LUNG CANCER (MEDICINAL PLANT PREVENTION)
December 8, 2023LIPOLYTIC AGENTS
December 8, 2023
- The biology of PGC-1α and its therapeutic potential
- PGC-1α: a key regulator of energy metabolism
- PGC-1α-mediated adaptations in skeletal muscle
- PGC-1α and PGC-1β regulate mitochondrial density in neurons
- Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells
- Multiple environmental and genetic factors influence skeletal muscle PGC-1α and PGC-1β gene expression in twins
- … PGC-1α) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-α and-γ: identification of novel leucine-rich interaction motif within PGC …
- Role of PGC‐1α signaling in skeletal muscle health and disease
- Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway
- PGC-1α: turbocharging mitochondria
- Impaired PGC-1α function in muscle in Huntington’s disease
- PGC-1α, a new therapeutic target in Huntington’s disease?
- PGC-1α in aging and anti-aging interventions
- PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity
- Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): transcriptional coactivator and metabolic regulator
- PGC-1α supports glutamine metabolism in breast cancer
- FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway
- Transcriptional coactivators PGC-1α and PGC-lβ control overlapping programs required for perinatal maturation of the heart
- Transcriptional control of mitochondrial biogenesis: the central role of PGC-1α
- … transcription of the peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) gene in skeletal muscle through the PGC-1α autoregulatory loop and …
- Activation of nuclear receptor coactivator PGC-1α by arginine methylation
- Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5
- Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
- PGC-1α, mitochondrial dysfunction, and Huntington’s disease
- Metabolic adaptations through the PGC-1α and SIRT1 pathways
- A fundamental system of cellular energy homeostasis regulated by PGC-1α
- PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells
- Sirtuin 3, a new target of PGC-1α, plays an important role in the suppression of ROS and mitochondrial biogenesis
- SUMOylation attenuates the function of PGC-1α
- A role for the transcriptional coactivator PGC-1α in muscle refueling
- Development of insulin resistance in mice lacking PGC-1α in adipose tissues
- The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis
- Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis
- Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
- Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor α (ERRα) ligand
- PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson’s disease
- Endothelial PGC-1α mediates vascular dysfunction in diabetes
- IRF4 is a key thermogenic transcriptional partner of PGC-1α
- PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy
- Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway
- PGC-1α expression decreases in the Alzheimer disease brain as a function of dementia
- The many roles of PGC-1α in muscle—recent developments
- The role of PGC-1α in the pathogenesis of neurodegenerative disorders
- The role of PGC-1α on mitochondrial function and apoptotic susceptibility in muscle
- Metformin induces PGC‐1α expression and selectively affects hepatic PGC‐1α functions
- PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells
- Re-evaluating the FOXO1–PGC-1α connection
- PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice
- Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR
- Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1α expression
- Exercise and adrenaline increase PGC‐1α mRNA expression in rat adipose tissue
- Transcriptional coactivator PGC-1α integrates the mammalian clock and energy metabolism
- PGC-1α at the crossroads of type 2 diabetes
- Decreased mRNA Expression of PGC-1α and PGC-1α-Regulated Factors in the SOD1G93A ALS Mouse Model and in Human Sporadic ALS
- HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
- Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines
- The transcriptional coactivator PGC-1α mediates exercise-induced angiogenesis in skeletal muscle
- PGC-1α and PGC-1β have both similar and distinct effects on myofiber switching toward an oxidative phenotype
- A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy
- Regulation of hypoxia-inducible genes by PGC-1α
- Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle
- Regulation of mitochondrial biogenesis and PGC-1α under cellular stress
- Suppression of β cell energy metabolism and insulin release by PGC-1α
- Mutual dependence of Foxo3a and PGC-1α in the induction of oxidative stress genes
- Isoform-specific increases in murine skeletal muscle peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) mRNA in response to β2-adrenergic …
- Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging
- AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
- Mitochondria and PGC-1α in aging and age-associated diseases
- Transcriptional repression of PGC-1α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
- Exercise stimulates PGC-1α transcription in skeletal muscle through activation of the p38 MAPK pathway
- PPARγ co-activator-1α (PGC-1α) reduces amyloid-β generation through a PPARγ-dependent mechanism
- PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
- The truncated splice variants, NT‐PGC‐1α and PGC‐1α4, increase with both endurance and resistance exercise in human skeletal muscle
- Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
- Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice
- Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1α
- PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types
- PGC-1α mediates exercise-induced skeletal muscle VEGF expression in mice
- Hypothalamic PGC-1α protects against high-fat diet exposure by regulating ERα
- Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial …
- Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
- Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle
- Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK
- An increase in murine skeletal muscle peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) mRNA in response to exercise is mediated by β …
- GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1α
- Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats
- AMP-activated protein kinase-regulated activation of the PGC-1α promoter in skeletal muscle cells
- PGC-1α rescues Huntington’s disease proteotoxicity by preventing oxidative stress and promoting TFEB function
- SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α
- PGC-1α: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes
- Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of …
- Interactions between ROS and AMP kinase activity in the regulation of PGC-1α transcription in skeletal muscle cells
- Rapid exercise-induced changes in PGC-1α mRNA and protein in human skeletal muscle
- Separation of the gluconeogenic and mitochondrial functions of PGC-1α through S6 kinase
- PGC-1α activates CYP7A1 and bile acid biosynthesis
- PGC-1α deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis
- Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
- PGC-1α regulates normal and pathological angiogenesis in the retina
- PGC-1α controls hepatitis B virus through nutritional signals
- A functional interaction between RIP140 and PGC-1α regulates the expression of the lipid droplet protein CIDEA
- Targeting PGC-1α to control energy homeostasis
- The gene coding for PGC-1α modifies age at onset in Huntington’s Disease
- Non-CpG methylation of the PGC-1α promoter through DNMT3B controls mitochondrial density
- Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
- Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
- PGC‐1α activation as a therapeutic approach in mitochondrial disease
- SCFCdc4 acts antagonistically to the PGC-1α transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis
- In vivo correction of COX deficiency by activation of the AMPK/PGC-1α axis
- The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex
- Acute endurance exercise increases the nuclear abundance of PGC-1α in trained human skeletal muscle
- mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex
- PGC-1α mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle
- SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex
- Mitochondrial biogenesis and peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) deacetylation by physical activity: intact adipocytokine signaling is …
- Exercise-induced PGC-1α transcriptional factors in skeletal muscle
- Nitric oxide and AMPK cooperatively regulate PGC‐1α in skeletal muscle cells
- PGC-1α, a key modulator of p53, promotes cell survival upon metabolic stress
- PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
- Roles of oxidative stress, apoptosis, PGC-1α and mitochondrial biogenesis in cerebral ischemia
- PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner
- The importance of PGC-1α in contractile activity-induced mitochondrial adaptations
- Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: a reevaluation
- PGC-1α buffers ROS-mediated removal of mitochondria during myogenesis
- PGC-1α is dispensable for exercise-induced mitochondrial biogenesis in skeletal muscle
- PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
- Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1α
- PGC-1α-mediated branched-chain amino acid metabolism in the skeletal muscle
- PGC-1α coactivates PDK4 gene expression via the orphan nuclear receptor ERRα: a mechanism for transcriptional control of muscle glucose metabolism
- Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
- Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
- PGC-1α-induced improvements in skeletal muscle metabolism and insulin sensitivity
- Dynamic regulation of PGC‐1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response
- PGC-1α is not mandatory for exercise-and training-induced adaptive gene responses in mouse skeletal muscle
- … rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1α gene transcription: an autoregulatory loop controls PGC-1α expression in adipocytes …
- Modular evolution of PGC-1α in vertebrates
- PGC-1α and ERRα target gene downregulation is a signature of the failing human heart
- Thermoregulatory and metabolic defects in Huntington’s disease transgenic mice implicate PGC-1α in Huntington’s disease neurodegeneration
- Effects of acute bouts of running and swimming exercise on PGC-1α protein expression in rat epitrochlearis and soleus muscle
- Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1α
- Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1α
- Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator
- … activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) deacetylation following endurance …
- Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease
- FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
- Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) …
- Diammonium Glycyrrhizinate Upregulates PGC-1α and Protects against Aβ1–42-Induced Neurotoxicity
- PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARγ-dependent pathway
- Parvalbumin deficiency and GABAergic dysfunction in mice lacking PGC-1α
- Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1α transcription and mitochondrial biogenesis in muscle cells
- PPARδ, but not PPARα, activates PGC-1α gene transcription in muscle
- Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
- PGC-1α and exercise in the control of body weight
- The role of nNOS and PGC-1α in skeletal muscle cells
- Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk
- The effects of acute and chronic exercise on PGC‐1α, irisin and browning of subcutaneous adipose tissue in humans
- Skeletal muscle-specific expression of PGC-1α-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake
- Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function
- PGC-1α over-expression promotes recovery from mitochondrial dysfunction and cell injury
- Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC‐1α
- FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
- Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals
- A PGC-1α-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose
- Exercise increases mitochondrial PGC-1α content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis
- Partnership of PGC-1α and HNF4α in the regulation of lipoprotein metabolism
- Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1α
- PGC-1α is required for exercise-and exercise training-induced UCP1 up-regulation in mouse white adipose tissue
- Transcriptional coactivator PGC-1α regulates chondrogenesis via association with Sox9
- Identification and characterization of an alternative promoter of the human PGC-1α gene
- Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice
- The orphan nuclear receptor SHP regulates PGC-1α expression and energy production in brown adipocytes
- Genome-wide coactivation analysis of PGC-1α identifies BAF60a as a regulator of hepatic lipid metabolism
- PGC-1α integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle
- Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training
- Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: role of PGC-1α
- PGC-1α regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload
- Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis
- Peroxisome proliferator‐activated receptor‐γ co‐activator‐1α (PGC‐1α) gene polymorphisms and their relationship to Type 2 diabetes in Asian Indians
- PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis
- Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1α: regulation by SUMOylation and oxidation
- Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch
- O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability
- Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1α
- Modest PGC-1α overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar …
- PGC-1α regulation of mitochondrial degeneration in experimental diabetic neuropathy
- PGC-1α-mediated regulation of gene expression and metabolism: implications for nutrition and exercise prescriptions
- TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice
- Effects of high‐intensity intermittent swimming on PGC‐1α protein expression in rat skeletal muscle
- Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the PGC-1α Gene and Age-Dependent Metabolic Dysfunction in the Offspring
- PGC-1α and myokines in the aging muscle–a mini-review
- PGC-1α at the intersection of bioenergetics regulation and neuron function: from Huntington’s disease to Parkinson’s disease and beyond
- Rescue of dystrophic skeletal muscle by PGC-1α involves a fast to slow fiber type shift in the mdx mouse
- Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α expression in experimental stroke
- Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the …
- PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity
- Alterations in the mitochondrial regulatory pathways constituted by the nuclear co-factors PGC-1α or PGC-1β and mitofusin 2 in skeletal muscle in type 2 …
- Dissociation of increases in PGC-1α and its regulators from exercise intensity and muscle activation following acute exercise
- PGC-1α is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis
- The p38–PGC-1α–irisin–betatrophin axis: Exploring new pathways in insulin resistance
- PGC-1α: a master gene that is hard to master
- Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor γ coactivator-1 α (PGC-1α)
- The transcriptional coactivator PGC-1α is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis
- Peroxisomal proliferator-activated receptor-γ coactivator-1α (PGC-1α) enhances the thyroid hormone induction of carnitine palmitoyltransferase I (CPT-Iα)
- PGC-1α plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle
- Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle
- The microRNA miR-696 regulates PGC-1α in mouse skeletal muscle in response to physical activity
- The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1
- Effect of exercise intensity and AICAR on isoform-specific expressions of murine skeletal muscle PGC-1α mRNA: a role of β2-adrenergic receptor activation
- Whole body overexpression of PGC-1α has opposite effects on hepatic and muscle insulin sensitivity
- Mitochondrial defect and PGC-1α dysfunction in parkin-associated familial Parkinson’s disease
- Transcriptional coactivator PGC-1α promotes peroxisomal remodeling and biogenesis
- The p65 subunit of NF-κB binds to PGC-1α, linking inflammation and metabolic disturbances in cardiac cells
- Localization of the transcriptional coactivator PGC‐1α to GABAergic neurons during maturation of the rat brain
- Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1α …
- p53 orchestrates the PGC-1α-mediated antioxidant response upon mild redox and metabolic imbalance
- Neuronal inactivation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) protects mice from diet-induced obesity and leads to …
- HIF-1α and HIF-2α are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-1α-mediated fatty acid β-oxidation
- Role of PGC-1α in exercise and fasting-induced adaptations in mouse liver
- Exercise and PGC-1α-independent synchronization of type I muscle metabolism and vasculature by ERRγ
- An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle
- Twist-1 is a PPARδ-inducible, negative-feedback regulator of PGC-1α in brown fat metabolism
- TNF‐α‐mediated reduction in PGC‐1α may impair skeletal muscle function after cigarette smoke exposure
- The homeobox protein Prox1 is a negative modulator of ERRα/PGC-1α bioenergetic functions
- Complex haplotypes of the PGC-1α gene are associated with carbohydrate metabolism and type 2 diabetes
- Role of PGC-1α in muscle function and aging
- The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1α
- Decorin induces mitophagy in breast carcinoma cells via peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitostatin
- Expression of the thermogenic nuclear hormone receptor coactivator PGC-1α is reduced in the adipose tissue of morbidly obese subjects
- Exercise, PGC-1α, and metabolic adaptation in skeletal muscle
- RETRACTED: Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype
- Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1α
- Endurance training increases skeletal muscle LKB1 and PGC-1α protein abundance: effects of time and intensity
- Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1α) expression in the murine brain
- Human skeletal muscle fibre type variations correlate with PPARα, PPARδ and PGC‐1α mRNA
- Alternative splice variant PGC-1α-b is strongly induced by exercise in human skeletal muscle
- PCAF improves glucose homeostasis by suppressing the gluconeogenic activity of PGC-1α
- Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients
- Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS
- SIRT5 is under the control of PGC‐1α and AMPK and is involved in regulation of mitochondrial energy metabolism
- Exercise with low glycogen increases PGC-1α gene expression in human skeletal muscle
- PGC-1α increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4
- Selenoprotein P expression is controlled through interaction of the coactivator PGC‐1α with FoxO1a and hepatocyte nuclear factor 4α transcription factors
- PGC-1α overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion
- Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation
- PGC‐1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model
- PGC-1α‘s relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1α and PGC-1β protein
- Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program
- Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α
- Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1α/LRP130 complex
- Metformin increases the PGC-1α protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo
- Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex
- Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic …
- T3-mediated expression of PGC-1α via a far upstream located thyroid hormone response element
- AMPK inhibits myoblast differentiation through a PGC-1α-dependent mechanism
- PGC-1α is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle
- PGC-1α Promotes the Growth of ErbB2/Neu–Induced Mammary Tumors by Regulating Nutrient SupplyImpact of PGC-1α on Cancer Metabolism
- PGC-1α determines light damage susceptibility of the murine retina
- The relationship between muscle fiber type-specific PGC-1α content and mitochondrial content varies between rodent models and humans
- Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction
- Effects of PGC-1α on TNF-α–induced MCP-1 and VCAM-1 expression and NF-κB activation in human aortic smooth muscle and endothelial cells
- The PGC-1α-dependent pathway of mitochondrial biogenesis is upregulated in type I endometrial cancer
- Effect of exercise intensity on isoform-specific expressions of NT-PGC-1α mRNA in mouse skeletal muscle
- PPARδ agonism activates fatty acid oxidation via PGC-1α but does not increase mitochondrial gene expression and function
- PGC-1α induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle
- WldS and PGC-1α regulate mitochondrial transport and oxidation state after axonal injury
- Loss of PGC-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation
- Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A
- … induced increase in gene expression of peroxisome proliferator-activated receptor (PPAR)-γ coactivator 1α (PGC-1α), mitochondrial uncoupling protein 3 …
- PGC-1α mediates differentiation of mesenchymal stem cells to brown adipose cells
- Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1α: functional implications in hepatic …
- Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-α/PGC-1α gene regulatory pathway
- PGC-1α is required for training-induced prevention of age-associated decline in mitochondrial enzymes in mouse skeletal muscle
- Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1α/mitofusin-2 regulatory pathway in response to physical activity
- Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
- Structural and biochemical basis for the binding selectivity of peroxisome proliferator-activated receptor γ to PGC-1α
- PGC-1α/β induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders
- Endoplasmic reticulum stress links hepatitis C virus RNA replication to wild-type PGC-1α/liver-specific PGC-1α upregulation
- PGC-1α induction in pulmonary arterial hypertension
- Selective activation of AMPK‐PGC‐1α or PKB‐TSC2‐mTOR signaling can explain specific adaptive responses to endurance or resistance training‐like electrical …
- Fetal PGC-1α overexpression programs adult pancreatic β-cell dysfunction
- PGC-1α and exercise: important partners in combating insulin resistance
- Regulation of NT-PGC-1α subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1
- Characterization of novel peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) isoform in human liver
- The corepressor NCoR1 antagonizes PGC-1α and estrogen-related receptor α in the regulation of skeletal muscle function and oxidative metabolism
- Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury
- PGC-1α and reactive oxygen species regulate human embryonic stem cell-derived cardiomyocyte function
- Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart
- Localization of sequence variations in PGC-1α influence their modifying effect in Huntington disease
- Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophin
- The Drosophila PGC-1α Homolog spargel Modulates the Physiological Effects of Endurance Exercise
- Common polymorphisms of the PPAR-γ2 (Pro12Ala) and PGC-1α (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance …
- Tumor necrosis factor and interleukin 1 decrease RXRα, PPARα, PPARγ, LXRα, and the coactivators SRC-1, PGC-1α, and PGC-1β in liver cells
- Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1α) improve lipid utilisation, insulin signalling and glucose …
- Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1α and PPARβ/δ gene expression upon rosiglitazone treatment in obese patients with type …
- Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type
- Ubiquitin proteasome-dependent degradation of the transcriptional coactivator PGC-1α via the N-terminal pathway
- NT-PGC-1α protein is sufficient to link β3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis
- Identification of novel targets for PGC-1α and histone deacetylase inhibitors in neuroblastoma cells
- Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function
- Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity
- Parkin’control: regulation of PGC-1α through PARIS in Parkinson’s disease
- Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington’s disease
- Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle
- Cloning and expression of PPARγ and PGC-1α from the hibernating ground squirrel, Spermophilus tridecemlineatus
- Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC‐1α pathway
- … of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by truncated peroxisome proliferator-activated receptor γ coactivator (PGC)-1α
- Impaired coactivator activity of the Gly482 variant of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) on mitochondrial transcription factor A (Tfam) …
- Inactivation of Foxo3a and subsequent downregulation of PGC-1α mediate nitric oxide-induced endothelial cell migration
- Treadmill training increases SIRT-1 and PGC-1α protein levels and AMPK phosphorylation in quadriceps of middle-aged rats in an intensity-dependent …
- CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis
- Protection against dexamethasone-induced muscle atrophy is related to modulation by testosterone of FOXO1 and PGC-1α
- PGC-1α is a key regulator of glucose-induced proliferation and migration in vascular smooth muscle cells
- Gene expression of PPARγ and PGC-1α in human omental and subcutaneous adipose tissues is related to insulin resistance markers and mediates beneficial …
- Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice
- Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2
- PGC-1α promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in mice
- IL-15 overexpression promotes endurance, oxidative energy metabolism, and muscle PPARδ, SIRT1, PGC-1α, and PGC-1β expression in male mice
- The astaxanthin-induced improvement in lipid metabolism during exercise is mediated by a PGC-1α increase in skeletal muscle
- PGC-1α: important for exercise performance?
