinal pigment epithelium cells from Ultra-violet
- Activation of Nrf2 signaling augments vesicular stomatitis virus oncolysis via autophagy-driven suppression of antiviral immunity
- Impact of glucoraphanin-mediated activation of Nrf2 on non-alcoholic fatty liver disease with a focus on mitochondrial dysfunction
- Dietary luteolin protects against HgCl2-induced renal injury via activation of Nrf2-mediated signaling in rat
- Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy
- Compound analysis of jing liqueur and Nrf2 activation by jing liqueur—One of the most popular beverages in China
- Phenethyl isothiocyanate, a dual activator of transcription factors NRF2 and HSF1
- Activation of the Nrf2-ARE pathway by the Alternaria alternata mycotoxins altertoxin I and II
- Reversing ROS‐mediated neurotoxicity by chlorogenic acid involves its direct antioxidant activity and activation of Nrf2‐ARE signaling pathway
- Babao Dan attenuates acute ethanol-induced liver injury via Nrf2 activation and autophagy
- Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation
- Activation of NRF2/ARE by isosilybin alleviates Aβ25-35-induced oxidative stress injury in HT-22 cells
- 6-O-Galloylpaeoniflorin attenuates cerebral ischemia reperfusion-induced neuroinflammation and oxidative stress via PI3K/Akt/Nrf2 activation
- Baicalein protects human vitiligo melanocytes from oxidative stress through activation of NF-E2-related factor2 (Nrf2) signaling pathway
- A novel role of topical iodine in skin: Activation of the Nrf2 pathway
- … brain injury after experimental intracerebral hemorrhage via suppressing ROS-and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 …
- Lycopene ameliorates oxidative stress in the aging chicken ovary via activation of Nrf2/HO-1 pathway
- Cardioprotective role of azafrin in against myocardial injury in rats via activation of the Nrf2-ARE pathway
- Curcumin attenuates lipopolysaccharide/d-galactosamine-induced acute liver injury by activating Nrf2 nuclear translocation and inhibiting NF-kB activation
- Activation of AKT pathway by Nrf2/PDGFA feedback loop contributes to HCC progression
- A novel Nrf2 activator from microbial transformation inhibits radiation-induced dermatitis in mice
- Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and …
- Leonurine ameliorates D-galactose-induced aging in mice through activation of the Nrf2 signalling pathway
- KEAP1 editing using CRISPR/Cas9 for therapeutic NRF2 activation in primary human T lymphocytes
- Neuroprotective role of fucoxanthin against cerebral ischemic/reperfusion injury through activation of Nrf2/HO-1 signaling
- Ethanol-mediated stress promotes autophagic survival and aggressiveness of colon cancer cells via activation of Nrf2/HO-1 pathway
- Isoorientin ameliorates APAP-induced hepatotoxicity via activation Nrf2 antioxidative pathway: The involvement of AMPK/Akt/GSK3β
- Activation of Nrf2 signaling by sitagliptin and quercetin combination against β‐amyloid induced Alzheimer’s disease in rats
- … effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense …
- Tussilagonone-induced Nrf2 pathway activation protects HepG2 cells from oxidative injury
- KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo
- Sodium butyrate attenuates diabetes-induced aortic endothelial dysfunction via P300-mediated transcriptional activation of Nrf2
- Protection against HEMA-Induced Mitochondrial Injury In Vitro by Nrf2 Activation
- Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells
- Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation
- … mitochondrial dysfunction and oxidative stress in chicken (Gallus gallus) kidney via mitochondrial UPR inhibition and Nrf2-mediated antioxidant defense activation
- Optimization of vinyl sulfone derivatives as potent nuclear factor erythroid 2-related factor 2 (Nrf2) activators for Parkinson’s disease therapy
- Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis
- Naringenin reduces oxidative stress and improves mitochondrial dysfunction via activation of the Nrf2/ARE signaling pathway in neurons
- The natural flavone acacetin confers cardiomyocyte protection against hypoxia/reoxygenation injury via AMPK-mediated activation of Nrf2 signaling pathway
- Fluid shear stress stimulates MATE2-K expression via Nrf2 pathway activation
- Activation of KEAP1/NRF2/P62 signaling alleviates high phosphate-induced calcification of vascular smooth muscle cells by suppressing reactive oxygen …
- Air pollutant–mediated disruption of sinonasal epithelial cell barrier function is reversed by activation of the Nrf2 pathway
- Paeonol ameliorates diabetic renal fibrosis through promoting the activation of the Nrf2/ARE pathway via up-regulating Sirt1
- Cell-specific activation of the Nrf2 antioxidant pathway increases mucosal inflammation in acute but not in chronic colitis
- Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells
- L-F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF-κB inhibition and Nrf2 pathway activation
- … antiphotoaging and dermatoprotective properties in ultraviolet A-irradiated human skin fibroblast cells via the activation of Nrf2/ARE defensive pathway
- Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway
- ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress
- The Nrf2 activator vinylsulfone reduces high glucose-induced neural tube defects by suppressing cellular stress and apoptosis
- A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice
- Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway
- Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification …
- … ameliorates lipopolysaccharide-induced acute lung injury in mice by suppressing oxidative stress and inflammation via the activation of the Nrf2-mediated HO-1 …
- Activation of Nrf2/ARE pathway alleviates the cognitive deficits in PS1V97L‐Tg mouse model of Alzheimer’s disease through modulation of oxidative stress
- Luteolin ameliorates dextran sulfate sodium-induced colitis in mice possibly through activation of the Nrf2 signaling pathway
- Mechanism of isoniazid-induced hepatotoxicity in zebrafish larvae: activation of ROS-mediated ERS, apoptosis and the Nrf2 pathway
- Pharmacological activation of the Nrf2 pathway by 3H-1, 2-dithiole-3-thione is neuroprotective in a mouse model of Alzheimer disease
- HIV-Tat induces the Nrf2/ARE pathway through NMDA receptor-elicited spermine oxidase activation in human neuroblastoma cells
- Single-cell RNA-sequencing of herpes simplex virus 1-infected cells connects NRF2 activation to an antiviral program
- A novel compound AB-38b improves diabetes-associated cognitive decline in mice via activation of Nrf2/ARE pathway
- Hydrogen sulfide ameliorates learning memory impairment in APP/PS1 transgenic mice: a novel mechanism mediated by the activation of Nrf2
- Activation of GSK3β/β-TrCP axis via PHLPP1 exacerbates Nrf2 degradation leading to impairment in cell survival pathway during diabetic nephropathy
- Inhibition of PRMT5 attenuates oxidative stress-induced pyroptosis via activation of the Nrf2/HO-1 signal pathway in a mouse model of renal ischemia …
- Nrf2 activation and down-regulation of HMGB1 and MyD88 expression by amnion membrane extracts in response to the hypoxia-induced injury in cardiac …
- Activation of the NRF2-ARE signalling pathway by the Lentinula edodes polysaccharose LNT alleviates ROS-mediated cisplatin nephrotoxicity
- Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors
- SIRT6 protects vascular endothelial cells from angiotensin II-induced apoptosis and oxidative stress by promoting the activation of Nrf2/ARE signaling
- A ROS-mediated mitochondrial pathway and Nrf2 pathway activation are involved in BDE-47 induced apoptosis in Neuro-2a cells
- Bisdemethoxycurcumin protection of cardiomyocyte mainly depends on Nrf2/HO-1 activation mediated by the PI3K/AKT pathway
- Sulforaphane prevents testicular damage in Kunming mice exposed to cadmium via activation of Nrf2/ARE signaling pathways
- Activation of Nrf2 is required for normal and ChREBPα-augmented glucose-stimulated β-cell proliferation
- Nrf2 activation as a protective feedback to limit cell death in high glucose‐exposed cardiomyocytes
- Yellow Wine Polyphenolic Compounds prevents Doxorubicin‐induced cardiotoxicity through activation of the Nrf2 signalling pathway
- … endothelial cells against oxygen-glucose deprivation/reperfusion-induced barrier dysfunction via activation of PI3K/Akt/Nrf2 antioxidant signaling pathway
- … A protects lipopolysaccharide/D-galactosamine-induced acute liver injury in mice by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation
- Activation of c-Met in cancer cells mediates growth-promoting signals against oxidative stress through Nrf2-HO-1
- Activation of cannabinoid receptor type II by AM1241 ameliorates myocardial fibrosis via Nrf2-mediated inhibition of TGF-β1/Smad3 pathway in myocardial …
- NRF2/HO-1 activation via ERK pathway involved in the anti-neuroinflammatory effect of Astragaloside IV in LPS induced microglial cells
- Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway
- Ginsenoside Rb1 attenuates intestinal ischemia/reperfusion‑induced inflammation and oxidative stress via activation of the PI3K/Akt/Nrf2 signaling pathway
- Hydrogen sulfide attenuates calcification of vascular smooth muscle cells via KEAP1/NRF2/NQO1 activation
- Antioxidant properties of 5-hydroxy-4-phenyl-butenolide via activation of Nrf2/ARE signaling pathway
- A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system
- … functions of a cytoprotective effect and apoptosis induction by bioavailable marine carotenoid fucoxanthinol through modulation of the Nrf2 activation in RAW264. 7 …
- Deletion of Nrf2 leads to hepatic insulin resistance via the activation of NF-κB in mice fed a high-fat diet
- Melatonin alleviates aluminium chloride-induced immunotoxicity by inhibiting oxidative stress and apoptosis associated with the activation of Nrf2 signaling pathway
- Curcumin attenuates heat-stress-induced oxidant damage by simultaneous activation of GSH-related antioxidant enzymes and Nrf2-mediated phase II …
- Cardiac Aging–Benefits of Exercise, Nrf2 Activation and Antioxidant Signaling
- Activation of the Nrf2 signaling pathway and neuroprotection of nigral dopaminergic neurons by a novel synthetic compound KMS99220
- … induces Sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response
- Forsythiaside A exhibits anti-inflammatory effects in LPS-stimulated BV2 microglia cells through activation of Nrf2/HO-1 signaling pathway
- Construction of a novel quinoxaline as a new class of Nrf2 activator
- Applying an electrophilicity-based strategy to develop a novel nrf2 activator inspired from dietary [6]-shogaol
- Activation of Nrf2 attenuates pulmonary vascular remodeling via inhibiting endothelial-to-mesenchymal transition: an insight from a plant polyphenol
- Characterization of the potent, selective Nrf2 activator, 3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2h-chromen-2-one, in cellular and in vivo models of pulmonary …
- Ferulic acid (FA) abrogates γ-radiation induced oxidative stress and DNA damage by up-regulating nuclear translocation of Nrf2 and activation of NHEJ pathway
- Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling
- Colon-Targeted delivery facilitates the therapeutic switching of sofalcone, a gastroprotective agent, to an anticolitic drug via Nrf2 activation
- 5-(3, 4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1, 2, 4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute …
- Therapeutic potential of Salviae miltiorrhizae Radix et Rhizoma against human diseases based on activation of Nrf2-mediated antioxidant defense system …
- Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators
- Reduced Nrf2 activation in PI3K phosphorylation‐impaired vitiliginous keratinocytes increases susceptibility to ROS‐generating chemical‐induced apoptosis
- Ethanol Extract of Centipeda minima Exerts Antioxidant and Neuroprotective Effects via Activation of the Nrf2 Signaling Pathway
- Activation of the Nrf2/ARE signaling pathway by probucol contributes to inhibiting inflammation and neuronal apoptosis after spinal cord injury
- Rapamycin protects against paraquat-induced pulmonary fibrosis: activation of Nrf2 signaling pathway
- Activation of Nrf2 by sulforaphane inhibits high glucose-induced progression of pancreatic cancer via AMPK dependent signaling
- Pterostilbene decreases cardiac oxidative stress and inflammation via activation of AMPK/Nrf2/HO-1 pathway in fructose-fed diabetic rats
- Andrographolide protects chondrocytes from oxidative stress injury by activation of the Keap1–Nrf2–Are signaling pathway
- Calycosin suppresses expression of pro-inflammatory cytokines via the activation of p62/Nrf2-linked heme oxygenase 1 in rheumatoid arthritis synovial fibroblasts
- Anti-inflammatory activity of myricetin from Diospyros lotus through suppression of NF-κB and STAT1 activation and Nrf2-mediated HO-1 induction in …
- Magnesium lithospermate B protects the endothelium from inflammation-induced dysfunction through activation of Nrf2 pathway
- Protective effect of phloroglucinol on oxidative stress-induced DNA damage and apoptosis through activation of the Nrf2/HO-1 signaling pathway in HaCaT human …
- Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL/6 models of bronchopulmonary dysplasia
- Xueshuantong Injection (Lyophilized) Attenuates Cerebral Ischemia/Reperfusion Injury by the Activation of Nrf2–VEGF Pathway
- Resveratrol represses estrogen-induced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation
- 3H-1, 2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling
- Activation of Nrf2 reduces UVA-mediated MMP-1 upregulation via MAPK/AP-1 signaling cascades: the photoprotective effects of sulforaphane and hispidulin
- … alterations in a mouse cardiac model of Friedreich ataxia: an impaired Nrf2 response mediated via upregulation of Keap1 and activation of the Gsk3β axis
- Nrf2 pathway activation upon rotenone treatment in human iPSC-derived neural stem cells undergoing differentiation towards neurons and astrocytes
- Activation of Keap1-Nrf2 signaling by 4-octyl itaconate protects human umbilical vein endothelial cells from high glucose
- Protective effects of fucoxanthin against alcoholic liver injury by activation of Nrf2-mediated antioxidant defense and inhibition of TLR4-mediated inflammation
- Activation of Nrf2 attenuates delayed gastric emptying in obesity induced diabetic (T2DM) female mice
- Nrf2 downregulates zymosan-induced neutrophil activation and modulates migration
- Hepatocyte-protective effect of nectandrin B, a nutmeg lignan, against oxidative stress: Role of Nrf2 activation through ERK phosphorylation and AMPK-dependent …
- N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1α/JNK signaling and nuclear Nrf2 activation
- Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro
- Propofol induces proliferation partially via downregulation of p53 protein and promotes migration via activation of the Nrf2 pathway in human breast cancer …
- Ethanol extract of Ganoderma lucidum augments cellular anti-oxidant defense through activation of Nrf2/HO-1
- Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated …
- Hyperoside attenuates dextran sulfate sodium-induced colitis in mice possibly via activation of the Nrf2 signalling pathway
- Protective effect of Nrf2–ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson’s disease model
- Amelioration of oxidative stress in Caco-2 cells treated with pro-inflammatory proteins by chlorogenic acid isomers via activation of the Nrf2–Keap1–ARE-signaling …
- Dexmedetomidine alleviates hepatic injury via the inhibition of oxidative stress and activation of the Nrf2/HO-1 signaling pathway
- … alleviates lipopolysaccharide and D-galactosamine-induced acute liver injury by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation
- Renal toxicity through AhR, PXR, and Nrf2 signaling pathway activation of ochratoxin A-induced oxidative stress in kidney cells
- Triptolide attenuates myocardial ischemia/reperfusion injuries in rats by inducing the activation of Nrf2/HO-1 defense pathway
- Hyperoside alleviated N-acetyl-para-amino-phenol-induced acute hepatic injury via Nrf2 activation
- Activation of Nrf2/HO-1 signal with Myricetin for attenuating ECM degradation in human chondrocytes and ameliorating the murine osteoarthritis
- Quercetin and its metabolites protect hepatocytes against ethanol-induced oxidative stress by activation of Nrf2 and AP-1
- Salvianolic acid A protects against oxidative stress and apoptosis induced by intestinal ischemia-reperfusion injury through activation of Nrf2/HO-1 pathways
- Ulinastatin protects against CVB3-induced acute viral myocarditis through Nrf2 activation
- Organic dust, causing both oxidative stress and Nrf2 activation, is phagocytized by bronchial epithelial cells
- Epigallocatechin-3-gallate enhances radiation sensitivity in colorectal cancer cells through Nrf2 activation and autophagy
- … effects of esculetin against oxidative stress are associated with the upregulation of Nrf2-mediated NQO1 expression via the activation of the ERK pathway
- Ginsenoside Rg1 protects cardiomyocytes against hypoxia/reoxygenation injury via activation of Nrf2/HO-1 signaling and inhibition of JNK
- Orientin-mediated Nrf2/HO-1 signal alleviates H2O2-induced oxidative damage via induction of JNK and PI3K/AKT activation
- The protective role of vitamin D3 in a murine model of asthma via the suppression of TGF-β/Smad signaling and activation of the Nrf2/HO-1 pathway
- Concomitant Nrf2-and ATF4-activation by carnosic acid cooperatively induces expression of cytoprotective genes
- Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFĸB/AKT/mTOR/KEAP1 signalling in rat …
- Investigation of Nrf2, AhR and ATF4 activation in toxicogenomic databases
- Activation of Nrf2 signaling as a common treatment of neurodegenerative diseases
- Anthocyanin delphinidin prevents neoplastic transformation of mouse skin JB6 P+ cells: epigenetic re-activation of Nrf2-ARE pathway
- Recurrent loss of NFE2L2 exon 2 is a mechanism for Nrf2 pathway activation in human cancers
- α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway
- Activation of Nrf2 by phloretin attenuates palmitic acid-induced endothelial cell oxidative stress via AMPK-dependent signaling
- Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice
- Sulforaphane protects granulosa cells against oxidative stress via activation of NRF2-ARE pathway
- Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways
- … action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/Antioxidant enzyme in …
- Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress
- Irisin pretreatment ameliorates intestinal ischemia/reperfusion injury in mice through activation of the Nrf2 pathway
- Notoginsenoside R1 ameliorates diabetic encephalopathy by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation
- Aspirin induces Nrf2‐mediated transcriptional activation of haem oxygenase‐1 in protection of human melanocytes from H2O2‐induced oxidative stress
- Asbestos induces oxidative stress and activation of Nrf2 signaling in murine macrophages: chemopreventive role of the synthetic lignan secoisolariciresinol …
- Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and …
- JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2
- Hydrogen-rich water intake accelerates oral palatal wound healing via activation of the Nrf2/antioxidant defense pathways in a rat model
- Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2
- Sulforaphane prevents methylmercury-induced oxidative damage and excitotoxicity through activation of the Nrf2-ARE pathway
- Propolis reversed cigarette smoke-induced emphysema through macrophage alternative activation independent of Nrf2
- Mulberry crude extracts induce Nrf2 activation and expression of detoxifying enzymes in rat liver: Implication for its protection against NP-induced toxic effects
- … rhamnosus GG and its supernatant against myocardial dysfunction in obese mice exposed to intermittent hypoxia is associated with the activation of Nrf2 …
- Hesperidin attenuates learning and memory deficits in APP/PS1 mice through activation of Akt/Nrf2 signaling and inhibition of RAGE/NF-κB signaling
- NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation
- Protective effect of hyperoside on cardiac ischemia reperfusion injury through inhibition of ER stress and activation of Nrf2 signaling
- Mechanism of rapid nuclear factor-E2-related factor 2 (Nrf2) activation via membrane-associated estrogen receptors: roles of NADPH oxidase 1, neutral …
- FGF19 protects hepatocellular carcinoma cells against endoplasmic reticulum stress via activation of FGFR4–GSK3β–Nrf2 signaling
- Grape peel extract and resveratrol inhibit wrinkle formation in mice model through activation of Nrf2/HO‐1 signaling pathway
- Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of baicalein against oxidative stress-induced DNA damage and apoptosis in …
- Activation of Nrf2-mediated anti-oxidant genes by antrodin C prevents hyperglycemia-induced senescence and apoptosis in human endothelial cells
- MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury
- Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats
- Oncogenic activation of Nrf2, though as a master antioxidant transcription factor, liberated by specific knockout of the full-length Nrf1α that acts as a dominant tumor …
- Activation of autophagic flux and the Nrf2/ARE signaling pathway by hydrogen sulfide protects against acrylonitrile-induced neurotoxicity in primary rat astrocytes
- Activation of Nrf2/HO-1 pathway by glycogen synthase kinase-3β inhibition attenuates renal ischemia/reperfusion injury in diabetic rats
- Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2
- Antioxidants cinnamaldehyde and Galactomyces fermentation filtrate downregulate senescence marker CDKN2A/p16INK4A via NRF2 activation in keratinocytes
- Activation of Nrf2 signaling by Icariin protects against 6‐OHDA‐induced neurotoxicity
- Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies
- The bright side of plasmonic gold nanoparticles; activation of Nrf2, the cellular protective pathway
- Activation of Nrf2 contributes to the protective effect of Exendin-4 against angiotensin II-induced vascular smooth muscle cell senescence
- Dehydroepiandrosterone alleviates oxidative stress and apoptosis in iron-induced epilepsy via activation of Nrf2/ARE signal pathway
- Soybean-derived phytoalexins improve cognitive function through activation of Nrf2/HO-1 signaling pathway
- Mechanisms of NRF2 activation to mediate fetal hemoglobin induction and protection against oxidative stress in sickle cell disease
- Isoliquiritigenin protects against triptolide-induced hepatotoxicity in mice through Nrf2 activation
- Aucubin, a natural iridoid glucoside, attenuates oxidative stress-induced testis injury by inhibiting JNK and CHOP activation via Nrf2 up-regulation
- Lycopene inhibits NF-κB activation and adhesion molecule expression through Nrf2-mediated heme oxygenase-1 in endothelial cells
- Nrf2 activation inhibits effects of thrombin in human amnion cells and thrombin-induced preterm birth in mice
- Melatonin protects against arsenic trioxide-induced liver injury by the upregulation of Nrf2 expression through the activation of PI3K/AKT pathway
- … efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38
- Artemether Activation of AMPK/GSK3β(ser9)/Nrf2 Signaling Confers Neuroprotection towards β-Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse …
- Novel protective mechanism of reducing renal cell damage in diabetes: activation AMPK by AICAR increased NRF2/OGG1 proteins and reduced oxidative DNA …
- Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis
- Autophagy involved in the activation of the Nrf2-antioxidant system in testes of heat-exposed mice
- Activation of anti-oxidant of curcumin pyrazole derivatives through preservation of mitochondria function and Nrf2 signaling pathway
- Protective effects of curcumin against mercury-induced hepatic injuries in rats, involvement of oxidative stress antagonism, and Nrf2-ARE pathway activation
- … M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1
- Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation
- Naringenin Ameliorates Behavioral Dysfunction and Neurological Deficits in a d-Galactose-Induced Aging Mouse Model Through Activation of PI3K/Akt/Nrf2 Pathway
- Transcriptional activation of follistatin by Nrf2 protects pulmonary epithelial cells against silica nanoparticle-induced oxidative stress
- Neferine prevents autophagy induced by hypoxia through activation of Akt/mTOR pathway and Nrf2 in muscle cells
- Anti-neuroinflammatory Activity of Elephantopus scaber L. via Activation of Nrf2/HO-1 Signaling and Inhibition of p38 MAPK Pathway in LPS-Induced …
- … A4 restores oxidative stress-induced vascular endothelial cell injury and thrombosis-related factor expression by its receptor-mediated activation of Nrf2-HO-1 axis
- Synthesis of new ferulic/lipoic/comenic acid-melatonin hybrids as antioxidants and Nrf2 activators via Ugi reaction
- Inhibiting adhesion events by Panax notoginseng saponins and Ginsenoside Rb1 protecting arteries via activation of Nrf2 and suppression of p38–VCAM-1 signal …
- The association between oxidative stress alleviation via sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation and chronic renal allograft …
- Neglected role of hydrogen sulfide in sulfur mustard poisoning: Keap1 S-sulfhydration and subsequent Nrf2 pathway activation
- Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascade
- Berberine protects immortalized line of human melanocytes from H2O2-induced oxidative stress via activation of Nrf2 and Mitf signaling pathway
- Sageretia thea Inhibits Inflammation through Suppression of NF-B and MAPK and Activation of Nrf2/HO-1 Signaling Pathways in RAW264.7 Cells
- Inhibition of autophagy reverses alcohol-induced hepatic stellate cells activation through activation of Nrf2-Keap1-ARE signaling pathway
- Anti-inflammatory effect of erinacine C on NO production through down-regulation of NF-κB and activation of Nrf2-mediated HO-1 in BV2 microglial cells treated with …
- … action of tea polyphenols on oxidative stress-induced apoptosis through the activation of the TrkB/CREB/BDNF pathway and Keap1/Nrf2 signaling pathway in SH …
- Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway
- Co–Cr dental alloys induces cytotoxicity and inflammatory responses via activation of Nrf2/antioxidant signaling pathways in human gingival fibroblasts and …
- Eriodictyol attenuates arsenic trioxide-induced liver injury by activation of Nrf2
- L-carnitine regulated Nrf2/Keap1 activation in vitro and in vivo and protected oxidized fish oil-induced inflammation response by inhibiting the NF-κB signaling …
- Celastrol attenuates angiotensin II mediated human umbilical vein endothelial cells damage through activation of Nrf2/ERK1/2/Nox2 signal pathway
- Asiatic acid ameliorates doxorubicin-induced cardiac and hepato-renal toxicities with Nrf2 transcriptional factor activation in rats