- Baicalin increases VEGF expression and angiogenesis by activating the ERRα/PGC-1α pathway
- MicroRNA-149 inhibits PARP-2 and promotes mitochondrial biogenesis via SIRT-1/PGC-1α network in skeletal muscle
- Overexpression of PGC-1α increases fatty acid oxidative capacity of human skeletal muscle cells
- Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal …
- Calcineurin signaling and PGC-1α expression are suppressed during muscle atrophy due to diabetes
- Role of PGC-1α in exercise training-and resveratrol-induced prevention of age-associated inflammation
- Energizer: PGC-1α keeps the heart going
- Multiple signaling pathways regulate contractile activity‐mediated PGC‐1α gene expression and activity in skeletal muscle cells
- Muscle immobilization and remobilization downregulates PGC-1α signaling and the mitochondrial biogenesis pathway
- Peroxisome proliferator activated receptor α (PPARα) and PPAR gamma coactivator (PGC-1α) induce carnitine palmitoyltransferase IA (CPT-1A) via independent …
- Dynamic interactions and cooperative functions of PGC-1α and MED1 in TRα-mediated activation of the brown-fat-specific UCP-1 gene
- Analysis of PGC-1α variants Gly482Ser and Thr612Met concerning their PPARγ2-coactivation function
- Muscle type‐specific response of PGC‐1α and oxidative enzymes during voluntary wheel running in mouse skeletal muscle
- Developmental alterations in motor coordination and medium spiny neuron markers in mice lacking PGC-1α
- PGC-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf
- Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1α, drives utrophin gene expression at the neuromuscular junction
- PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons
- Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo
- PGC-1α is associated with C2C12 myoblast differentiation
- Free fatty acids increase PGC-1α expression in isolated rat islets
- Extranuclear localization of SIRT1 and PGC-1α: an insight into possible roles in diseases associated with mitochondrial dysfunction
- Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1α pathway
- Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC‐1α by PRMT1 and SIRT1
- Resveratrol exerts pharmacological preconditioning by activating PGC-1α
- The metabolic regulator PGC-1α directly controls the expression of the hypothalamic neuropeptide oxytocin
- Acute exercise modulates the Foxo1/PGC‐1α pathway in the liver of diet‐induced obesity rats
- Regulation of Ca2+ signalling and Ca2+-mediated cell death by the transcriptional coactivator PGC-1α
- Effects of post-exercise recovery in a cold environment on muscle glycogen, PGC-1α, and downstream transcription factors
- Inhibition of cardiac PGC‐1α expression abolishes ERβ agonist‐mediated cardioprotection following trauma‐hemorrhage
- PPARγ/PGC-1α pathway in E-cadherin expression and motility of HepG2 cells
- Metformin induces microRNA-34a to downregulate the Sirt1/PGC-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress …
- Impact of PGC-1α on the topology and rate of superoxide production by the mitochondrial electron transport chain
- PGC-1α serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy
- Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver
- Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex
- Skeletal muscle fibres synthesis in heart failure: role of PGC-1α, calcineurin and GH
- Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
- Cold-induced PGC-1α expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway
- Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway
- Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α
- Defining the action spectrum of potential PGC-1α activators on a mitochondrial and cellular level in vivo
- p53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left …
- The nuclear bile acid receptor FXR is activated by PGC-1α in a ligand-dependent manner
- The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading …
- PGC-1α signaling coordinates susceptibility to metabolic and oxidative injury in the inner retina
- IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1α
- Aluminium induced oxidative stress results in decreased mitochondrial biogenesis via modulation of PGC-1α expression
- PGC-1α Thr394Thr and Gly482Ser variants are significantly associated with T2DM in two North Indian populations: a replicate case-control study
- Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway
- Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC-1): requirement for hepatocyte nuclear factor 4α in gluconeogenesis
- PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer’s disease
- Skeletal muscle PGC-1α is required for maintaining an acute LPS-induced TNFα response
- Caloric restriction ameliorates kidney ischaemia/reperfusion injury through PGC‐1α–eNOS pathway and enhanced autophagy
- Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia
- The transcriptional coactivators, PGC-1α and β, cooperate to maintain cardiac mitochondrial function during the early stages of insulin resistance
- Tumour necrosis factor‐α promotes liver ischaemia‐reperfusion injury through the PGC‐1α/Mfn2 pathway
- The Gly482Ser missense mutation of the peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) gene associates with reduced insulin sensitivity …
- Potential roles of PINK1 for increased PGC-1α-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes
- Dysfunction of the PGC-1α-mitochondria axis confers adriamycin-induced podocyte injury
- Upregulation of PGC‐1α expression by A lzheimer’s disease‐associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP
- Studies of the Gly482Ser polymorphism of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) gene in Danish subjects with the metabolic …
- PGC-1α transcriptional response and mitochondrial adaptation to acute exercise is maintained in skeletal muscle of sedentary elderly males
- Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor γ coactivator (PGC-1α)
- FoxO6 and PGC-1α form a regulatory loop in myogenic cells
- Na, K-ATPase activity in mouse muscle is regulated by AMPK and PGC-1α
- Mechanism of cardiomyocyte PGC-1α gene regulation by ERRα
- Identification of ERRα as a specific partner of PGC‐1α for the activation of PDK4 gene expression in muscle
- Reduced hepatic mitochondrial respiration following acute high-fat diet is prevented by PGC-1α overexpression
- Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling
- The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway
- Calcium signalling in the regulation of PGC-1α, PDK4 and HKII mRNA expression
- High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPARα–FoxO3a–PGC-1α …
- Maternal protein restriction in rats leads to reduced PGC-1α expression via altered DNA methylation in skeletal muscle
- The metabolic regulator PGC-1α links hepatitis C virus infection to hepatic insulin resistance
- Molecular mechanisms underlying the development of endothermy in birds (Gallus gallus): a new role of PGC-1α?
- Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis
- The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling
- Combinatorial transcription factor regulation of the cyclic AMP-response element on the PGC-1α promoter in white 3T3-L1 and brown HIB-1B preadipocytes
- PGC-1α and PGC-1β increase CrT expression and creatine uptake in myotubes via ERRα
- The transcriptional co-activator PGC-1α up regulates apelin in human and mouse adipocytes
- Transient upregulation of PGC-1α diminishes cardiac ischemia tolerance via upregulation of ANT1
- Clking on PGC-1α to inhibit gluconeogenesis
- The effect of continuous and interval exercise on PGC‐1α and PDK4 mRNA in type I and type II fibres of human skeletal muscle
- PGC-1α inhibits oleic acid induced proliferation and migration of rat vascular smooth muscle cells
- Regulation of mitochondrial proliferation by PGC-1α induces cellular apoptosis in musculoskeletal malignancies
- Ethanol Suppresses PGC-1α Expression by Interfering with the cAMP-CREB Pathway in Neuronal Cells
- PGC‐1α gene expression is down‐regulated by Akt‐mediated phosphorylation and nuclear exclusion of FoxO1 in insulin‐stimulated skeletal muscle
- Burn plus lipopolysaccharide augments endoplasmic reticulum stress and NLRP3 inflammasome activation and reduces PGC-1α in liver
- SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1α
- PGC-1α/β upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations
- PGC-1α Gly482Ser polymorphism associates with hypertension among Danish whites
- Suppression of PGC-1α by ethanol: implications of its role in alcohol induced liver injury
- Fiber type conversion by PGC-1α activates lysosomal and autophagosomal biogenesis in both unaffected and Pompe skeletal muscle
- Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: role of PGC-1α
- PGC-1α induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells
- Lipoic acid restores age‐associated impairment of brain energy metabolism through the modulation of A kt/JNK signaling and PGC 1α transcriptional pathway
- Effects of the Peroxisome Proliferator Activated Receptor‐γ Coactivator‐1α (PGC‐1α) Thr394Thr and Gly482Ser Polymorphisms on Rosiglitazone Response in …
- Transcriptional control of the PGC-1α gene in skeletal muscle in vivo
- Lithium increases PGC‐1α expression and mitochondrial biogenesis in primary bovine aortic endothelial cells
- RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and modulates brown fat cell metabolism
- The asymmetric binding of PGC-1α to the ERRα and ERRγ nuclear receptor homodimers involves a similar recognition mechanism
- Rescue of dystrophic skeletal muscle by PGC-1α involves restored expression of dystrophin-associated protein complex components and satellite cell signaling
- Cardioprotection against doxorubicin by metallothionein Is associated with preservation of mitochondrial biogenesis involving PGC-1α pathway
- Maintaining PGC‐1α expression following pressure overload‐induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function
- Fasting-induced hepatic production of DHEA is regulated by PGC-1α, ERRα, and HNF4α
- Positive correlation between PPARγ/PGC-1α and γ-GCS in lungs of rats and patients with chronic obstructive pulmonary disease
- Transcriptional activity of PGC-1α and NT-PGC-1α is differentially regulated by twist-1 in Brown fat metabolism
- The control of UCP1 is dissociated from that of PGC-1α or of mitochondriogenesis as revealed by a study using β-less mouse brown adipocytes in culture
- Oxidative status of muscle is determined by p107 regulation of PGC-1α
- Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1α
- The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes
- Icariin promotes expression of PGC‐1α, PPARα, and NRF‐1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro1
- PGC‐1α encoded by the PPARGC1A gene regulates oxidative energy metabolism in equine skeletal muscle during exercise
- Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling
- Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) stimulates VLDL assembly through activation of cell death-inducing DFFA-like effector B …
- Roles of transcriptional corepressor RIP140 and coactivator PGC-1α in energy state of chronically infarcted rat hearts and mitochondrial function of cardiomyocytes
- Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron–sulfur cluster depletion in human skeletal muscle
- PGC-1α regulates translocated in liposarcoma activity: role in oxidative stress gene expression
- Acetylcholine promotes ROS detoxification against hypoxia/reoxygenation-induced oxidative stress through FoxO3a/PGC-1α dependent superoxide dismutase
- ApoE−/− PGC-1α−/− mice display reduced IL-18 levels and do not develop enhanced atherosclerosis
- Peroxisome proliferator activated receptor-alpha (PPARα) and PPAR gamma coactivator-1alpha (PGC-1α) regulation of cardiac metabolism in diabetes
- MicroRNA-23a mediates mitochondrial compromise in estrogen deficiency-induced concentric remodeling via targeting PGC-1α
- Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1α and AMPK activation
- Transcriptional network analysis in muscle reveals AP-1 as a partner of PGC-1α in the regulation of the hypoxic gene program
- Mice lacking the transcriptional coactivator PGC-1α exhibit alterations in inhibitory synaptic transmission in the motor cortex
- A single nucleotide polymorphism in the coding region of PGC-1α is a male-specific modifier of Huntington disease age-at-onset in a large European cohort
- Making muscle or mitochondria by selective splicing of PGC-1α
- Communication between the ERRα homodimer interface and the PGC-1α binding surface via the helix 8–9 loop
- Co-ingestion of carbohydrate and whey protein isolates enhance PGC-1α mRNA expression: a randomised, single blind, cross over study
- Multiple binding modes between HNF4α and the LXXLL motifs of PGC-1α lead to full activation
- ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1α levels in Aβ-injected rats
- NT-PGC-1α activation attenuates high-fat diet–induced obesity by enhancing brown fat thermogenesis and adipose tissue oxidative metabolism
- NMDA receptor dependent PGC-1α up-regulation protects the cortical neuron against oxygen-glucose deprivation/reperfusion injury
- Short term exercise induces PGC-1α, ameliorates inflammation and increases mitochondrial membrane proteins but fails to increase respiratory enzymes in …
- Gene program-specific regulation of PGC-1α activity
- PGC-1α increases PDH content but does not change acute PDH regulation in mouse skeletal muscle
- Energy dysfunction in Huntington’s disease: insights from PGC-1α, AMPK, and CKB
- Inverse relationship between PGC-1α protein expression and triacylglycerol accumulation in rodent skeletal muscle
- Acetyl-l-Carnitine Activates the Peroxisome Proliferator-Activated Receptor-γ Coactivators PGC-1α/PGC-1β–Dependent Signaling Cascade of Mitochondrial …
- PGC-1α Gly482Ser polymorphism is associated with the plasma adiponectin level in type 2 diabetic men
- The effect of overexpression of PGC-1α on the mtDNA4834 common deletion in a rat cochlear marginal cell senescence model
- Promoting PGC-1α-driven mitochondrial biogenesis is detrimental in pressure-overloaded mouse hearts
- Association of the PGC-1α rs8192678 variant with microalbuminuria in subjects with type 2 diabetes mellitus
- Peroxisomal proliferator activated receptor gamma coactivator (PGC-1α) stimulates carnitine palmitoyltransferase I (CPT-Iα) through the first intron
- The nuclear receptor coactivator PGC-1α exhibits modes of interaction with the estrogen receptor distinct from those of SRC-1
- Activating mitochondrial regulator PGC-1α expression by astrocytic NGF is a therapeutic strategy for Huntington’s disease
- PGC-1α is induced by parathyroid hormone and coactivates Nurr1-mediated promoter activity in osteoblasts
- Roles of histone deacetylation and AMP kinase in regulation of cardiomyocyte PGC-1α gene expression in hypoxia
- cAMP-mediated regulation of HNF-4α depends on the level of coactivator PGC-1α
- Lithium chloride inhibits vascular smooth muscle cell proliferation and migration and alleviates injury-induced neointimal hyperplasia via induction of PGC-1α
- PGC-1α attenuates neointimal formation via inhibition of vascular smooth muscle cell migration in the injured rat carotid artery
- The effects of running exercise on oxidative capacity and PGC-1α mRNA levels in the soleus muscle of rats with metabolic syndrome
- Fine-tuned regulation of the PGC-1α gene transcription by different intracellular signaling pathways
- … due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) …
- Glucocorticoid receptor mediated repression of human insulin gene expression is regulated by PGC-1α
- A PGC-1α-and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance
- Dynamic mobilization of PGC-1α mediates mitochondrial biogenesis for the protection of RGC-5 cells by resveratrol during serum deprivation
- Striated muscle activator of Rho signalling (STARS) is a PGC‐1α/oestrogen‐related receptor‐α target gene and is upregulated in human skeletal muscle after …
- Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset
- Differential expression of PGC-1α and metabolic sensors suggest age-dependent induction of mitochondrial biogenesis in Friedreich ataxia fibroblasts
- Enhanced lipid—but not carbohydrate—supported mitochondrial respiration in skeletal muscle of PGC‐1α overexpressing mice
- Impaired exercise-induced mitochondrial biogenesis in the obese Zucker rat, despite PGC-1α induction, is due to compromised mitochondrial translation elongation
- T3-mediated gene expression is independent of PGC-1α
- Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression …
- Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity
- Hyperhomocysteinemia attenuates angiogenesis through reduction of HIF-1α and PGC-1α levels in muscle fibers during hindlimb ischemia
- Aspirin may promote mitochondrial biogenesis via the production of hydrogen peroxide and the induction of Sirtuin1/PGC-1α genes
- Coactivator PGC-1α regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes
- β-Adrenergic stimulation does not activate p38 MAP kinase or induce PGC-1α in skeletal muscle
- Effects of PPARα/PGC-1α on the myocardial energy metabolism during heart failure in the doxorubicin induced dilated cardiomyopathy in mice
- Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation injury through AMPK/eNOS/PGC-1α signaling pathway
- PPARGC1A/PGC-1α, TFEB and enhanced proteostasis in Huntington disease: Defining regulatory linkages between energy production and protein–organelle quality …
- Thyroid hormone effects on LKB1, MO25, phospho-AMPK, phospho-CREB, and PGC-1α in rat muscle
- CMZ reversed chronic ethanol-induced disturbance of PPAR-α possibly by suppressing oxidative stress and PGC-1α acetylation, and activating the MAPK …
- PGC-1α mRNA level and oxidative capacity of the plantaris muscle in rats with metabolic syndrome, hypertension, and type 2 diabetes
- Calcineurin A and CaMKIV transactivate PGC-1α promoter, but differentially regulate cytochrome c promoter in rat skeletal muscle
- Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1α and dephosphorylation of FoxO1
- Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC‐1α pathway and Insig1/2 expression in hepatocytes
- Sequential signaling cascade of IL-6 and PGC-1α is involved in high glucose-induced podocyte loss and growth arrest
- PGC-1α mediated muscle aerobic adaptations to exercise, heat and cold exposure
- PGC-1α coactivates estrogen-related receptor-α to induce the expression of glucokinase
- RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis
- PGC-1α integrates glucose metabolism and angiogenesis in multiple myeloma cells by regulating VEGF and GLUT-4
- The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1α expression
- Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1α are required for time-specific gene expression during liver …
- Transcriptional regulation by nuclear corepressors and PGC-1α: implications for mitochondrial quality control and insulin sensitivity
- Evaluation of lovastatin effects on expression of anti-apoptotic Nrf2 and PGC-1α genes in neural stem cells treated with hydrogen peroxide
- Peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α) enhances engraftment and angiogenesis of mesenchymal stem cells in diabetic hindlimb …
- Neuropathology of partial PGC-1α deficiency recapitulates features of mitochondrial encephalopathies but not of neurodegenerative diseases
- Transcriptional co-activator PGC-1α gene is associated with chicken skeletal muscle fiber types
- Sphingosine 1-phosphate (S1P) promotes mitochondrial biogenesis in Hep G2 cells by activating peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α)
- Regulation of PGC-1α and PGC-1α-responsive genes with forskolin-induced Schwann cell differentiation
- Induction of PGC-1α expression can be detected in blood samples of patients with ST-segment elevation acute myocardial infarction
- PGC-1α gene and physical activity in type 2 diabetes mellitus
- DNA damage induces down-regulation of PEPCK and G6P gene expression through degradation of PGC-1α
- … factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1α
- Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1α
- Epinephrine and AICAR-induced PGC-1α mRNA expression is intact in skeletal muscle from rats fed a high-fat diet
- Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1α in adulthood
- Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals
- Differential regulation of PGC-1α expression in rat liver and skeletal muscle in response to voluntary running
- 17β-Estradiol inhibits oleic acid-induced rat VSMC Proliferation and migration by restoring PGC-1α expression
- Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses
- The mitochondrial SIRT1–PGC-1α axis in podocyte injury
- The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells
- Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1α and MED1 complex
- Regulation of transcriptional coactivator PGC-1α
- PGC‐1α‐Induced Mitochondrial Alterations in 3T3 Fibroblast Cells
- Effects of electroacupuncture on PGC-1α expression in brown adipose tissue
- Modulation of PGC-1α activity as a treatment for metabolic and muscle-related diseases
- Effect of Opuntia humifusa Supplementation and Acute Exercise on Insulin Sensitivity and Associations with PPAR-γ and PGC-1α Protein Expression in Skeletal …
- PGC-1α: looking behind the sweet treat for porphyria
- Fasting induces the expression of PGC-1α and ERR isoforms in the outer stripe of the outer medulla (OSOM) of the mouse kidney
- Myocardial ischaemic and diazoxide preconditioning both increase PGC-1α and reduce mitochondrial damage
- Up-regulation of the Sirtuin 1 (Sirt1) and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) genes in white adipose tissue of Id1 protein …
- PGC-1α expression is increased in leukocytes in experimental acute pancreatitis
- Control of endothelial function and angiogenesis by PGC-1α relies on ROS control of vascular stability
- Oxidants and Ca+ 2 induce PGC-1α degradation through calpain
- Quantitative immuno-electron microscopic analysis of depolarization-induced expression of PGC-1α in cultured rat visual cortical neurons
- Circadian metabolic regulation through crosstalk between casein kinase 1δ and transcriptional coactivator PGC-1α
- Expression of Adenine Nucleotide Translocase (ANT) Isoform Genes Is Controlled by PGC‐1α Through Different Transcription Factors
- Cilostazol promotes mitochondrial biogenesis in human umbilical vein endothelial cells through activating the expression of PGC-1α
- Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy
- A novel PGC-1α isoform in brain localizes to mitochondria and associates with PINK1 and VDAC
- Targeting EP4 by curcumin through cross talks of AMP-dependent kinase alpha and p38 mitogen-activated protein kinase signaling: the role of PGC-1α and Sp1
- Enhanced short-term improvement of insulin response to a low-caloric diet in obese carriers the Gly482Ser variant of the PGC-1α gene
- Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α mouse cortex: a potential lipidomic role of PGC-1α in neurodegeneration
- The key role of PGC-1α in mitochondrial biogenesis and the proliferation of pulmonary artery vascular smooth muscle cells at an early stage of hypoxic exposure
- … roles of myostatin and PGC-1α in the increase of skeletal muscle and transformation of fiber type in cold-exposed chicks: Expression of myostatin and PGC-1α in …
- Combined whole-body vibration, resistance exercise, and sustained vascular occlusion increases PGC-1α and VEGF mRNA abundances
- Time-dependent effects of systemic lipopolysaccharide injection on regulators of antioxidant defence Nrf2 and PGC-1α in the neonatal rat brain
- Increased renal methylglyoxal formation with down-regulation of PGC-1α-FBPase pathway in cystathionine γ-lyase knockout mice
- Altering the redox state of skeletal muscle by glutathione depletion increases the exercise‐activation of PGC‐1α
- Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver
- PGC-1α accelerates cytosolic Ca2+ clearance without disturbing Ca2+ homeostasis in cardiac myocytes
- PGC-1α prevents apoptosis in adipose-derived stem cells by reducing reactive oxygen species production in a diabetic microenvironment
- Sterol-independent repression of low density lipoprotein receptor promoter by peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α)
- Enhanced differentiation of three-gene-reprogrammed induced pluripotent stem cells into adipocytes via adenoviral-mediated PGC-1α overexpression
- Lack of Genetic Associations of PPAR-γ and PGC-1α with Alzheimer’s Disease and Parkinson’s Disease with Dementia
- A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1α expression and mitochondrial biogenesis
- Regulatory role of PGC-1α/PPAR signaling in skeletal muscle metabolic recruitment during cold acclimation
- The effects of PGC-1α on control of microvascular Po2 kinetics following onset of muscle contractions
- Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) upregulated E-cadherin expression in HepG2 cells
- PGC-1α regulates hepatic hepcidin expression and iron homeostasis in response to inflammation
- PPARγ activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1α and D2
- Distinct ligand-dependent and independent modes of thyroid hormone receptor (TR)/PGC-1α interaction
- Ndrg2 is a PGC-1α/ERRα target gene that controls protein synthesis and expression of contractile-type genes in C2C12 myotubes
- New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases
- The metabolic regulator PGC‐1α links anti‐cancer cytotoxic chemotherapy to reactivation of hepatitis B virus
- The coactivator PGC-1α regulates skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet
- New gene targets of PGC-1α and ERRα co-regulation in C2C12 myotubes
- Inverse Regulation of the Cytosolic Ca2+ Buffer Parvalbumin and Mitochondrial Volume in Muscle Cells via SIRT1/PGC-1α Axis
- Adenosine prevents TNFα-induced decrease in endothelial mitochondrial mass via activation of eNOS-PGC-1α regulatory axis
- Localization and regulation of the N terminal splice variant of PGC-1α in adult skeletal muscle fibers
- Atorvastatin Attenuates TNF-α–induced Increase of Glucose Oxidation Through PGC-1α Upregulation in Cardiomyocytes
- The peroxisome proliferator-activated receptor gamma coactivator-1 alpha gene (PGC-1α) is not associated with type 2 diabetes mellitus or body mass index among …
- Muscling in on PGC-1α for improved quality of life in ALS
- Epigenetic modulation of PGC-1α activity by GCN5 inhibitors: WO2010007085: Novartis Institutes for BioMedical Research, Inc.
- High circulating levels of RBP4 and mRNA levels of aP2, PGC‐1α and UCP‐2 predict improvement in insulin sensitivity following pioglitazone treatment of drug‐naïve …
- Dissociation between PGC-1α and GLUT-4 expression in skeletal muscle of rats fed a high-fat diet
- Effectiveness of sub-maximal intermittent exercise on muscle glycogen depletion, PGC-1α and PDK-4 gene expression
- Targeting PGC-1α to overcome the harmful effects of glucocorticoids in porcine neonatal pancreas cell clusters
- PGC-1α induces dynamic protein interactions on the ERRα gene multi-hormone response element nucleosome in kidney cells
- Change in PGC-1α expression in rat skeletal muscle after low-intensity prolonged swimming exercise
- Mitochondrial and sarcoplasmic protein changes in hearts from copper-deficient rats: up-regulation of PGC-1α transcript and protein as a cause for mitochondrial …
- The effect of SIRT1 protein knock down on PGC-1α acetylation during skeletal muscle contraction
- Impact of angiotensin II on skeletal muscle metabolism and function in mice: contribution of IGF-1, Sirtuin-1 and PGC-1α
- Nifedipine increases energy expenditure by increasing PGC-1α expression in skeletal muscle
- Expression pattern of PGC-1α and Mfn2 in insulin resistance and recovery in rat
- Impaired ubiquitin‐proteasome‐mediated PGC‐1α protein turnover and induced mitochondrial biogenesis secondary to complex‐I deficiency
- Photobiomodulation on bax and Bcl-2 proteins and SIRT1/PGC-1α axis mRNA expression levels of aging rat skeletal muscle
- Downregulation of Pgc‐1α expression by tea leaves and their by‐products
- Alpha-lipoic acid increases energy expenditure by enhancing AMPK-PGC-1α signalling in the skeletal muscle of aged mice
- Neuronal activity controls the antagonistic balance between PGC-1α and SMRT in regulating antioxidant defences
- Improvement of myocardial lipid accumulation and prevention of PGC-1α induction by fenofibrate
- Association of PGC-1α gene with intramuscular fat content and muscle fiber traits and gene expression in Tibetan pigs.
- Gene expression of calpain 3 and PGC-1α is correlated with meat tenderness in the longissimus dorsi muscle of Sutai pigs
- PGC-1α: The Missing Ingredient for Mesenchymal Stem Cell–Mediated Angiogenesis
- The role of PGC-1α in regulation of skeletal muscle metabolism
- Identification of a novel human glucagon receptor promoter: Regulation by cAMP and PGC-1α
- The region of CQQQKPQRRP of PGC-1α interacts with the DNA-binding complex of FXR/RXRα
- PGC-1α controls the transcription of the SIRT3 gene, an essential component of the thermogenic brown adipocyte phenotype
- Down‐expression of PGC‐1α partially mediated by JNK/c‐Jun through binding to CRE site during apoptotic procedure in cerebellar granule neurons
- PPARβ/δ Activation prevents hypertriglyceridemia caused by a high fat diet. Involvement of AMPK and PGC-1α-Lipin1-PPARα pathway
- Full-length PGC-1α salvages the phenotype of a mouse model of human neuropathy through mitochondrial proliferation
- PGC‐1α plays a protective role against oxidative stress in skeletal muscle
- Effect of PGC-1α on proliferation, migration, and transdifferentiation of rat vascular smooth muscle cells induced by high glucose
- PGC-1α and metabolic control in skeletal and cardiac muscle
- Interleukin enhancer-binding factor 3 functions as a liver receptor homologue-1 co-activator in synergy with the nuclear receptor co-activators PRMT1 and PGC-1α
- Construction and characterization of peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1α over-expressing cell line derived from …
- Cloning, expression and polymorphism analyses of PGC-1α gene of Schizothorax prenanti.
- Suppression of retinal neovascularization by small interfering RNA targeting PGC-1α
- TNF and IL-1 decrease RXRα, PPARα, PPARγ, LXRα, and the coactivators SRC-1, PGC-1α, and PGC-1β in liver cells
- The role of PGC-1α in the regulation of skeletal muscle metabolism
- AMPK-SIRT1-PGC-1α signaling regulates mitochondrial function in human articular chondrocytes
- PGC‐1α protects dopaminergic neurons in the MPTP mouse model of Parkinson’s disease
- Effects of Exercise Intensity on PGC-1α, PPAR-γ, and Insulin Resistance in Skeletal Muscle of High Fat Diet-fed Sprague-Dawley Rats
- Association of PGC-1α gene polymorphism with type 2 diabetes mellitus
- PGC-1α gene expression and the influence of dietary n-3 HUFAs in grass carp (Ctenopharyngodon idellus).
- Erratum to “Curcumin inhibits hepatitis B virus via down‐regulation of the metabolic coactivator PGC‐1α”[FEBS Lett. 584 (2010) 2485–2490]
- Exercise‐induced PGC‐1α mRNA increase is independent on calcineurin activation in skeletal muscle of rats
- Similar increases of PGC-1α gene expression in the soleus muscle of healthy male rats following high intensity interval and aerobic training
- Analyzing phosphorylation-dependent regulation of subcellular localization and transcriptional activity of transcriptional coactivator NT-PGC-1α
- Truncated PGC—1α and angiogenesis in skeletal muscle
- Comment on Laker et al. Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the PGC-1α Gene and Age-Dependent Metabolic Dysfunction in the …
- Role of PGC-1α and PGC-1β in inflammatory processes
- PGC-1α Gly482Ser polymorphism increases the susceptibility to NAFLD in type 2 diabetic patients
- Response to Comment on Laker et al. Exercise Prevents Maternal High-Fat Diet–Induced Hypermethylation of the PGC-1α Gene and Age-Dependent Metabolic …
- Regulation of hepatic metabolism through PGC-1α-mediated pathways
- Effect of aerobic exercise on leptin and PGC-1α gene expression in a unique cohort of morbidly obese Polynesians with type 2 diabetes
- Association of PGC-1α Gene Polymorphism with Type 2 Diabetes Mellitus.
- Effect of Resistance Exercise Intensity on the mRNA Expression of PGC-1α Isoforms in Human Skeletal Muscle
- Correction: Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice
- AMP‐activated protein kinase‐regulated activation of the PGC‐1α promoter in skeletal muscle cells
- PGC‐1α regulates both the constitutive and drug‐inducible expression of human CYP2C9
- Differentiation of PGC-1α gene expression in skeletal muscles of two chicken breeds.
- Role of coactivator PGC-1α in energy balance: Importance in the production of beef cattle
- Voluntary wheel running is necessary for hepatic PGC‐1α adenovirus overexpression to increase hepatic mitochondria in LCR rats (LB741)
- PGC-1α overexpression increases lipid oxidation in myocytes from extremely obese individuals
- PGC‐1α deletion accelerates angiotensin II induced endothelial dysfunction by increasing mitochondrial oxidative stress and vascular aging
- Effects of PGC-1α on endothelial function and apoptosis
- IDENTIFICATION OF HUMAN PGC-1α-b ISOFORMS USING A NOVEL PGC-1α-b SPECIFIC ANTIBODY
- The role of PGC-1α and PGC-1β in myotube protein synthesis
- One more trick in the regulation of PGC-1α
- Effect of high glucose peritoneal dialysis solution on PGC-1α expression and mitochondria related oxidative injury in human peritoneal mesothelial cells
- Negative regulation of PGC-1α by NF-κB
- T3-mediated gene expression is independent of PGC-1α
- P0221 The negative regulatory role of PGC-1α in pathogenesis of hepatocellular carcinoma
- INVERSE RELATIONSHIP BETWEEN PGC-1α PROTEIN EXPRESSION
- Roles of PGC-1α/PPARs pathway in regulating insulin sensitivity in mouse skeletal muscle cells under prolonged hypoxia
- Exercise Induced PGC-1α Transcriptional Factors in
- PGC-1α pathway as a potential target for cancer treatment.
- The role of the coactivators PGC-1α and PGC-1β in retina and skeletal muscle
- Evolutionary and functional variation of PGC‐1α in vertebrates
- The role of PGC-1α and PGC-1β during inflammatory processes in skeletal muscle
- The protective role of PGC‐1α in the recovery of muscle disuse atrophy
- Photoreceptor sensitivity to oxidative stress can by regulated by non-redundant roles of PGC-1α and PGC-1β
- Effect of kidney-tonifying, spleen-strengthening, and blood stasis removing recipe on the expression ERRα and PGC-1α mRNA in the bone marrow of the femurs in …
- Effects of acute bouts of running and swimming exercise on PGC-1α
- The PGC-II Polymorphism of the Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Gene in Korean Subjects with the Metabolic Syndrome
- Analysis of neuronal transcripts of PGC-1α transgenic mice
- Phosphodiesterase inhibition increases PGC‐1α in muscle cells (1102.32)
- Regulation of PGC‐1α expression in skeletal muscle: Comparison of the effects of calcineurin and PKA/cAMP signaling on PGC‐1α transcription
- PGC-1α over-expression is related to increased cell proliferation and tumorigenesis
- Transcriptional regulation of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promoter
- PGC‐1α‐mediated branched‐chain amino acid metabolism in the skeletal muscle (820.1)
- Fiber type specific PGC‐1α content and its relation to capillarization and mitochondrial content
- Understanding the function of PGC-1α Isoforms in ß-cell survival and diabetes
- PGC-1α and PGC-1β have both similar and distinct effects upon myofiber switching towards an oxidative phenotype.
- Upstream activators of PGC‐1α transcription with acute contractile activity (1164.4)
- Activation of the Nuclear Receptor Coactivator PGC-1α Mediates an Atheroprotective Effect
- Mitochondrial function and protein expression profile in skeletal muscle from PGC‐1α null mice
- PGC‐1α over‐expression rescues dystrophin‐deficient skeletal muscle
- Mst1 Inhibits PGC-1α via Inhibition of CREB
- Relationship of PGC-1α Gene Polymorphism With Insulin Resistance Syndrome in Korean Children
- Calcineurin-mediated Activation of the Human PPARγ Coactivator-1α (PGC-1α) Gene promoter is Influenced by Haplotype
- A Mechanistic look at the Regulatory Functions of Peroxisome Proliferator-Activated Receptor γ (PPARγ) Coactivator 1α (PGC-1α) and Estrogen Related Receptor …
- PPARβ/δ is not required by PGC‐1α to enhance skeletal muscle oxidative metabolism (1164.3)
- PROTEIN EXPRESSON OF MITOCHONDRIAL MRNA TRANSLATION FACTORS IS DRIVEN BY PGC-1α
- Eating competence is related to PPARβ/δ and PGC‐1α genotypes
- Neuroprotection from the huntingtin-repressed transcriptional coactivator PGC-1α
- Whole-Body Overexpression of PGC-1α Has Opposite Effects on Hepatic and Muscle Insulin Sensitivity.