- Diallyl trisulfide suppresses tumor growth through the attenuation of Nrf2/Akt and activation of p38/JNK and potentiates cisplatin efficacy in gastric cancer …
- Salidroside protects against bleomycin-induced pulmonary fibrosis: activation of Nrf2-antioxidant signaling, and inhibition of NF-κB and TGF-β1/Smad-2/-3 pathways
- Preconditioning by low dose LPS prevents subsequent LPS-induced severe liver injury via Nrf2 activation in mice
- Activation of Nrf2 by MIND4-17 protects osteoblasts from hydrogen peroxide-induced oxidative stress
- Aspirin suppresses neuronal apoptosis, reduces tissue inflammation, and restrains astrocyte activation by activating the Nrf2/HO-1 signaling pathway
- Activation of Nrf2 and hypoxic adaptive response contribute to neuroprotection elicited by phenylhydroxamic acid selective HDAC6 inhibitors
- Polydatin protects against acute myocardial infarction-induced cardiac damage by activation of Nrf2/HO-1 signaling
- Antiviral effect of 7-(4-benzimidazole-butoxy)-coumarin on rhabdoviral clearance via Nrf2 activation regulated by PKCα/β phosphorylation
- Dietary oleuropein and its new acyl-derivate attenuate murine lupus nephritis through HO-1/Nrf2 activation and suppressing JAK/STAT, NF-κB, MAPK and NLRP3 …
- Helenalin from Centipeda minima ameliorates acute hepatic injury by protecting mitochondria function, activating Nrf2 pathway and inhibiting NF-κB activation
- Sodium valproate prevents radiation-induced injury in hippocampal neurons via activation of the Nrf2/HO-1 pathway
- Activation of the Nrf2 signaling pathway involving KLF9 plays a critical role in allicin resisting against arsenic trioxide-induced hepatotoxicity in rats
- … of Nrf2-mediated heme oxygenase-1 expression in anti-inflammatory action of chitosan oligosaccharides through MAPK activation in murine macrophages
- Anthraquinone and naphthopyrone glycosides from Cassia obtusifolia seeds mediate hepatoprotection via Nrf2-mediated HO-1 activation and MAPK modulation
- Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells
- Benznidazole, the trypanocidal drug used for Chagas disease, induces hepatic NRF2 activation and attenuates the inflammatory response in a murine model of sepsis
- Andrographolide protects PC12 cells against β-amyloid-induced autophagy-associated cell death through activation of the Nrf2-mediated p62 signaling pathway
- Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory …
- Retracted: Activation of the Nrf2‐ARE Signaling Pathway Prevents Hyperphosphatemia‐Induced Vascular Calcification by Inducing Autophagy in Renal Vascular …
- Proanthocyanidins antagonize arsenic-induced oxidative damage and promote arsenic methylation through activation of the Nrf2 signaling pathway
- Ameliorating mitochondrial dysfunction restores carbon ion-induced cognitive deficits via co-activation of NRF2 and PINK1 signaling pathway
- Xiaochaihutang inhibits the activation of hepatic stellate cell line T6 through the Nrf2 pathway
- Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the …
- Effects of 3‐Bromo‐4, 5‐dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase‐1 Expression
- 20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 …
- Two sesquiterpene aminoquinones protect against oxidative injury in HaCaT keratinocytes via activation of AMPKα/ERK-Nrf2/ARE/HO-1 signaling
- Forsythiaside A protects against focal cerebral ischemic injury by mediating the activation of the Nrf2 and endoplasmic reticulum stress pathways
- Taurine protects mouse spermatocytes from ionizing radiation-induced damage through activation of Nrf2/HO-1 signaling
- … protective effect of the total flavonoids of Abelmoschus esculentus L. flowers on transient cerebral ischemia-reperfusion injury is due to activation of the Nrf2 …
- Pterostilbene protects against uraemia serum-induced endothelial cell damage via activation of Keap1/Nrf2/HO-1 signaling
- Spica prunellae and its marker compound rosmarinic acid induced the expression of efflux transporters through activation of Nrf2-mediated signaling pathway in …
- Chrysin attenuates carrageenan-induced pleurisy and lung injury via activation of SIRT1/NRF2 pathway in rats
- … -induced cardiotoxicity and genotoxicity by an indole-based natural compound 3, 3′-diindolylmethane (DIM) through activation of Nrf2/ARE signaling pathways and …
- Lycopene ameliorates atrazine-induced oxidative damage in adrenal cortex of male rats by activation of the Nrf2/HO-1 pathway
- Targeting crosstalk between Nuclear factor (erythroid-derived 2)-like 2 and Nuclear factor kappa beta pathway by Nrf2 activator dimethyl fumarate in epileptogenesis
- A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway
- The antidepressant-like effect of guanosine is dependent on GSK-3β inhibition and activation of MAPK/ERK and Nrf2/heme oxygenase-1 signaling pathways
- Activation of the Nrf2-ARE pathway ameliorates hyperglycemia-mediated mitochondrial dysfunction in podocytes partly through Sirt1
- Kinsenoside ameliorates intervertebral disc degeneration through the activation of AKT-ERK1/2-Nrf2 signaling pathway
- Tryptanthrin suppresses the activation of the LPS-treated BV2 microglial cell line via Nrf2/HO-1 antioxidant signaling
- TGF-β and Hypoxia/Reoxygenation Promote Radioresistance of A549 Lung Cancer Cells through Activation of Nrf2 and EGFR
- Boric acid activation of eIF2α and Nrf2 is PERK dependent: a mechanism that explains how boron prevents DNA damage and enhances antioxidant status
- Drug screens of NGLY1 deficiency in worm and fly models reveal catecholamine, NRF2 and anti-inflammatory-pathway activation as potential clinical approaches
- Kiwi fruit (Actinidia deliciosa) ameliorates gentamicin-induced nephrotoxicity in albino mice via the activation of Nrf2 and the inhibition of NF-κB (Kiwi & gentamicin …
- Activation of Nrf2/ARE signaling pathway attenuates lanthanum chloride induced injuries in primary rat astrocytes
- Simultaneous activation of Nrf2 and elevation of dietary and endogenous antioxidant chemicals for cancer prevention in humans
- … regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient …
- 4-Hydroperoxy-2-decenoic acid ethyl ester protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways
- Equol attenuates atherosclerosis in apolipoprotein E-deficient mice by inhibiting endoplasmic reticulum stress via activation of Nrf2 in endothelial cells
- L-ascorbic acid and α-tocopherol attenuate arsenic trioxide-induced toxicity in H9c2 cardiomyocytes by the activation of Nrf2 and Bcl2 transcription factors
- Activation of the Nrf2-ARE signal pathway after blast induced traumatic brain injury in mice
- … cytoprotective effects against oxidative stress in C2C12 myoblasts via the upregulation of Nrf2-dependent HO-1 expression and the activation of the ERK …
- TTB Protects Astrocytes Against Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury via Activation of Nrf2/HO-1 Signaling Pathway
- Dynorphin activation of kappa opioid receptor protects against epilepsy and seizure-induced brain injury via PI3K/Akt/Nrf2/HO-1 pathway
- Pomegranate (Punica granatum L.) wine polyphenols affect Nrf2 activation and antioxidant enzyme expression in human neuroblastoma cells (SH-SY5Y)
- Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes
- Ultraviolet B irradiation induced Nrf2 degradation occurs via activation of TRPV1 channels in human dermal fibroblasts
- DADLE improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO‑1 pathway
- … roots inhibit the production of pro-inflammatory mediators through the inhibition of NF-κB and MAPK signaling, and activation of ROS/Nrf2/HO-1 signaling in …
- Soluble P-selectin promotes retinal ganglion cell survival through activation of Nrf2 signaling after ischemia injury
- Z-Guggulsterone attenuates glucocorticoid-induced osteoporosis through activation of Nrf2/HO-1 signaling
- Low-dose dose–response for in vitro Nrf2-ARE activation in human HepG2 cells
- Inhibition of JNK and activation of the AMPK-Nrf2 axis by corosolic acid suppress osteolysis and oxidative stress
- Lipoicmethylenedioxyphenol reduces experimental atherosclerosis through activation of Nrf2 signaling
- TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer
- Sigma-1 receptor activation ameliorates LPS-induced NO production and ROS formation through the Nrf2/HO-1 signaling pathway in cultured astrocytes
- 5‐Aminolevulinic acid exerts renoprotective effect via Nrf2 activation in murine rhabdomyolysis‐induced acute kidney injury
- Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition
- Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate
- Pharmacogenomics of chemically distinct classes of Keap1-Nrf2 activators identify common and unique gene, protein, and pathway responses in vivo
- Remote limb ischaemic postconditioning protects against myocardial ischaemia/reperfusion injury in mice: activation of JAK/STAT3-mediated Nrf2-antioxidant …
- Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1
- A new BEACON of hope for the treatment of inflammation? The endogenous metabolite itaconate as an alternative activator of the KEAP1-Nrf2 system
- Obeticholic acid protects against diabetic cardiomyopathy by activation of FXR/Nrf2 signaling in db/db mice
- Cytoprotective effects of diosmetin against hydrogen peroxide-induced L02 cell oxidative damage via activation of the Nrf2-ARE signaling pathway
- Proteomics analysis of dendritic cell activation by contact allergens reveals possible biomarkers regulated by Nrf2
- The protective role of tanshinone IIA in silicosis rat model via TGF-β1/Smad signaling suppression, NOX4 inhibition and Nrf2/ARE signaling activation
- Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of coptisine against oxidative stress-induced DNA damage and apoptosis in HaCaT …
- Isobavachalcone attenuates Sephadex-induced lung injury via activation of A20 and NRF2/HO-1 in rats
- Ciliary neurotrophic factor (CNTF) protects myocardial cells from oxygen glucose deprivation (OGD)/re-oxygenation via activation of Akt-Nrf2 signaling
- The Bcl‐2 inhibitor venetoclax inhibits Nrf2 antioxidant pathway activation induced by hypomethylating agents in AML
- … tiliroside derivative, 3-O-[(E)-(2-oxo-4-(p-tolyl) but–3–en–1–yl] kaempferol produced inhibition of neuroinflammation and activation of AMPK and Nrf2/HO-1 pathways …
- Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling
- RETRACTED ARTICLE: Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture
- … fields reduces neuroinflammation and ameliorates scopolamine-induced amnesia in mouse brain through its antioxidant ability via Nrf2-HO-1 activation
- Protective properties of Huperzine A through activation Nrf2/ARE‐mediated transcriptional response in X‐rays radiation‐induced NIH3T3 cells
- … stem cells combined with plumbagin alleviates spinal cord injury by affecting oxidative stress, inflammation, apoptotis and the activation of the Nrf2 pathway
- Aldehyde dehydrogenase 2 activation ameliorates CCl4‐induced chronic liver fibrosis in mice by up‐regulating Nrf2/HO‐1 antioxidant pathway
- Activation of the Nrf2/HO-1 Signaling Pathway Contributes to the Protective Effects of Sargassum serratifolium Extract against Oxidative Stress-Induced DNA …
- Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis in rats via anti-inflammatory and activation of the Nrf2 pathway
- Spleen tyrosine kinase-dependent Nrf2 activation regulates oxidative stress-induced cell death in WiL2-NS human B lymphoblasts
- Punicalagin protects H9c2 cardiomyocytes from doxorubicin-induced toxicity through activation of Nrf2/HO-1 signaling
- The angiotensin‐(1‐7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation
- Carnosic acid protects mitochondria of human neuroblastoma SH-SY5Y cells exposed to paraquat through activation of the Nrf2/HO-1Axis
- l-carnitine protects human hepatocytes from oxidative stress-induced toxicity through Akt-mediated activation of Nrf2 signaling pathway
- Circadian control of p75 neurotrophin receptor leads to alternate activation of Nrf2 and c-Rel to reset energy metabolism in astrocytes via brain-derived neurotrophic …
- Anti-inflammatory effect of sulforaphane on LPS-activated microglia potentially through JNK/AP-1/NF-κB inhibition and Nrf2/HO-1 activation
- HX‐1171, a Novel Nrf2 Activator, Induces NQO1 and HMOX1 Expression
- Repetitive exposure to low-dose X-irradiation attenuates testicular apoptosis in type 2 diabetic rats, likely via Akt-mediated Nrf2 activation
- Nrf2-Keap1 activation, a promising strategy in the prevention of cancer
- … TXNIP mediated NLRP3 inflammasome activation in MSU crystal stimulated RAW 264.7 macrophages through the upregulation of Nrf2 transcription factor and …
- Up-regulation of HO-1 by Nrf2 activation protects against palmitic acid-induced ROS increase in human neuroblastoma BE (2)-M17 cells
- Downregulation of Bach1 protects osteoblasts against hydrogen peroxide-induced oxidative damage in vitro by enhancing the activation of Nrf2/ARE signaling
- The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation
- Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression
- Neuroprotective effect of fermented papaya preparation by activation of Nrf2 pathway in astrocytes
- Glycyrrhizin protects against sodium iodate‐induced RPE and retinal injury though activation of AKT and Nrf2/HO‐1 pathway
- Association of Neuroprotective Effect of Di-O-Demethylcurcumin on Aβ25–35-Induced Neurotoxicity with Suppression of NF-κB and Activation of Nrf2
- Vanadium(III)-L-cysteine protects cisplatin-induced nephropathy through activation of Nrf2/HO-1 pathway
- Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of …
- 3-NP-induced Huntington’s-like disease impairs Nrf2 activation without loss of cardiac function in aged rats
- Curcumin prevents high glucose damage in retinal pigment epithelial cells through ERK1/2‐mediated activation of the Nrf2/HO‐1 pathway
- Recuperating lung decoction attenuates inflammation and oxidation in cigarette smoke‐induced COPD in rats via activation of ERK and Nrf2 pathways
- Aloin reduces HMGB1-mediated septic responses and improves survival in septic mice by activation of the SIRT1 and PI3K/Nrf2/HO-1 signaling axis
- Activation of the Nrf2-Keap 1 pathway in short-term iodide excess in thyroid in rats
- … injury in patients with rheumatic valvular heart disease undergoing CPB surgery are associated with the suppression of NF‐κB pathway and the activation of Nrf2 …
- Lansoprazole halts contrast induced nephropathy through activation of Nrf2 pathway in rats
- Activation of autophagy and Nrf2 signaling in human breast adenocarcinoma MCF-7 cells by novel monophenolic antioxidants
- Melatonin protects H9c2 cells against ischemia/reperfusion‑induced apoptosis and oxidative stress via activation of the Nrf2 signaling pathway
- Prunus Mahaleb Fruit Extract Prevents Chemically Induced Colitis and Enhances Mitochondrial Oxidative Metabolism via the Activation of the Nrf2 Pathway
- Lycopene attenuates AFB 1-induced renal injury with the activation of the Nrf2 antioxidant signaling pathway in mice
- Amelioratory effects of testosterone propionate on age-related renal fibrosis via suppression of TGF-β1/Smad signaling and activation of Nrf2-ARE signaling
- Sulforaphane ameliorates bladder dysfunction through activation of the Nrf2-ARE pathway in a rat model of partial bladder outlet obstruction
- Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death
- Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain
- Glucose oxidase facilitates osteogenic differentiation and mineralization of embryonic stem cells through the activation of Nrf2 and ERK signal transduction pathways
- Co-activation of PKC-δ by CRIF1 modulates oxidative stress in bone marrow multipotent mesenchymal stromal cells after irradiation by phosphorylating NRF2 …
- Probucol improves erectile function via Activation of Nrf2 and coordinates the HO-1/DDAH/PPAR-γ/eNOS pathways in streptozotocin-induced diabetic rats
- Protective effects of diallyl sulfide on ovalbumin-induced pulmonary inflammation of allergic asthma mice by microRNA-144,-34a, and-34b/c-modulated Nrf2 activation
- Sodium tanshinone IIA sulfonate suppresses pulmonary fibroblast proliferation and activation induced by silica: role of the Nrf2/Trx pathway
- Gambogic acid induces heme oxygenase-1 through Nrf2 signaling pathway and inhibits NF-κB and MAPK activation to reduce inflammation in LPS-activated …
- Methyleugenol protects against t-BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3β and ERK activation
- Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2–ARE pathway
- Ziziphus spina-christi Leaf Extract Suppressed Mercury Chloride-Induced Nephrotoxicity via Nrf2-Antioxidant Pathway Activation and Inhibition of …
- Hesperetin suppresses inflammatory responses in lipopolysaccharide-induced RAW 264.7 cells via the inhibition of NF-κB and activation of Nrf2/HO-1 pathways
- Suppression of 6-hydroxydopamine-induced oxidative stress by hyperoside via activation of Nrf2/HO-1 signaling in dopaminergic neurons
- … of periostin prevents high glucose-induced mitochondrial apoptosis in human umbilical vein endothelial cells via activation of Nrf2/HO-1 signaling
- Nrf2 activation ameliorates hepatotoxicity induced by a heme synthesis inhibitor
- … serratifolium attenuates RANKL-induced osteoclast differentiation and oxidative stress through inhibition of NF-κB and activation of the Nrf2/HO-1 signaling pathway
- Structured DAG oil ameliorates renal injury in streptozotocin-induced diabetic rats through inhibition of NF-κB and activation of Nrf2 pathway
- Melittin ameliorates CVB3-induced myocarditis via activation of the HDAC2-mediated GSK-3β/Nrf2/ARE signaling pathway
- Enhancement of dopaminergic activity and region-specific activation of Nrf2-ARE pathway by intranasal supplements of testosterone propionate in aged male rats
- Astragaloside IV and ferulic acid synergistically promote neurite outgrowth through Nrf2 activation
- Lignans from Saururus chinensis exhibit anti-inflammatory activity by influencing the Nrf2/HO-1 activation pathway
- Anticancer activity of Honokiol against lymphoid malignant cells via activation of ROS-JNK and attenuation of Nrf2 and NF-κB
- Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in …
- … human dopamine D5 receptor mutation in mice causes a dilated cardiomyopathy through ROS over-generation by NADPH oxidase activation and Nrf2 …
- Activation of Nrf2/HO-1 pathway protects retinal ganglion cells from a rat chronic ocular hypertension model of glaucoma
- … chinensis total lignans on acute alcoholic-induced liver injury related to inhibiting CYP2E1 activation and activating the Nrf2/ARE signaling pathway
- Umbilical cord MSCs reverse D-galactose-induced hepatic mitochondrial dysfunction via activation of Nrf2/HO-1 pathway
- LL202 ameliorates colitis against oxidative stress of macrophage by activation of the Nrf2/HO‐1 pathway
- … from the edible marine algae Padina tetrastromatica attenuates isoproterenol-induced oxidative damage via activation of PI3K/Akt/Nrf2 signaling pathway-an in vitro …
- Stevia rebaudiana tea prevents experimental cirrhosis via regulation of NF‐κB, Nrf2, transforming growth factor beta, Smad7, and hepatic stellate cell activation
- Keap1 cystenine 151 as a potential target for artemisitene-induced Nrf2 activation
- Activation of cannabinoid type 2 receptor protects skeletal muscle from ischemia-reperfusion injury partly via Nrf2 signaling
- Nrf2 activation via Keap1 deletion or sulforaphane treatment reduces Ova-induced sinonasal inflammation
- Gedunin Inhibits Oligomeric Aβ1–42-Induced Microglia Activation Via Modulation of Nrf2-NF-κB Signaling
- GYY4137 protects against myocardial ischemia/reperfusion injury via activation of the PHLPP-1/Akt/Nrf2 signaling pathway in diabetic mice
- … multi-herbal medicine kyung-ok-ko in an animal model of Parkinson’s disease: inhibition of MAPKs and NF-κB pathways and activation of keap1-Nrf2 …
- Nanoceria restrains PM2. 5-induced metabolic disorder and hypothalamus inflammation by inhibition of astrocytes activation related NF-κB pathway in Nrf2 deficient …
- Saikosaponin a inhibits cigarette smoke-induced oxidant stress and inflammatory responses by activation of Nrf2
- Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway
- The Ethanol Extract of Licorice (Glycyrrhiza uralensis) Protects against Triptolide-Induced Oxidative Stress through Activation of Nrf2
- Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression
- … Velvet Antler (Cervus elaphus) against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPK/NF-κB Activation and Inducing AMPK/Nrf2 …
- Cyanidin-3-O-glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation
- Dimethyl fumarate accelerates peripheral nerve regeneration via activation of the anti-inflammatory and cytoprotective Nrf2/HO-1 signaling pathway
- Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 …
- HO‑1 alleviates cholesterol‑induced oxidative stress through activation of Nrf2/ERK and inhibition of PI3K/AKT pathways in endothelial cells
- Homoeriodictyol protects human endothelial cells against oxidative insults through activation of Nrf2 and inhibition of mitochondrial dysfunction
- Ginsenoside re inhibits ROS/ASK-1 dependent mitochondrial apoptosis pathway and activation of Nrf2-antioxidant response in beta-amyloid-challenged SH-SY5Y …
- Hepatocellular iNOS protects liver from NASH through Nrf2-dependent activation of HO-1
- Peanut arachidin-1 enhances Nrf2-mediated protective mechanisms against TNF-α-induced ICAM-1 expression and NF-κB activation in endothelial cells
- Herbal formula SC-E1 suppresses lipopolysaccharide-stimulated inflammatory responses through activation of Nrf2/HO-1 signaling pathway in RAW 264.7 …
- … -methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti-oxidative …
- Diallyl sulfide attenuates transforming growth factor-β-stimulated pulmonary fibrosis through Nrf2 activation in lung MRC-5 fibroblast
- … -gallate ameliorates angiotensin II-induced oxidative stress and apoptosis in human umbilical vein endothelial cells through the activation of Nrf2/caspase-3 signaling
- Early antioxidant responses via the concerted activation of NF-κB and Nrf2 characterize the gamma-radiation-induced adaptive response in quiescent human …
- Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2/HO-1 axis in SH-SY5Y cells
- Mechanism of Emulsified Isoflurane Postconditioning–Induced Activation of the Nrf2–Antioxidant Response Element Signaling Pathway During Myocardial Ischemia …
- Trans-cinnamic acid attenuates UVA-induced photoaging through inhibition of AP-1 activation and induction of Nrf2-mediated antioxidant genes in human skin …
- Rosmarinic acid counteracts activation of hepatic stellate cells via inhibiting the ROS-dependent MMP-2 activity: Involvement of Nrf2 antioxidant system
- Contrasting effects of a classic Nrf2 activator, tert-butylhydroquinone, on the glutathione-related antioxidant defenses in Pacific oysters, Crassostrea gigas
- CRISPR/Cas9 editing of glia maturation factor regulates mitochondrial dynamics by attenuation of the NRF2/HO-1 dependent ferritin activation in glial cells
- Astragaloside IV attenuates lead acetate-induced inhibition of neurite outgrowth through activation of Akt-dependent Nrf2 pathway in vitro
- Oncogenic mutations in KEAP1 disturbing inhibitory Nrf2‐Keap1 interaction: Activation of antioxidative pathway in papillary thyroid carcinoma
- Sulforaphane prevents angiotensin II-induced testicular cell death via activation of NRF2
- Anti-inflammatory activity of 8-hydroxydaidzein in LPS-stimulated BV2 microglial cells via activation of Nrf2-antioxidant and attenuation of Akt/NF-κB-inflammatory …
- Cyanidin‐3‐glucoside and its phenolic acid metabolites attenuate visible light‐induced retinal degeneration in vivo via activation of Nrf2/HO‐1 pathway and NF‐κB …
- Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of LPS-induced inflammation and redox imbalance: Evidence from in …
- Methionine sulfoxide reductase B3 deficiency stimulates heme oxygenase-1 expression via ROS-dependent and Nrf2 activation pathways
- α-Cyperone inhibits LPS-induced inflammation in BV-2 cells through activation of Akt/Nrf2/HO-1 and suppression of the NF-κB pathway
- Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway
- … effects of oxymatrine against lipopolysaccharide/D‑galactosamine‑induced acute liver failure through oxidative damage, via activation of Nrf2/HO‑1 and …
- Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway
- Transcriptional regulation of Hb‐α and Hb‐β through nuclear factor E2‐related factor‐2 (Nrf2) activation in human vaginal cells: A novel mechanism of cellular …
- DHA and vitamin e antagonized the Aβ 25–35-mediated neuron oxidative damage through activation of Nrf2 signaling pathways and regulation of CD36, SRB1 and …
- Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling
- … and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane’s antioxidant response element activation, even as they suppress Nrf2 …
- 7-deacetylgedunin suppresses inflammatory responses through activation of Keap1/Nrf2/HO-1 signaling
- Piceatannol protects ARPE-19 cells against vitamin A dimer-mediated photo-oxidative damage through activation of Nrf2/NQO1 signalling
- … extract of Prunus mume fruit attenuates hydrogen peroxide-induced oxidative stress and apoptosis involving Nrf2/HO-1 activation in C2C12 myoblasts
- Apigenin attenuates oxidative injury in ARPE-19 cells thorough activation of Nrf2 pathway
- HX-1171 attenuates pancreatic β-cell apoptosis and hyperglycemia-mediated oxidative stress via Nrf2 activation in streptozotocin-induced diabetic model
- Therapeutic effect of Mahaenggamseok-tang on neutrophilic lung inflammation is associated with NF-κB suppression and Nrf2 activation
- Isoflavone biochanin A, a novel nuclear factor erythroid 2‐related factor 2 (Nrf2)‐antioxidant response element activator, protects against oxidative damage in HepG2 …
- Nardochinoid B inhibited the activation of RAW264. 7 macrophages stimulated by lipopolysaccharide through activating the Nrf2/HO-1 pathway
- Quercetin phospholipid complex significantly protects against oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway
- Propofol post‐conditioning alleviates hepatic ischaemia reperfusion injury via BRG1‐mediated Nrf2/HO‐1 transcriptional activation in human and mice
- Activation of p38MAPK and NRF2 signaling pathways in the toxicity induced by chlorpyrifos in Drosophila melanogaster: protective effects of Psidium guajava …
- n-3 Polyunsaturated fatty acids induce acute myeloid leukemia cell death associated with mitochondrial glycolytic switch and Nrf2 pathway activation
- … prevents nonalcoholic fatty liver disease (NAFLD) and hyperlipidemia via PI3K/AKT-dependent activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in …
- Pinocembrin provides mitochondrial protection by the activation of the Erk1/2-Nrf2 signaling pathway in SH-SY5Y neuroblastoma cells exposed to paraquat
- Celastrol protects RPE cells from oxidative stress-induced cell death via activation of Nrf2 signaling pathway
- Nrf2 knockout: The effect on neurological dysfunction and the activation of glial cells of mice after brain injury.