- Glucocorticoid receptor mediated repression of human insulin gene expression is regulated by PGC-1α
- Postnatal PGC‐1α over‐expression improves muscle function in a mouse model of Duchenne muscular dystrophy
- Revisiting the observation of anxiety-like behavior and assessing phenotypic progression in PGC-1α-deficient mice
- PGC-1α modulates skeletal muscle regeneration by affecting immune response and satellite cell behavior
- Influence of contractile activity‐induced intracellular signaling on PGC‐1α activity in muscle cells
- PGC‐1α gene transfer rescues dystrophic muscle from advanced disease progression (884.18)
- Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training
- Acute high‐intensity exercise increases the nuclear abundance of PGC‐1α in equine skeletal muscle
- Intensity, muscle activation, and PGC‐1α expression are dissociated following supramaximal interval exercise
- The relationship between rs2970847 polymorphism of PGC-1α gene and susceptibility to type 2 diabetes: a systematic review and meta-analysis
- Regulation of skeletal muscle plasticity by the transcriptional coregulators PGC-1α and NCoR1
- Postnatal PGC‐1α gene transfer attenuates acute injury in mdx mice
- Thioredoxin1 Upregulates PGC-1α and NRF1 and Enhances Mitochondrial Functions
- Involvement of PGC-1α Signaling in Retinal Astrocyte Activation and Ganglion Cell Damage
- The Protective Role of AMPK/SIRT1/PGC-1α Signalling in Retinal Astrocytes
- A PGC‐1α: O‐GlcNAc Transferase Complex Regulates Foxo1a Activation in Response to Glucose
- ERRα rescues histone deacetylation‐mediated down‐regulation of PGC‐1α expression in hypoxia
- Uncoordinate regulation of PGC-1α and respiratory chain gene expression in the development of heart failure in rats
- Abstract LB-278: Metabolic regulator PGC-1α promotes angiogenesis and metastasis in nutrient deprivation selected tumor cells.
- PGC-1α: A Multifunctional Transcriptional Coactivator Involved in Human Metabolic Disorders
- C07 Localisation of sequence variations in PGC-1α influence their modifying effect in Huntington’s disease
- Peptide Therapeutics for the Prevention of Cancers and Cardiovascular Diseases: The Special Value of the PGC-1α Pathway
- A new SNP of PGC-1α gene associated with abdominal fat in chickens.
- The effects of PGC‐1α on control of microvascular PO2 kinetics following onset of muscle contractions
- Suppression of calcineurin signaling reduces PGC‐1α expression in a chronic model of muscle atrophy
- Conditional knock‐down of the transcriptional coactivator PGC‐1α in mice using Cre‐LoxP induced RNA interference
- PGC‐1α is required for exercise‐induced mitochondrial biogenesis, but not fiber type transformation, in skeletal muscle
- Possible control of mitochondrial populations by PGC-1α in the 13-lined ground squirrel retina
- PEROXYSOME PROLIFERATOR-ACTIVATED RECEPTORS AND THEIR COACTIVATOR—PGC-1α—IN PHYSIOLOGY AND PATHOLOGY OF MYOCARDIUM
- PGC− 1α Methylation: Molecular Links between Fat Metabolism, Mitochondrial Regulation and Parkinson’s Disease (P05. 060)
- Glucocorticoids attenuate calcineurin signaling and PGC‐1α expression in muscle during diabetes and kidney disease
- The molecular dissection of the regulation of PGC-1α and the genome-wide activity of its transcriptional network in skeletal muscle cells
- PGC-1α and IGFBP-5 expression in skeletal muscle of HF patients
- Neuronal activity controls the antagonistic between PGC-1α and SMRT in regulating antioxidant defences
- Combined Effect of Flow‐Mediated Shear Stress and Resveratrol on Sirt1/PGC‐1α Pathway in Vascular Endothelial Cells.
- Regulation of the metabolic coactivator PGC-1α by p160 myb binding protein and by the anaphase promoting complex
- Effect of PGC-1α on TNF-α-Induced MCP-1 and VCAM-1 Expression and NF-κB Activation in Human Aortic Smooth Muscle and Endothelial Cells
- The endothelial function under various blood glucose levels and the protective effect of PGC-1α on macrovasculature in patients with diabetes mellitus
- ERRα Agonists Regulate PGC-1α/ERRα Pathways in Mouse Myotubes Resulting in Enhanced Oxygen Consumption Rates.
- Exercise during pregnancy attenuates prenatal high‐fat diet‐induced hypermethylation of Pgc‐1α in skeletal muscle
- Estrogen‐Related Receptor α (ERRα) represses PGC‐1α‐activated PEPCK gene transcription
- Overexpression of PGC-1α in rat cardiomyocytes protects against nucleoside reverse transcriptase inhibitor (NRTI)-induced mitochondrial toxicity.
- Intense Physiological Light Upregulates VEGF and Promotes Choroidal Neovascularization via PGC-1α/ERR-α Pathway
- GW25-e0854 Atorvastatin Attenuates TNF-α-induced Increase of Glucose Oxidation Through PGC-1α Upregulation in cardiomyocytes
- Errα and Gabpa/b specify PGC-1α-dependent OXPHOS gene expression that is altered in diabetic muscle
- Protective Effect of Photoreceptor Outer Segments Phagocytosis for Retinal Pigment Epithelial Cells by PGC-1α/SIRT1
- PGC‐1α transfection restores early mitochondrial functional abnormalities in mdx skeletal muscle
- Reduced PGC-1α expression is associated with reduced respiratory capacity and substrate switching in unloaded rat heart
- Endurance exercise training protects skeletal muscle against doxorubicin‐induced damage via PGC‐1α‐mediated adaptations
- Identification of putative gene targets of PGC-1α in the brain: Insights into inhibitory neuron maturation, physiology, and behavior
- The endothelial function under various blood glucose levels and the protective effect of PGC-1α on macrovasculature in patients with diabetes mellitus
- PGC-1α synergizes ERRα to regulate transcription of mouse SHP in human hepatoma cells
- Mechanisms activating PGC-1α and consequential transcriptional mechanisms following exercise: A mini
- Effects of dietary flavonoids added to pharmacological antihypertensive therapy on PPARγ and PGC-1α gene expression.
- Erratum to ”Overexpression of PGC-1𝛼 Increases Fatty Acid Oxidative Capacity of Human Skeletal Muscle Cells”
- Amplification of PRDM16, BMP7, PPARα, COX II and PGC-1α Genes Tupaia belangeri
- Changes of PGC-1α and SIRT1 expression in hippocampus of type 2 diabetes mellitus rats and its significance
- Transcriptional peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1α) regulates transformation of muscle fiber type in Schizothorax prenanti
- Maternal low protein diet induces muscle mitochondrial respiration impairment, catch‐up growth and PGC‐1α expression (271.6)
- Investigating the Epigenetic Regulation of the BDNF, PGC-1α, Myogenin and MHC-IIb Genes
- Identification of cofactor network, including SIRT1 and SRC-3, which converges on energy expenditure through PGC-1α
- Redox imbalance activates PGC-1α-mediated mitochondrial antioxidant response during metabolic stress
- PGC-1α Mediates Anti-Remodeling Impact of cGMP-PDE5 Inhibitor in Failing Hearts
- Reduced Hepatic Mitochondrial Respiration following acute High-fat Diet is Prevented by PGC-1α Overexpression 2
- Increased PDK4 expression via PGC‐1α/ERRα–dependent mechanism in mouse skeletal muscle after high fat feeding
- Remodeling of calcium handling in skeletal muscle through the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α): Impact on force, fatigability …
- Cardiomyocyte Hypertrophy Induces O-linked-β-N-acetylglucosamine Modification of PGC-1α and Augments its Transcriptional Activity
- FGF21 deficiency exacerbates chronic alcohol induced fatty liver disease via a p38MAPK and PGC‐1α mediated pathway (653.13)
- Protective effects of liraglutide on main artery and expression of PGC-1α of liver in rats fed with promoting atherosclerosis diet.
- Partnership of HNF4α with the transcriptional coactivator PGC-1α in the regulation of hepatic glucose and lipid homeostasis
- Mitofusin 2 Gene Therapy Increases PGC-1α Expression in Pulmonary Artery Smooth Muscle Cells but Does Not Alter Mitochondrial Oxygen Consumption
- Quercetin can increase mRNA expression of PGC-1α and SIRT1, and mtDNA and cytochrome c in both skeletal muscle and brain.
- Adenosine prevents TNFα‐induced decrease in endothelial mitochondrial mass via activation of eNOS‐PGC‐1α regulatory axis (664.5)
- Omija Fruit Extract Improves Endurance and Energy Metabolism by Upregulating PGC-1α Expression in the Skeletal Muscle of Exercised Rats
- Opuntia humifusa Supplementation Reduces Fat Weight by Increasing PPAR-γ and PGC-1α Protein Expression in the Skeletal Muscle of Rats
- Mechanisms activating PGC-1α and consequential transcriptional mechanisms following exercise: A mini review (Early View)
- Effects of pretreatment with different doses of curcumin on expression of p-CREB and PGC-1α in hippocampus after global cerebral ischemia-reperfusion injury in rats
- A comparison of PGC-1α mRNA and protein expression in response to one week endurance training on alternate days or consecutive four days
- Co-ingestion of carbohydrate and whey protein isolates enhance PGC-1α mRNA expression: a randomised, single blind, cross over study
- CITED2 links hormonal signaling to PGC-1α acetylation in regulation of gluconeogenesis
- HIF‐1 independent COX‐2 and PGC‐1α pathways maintain brain angiogenic adptational change in aging mouse brain during chronic hypoxia
- … intensity-dependent regulation of mitochondrial respiration in human skeletal muscle: an effect modulated by the transcription factors PGC-1α, p53 and PHF20
- Mouse NTCP is directly transactivated via a conserved HNF-4α element in the proximal promoter region, with further co-activation by PGC-1α
- … ) inhibits chondrocyte catabolic response to pro-inflammatory cytokines and up-regulates anti-oxidant genes via PPARγ coactivator 1α (PGC-1α) and forkhead box O …
- Lipin 2 is a Liver‐enriched Coactivator of Peroxisome Proliferator‐activated Receptor γ (PPARγ) Coactivator‐1α (PGC‐1α) and Regulates Fatty Acid Metabolism in …
- Effects of core temperature on exercise-induced mitochondrial biogenesis: Potential role of PGC-1α, AMPK eNOS, SIRT1, and SIRT3
- The Corepressor NCoR1 Antagonizes PGC-1α and ERRα in the Regulation of Skeletal Muscle Function and Oxidative Metabolism.
- Suppression of gluconeogenesis in hepatocellular carcinoma by miR-23 directed downregulation of key gluconeogenic enzymes and the transcription factor PGC-1α
- Exercise-induced PGC-1α Expression does not Lower mtDNA Point Mutation Levels but Downregulates Tyrosine hydroxylase Expression in the Striatum
- Matched work high-intensity interval and continuous running induce similar 2 increases in PGC-1α mRNA, AMPK, p38 and p53 phosphorylation in human 3 skeletal …
- Metformin increases the PGC-1α protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo
- Mitochondrial Function/Dysfunction in Health and Disease: The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 …
- PGC-1α Overexpression Results in Increased Hepatic Fatty Acid Oxidation with Reduced Triacylglycerol Accumulation and Secretion 2
- Impact of Dicer on the Embryonic Stem Cell Epigenome and Androgen Mediated AMPK-PGC-1α Signaling in Prostate Cancer
- Changes in mRNA Expression of Peroxisome Proliferator-activated Receptor-γ Co-activator 1 (PGC-1α) in Different Tissues of OLETF Rats
- 3 MANUSCRIPT-2: ERRα as the major effector of gene program regulation by PGC-1α operates in presence and absence of PGC-1α to induce gene …
- PPARGC1A (PGC-1α) variation associated with DNA damage, diabetes and cardiovascular diseases: the Boston Puerto Rican Health Study
- Exercise during pregnancy attenuates prenatal high‐fat diet‐induced hypermethylation of the Pgc‐1α gene and protects against age‐induced glucose intolerance in …
- Genome-wide analysis of the transcriptional network controlled by PGC-1α and ERRα in skeletal muscle from microarray and next generation sequencing data
- PGC-1α increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4
- 4 MANUSCRIPT-3: Inhibition of cyclic nucleotide phosphodiesterase families does not enhance PGC-1α expression in mouse skeletal muscle
- Correction: Ethanol Suppresses PGC-1α Expression by Interfering with the cAMP-CREB Pathway in Neuronal Cells
- Hypoadiponectinemia-Induced Ampk-PGC-1α Signaling Impairment and Mitochondrial Biogenesis Dysfunction as a Novel Mechanism Responsible for Enhanced …
- … Ablation of Bach1 Plays an Important Role in Angiogenesis in A Mouse Hindlimb Ischemia Model through Increases in Expression of PGC-1α and Angiopoietin 1
- TP 37 Changes in muscle expression of PGC-1α and related signalling molecules in the mdx mouse: Possible impact on adaptive fiber phenotype transition and …
- Fibroblast Growth Factor-21 (FGF-21) enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons.
- High Volume Resistance Exercise Enhances PPARδ and PGC-1α Protein Expression, but not Mitochondrial Protein Synthesis in the Obese Zucker Rat.
- Fibroblast Growth Factor-21 (FGF-21) enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons.
- Description: PGC-1α (205–216), Proliferator-activated Receptor Coactivator-1 α (205–216)(AA: Ac-Arg-Pro-Cys-Ser-Glu-Leu-Leu-Lys-Tyr-Leu-Thr-Thr-NH2)(MW …
- An acute bout of high-intensity interval training increases the nuclear abundance 1 of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle 2 3 …
- Correction: Adenosine Prevents TNFα-Induced Decrease in Endothelial Mitochondrial Mass via Activation of eNOS-PGC-1α Regulatory Axis
- The association between PGC-1α and Alzheimer’s disease
- PGC-1α, glucose metabolism and type 2 diabetes mellitus
- PGC-1α as a pivotal factor in lipid and metabolic regulation
- PGC− 1α promoter methylation in Parkinson’s disease
- The hitchhiker’s guide to PGC-1α isoform structure and biological functions
- The metabolic modulator PGC-1α in cancer
- PPARγ and PGC-1α as therapeutic targets in Parkinson’s
- Metabolic roles of PGC-1α and its implications for type 2 diabetes
- The role of PGC-1α in the development of insulin resistance in skeletal muscle-revisited
- The role of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) in kidney disease
- Suppression of PGC-1α is critical for reprogramming oxidative metabolism in renal cell carcinoma
- PGC-1α and exercise intensity dependent adaptations in mouse skeletal muscle
- Melatonin prevents D rp1‐mediated mitochondrial fission in diabetic hearts through SIRT 1‐PGC 1α pathway
- Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle
- Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise
- PGC-1α modulates denervation-induced mitophagy in skeletal muscle
- Role of PGC-1α in vascular regulation: implications for atherosclerosis
- A map of the PGC-1α-and NT-PGC-1α-regulated transcriptional network in brown adipose tissue
- Selective chemical inhibition of PGC-1α gluconeogenic activity ameliorates type 2 diabetes
- Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 …
- Adult conditional knockout of PGC-1α leads to loss of dopamine neurons
- Metabolomic analysis of the skeletal muscle of mice overexpressing PGC-1α
- Effect of exercise training on skeletal muscle SIRT1 and PGC-1α expression levels in rats of different age
- PGC‐1α, a potential therapeutic target against kidney aging
- Sirtuin 1 activation enhances the PGC-1α/mitochondrial antioxidant system pathway in status epilepticus
- Regulation of mitochondrial biogenesis as a way for active longevity: interaction between the Nrf2 and PGC-1α signaling pathways
- PGC-1α promotes breast cancer metastasis and confers bioenergetic flexibility against metabolic drugs
- PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein
- PGC-1α sparks the fire of neuroprotection against neurodegenerative disorders
- Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
- PGC-1α induces human RPE oxidative metabolism and antioxidant capacity
- Impact of β-adrenergic signaling in PGC-1α-mediated adaptations in mouse skeletal muscle
- PGC‐1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI
- The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury
- MYC/PGC-1α balance determines the metabolic phenotype and plasticity of pancreatic cancer stem cells
- Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α
- PGC-1α protects from notch-induced kidney fibrosis development
- EglN2 associates with the NRF 1‐PGC 1α complex and controls mitochondrial function in breast cancer
- KDM3A senses oxygen availability to regulate PGC-1α-mediated mitochondrial biogenesis
- Resveratrol regulates microglia M1/M2 polarization via PGC-1α in conditions of neuroinflammatory injury
- Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
- Posttranslational regulation of PGC‐1α and its implication in cancer metabolism
- Coordination of mitochondrial biogenesis by PGC-1α in human skeletal muscle: A re-evaluation
- Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1α deacetylation
- ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling
- Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α‘
- Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α
- Exercise induces TFEB expression and activity in skeletal muscle in a PGC-1α-dependent manner
- PGC-1α dictates endothelial function through regulation of eNOS expression
- The role of alterations in mitochondrial dynamics and PGC‐1α over‐expression in fast muscle atrophy following hindlimb unloading
- Anti-fatigue effect of anwulignan via the NRF2 and PGC-1α signaling pathway in mice
- Protective role of PGC-1α in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling
- Mitochondrial quality control, promoted by PGC‐1α, is dysregulated by Western diet‐induced obesity and partially restored by moderate physical activity in mice
- Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibition
- Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder
- Role of PGC-1α in sarcopenia: etiology and potential intervention-a mini-review
- PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis
- PGC-1α modulates telomere function and DNA damage in protecting against aging-related chronic diseases
- Regulation of PGC-1α isoform expression in skeletal muscles
- Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE
- Micro RNA‐455 regulates brown adipogenesis via a novel HIF 1an‐AMPK‐PGC 1α signaling network
- PGC‐1α promotes exercise‐induced autophagy in mouse skeletal muscle
- Effect of thyme extract supplementation on lipid peroxidation, antioxidant capacity, PGC-1α content and endurance exercise performance in rats
- Role of PGC-1α in mitochondrial quality control in neurodegenerative diseases
- PGC-1α and PGC-1β increase protein synthesis via ERRα in C2C12 myotubes
- Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1/PGC-1α/Nrf2 pathway
- Chia (Salvia hispanica L.) enhances HSP, PGC-1α expressions and improves glucose tolerance in diet-induced obese rats
- Training intensity modulates changes in PGC‐1α and p53 protein content and mitochondrial respiration, but not markers of mitochondrial content in human skeletal …
- Mitochondrial dysfunction in Huntington’s disease; interplay between HSF1, p53 and PGC-1α transcription factors
- The role of PGC-1α/UCP2 signaling in the beneficial effects of physical exercise on the brain
- Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle
- The interaction of mitochondrial biogenesis and fission/fusion mediated by PGC-1α regulates rotenone-induced dopaminergic neurotoxicity
- Chlorpyrifos activates cell pyroptosis and increases susceptibility on oxidative stress‐induced toxicity by miR‐181/SIRT1/PGC‐1α/Nrf2 signaling pathway in human …
- Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα
- PGC-1α-mediated changes in phospholipid profiles of exercise-trained skeletal muscle
- Salidroside stimulates the Sirt1/PGC-1α axis and ameliorates diabetic nephropathy in mice
- Exercise training protects against aging-induced mitochondrial fragmentation in mouse skeletal muscle in a PGC-1α dependent manner
- PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
- Deposition of 5-methylcytosine on enhancer RNAs enables the coactivator function of PGC-1α
- MPC1 is essential for PGC-1α-induced mitochondrial respiration and biogenesis
- Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK/SIRT-1/PGC-1α pathway in diabetic kidney
- Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis
- SIRT3 protects cells from hypoxia via PGC-1α-and MnSOD-dependent pathways
- PGC-1α overexpression via local transfection attenuates mitophagy pathway in muscle disuse atrophy
- Epigenetic modifications of the PGC-1α promoter during exercise induced expression in mice
- FTO is required for myogenesis by positively regulating mTOR-PGC-1α pathway-mediated mitochondria biogenesis
- Effect of 12-weeks high-intensity interval training on SIRT1, PGC-1α and ERRα protein expression in aged rats
- The role of TLR4 on PGC-1α-mediated oxidative stress in tubular cell in diabetic kidney disease
- Isoform‐Specific SCFFbw7 Ubiquitination Mediates Differential Regulation of PGC‐1α
- SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during …
- Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons
- Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway
- PGC‐1α overexpression by in vivo transfection attenuates mitochondrial deterioration of skeletal muscle caused by immobilization
- SIRT1 facilitates hepatocellular carcinoma metastasis by promoting PGC-1α-mediated mitochondrial biogenesis
- Overexpression of PGC-1α influences mitochondrial signal transduction of dopaminergic neurons
- AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1α-mediated mitochondrial biogenesis
- PGC-1α controls skeletal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing TAZ
- Exercise prevents cardiac injury and improves mitochondrial biogenesis in advanced diabetic cardiomyopathy with PGC-1α and Akt activation
- C1q/TNF-related protein-9 ameliorates Ox-LDL-induced endothelial dysfunction via PGC-1α/AMPK-mediated antioxidant enzyme induction
- Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR‐α/sirtuin 1/PGC‐1α pathway
- Effects of exercise in a cold environment on transcriptional control of PGC-1α
- Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1α
- Calycosin-7-O-β-D-glucoside Attenuates OGD/R-Induced Damage by Preventing Oxidative Stress and Neuronal Apoptosis via the SIRT1/FOXO1/PGC-1α …
- Irisin reverses insulin resistance in C2C12 cells via the p38-MAPK-PGC-1α pathway
- Deciphering the dichotomous effects of PGC-1α on tumorigenesis and metastasis
- PGC-1α/ERRα-Sirt3 pathway regulates DAergic neuronal death by directly deacetylating SOD2 and ATP synthase β
- Overexpression of PGC‐1α in aging muscle enhances a subset of young‐like molecular patterns
- PGC-1α ameliorates kidney fibrosis in mice with diabetic kidney disease through an antioxidative mechanism
- Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD+-dependent SIRT1–PGC-1α–TFAM pathway
- Mitochondrial calcium uniporter regulates PGC-1α expression to mediate metabolic reprogramming in pulmonary fibrosis
- Anti-inflammatory action of β-hydroxybutyrate via modulation of PGC-1α and FoxO1, mimicking calorie restriction
- Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism
- Direct link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α
- Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway
- Salvianolic acid B improves mitochondrial function in 3T3-L1 adipocytes through a pathway involving PPARγ coactivator-1α (PGC-1α)
- The PGC-1α/ERRα axis represses one-carbon metabolism and promotes sensitivity to anti-folate therapy in breast cancer
- Role of microRNA-130b in placental PGC-1α/TFAM mitochondrial biogenesis pathway
- PPARβ is essential for maintaining normal levels of PGC-1α and mitochondria and for the increase in muscle mitochondria induced by exercise
- SIRT1/PGC-1α signaling promotes mitochondrial functional recovery and reduces apoptosis after intracerebral hemorrhage in rats
- Effect of contractile activity on PGC-1α transcription in young and aged skeletal muscle
- HDAC4 controls muscle homeostasis through deacetylation of myosin heavy chain, PGC-1α, and Hsc70
- … oxidative stress and apoptosis in podocytes via Sir2-related enzymes, sirtuins1 (SIRT1)/peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) …
- PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism
- Overexpression of PGC-1α increases peroxisomal activity and mitochondrial fatty acid oxidation in human primary myotubes
- The implication of PGC-1α on fatty acid transport across plasma and mitochondrial membranes in the insulin sensitive tissues
- Passive and post-exercise cold-water immersion augments PGC-1α and VEGF expression in human skeletal muscle
- Omega-3 fatty acids-enriched fish oil activates AMPK/PGC-1α signaling and prevents obesity-related skeletal muscle wasting
- Skeletal muscle-specific PGC-1α overexpression suppresses atherosclerosis in apolipoprotein E-knockout mice
- Swimming intervention mitigates HFD-induced obesity of rats through PGC-1α-irisin pathway.
- Dihydromyricetin improves skeletal muscle insulin sensitivity by inducing autophagy via the AMPK-PGC-1α-Sirt3 signaling pathway
- Cortical PGC-1α-dependent transcripts are reduced in postmortem tissue from patients with schizophrenia
- PGC-1α attenuates hydrogen peroxide-induced apoptotic cell death by upregulating Nrf-2 via GSK3β inactivation mediated by activated p38 in HK-2 Cells
- Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor
- The neuroprotective effect of tetramethylpyrazine against contusive spinal cord injury by activating PGC-1α in rats
- ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues
- Attenuated PGC-1α isoforms following endurance exercise with blood flow restriction
- High-fat diet inhibits PGC-1α suppressive effect on NFκB signaling in hepatocytes
- Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration
- The protective effects of salidroside from exhaustive exercise-induced heart injury by enhancing the PGC-1α–NRF1/NRF2 pathway and mitochondrial …
- Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC‐1α mediated attenuation of mitochondrial oxidative stress
- Skeletal muscle-specific overexpression of PGC-1α induces fiber-type conversion through enhanced mitochondrial respiration and fatty acid oxidation in mice …
- Dihydromyricetin stimulates irisin secretion partially via the PGC-1α pathway
- Isovitexin-mediated regulation of microglial polarization in lipopolysaccharide-induced neuroinflammation via activation of the CaMKKβ/AMPK-PGC-1α …
- Metformin‐induced autophagy and irisin improves INS‐1 cell function and survival in high‐glucose environment via AMPK/SIRT1/PGC‐1α signal pathway
- Sestrin2 silencing exacerbates cerebral ischemia/reperfusion injury by decreasing mitochondrial biogenesis through the AMPK/PGC-1α pathway in rats
- Lactate administration increases mRNA expression of PGC-1α and UCP3 in mouse skeletal muscle
- PGC-1α protects RPE cells of the aging retina against oxidative stress-induced degeneration through the regulation of senescence and mitochondrial quality …
- Baicalin ameliorates hepatic insulin resistance and gluconeogenic activity through inhibition of p38 MAPK/PGC-1α pathway
- Obesity-associated miR-199a/214 cluster inhibits adipose browning via PRDM16–PGC-1α transcriptional network
- Epoxyeicosatrienoic acids regulate adipocyte differentiation of mouse 3T3 cells, via PGC-1α activation, which is required for HO-1 expression and increased …
- Apolipoprotein E regulates mitochondrial function through the PGC-1α-sirtuin 3 pathway
- Sprint-interval but not continuous exercise increases PGC-1α protein content and p53 phosphorylation in nuclear fractions of human skeletal muscle
- PGC‐1α affects aging‐related changes in muscle and motor function by modulating specific exercise‐mediated changes in old mice
- Carbon Monoxide Potentiation of L-Type Ca2+ Channel Activity Increases HIF-1α-Independent VEGF Expression via an AMPKα/SIRT1-Mediated PGC-1α/ERRα …
- Quercetin ameliorates hypobaric hypoxia-induced memory impairment through mitochondrial and neuron function adaptation via the PGC-1α pathway
- MiR-485-3p and miR-485-5p suppress breast cancer cell metastasis by inhibiting PGC-1α expression
- N6‐methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO‐PGC‐1α signalling axis
- PGC-1α repression and high-fat diet induce age-related macular degeneration-like phenotypes in mice
- TFEB drives PGC-1α expression in adipocytes to protect against diet-induced metabolic dysfunction
- Time-dependent changes in increased levels of plasma irisin and muscle PGC-1α and FNDC5 after exercise in mice
- Time since menopause and skeletal muscle estrogen receptors, PGC-1α, and AMPK
- Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
- The AMPK-PGC-1α signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury
- Endoplasmic reticulum stress-induced CHOP inhibits PGC-1α and causes mitochondrial dysfunction in diabetic embryopathy
- Resveratrol regulates skeletal muscle fibers switching through the AdipoR1-AMPK-PGC-1α pathway
- PGC‐1α and fasting‐induced PDH regulation in mouse skeletal muscle
- Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway
- Oxidative stress induces loss of pericyte coverage and vascular instability in PGC-1α-deficient mice
- Pathological remodeling of the myocardium in chronic heart failure: role of PGC-1α
- BPA-induced DNA hypermethylation of the master mitochondrial gene PGC-1α contributes to cardiomyopathy in male rats
- Effect of PGC-1α overexpression or silencing on mitochondrial apoptosis of goat luteinized granulosa cells
- Postinfarction exercise training alleviates cardiac dysfunction and adverse remodeling via mitochondrial biogenesis and SIRT1/PGC‐1α/PI3K/Akt signaling
- GLP-1 contributes to increases in PGC-1α expression by downregulating miR-23a to reduce apoptosis
- Activation of FoxO1/PGC-1α prevents mitochondrial dysfunction and ameliorates mesangial cell injury in diabetic rats
- PGC-1α regulates the cell cycle through ATP and ROS in CH1 cells
- Astragaloside IV protects against isoproterenol-induced cardiac hypertrophy by regulating NF-κB/PGC-1α signaling mediated energy biosynthesis
- Glucocorticoids alter CRTC-CREB signaling in muscle cells: impact on PGC-1α expression and atrophy markers
- Adaptation of skeletal muscles to contractile activity of varying duration and intensity: the role of PGC-1α
- An emerging role for epigenetic regulation of PGC-1α expression in environmentally stimulated brown adipose thermogenesis
- Effects of PPARα/PGC-1α on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes in vitro
- Upregulation of skeletal muscle PGC-1α through the elevation of cyclic AMP levels by Cyanidin-3-glucoside enhances exercise performance
- MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α
- Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice
- Cerebrolysin Ameliorates Focal Cerebral Ischemia Injury Through Neuroinflammatory Inhibition via CREB/PGC-1α Pathway
- Dexmedetomidine reduces oxidative stress and provides neuroprotection in a model of traumatic brain injury via the PGC-1α signaling pathway
- Dihydromyricetin attenuates dexamethasone-induced muscle atrophy by improving mitochondrial function via the PGC-1α pathway
- Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation
- Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
- Suppression of endothelial PGC-1α is associated with hypoxia-induced endothelial dysfunction and provides a new therapeutic target in pulmonary arterial …
- PGC-1α coordinates mitochondrial respiratory capacity and muscular fatty acid uptake via regulation of VEGF-B
- Obesity causes PGC‐1α deficiency in the pancreas leading to marked IL‐6 upregulation via NF‐κB in acute pancreatitis
- PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle
- Increased FXYD1 and PGC‐1α mRNA after blood flow‐restricted running is related to fibre type‐specific AMPK signalling and oxidative stress in human muscle
- Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1–40/42 and Phospho-Tau May Abet …
- Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1α signaling pathway
- PGC-1α activation: a therapeutic target for type 2 diabetes?
- Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson’s disease
- Modulation of apoptosis by sulforaphane is associated with PGC-1α stimulation and decreased oxidative stress in cardiac myoblasts
- Up‐regulation of PGC‐1α in neurons protects against experimental autoimmune encephalomyelitis
- A comparative study on the effects of high-fat diet and endurance training on the PGC-1α-FNDC5/irisin pathway in obese and nonobese male C57BL/6 mice
- Resveratrol prevents ROS-induced apoptosis in high glucose-treated retinal capillary endothelial cells via the activation of AMPK/Sirt1/PGC-1α pathway
- SIRT1/PGC-1α signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids
- PGC-1α as a Biomarker of Physical Activity-Protective Effect on Colorectal CancerPGC-1α in the Physical Activity–Protective Effect on CRC
- A novel danshensu-tetramethylpyrazine conjugate DT-010 provides cardioprotection through the PGC-1α/Nrf2/HO-1 pathway
- … ameliorates amyloid-β-induced learning and memory impairment, possibly via increasing AMPK activity and up-regulation of the PGC-1α/FNDC5/BDNF pathway
- Downregulation of PGC-1α prevents the beneficial effect of EET-heme oxygenase-1 on mitochondrial integrity and associated metabolic function in obese …
- Glycyrrhizic acid prevents diabetic nephropathy by activating AMPK/SIRT1/PGC-1α signaling in db/db mice
- Exploring the role of PGC‐1α in defining nuclear organisation in skeletal muscle fibres
- Telomere dysfunction disturbs macrophage mitochondrial metabolism and the NLRP3 inflammasome through the PGC-1α/TNFAIP3 axis
- Grape seed procyanidin B2 protects podocytes from high glucose-induced mitochondrial dysfunction and apoptosis via the AMPK-SIRT1-PGC-1α axis in vitro
- Exercise training protects against aging-induced cognitive dysfunction via activation of the hippocampal PGC-1α/FNDC5/BDNF pathway
- Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway
- PGC-1α regulates alanine metabolism in muscle cells
- Lentivirus-mediated PGC-1α overexpression protects against traumatic spinal cord injury in rats
- Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/-mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of …
- Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection
- Poly (ADP-ribose) polymerase-1 inhibits mitochondrial respiration by suppressing PGC-1α activity in neurons
- Electroacupuncture upregulates SIRT1-dependent PGC-1α expression in SAMP8 mice
- Impact of adrenaline and metabolic stress on exercise‐induced intracellular signaling and PGC‐1α mRNA response in human skeletal muscle
- Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant …
- Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway
- PGC-1α controls mitochondrial biogenesis in drug-resistant colorectal cancer cells by regulating endoplasmic reticulum stress
- Rapidly elevated levels of PGC-1α-b protein in human skeletal muscle after exercise: exploring regulatory factors in a randomized controlled trial
- Curcumin attenuates skeletal muscle mitochondrial impairment in COPD rats: PGC-1α/SIRT3 pathway involved
- SIRT1 prevents hyperuricemia via the PGC-1α/PPARγ-ABCG2 pathway
- Quercetin improve ischemia/reperfusion‐induced cardiomyocyte apoptosis in vitro and in vivo study via SIRT1/PGC‐1α signaling
- Sodium bicarbonate ingestion augments the increase in PGC-1α mRNA expression during recovery from intense interval exercise in human skeletal muscle
- Hypoxia-induced PGC-1α regulates mitochondrial function and tumorigenesis of colorectal cancer cells
- Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche
- Altered expression of PGC-1α and PDX1 and their methylation status are associated with fetal glucose metabolism in gestational diabetes mellitus
- Adult expression of PGC-1α and-1β in skeletal muscle is not required for endurance exercise-induced enhancement of exercise capacity
- Neuroprotection by quercetin via mitochondrial function adaptation in traumatic brain injury: PGC‐1α pathway as a potential mechanism
- Moderate modulation of cardiac PGC-1α expression partially affects age-associated transcriptional remodeling of the heart
- Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis
- Interaction of CREB and PGC-1α induces fibronectin type III domain-containing protein 5 expression in C2C12 myotubes
- Globular CTRP3 promotes mitochondrial biogenesis in cardiomyocytes through AMPK/PGC-1α pathway
- PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy
- PPARγ coactivator-1α (PGC-1α) protects neuroblastoma cells against amyloid-beta (Aβ) induced cell death and neuroinflammation via NF-κB pathway
- Cisplatin enhances hepatitis B virus replication and PGC-1α expression through endoplasmic reticulum stress
- Peroxisome proliferator-activated receptor-γ (PPARγ) agonist is neuroprotective and stimulates PGC-1α expression and CREB phosphorylation in human …
- Butyrate promotes slow-twitch myofiber formation and mitochondrial biogenesis in finishing pigs via inducing specific microRNAs and PGC-1α expression
- Pharmaceutical Induction of PGC-1α Promotes Retinal Pigment Epithelial Cell Metabolism and Protects against Oxidative Damage
- Essential role of the PGC‐1α/PPARβ axis in Ucp3 gene induction
- l‐Citrulline Supplementation‐Increased Skeletal Muscle PGC‐1α Expression Is Associated with Exercise Performance and Increased Skeletal Muscle Weight
- Muscle-specific overexpression of PGC-1α does not augment metabolic improvements in response to exercise and caloric restriction
- Heart specific PGC-1α deletion identifies metabolome of cardiac restricted metabolic heart failure
- How epigenetic modifications drive the expression and mediate the action of PGC-1α in the regulation of metabolism
- PGC-1α overexpression partially rescues impaired oxidative and contractile pathophysiology following volumetric muscle loss injury
- PGC-1α may associated with the anti-obesity effect of taurine on rats induced by arcuate nucleus lesion
- Gly482Ser PGC-1α gene polymorphism and exercise-related oxidative stress in amyotrophic lateral sclerosis patients
- Hepatic oleate regulates liver stress response partially through PGC-1α during high-carbohydrate feeding
- Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP
- Improved skeletal muscle Ca2+ regulation in vivo following contractions in mice overexpressing PGC-1α
- … against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1α …
- Mitochondrial aldehyde dehydrogenase obliterates insulin resistance-induced cardiac dysfunction through deacetylation of PGC-1α
- Acute upregulation of PGC-1α mRNA correlates with training-induced increases in SDH activity in human skeletal muscle
- Super-enhancers define a proliferative PGC-1α-expressing melanoma subgroup sensitive to BET inhibition
- CTRP9 induces mitochondrial biogenesis and protects high glucose-induced endothelial oxidative damage via AdipoR1-SIRT1-PGC-1α activation
- Resistance exercise with low glycogen increases p53 phosphorylation and PGC-1α mRNA in skeletal muscle
- The PGC-1α activator ZLN005 ameliorates ischemia-induced neuronal injury in vitro and in vivo
- Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-α/PGC-1α signaling mediated energy biosynthesis
- Transcriptional control, but not subcellular location, of PGC-1α is altered following exercise in a hot environment
- Regulation of endothelial dynamics by PGC-1α relies on ROS control of VEGF-A signaling
- Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells
- ZL006 protects spinal cord neurons against ischemia-induced oxidative stress through AMPK-PGC-1α-Sirt3 pathway
- The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1α signaling
- Aerobic exercise recovers disuse-induced atrophy through the stimulus of the LRP130/PGC-1α complex in aged rats
- The PPARGC1A locus and CNS-specific PGC-1α isoforms are associated with Parkinson’s Disease
- Enhancement of glucose metabolism via PGC-1α participates in the cardioprotection of chronic intermittent hypobaric hypoxia
- Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1α pathway
- PGC-1α, sirtuins and PARPs in Huntington’s disease and other neurodegenerative conditions: NAD+ to rule them all
- Mutual antagonism of PINK1/Parkin and PGC-1α contributes to maintenance of mitochondrial homeostasis in rotenone-induced neurotoxicity
- Hepatic stearoyl CoA desaturase 1 deficiency increases glucose uptake in adipose tissue partially through the PGC-1α–FGF21 axis in mice
- Carbon monoxide stimulates astrocytic mitochondrial biogenesis via L-type Ca2+ channel-mediated PGC-1α/ERRα activation
- Inhibition of miR-23a attenuates doxorubicin-induced mitochondria-dependent cardiomyocyte apoptosis by targeting the PGC-1α/Drp1 pathway
- Sodium azide induces mitochondria‑mediated apoptosis in PC12 cells through PGC-1α‑associated signaling pathway
- Hepatic Stearoyl-CoA desaturase-1 deficiency-mediated activation of mTORC1-PGC-1α axis regulates ER stress during high-carbohydrate feeding
- Postexercise cold water immersion modulates skeletal muscle PGC-1α mRNA expression in immersed and nonimmersed limbs: evidence of systemic regulation
- Resveratrol rescues cadmium-induced mitochondrial injury by enhancing transcriptional regulation of PGC-1α and SOD2 via the Sirt3/FoxO3a pathway in TCMK-1 …
- The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti …
- PGC-1α downregulation in steatotic liver enhances ischemia-reperfusion injury and impairs ischemic preconditioning
- miR-29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1α signaling: Implications for age-related hearing loss …
- PGC-1α overexpression protects against aldosterone-induced podocyte depletion: role of mitochondria
- MALAT1 up-regulator polydatin protects brain microvascular integrity and ameliorates stroke through C/EBPβ/MALAT1/CREB/PGC-1α/PPARγ pathway
- Lixisenatide enhances mitochondrial biogenesis and function through regulating the CREB/PGC-1α pathway
- Conjugated linoleic acid (CLA) stimulates mitochondrial biogenesis signaling by the upregulation of PPARγ coactivator 1α (PGC-1α) in C2C12 cells
- Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway
- Glia maturation factor dependent inhibition of mitochondrial PGC-1α triggers oxidative stress-mediated apoptosis in N27 rat dopaminergic neuronal cells
- PGC-1α over-expression suppresses the skeletal muscle atrophy and myofiber-type composition during hindlimb unloading
- Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions
- The effect of acute and chronic sprint‐interval training on LRP130, SIRT3, and PGC‐1α expression in human skeletal muscle
- Treatment with celastrol protects against obesity through suppression of galanin-induced fat intake and activation of PGC-1α/GLUT4 axis-mediated glucose …
- miR449a/SIRT1/PGC-1α is necessary for mitochondrial biogenesis induced by T-2 toxin
- PGC-1α (peroxisome proliferator–activated receptor γ coactivator 1-α) overexpression in coronary artery disease recruits NO and hydrogen peroxide during flow …
- Protective effects of PGC-1α against lead-induced oxidative stress and energy metabolism dysfunction in testis Sertoli cells
- Regulation of brown and white adipocyte transcriptome by the transcriptional coactivator NT-PGC-1α
- Formononetin ameliorates cognitive disorder via PGC-1α pathway in neuroinflammation conditions in high-fat diet-induced mice
- Resistin destroys mitochondrial biogenesis by inhibiting the PGC-1α/NRF1/TFAM signaling pathway
- Pathophysiological mechanism of bone loss in type 2 diabetes involves inverse regulation of osteoblast function by PGC-1α and skeletal muscle atrogenes: AdipoR1 …
- PGC‐1α mediates a rapid, exercise‐induced downregulation of glycogenolysis in rat skeletal muscle
- … biogenesis and protects against seizure-induced neuronal cell damage in the hippocampus following status epilepticus by activation of the PGC-1α signaling …
- PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts
- αvβ5 integrin/FAK/PGC-1α pathway confers protective effects on retinal pigment epithelium
- PGC-1α participates in the protective effect of chronic intermittent hypobaric hypoxia on cardiomyocytes
- Effect of MPTP on mRNA expression of PGC-1α in mouse brain
- Resveratrol ameliorates contrast induced nephropathy through the activation of SIRT1-PGC-1α-Foxo1 signaling in mice
- Aerobic training increases expression levels of SIRT3 and PGC-1α in skeletal muscle of overweight adolescents without change in caloric intake
- Oxidative and energetic stresses mediate beta-cell dysfunction induced by PGC-1α
- PGC-1α promotes ureagenesis in mouse periportal hepatocytes through SIRT3 and SIRT5 in response to glucagon
- Combined speed endurance and endurance exercise amplify the exercise‐induced PGC‐1α and PDK4 mRNA response in trained human muscle
- Beneficial effects of PGC-1α in the substantia nigra of a mouse model of MPTP-induced dopaminergic neurotoxicity
- Vinegar decreases blood pressure by down-regulating AT1R expression via the AMPK/PGC-1α/PPARγ pathway in spontaneously hypertensive rats
- Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1α, p53, and DNA damage. A hypothesis
- The methionine transamination pathway controls hepatic glucose metabolism through regulation of the GCN5 acetyltransferase and the PGC-1α …
- Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis
- Exercise training‐induced improvement in skeletal muscle PGC‐1α‐mediated fat metabolism is independent of dietary glycemic index
- Mutual exacerbation of PGC-1α deregulation and α-synuclein oligomerization
- Exercise duration-matched interval and continuous sprint cycling induce similar increases in AMPK phosphorylation, PGC-1α and VEGF mRNA expression in …
- Activating the PGC-1α/TERT pathway by catalpol ameliorates atherosclerosis via modulating ROS production, DNA damage, and telomere function …
- … effects of compatibility of Aconiti Lateralis Radix Praeparata and Zingiberis Rhizoma on rats with heart failure by enhancing mitochondrial biogenesis via Sirt1/PGC-1α …
- Resistin regulates fatty acid Β oxidation by suppressing expression of peroxisome proliferator activator receptor gamma-coactivator 1α (PGC-1α)
- The Gly482Ser polymorphism of the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is associated with type 2 diabetes in Tunisian population
- PGC-1α or FNDC5 Is Involved in Modulating the Effects of Aβ1−42 Oligomers on Suppressing the Expression of BDNF, a Beneficial Factor for Inhibiting …
- Amelioration of Huntington’s disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1α …
- Cell-specific deletion of PGC-1α from medium spiny neurons causes transcriptional alterations and age-related motor impairment
- Protective effects of PGC-1α via the mitochondrial pathway in rat brains after intracerebral hemorrhage
- Ampelopsin attenuates the atrophy of skeletal muscle from d-gal-induced aging rats through activating AMPK/SIRT1/PGC-1α signaling cascade
- TWEAK/Fn14 promotes oxidative stress through AMPK/PGC-1α/MnSOD signaling pathway in endothelial cells
- PGC-1α–FNDC5–BDNF signaling pathway in skeletal muscle confers resilience to stress in mice subjected to chronic social defeat
- The effects of high-intensity interval training vs. moderate-intensity continuous training on serum irisin and expression of skeletal muscle PGC-1α gene in male rats
- Pyrroloquinoline quinone resists denervation-induced skeletal muscle atrophy by activating PGC-1α and integrating mitochondrial electron transport chain …
- Bhlhe40 represses PGC-1α activity on metabolic gene promoters in myogenic cells
- BPDE and B [a] P induce mitochondrial compromise by ROS-mediated suppression of the SIRT1/TERT/PGC-1α pathway in spermatogenic cells both in vitro and in …
- PGC-1α in aging and lifelong exercise training-mediated regulation of UPR in mouse liver
- Gpbar1 agonism promotes a PGC-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice
- High-intensity high-volume swimming induces more robust signaling through PGC-1α and AMPK activation than sprint interval swimming in m. triceps brachii
- spargel, the PGC-1α homologue, in models of Parkinson disease in Drosophila melanogaster
- PGC-1α limits angiotensin II-induced rat vascular smooth muscle cells proliferation via attenuating NOX1-mediated generation of reactive oxygen species
- … and Glycolipid Metabolism of Blunt Snout Bream Megalobrama amblycephala Fed High-Carbohydrate Diets by Activating the AMPK–SIRT1–PGC-1α …
- … in metabolic organs and modulate systemic parameters independently of skeletal muscle peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α …
- Sestrin2 facilitates glutamine‐dependent transcription of PGC‐1α and survival of liver cancer cells under glucose limitation
- Reversal of defective mitochondrial biogenesis in limb-girdle muscular dystrophy 2D by independent modulation of histone and PGC-1α acetylation
- δ-Tocopherol promotes thermogenic gene expression via PGC-1α upregulation in 3T3-L1 cells
- Deciphering the molecular mechanism during doxorubicin-mediated oxidative stress, apoptosis through Nrf2 and PGC-1α in a rat testicular milieu
- Metabolic regulation by the PGC-1α and PGC-1β coactivators in larval zebrafish (Danio rerio)
- Green Tea (−)-Epigallotocatechin-3-Gallate induces PGC-1α gene expression in HepG2 cells and 3T3-L1 adipocytes
- A PGC-1α-mediated transcriptional network maintains mitochondrial redox and bioenergetic homeostasis against doxorubicin-induced toxicity in human …
- Glucose restriction promotes osteocyte specification by activating a PGC-1α-dependent transcriptional program
- Kavain reduces Porphyromonas gingivalis–induced adipocyte inflammation: Role of PGC-1α signaling
- Thymoquinone inhibits angiotensin II-induced proliferation and migration of vascular smooth muscle cells through the AMPK/PPARγ/PGC-1α pathway
- Adipose triglyceride lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response
- PGC-1α-dependent mitochondrial adaptation is necessary to sustain IL-2-induced activities in human NK cells
- Overexpression of PGC-1α enhances cell proliferation and tumorigenesis of HEK293 cells through the upregulation of Sp1 and Acyl-CoA binding protein
- Ropivacaine impairs mitochondrial biogenesis by reducing PGC-1α
- Effects of eicosapentaenoic acid and docosahexaenoic acid on mitochondrial DNA replication and PGC-1α gene expression in C2C12 muscle cells
- PGC-1α-mediated mitochondrial biogenesis is involved in cannabinoid receptor 2 agonist AM1241-induced microglial phenotype amelioration
- Tetrahydroxystilbene glucoside delayed senile symptoms in old mice via regulation of the AMPK/SIRT1/PGC-1α signaling cascade
- PGC-1α and Nr4a1 are target genes of circadian melatonin and dopamine release in murine retina
- Antifibrotic role of PGC-1α-siRNA against TGF-β1-induced renal interstitial fibrosis
- Muscle type-specific RNA polymerase II recruitment during PGC-1α gene transcription after acute exercise in adult rats
- … with endoplasmic reticulum stress alleviated heart ischemia/reperfusion injury via modulating IRE1/ATF6/RACK1/PERK and PGC-1α in diabetes mellitus
- Quercetin induces mitochondrial biogenesis in experimental traumatic brain injury via the PGC-1α signaling pathway
- Yiqihuoxue decoction protects against post-myocardial infarction injury via activation of cardiomyocytes PGC-1α expression
- The single nucleotide polymorphism Gly482Ser in the PGC-1α gene impairs exercise-induced slow-twitch muscle fibre transformation in humans
- PPARγ/PGC-1α-Fndc5 pathway up-regulation in gastrocnemius and heart muscle of exercised, branched chain amino acid diet fed mice
- Atorvastatin attenuates myocardial hypertrophy in spontaneously hypertensive rats via the C/EBPβ/PGC-1α/UCP3 pathway
- Effect of electroacupuncture combined with treadmill exercise on body weight and expression of PGC-1α, Irisin and AMPK in skeletal muscle of diet-induced obesity …
- Dehydroepiandrosterone activates AMP kinase and regulates GLUT4 and PGC-1α expression in C2C12 myotubes
- PGC-1α in exercise and fasting-induced regulation of hepatic UPR in mice
- Protective effects of exogenous NaHS against sepsis-induced myocardial mitochondrial injury by enhancing the PGC-1α/NRF2 pathway and mitochondrial …
- Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance
- Sitagliptin promotes mitochondrial biogenesis in human SH‐SY5Y cells by increasing the expression of PGC‐1α/NRF1/TFAM
- A peptide isolated from Hippocampus abdominalis improves exercise performance and exerts anti-fatigue effects via AMPK/PGC-1α pathway in mice
- Effect of resistance exercise intensity on the expression of PGC-1α isoforms and the anabolic and catabolic signaling mediators, IGF-1 and myostatin, in human …
- Chikusetsu saponin V attenuates H2O2-induced oxidative stress in human neuroblastoma SH-SY5Y cells through Sirt1/PGC-1α/Mn-SOD signaling pathways
- Mild aerobic training with blood flow restriction increases the hypertrophy index and MuSK in both slow and fast muscles of old rats: Role of PGC-1α
- Prep1 regulates angiogenesis through a PGC‐1α‐mediated mechanism