- Alleviated Oxidative Damage by Taraxacum officinale through the Induction of Nrf2-MAPK/PI3K Mediated HO-1 Activation in Murine Macrophages RAW 264.7 Cell …
- Maresin 1 mitigates renal ischemia/reperfusion injury in mice via inhibition of the TLR4/MAPK/NF-κB pathways and activation of the Nrf2 pathway
- Chronic activation of hepatic Nrf2 has no major effect on fatty acid and glucose metabolism in adult mice
- Epigallocatechin-3-gallate attenuates microcystin-LR-induced apoptosis in human umbilical vein endothelial cells through activation of the NRF2/HO-1 pathway
- Puerarin protects endothelial progenitor cells from damage of angiotensin II via activation of ERK1/2‑Nrf2 signaling pathway
- Redox signaling in ischemic postconditioning protection involves PKCε and Erk1/2 pathways and converges indirectly in Nrf2 activation
- Zinc L-carnosine suppresses inflammatory responses in lipopolysaccharide-induced RAW 264.7 murine macrophages cell line via activation of Nrf2/HO-1 signaling …
- Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells
- Proteasome inhibitor-induced IκB/NF-κB activation is mediated by Nrf2-dependent light chain 3B induction in lung cancer cells
- Cytoprotective effect of Makgeolli lees on paraquat induced oxidative stress in A549 cells via activation of NRF2 and antioxidant genes
- Prevention effect of Ligusticum chuanxiong extraction against oxidative stress injury induced by myocardial ischemia through activation of Nrf2 signaling pathway
- A red pumpkin seed extract reduces melanosome transfer to keratinocytes by activation of Nrf2 signaling
- Berberine upregulates P-glycoprotein in human Caco-2 cells and in an experimental model of colitis in the rat via activation of Nrf2-dependent mechanisms
- Fibroblast growth factor 19 protects the heart from oxidative stress-induced diabetic cardiomyopathy via activation of AMPK/Nrf2/HO-1 pathway
- Pilot-scale produced fermented lentil protects against t-BHP-triggered oxidative stress by activation of Nrf2 dependent on SAPK/JNK phosphorylation
- Mangiferin upregulates glyoxalase 1 through activation of Nrf2/ARE signaling in central neurons cultured with high glucose
- BQ123 stimulates skeletal muscle antioxidant defense via Nrf2 activation in LPS-treated rats
- Melaleuca alternifolia Induces Heme Oxygenase-1 Expression in Murine RAW264.7 Cells through Activation of the Nrf2-ARE Pathway
- Activation of NRF2 by dexamethasone in ataxia telangiectasia cells involves KEAP1 inhibition but not the inhibition of p38
- … 1 ameliorates the neuronal apoptosis and oxidative stress induced by oxygen-glucose deprivation/reoxygenation through activation of Nrf2/HO-1 signaling
- Sake lees hydrolysate protects against acetaminophen-induced hepatotoxicity via activation of the Nrf2 antioxidant pathway
- Effect of repeated daily dosing with 2, 4-dinitrochlorobenzene on glutathione biosynthesis and Nrf2 activation in reconstructed human epidermis
- Genistein attenuates di‑(2‑ethylhexyl) phthalate-induced testicular injuries via activation of Nrf2/HO‑1 following prepubertal exposure
- N-butyl-α-D-fructofuranoside isolated from Ulmus davidiana enhances Nrf2 activity through activation of JNK
- Mitochondrial permeabilization without caspase activation mediates the increase of basal apoptosis in cells lacking Nrf2
- Fraxetin induces heme oxygenase-1 expression by activation of Akt/Nrf2 or AMP-activated protein kinase α/Nrf2 pathway in HaCaT cells
- Nrf2 activation by curcumin improves exercise performance of mice with chronic heart failure
- The role of Nrf2 in primary human CD4 T cell activation and differentiation
- Nrf2 activator corosolic acid meliorates alloxan induced diabetic nephropathy in mice
- Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway
- … inhibits TNF-α-induced angiogenesis and ROS generation through suppression of MMP-9/NF-κB signaling and activation of Nrf2-mediated antioxidant genes …
- Plumbagin ameliorates memory dysfunction in streptozotocin induced Alzheimer’s disease via activation of Nrf2/ARE pathway and inhibition of β-secretase
- Fusaric acid induces NRF2 as a cytoprotective response to prevent NLRP3 activation in the liver derived HepG2 cell line
- Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington’s disease: Activation of the Nrf2 pathway through lysophosphatidic acid …
- 1, 4-Naphthoquinone, a pro-oxidant, ameliorated radiation induced gastro-intestinal injury through perturbation of cellular redox and activation of Nrf2 pathway
- HO-1/EBP interaction alleviates cholesterol-induced hypoxia through the activation of the AKT and Nrf2/mTOR pathways and inhibition of carbohydrate …
- Epicatechin isolated from Tripterygium wilfordii extract reduces tau-GFP-induced neurotoxicity in zebrafish embryo through the activation of Nrf2
- Protective effects of tyrosol against LPS-induced acute lung injury via inhibiting NF-κB and AP-1 activation and activating the HO-1/Nrf2 pathways
- Saeng-Kankunbi-Tang (生肝健脾汤) protects liver against oxidative damage through activation of ERK/Nrf2 pathway
- Possible involvement of transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2) in the protective effect of caffeic acid on paraquat-induced …
- In vitro biotransformation of the Nrf2 activator bardoxolone: formation of an epoxide metabolite that undergoes two novel glutathione-mediated metabolic pathways …
- Research progress of small molecule activators in Keapl-Nrf2-ARE signaling pathway
- Utilization of the Ability to Induce Activation of the Nuclear Factor (Erythroid‐derived 2)‐like Factor 2 (Nrf2) to Assess Potential Cancer Chemopreventive Activity of …
- … revitalizes Amyloid beta (25–35)-induced and organophosphate pesticides pestered neurotoxicity in SH-SY5Y and IMR-32 cells via activation of APE1 and Nrf2
- S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2
- 17-β estradiol exerts anti-inflammatory effects through activation of Nrf2 in mouse embryonic fibroblasts
- Protective effect of Nrf2 activation by curcumin against lead-induced toxicity and apoptosis in SH-SY5Y cells
- Activation of the molecular and functional effects of Nrf2 against chronic iron oxide nanorod overload-induced cardiotoxicity
- Protective effect of Rumenic acid rich cow’s milk against colitis is associated with the activation of Nrf2 pathway in a murine model
- Docosahexaenoic acid induces expression of heme oxygenase-1 and NAD (P) H: quinone oxidoreductase through activation of Nrf2 in human mammary epithelial …
- Activation of Nrf2 translation by a Keap1 independent mechanism
- Neuroligin-3 protects retinal cells from H2O2-induced cell death via activation of Nrf2 signaling
- Thymus vulgaris alleviates UVB irradiation induced skin damage via inhibition of MAPK/AP‐1 and activation of Nrf2‐ARE antioxidant system
- … cells (HTMCs) via the phosphatidylinositol 3-kinase (PI3K)/serine/threonine kinase (Akt)-mediated factor-E2-related factor 2 (Nrf2) signaling activation
- Cinnamaldehyde attenuates high glucose-induced oxidative stress and endothelial dysfunction as an Nrf2 activator
- Phytochemical combinations modulate the activation of Nrf2 and expression of SOD in pancreatic cancer cells more efficiently than single plant components
- Nrf2-Mediated System xc− Activation in Astroglial Cells Is Involved in HIV-1 Tat-Induced Neurotoxicity
- IL-17 enhances oxidative stress in hepatocytes through Nrf2/keap1 signal pathway activation
- Response to comment on “NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis”
- Ligustrazine nanoparticles nano spray’s activation on Nrf2/ARE pathway in oxidative stress injury in rats with postoperative abdominal adhesion
- Nrf2 activation mediates tumor-specific hepatic stellate cells-induced DIgR2 expression in dendritic cells
- Activation of imidazoline I1 receptor by moxonidine regulates the progression of liver fibrosis in the Nrf2-dependent pathway
- Activation of the nuclear erythroid 2-related factor 2 antioxidant responsive element (Nrf2-ARE) signaling pathway alleviates acute graft-versus-host disease …
- Inhibition of early biochemical defects in prodromal Huntington’s disease by simultaneous activation of Nrf2 and elevation of multiple micronutrients
- Ethyl 2, 4-dicarboethoxy pantothenate, a derivative of pantothenic acid, prevents cellular damage initiated by environmental pollutants through Nrf2 activation
- Hepatoprotective effect of 7-hydroxycoumarin against methyl glyoxal toxicity via activation of Nrf2
- Chronic arsenic-induced metabolic syndrome: A role for prolonged Nrf2 activation and mitochondrial metabolism
- Protective function of pyridoxamine on retinal photoreceptor cells via activation of the p‑Erk1/2/Nrf2/Trx/ASK1 signalling pathway in diabetic mice
- 4-Nitrophenol induces activation of Nrf2 antioxidant pathway and apoptosis of the germ cells in rat testes
- Schisandra chinensis Stem Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity via Activation of the Nrf2 Pathway and Inhibition of the MAPKs and NF …
- Activation of NRF2 signaling in breast cancer stem cell-enriched population
- Protective effects of ursolic acid on osteoblastic differentiation via activation of IER3/Nrf2
- The Immune Response to Influenza is Suppressed by the Synthetic Food Additive and Nrf2 Activator, tert‐butylhydroquinone (tBHQ)
- Over-activation of the Nrf2-antioxidant response element pathway in hepatocytes decreases hepatic ischemia reperfusion injury in mice
- Hepatoprotective effect of Paeoniae radix via Nrf2 activation
- Mycosporine-like amino acid activation of the Keap1-Nrf2 pathway
- Thai herbal antipyretic 22 formula (APF22) inhibits UVA‐mediated melanogenesis through activation of Nrf2‐regulated antioxidant defense
- MiR‐21‐Mediated Suppression of Smad7 Induces TGF β1 and Can Be Inhibited by Activation of Nrf2 in Alcohol‐Treated Lung Fibroblasts
- … from Rhizoma Panacis Majoris attenuate myocardial ischemia/reperfusion injury via the activation of the Sirt1/Foxo1/Pgc-1α and Nrf2/antioxidant defense pathways in …
- Evaluation of a new pharmacologic strategy for Nrf2 activation for retinal ischemia-reperfusion injury
- Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene …
- Effects of Schisandrae chinensis fructus induced CYPs and Nrf2 activation on acute liver injury induced by acetaminophen
- … analysis in peripheral blood cells of patients with hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC): identification of NRF2 pathway activation
- Publisher Correction: Valproic Acid Sensitizes Hepatocellular Carcinoma Cells to Proton Therapy by Suppressing Nrf2 Activation
- Involvement of Oxidative Stress, Inflammation, and Glutamate in Ototoxici-ty, and their Attenuation by Simultaneous Activation of Nrf2 and Elevation of …
- Activation of Nrf2 Target Genes by Aged Garlic Extract in THP‐1 Macrophages: Regulation by Glutathione Depletion
- Roasted coffee induction of aldo-keto reductase 1C3 expression in LNCaP human prostate cancer cells is associated with Nrf2 activation
- A new approach for skin-derived precursors to ameliorate skin photodamage through activation of nrf2 signaling pathway
- Nrf2 activation but not vitamin C treatment promotes proteostatic maintenance during an oxidative challenge
- Identification and Structural Analysis of New Nrf2 Activators by Mechanism‐Based Chemical Transformation of 15‐Deoxy‐Δ12, 14‐PGJ2
- The Nrf2 activators tBHQ and CDDO-Im have both Nrf2-dependent and–independent effects on human Jurkat T cell activation, as determined by CRISPR-Cas9 gene …
- FO006 THE NRF2 ACTIVATOR BARDOXOLONE METHYL INHIBITS CYST FORMATION, REDUCES INFLAMMATION, AND IMPROVES MITOCHONDRIAL …
- Nrf2 activation and fetal hemoglobin induction in sickle cell disease
- A pan-ErbB family inhibitor, AF8c, promotes apoptosis by DR5/Nrf2 activation via ROS in colorectal cancer cells
- Simultaneous Activation of Nrf2 and Elevation of Dietary and Endogenous Antioxidants for Prevention and Improved Management of Parkinson’s Disease
- Abstract TP573: Nrf2 Activation With Sulforaphane Reduces Post-Stroke Cognitive Impairment in Mice
- Dual Activation of NRF2 in Multiple Myeloma and Bone Marrow Mesenchymal Stromal Cells Regulates Chemotherapy Resistance
- Single-cell RNA-sequencing of Herpes simplex virus 1-infected cells identifies NRF2 activation as an antiviral program
- Zinc, sulphate preconditioning alleviates rat myocardial hypoxia reoxygenation injury in vitro: activation of the Nrf2/ARE signaling pathway
- Genetic activation of NRF2 By KEAP1 inhibition induces fetal hemoglobin expression and triggers anti-oxidant stress response in erythroid cells
- Luteolin 5-O-glucoside from Korean milk thistle, Cirsium maackii, exhibits anti-inflammatory activity via activation of the Nrf2/HO-1 pathway
- NRF2 activation via PI3K/AKT/mTOR/RPS6 causes resistance to anti-HER2 agents among HER2 amplified gastric cancer
- R970, A Selective Activator of Nrf2, is Efficacious in a Murine Model of Multiple Sclerosis
- Activation of nuclear factor erythroid 2-related (Nrf2) system as a novel therapeutic approach in COPD
- Nrf2 But Not Autophagy Activation Is Associated with Resistance to EGFR Inhibitor‐Induced Lung Tumor Cell Apoptosis
- … B, a nutmeg lignan, in nonalcoholic fatty liver disease: Anti‐lipogenic and hepatocyte‐protective effects through AMP‐activated protein kinase and Nrf2 activation
- Application of Nrf2 activators in the treatment of Alzheimer′ s disease
- 213 Nrf2 activation improves both hyperpolarization-and NO-mediated responses in penile vasculature from patients with erectile dysfunction
- Lactucopicrin suppresses oxidative stress initiated by scopolamine‐induced neurotoxicity through activation of NRF2 pathway
- Effect of PI3K-Mediated Nrf2 Phosphorylated Activation in Quercetin in Inhibiting Clivorine-Induced Hepatotoxicity
- Correction to: Sulforaphane protects granulosa cells against oxidative stress via activation of NRF2-ARE pathway
- The Protective Effect of Nrf2 Activation in Cardiovascular Disease
- Protective effects of sulforaphane on STZ‐induced diabetic retinopathy via activation of Nrf2/HO‐1 antioxidant pathway and inhibition of NADPH oxidase
- Quantifying synergy for hormetic compounds using the dose-equivalence/zero-interaction (DE/ZI) method: Nrf2/antioxidant response element pathway activation
- … exert anti-photoaging effects on primary dermal fibroblasts and mouse skin exposed to UVA in association with activation of Nrf2-mediated antioxidant response
- Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling.
- A ROLE FOR NRF2 ACTIVATION IN DELAYED AGING: EVIDENCE FROM BENCH TO BEDSIDE
- Inhibition of ROS-Induced Nrf2 antioxidant pathway activation may explain synergy between venetoclax and hypomethylating agents against acute myeloid …
- MP369 D PINITOL ALLEVIATES CYCLOSPORINE-INDUCED RENAL FIBROSIS VIA THE ACTIVATION OF SIRT1 AND NRF2 ANTIOXIDANT PATHWAYS
- Nrf2 activators as therapy for acute radiation dermatitis
- Characterization of the Molecular Mechanisms of Xenobiotic-Induced NRF2 Activation for Disease Prevention and Intervention
- Effect of Treatment with a NRF2 Activator on In Vivo Proteostasis in Mice
- Beneficial Effects of Nrf2 Activation on Vascular Function and Detrimental Effects of Nrf2 Activation on Renal Function in Dahl Salt‐Sensitive Rats
- A novel Nrf2 activator RS9 protects ARPE-19 cells from oxidative stress induced by NaIO3 via autophagic pathway
- Regular intake of high-fat diet exacerbates oxidative stress-mediated DNA hypermethylation and activation of Nrf2-Keap1 signaling in UVB-induced skin tumors in …
- The effects of Nrf2 activator in a rodent model of anterior ischemic optic neuropathy (rAION)
- Evaluation of a novel phytochemical Nrf2 activator on cytoprotective gene expression and proteostasis in vivo
- GW27-e1152 Activation of cannabinoid receptor II-CB2 ameliorates cardiac fibrosis after myocardial infarction via Nrf2-mediated inhibition of TGFβ-1/Smad3 pathway
- Nrf2 activation skews murine and human CD4 T cell differentiation towards a Th2 phenotype
- Inflammatory stress induces a biphasic Nrf2 activation in neuronal cells
- Restoration of Microglial Transporter Expression by Nrf2 Activation
- Rescuing Alzheimer’s Disease-Related Memory Impairment Through Nrf2 Activation
- The Role Of Aldo-Keto Reductases And Nrf2 Signaling In The Metabolic Activation Of Nitrated Polycyclic Aromatic Hydrocarbons
- The Phytochemistry of Selected Ancistrocladus and Monsonia Species and their Anti-Pancreatic Cancer and Nrf2 Activator Properties
- The Nrf2 activator methyl bardoxolone exacerbates mitochondrial dysfunction in palmitate-treated breast cancer cells
- Interactions between Nrf2 Activation and Glutathione in the Maintenance of Redox Homeostasis
- NRF2 activator RS9 protects corneal epithelium from cell damage in dry eye models
- Activation of Nrf2 by Lipid Peroxidation Products
- A therapeutic strategy for psoriasis: STAT3 and NF-κB inhibition by tussilagonone as an Nrf2 activator in keratinocytes
- Induction of Endogenous Nrf2 Activation in the Retina Partially Protects from Oxidative Stress and Inflammation
- The Nrf2 activator, tBHQ, inhibits IL-2 production by human T cells in a largely Nrf2-independent manner
- GW29-e0001 Cinnameldehyde Attenuated Endothelial Dysfunction through Nrf2 Activation as a TRPA1 Agonist
- A0625 Cinnameldehyde Attenuated Endothelial Dysfunction through Nrf2 Activation as a TRPA1 Agonist
- Nrf2 Activation Rescues Dendritic Pathology in hPSC‐Derived And Primary Neuron Based Models of Parkinson’s Disease
- Nature‐inspired Nrf2 activators in retinal pigment epithelial cells: a source for therapeutics in age‐related macular degeneration
- Dengue virus infection causes Nrf2 activation to induce CLEC5A-facilitated TNF-α production in mononuclear phagocytes
- Novel regulators of Nrf2 activation relevant for drug-induced liver injury identified by a RNAi-based high throughput microscopy screening
- Activated SIRT1 and SIRT6 by Nrf2 Activator Attenuated Cisplatin-Induced Acute Nephrotoxicity in Mice
- Effect of NRF2 Activation on Endothelial Function, Microvessel Density, and Gene Expression in Rats fed High Salt Diet
- Targeting the Nrf2/NLRP3-Inflammasome Axis with Nrf2 Activators Lessens Macrophage Oxidative Stress and Cytokine Production, and Improves End Points …
- Involvement of lipid rafts on Nrf2 activation induced by quercetin
- BENEFICAL EFFECTS OF BARDOXOLONE METHYL, A NRF2 ACTIVATOR, ON ACETAMINOPHEN-INDUCED ACUTE NEPHROTOXICITY IN RATS
- Identification and Structural Analysis of New Nrf2 Activators by Mechanism-Based Chemical Transformation of 15-Deoxy-Δ12, 14-PGJ2
- Sulforaphane Induces Colorectal Cancer Cell Proliferation through Nrf2 Activation in a p53‐Dependent Manner
- Nrf2 Activation Attenuates Hemolysis but Promotes Pulmonary Vascular Dysfunction in Sickle Mice
- Diallyl Trisulfide Prospectively Retrieves Arsenic Induced Lung Oxidative Stress, Inflammation Through the Activation of Nrf2/HO-1 Signaling
- The Role of Nrf2 in the Activation of Primary CD4 T Cells from Mice and Humans
- … : Ischemic Preconditioning Improves Long-Term Outcomes and Preserves Blood-Brain Barrier After Ischemic Stroke via Oxidative Signaling and Nrf2 Activation
- Protandim® Treatment Causes Reversible Nuclear Translocation of Nrf2 and Activation of the Antioxidant Response Element
- 2′-O-Galloylhyperin Isolated From Pyrola incarnata Fisch. Attenuates LPS-Induced Inflammatory Response by Activation of SIRT1/Nrf2 and Inhibition of the …
- Activation of Nrf2 by 18α-GA affects proliferation of adult neural stem cells
- Abstract B16: Activation of NRF2 and adaptive resistance to chemotherapy
- The Nrf2 activator dimethyl fumarate inhibits acute graft-versus-host disease with retention of graft-versus-tumor effects
- Muscle contractile activity‐mediated regulation of antioxidant enzymes in oxidative muscle requires p62/SQSTM1 phosphorylation‐induced Nrf2 activation
- Spatio-temporal analysis of the Nrf2 activation in transgenic reporter mouse fed with high dosage of saturated or unsaturated fatty acids using in vivo bioluminescent …
- FOXQ1 promotes proliferation and metastasis of epithelial ovarian cancer via activation of SIRT1/NRF2 signaling pathway
- The Neuroprotective Effect of a Synthetic Chalcone Analog Through the Activation of Akt/Erk/Nrf2 Signaling
- Non-electrophilic activation of the Nrf2 pathway ameliorated experimental Nonalcoholic Steatohepatitis ADD YOUR LOGOS
- … to “Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation”[Redox Biol. 17 …
- … /Zero-Interaction (DE/ZI) Method for Quantifying Small Molecule Interactions: Nrf2/Antioxidant Response Element Pathway Activation by Sulforaphane and a …
- Selective Inhibition Of Hdac3 Prevents Diabetic Cardiomyopathy In Ove26 Mice Via Mir-200a-mediated Nrf2 Activation
- Fermented black radish (FBR) ameliorates hepatic lipid accumulation by transcriptional factor Nrf2 activation in HepG2 cells
- KEAP1 gene editing using CRISPR/Cas9 for therapeutic NRF2 activation in human T cells
- Correction to: A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization by Wang Y, Huang Y, Xu Y, Ruan W …
- Effects of PKC activation on expression of Nrf2 in rabbit RPE cells
- 24-hydroxycholesterol as Nrf2 activator able to enhance tau clearance for treatment of Alzheimer’s disease
- Oncogenic activation of Nrf2 by specific knockout of Nrf1α that acts as a dominant tumor repressor
- … latifolin isolated from Dalbergia odorifera attenuates hypoxia-reoxygenation injury by reactive oxygen species scavenging and Nrf2 activation in H9c2 cardiomyocyte
- … Prognosis Acute Myeloid Leukemia and Suggests a Novel Therapeutic Strategy By Combined Bromodomain Inhibition and Forced NRF2 Pathway Activation
- Corrigendum to” Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice”[Bioorg. Med. Chem. 25 (20) …
- A novel role of topical iodine in skin: Activation of the Nrf2 pathway.
- … sativus) intake provides nutritional preconditioning against myocardial ischemia-reperfusion injury in wild type and Apo-E (−/−) mice: involvement of Nrf2 activation
- Synthesis and biological activity of chalcone derivatives as potent activators of Nrf2
- Xiaochaihutang attenuates liver fibrosis in rats through activation of Nrf2 pathway
- C15 is actionable drug target for anti-arthritis via activation Nrf2 signaling
- Activation Of Nrf2 Appears To Prevent Alcohol-Mediated Induction Of TGFβ1 By Suppressing MiR-21 And Restoring Smad7 Expression
- Brg1 Protects Cardiomyocytes Against Oxidative Damage Through Activation of the Nrf2 Signaling Pathway in Acute Myocardial Infarction
- Activation of the Transcription factor Nrf2 involved in human trophoblast syncytialization (in vitro study)
- NRF2 drives glioma malignancy through transcriptional activation of an important oncogenic mechanism
- Ameliorative effect of esculetin against streptozotocin-induced experimental dementia via activation of Nrf2/HO-1 axis and suppression of NF-kappa B
- Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling Ravikanth Velagapudi1, 4, Asit Kumar2, 5, Harsharan S Bhatia2, 3 …
- Nrf2 knockout: The effect on neurological dysfunction and the activation of glial cells of mice after brain injury
- Cardiac-Specific Constitutive Activation of Nrf2 Induces a Stable Reductive State in Mice
- RPS6 through the activation of NRF2 causes resistance to antiHER2 drugs in HER2 amplified gastric cancer (GC) models
- Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and P53 defense …
- Dr. Jekyll and Mr. Hyde: Reactive Oxygen Species Play Opposing Roles in Electrophile-Mediated Nrf2/Antioxidant Response Element Activation
- Activation of Nrf2 suppresses inflammation and semaphorin 6A signaling in oxygen-induced retinopathy
- Cardiac-specific Constitutive Activation of Nrf2 Induces Reductive Stress and Pathological Cardiac Remodeling
- THU0053 Selective activation of an AMPK-CREB-NRF2-dependent pathway by celecoxib induces vasculoprotective genes and mitigates against cardiovascular risk
- Corrigendum to” JWA antagonizes paraquat-induced neurotoxicity via activation of Nrf2″[Toxicol. Lett. 277 (August)(2017) 32-40]
- … Article Dietary Lycium barbarum Polysaccharide Induces Nrf2/ARE Pathway and Ameliorates Insulin Resistance Induced by High-Fat via Activation of PI3K/AKT …
- Activation of Nrf2 attenuates pulmonary vascular remodeling via inhibiting endothelial-to-mesenchymal transition
- Retraction: Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2. A NOVEL MECHANISM IN NRF2 ACTIVATION.
- Corrigendum: Investigation of Nrf2, AhR and ATF4 activation in toxicogenomic databases
- Pharmacological Activation of Nrf2 by Sesamol Stimulates Ucp1 Induction in Adipocytes and Increases Energy Expenditure in Mice
- Downregulated Microrna-27b Attenuates Lipopolysaccharide-Induced Acute Lung Injury Via Activation of Nrf2 and Inhibition of NF-κB Signaling Pathways
- Correction to: Nrf2-Mediated System xc − Activation in Astroglial Cells Is Involved in HIV-1 Tat-Induced Neurotoxicity
- Role of ROS in emulsified isoflurane postconditioning-induced activation of Nrf2/ARE signaling pathway in rat cardiomyocytes
- Activation of the proteasome machinery by NRF2/mutant p53 axis and its therapeutic implications for triple negative breast cancer
- Glutathione (GSH) distribution by quantitative MALDI imaging in reconstructed human skin upon activation of GSH biosynthesis by Nrf2 pathway activator
- Role of ROS in emulsified isoflurane postconditioning-induced promotion of Nrf2∕ ARE signaling pathway activation in rats with myocardial injury
- Retinoid X Receptor´ s activation modulates a crosstalk between NrF2 and NFkB pathway in retinal pigment epithelium cells upon H2O2 treatment
- A defect in the Nrf2/HO-1 pathway and Nox2 activation results in regulatory T cell mitochondrial dysfunction in alcohol related cirrhosis
- A28 EXOSOMES AND MICRORNA: Activation Of Nrf2 Appears To Prevent Alcohol-Mediated Induction Of Tgfβ1 By Suppressing Mir-21 And Restoring Smad7 …
- Rodgersia podophylla Leaves Suppress Inflammatory mediators through activation of Nrf2/HO-1 signaling, and inhibition of LPS-induced NF-κB and MAPKs signaling …
- Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2. A NOVEL MECHANISM IN NRF2 ACTIVATION.
- Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2. A novel mechanism in Nrf2 activation.
- Tsg101 Protects the Heart Against Ischemia/Reperfusion Injury Through Aggregation of P62 and Activation of NRF2 Signaling
- Activated microglia enhance astroglial neuroprotective pentose-phosphate pathway through the activation of the Keap1/Nrf2 system by nitric oxide
- Activation of NF-Kappa B-p62-NRF2 Signaling Supports the Survival of CLL Cells That Express High Levels of ROR1
- … sulfide ameliorates learning memory impairment in APP/PS1 transgenic mice: A novel mechanism mediated by the activation of Nrf2″[Pharmacol. Biochem. Behav …
- 5-aminolevulinic acid exerts renoprotective effect via Nrf2 activation in murine rhabdomyolysis-induced acute kidney injury
- … Effect of Sageretia theezans against the Production of Pro-Inflammatory Mediators through the Inhibition of NF-κB and MAPK, and Activation of Nrf2/HO-1 Signaling …
- … -induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2–Cul3–Rbx1 complex to allow normal Nrf2 activation and …
- EF Derived from Human Placental Mesenchymal Stem Cells Improves Premature Ovarian Insufficiency Via NRF2/HO-1 Activation
- Artemether Activation of AMPK/GSK3β (ser9)/Nrf2 Signaling Confers Neuroprotection towards β-Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse Model
- Stromal Cell-derived Factor-1 Prevents From Diabetic Cardiomyopathy via Cxcr7/ampk-mediated Nrf2 Activation in Type 2 Diabetic Mice
- Intracellular redox status determines self-renewal activity of breast cancer stem-like cells through activation of Nrf2-mediated FoxO3a-Bmi-1 signaling
- … /Food Microbiology: Cytoprotective Effect of Makgeolli Lees on Paraquat Induced Oxidative Stress in A549 Cells via Activation of NRF2 and Antioxidant Genes
- Suppression of microRNA-128 attenuates high glucose-induced podocyte apoptosis through activation of Nrf2-ARE signaling pathway
- Citrus polymethoxyflavones (PMFs) inhibit 12‐O‐tetradecanoylphorbol 13‐acetate (TPA) induced mouse skin JB6 P+ cell transformation through the activation of Nrf2 …
- : Anthraquinone and naphthopyrone glycosides from Cassia obtusifolia seeds exhibit hepatoprotective activity via activation of the Nrf2/HO-1 and modulation of JNK …
- Involvement of Nrf2-mediated heme oxygenase-1 expression in anti-inflammatory action of chitooligosaccharides through MAPK activation in murine macrophages
- Role of Protein Kinases on Activation of Nrf2/Keap1/ARE Signaling Pathway by Sulforaphane and Licochalcone A in HCT116 Human Colon Cancer Cells
- Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by A𝛽42 through Nrf2-Related Inflammatory …
- … serratifolium suppresses RANKL-induced osteoclast differentiation and oxidative stress through inhibition of NF-κB and activation of the Nrf2/HO-1 signaling pathway
- … Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient …
- MP45-05 ACTIVATION OF NRF2 IMPROVES ENDOTHELIAL FUNCTION IN CORPUS CAVERNOSUM FROM AGED RATS AND IN CORPUS CAVERNOSUM AND …
- … ) ATTENUATES CPP-INDUCED CALCIFICATION OF VASCULAR SMOOTH MUSCLE CELLS VIA ACTIVATION OF THE KEAP1 NRF2 NQO1 SIGNALING PATHWAY
- Angiotensin-(1-7) attenuates endothelial cell senescence via klotho and Nrf2 activation
- Thioredoxin related protein of 14 kDa (TRP14, TXNDC17) represses Nrf2 and NFκB activities and augments HIF activation
- Protective effects of Zhen-Gan Xi-Feng decoction-containing serum on 6-OHDA-induced oxidative stress in PC12 cells through Nrf2-ARE pathway activation
- Epigallocatechin-3-gallate as an activator of Nrf2/ARE signaling pathway: a review
- 60 Quercetin protects bovine pre-implantation embryos against oxidative stress via activation of Nrf2 signaling pathway
- 516-P: Preventive Effect of Sulforaphane on Type 2 Diabetes-Induced Diabetic Nephropathy via AMPK-Mediated Activation of Glucose/Lipid Metabolism and Nrf2 …
- 372-P: Activation of the Nrf2 Pathway Provides Protection against Hypoglycaemia-Induced Cognitive Impairment in a Rodent Model of Type 1 Diabetes
- 613-P: Preventive Effect of Sulforaphane on Type 2 Diabetes-Induced Diabetic Cardiomyopathy via AMPK-Mediated Activation of Glucose/Lipid Metabolism and Nrf2 …
- Abstract P344: Nuclear Factor E2-related Factor 2 (nrf2) Causes Early Microvascular Endothelial Dysfunction and Increased Adma by Activation of the Cox2/tp …
- … (Chinese mystery snail) alcalase hydrolysate attenuates inflammatory responses in LPS-stimulated Raw 264.7 macrophages via the activation of Nrf2/HO-1 signaling
- … CHANNEL BLOCKER ATTENUATES UNILATERAL URETERAL OBSTRUCTION-INDUCED RENAL INTERSTITIAL FIBROSIS VIA ACTIVATION OF THE NRF2 …
- Thai herbal antipyretic 22 formula inhibits melanogenesis through activation of NRF2-regulated antioxidant defense in UVA-irradiated B16 melanoma cells
- … toS-Allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of …
- … 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-related kinase (ERK)/NRF2 signaling pathway and …
- … of hepatitis B surface antigen and mutated alpha-1 antitrypsin promotes the development of liver disease via autophagy overload and activation of p62-mTOR-Nrf2 …
- Hesperetin induces glyoxalase 1 enhancement in SH-SY5Y cells cultured with high glucose via Nrf2/ARE activation.
- Paeonol attenuates high glucose-induced expression of FN and ICAM-1 by promoting the activation of Nrf2/ARE pathway via upregulation of Sirt1 in GMCs
- An update of Nrf2 activators and inhibitors in cancer prevention/promotion
- The hormetic dose-response mechanism: Nrf2 activation
- The Nrf2 activator (DMF) and covid-19: is there a possible role?
- Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19
- Can activation of NRF2 be a strategy against COVID-19?
- COPD lung studies of Nrf2 expression and the effects of Nrf2 activators
- Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage
- NRF2 activation promotes aggressive lung cancer and associates with poor clinical outcomes
- Nrf2 activation in chronic kidney disease: promises and pitfalls
- The pivotal role of Nrf2 activators in adipocyte biology
- Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction
- Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson’s disease animal model
- Recent progress in the development of small molecule Nrf2 activators: a patent review (2017-present)
- Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis
- Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
- Systems biology reveals anatabine to be an NRF2 activator
- Role of microgliosis, oxidative stress and associated neuroinflammation in the pathogenesis of Parkinson’s disease: The therapeutic role of Nrf2 activators
- NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism
- Nrf2 activation and its coordination with the protective defense systems in response to electrophilic stress
- Combination of autophagy and NFE2L2/NRF2 activation as a treatment approach for neuropathic pain
- A review on herbal Nrf2 activators with preclinical evidence in cardiovascular diseases
- Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy
- Genetic or pharmacologic Nrf2 activation increases proteinuria in chronic kidney disease in mice
- Microenvironmental activation of Nrf2 restricts the progression of Nrf2-activated malignant tumors
- NRF2 activation and downstream effects: focus on Parkinson’s disease and brain angiotensin
- NRF2 and the ambiguous consequences of its activation during initiation and the subsequent stages of tumourigenesis
- Impacts of NRF2 activation in non–small‐cell lung cancer cell lines on extracellular metabolites
- The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling
- Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose
- … mechanisms underlying hepatocellular carcinoma induction by aberrant NRF2 activation-mediated transcription networks: interaction of NRF2-KEAP1 controls the …
- Dietary phenolic-type Nrf2-activators: implications in the control of toxin-induced hepatic disorders
- Potential role of Nrf2 activators with dual antiviral and anti-inflammatory properties in the management of viral pneumonia
- Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis
- Ammonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells
- Nrf2 activators as dietary phytochemicals against oxidative stress, inflammation, and mitochondrial dysfunction in autism spectrum disorders: a systematic …
- Role of NRF2 and Sirtuin activators in COVID-19
- EV71 virus reduces Nrf2 activation to promote production of reactive oxygen species in infected cells
- Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators
- Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain
- Bruceine D elevates Nrf2 activation to restrain Parkinson’s disease in mice through suppressing oxidative stress and inflammatory response
- Systemic activation of Nrf2 pathway in Parkinson’s disease
- Activation of Nrf2 by natural bioactive compounds: a promising approach for stroke?
- … DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt (Ser473)/GSK3β (Ser9)-mediated Nrf2 activation
- Nrf2 activator PB125® as a carnosic acid-based therapeutic agent against respiratory viral diseases, including COVID-19
- Pharmacological activation of Nrf2 promotes wound healing
- Nrf2 activation attenuates acrylamide-induced neuropathy in mice
- p62 bodies: phase separation, NRF2 activation, and selective autophagic degradation
- … of redox processes in biological systems with the participation of the Keap1/Nrf2/ARE signaling pathway, biogenic selenium nanoparticles as Nrf2 activators
- Nrf2 activation putatively mediates clinical benefits of low-dose radiotherapy in COVID-19 pneumonia and acute respiratory distress syndrome (ARDS): Novel …
- SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer
- Development and optimization of halogenated vinyl sulfones as Nrf2 activators for the treatment of Parkinson’s disease
- Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators
- Carbon monoxide releasing molecule-A1 improves nonalcoholic steatohepatitis via Nrf2 activation mediated improvement in oxidative stress and …
- Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation
- Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells
- Novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy
- Phloretin suppresses neuroinflammation by autophagy-mediated Nrf2 activation in macrophages
- AMPK/p38/Nrf2 activation as a protective feedback to restrain oxidative stress and inflammation in microglia stimulated with sodium fluoride
- Dimethyl Fumarate Triggers the Antioxidant Defense System in Human Retinal Endothelial Cells through Nrf2 Activation
- Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition
- Therapeutic effects of CO-releaser/Nrf2 activator hybrids (HYCOs) in the treatment of skin wound, psoriasis and multiple sclerosis
- Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation
- Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular …
- Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease
- Activation of transcription factor Nrf2 to counteract mitochondrial dysfunction in Parkinson’s disease
- NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis
- The genotoxic potential of mixed nitrosamines in drinking water involves oxidative stress and Nrf2 activation
- Beyond direct Nrf2 activation; reinvestigating 1, 2, 4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy
- β-Arrestin1 reduces oxidative stress via Nrf2 activation in the rostral ventrolateral medulla in hypertension
- Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism
- Role of Nrf2 and its activators in cardiocerebral vascular disease
- … -target directed ligands strategy for the treatment of Alzheimer’s disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 activator
- Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress
- Natural Nrf2 activators from juices, wines, coffee, and cocoa
- Carveol a naturally-derived potent and emerging Nrf2 activator protects against acetaminophen-induced hepatotoxicity
- Nrf2 activation is involved in osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch
- Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans
- Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage
- Pharmacological activation of Nrf2 enhances functional liver regeneration
- Nrf2 activation: involvement in central nervous system traumatic injuries. a promising therapeutic target of natural compounds
- Activation of the Nrf2 pathway as a therapeutic strategy for ALS treatment
- Discovery of eicosapentaenoic acid esters of hydroxy fatty acids as potent Nrf2 activators
- Dietary prenylated flavonoid xanthohumol alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation
- Biotinylation of an acetylenic tricyclic bis (cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1
- Nrf2 activation sensitizes K-Ras mutant pancreatic cancer cells to glutaminase inhibition
- Proanthocyanidins-mediated Nrf2 activation ameliorates glucocorticoid-induced oxidative stress and mitochondrial dysfunction in osteoblasts
- Nrf2 activation protects auditory hair cells from cisplatin-induced ototoxicity independent on mitochondrial ROS production
- Mutational activation of the NRF2 pathway upregulates kynureninase resulting in tumor immunosuppression and poor outcome in lung adenocarcinoma
- A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis
- Identification and evaluation of a napyradiomycin as a potent Nrf2 activator: Anti-oxidative and anti-inflammatory activities
- NRF2 activation confers resistance to eIF4A inhibitors in cancer therapy
- Ferulic acid influences Nrf2 activation to restore testicular tissue from cadmium‐induced oxidative challenge, inflammation, and apoptosis in rats
- Coniferaldehyde attenuates Alzheimer’s pathology via activation of Nrf2 and its targets
- Harnessing the cardiovascular benefits of exercise: Are Nrf2 activators useful?
- NRF2-dependent bioactivation of mitomycin C as a novel strategy to target KEAP1-NRF2 pathway activation in human cancer
- Chrysin rescues rat myocardium from ischemia-reperfusion injury via PPAR-γ/Nrf2 activation
- Plant-derived polyphenols as Nrf2 activators to counteract oxidative stress and intestinal toxicity induced by deoxynivalenol in swine: An emerging research …
- Acute lung inflammation induced by zinc oxide nanoparticles: Evolution and intervention via NRF2 activator
- Salidroside protects against osteoporosis in ovariectomized rats by inhibiting oxidative stress and promoting osteogenesis via Nrf2 activation
- Flavonoids activation of the transcription factor Nrf2 as a hypothesis approach for the prevention and modulation of SARS-CoV-2 infection severity
- Iron-mediated epigenetic activation of NRF2 targets
- Advances of natural activators for Nrf2 signaling pathway on cholestatic liver injury protection: a review
- Chlorogenic acid improves diabetic retinopathy by alleviating blood‐retinal‐barrier dysfunction via inducing Nrf2 activation
- A novel uterine leiomyoma subtype exhibits NRF2 activation and mutations in genes associated with neddylation of the Cullin 3-RING E3 ligase
- HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells
- The protective effects of flavonoids in cataract formation through the activation of Nrf2 and the inhibition of MMP-9
- The novel Nrf2 activator omaveloxolone regulates microglia phenotype and ameliorates secondary brain injury after intracerebral hemorrhage in mice
- The role of organosulfur compounds as Nrf2 activators and their antioxidant effects
- Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents
- Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease
- A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model
- NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington’s disease mouse model
- Nrf2 activation contributes to hepatic tumor-augmenting effects of developmental arsenic exposure
- Activation of Nrf2 signaling pathway by natural and synthetic chalcones: A therapeutic road map for oxidative stress
- Sulforaphane-mediated Nrf2 activation prevents radiation-induced skin injury through inhibiting the oxidative-stress-activated DNA damage and NLRP3 …
- Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes
- Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs
- ROS-Nrf2 pathway mediates the development of TGF-β1-induced epithelial-mesenchymal transition through the activation of Notch signaling
- Nrf2 Activation Attenuates Chronic Constriction Injury-Induced Neuropathic Pain via Induction of PGC-1α-Mediated Mitochondrial Biogenesis in the Spinal …
- The effects of two Nrf2 activators, bardoxolone methyl and omaveloxolone, on retinal ganglion cell survival during ischemic optic neuropathy
- NRF2 preserves genomic integrity by facilitating ATR activation and G2 cell cycle arrest
- Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance
- Antioxidative effects of chrysoeriol via activation of the Nrf2 signaling pathway and modulation of mitochondrial function
- Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation
- Dehydroepiandrosterone alleviates intestinal inflammatory damage via GPR30-mediated Nrf2 activation and NLRP3 inflammasome inhibition in colitis mice
- Activation of Nrf2 to Optimise Immune Responses to Intracerebral Haemorrhage
- … of Pengze crucian carp concurrent with modulating the antioxidant defense response and exerting beneficial impacts on inflammatory response via Nrf2 activation
- Nrf2 Activation and NF-Kb & caspase/bax signaling inhibition by sodium butyrate alleviates LPS-induced cell injury in bovine mammary epithelial cells
- Miconazole contributes to NRF2 activation by noncanonical P62-KEAP1 pathway in bladder cancer cells
- Persistent activation of Nrf2 promotes a vicious cycle of oxidative stress and autophagy inhibition in cadmium-induced kidney injury
- Moderate Nrf2 activation by genetic disruption of Keap1 has sex-specific effects on bone mass in mice
- The novel Nrf2 activator CDDO‐EA attenuates cerebral ischemic injury by promoting microglia/macrophage polarization toward M2 phenotype in mice
- Activation of Nrf2 in fibroblasts promotes a skin aging phenotype via an Nrf2-miRNA-collagen axis
- Therapeutic effects of specialized pro-resolving lipids mediators on cardiac fibrosis via NRF2 activation
- Activation of Nrf2 signaling: A key molecular mechanism of protection against cardiovascular diseases by natural products
- Four-octyl itaconate attenuates UVB-induced melanocytes and keratinocytes apoptosis by Nrf2 activation-dependent ROS inhibition
- Resveratrol mediates its anti-cancer effects by Nrf2 signaling pathway activation
- Lycium barbarum polysaccharide protects rats and cardiomyocytes against ischemia/reperfusion injury via Nrf2 activation through autophagy inhibition
- Urolithin A protects human dermal fibroblasts from UVA-induced photoaging through NRF2 activation and mitophagy
- Effects of the phytochemical combination PB123 on Nrf2 Activation, gene expression, and the cholesterol pathway in HepG2 cells
- Treatment with dimethyl fumarate reduces the formation and rupture of intracranial aneurysms: Role of Nrf2 activation
- Maresin1 suppresses high-glucose-induced ferroptosis in osteoblasts via Nrf2 activation in type 2 diabetic osteoporosis
- Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2
- Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure
- A nature-inspired Nrf2 activator protects retinal explants from oxidative stress and neurodegeneration
- Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2
- Dexmedetomidine alleviates inflammation in neuropathic pain by suppressing NLRP3 via Nrf2 activation
- Dietary chlorogenic acid ameliorates oxidative stress and improves endothelial function in diabetic mice via Nrf2 activation
- Allyl isothiocyanate protects acetaminophen-induced liver injury via NRF2 activation by decreasing spontaneous degradation in hepatocyte
- The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated α-MSH pathways via Nrf2 activation in …
- Beneficial effects of bardoxolone methyl, an Nrf2 activator, on crush-related acute kidney injury in rats
- A triterpenoid Nrf2 activator, RS9, promotes LC3-associated phagocytosis of photoreceptor outer segments in a p62-independent manner
- Tussilagonone ameliorates psoriatic features in keratinocytes and imiquimod-induced psoriasis-like lesions in mice via NRF2 activation
- NRF2 activation ameliorates oxidative stress and improves mitochondrial function and synaptic plasticity, and in A53T α-synuclein hippocampal neurons
- α-Cyperone Attenuates H2O2-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2
- Nrf2 signaling activation by a small molecule activator compound 16 inhibits hydrogen peroxide-induced oxidative injury and death in osteoblasts
- Nrf2 mediates hypoxia-inducible HIF1α activation in kidney tubular epithelial cells
- Activation of Nrf2 by miR-152 inhibits doxorubicin-induced cardiotoxicity via attenuation of oxidative stress, inflammation, and apoptosis
- Melatonin suppresses ferroptosis induced by high glucose via activation of the Nrf2/HO-1 signaling pathway in type 2 diabetic osteoporosis
- The Nrf2 activator MIND4‐17 protects retinal ganglion cells from high glucose‐induced oxidative injury
- P38 MAPK and Nrf2 activation mediated naked gold nanoparticle induced heme oxygenase-1 expression in rat aortic vascular smooth muscle cells
- Luteolin Alleviates AflatoxinB1-Induced Apoptosis and Oxidative Stress in the Liver of Mice through Activation of Nrf2 Signaling Pathway
- LncRNA MALAT1 facilitates inflammasome activation via epigenetic suppression of Nrf2 in Parkinson’s disease
- … ameliorates experimental diabetic kidney disease by inhibiting oxidative stress via GPER mediated p62-dependent Keap1 degradation and Nrf2 activation
- Cannabinoid-profiled agents improve cell survival via reduction of oxidative stress and inflammation, and Nrf2 activation in a toxic model combining hyperglycemia+ …
- Neuropeptide Y Promotes Human M2 Macrophage Polarization and Enhances p62/SQSTM1-Dependent Autophagy and NRF2 Activation
- Use of Physiologically Based Kinetic Modeling-Based Reverse Dosimetry to Predict In Vivo Nrf2 Activation by EGCG and Its Colonic Metabolites in Humans
- Nrf2/ARE activators improve memory in aged mice via maintaining of mitochondrial quality control of brain and the modulation of gut microbiome
- Gallic acid alleviates gouty arthritis by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling
- Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity
- NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands
- … overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation
- Mechanisms underlying unidirectional laminar shear stress-mediated Nrf2 activation in endothelial cells: Amplification of low shear stress signaling by primary …
- Molecular docking and dynamics guided approach to identify potential anti-inflammatory molecules as NRF2 activator to protect against drug-induced liver injury (DILI) …
- Nrf2 Promotes Inflammation in Early Myocardial Ischemia-Reperfusion via Recruitment and Activation of Macrophages
- Inhalable nanoparticles/microparticles of an AMPK and Nrf2 activator for targeted pulmonary drug delivery as dry powder inhalers
- … metabolic syndrome and oxidative stress in high-fat diet-induced metabolic dysfunction-associated fatty liver disease (MAFLD) in rats: Role on Nrf2 activation
- NRF2 pathway activation attenuates ageing-related renal phenotypes due to α-klotho deficiency
- Discovery of caffeoylisocitric acid as a Keap1-dependent Nrf2 activator and its effects in mesangial cells under high glucose
- Plasmodium berghei-mediated NRF2 activation in infected hepatocytes enhances parasite survival
- Chemical activators of the Nrf2 signaling pathway in nonalcoholic fatty liver disease
- SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation
- Arsenic trioxide and venetoclax synergize against AML progenitors by ROS induction and inhibition of Nrf2 activation
- Resveratrol attenuates high glucose-induced osteoblast dysfunction via AKT/GSK3β/FYN-mediated NRF2 activation
- Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus
- Activation of NRF2 by topical apocarotenoid treatment mitigates radiation-induced dermatitis
- Resveratrol inhibits MRGPRX2-mediated mast cell activation via Nrf2 pathway
- Luteolin confers cerebroprotection after subarachnoid hemorrhage by suppression of NLPR3 inflammasome activation through Nrf2-dependent pathway
- Anti-fibrotic activity of sitagliptin against concanavalin A-induced hepatic fibrosis. Role of Nrf2 activation/NF-κB inhibition
- Generation of potent Nrf2 activators via tuning the electrophilicity and steric hindrance of vinyl sulfones for neuroprotection
- Discovery of a coumarin derivative as Nrf2 activator mitigating oxidative stress and fibrosis in mesangial cells under high glucose
- Resveratrol ameliorates rheumatoid arthritis via activation of SIRT1‐Nrf2 signaling pathway
- Quercetin protects against lipopolysaccharide-induced intestinal oxidative stress in broiler chickens through activation of Nrf2 pathway
- c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation
- Effects of Launaea sarmentosa Extract on Lipopolysaccharide-Induced Inflammation via Suppression of NF-κB/MAPK Signaling and Nrf2 Activation
- Synthesis of dithiolethiones and identification of potential neuroprotective agents via activation of Nrf2-driven antioxidant enzymes
- Stabilization of Nrf2 leading to HO-1 activation protects against zinc oxide nanoparticles-induced endothelial cell death
- Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties
- Forsythoside a mitigates alzheimer’s-like pathology by inhibiting ferroptosis-mediated neuroinflammation via Nrf2/GPX4 axis activation
- Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway
- Distinct mechanisms are responsible for Nrf2-Keap1 pathway activation at different stages of rat hepatocarcinogenesis
- The principal molecular mechanisms behind the activation of Keap1/Nrf2/ARE pathway leading to neuroprotective action in Parkinson’s disease
- Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway
- Maresin1 protect against ferroptosis-induced liver injury through ROS inhibition and Nrf2/HO-1/GPX4 activation
- Crosstalk between Sirtuins and Nrf2: SIRT1 activators as emerging treatment for diabetic neuropathy
- Antioxidative and angiogenesis-promoting effects of tetrahedral framework nucleic acids in diabetic wound healing with activation of the Akt/Nrf2/HO-1 pathway
- … use of the rosemary diterpene carnosic acid for Alzheimer’s disease, Parkinson’s disease, and long-COVID through NRF2 activation to counteract the NLRP3 …
- Evaluation of oxidative damage and Nrf2 activation by combined pollution exposure in lung epithelial cells
- Activation of NRF2/FPN1 pathway attenuates myocardial ischemia–reperfusion injury in diabetic rats by regulating iron homeostasis and ferroptosis
- The effects of nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2) activation in preclinical models of peripheral neuropathic pain
- Activation of Nrf2/AREs-mediated antioxidant signalling, and suppression of profibrotic TGF-β1/Smad3 pathway: a promising therapeutic strategy for hepatic fibrosis …
- Nrf2 promotes esophageal squamous cell carcinoma (ESCC) resistance to radiotherapy through the CaMKIIα-associated activation of autophagy
- Palmatine protects against cerebral ischemia/reperfusion injury by activation of the AMPK/Nrf2 pathway
- … oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation
- Constitutive activation of Nrf2 in mice expands enterogenesis in small intestine through negative regulation of Math1
- Tadalafil alleviates cisplatin-induced reproductive toxicity through the activation of the Nrf2/HO-1 pathway and the inhibition of oxidative stress and apoptosis in male …
- Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell …
- Vitamin E protects against cadmium-induced sub-chronic liver injury associated with the inhibition of oxidative stress and activation of Nrf2 pathway
- Nrf2 activation mediates antiallodynic effect of electroacupuncture on a rat model of complex regional pain syndrome type-I through reducing local oxidative …
- Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress
- Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
- Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T …
- Nrf2 activation in the human brain after stroke due to supratentorial intracerebral haemorrhage: a case–control study
- Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation
- Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor …
- Activation of Nrf2 signaling protects hypoxia‐induced HTR‐8/SVneo cells against ferroptosis
- NRF2 Exerts Anti-Inflammatory Effects in LPS-Induced gEECs by Inhibiting the Activation of the NF-κB
- Nrf2 mutation/activation is dispensable for the development of chemically induced mouse HCC
- Irisin protects against sepsis-associated encephalopathy by suppressing ferroptosis via activation of the Nrf2/GPX4 signal axis
- The effect of dietary phytochemicals on nuclear factor erythroid 2-related factor 2 (Nrf2) activation: A systematic review of human intervention trials
- Nrf2 activation by Morinda citrifolia L.(Noni) fruit juices
- Paeonol protects melanocytes against hydrogen peroxide‐induced oxidative stress through activation of Nrf2 signaling pathway
- Transcriptional activation of antioxidant gene expression by Nrf2 protects against mitochondrial dysfunction and neuronal death associated with acute and chronic …
- Fisetin attenuates doxorubicin-induced cardiomyopathy in vivo and in vitro by inhibiting ferroptosis through SIRT1/Nrf2 signaling pathway activation
- Activation of p62-Keap1-Nrf2 pathway protects 6-hydroxydopamine-induced ferroptosis in dopaminergic cells
- Phyllostachys nigra Variety Henosis, a Domestic Bamboo Species, Protects PC12 Cells from Oxidative Stress-mediated Cell Injury through Nrf2 Activation
- β-Caryophyllene suppresses ferroptosis induced by cerebral ischemia reperfusion via activation of the NRF2/HO-1 signaling pathway in MCAO/R rats
- Activation of the NRF2 pathway in Keap1-knockdown mice attenuates progression of age-related hearing loss
- Rosmarinic acid exerts anti-inflammatory effect and relieves oxidative stress via Nrf2 activation in carbon tetrachloride-induced liver damage
- Puerarin induces Nrf2 as a cytoprotective mechanism to prevent cadmium-induced autophagy inhibition and NLRP3 inflammasome activation in AML12 hepatic cells
- Pinocembrin ameliorates post-infarct heart failure through activation of Nrf2/HO-1 signaling pathway
- Age-related mitochondrial impairment and renal injury is ameliorated by sulforaphane via activation of transcription factor NRF2
- NRF2 activation protects against valproic acid-induced disruption of neurogenesis in P19ácells
- The ameliorative effect of kaempferol against CdCl2- mediated renal damage entails activation of Nrf2 and inhibition of NF-kB
- … chronic unpredictable mild stress-induced depressive-like behaviors via restoring changes in oxidative stress and the activation of Nrf2 signaling pathway in …
- TDAG51-Deficiency Podocytes are Protected from High-Glucose-Induced Damage Through Nrf2 Activation via the AKT–GSK-3β Pathway
- Cyanidin chloride induces apoptosis by inhibiting NF-κB signaling through activation of Nrf2 in colorectal cancer cells
- Ferulic Acid Ameliorates MPP+/MPTP-Induced Oxidative Stress via ERK1/2-Dependent Nrf2 Activation: Translational Implications for Parkinson Disease Treatment
- Nrf2 activation is involved in cyclic mechanical stress-stimulated osteogenic differentiation in periodontal ligament stem cells via pi3k/akt signaling and ho1 …
- Ginsenoside Rg1 reduces oxidative stress via Nrf2 activation to regulate age-related mesenchymal stem cells fate switch between osteoblasts and adipocytes
- Melatonin Prevents Cartilage Degradation in Early‐Stage Osteoarthritis Through Activation of miR‐146a/NRF2/HO‐1 Axis
- TRPV1 Modulator Ameliorates Alzheimer-Like Amyloid-β Neuropathology via Akt/Gsk3β-Mediated Nrf2 Activation in the Neuro-2a/APP Cell Model
- Lipoxin A4 attenuates MSU-crystal-induced NLRP3 inflammasome activation through suppressing Nrf2 thereby increasing TXNRD2
- Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo
- Amentoflavone ameliorates carrageenan-induced pleurisy and lung injury by inhibiting the NF-κB/STAT3 pathways via Nrf2 activation
- Activation of Nrf2 in astrocytes suppressed PD-like phenotypes via antioxidant and autophagy pathways in rat and Drosophila models
- Activation of the Nrf2/HO-1 signaling pathway by dimethyl fumarate ameliorates complete Freund’s adjuvant-induced arthritis in rats
- Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling
- Sinomenine activation of Nrf2 signaling prevents inflammation and cerebral injury in a mouse model of ischemic stroke
- Nrf2/HO-1 signaling activator acetyl-11-keto-beta Boswellic acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-induced experimental model of ALS
- The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory …
- … suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and …
- Upregulation of antioxidant and autophagy pathways via NRF2 activation protects spinal cord neurons from ozone damage
- Immune-responsive gene 1 protects against liver injury caused by concanavalin A via the activation Nrf2/HO-1 pathway and inhibition of ROS activation pathways
- NRF2 activation inhibits valproic acid-induced neural tube defects in mice
- Ferritinophagy-mediated ferroptosis and activation of Keap1/Nrf2/HO-1 pathway were conducive to EMT inhibition of gastric cancer cells in action of 2, 2-di …
- Identification and optimization of piperlongumine analogues as potential antioxidant and anti-inflammatory agents via activation of Nrf2
- NRF2 activation induced by PML‐RARα promotes microRNA 125b‐1 expression and confers resistance to chemotherapy in acute promyelocytic leukemia
- Sodium‐glucose cotransporter‐2 inhibition reduces cellular senescence in the diabetic kidney by promoting ketone body‐induced NRF2 activation
- The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway
- Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB
- Metformin promotes osteogenic differentiation and protects against oxidative stress-induced damage in periodontal ligament stem cells via activation of the Akt/Nrf2 …
- Emodin protects against acute pancreatitis-associated lung injury by inhibiting NLPR3 inflammasome activation via Nrf2/HO-1 signaling
- Phillyrin mitigates apoptosis and oxidative stress in hydrogen peroxide-treated RPE cells through activation of the Nrf2 signaling pathway
- Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2
- Sirt6-mediated Nrf2/HO-1 activation alleviates angiotensin II-induced DNA DSBs and apoptosis in podocytes
- Tanshinone IIA prevents rifampicin‐induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2
- Zhen-Wu decoction and lactiflorin, an ingredient predicted by in silico modelling, alleviate uremia induced cardiac endothelial injury via Nrf2 activation
- Antioxidation and Nrf2-mediated heme oxygenase-1 activation contribute to renal protective effects of hydralazine in diabetic nephropathy
- Sulforaphane prevents angiotensin II‐induced cardiomyopathy by activation of Nrf2 through epigenetic modification
- Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett’s related esophageal adenocarcinoma cells
- Sulforaphane induces colorectal cancer cell proliferation through Nrf2 activation in a p53-dependent manner
- Garcinia cambogia Ameliorates Non-Alcoholic Fatty Liver Disease by Inhibiting Oxidative Stress-Mediated Steatosis and Apoptosis through NRF2-ARE Activation
- Sulforaphane inhibits NLRP3 inflammasome activation in microglia through Nrf2-mediated miRNA alteration
- … shows psycho-cardiology therapeutic effect on acute myocardial infarction with comorbid anxiety by the activation of Nrf2/HO-1 pathway and suppression of …
- Dehydroepiandrosterone attenuates LPS-induced inflammatory responses via activation of Nrf2 in RAW264. 7 macrophages
- Photodriven nanoreactor with a hydrogen-insulin double act repairs diabetic wounds through Nrf2 pathway activation
- Effects of inorganic arsenic on human prostate stem-progenitor cell transformation, autophagic flux blockade, and NRF2 pathway activation
- The protective effect of sulforaphane against oxidative stress through activation of NRF2/ARE pathway in human granulosa cells
- Alpinetin inhibits macrophage infiltration and atherosclerosis by improving the thiol redox state: Requirement of GSk3β/Fyn‐dependent Nrf2 activation
- Sestrin1 exerts a cytoprotective role against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by potentiating Nrf2 activation via the modulation of …
- Chalcone-derived Nrf2 activator protects cognitive function via maintaining neuronal redox status
- Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway
- Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling
- FAM129B‐dependent activation of NRF2 promotes an invasive phenotype in BRAF mutant melanoma cells
- Sulforaphane attenuates hexavalent chromium-induced cardiotoxicity via the activation of the Sesn2/AMPK/Nrf2 signaling pathway
- Anti-inflammatory Role of Trilobatin on Lipopolysaccharide-induced Acute Lung Injury through Activation of AMPK/GSK3β-Nrf2 Pathway.
- Pharmacological activation of Nrf2 by rosolic acid attenuates endoplasmic reticulum stress in endothelial cells
- Bisdemethoxycurcumin Attenuated Renal Injury via Activation of Keap1/Nrf2 Pathway in High-Fat Diet-Fed Mice
- Role of Nrf2 Pathway Activation in Neurological Disorder: A Brief Review
- Nrf2 activation for kidney disease treatment—a mixed blessing?
- A comparison study between dimethyl itaconate and dimethyl fumarate in electrophilicity, Nrf2 activation, and anti-inflammation in vitro
- Taraxasterol protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activation of Nrf2 signalling pathway
- Protective effects of Nrf2–ARE activator on dopaminergic neuronal loss in Parkinson disease model mice: Possible involvement of heme oxygenase-1
- Recombinant CCL17 enhances hematoma resolution and activation of CCR4/ERK/Nrf2/CD163 signaling pathway after intracerebral hemorrhage in mice
- … effects of nanoparticle-selenium, selenium-enriched yeast and sodium selenite against cadmium-induced cardiotoxicity via AHR/CAR/PXR/Nrf2 pathways activation
- Anti-inflammatory activity of the extracts from Rodgersia podophylla leaves through activation of Nrf2/HO-1 pathway, and inhibition of NF-κB and MAPKs pathway in …
- Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation
- Formononetin protects against cisplatin‑induced acute kidney injury through activation of the PPARα/Nrf2/HO‑1/NQO1 pathway
- Ellagic acid protects dopamine neurons from rotenone‐induced neurotoxicity via activation of Nrf2 signalling
- PPARγ activation mitigates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of Nrf2/HO-1 signaling pathway
- Downregulation of FOXO6 alleviates hypoxia-induced apoptosis and oxidative stress in cardiomyocytes by enhancing Nrf2 activation via upregulation of SIRT6
- Activation of Nrf2 signaling by oltipraz inhibits death of human macrophages with mycobacterium tuberculosis infection
- Erythronium japonicum Alleviates Inflammatory Pain by Inhibiting MAPK Activation and by Suppressing NF-κB Activation via ERK/Nrf2/HO-1 Signaling Pathway
- … cell apoptosis and mitochondrial dysfunction in remote lung tissue after renal ischemia and reperfusion via Nrf2 activation-mediated NLRP3 pathway …
- GYY4137 protected the integrity of the blood‐brain barrier via activation of the Nrf2/ARE pathway in mice with sepsis
- Pharmaceutical activation of Nrf2 accelerates diabetic wound healing by exosomes from bone marrow mesenchymal stem cells
- Hemistepsin A protects human keratinocytes against hydrogen peroxide-induced oxidative stress through activation of the Nrf2/HO-1 signaling pathway
- Anti-neuropathic pain activity of Ajugarin-I via activation of Nrf2 signaling and inhibition of TRPV1/TRPM8 nociceptors in STZ-induced diabetic neuropathy
- The activation of nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling blunts cholestasis-induced liver and kidney injury
- Procyanidins inhibit fine particulate matter-induced vascular smooth muscle cells apoptosis via the activation of the Nrf2 signaling pathway
- Doxorubicin cardiomyopathy is ameliorated by acacetin via Sirt1‐mediated activation of AMPK/Nrf2 signal molecules
- Alginate oligosaccharide ameliorates D-galactose-induced kidney aging in mice through activation of the Nrf2 signaling pathway
- … enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling
- Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury
- Arctiin antagonizes triptolide-induced hepatotoxicity via activation of Nrf2 pathway
- Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation
- Mitigation of Aflatoxin B1 Hepatoxicity by Dietary Hedyotis diffusa Is Associated with Activation of NRF2/ARE Signaling in Chicks
- Resveratrol and FGF1 synergistically ameliorates doxorubicin-induced cardiotoxicity via activation of SIRT1-NRF2 pathway
- Enhanced autophagy and NFE2L2/NRF2 pathway activation in SPOP mutation-driven prostate cancer
- Dimethyl fumarate and curcumin attenuate hepatic ischemia/reperfusion injury via Nrf2/HO-1 activation and anti-inflammatory properties
- Activation of Nrf2 by electrophiles is largely independent of the selenium status of HepG2 cells
- Nrf2 Activation Protects Against Organic Dust and Hydrogen Sulfide Exposure Induced Epithelial Barrier Loss and K. pneumoniae Invasion
- Asiatic acid alleviates LPS-induced acute kidney injury in broilers by inhibiting oxidative stress and ferroptosis via activation of the Nrf2 pathway
- Mechanism of Cadmium Exposure Induced Hepatotoxicity in the Mud Crab (Scylla paramamosain): Activation of Oxidative Stress and Nrf2 Signaling Pathway
- Involvement of estrogen receptor-α in the activation of Nrf2-antioxidative signaling pathways by silibinin in pancreatic β-cells
- TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling
- Luteolin prevents THP-1 macrophage pyroptosis by suppressing ROS production via Nrf2 activation
- 6′-O-galloylpaeoniflorin alleviates inflammation and oxidative stress in pediatric pneumonia through activating Nrf2 activation
- Sulforaphane inhibits the production of Aβ partially through the activation of Nrf2-regulated oxidative stress
- … saponin ameliorates myocardial infarction-induced cardiac fibrosis by targeting Keap1/Nrf2 to regulate oxidative stress and inhibit cardiac-fibroblast activation and …
- Phosphodiesterase 4B is required for NLRP3 inflammasome activation by positive feedback with Nrf2 in the early phase of LPS-induced acute lung injury
- Discovery of 4-anilinoquinolinylchalcone derivatives as potential NRF2 activators
- … of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1 Pathway
- p62-induced cancer-associated fibroblast activation via the Nrf2-ATF6 pathway promotes lung tumorigenesis
- … PC12 cells from corticosterone-induced neurotoxicity via regulation of metabolic disorders, attenuation ERK1/2-NF-κB pathway, activation Nrf2-Keap1 pathway, and …
- Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1 …
- Lutein reverses hyperglycemia-mediated blockage of Nrf2 translocation by modulating the activation of intracellular protein kinases in retinal pigment epithelial (ARPE …
- … attenuates secondary brain injury following intracerebral hemorrhage by inhibiting NLRP3 inflammasome activation and promoting Nrf2/ARE signaling pathway in …
- … Keap1-Nrf2/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1/JNK and Txnip/NLRP3 inflammasome activation
- The neuroprotective effect of phillyrin in intracerebral hemorrhagic mice is produced by activation of the Nrf2 signaling pathway
- Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation
- Arenaria kansuensis attenuates pulmonary fibrosis in mice via the activation of Nrf2 pathway and the inhibition of NF‐kB/TGF‐beta1/Smad2/3 pathway
- Activation of anti-oxidant Keap1/Nrf2 pathway modulates efficacy of dihydroartemisinin-based monotherapy and combinatory therapy with ionizing radiation
- Bdh1 overexpression ameliorates hepatic injury by activation of Nrf2 in a MAFLD mouse model
- Lipid accumulation-induced hepatocyte senescence regulates the activation of hepatic stellate cells through the Nrf2-antioxidant response element pathway
- Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway
- Sporadic activation of an oxidative stress–dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies
- Irg1-itaconate axis protects against acute kidney injury via activation of Nrf2
- Icariin protects podocytes from NLRP3 activation by Sesn2-induced mitophagy through the Keap1-Nrf2/HO-1 axis in diabetic nephropathy
- The aggravation of allergic airway inflammation with dibutyl phthalate involved in Nrf2-mediated activation of the mast cells
- IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation
- Spinal Nrf2 translocation may inhibit neuronal NF‐κB activation and alleviate allodynia in a rat model of bone cancer pain
- Combined lead and zinc oxide‐nanoparticles induced thyroid toxicity through 8‐OHdG oxidative stress‐mediated inflammation, apoptosis, and Nrf2 activation in rats
- … the main antioxidant in coffee, reduces radiation-induced apoptosis and DNA damage via NF-E2-related factor 2 (Nrf2) activation in hepatocellular carcinoma
- Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway …
- Activation of p62-NRF2 Axis protects against doxorubicin-induced ferroptosis in cardiomyocytes: a novel role and molecular mechanism of resveratrol
- Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2‑UDP glucuronosyltransferase 1A metabolic axis activation
- Cardioprotective effects of melatonin against myocardial ischaemia/reperfusion injury: Activation of AMPK/Nrf2 pathway
- Diosmetin alleviates cerebral ischemia‐reperfusion injury through Keap1‐mediated Nrf2/ARE signaling pathway activation and NLRP3 inflammasome inhibition
- Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis
- Discovery of polypodiside as a Keap1-dependent Nrf2 activator attenuating oxidative stress and accumulation of extracellular matrix in glomerular mesangial cells …
- Nrf2 activation with CDDO-Methyl promotes beneficial and deleterious clinical effects in transgenic mice with sickle cell anemia
- … extraction, characterization of a polysaccharide from Salvia miltiorrhiza Bunge and its antioxidant effects via ferroptosis-mediated activation of the Nrf2/HO-1 pathway
- Suppression of Fpr2 expression protects against endotoxin-induced acute lung injury by interacting with Nrf2-regulated TAK1 activation
- Baicalein alleviates liver oxidative stress and apoptosis induced by high-level glucose through the activation of the PERK/Nrf2 signaling pathway
- Butein ameliorates oxidative stress in H9c2 cardiomyoblasts through activation of the NRF2 signaling pathway
- … exposure triggers testicular dysfunction and oxidative stress in mice via p38/ERK MAPK inhibition and Nrf2-mediated antioxidant defense activation
- VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2/GPX4 pathway in age-related osteoporosis
- 7-hydroxycoumarin attenuates colistin-induced kidney injury in mice through the decreased level of histone deacetylase 1 and the activation of Nrf2 signaling …
- Newly synthesized chitosan-nanoparticles attenuate carbendazim hepatorenal toxicity in rats via activation of Nrf2/HO1 signalling pathway
- … microvascular endothelial cell permeability and apoptosis by reducing oxidative stress and inflammation associated with activation of Nrf2 signaling in oxygen …
- The activation of AMPK/NRF2 pathway in lung epithelial cells is involved in the protective effects of kinsenoside on lipopolysaccharide-induced acute lung …
- … protects retinal pigment epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis through the activation of Nrf2/HO-1 pathway
- … Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation
- docosahexaenoic acid esters of hydroxy fatty acid is a novel activator of NRF2
- The effect of Nrf2 activators tBHQ and 4-octyl itaconate on the nucleus pulposus cell degeneration.
- Inhibiting BTB domain and CNC homolog 1 (Bach1) as an alternative to increase Nrf2 activation in chronic diseases
- Friend or foe: xenobiotic activation of Nrf2 in disease control and cardioprotection
- Co-activation of Akt, Nrf2, and NF-κB signals under UPRER in torpid Myotis ricketti bats for survival
- Choline protects the heart from doxorubicin-induced cardiotoxicity through vagal activation and Nrf2/HO-1 pathway
- Dietary olive oil intake aggravates psoriatic skin inflammation in mice via Nrf2 activation and polyunsaturated fatty acid imbalance
- Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation
- … of amygdalin against angiotensin II induced cardiac hypertrophy, oxidative stress and inflammatory responses through modulation of Nrf2 and NF‐κB activation
- Heme-mediated activation of the Nrf2/HO-1 axis attenuates calcification of valve interstitial cells
- … protected against diabetic cardiomyopathy through inducing autophagy and reducing apoptosis relying on Nrf2 upregulation and transcription activation
- Lycopene inhibits IL-6 expression by upregulating NQO1 and HO-1 via activation of Nrf2 in ethanol/lipopolysaccharide-stimulated pancreatic acinar cells
- Leonurine inhibits the TXNIP/NLRP3 and NF‐κB pathways via Nrf2 activation to alleviate carrageenan‐induced pleurisy in mice
- Extracellular superoxide dismutase prevents skin aging by promoting collagen production through the activation of AMPK and Nrf2/HO-1 cascades
- … , ameliorates acute pancreatitis-associated liver injury partially through Nrf2-mediated antioxidant effects and inhibition of NLRP3 inflammasome activation
- … on arsenic trioxide-induced hepatic injury: involvement of suppression in oxidative stress and inflammation through activation of Nrf2 signaling pathway in …
- Sargachromenol Purified from Sargassum horneri Inhibits Inflammatory Responses via Activation of Nrf2/HO-1 Signaling in LPS-Stimulated Macrophages
- Ergosterol limits osteoarthritis development and progression through activation of Nrf2 signaling
- Chlamydia trachomatis Pgp3 protein regulates oxidative stress via activation of the Nrf2/NQO1 signal pathway
- Allicin mitigates hepatic injury following cyclophosphamide administration via activation of Nrf2/ARE pathways and through inhibition of inflammatory and apoptotic …
- … oxidized low‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling …
- Vincamine protects against cisplatin induced nephrotoxicity via activation of Nrf2/HO-1 and hindering TLR4/IFN-γ/CD44 cells inflammatory cascade
- Nrf2 regulates granuloma formation and macrophage activation during mycobacterium avium infection via mediating nramp1 and ho-1 expressions
- Loganin inhibits lipopolysaccharide-induced inflammation and oxidative response through the activation of the Nrf2/HO-1 signaling pathway in RAW264. 7 …
- Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets
- DPHC from Alpinia officinarum ameliorates oxidative stress and insulin resistance via activation of Nrf2/ARE pathway in db/db mice and high glucose-treated …
- 5-Caffeoylquinic acid ameliorates oxidative stress-mediated cell death via Nrf2 activation in hepatocytes
- Anti-Inflammatory and Anti-Oxidative Effects of luteolin-7-O-glucuronide in LPS-Stimulated Murine Macrophages through TAK1 Inhibition and Nrf2 Activation
- The activation of Nrf2/HO-1 by 8-Epi-7-deoxyloganic acid attenuates inflammatory symptoms through the suppression of the MAPK/NF-κB signaling cascade in in vitro …
- Ergothioneine alleviates senescence of fibroblasts induced by UVB damage of keratinocytes via activation of the Nrf2/HO-1 pathway and HSP70 in keratinocytes
- Andrographolide Attenuates Blood–Brain Barrier Disruption, Neuronal Apoptosis, and Oxidative Stress Through Activation of Nrf2/HO-1 Signaling Pathway in …
- Solving the problem of assessing synergy and antagonism for non-traditional dosing curve compounds using the DE/ZI method: application to Nrf2 activators
- NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway
- Activation of Nrf2 modulates protective immunity against Mycobacterium tuberculosis infection in THP1-derived macrophages
- The alleviative effect of flavonol‐type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders
- Korean Red Ginseng Extract Inhibits IL-8 Expression via Nrf2 Activation in Helicobacter pylori-Infected Gastric Epithelial Cells
- Procyanidins inhibit zearalenone-induced apoptosis and oxidative stress of porcine testis cells through activation of Nrf2 signaling pathway
- Pratensein mitigates oxidative stress and NLRP3 inflammasome activation in OGD/R-injured HT22 cells by activating Nrf2-anti-oxidant signaling
- BRG1 protects the heart from acute myocardial infarction by reducing oxidative damage through the activation of the NRF2/HO1 signaling pathway
- An Update on the Role of Nrf2 and its Activators in Diseases Associated with Oxidative Stress.
- Cadmium exposure induces rat proximal tubular cells injury via p62-dependent Nrf2 nucleus translocation mediated activation of AMPK/AKT/mTOR pathway
- Jujube (Ziziphus jujuba Mill.) Protects Hepatocytes against Alcohol-Induced Damage through Nrf2 Activation
- … effect of danshen Zexie decoction against non-alcoholic fatty liver disease through inhibition of ROS/NLRP3/IL-1β pathway by Nrf2 signaling activation
- Folic acid protects melanocytes from oxidative stress via activation of Nrf2 and inhibition of HMGB1
- Selenium-rich yeast attenuates ochratoxin A-induced small intestinal injury in broiler chickens by activating the Nrf2 pathway and inhibiting NF-KB activation
- Activation of MT1/MT2 to protect testes and leydig cells against cisplatin-induced oxidative stress through the SIRT1/Nrf2 signaling pathway
- Activation of Nrf2 pathway by dimethyl fumarate attenuates renal ischemia-reperfusion injury
- Tianxiangdan improves coronary microvascular dysfunction in rats by inhibiting microvascular inflammation via Nrf2 activation
- Exercise protects against ethanol-induced damage in rat heart and liver through the inhibition of apoptosis and activation of Nrf2/Keap-1/HO-1 pathway
- Nanocurcumin alleviates inflammation and oxidative stress in LPS-induced mastitis via activation of Nrf2 and suppressing TLR4-mediated NF-κB and HMGB1 …
- Nattokinase attenuates bisphenol A or gamma irradiation-mediated hepatic and neural toxicity by activation of Nrf2 and suppression of inflammatory …
- Autophagy assuages myocardial infarction through Nrf2 signaling activation-mediated reactive oxygen species clear.