- PGC‐1α inhibits polyamine metabolism in Cyclin E1‐driven ovarian cancer
- PGC-1α protects against oxidized low-density lipoprotein and luteinizing hormone-induced granulosa cells injury through ROS-p38 pathway
- Epigallocatechin gallate reduces slow-twitch muscle fiber formation and mitochondrial biosynthesis in C2C12 cells by repressing AMPK activity and PGC-1α …
- MicroRNA-19b/221/222 induces endothelial cell dysfunction via suppression of PGC-1α in the progression of atherosclerosis
- Loss of renal tubular PGC-1α exacerbates diet-induced renal steatosis and age-related urinary sodium excretion in mice
- Liquiritigenin protects rats from carbon tetrachloride induced hepatic injury through PGC-1α pathway
- HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1α promoter
- The genomic context and corecruitment of SP1 affect ERRα coactivation by PGC-1α in muscle cells
- Disruption of peroxisome proliferator–activated receptor γ coactivator (PGC)-1α reverts key features of the neoplastic phenotype of glioma cells
- Expression of fatty acid synthase is regulated by PGC-1α and contributes to increased cell proliferation
- Triptolide improves cognitive dysfunction in rats with vascular dementia by activating the SIRT1/PGC-1α signaling pathway
- CTRP9 ameliorates cellular senescence via PGC-1α/AMPK signaling in mesenchymal stem cells
- Response of BAX, Bcl-2 proteins, and SIRT1/PGC-1α mRNA expression to 8-week treadmill running in the aging rat skeletal muscle
- Transcriptional coactivator NT‐PGC‐1α promotes gluconeogenic gene expression and enhances hepatic gluconeogenesis
- Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1α Promoter Activity
- CTRP3 promotes energy production by inducing mitochondrial ROS and up-expression of PGC-1α in vascular smooth muscle cells
- Interleukin 6 modulates PPARα and PGC-1α and is involved in high-fat diet induced cardiac lipotoxicity in mouse
- AMPK activation of PGC-1α/NRF-1-dependent SELENOT gene transcription promotes PACAP-induced neuroendocrine cell differentiation through tolerance to …
- A single bout of whole‐leg, peristaltic pulse external pneumatic compression upregulates PGC‐1α mRNA and endothelial nitric oxide sythase protein in human …
- Endurance exercise resistance to lipotoxic cardiomyopathy is associated with cardiac NAD+/dSIR2/PGC-1α pathway activation in old Drosophila
- PGC-1α Suppresses the Activation of TGF-β/Smad Signaling via Targeting TGFβRI Downregulation by let-7b/c Upregulation
- Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats …
- Arsenic-induced mitochondrial oxidative damage is mediated by decreased PGC-1α expression and its downstream targets in rat brain
- … and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1‐mediated deacetylation of FXR and PGC‐1α
- Traditional Chinese medicine Qiliqiangxin attenuates phenylephrine-induced cardiac hypertrophy via upregulating PPARγ and PGC-1α
- Gluconeogenesis, lipogenesis, and HBV replication are commonly regulated by PGC-1α-dependent pathway
- Montelukast promotes mitochondrial biogenesis via CREB/PGC-1α in human bronchial epithelial cells
- PGC-1α expression in murine AgRP neurons regulates food intake and energy balance
- Systematic meta-analysis revealed an association of PGC-1α rs8192678 polymorphism in type 2 diabetes mellitus
- The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1-and PGC-1α-mediated regulation of Glut2
- d-Fagomine Attenuates High Glucose-Induced Endothelial Cell Oxidative Damage by Upregulating the Expression of PGC-1α
- PGC‐1α in Melanoma: A Key Factor for Antioxidant Response and Mitochondrial Function
- … Accumulation, Mitochondrial Dysfunction, and Insulin Resistance in Skeletal Muscle of Ageing Rats: Dual Stimulation of the AMPK/PGC‐1α Signaling Pathway via …
- KLF5 overexpression attenuates cardiomyocyte inflammation induced by oxygen-glucose deprivation/reperfusion through the PPARγ/PGC-1α/TNF-α signaling …
- Metformin increases cardiac rupture after myocardial infarction via the AMPK-MTOR/PGC-1α signaling pathway in rats with acute myocardial infarction
- More than mitochondrial biogenesis: alternative roles of PGC-1α in exercise adaptation
- Relationship of PGC-1α gene polymorphism with insulin resistance syndrome in Korean children
- High glucose and free fatty acids induce endothelial progenitor cell senescence via PGC‐1α/SIRT1 signaling pathway
- An unexpected role for the transcriptional coactivator isoform NT-PGC-1α in the regulation of mitochondrial respiration in brown adipocytes
- PGC-1α is responsible for survival of multiple myeloma cells under hyperglycemia and chemotherapy
- Deletion of the transcription factor PGC-1α in mice negatively regulates bone mass
- PGC-1α silencing compounds the perturbation of mitochondrial function caused by mutant SOD1 in skeletal muscle of ALS mouse model
- PGC‐1α/SNAI1 axis regulates tumor growth and metastasis by targeting miR‐128b in gastric cancer
- Expression of the gene coading for PGC-1α in peripheral blood leukocytes and related gene variants in patients with Parkinson’s disease
- Eccentric resistance training and β-hydroxy-β-methylbutyrate free acid affects muscle PGC-1α expression and serum irisin, nesfatin-1 and resistin in rats
- mRNA expression levels of PGC-1α in a transgenic and a toxin model of Huntington’s disease
- The role of PGC-1α and MRP1 in lead-induced mitochondrial toxicity in testicular Sertoli cells
- Muscle PGC-1α is required for long-term systemic and local adaptations to a ketogenic diet in mice
- Quercetin and quercetin-rich red onion extract alter PGC-1α promoter methylation and splice variant expression
- Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression
- Overexpression of NAD (P) H: quinone oxidoreductase 1 inhibits hepatocellular carcinoma cell proliferation and induced apoptosis by activating AMPK/PGC-1α …
- … and memory in scopolamine-treated mice by reducing acetylcholinesterase activity and attenuating oxidative damage through SIRT1-PGC-1α-Tau signaling pathway
- NT-PGC-1α deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo
- Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1α-UCP2 axis
- Cardiomyocytes are protected from antiretroviral nucleoside analog-induced mitochondrial toxicity by overexpression of PGC-1α
- Supplementation with an insoluble fiber obtained from carob pod (Ceratonia siliqua L.) rich in polyphenols prevents dyslipidemia in rabbits through SIRT1/PGC-1α …
- Interaction effect of PGC-1α rs10517030 variants and energy intake in the risk of type 2 diabetes in middle-aged adults
- Alteration of muscle fiber characteristics and the AMPK-SIRT1-PGC-1α axis in skeletal muscle of growing pigs fed low-protein diets with varying branched …
- The effects of PGC-1α on the proliferation and energy metabolism of malignant endometrial cancer cells
- Lutein upregulates the PGC‐1α, NRF1, and TFAM expression by AMPK activation and downregulates ROS to maintain mtDNA integrity and mitochondrial biogenesis …
- RETRACTED ARTICLE: MiR-138-5p exacerbates hypoxia/reperfusion-induced heart injury through the inactivation of SIRT1-PGC-1α
- Low-intensity exercise in the acute phase of lipopolysaccharide-induced sepsis improves lipid metabolism and survival in mice by stimulating PGC-1α expression
- Association of combined genetic variations in PPARγ, PGC-1α, and LXRα with coronary artery disease and severity in Thai population
- Mice Lacking the Transcriptional Coactivator PGC-1α Exhibit Hyperactivity
- trans-Cinnamaldehyde stimulates mitochondrial biogenesis through PGC-1α and PPARβ/δ leading to enhanced GLUT4 expression
- Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals: implication in obesity-induced disease
- miR-696 plays a role in hepatic gluconeogenesis in ob/ob mice by targeting PGC-1α
- Gastric bypass surgery improves the skeletal muscle ceramide/S1P ratio and upregulates the AMPK/SIRT1/PGC-1α pathway in Zucker diabetic fatty rats
- Nitrosporeusine A attenuates sepsis-associated acute kidney injury through the downregulation of IL-6/sIL-6R axis activation-mediated PGC-1α suppression
- PGC-1α overexpression suppresses blood pressure elevation in DOCA-salt hypertensive mice
- Thyroid hormone induces PGC-1α during dendritic outgrowth in mouse cerebellar Purkinje cells
- Effects of diet and arginine treatment during the luteal phase on ovarian NO/PGC-1α signaling in ewes
- Cardiac differentiation of mouse embryonic stem cells is influenced by a PPAR γ/PGC-1α—FNDC5 pathway during the stage of cardiac precursor cell formation
- BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic …
- Browning of pig white preadipocytes by co-overexpressing pig PGC-1α and mice UCP1
- Improved endogenous epoxyeicosatrienoic acid production mends heart function via increased PGC 1α-mitochondrial functions in metabolic syndrome
- … acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1α,(PGC-1α), peroxisome proliferator-activated …
- PGC-1α ameliorates AngiotensinII-induced eNOS dysfunction in human aortic endothelial cells
- PGC-1α plays a major role in the anti-apoptotic effect of 15-HETE in pulmonary artery endothelial cells
- Impact of liver PGC‐1α on exercise and exercise training‐induced regulation of hepatic autophagy and mitophagy in mice on HFF
- The effect of 8 weeks of high intensity interval training on the expression of PGC-1α and VEGF genes in myocardial muscle of male healthy rats
- A CRM1 inhibitor alleviates cardiac hypertrophy and increases the nuclear distribution of NT-PGC-1α in NRVMs
- Fucoidan suppresses mitochondrial dysfunction and cell death against 1-methyl-4-phenylpyridinum-induced neuronal cytotoxicity via regulation of PGC-1α expression
- Fat and bone: PGC-1α regulates mesenchymal cell fate during aging and osteoporosis
- HuoXue QianYang QuTan Recipe attenuates left ventricular hypertrophy in obese hypertensive rats by improving mitochondrial function through SIRT1/PGC-1α …
- PGC‐1α gene transfer improves muscle function in dystrophic muscle following prolonged disease progress
- Recruitment of RNA polymerase II to metabolic gene promoters is inhibited in the failing heart possibly through PGC-1α (Peroxisome Proliferator-Activated Receptor-γ …
- RIP140/PGC-1α axis involved in vitamin A-induced neural differentiation by increasing mitochondrial function
- The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of PGC-1α and Pink1
- Rs1894720 polymorphism in MIAT increased susceptibility to age‐related hearing loss by modulating the activation of miR‐29b/SIRT1/PGC‐1α signaling
- Human muscle precursor cells overexpressing PGC-1α enhance early skeletal muscle tissue formation
- The effects of interval training intensity on skeletal muscle PGC-1α in type2 diabetic male rats
- Salicylates promote mitochondrial biogenesis by regulating the expression of PGC-1α in murine 3T3-L1 pre-adipocytes
- Acute simulated soccer-specific training increases PGC-1α mRNA expression in human skeletal muscle
- Lack of age-related clinical progression in PGC-1α-deficient mice–implications for mitochondrial encephalopathies
- Inhibition of PGC-1α after chemotherapy-mediated insult confines multiple myeloma cell survival by affecting ROS accumulation
- Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast CancerShcA Signaling Controls Breast Tumor Metabolism
- Inhibitory effects of SRT1720 on the apoptosis of rabbit chondrocytes by activating SIRT1 via p53/bax and NF-κB/PGC-1α pathways
- Dexamethasone mediated downregulation of PGC-1α and visfatin regulates testosterone synthesis and antioxidant system in mouse testis
- mRNA PGC-1α levels in blood samples reliably correlates with its myocardial expression: study in patients undergoing cardiac surgery
- Muscle PGC‐1α in exercise and fasting‐induced regulation of hepatic UPR in mice
- Identification of PGC-1α activating constituents in Zingiberaceous crude drugs
- Peroxisome proliferator-activated receptor-γ–coactivator 1α (PGC-1α) gene expression in chronic kidney disease patients on hemodialysis: relation to hemodialysis …
- Histopathological comparison of Kearns-Sayre syndrome and PGC-1α-deficient mice suggests a novel concept for vacuole formation in mitochondrial encephalopathy
- Interleukin-6 affects aging-related changes of the pparα-PGC-1α axis in the myocardium
- Adiponectin partially rescues high glucose/high fat-induced impairment of mitochondrial biogenesis and function in a PGC-1α dependent manner.
- Concerted action of histone methyltransferases G9a and PRMT-1 regulates PGC-1α-RIG-I axis in IFNγ treated glioma cells
- Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic …
- Modulation of cardiac vascular endothelial growth factor and PGC-1α with regular postexercise cold-water immersion of rats
- Phosphorylation of 4EBP by oral leucine administration was suppressed in the skeletal muscle of PGC-1α knockout mice
- Non-motor Behavioral Alterations of PGC-1α-Deficient Mice–A Peculiar Phenotype With Slight Male Preponderance and No Apparent Progression
- Lack of PGC-1α exacerbates high glucose-induced apoptosis in human umbilical vein endothelial cells through activation of VADC1
- Bofutsushosan ameliorates obesity in mice through modulating PGC-1α expression in brown adipose tissues and inhibiting inflammation in white adipose tissues
- The influence of ethnicity in the association of WC, WHR, hypertension and PGC-1α (Gly482Ser), UCP2− 866 G/A and SIRT1− 1400 T/C polymorphisms with T2D in …
- … selenium intake from enriched milk casein impairs hepatic insulin sensitivity via attenuated IRS/PI3K/AKT signaling and decreased PGC-1α expression in male …
- Effect of eight weeks aerobic and combined training on serum levels of sirtuin 1 and PGC-1α in coronary artery bypass graft patients
- PGC‐1α in hepatic UPR during high‐fat high‐fructose diet and exercise training in mice
- The effect of aerobic exercise and caloric restriction on mice’s brain tissue PGC-1α levels and their memory abilities
- A20 deubiquitinase controls PGC-1α expression in the adipose tissue
- Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts
- Lifelong parental voluntary wheel running increases offspring hippocampal PGC-1α mRNA expression but not mitochondrial content or Bdnf expression
- GCN-5/PGC-1α signaling is activated and associated with metabolism in cyclin E1-driven ovarian cancer
- PGC-1α induced browning promotes involution and inhibits lactation in mammary glands
- Rosiglitazone, but not epigallocatechin-3-gallate, attenuates the decrease in PGC-1α protein levels in palmitate-induced insulin-resistant C2C12 cells
- The potential use of PGC-1α and PGC-1β to protect the retina by stimulating mitochondrial repair
- Exercise and PGC-1α in inflammation and chronic disease
- NGF promotes mitochondrial function by activating PGC‐1α in TM 4 Sertoli cells
- β1-and β2-adrenergic receptor stimulation differ in their effects on PGC-1α and atrogin-1/MAFbx gene expression in chick skeletal muscle
- … -1α (PGC-1α) regulates the expression of B-cell lymphoma/leukemia-2 (Bcl-2) and promotes the survival of mesenchymal stem cells (MSCs) via PGC-1α …
- PGC‐1α regulates the expression and activity of IRF‐1
- Mitochondrial biogenesis and PGC‐1α gene expression in male broilers from ascites‐susceptible and‐resistant lines
- … ‐thyroid hormone combined protocol as a novel approach to metabolic stress disorders: Relation to mitochondrial adaptation via liver PGC‐1α and sirtuin1 activation
- Opposing action of NCoR1 and PGC-1α in mitochondrial redox homeostasis
- A Novel Danshensu-tetramethylpyrazine conjugate DT-018 provides cardioprotection by preserving mitochondrial function through the MEF2D/PGC-1α pathway
- Constitutive PGC-1α Overexpression in Skeletal Muscle Does Not Improve Morphological Outcome in Mouse Models of Brain Irradiation or Cortical Stroke
- Cytotoxicity of Malondialdehyde and Cytoprotective Effects of Taurine via Oxidative Stress and PGC-1α Signal Pathway in C2C12 Cells
- Association of PGC-1α gene with type 2 diabetes in three unrelated endogamous groups of North-West India (Punjab): a case-control and meta-analysis study
- Improvement of the physical performance is associated with activation of NO/PGC-1α/mtTFA signaling pathway and increased protein expressions of electron …
- Comparisons of different myosin heavy chain types, AMPK, and PGC-1α gene expression in the longissimus dorsi muscles in Bama Xiang and Landrace pigs
- The transcriptional modulator Ifrd1 controls PGC‐1α expression under short‐term adrenergic stimulation in brown adipocytes
- Decreased PGC-1α post-cardiopulmonary bypass leads to impaired oxidative stress in diabetic patients
- Phytol promotes the formation of slow-twitch muscle fibers through PGC-1α/mirna but not mitochondria oxidation
- A key role of PGC‐1α transcriptional coactivator in production of VEGF by a novel angiogenic agent COA‐Cl in cultured human fibroblasts
- Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and maintain a lipid-based metabolism
- Low pre‐exercise muscle glycogen availability offsets the effect of post‐exercise cold water immersion in augmenting PGC‐1α gene expression
- Delayed puberty by ziram is associated with down regulation of testicular phosphorylated AKT1 and SIRT1/PGC-1α signaling
- Blood PGC-1α concentration predicts myocardial salvage and ventricular remodeling after ST-segment elevation acute myocardial infarction
- The effect of endurance training on gene expression of PGC-1α, BDNF and learning disorders in the hippocampus of aging rats
- Mineral-enriched deep-sea water modulates lactate metabolism via PGC-1α-mediated metabolic reprogramming
- Sustained elevation of NF-κB activity sensitizes offspring of maternal inflammation to hypertension via impairing PGC-1α recovery
- The effect of aerobic training with Citrus aurantium L. on SIRT1 and PGC-1α gene expression levels in the liver tissue of elderly rats
- Changes in the PGC-1α and mtDNA copy number may play a role in the development of pelvic organ prolapse in pre-menopausal patients
- Enhanced therapeutic potential of the secretome released from adipose-derived stem cells by PGC-1α-driven upregulation of mitochondrial proliferation
- Synergism between PGC-1α and estrogen in the survival of endometrial cancer cells via the mitochondrial pathway
- Hepatic MicroRNA Expression by PGC-1α and PGC-1β in the Mouse
- Small interfering RNA targeting PGC-1α inhibits VEGF expression and tube formation in human retinal vascular endothelial cells
- Yiqi Yangyin and Huatan Quyu granule can improve skeletal muscle energy metabolism in a type 2 diabetic rat model by promoting the AMPK/SIRT/PGC-1α …
- The Effect Of PGC-1α On Acute Lung Injury
- Inhibition of adhesion molecule gene expression and cell adhesion by the metabolic regulator PGC-1α
- Dose‐and time‐dependent alterations in lipid metabolism after pharmacological PGC‐1α activation in L6 myotubes
- The effect of eight weeks of water training on Sirt1, PGC-1α and body fat percentage in obese men
- PGC-1α concentration in skeletal muscle by exercise is controlled by PPARβ/δ through post-transcriptional mechanism: the effects of PPARβ/δ silence on PGC-1α …
- PGC-1α coordinates with Bcl-2 to control the cell cycle in U251 cells through reducing ROS
- Effects of 4 week endurance training on PGC-1α expression in adipose tissue, ANGPTL8 serum concentrations and beta cells function of STZ diabetic rats
- Orchestrating Metabolic Flexibility: PGC-1α and Clinical Heart Failure
- Transcriptional coactivator PGC-1α binding to newly synthesized RNA via CBP80: a nexus for co-and posttranscriptional gene regulation
- … gene enhances aerobic metabolism of themselves and mitochondrial respiration of mammal cells to bring about improving metabolic syndrome through the PGC‐1α …
- New wine into old wineskins: PGC‐1α and NF‐κB in obesity and acute pancreatitis
- Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma
- Gene and Protein Expression Profile of Selected Molecular Targets Mediating Electrophysiological Function in PGC-1α Deficient Murine Atria
- Control of secreted protein gene expression and the mammalian secretome by the metabolic regulator PGC-1α
- … for three days reduces whole body glucose uptake, impairs muscle mitochondrial function and initiates opposing effects on PGC-1α promoter methylation in …
- Easily performed interval exercise induces to increase in skeletal muscle PGC-1α gene expression
- A feed-forward circuit of endogenous PGC-1α and estrogen related receptor α regulates the neuronal electron transport chain
- THE EFFECT OF 8 WEEKS AEROBIC TRAINING ON CARDIAC PGC-1α AND PLASMA IRISIN IN STZ-INDUCED DIABETICS’RATS
- Erratum: PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
- Retraction Notice to: Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype
- Regulation of Hepatic Gluconeogenesis by NT‐PGC‐1α, the short isoform of PGC‐1α
- PPARβ/δOverexpression Increase PGC-1αProtein through the Decreased PGC-1α Ubiquitination in Mouse Skeletal Muscle.