- Protective effects of rare earth lanthanum on acute ethanol-induced oxidative stress in mice via Keap 1/Nrf2/p62 activation
- Sitagliptin Alleviates Radiation-Induced Intestinal Injury by Activating NRF2-Antioxidant Axis, Mitigating NLRP3 Inf–lammasome Activation, and Reversing Gut …
- Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway
- NRF2 activator A-1396076 ameliorates inflammation in autoimmune disease models by inhibiting antigen dependent T cell activation
- DL0410 attenuates oxidative stress and neuroinflammation via BDNF/TrkB/ERK/CREB and Nrf2/HO-1 activation
- Function‐Oriented and Modular (+/−)‐cis‐Pseudoguaianolide Synthesis: Discovery of New Nrf2 Activators and NF‐κB Inhibitors
- Suppression of LPS-induced inflammation by chalcone flavokawain a through activation of Nrf2/ARE-mediated antioxidant genes and inhibition of ROS/NFκB …
- Galangin ameliorates Imiquimod-Induced psoriasis-like skin inflammation in BALB/c mice via down regulating NF-κB and activation of Nrf2 signaling pathways
- Urolithin A ameliorates diabetic retinopathy via activation of the Nrf2/HO-1 pathway
- Chrysin attenuates high glucose-induced BMSC dysfunction via the activation of the PI3K/AKT/Nrf2 signaling pathway
- … oxalate-induced epithelial-mesenchymal transition of renal tubular cells by its anti-oxidative property through activation of Nrf2 signaling and suppression of …
- … from bone marrow mesenchymal stem cells pretreated with berberine rescues neurons with oxidative damage through activation of the Keap1-Nrf2-HO-1 signaling …
- The skin-whitening effects of ectoine via the suppression of α-MSH-stimulated melanogenesis and the activation of antioxidant Nrf2 pathways in UVA-irradiated …
- Activation of autophagy by sitagliptin attenuates cadmium-induced testicular impairment in rats: Targeting AMPK/mTOR and Nrf2/HO-1 pathways
- Protective effects of 1, 25 dihydroxyvitamin D3 against high-glucose-induced damage in human umbilical vein endothelial cells involve activation of Nrf2 antioxidant …
- A hydrogen peroxide responsive prodrug of Keap1-Nrf2 inhibitor for improving oral absorption and selective activation in inflammatory conditions
- Involvement of Nrf2 and Keap1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent peptides from soft-shelled turtle
- Melatonin suppresses Ti-particle-induced inflammatory osteolysis via activation of the Nrf2/Catalase signaling pathway
- MiR-30a-3p ameliorates oxidative stress in rheumatoid arthritis synovial fibroblasts via activation of Nrf2-ARE signaling pathway
- EGF released from human placental mesenchymal stem cells improves premature ovarian insufficiency via NRF2/HO-1 activation
- … AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl 4: roles in the activation of the Nrf2 cascade and subsequent …
- Nrf2 activation mediates the protection of mouse Sertoli Cells damage under acute heat stress conditions
- Hesperidin ameliorates hypobaric hypoxia-induced retinal impairment through activation of Nrf2/HO-1 pathway and inhibition of apoptosis
- The combination of NRF1 and Nrf2 activators in myoblasts stimulate mechanisms of proteostasis without changes in mitochondrial respiration
- Gastrodin pretreatment protects liver against ischemia-reperfusion injury via activation of the Nrf2/HO-1 pathway
- … effect of astaxanthin on blue light light-emitting diode-induced retinal cell damage via free radical scavenging and activation of PI3K/Akt/Nrf2 pathway in 661W cell …
- Melatonin inhibits the apoptosis of rooster Leydig cells by suppressing oxidative stress via AKT-Nrf2 pathway activation
- Lycopene mitigates arsenic-induced nephrotoxicity with activation of the Nrf2 pathway in mice
- Sodium tanshinone IIA sulfonate attenuates silica-induced pulmonary fibrosis in rats via activation of the Nrf2 and thioredoxin system
- Polysaccharides from Enteromorpha prolifera protect against carbon tetrachloride-induced acute liver injury in mice via activation of Nrf2/HO-1 signaling, and …
- Astaxanthin protects human granulosa cells against oxidative stress through activation of NRF2/ARE pathway and its downstream phase II enzymes
- Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter
- Rg1 protects H9C2 cells from high glucose‐/palmitate‐induced injury via activation of AKT/GSK‐3β/Nrf2 pathway
- … lysosomal membrane permeabilization and leads to ferroptosis insensitivity via the autophagy dysfunction/p62-KEAP1-NRF2 activation in neuronal cells
- Berbamine induced AMPK activation regulates mTOR/SREBP-1c axis and Nrf2/ARE pathway to allay lipid accumulation and oxidative stress in steatotic HepG2 cells
- Modified Qing’e Formula protects against UV-induced skin oxidative damage via the activation of Nrf2/ARE defensive pathway
- Activation of AMPK/p38/Nrf2 is involved in resveratrol alleviating myocardial ischemia-reperfusion injury in diabetic rats as an endogenous antioxidant stress …
- Solasonine alleviates high glucose‐induced podocyte injury through increasing Nrf2‐medicated inhibition of NLRP3 activation
- The gut-microbiota-testis axis mediated by the activation of the Nrf2 antioxidant pathway is related to prepuberal steroidogenesis disorders induced by di-(2-ethylhexyl …
- Dimethyl fumarate alleviates dextran sulfate sodium-induced colitis, through the activation of Nrf2-mediated antioxidant and anti-inflammatory pathways
- Nattokinase attenuates retinal neovascularization via modulation of Nrf2/HO-1 and glial activation
- Activation of nrf2/ho-1 by peptide yd1 attenuates inflammatory symptoms through suppression of tlr4/myyd88/nf-κb signaling cascade
- Protective effect of lemon peel polyphenols on oxidative stress-induced damage to human keratinocyte hacat cells through activation of the nrf2/ho-1 signaling …
- Antiaging function of Chinese pond turtle (Chinemys reevesii) peptide through activation of the Nrf2/Keap1 signaling pathway and its structure-activity …
- Capsaicin prevents contrast-associated acute kidney injury through activation of Nrf2 in mice
- Synthesis and biological evaluation of 1, 2, 4-triazole derivatives as potential Nrf2 activators for the treatment of cerebral ischemic injury
- Hydrogen sulfide protects against ammonia-induced neurotoxicity through activation of Nrf2/ARE signaling in astrocytic model of hepatic encephalopathy
- Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile …
- Activation of the PPARγ prevents ferroptosis-induced neuronal loss in response to intracerebral hemorrhage through synergistic actions with the Nrf2
- Discovery of cinnamamide-barbiturate hybrids as a novel class of Nrf2 activator against myocardial ischemia/reperfusion injury
- Immune response gene 1 deficiency impairs Nrf2 activation and aggravates liver fibrosis in mice
- iTRAQ-based quantitative proteomics indicated Nrf2/OPTN-mediated mitophagy inhibits NLRP3 inflammasome activation after intracerebral hemorrhage
- Activation of Nrf2 by Lithospermic Acid Ameliorates Myocardial Ischemia and Reperfusion Injury by Promoting Phosphorylation of AMP-Activated Protein Kinase α …
- Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine
- … /D-Galactosamine-Induced Acute Liver Failure by Upregulating the Nrf2 Pathway and Inhibiting NF-κB, MAPK, and NLRP3 Inflammasome Activation
- Human Placental Extract Delays In Vitro Cellular Senescence through the Activation of NRF2-Mediated Antioxidant Pathway
- NXP032 ameliorates aging-induced oxidative stress and cognitive impairment in mice through activation of Nrf2 signaling
- Ferulic acid induces keratin 6α via inhibition of nuclear β-catenin accumulation and activation of Nrf2 in wound-induced inflammation
- Electrophilic thymol isobutyrate from Inula nervosa Wall.(Xiaoheiyao) ameliorates steatosis in HepG2 cells via Nrf2 activation
- Spermidine inhibits LPS-induced pro-inflammatory activation of macrophages by acting on Nrf2 signaling but not autophagy
- Activation of the Nrf2 response by oleanolic acid oxime morpholide (3-hydroxyiminoolean-12-en-28-oic acid morpholide) is associated with its ability to induce …
- Castor Oil Plant (Ricinus communis L.) Leaves Improve Dexamethasone-Induced Muscle Atrophy via Nrf2 Activation
- Oligo-fucoidan improves diabetes-induced renal fibrosis via activation of sirt-1, glp-1r, and nrf2/ho-1: An in vitro and in vivo study
- Sagittaria sagittifolia polysaccharide protects against six-heavy-metal-induced hepatic injury associated with the activation of Nrf2 pathway to regulate oxidative stress …
- Brain Protection by Methylene Blue and Its Derivative, Azur B, via Activation of the Nrf2/ARE Pathway in Cisplatin-Induced Cognitive Impairment
- Lignans from Eucommia ulmoides Oliver leaves exhibit neuroprotective effects via activation of the PI3K/Akt/GSK-3β/Nrf2 signaling pathways in H2O2-treated PC-12 …
- … chinense Pursh attenuates hepatic ischemia/reperfusion injury by suppressing oxidative stress and inflammation through activation of the Nrf2/HO-1 signaling …
- Acertannin attenuates LPS-induced inflammation by interrupting the binding of LPS to the TLR4/MD2 complex and activating Nrf2-mediated HO-1 activation
- … (Xingxiong injection) protects against focal cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome activation
- Neuroprotective effect of apigenin against hypoxic-ischemic brain injury in neonatal rats via activation of the PI3K/Akt/Nrf2 signaling pathway
- Chlorogenic Acid Activates Nrf2/SKN-1 and Prolongs the Lifespan of Caenorhabditis elegans via the Akt-FOXO3/DAF16a-DDB1 Pathway and Activation of DAF16f
- Early growth response 1 suppresses macrophage phagocytosis by inhibiting NRF2 activation through upregulation of autophagy during Pseudomonas …
- n-BuOH extract of Bletilla striata exerts chemopreventive effects on lung against SiO2 nanoparticles through activation of Nrf2 pathway
- Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of platycodin D against oxidative stress-induced DNA damage and apoptosis in …
- Lablab purpureus protects HaCaT cells from oxidative stress-induced cell death through Nrf2-mediated heme oxygenase-1 expression via the activation of p38 and …
- Vernonia patula (Dryand.) Merr. and Leucas chinensis (Retz.) R. Brown exert anti-inflammatory activities and relieve oxidative stress via Nrf2 activation
- Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension …
- Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation
- Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function
- The potential of Nrf2 activation as a therapeutic target in systemic lupus erythematosus
- Suppressive role of microRNA-130b-3p in ferroptosis in melanoma cells correlates with DKK1 inhibition and Nrf2-HO-1 pathway activation
- … cardiomyocytes from hypoxia/reoxygenation‐induced injury by inhibiting apoptosis, oxidative stress, and inflammatory response via enhancing Nrf2/ARE activation
- Polysaccharides extracted from Rheum tanguticum ameliorate radiation-induced enteritis via activation of Nrf2/HO-1
- Hepatoprotective effect of neoagarooligosaccharide via activation of Nrf2 and enhanced antioxidant efficacy
- Eletrophilic chemistry of tranilast is involved in its anti-colitic activity via Nrf2-HO-1 pathway activation
- Saikosaponin-D mitigates oxidation in SH-SY5Y cells stimulated by glutamate through activation of Nrf2 pathway: involvement of PI3K
- Induction of HO-1 by 5, 8-dihydroxy-4, 7-dimethoxyflavone via activation of ROS/p38 MAPK/Nrf2 attenuates thrombin-induced connective tissue growth factor …
- The potential for reducing Lynch syndrome cancer risk with nutritional Nrf2 activators
- Herba houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade
- Aloperine protects human retinal pigment epithelial cells against hydrogen peroxide–induced oxidative stress and apoptosis through activation of Nrf2/HO-1 pathway
- Ferulic acid prevents cyclosporine-induced nephrotoxicity in rats through exerting anti-oxidant and anti-inflammatory effects via activation of Nrf2/HO-1 signaling and …
- Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/HO-1 signaling
- Cytoprotective effects of fermented oyster extracts against oxidative stress-induced DNA damage and apoptosis through activation of the Nrf2/HO-1 signaling …
- Atractylenolide III attenuates bleomycin-induced experimental pulmonary fibrosis and oxidative stress in rat model via Nrf2/NQO1/HO-1 pathway activation
- Yinhuang oral liquid protects acetaminophen-induced acute liver injury by regulating the activation of autophagy and Nrf2 signaling
- Vitexin attenuates autoimmune hepatitis in mouse induced by syngeneic liver cytosolic proteins via activation of AMPK/AKT/GSK-3β/Nrf2 pathway
- Quercetin supports bovine preimplantation embryo development under oxidative stress condition via activation of the Nrf2 signalling pathway
- Minocycline inhibits sleep deprivation-induced aberrant microglial activation and Keap1-Nrf2 expression in mouse hippocampus
- Betanin ameliorates fipronil-induced nephrotoxicity via activation of Nrf2-HO-1/NQO-1 pathway in albino rat model
- … protective effect of sulforaphane against oxidative stress in granulosa cells of patients with polycystic ovary syndrome (PCOS) through activation of AMPK/AKT/NRF2 …
- α‐Lipoic acid protects against microcystin‐LR induced hepatotoxicity through regeneration of glutathione via activation of Nrf2
- Activation of the Nrf2/HO-1 Pathway by Amomum villosum Extract Suppresses LPS-Induced Oxidative Stress In Vitro and Ex Vivo
- Activation of AdipoR1 with rCTRP9 preserves BBB integrity through the APPL1/AMPK/Nrf2 signaling pathway in ICH mice
- Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation
- Design and evaluation of Nrf2 activators with 1, 3, 4-oxa/thiadiazole core as neuro-protective agents against oxidative stress in PC-12 cells
- Glaucocalyxin A protects H9c2 cells against hypoxia/reoxygenation-induced injury through the activation of Akt/Nrf2/HO-1 pathway
- Activation of M3AChR (type 3 muscarinic acetylcholine receptor) and Nrf2 (nuclear factor erythroid 2–related factor 2) signaling by choline alleviates vascular smooth …
- Dieckol alleviates dextran sulfate sodium‐induced colitis via inhibition of inflammatory pathway and activation of Nrf2/HO‐1 signaling pathway
- Dimethyl itaconate protects against lipopolysaccharide-induced endometritis by inhibition of TLR4/NF-κB and activation of Nrf2/HO-1 signaling pathway in …
- … Sargassum horneri Attenuates Glutamate-Induced Neuronal Cell Death and Oxidative Stress through Inhibition of MAPK/NF-κB and Activation of Nrf2/HO-1 Signaling …
- The Keap1/Nrf2-ARE signaling pathway is involved in atrazine induced dopaminergic neurons degeneration via microglia activation
- Impact of the ACE2 activator xanthenone on tacrolimus nephrotoxicity: Modulation of uric acid/ERK/p38 MAPK and Nrf2/SOD3/GCLC signaling pathways
- Spiraeoside protects human cardiomyocytes against high glucose‐induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway
- Inhibition of CYP2E1 and activation of Nrf2 signaling pathways by a fraction from Entada africana alleviate carbon tetrachloride-induced hepatotoxicity
- Hydrogen Sulfide Donor GYY4137 Rescues NRF2 Activation in Respiratory Syncytial Virus Infection
- Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in …
- … of PHLPP1 ameliorates high glucose-evoked injury in retinal ganglion cells by attenuating apoptosis and oxidative stress through enhancement of Nrf2 activation
- … -related renal fibrosis by inhibition of inflammation mediated by NF-κB and TGF-β1/Smad signaling and suppression of oxidative stress via activation of Nrf2 …
- Bisphenol A stabilizes Nrf2 via Ca2+ influx by direct activation of the IP3 receptor
- Roles of JNK/Nrf2 pathway on hemin-induced heme oxygenase-1 activation in MCF-7 human breast cancer cells
- Soy Isoflavones Protect Neuronal PC12 Cells against Hypoxic Damage through Nrf2 Activation and Suppression of p38 MAPK and AKT–mTOR Pathways
- Akt/GSK3β/Nrf2/HO-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity
- … acid, a cyclooxygenase-2 inhibitor, attenuates inflammatory responses by regulating NF-κB Inactivation and Nrf2 activation in lipopolysaccharide-stimulated cells
- Protective effect of USP22 against paraquat-induced lung injury via activation of SIRT1/NRF2 pathway.
- Upregulation of Nrf2 attenuates oxidative stress–induced, complement activation–associated endothelial injury and apoptosis in transplant-associated …
- Tanshinone IIA prevents acetaminophen‐induced nephrotoxicity through the activation of the Nrf2‐Mrp2/4 pathway in mice
- Activation of Atg7-dependent autophagy by a novel inhibitor of the Keap1–Nrf2 protein–protein interaction from Penthorum chinense Pursh. attenuates 6 …
- Activation of Akt‐dependent Nrf2/ARE pathway by restoration of Brg‐1 remits high glucose‐induced oxidative stress and ECM accumulation in podocytes
- H2O2/DEM-Promoted Maft Promoter Demethylation Drives Nrf2/ARE Activation in Zebrafish
- Vinpocetine reduces cisplatin-induced acute kidney injury through inhibition of NF–κB pathway and activation of Nrf2/ARE pathway in rats
- Mogroside V alleviates lipopolysaccharide-induced neuroinflammation via inhibition of TLR4-MyD88 and activation of AKT/AMPK-Nrf2 signaling pathway
- Downregulation of P300/CBP-associated factor protects from vascular aging via Nrf2 signal pathway activation
- Effect of sulfasalazine on endothelium-dependent vascular response by the activation of Nrf2 signalling pathway
- Agmatine-mediated inhibition of NMDA receptor expression and amelioration of dyskinesia via activation of Nrf2 and suppression of HMGB1/RAGE/TLR4/MYD88/NF …
- … japonicus suppresses hepatocyte EMT and HSC activation in vitro and CCl4-provoked liver fibrosis in mice: Roles of its modulatory effects on the Akt/GSK3β/Nrf2 …
- Ribisins and Certain Analogues Exert Neuroprotective Effects through Activation of the Keap1‐Nrf2‐ARE Pathway
- Activation of the melanocortin-1 receptor by NDP-MSH attenuates oxidative stress and neuronal apoptosis through PI3K/Akt/Nrf2 pathway after intracerebral …
- Gut bacterial metabolite Urolithin A inhibits myocardial fibrosis through activation of Nrf2 pathway in vitro and in vivo
- Opuntia ficus indica (L.) fruit extract alleviates oxidative stress through activation of dual oxidases and Keap1/Nrf2 signaling cascades in high-fat-diet associated …
- Artemisia judaica L. diminishes diabetes-induced reproductive dysfunction in male rats via activation of Nrf2/HO-1-mediated antioxidant responses
- Physiological Concentration of H2O2 Supports Dopamine Neuronal Survival via Activation of Nrf2 Signaling in Glial Cells
- Ketone analog of caffeic acid phenethyl ester exhibits antioxidant activity via activation of ERK-dependent Nrf2 pathway
- Activation of Nrf2/HO‐1 signaling pathway attenuates ROS‐mediated autophagy induced by silica nanoparticles in H9c2 cells
- Activation of KEAP1/NRF2 stress signaling involved in the molecular basis of hemin-induced cytotoxicity in human pro-erythroid K562 cells
- … B surface peptide protects against acute lung injury through reducing oxidative stress and endoplasmic reticulum stress via activation of Nrf2/HO-1 signaling …
- Activation of Nrf2 in Mice Causes Early Microvascular Cyclooxygenase-Dependent Oxidative Stress and Enhanced Contractility
- … 2-related factor 2 (Nrf2), protects against the formation of BAPN-induced aneurysms and dissection of the thoracic aorta in mice by inhibiting activation of the ROS …
- Gnaq protects PC12 cells from oxidative damage by activation of Nrf2 and inhibition of NF-kB
- tert‐Butylhydroquinone‐induced formation of high‐molecular‐weight p62: A novel mechanism in the activation of Nrf2‐Keap1
- Identification of Novel Nrf2 Activator via Protein-ligand Interactions as Remedy for Oxidative Stress in Diabetes Mellitus
- Apomorphine reduces A53T α-synuclein-induced microglial reactivity through activation of NRF2 signalling pathway
- Shockwave treatment enhanced extracellular matrix production in articular chondrocytes through activation of the ROS/MAPK/Nrf2 signaling pathway
- HIF-1α and Nrf2 regulates hypoxia induced overexpression of DDAH1 through promoter activation in prostate cancer
- … of ergothioneine in UVA-irradiated human dermal fibroblasts via the inhibition of the AP-1 pathway and the activation of Nrf2-mediated antioxidant genes
- Thioredoxin reductase-1 levels are associated with NRF2 pathway activation and tumor recurrence in non-small cell lung cancer
- Activation of the Nrf2/ARE signaling pathway protects against palmitic acid-induced renal tubular epithelial cell injury by ameliorating mitochondrial reactive …
- Early neurotoxic effects of inorganic arsenic modulate cortical GSH levels associated with the activation of the Nrf2 and NFκB pathways, expression of amino …
- Phytoconstituents of Sansevieria suffruticosa NEBr. Leaves and Its Hepatoprotective Effect via Activation of the NRF2/ARE Signaling Pathway in an Experimentally …
- Apigenin-7-O-β-D-(-6”-p-coumaroyl)-glucopyranoside treatment elicits a neuroprotective effect through GSK-3β phosphorylation-mediated Nrf2 activation
- Paraoxonase 2 protects against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by enhancing Nrf2 activation via GSK-3β modulation
- Trans-anethole Ameliorates Intestinal Injury Through Activation of Nrf2 Signaling Pathway in Subclinical Necrotic Enteritis-Induced Broilers
- … resistance of head and neck squamous cell carcinoma is mediated by EpCAM induction driven by IL-6/p62 associated Nrf2-antioxidant pathway activation
- RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma
- Mistimed H2S upregulation, Nrf2 activation and antioxidant proteins levels in renal tubular epithelial cells subjected to anoxia and reoxygenation
- Guan Xin Dan Shen formulation protects db/db mice against diabetic cardiomyopathy via activation of Nrf2 signaling
- Protective effects of Hirudin against compartment syndrome in rabbits through the activation of Nrf2/HO-1
- Genetic activation of Nrf2 reduces cutaneous symptoms in a murine model of Netherton syndrome
- Parthenolide inhibits lipid accumulation via activation of Nrf2/Keap1 signaling during adipocyte differentiation
- Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic–ischemic injury in rats
- Activation of Nrf2 by lead sulfide nanoparticles induces impairment of learning and memory
- Formononetin attenuates Aβ25-35-induced adhesion molecules in HBMECs via Nrf2 activation
- Arsenite inhibits tissue-type plasminogen activator synthesis through NRF2 activation in cultured human vascular endothelial EA. hy926 cells
- Shinorine ameliorates chromium induced toxicity in zebrafish hepatocytes through the facultative activation of Nrf2-Keap1-ARE pathway
- … against Oxidative Stress by Methylnissolin-3-O-β-d-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway
- … of Sansevieria trifasciata hort ex. Prain leaves and roots by HPLC-PAD-ESI/MS and its hepatoprotective effect via activation of the NRF2/ARE signaling pathway in an …
- … of endotoxin-induced acute lung injury in rats by bone marrow–derived mesenchymal stem cells: Role of Nrf2/HO-1 signal axis in inhibition of NLRP3 activation
- Activation of Nrf2 signaling by apelin attenuates renal ischemia reperfusion injury in diabetic rats
- … ) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of …
- Activation of the PDGFRα-Nrf2 pathway mediates impaired adipocyte differentiation in bone marrow mesenchymal stem cells lacking Nck1
- 6-Shogaol protects human melanocytes against oxidative stress through activation of the Nrf2-antioxidant response element signaling pathway
- Arctiin suppresses H9N2 avian influenza virus-mediated inflammation via activation of Nrf2/HO-1 signaling
- Activation of Nrf2 by methylene blue is associated with the neuroprotection against MPP+ induced toxicity via ameliorating oxidative stress and mitochondrial …
- Synthesis and Anti‐Inflammatory Activity of 2‐Amino‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐Derived NRF2 Activators
- Apigenin attenuates high-fat diet-induced nephropathy in rats by hypoglycemic and hypolipidemic effects, and concomitant activation of the Nrf2/antioxidant …
- Protective effect of MitoQ on oxidative stress-mediated senescence of canine bone marrow mesenchymal stem cells via activation of the Nrf2/ARE pathway
- Melatonin attenuates restenosis after vascular injury in diabetic rats through activation of the Nrf2 signaling pathway
- Mn-TAT PTD-Ngb ameliorates inflammation through the elimination of damaged mitochondria and the activation of Nrf2-antioxidant signaling pathway
- Curcumin activation of nuclear factor E2-related factor 2 gene (Nrf2): Prophylactic and therapeutic effect in nonalcoholic steatohepatitis (NASH)
- 1, 25-Dihydroxyvitamin D3 attenuates IL-1β secretion by suppressing NLRP1 inflammasome activation by upregulating the NRF2-HO-1 pathway in epidermal …
- Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling
- Near-infrared Nrf2 activator IR-61 dye alleviates radiation-induced lung injury
- S-Allylcysteine Protects Against Excitotoxic Damage in Rat Cortical Slices Via Reduction of Oxidative Damage, Activation of Nrf2/ARE Binding, and BDNF …
- Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function
- Nrf2/ARE pathway activation is involved in negatively regulating heat-induced apoptosis in non-small cell lung cancer cells
- Activation of Nrf2 decreases bile acid concentrations in livers of female mice
- Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11. 1 activation in breast cancer cells and …
- Suppression of bromodomain-containing protein 4 protects trophoblast cells from oxidative stress injury by enhancing Nrf2 activation
- Ellagic acid improved diabetes mellitus-induced testicular damage and sperm abnormalities by activation of Nrf2
- Cerevisterol alleviates inflammation via suppression of MAPK/NF-κB/AP-1 and activation of the Nrf2/HO-1 signaling cascade
- The protective effect of isoliquiritigenin against doxorubicin-induced nephropathy in rats entails activation of Nrf2 signaling as one key mechanism
- The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy
- Nrf2 axis and endoplasmic reticulum stress mediated autophagy activation is involved in molybdenum and cadmium co-induced hepatotoxicity in ducks
- Epigallocatechin 3-Gallate has a neuroprotective effect in retinas of rabbits with ischemia/reperfusion through the activation of Nrf2/HO-1
- GSKIP protects cardiomyocytes from hypoxia/reoxygenation-induced injury by enhancing Nrf2 activation via GSK-3β inhibition
- Activation of Nrf2/HO-1 antioxidant pathway by heme attenuates calcification of human lens epithelial cells
- Evaluating skin cancer chemopreventive potential of water extract of Syzygium samarangense leaves through activation of the Nrf2-mediated cellular defense …
- Cryptotanshinone protects hippocampal neurons against oxygen-glucose deprivation-induced injury through the activation of Nrf2/HO-1 signaling pathway
- α-Bisabolol Attenuates NF-κB/MAPK Signaling Activation and ER-Stress-Mediated Apoptosis by Invoking Nrf2-Mediated Antioxidant Defense Systems against …
- Oridonin attenuates carrageenan-induced pleurisy via activation of the KEAP-1/Nrf2 pathway and inhibition of the TXNIP/NLRP3 and NF-κB pathway in mice
- Berberine attenuates cholesterol accumulation in macrophage foam cells by suppressing AP-1 activity and activation of the Nrf2/HO-1 pathway
- Rosemary extract reverses oxidative stress through activation of Nrf2 signaling pathway in hamsters fed on high fat diet and HepG2 cells
- lncRNA Eif4g2 improves palmitate-induced dysfunction of mouse β-cells via modulation of Nrf2 activation
- … Effects of Heterotrigona itama (Stingless Bee) Bee Bread in Improving Hepatic Lipid Metabolism through the Activation of the Keap1/Nrf2 Signaling Pathway in an …
- … of a Natural Flavanol 3,3′-Diindolylmethane against CCl4-Induced Chronic Liver Injury in Mice and TGFβ1-Induced EMT in Mouse Hepatocytes via Activation of Nrf2 …
- … from Potentilla fragarioides ameliorates high glucose-induced oxidative stress and accumulation of ECM in mesangial cells via Keap1-dependent activation of Nrf2
- Proteomic examination of Cornus officinalis stimulated 1.1 B4 human pancreatic cells reveals activation of autophagy and Keap1/Nrf2 pathway
- The antibiotic cefotaxime works as both an activator of Nrf2 and an inducer of HSP70 in mammalian cells
- … Oxidative Stress-Induced Apoptosis by Fermented Sea Tangle (Laminaria japonica Aresch) in Osteoblastic MC3T3-E1 Cells through Activation of Nrf2 …
- C1q/TNF-related Protein 9 Inhibits High Glucose–Induced Oxidative Stress and Apoptosis in Retinal Pigment Epithelial Cells Through the Activation of AMPK/Nrf2 …
- Schisandra chinensis (Turcz.) Baill. essential oil exhibits antidepressant-like effects and against brain oxidative stress through Nrf2/HO-1 pathway activation
- Coptisine ameliorates renal injury in diabetic rats through the activation of Nrf2 signaling pathway
- D-Cysteine Activates Chaperone-Mediated Autophagy in Cerebellar Purkinje Cells via the Generation of Hydrogen Sulfide and Nrf2 Activation
- Identification of Nrf2 Activators from the Roots of Valeriana officinalis
- NRF2 activation by 2-methoxycinnamaldehyde attenuates inflammatory responses in macrophages via enhancing autophagy flux
- Methamphetamine and HIV-1 Tat proteins synergistically induce microglial autophagy via activation of the Nrf2/NQO1/HO-1 signal pathway
- Harpagophytum procumbens Inhibits Iron Overload-Induced Oxidative Stress through Activation of Nrf2 Signaling in a Rat Model of Lumbar Spinal Stenosis
- Semisynthetic quercetin-quinone mitigates BV-2 microglia activation through modulation of Nrf2 pathway
- Activation of the Nrf2 pathway prevents mitochondrial dysfunction induced by caspase-3 cleaved tau: implications for Alzheimer’s disease
- Nrf2 Activation Enhances Muscular MCT1 Expression and Hypoxic Exercise Capacity.
- Nrf2/Keap1-pathway activation and reduced susceptibility to chemotherapy treatment by acidification in esophageal adenocarcinoma cells
- Keap1-targeting microRNA-941 protects endometrial cells from oxygen and glucose deprivation-re-oxygenation via activation of Nrf2 signaling
- Olive oil promotes the survival and migration of dermal fibroblasts through Nrf2 pathway activation.
- … Hyperplasia In Vivo and Vascular Smooth Muscle Cell Dedifferentiation, Proliferation, and Migration In Vitro via Activation of the Keap1-Nrf2-ARE Antioxidant System
- NRF2 Activation in Autophagy Defects Suppresses a Pharmacological Transactivation of the Nuclear Receptor FXR
- Nrf2 Mediated Heme Oxygenase-1 Activation Contributes to Diabetic Wound Healing–an Overview
- Quercetin protects the buffalo rat liver (BRL-3A) cells from aflatoxin B1-induced cytotoxicity via activation of Nrf2-ARE pathway
- Aldosterone Induces DNA Damage and Activation of Nrf2 Mainly in Tubuli of Mouse Kidneys
- … oxygen‑glucose deprivation/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/Nrf2 signaling pathway in …
- … Human In Vitro Intestinal Microbial Conversion of Green Tea (‐)‐Epigallocatechin‐3‐O‐Gallate and Consequences for Activation of Nrf2 Mediated Gene Expression
- Isoorientin Alleviates Inflammatory Bowel Disease by Inhibiting NLRP3 Inflammasome Activation through Nrf2/NQO1 Pathway.
- Activation of the Nrf2 Antioxidant Pathway by Longjing Green Tea Polyphenols in Mice Livers
- SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1
- Exendin-4 protects human retinal pigment epithelial cells from H2O2-induced oxidative damage via activation of NRF2 signaling
- Ephedrine ameliorates cerebral ischemia injury via inhibiting NOD-like receptor pyrin domain 3 inflammasome activation through the Akt/GSK3β/NRF2 pathway
- ALK7 Knockdown Plays a Protective Role on HG-Stimulated MCs through Activation of the Nrf2/HO-1 Pathway
- Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/keap1 pathway
- Trehalose prevents glyphosate-induced hepatic steatosis in roosters by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation
- Metabolic activation of retrorsine may disrupt bile acid homeostasis in mice through the Nrf2 pathway
- Dual proteotoxic stress accelerates liver injury via activation of p62‐Nrf2
- Edaravone dexborneol alleviates cerebral ischemic injury via MKP-1-mediated inhibition of MAPKs and activation of Nrf2
- Green tea polyphenols cause apoptosis and autophagy in HPV-16 subgene-immortalized human cervical epithelial cells via the activation of the Nrf2 pathway
- Oxyresveratrol-induced activation of Nrf2/HO-1 signaling pathway enhances ability of resveratrol to inhibit UVB-induced melanin
- NOX4 stimulates ANF secretion via activation of the Sirt1/Nrf2/ATF3/4 axis in hypoxic beating rat atria
- Ischemic postconditioning-mediated DJ-1 activation mitigate intestinal mucosa injury induced by myocardial ischemia reperfusion in rats through Keap1/Nrf2 …
- Identification of a potent Nrf2 displacement activator among aspirin-containing prodrugs
- Human papillomavirus 16 E7 promotes EGFR/PI3K/AKT1/NRF2 signaling pathway contributing to PIR/NF-κB activation in oral cancer cells
- Ginsenoside Rb1 Attenuates Triptolide-Induced Cytotoxicity in HL-7702 Cells via the Activation of Keap1/Nrf2/ARE Pathway
- (±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to H2O2 Through Activation of Nrf2 …
- … Alzheimer’s disease progression and prevents the exacerbation of cardiovascular dysfunction of socially isolated depressed rats through activation of Nrf2/HO-1 and …
- 7-deacetyl-gedunin suppresses proliferation of Human rheumatoid arthritis synovial fibroblast through activation of Nrf2/ARE signaling
- … of leaf and branch extracts of honeyberry (Lonicera caerulea) on lipopolysaccharide‑stimulated RAW264. 7 cells through ATF3 and Nrf2/HO‑1 activation
- Notoginsenoside R1 alleviates TEGDMA-induced mitochondrial apoptosis in preodontoblasts through activation of Akt/Nrf2 pathway-dependent mitophagy
- Hepatocyte-Specific Deficiency of BAP31 Amplified Acetaminophen-Induced Hepatotoxicity via Attenuating Nrf2 Signaling Activation in Mice
- Catalpol protects arpe-19 cells against oxidative stress via activation of the keap1/nrf2/are pathway
- … impairment of late-stage autophagic flux in murine splenocytes leads to sqstm1/p62 mediated nrf2-keap1 antioxidant pathway activation and induced proteasome …
- Comparative effectiveness of 4 natural and chemical activators of Nrf2 on inflammation, oxidative stress, macrophage polarization, and bactericidal activity in …
- Mechanisms and therapeutic implications of RTA 408, an activator of Nrf2, in subarachnoid hemorrhage–induced delayed cerebral vasospasm and …
- Sevoflurane preconditioning prevents acute renal injury caused by ischemia‑reperfusion in mice via activation of the Nrf2 signaling pathway
- CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes
- Neuroprotective Effects of Rhynchophylline Against Aβ1–42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2–ARE Activation
- Protective Effect of Alpinia oxyphylla Fruit against tert-Butyl Hydroperoxide-Induced Toxicity in HepG2 Cells via Nrf2 Activation and Free Radical Scavenging …
- Diastereoselective Copper-Mediated Conjugate Addition of Functionalized Magnesiates for the Preparation of Bisaryl Nrf2 Activators
- Carvedilol and rosuvastatin mitigate nephrotoxicity of sodium valproate through activation of Nrf2 pathway in rats.
- Nrf2 Activation in Chronic Kidney Disease: Promises and Pitfalls. Antioxidants 2022, 11, 1112
- Inhibition of MRP1 Induces Fetal Hemoglobin through NRF2 Activation to Protect Human Erythroid Cells from Sickling
- Methyl 6-O-cinnamoyl-α-d-glucopyranoside ameliorates acute liver injury by inhibiting oxidative stress through the activation of Nrf2 signaling pathway
- TBHQ attenuates ferroptosis against 5-fluorouracil-induced intestinal epithelial cell injury and intestinal mucositis via activation of Nrf2
- QSAR study, molecular docking, and ADMET prediction of vinyl sulfone-containing Nrf2 activator derivatives for treating Parkinson disease
- The anti-inflammatory activities of twelve Nigerian medicinal plants: Inhibition of NfkB, activation of Nrf2, and antioxidant content
- L-carnitine mitigates bisphenol A-induced hepatic toxicity via activation of Nrf2 and inhibition of pro-inflammatory cytokine gene expression in rats
- Correction to: novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy
- Nicotinamide adenine dinucleotide attenuates acetaminophen-induced acute liver injury via activation of PARP1, Sirt1, and Nrf2 in mice
- … against pyroptosis to attenuate sevoflurane inhalation-induced post-operative cognitive dysfunction in rats via activation of HTR2A/ERK/Nrf2 axis by targeting …
- In-silico study of Marselia crenata compounds as activator Keap1/Nrf2 pathway in ovarian function
- Fucoxanthin suppresses OxLDL-induced inflammation via activation of Nrf2 and inhibition of NF-κB signaling
- Docosahexaenoic acid induces expression of NAD (P) H: quinone oxidoreductase and heme oxygenase-1 through activation of Nrf2 in cerulein-stimulated pancreatic …
- Sikyungbanha-Tang suppressing acute lung injury in mice is related to the activation of Nrf2 and TNFAIP3
- Design, Synthesis and Pharmacological Evaluation of N‐Benzyl Linoleamide Analogues from Tropaeolum tuberosum as NF‐κB Inhibitors and Nrf2 Activators
- Activation of the Nrf2/GPX4 Signaling by Pratensein From Trifolium pretense Mitigates Ferroptosis in OGD/R-Insulted H9c2 Cardiomyocytes
- Phytochemical Nrf2 activator attenuates skeletal muscle mitochondrial dysfunction and impaired proteostasis in a preclinical model of musculoskeletal aging
- Nrf2 Activation Improves Mitochondrial Function in Kidneys of Aged F344 Rats
- MEF2D upregulation protects neurons from oxygen–glucose deprivation/re-oxygenation-induced injury by enhancing Nrf2 activation
- Assessment and characterization of tomato lipophilic electrophiles and their potential contribution to nutraceutical properties via SKN-1/Nrf2 signaling activation
- SOCS3-mediated activation of p53-p21-NRF2 axis and cellular adaptation to oxidative stress in SOCS1-deficient hepatocellular carcinoma
- … attenuated oxidative stress-induced cellular damage in ARPE-19 human retinal pigment epithelial cells through Nrf2-mediated activation of heme oxygenase …
- Analogs of imine resveratrol alleviate oxidative stress‐induced neurotoxicity in PC12 cells via activation of Nrf2
- 5-Methyltetrahydrofolate Attenuates Oxidative Stress and Improves Kidney Function in Acute Kidney Injury through Activation of Nrf2 and Antioxidant Defense
- The Temporal and Contextual Relationship of NRF2 Activation and Cancer
- … neuronal derangements and kidney disturbances in streptozotocin-induced diabetic nephropathy via concomitant activation of Nrf2/Bcl-2/antioxidants axis
- IL-20R Activation via rIL-19 Enhances Hematoma Resolution through the IL-20R1/ERK/Nrf2 Pathway in an Experimental GMH Rat Pup Model
- NRF2/HO-1 pathway activation by ATF3 in a noise-induced hearing loss murine model
- Identification of novel and potent Nrf2 activators from medicinal plants
- … from Salicornia herbacea L. on Lipopolysaccharide-Stimulated Murine Macrophage via NF-kB and MAPK Inhibition and Nrf2/HO-1 Signaling Activation
- Protection Against Post-resuscitation Acute Kidney Injury by N-Acetylcysteine via Activation of the Nrf2/HO-1 Pathway
- RTA‐408 protects against propofol‐induced cognitive impairment in neonatal mice via the activation of Nrf2 and the inhibition of NF‐κB p65 nuclear translocation
- Neuroprotective Effect of WYY026B on Cerebral Ischemia/Reperfusion Injury in Rodents Through Activation of Nrf2/HO-1 Pathway
- Knockdown of IL-32 protects PC12 cells against oxygen-glucose deprivation/reoxygenation-induced injury via activation of Nrf2/NF-κB pathway
- … peptide protects vertebral endplate chondrocytes against H2O2‑induced apoptosis and oxidative stress through activation of the Nrf2/HO‑1 signaling …
- Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis
- Petatewalide B alleviates oxygen‑glucose deprivation/reoxygenation‑induced neuronal injury via activation of the AMPK/Nrf2 signaling pathway
- Tiron alleviates MPTP‐induced Parkinsonism in mice via activation of Keap‐1/Nrf2 pathway
- Evodiamine attenuates cadmium-induced nephrotoxicity through activation of Nrf2/HO-1 pathway
- Activation of nrf2/NQO1 pathway attenuates oxidative stress in neuronal cells induced by microwave and protects neurite development
- … ) phenyl) furan-2-carboxamide (BK3C231) induces cytoprotection in CCD18-Co human colon fibroblast cells through Nrf2/ARE pathway activation
- Elevation of chemosensitivity of lung adenocarcinoma a549 spheroid cells by Claudin-2 knockdown through activation of glucose transport and inhibition of Nrf2 …
- trans-Cinnamaldehyde prevents oxidative stress-induced apoptosis in V79-4 Chinese hamster lung fibroblasts through the Nrf2-mediated HO-1 activation
- Review on role of nrf2 pathway activation in neurological disorder
- n-3 Polyunsaturated fatty acid-enriched phosphatidylglycerol suppresses inflammation in RAW264. 7 cells through Nrf2 activation via alteration of fatty acids in cellular …
- Opioid-sparing Effects of the Nrf2 Activator Diroximel Fumarate in Mice
- … EFFECTS OF ISOLIQUIRITIN ON BEAS-2B CELLS AGAINST LPS-INDUCED OXIDATIVE STRESS AND INFLAMMATION INVOLVING ACTIVATION OF NRF2
- Keap1-Nrf2 signaling activation by Bardoxolone-methyl ameliorates high glucose-induced oxidative injury in human umbilical vein endothelial cells
- Molecular hydrogen protects against oxidative stress-induced RAW 264.7 macrophage cells through the activation of Nrf2 and inhibition of MAPK signaling pathway
- Costunolide Protects Myocardial from Ischemia Reperfusion Injury through Nrf2 Activation
- Modulation of Nrf2 by activation of estrogen receptor β as a therapeutic strategy to prevent cancer development and overcome inflammation-related drug resistance in …
- NRF2 Activation by KEAP1 Inhibition Induces Fetal Hemoglobin and Regulates Antioxidant Response in Erythroid Cells
- Bdh1-Mediated βOHB Metabolism Ameliorates Diabetic Kidney Disease by Activation of Nrf2-Mediated Antioxidative Pathway
- Anti-Inflammatory and Anti-Oxidant Effects of Epilobium amurense subsp. cephalostigma via Activation of Nrf2/HO-1 and Inhibition of NF-κB/p38 MAPK …
- Activation of intracellular antioxidant master gene Nrf2 by the extracts of Garcinia subelliptica, Ocimum gratissimum L., and Plectranthus ornatus
- 15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells
- Oxidative Stress and Nrf2 Activation in Dogs
- Activation of the Keap1-Nrf2 pathway by specioside and the n-butanol extract from the inner bark of Tabebuia rosea (Bertol) DC
- Correction to: novel biphenyl diester derivative AB-38b inhibits NLRP3 inflammasome through Nrf2 activation in diabetic nephropathy.
- Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling
- Ellagic Acid Protects from Rotenone-Induced Dopaminergic Neuronal Damage via Activation of Nrf2 Signaling in Astroglia
- Activation of NRF2 Pathways in Glaucoma
- Rosiglitazone ameliorates acute hepatic injury via activating the Nrf2 signaling pathway and inhibiting activation of the NLRP3 inflammasome
- Activation of α7 nicotinic acetylcholine receptor by its selective agonist improved learning and memory of amyloid precursor protein/presenilin 1 (APP/PS1) …
- Arsenite induces tissue factor synthesis through Nrf2 activation in cultured human aortic smooth muscle cells
- Nuclear factor erythroid 2-related factor 2 (NRF2) is a negative regulator of tissue plasminogen activator synthesis in cultured human vascular endothelial EA. hy926 …
- Research Article Nrf2 Activation Mediates Antiallodynic Effect of Electroacupuncture on a Rat Model of Complex Regional Pain Syndrome Type-I through …
- High Glucose Enhances Skin Sensitizer-induced NRF2 Activation In Vitro
- The Impact of the NRF2 Activators Arsenic Trioxide and Tert Butylhydroquinone on B Cell Function
- The Keap1/Nrf2/ARE system activators do not increase cardiac resistance to long-term ischemia/reperfu-sion
- … (Mertens) Kuntze Prevents Oxidative Stress-Induced Cellular Damage in V79-4 Chinese Hamster Lung Fibroblasts through the Activation of the Nrf2/HO-1 Signaling …
- Modulators of Nrf2 Activation During Inflammation
- Apigenin exerts chemopreventive effects on lung injury induced by SiO2 nanoparticles through the activation of Nrf2
- ANTIOXIDANT EFFECT OF SPINACH EXTRACT IN LIVER FIBROGENESIS ASSOCIATED TO ACTIVATION OF NRF2/HO-1 IN HYPERGLYCEMIC RATS
- The Role of Car and Nrf2 Dual Activation in Doxorubicin/Cyclophosphamide-Based Treatment of Triple Negative Breast Cancer
- Clinical Research Progress of NRF2 Activators in the Treatment of Age-related Diseases
- Inhibition of sphingomyelin synthase 2 relieves hypoxia-induced cardiomyocyte injury by reinforcing Nrf2/ARE activation via modulation of GSK-3β
- TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal …
- Eriodictyol ameliorated cognitive dysfunction in APP/PS1 mice through inhibited ferroptosis via vitamin D receptor mediated Nrf2 activation
- Extracts and Steroids from the Edible Mushroom Hypholoma lateritium Exhibit Anti‐Inflammatory Properties by Inhibition of COX‐2 and Activation of Nrf2
- Small Molecules for NRF2 Activation and Analytical Techniques to Visualize Cell Permeability
- Nrf2 Activator PB125® as a Potential Therapeutic
- Spinosin Attenuates Osteoclastogenesis through Suppressing NF-Κb by the Activation of Nrf2/HO-1 Signaling in Osteoporosis
- Could targeting miRNA-142-5p be a therapeutic strategy against COVID-19 through activation of the anti-inflammatory Nrf2/Keap1 pathway?
- Aloperine attenuates high glucose-induced oxidative injury in Schwann cells via activation of NRF2/HO-1 pathway
- Nutraceutical Activation of the Transcription Factor Nrf2 as a Potential Approach for Modulation of Aging
- The modulatory effects of Nrf2 activators in a pulmonary arterial hypertension model
- Modulatory Effects of Cilostazol; an Nrf2/HO-1 activator against NAFLD in Rats Confirmed by Molecular Docking and FTIR Studies
- Hesperetin protects SH-SY5Y cells against 6-hydroxydopamine-induced neurotoxicity via activation of NRF2/ARE signaling pathways
- Impact of the NRF2 activator, stabilised synthetic sulforaphane, on systemic inflammation in COVID19: results from the STAR-COVID19 trial
- Dexmedetomidine alleviates inflammation-induced neuropathic pain by suppressing NLRP3 via activation of Nrf2
- Therapeutic potential of oxymatrine in impeding the cardiomyopathy in the STZ-nicotinamide induced diabetes through SIRT1/Nrf2 signaling activation
- Polysaccharide From Laminaria Japonica Attenuates Radiation-Induced Xerostomia In Mice Via Activation of Nrf2 Signaling Pathway
- Neuroprotective Effects of Rhynchophylline Against Aβ1–42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2–ARE Activation
- Compensatory Activation of Nrf2 in Endothelial Cells inhibits Atherosclerosis through Limiting Inflammation and Lipid Peroxidation
- The effects of Nrf2 activators and oxidative stress on COPD alveolar macrophages
- Elucidation of the respective roles of itaconate and nitric oxide in the nuclear accumulation and activation of Nrf2 in activated macrophages
- Kaurenoic acid, a natural substance from traditional herbal medicine, alleviates palmitate induced hepatic lipid accumulation via Nrf2 activation
- Sulfiredoxin-1 inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration by enhancing the activation of Nrf2/ARE signaling
- … attenuates secondary brain injury following intracerebral hemorrhage by inhibiting NLRP3 inflammasome activation and promoting Nrf2/ARE signaling pathway in …
- Targeting Skeletal Muscle Mitochondrial Function with a Nrf2 Activator in a Novel Model of Musculoskeletal Decline
- Toxicity of new monophenolic synthetic activator of Keap1/Nrf2/ARE redox-sensitive signaling system in vitro and in vivo
- The Role of Nrf2 Activation on the Murine T Cell Response to Influenza Infection
- Maslinic Acid Alleviates Atherosclerosis by Suppressing Mitochondrial ROS-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 …
- Intraperitoneal injection of Nrf2 activator inhibited calvarial bone destruction in mice
- Nrf2 activator-encapsulating polymeric nanoparticles and LDL-like nanoparticles target atherosclerotic plaque
- Author Correction: Moderate Nrf2 Activation by Genetic Disruption of Keap1 Has Sex-Specific Effects on Bone Mass in Mice
- IMR-261, a Novel Oral Nrf2 Activator, Induces Fetal Hemoglobin in Human Erythroblasts, Reduces VOCs, and Ameliorates Ineffective Erythropoiesis in …
- deprivation/reoxygenation‑induced neuronal injury via activation of the AMPK/Nrf2 signaling pathway
- AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis
- Activation of NRF2/HO-1 Pathway by aqueous methanolic leaf extract of Triclisia gilletii and selected identified compounds in Triclisia gilletii, modulates crystal …
- … inflammatory mediator effects in LPS-induced macrophage and microglial cells by regulating BACH1 and HO-1/Nrf2 signals through inhibition of TLR4 activation
- To each their own: Disparate abilities of Nrf2 activators to protect against various electrophilic and oxidative insults
- Pathological Analyses in Constitutive Nrf2 Activation in The Liver
- Antioxidant status of blood plasma of acutely psychotic patients and its correlation with Nrf2 activation
- Activation of Nrf2‐mediated protective pathways by nature‐inspired hybrids improves proteostasis in retinal pigment epithelial cells
- Correction to: Nrf2 activation through the PI3K/GSK-3 axisprotects neuronal cells from Aβ-mediatedoxidative and metabolic damage
- Repurposing dimethyl fumarate? In vitro evidence of Nrf2‐pathway activation and cytoprotective effects in human retinal endothelial cells
- Evaluation of antioxidant activation by potential nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Keap1 complex inhibitors
- Z-ligustilide reduces cisplatin-induced nephrotoxicity via activation of NRF2/HO-1 signaling pathways
- Nrf2 activator Sulforaphane attenuates maternal adiposity and hepatic steatosis
- 391-P: The Nrf2 Activator Increases TFAM and Suppresses STING in Human Renal Proximal Tubular Cells
- Activation of Nrf2 By Genetic Alteration of Keap1 Confers Resistance to Chemotherapy in Head and Neck Squamous Carcinoma
- Correction: The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory …
- Anti-Inflammatory and Antioxidant Effects of Epilobium Amurense Subsp. Cephalostigma (Hausskn.) CJ Chen, Hoch & PH Raven via Activation of Nrf2/HO-1 and …
- TRIB3 promotes lung cancer cell survival and inhibits apoptosis through NRF2 activation
- Corrigendum to “Maggot Extracts Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis via the Activation of Nrf2”
- Possibility of NRF2 Activation as a Priming Tool Against SARS-COV-2 Infection
- Cancer cachexia‐mediated regulation of EcSOD synthesis requires Nrf2 activation by p62 phosphorylation
- Activation of Nrf2 Fails to Protect from Ischemia-reperfusion Cardiac Injury
- Activation of Nrf2/ARE signal pathway reduces radiotherapy-induced tissue injury
- Nrf2 activator relieves pulmonary vascular remodeling in rats with hypoxic pulmonary arterial hypertension
- Tetramethylpyrazine nitrone exerts neuroprotection via PGC-1α/Nrf2 activation and α-synuclein clearance in Parkinson’s disease models
- Therapeutic Nrf2 Activation improves LV function in the cardiomyocyte‐specific GPER knockdown mouse
- P1560: IMR-261, A NOVEL, ORAL NRF2 ACTIVATOR, REDUCES IRON OVERLOAD IN AN EXPERIMENTAL MOUSE MODEL BY ACTIVATING BMP6-MEDIATED …
- The Role of Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) in Preventing Inflammasome Activation in Peripheral Nerve Injury
- Activation of Transcription Factor Nrf2 Ameliorates Age‐Associated Decline in Kidney Function
- Study on the mechanism underlying activation of Nrf2/SKN-1 and lifespan elongation in Caenorhabditis elegans by chlorogenic acid
- Activation of NRF2 Blocks HIV Replication and Apoptosis in Macrophages
- Activation of Nrf2 at Critical Windows of Development Alters Protein S-Glutathionylation in the Zebrafish Embryo (Danio rerio)
- The cadmium altered oxidative homeostasis leads to energetic metabolism rearrangement, Nrf2 activation with increased GSH production and reduced SOD1 activity …
- Publisher Correction: Extracellular Hsp90α stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative …
- Costunolide protects myocardium from ischemia reperfusion injury by inhibiting oxidative stress through Nrf2/Keap1 pathway activation
- Retraction Note: Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture
- Activation of NRF2 signaling accelerates development of small cell lung cancer in mice
- Protective Effect of Swertiamarin on Myocardial Injury Through Activation of Nrf2/HO-1 Pathway in Heart Failure Model of Rats.
- Corrigendum to” Probucol improves erectile function via activation of Nrf2 and coordinates the HO-1/DDAH/PPAR-γ/eNOS pathways in streptozotocin-induced diabetic …
- Fucoxanthin Attenuates Aβ-Induced Oxidative Stress via Akt/GSK-3β/Fyn-mediated Nrf2 Activation
- Constitutive activation of Nrf2 antioxidant pathway leads to age-dependent goiter and compensated hypothyroidism in mice
- Blue Mussel-derived Peptides Lead to Activation of Nrf2 and HO-1 Signaling Pathway to Alleviate H₂O₂-induced HUVEC Damage
- Cytoprotective effects of fermented oyster extracts against oxidative stress-induced DNA damage and apoptosis through activation of the Nrf2/HO-1 signaling …
- … of (-)-Linalool,(-)-Borneol and Trans-Caryophyllene Inhibits Inflammation and Apoptosis Through Suppression of NF-κB and Activation of Nrf2/HO-1 Signaling …
- Protective effects of fermented oyster extracts against oxidative stress-induced-DNA damage and apoptosis through activation of the Nrf2/HO-1 signaling pathway in …
- OR28-01 Constitutive Activation of NRF2 Antioxidant Response Leads to Age-Dependent Goiter and Compensated Hypothyroidism in Male Mice
- … Via Suppression of Oxidative Stress-Associated Txnip and Peroxynitrite-Dominated Nlrp3 Inflammasome Activation by Motivating the Nrf2 Pathway after Subarachnoid …
- CKIP-1 participates in the activation of Nrf2 signaling pathway by Cx43 and the regulation of diabetic renal fibrosis
- … oxygen‑glucose deprivation/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/Nrf2 signaling pathway in human …
- Protective effects of naringin phospholipid complex on oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway
- p62 promotes HIV-1 gp120 V3 loop-mediated microglial inflammation by promoting noncanonical activation of Nrf2
- … AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl₄: roles in the activation of the Nrf2 cascade and subsequent …
- Lycopene Induces Expression of NAD (P) H Quinone Oxidoreductase and Heme Oxygenase-1 through Activation of Nrf2 in Ethanol/LPS-stimulated Pancreatic Acinar …
- … the secretion of IL‐8 in retinal pigment epithelial cells suffering from mitochondrial dysfunction via activation of nuclear factor erythroid 2 related factor 2 (NFE2L2/Nrf2)
- Action dichotomique du cinnamaldehyde dans l’activation des kératinocytes: un rôle à jouer pour Nrf2?
- Eudesmanolide from Salvia plebeia Protects H9c2 Cardiomyocytes Against Hypoxia/Reoxygenation-Induced Apoptosis with Nrf2 Activation
- Isoliquiritigenin inhibits Oxidative Stress and Inflamamtion in LPS-Induced BEAS-2B Cells Involving Nrf2 Activation
- 3-NP-induced Huntington’s-like disease impairs Nrf2 activation without loss of cardiac function in aged rats
- Human papillomavirus 16 E7 promotes EGFR/PI3K/AKT1/NRF2 signaling pathway contributing to PIR/NF-κB activation in oral cancer cells
- NRF2 Activation by Nitrogen Heterocycles: A Review
- An updated patent review of Nrf2 activators (2020-present)
- Activators of Nrf2 to Counteract Neurodegenerative Diseases
- NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer
- NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease
- LncRNA MHRT Prevents Angiotensin II-Induced Myocardial Oxidative Stress and NLRP3 Inflammasome via Nrf2 Activation
- Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting …
- A comprehensive and mechanistic review on protective effects of kaempferol against natural and chemical toxins: Role of NF‐κB inhibition and Nrf2 activation
- Olive oil promotes the survival and migration of dermal fibroblasts through Nrf2 pathway activation
- N‐Acetylserotonin is an oxidation‐responsive activator of Nrf2 ameliorating colitis in rats
- The Multi-Faceted Consequences of NRF2 Activation throughout Carcinogenesis
- Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator for the antioxidant and anti-inflammatory effects
- Activation of NRF2 blocks HIV replication and apoptosis in macrophages
- Phenylsulfonimide PPARα Antagonists Enhance Nrf2 Activation and Promote Oxidative Stress-Induced Apoptosis/Pyroptosis in MCF7 Breast Cancer Cells
- Omaveloxolone: an activator of Nrf2 for the treatment of Friedreich ataxia
- Estradiol protects hair cells from cisplatin-induced ototoxicity via Nrf2 activation
- Simultaneous Elimination of Reactive Oxygen Species and Activation of Nrf2 by Ultrasmall Nanoparticles to Relieve Acute Kidney Injury
- Nrf2 Activation Does Not Protect from Aldosterone-Induced Kidney Damage in Mice
- Synthesis of New Shogaol Analogues as NRF2 Activators and Evaluation of Their Anti-Inflammatory Activity, Modes of Action and Metabolic Stability
- Nrf2 and its dependent autophagy activation cooperatively counteract ferroptosis to alleviate acute liver injury
- Metformin suppresses oxidative stress induced by high glucose via activation of the Nrf2/HO-1 signaling pathway in type 2 diabetic osteoporosis
- Identification of NRF2 Activation as a Prognostic Biomarker in T-Cell Acute Lymphoblastic Leukaemia
- Phytochemical activators of Nrf2: a review of therapeutic strategies in diabetes: Phytochemical activators of Nrf2
- CD4+ T Cell NRF2 Signaling Improves Liver Transplantation Outcomes by Modulating T Cell Activation and Differentiation
- Developmental impacts of Nrf2 activation by dimethyl fumarate (DMF) in the developing zebrafish (Danio rerio) embryo
- Quercetin and resveratrol inhibit ferroptosis independently of Nrf2–ARE activation in mouse hippocampal HT22 cells
- Carnosic acid mitigates depression-like behavior in ovariectomized mice via activation of Nrf2/HO-1 pathway
- Decrease in cholesterol in the cell membrane is essential for Nrf2 activation by quercetin
- β-patchoulene alleviates cognitive dysfunction in a mouse model of sepsis associated encephalopathy by inhibition of microglia activation through Sirt1/Nrf2 …
- Genistein and Procyanidin B2 Reduce Carcinogen-Induced Reactive Oxygen Species and DNA Damage through the Activation of Nrf2/ARE Cell Signaling in …
- Lycopene ameliorates aflatoxin B1-induced testicular lesion by attenuating oxidative stress and mitochondrial damage with Nrf2 activation in mice
- The Triterpenoid Nrf2 Activator, CDDO-Me, Decreases Neutrophil Senescence in a Murine Model of Joint Damage
- SOCS1 Deficiency Promotes Hepatocellular Carcinoma via SOCS3-Dependent CDKN1A Induction and NRF2 Activation
- Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2/GPX4 axis in SAMP8 mice
- Methyl eugenol protects the kidney from oxidative damage in mice by blocking the Nrf2 nuclear export signal through activation of the AMPK/GSK3β axis
- … tanshinone IIA sulfonate protects against hyperhomocysteine-induced vascular endothelial injury via activation of NNMT/SIRT1-mediated NRF2/HO-1 and …
- Nrf2-mediated activation of HO-1 is required in the blocking effect of compound K, a ginseng saponin metabolite, against oxidative stress damage in ARPE-19 …
- … abrogates the protective effects of liraglutide on ischaemic stroke via inhibition of M2 polarisation and activation of NLRP3 inflammasome by reducing Nrf2 activation
- S-allylmercapto-N-acetylcysteine ameliorates pulmonary fibrosis in mice via Nrf2 pathway activation and NF-κB, TGF-β1/Smad2/3 pathway suppression
- Enhanced liquidity of p62 droplets mediated by Smurf1 links Nrf2 activation and autophagy
- … from steam‐processed Polygonatum cyrtonema Hua protect against d‐galactose‐induced oxidative damage in mice by activation of Nrf2/HO‐1 signaling
- Irisin attenuates ethanol-induced behavioral deficits in mice through activation of Nrf2 and inhibition of NF-κB pathways
- Antioxidant and Anti-Inflammatory Mechanisms of Cardamonin through Nrf2 Activation and NF-kB Suppression in LPS-Activated BV-2 Microglial Cells
- The Role of Fucoxanthin as a Potent Nrf2 Activator via Akt/GSK-3β/Fyn Axis against Amyloid-β Peptide-Induced Oxidative Damage
- A homogeneous Lonicera japonica polysaccharide alleviates atopic dermatitis by promoting Nrf2 activation and NLRP3 inflammasome degradation via p62
- Mangiferin protects DNase 2 abundance via Nrf2 activation to prevent cytosolic mtDNA accumulation during liver injury
- Hesperetin ameliorates spinal cord injury by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling
- Choline and trimethylamine N-oxide impair metabolic activation of and platelet response to clopidogrel through activation of the NOX/ROS/Nrf2/CES1 pathway
- The preventive effect of Mori Ramulus on oxidative stress-induced cellular damage in skeletal L6 myoblasts through Nrf2-mediated activation of HO-1
- Pterostilbene attenuates hemin-induced dysregulation of macrophage M2 polarization via Nrf2 activation in experimental hyperglycemia
- CRISPR/Cas9-Based Screening of FDA-Approved Drugs for NRF2 Activation: A Novel Approach to Discover Therapeutics for Non-Alcoholic Fatty Liver …
- NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1G93A mutation and exerts neuroprotection in amyotrophic lateral sclerosis
- Melatonin attenuates bisphenol A-induced colon injury by dual targeting mitochondrial dynamics and Nrf2 antioxidant system via activation of SIRT1/PGC-1α signaling …
- Suppression of MAPK/NF‐kB and activation of Nrf2 signaling by Ajugarin‐I in EAE model of multiple sclerosis
- … protects against oleic acid-triggered mitochondrial dysfunction to relieve oxidative stress and inflammation via activation of the AMPK-Nrf2 axis by targeting GPR30 in …
- 17β-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation
- … inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1‐mediated Nrf2/HO‐1 activation
- … ameliorates carbon tetrachloride-induced acute liver injury via the inhibition of oxidative stress, NF-κB pathways, and the activation of Nrf2/HO-1 pathway
- … chronic restraint stress aggravated DSS-induced ulcerative colitis in mice via inhibition of NF-κB/STAT3 and activation of HO-1/Nrf2/SIRT1 signaling pathways
- The anti-inflammatory and anti-oxidative effect of a classical hypnotic bromovalerylurea mediated by the activation of NRF2
- Kaempferol ameliorates palmitate-induced lipid accumulation in HepG2 cells through activation of the Nrf2 signaling pathway
- Sarmentosin induces autophagy-dependent apoptosis via activation of Nrf2 in hepatocellular carcinoma
- Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress
- Involvement of the inhibition of mitochondrial apoptotic, p53, NF-κB pathways and the activation of Nrf2/HO-1 pathway in the protective effects of curcumin …
- Dimethyl fumarate‐mediated Nrf2/ARE pathway activation and glibenclamide‐mediated NLRP3 inflammasome cascade inhibition alleviate type II diabetes …
- Differential Activation of NRF2 Signaling Pathway in Renal-Cell Carcinoma Caki Cell Lines
- Indian traditional rice variety “Gathuwan” suppresses T-cell-mediated immune responses via activation of ERK/Nrf2/HO-1 signalling pathway
- PD184352 exerts anti-inflammatory and antioxidant effects by promoting activation of the Nrf2/HO-1 axis
- SESN2-mediated AKT/GSK-3β/NRF2 Activation to Ameliorate Adriamycin Cardiotoxicity in High Fat Diet-induced Obese Mice
- Cytoprotective Effect of Pteryxin on Insulinoma MIN6 Cells Due to Antioxidant Enzymes Expression via Nrf2/ARE Activation
- Activation of Nrf2 signaling by 4-octyl itaconate attenuates the cartilaginous endplate degeneration by inhibiting E3 ubiquitin ligase ZNF598
- Pharmacological activation of the Nrf2 pathway by Taxifolin remodels articular cartilage microenvironment for the therapy of Osteoarthritis
- Copper induces liver lipotoxicity disease by up-regulating Nrf2 expression via the activation of MTF-1 and inhibition of SP1/Fyn pathway
- … zinc alleviates tert-butyl hydroperoxide-induced mitochondrial oxidative stress on embryonic development involving the activation of Nrf2/PGC-1α pathway
- Lycopene attenuates chlorpyrifos-induced hepatotoxicity in rats via activation of Nrf2/HO-1 axis
- Nrf2 regulates the activation of THP-1 cells induced by chloral hydrate
- Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARγ and Nrf2 signaling
- Sestrin2 provides cerebral protection through activation of Nrf2 signaling in microglia following subarachnoid hemorrhage
- The inhibitory effect of vitamin D on myocardial homocysteine levels involves activation of Nrf2-mediated methionine synthase
- Omentin-1 ameliorates experimental inflammatory bowel disease via Nrf2 activation and redox regulation
- Photobiomodulation Controls Keratinocytes Inflammatory Response through Nrf2 and Reduces Langerhans Cells Activation
- Osthole Antagonizes Microglial Activation in an NRF2-Dependent Manner
- … effects of different doses of selenium against fluoride-triggered apoptosis and oxidative stress-mediated renal injury in rats through the activation of Nrf2/HO-1/NQO1 …
- Bisphenol A-induced autophagy ameliorates human B cell death through Nrf2-mediated regulation of Atg7 and Beclin1 expression by Syk activation
- Phytochemicals to regulate oxidative and electrophilic stress through Nrf2 activation
- Knockdown of PHLDA1 alleviates necrotizing enterocolitis by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling
- Samarcandin protects against testicular ischemia/reperfusion injury in rats via activation of Nrf2/HO-1-mediated antioxidant responses
- Activation of Nrf2 pathway as a protective mechanism against oxidative stress-induced diseases: Potential of astaxanthin
- Selenomethionine attenuates ochratoxin A-induced small intestinal injury in rabbits by activating the Nrf2 pathway and inhibiting NF-κB activation
- Astragaloside IV attenuates high glucose‐induced NF‐κB‐mediated inflammation through activation of PI3K/AKT‐ERK‐dependent Nrf2/ARE signaling pathway in …
- AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
- Bioactive compounds in Layacha brown rice (Oryza sativa L.) improve immune responses in mice via activation of transcription factor Nrf2
- H2S Alleviates Neuropathic Pain in Mice by Nrf2 Signaling Pathway Activation
- … selenite preserves rBM-MSCs’ stemness, differentiation potential, and immunophenotype and protects them against oxidative stress via activation of the Nrf2 …
- MitoQ alleviates triptolide-induced cardiotoxicity via activation of p62/Nrf2 axis in H9c2 cells
- PPAR-γ Activation Alleviates Osteoarthritis through Both the Nrf2/NLRP3 and PGC-1α/Δψm Pathways by Inhibiting Pyroptosis
- Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation
- Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis
- Farnesol exerts protective effects against chronic sleep deprivation‐induced cognitive impairment via activation SIRT1/Nrf2 pathway in the hippocampi of adult mice
- Suppression of neuronal apoptosis and glial activation with modulation of Nrf2/HO-1 and NF-kB signaling by curcumin in streptozotocin-induced diabetic …
- A Preclinical Model for Parkinson’s Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies
- Chemoprevention of lotus leaf ethanolic extract through epigenetic activation of the NRF2-mediated pathway in murine skin JB6 P+ cell neoplastic …
- Hydroxy-Selenomethionine Mitigated Chronic Heat Stress-Induced Porcine Splenic Damage via Activation of Nrf2/Keap1 Signal and Suppression of NFκb …
- … effects of bavachin against neuroinflammation and oxidative stress-induced neuronal damage via activation of Sirt1/Nrf2 pathway and inhibition of NF-κB …
- BRG1 alleviates microglial activation by promoting the KEAP1-NRF2/HO-1 signaling pathway and minimizing oxidative damage in cerebral ischemia–reperfusion
- Melatonin attenuates high glucose‑induced endothelial cell pyroptosis by activating the Nrf2 pathway to inhibit NLRP3 inflammasome activation
- Saikosaponin A and D attenuate skeletal muscle atrophy in chronic kidney disease by reducing oxidative stress through activation of PI3K/AKT/Nrf2 pathway
- Activation of α7nAChR by PNU282987 improves cognitive impairment through inhibiting oxidative stress and neuroinflammation in D-galactose induced …
- Nrf2 Is Involved in Hyperglycemia-Induced Abnormal Lung Development Through Both Antioxidation-Dependent and Antioxidation-Independent Activation
- Parthenolide Phytosomes Attenuated Gentamicin-Induced Nephrotoxicity in Rats via Activation of Sirt-1, Nrf2, OH-1, and NQO1 Axis
- 6-Formylindolo (3, 2-b) carbazole Dampens Inflammation and Reduces Endotoxin-Induced Kidney Injury via Nrf2 Activation
- Acylated ghrelin suppresses doxorubicin-induced testicular damage and improves sperm parameters in rats via activation of Nrf2 and mammalian target of rapamycin
- Polyphyllin I induces apoptosis and autophagy in temozolomide-resistant glioma via modulation of NRF2 and MAPK-signaling activation
- NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner
- … cerebral neurotoxicity by activating Nrf2 and suppressing redox cycle imbalance, inflammatory iNOS/NO/NF-κB response and caspase-3/Bax activation in rats
- Lipoxin A4 attenuated dexamethasone-induced muscle atrophy via activation of PGC-1α/Nrf2/TFAM pathway
- Antioxidative effect of Periplaneta americana extract on dextran sulfate sodium-induced ulcerative colitis through activation of the Nrf2 signal
- Dopamine D1 receptor activation ameliorates ox-LDL-induced endothelial cell senescence via CREB/Nrf2 pathway
- Baicalein Alleviates Arsenic-induced Oxidative Stress through Activation of the Keap1/Nrf2 Signalling Pathway in Normal Human Liver Cells
- … protein alleviates allodynia and improves Schwann cell function against diabetic peripheral neuropathy via activation of the Nrf2‐dependent antioxidant system and …
- Zn and Se abrogate heavy metal mixture induced ovarian and thyroid oxido-inflammatory effects mediated by activation of NRF2-HMOX-1 in female albino …
- δ-Opioid Receptor Activation Inhibits Ferroptosis by Activating the Nrf2 Pathway in MPTP-Induced Parkinson Disease Models
- Structural basis of Nrf2 activation by flavonolignans from silymarin
- Comments on “The ameliorative effect of kaempferol against CdCl2-mediated renal damage entails activation of Nrf2 and inhibition of NF-kB” by Alshehri Ali et al …
- Activation of Nrf2/HO-1 antioxidant signaling correlates with the preventive effect of loganin on oxidative injury in ARPE-19 human retinal pigment epithelial cells
- … Inhibits Oxidative Stress and NF-κB/NLRP3 Activation in Dextran Sulfate Sodium Salt-Induced Colitis in Mice with Involvement of the Nrf2 Signaling Pathway and …
- Salidroside attenuates LPS-induced kidney injury through activation of SIRT1/Nrf2 pathway
- Lung protective effects of dietary malate esters derivatives from Bletilla striata against SiO2 nanoparticles through activation of Nrf2 pathway
- Activation of the Cap’n’collar C pathway (Nrf2 pathway in vertebrates) signaling in insulin pathway compromised Drosophila melanogaster flies ameliorates the …
- Ferulic acid exerts a protective effect against cyclosporine‐induced liver injury in rats via activation of the Nrf2/HO‐1 signaling, suppression of oxidative stress …
- Activation of PPARγ prevents ferroptosis-induced damage through Nrf2/Gpx4 signaling pathway in rat hippocampus following epilepsy
- … metaplasia through NLR family pyrin domain-containing 3 (NLRP3)-mediated IL-33 activation via a reactive oxygen species (ROS)-NRF2-Heme oxygenase-1 (HO-1) …
- Activation of the Keap1/Nrf2 Pathway as an Adaptive Response to an Electrophilic Metabolite of Morphine
- NRF2 activation in the heart induces glucose metabolic reprogramming and mediates cardioprotection via upregulation of the pentose phosphate pathway.
- Resolvin D1/N-formyl peptide receptor 2 ameliorates paclitaxel-induced neuropathic pain through the activation of IL-10/Nrf2/HO-1 pathway in mice
- 6-Gingerol attenuates sepsis-induced acute lung injury by suppressing NLRP3 inflammasome through Nrf2 activation
- Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation
- Succinylation of a KEAP1 sensor lysine promotes NRF2 activation
- … Hepatocytes-Derived Extracellular Vesicles Ameliorated Liver Fibrosis in Mice via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2/HO-1 Signaling
- Targeted activation of Nrf2/HO‐1 pathway by Corynoline alleviates osteoporosis development
- P235 Pharmacological activation of NRF2 has protective effects during Mycobacterium abscessus infection by promoting host defences and reducing inflammatory …
- The Role of Nrf2 Activation and Autophagy in Aging and Neurodegenerative Diseases
- Mountain-cultivated ginseng protects against cognitive impairments in aged GPx-1 knockout mice via activation of Nrf2/ChAT/ERK signaling pathway
- Activation of the NLRP3 inflammasome by HMGB1 through inhibition of the Nrf2/HO-1 pathway promotes bleomycin-induced pulmonary fibrosis after acute lung injury …
- Phenolic compound SG-1 from Balanophora harlandii and its derivatives exert anti-influenza A virus activity via activation of the Nrf2/HO-1 pathway
- Baicalin Reduces Renal Inflammation in Mesangial Proliferative Glomerulonephritis through Activation of Nrf2/ARE and PI3K/AKT Pathways
- Inhibition of p62-Keap1-Nrf2 Pathway Activation by Realgar Promotes the Inhibition of Esophageal Cancer Cell Proliferation, Migration, and Ferroptosis
- CRISPR-Based Screening of FDA-Approved Drugs for NRF2 Activation: A Novel Approach to Discover Therapeutics for Non-Alcoholic Fatty Liver Disease
- Two Weeks of Nrf2 Activation Improves Maximal Mitochondrial Respiration in Older Adults with Lower Starting Values
- Cannabinoid type 2 receptor activation inhibits MPP+-induced M1 differentiation of microglia through activating PI3K/Akt/Nrf2 signal pathway
- Flavonoids Activation of Nrf2 and Osteoporosis
- Role of Flavonoid Activation of Nrf2 in Neurodegenerative Disease and Brain Aging
- Balancing Nrf2 activation: A promising strategy for cancer treatment
- Bryostatin‐1 attenuates intestinal ischemia/reperfusion‐induced intestinal barrier dysfunction, inflammation, and oxidative stress via activation of Nrf2/HO‐1 signaling
- Reducing neurodegeneration and oxidative damage in Alzheimer’s disease: Role of the Nrf2 pathway activation by natural compounds
- Pirfenidone attenuates nonalcoholic fatty liver disease through activation of the nuclear factor erythroid 2‐related factor 2 (Nrf2) signaling pathway
- Protective effects of baicalin against L-glutamate-induced oxidative damage in HT-22 cells by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling
- Investigation into the Enhanced Activation of the ARE and the Correlations between NRF2 and Other Cytoprotective Pathways such as AHR, HSP, and Apoptosis
- The Nrf2 activator tBHQ promotes OVA-Elicited Food Allergy in Mice
- Lung-Targeted Delivery of Nrf2 Activators Promotes the Reversal of Age-Dependent Established Lung Fibrosis
- Effect of Dunaliella salina on myocardial ischemia-reperfusion injury through KEAP1/NRF2 pathway activation and JAK2/STAT3 pathway inhibition
- Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling
- Retraction notice to “Cadmium induced cardiac oxidative stress in rats and its attenuation by GSP through the activation of Nrf2 signaling pathway”[Chem. Biol. Interact …
- The reno-protective effect of celastrol mediated by Nrf2/HO-1 activation and NF-κB/NLRP3 suppression in hepatic ischemia/reperfusion model
- Activation of Nrf2 Pathway by Natural Products
- Activation of Nrf2 signaling pathway by Tectoridin protects against ferroptosis in particulate matter‐induced lung injury
- Activation of NRF2-mediated oxidative stress response pathway by curcumin analog FLLL12: Implication for chemoprevention
- Activation of Nrf2 by sulfuretin stimulates chondrocyte differentiation and increases bone lengths in zebrafish.
- Hidrosmin Attenuates Inflammatory Response Induced by IL1β by Suppressing the Activation of NF-κB Involving Nrf2/HO1 Pathway in Human Osteoarthritis …
- … myocardial infarction-induced cardiac fibrosis by targeting Keap1/Nrf2 to regulate oxidative stress and inhibit cardiac-fibroblast activation and proliferation”[Free Radic …
- Low-dose Naltrexone (LDN) extends healthspan and lifespan through activation of the transcription factor SKN-1/NRF2 in C. elegans.
- ACOD1 Facilitates p62-Mediated Keap1 Degradation for Nrf2 Activation to Reduce Neuroinflammation and Oxidative Stress Post Spinal Cord Contusion
- A computational study to identify Sesamol derivatives as NRF2 activator for protection against drug-induced liver injury (DILI)
- Diallyl disulfide blocks cigarette carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis via activation of Nrf2 antioxidant system and …