- Examining the Impact of Different Exercise Protocols on PGC‐1α and FNDC5 mRNA Expression in Human Skeletal Muscle
- Correction to: Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α‘
- GW27-e0632 NR reduced myocardial ischemia-reperfusion injury by improving mitochondrial biogenesis and reducing excessive autophagy via Sirt3-PGC-1α/P53 …
- The effects of PDK4 inhibition on AMPK protein levels and PGC-1α gene expression following endurance training in skeletal muscle of Wistar rats
- Saponins from Rhizoma Panacis Majoris attenuate myocardial ischemia/reperfusion injury via the activation of the Sirt1/Foxo1/PGC-1α and Nrf2/antioxidant defense …
- Exploring the Regulation of PGC-1α-Investigating the Gly482Ser Polymorphism of PGC-1a and the PGC-1α4 Isoform
- dl-3n-butylphthalide reduces oxygen-glucose deprivation-induced endothelial cell damage by increasing PGC-1α
- Acute Exercise‐Induced Mitophagy is Mediated in Part by PGC‐1α
- The Effect of Four Weeks of High-intensity Interval Training on PGC-1α and VEGF Protein Contents in Skeletal Muscle of Active Men
- The cancer drug dasatinib increases PGC-1α in adipose tissue but has adverse effects on glucose tolerance in obese mice
- Effects of myostatin deficiency on PGC-1α and FNDC5 expression in three different murine muscle types
- The effect of high intensity interval training and moderate intensity continuous training on mitochondrial content and PGC-1α of subcutaneous adipose tissue in male …
- Investigating Methylated Arginine Residues in PGC‐1α
- Effects of cadmium chloride on mitochondrial function and PGC-1α expression in HK-2 cells
- The Role and Regulation of PGC-1α and PGC-1β in Skeletal Muscle Adaptation
- The Combination of Aerobic and Resistance Exercise Induces Weight Loss via the PGC-1α/Irisin/UCP-1 Pathway
- Astaxanthin Attenuates Hepatic Damages and Mitochondrial Dysfunction in Nonalcoholic Fatty Liver Disease by Regulating the FGF21/PGC-1α Pathway
- Effect of electroacupuncture on the expression of PGC-1α and UCP-1 in the brown adipose tissue of obese rats
- PGC-1α overexpression via local in vivo transfection in mouse skeletal muscle
- Overexpression of PGC‐1α Increases Peroxisomal Biogenesis and Mitochondrial Lipid Oxidation in Human Primary Myotubes
- … Houtt, and Gardenia jasminoides Ellis fruit attenuates the exacerbation of energy, lipid, and glucose by increasing hepatic PGC-1α expression in estrogen …
- PGC-1α is associated with Schizothorax prenanti myoblast differentiation
- PGC-1α overexpression promotes mitochondrial biogenesis to protect auditory cells against cisplatin-induced cytotoxicity
- Erratum: PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
- The comparison of the influence of 12-week high-intensity interval training and continuous moderate intensity training on PGC-1α and Tfam mitochondrial proteins …
- Effects of aerobic exercise on PGC-1α, AMPK and SOD expression of skeletal muscle in 2type diabetic rats
- Arginine induces skeletal muscle fiber type conversion by upregulating Akirin2 and AMPK/PGC-1α in mice
- PGC-1α-Derived Peptide Influences Energy in Normal Human Dermal Fibroblasts
- Effect of Salicornia herbacea L. supplementation on tissue triglyceride concentrations and PGC-1α & PPAR-γ expression of skeletal muscle of rats fed a high-fat diet
- Measuring PGC-1α and Its Acetylation Status in Mouse Primary Myotubes
- Nuclear factor‐erythroid 2‐related factor‐2 (Nrf2) and peroxisome proliferator‐activated receptor γ coactivator‐1α (PGC‐1α) regulates proteolysis in cornea
- An Optimized Immunoblotting Protocol for Accurate Detection of Endogenous PGC-1α Isoforms in Various Rodent Tissues
- Endurance exercise increases the protein levels of PGC-1α and respiratory chain complexes in mouse skeletal muscle during atorvastatin administration
- Over-expression of PGC-1α reverses mitochondrial function reduction and apoptosis in OGD/R-induced neurons
- Erratum. Pathophysiological Mechanism of Bone Loss in Type 2 Diabetes Involves Inverse Regulation of Osteoblast Function by PGC-1α and Skeletal Muscle …
- Effect of eight weeks high intensity interval training on gene expression of PGC-1α, in male healthy rats fast-slow twitch muscles
- Cloning of PGC-1α from Grass Carp and Its Response to Cadmium-Induced Stress
- … of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by N terminus peroxisome proliferator-associated receptor gamma coactivator (NT-PGC)-1α.
- Erratum to: The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair
- A comparison of PGC-1α mRNA and protein expression in response to 1-week endurance training on alternate days or 4 consecutive days
- Effects of PGC‐1α Overexpression on Glucocorticoid‐induced Atrophy Signaling in C2C12 Muscle Cells
- The effect of aerobic exercise with and without blood flow restriction on lactate, cortisol and PGC-1α response in human skeletal muscle
- The Effect of Short Endurance Training on PGC-1α/FNDC5/BDNF Signalling Pathway In 6-OHDA-Induced Parkinson’s Rats
- PGC-1α Mediated Peripheral Nerve Protection of Tongxinluo in STZ-Induced Diabetic Rats
- Differential expression profile of PGC-1α gene in two phenotypically distinct muscles between two chicken (Gallus gallus) breeds.
- S-540 PGC-1α Protects Against Notch1-Induced Kidney Injury
- Ibrutinib in combination with venetoclax decreases mitochondrial bioenergetics through the Impaired BTK, AKT and AMPK/SIRT/PGC-1α signaling pathway in …
- Neuropathological characterization of FL-PGC-1α-deficient mice–implications for mitochondrial encephalopathy
- A comparison of the effect of eight weeks of high intensity interval training on PGC-1α gene expression levels in the slow twitch (ST) and fast twitch (FT) muscles …
- The role of NADPH oxidase 2 in regulating IL-15 and PGC-1α gene expressions following a period of high intensity interval training
- Effect of Electroacupuncture at Tinggong and Yifeng on D-galactose-induced Aging of Auditory Cortex through SIRT1/PGC-1α Pathway in Guinea Pigs
- The role of mitochondrial metabolism and PGC-1α on breast cancer bioenergetics and metastasis
- Effects of six-week high-intensity interval training (HIIT) on PGC-1α methylation in gastrocnemius muscle of obese rats
- PGC-1α is a critical activator of HO-1 that protects against cardiomyopathy in diabetic mice through recruitment of mitochondrial fusion proteins and function
- The role of NADPH oxidase 2 in regulating IL-15 and PGC-1α gene expressions following a period of high intensity interval training.
- Isorhamnetin activates Sirt1/PGC-1α signaling pathway to inhibit MPP+-induced SH-SY5Y cell injury
- OR-005 Effects of HIITand MICT for 10 weeks on myocardial AMPK and PGC-1α in rats: There is no full paper associated with this abstract
- NRF‐2 and PGC‐1α signaling regulate epithelial‐mesenchymal transition in mouse model
- Acute influence of mild hyperbaric oxygen at 1.25 atmospheres absolute with normal air on mitochondrial enzymes and PGC-1α mRNA levels in rat skeletal …
- Retracted: Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent …
- Advances in relationship between PGC-1α and tumor metabolism
- Correction: Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
- The effect of 3 weeks ergometer cycling training with and without vascular occlusion on Plasma concentration of Irisin and PGC-1α in healthy men
- Astragaloside IV attenuates pressure overload-induced cardiac hypertrophy by regulating PGC-1α signaling mediated energy biosynthesis
- PGC‐1α, a Novel Substrate for Protein Arginine Methyltransferase 7?
- PGC-1α in neurodegeneration and ageing
- Expression patterns of PPARγ2, PGC-1α, and MEF2C and their association with intramuscular fat content and skeletal muscle tenderness of crossbred Simmental …
- The effect of 14 weeks aerobic exercise on resveratrol supplementation on protein UCP-1, SIRT1, PGC-1α in liver tissue, subcutaneous and visceral fat tissue in male …
- Comparison of the Effects of Endurance Training on Alternate Days and on Consecutive 4 Days Each Week for 8 Weeks on the Abundance of PGC-1α, CaMKII, NRF-1 …
- GW26-e4506 Losartan cannot weaken the change of PGC-1α/NT-PGC-1α altered by Metformin in myocardial cells
- NRF-2/PGC-1α deficiency induces retinal degeneration in mice
- Correlation between PGC-1α gene polymorphism and metabolic diseases
- Local skeletal muscle heating and cooling impacts PGC-1β, but not PGC-1α expression after resistance exercise
- The Correlation Between Tfeb and PGC‐1α in Skeletal Muscle
- Relationship between hepatitis C virus and the transcription coactivator PGC-1α–A review
- Oxidative Phosphorylation Regulated By PGC-1α Promotes Multiple Myeloma Progression
- Generation of GABAergic interneuron-specific PGC-1α knockout mice
- CRTC2 Contributes to PGC‐1α Expression in Skeletal Muscle Cells
- The activation of PGC-1α protects the liver from IR damage
- Effect of hibiscus sabdariffa linn methanolic extract on heart hypertrophy index and PGC-1α in overtrained rat
- PL-020 Establishment of skeletal muscle-specific PGC-1α overexpression model via in vivo local transfection: There is no full paper associated with this abstract
- The effect of endurance training in air pollution on the expression of brain cortex PGC-1α and Atf2 genes in Wistar male rats
- Neuroprotective effects of PGC-1α activators in dopaminergic neurons
- PGC-1α is required to maintain RPE metabolism, integrity and function.
- PO-015 Meta-analysis on the relationship between PGC-1α-482 genetic polymorphism and exercise intervention in insulin resistance: There is no full text article …
- Control of human RPE differentiation and metabolism by PGC-1α: implications for AMD
- The expression of PGC-1α in carotid atherosclerotic plaque induced by cytomegalovirus
- PGC-1α Promoter Histone Acetylation is Life Saving in Fibrotic Hepatectomy
- Transcriptional Activation of PGC‐1α in Skeletal Muscle: Influence of Aging and Exercise
- Effect of exogenous PGC-1α on VEGF expression in human retinal vascular endothelial cells
- Pharmaceutical induction of PGC-1α protects retinal pigment epithelium from oxidative stress
- Relationship Between The Expression of PGC-1α and Muscle Fatigue In ApcMin/+ Mice.
- Associations of PPARG and PGC-1α gene polymorphisms with body structure
- The Aging Muscle Milieu and Transcription of PGC‐1α: a Role for Contractile Activity?
- Oscillatory Gene Promoter Regulation by PGC-1α and Sirt1 in Cardiac Energy Metabolism
- PGC-1α is important for maintaining the balance of muscle mass and myofiber types in unloaded muscle atrophy
- Sirt1 Maintains PGC-1α Function Through Periodic Promoter Release
- Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts
- Effect of PGC-1α knockdown on zebrafish cells under cold stress.
- Regulating Transcriptional Co-Activator PGC-1α for the Treatment of Sickle Cell Disease
- Regulation of retinal neovascularization in mice treated by recombinant PGC-1α protein
- PGC‐1α‐mediated Changes in Phospholipid Profiles of Exercise‐trained Skeletal Muscle
- Transcriptional regulation of kidney and skeletal muscle metabolism by the coactivator PGC-1α
- Total or endothelium specific PGC-1α deficiency is associated with alterations in vascular function in mice
- PGC-1α Determines the Formation of Neuronal Respiratory Chain Supercomplexes That Regulate Mitochondrial Function
- Expression of cytoglobin and PGC-1α is high during tail tissue regeneration of the house gecko (Hemidactylus platyurus)
- The Effect of Aerobic Exercise on PGC-1α and FNDC5 Gene Expression in Diabetic Male Rats
- Polymorphisms analysis of PGC-1α in 646 Locus of Guangxi Nandan-Yao chicken.
- Acute Expression of PGC‐1α Isoforms in Skeletal Muscle of Postmenopausal Women following Resistance Exercise
- AMP Deaminase 3 overexpression regulates cellular energetics and signaling for PGC-1α activation.
- The Effect of Endurance Training in Air Pollution on the Expression of Muscle Tissue Mitochondria PGC-1α and MEF2C Genes in Wistar Male Rats
- Nrf2‐ and PGC‐1α‐deficient mice: A novel animal model for impaired autophagy in AMD?
- AMP Deaminase 3 Overexpression Reduces Mitochondrial Content in C2C12 Myotubes by Decreasing PGC‐1α Promotor Activation
- Effect of Vitamin E on the Expression of SIRT1 and PGC-1α in Mice with Nonalcoholic Fatty Liver Disease
- Neuronal control of energy balance and modulation of muscle aging by the transcriptional coactivator PGC-1α
- Stimulation of PGC-1α to attenuate Duchenne muscular dystrophy disease pathology and activate autophagy
- Analysis of tissue specific regulatory targets of co-factor PGC-1α using bioinformatics methods
- Gluconeogenesis, lipogenesis, and HBV replication are commonly regulated by PGC-1α-dependent pathway
- The Molecular Basis of Increased Diabetes Susceptibility in Carriers of the PGC-1α (482Ser) Risk Allele
- The alterations of PGC-1α expression and epigenetic modifications in the retina of streptozotocin-induced diabetic rats
- PGC‐1α–Dependent TFEB Expression and Activation with Exercise
- Anti-inflammatory action of β-hydroxybutyrate via modulation of PGC-1α and FoxO1, mimicking calorie restriction
- The Effect of High-Intensity Interval Training in Obese Female Rats before Pregnancy on Fatigue Time, Methylation of PGC-1α and Sarcolipin Genes in the …
- Mitochondrial Regulation Downstream of the Transcriptional Coactivator PGC-1α Is Required for NK Cell Function During an Immune Response
- Role of Inflammation on Metabolic Transcription Factors: PPARγ and PGC-1α
- Loss of PGC-1α function in RPE induces EMT and promotes retinal degeneration
- Decreased PGC‐1α‐SIRT1 Signaling Leads to Impaired Angiogenesis in Persistent Pulmonary Hypertension of the Newborn (PPHN)
- THE DEFICIENCY OF THE TRANSCRIPTIONAL COACTIVATOR PGC-1α INCREASES RENAL INJURY IN ACUTE KIDNEY INJURY (AKI)
- Role of SIRT1 in renal ischemia-reperfusion injury and its effect on NF-κBp65-PGC-1α signal pathway in mice
- The Effect of Consumption of Quercetin Supplement on Gene Expression of PGC-1α during Sedentary Period in Active Rats after a HIIT Course
- PGC‐1α Upregulates Mitochondrial Sirtuins and Reduces Protein Acetylation in Skeletal Muscle of Old Mice.
- PGC-1α regulates mitochondrial calcium homeostasis, SR stress and cell death to mitigate skeletal muscle aging
- GW27-e1023 Atorvastain Attenuates TNF-α-induced Increase of Glucose Oxidation Through PGC-1α Upregulation in cardiomyocytes
- SAT-120 RESTORATION OF PGC-1α ACTIVITY BY DELETION OF SMAD3 PROTECTS AGAINST KIDNEY INJURY IN CRP TG MICE WITH UNILATERAL URETERAL …
- PO-014 The effects of HIIT on ROS-AMPK-PGC-1α pathway in skeletal muscle and VO2max of ageing Wistar rats.: There is no full text article associated with this …
- Role of mitochondria in diabetic peripheral Influencing neuropathy: the NAD+-dependent SIRT1–PGC-1α–TFAM pathway
- PGC-1α Mediates Differentiation Arrest of Murine Bone Marrow-derived Endothelial Progenitor Cells in Diabetes
- Physiological cardiac hypertrophy activates PPARγ/PGC‐1α axis and up‐regulates perilipin family
- … PGC-1α, Restores Mitochondrial Function, LV Function, and Ameliorates Development of Cardiovascular Disease in Db Mice That is Reversed by Lentiviral-PGC-1α …
- Investigating the effects of rosiglitazone and epigallocatechin-3-gallate on PGC-1α protein expression in palmitate-induced insulin resistant C2C12 skeletal muscle …
- Calcium deficiency affects serum glucose and lipids by inhibiting PGC-1α expression in skeletal muscle of rats
- PGC-1α regulates mitochondrial-sarcoplasmic reticulum (SR)-mediated calcium exchange, SR stress and cell death to mitigate skeletal muscle aging
- Abstract P233: Diabetic Cardiomyopathy is Reversed by Increased Mitochondrial Bioenergetics Due to PGC-1α Activation by EET Treatment of Obese Mice
- PGC‐1α Activation Confers Plasticity in the Mediator of Dilation in Healthy and Diseased Human Arterioles
- Low-intensity exercise in the acute phase of lipopolysaccharide-induced sepsisimproves lipid metabolism and survival in mice by stimulating PGC-1α …
- … Therapy Improves Age-related Collateral Development With Ischemia Through p53 and Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α)
- Effect Of Eight Weeks Of High Intensity Interval Training On Ampk And PGC-1α Gene Expression Levels In The Soleus Muscles In Rats With Myocardial Infarction
- GW27-e0440 Increased nuclear NT-PGC-1α via inhibition of CRM1 can enhance fatty acid oxidation in NRCM
- Impact of β-adrenergic signaling in PGC-1α-mediated adaptations in mouse skeletal muscle 2
- The Effect of Different Weeks of High Intensity Interval Training and Moderate-intensity Aerobic Exercise on Skeletal Muscle’s AMPK and PGC-1α of Rats
- Passive and post-exercise cold-water immersion augments PGC-1α and VEGF expression in human skeletal muscle.
- Regulation of endothelial function and angiogenesis by PGC-1α relies on ROS control of vascular stability
- Peroxisome Proliferator‐Activated γ Coactivator‐1α (PGC‐1α) mRNA Expression Correlates Highly with mRNA Expression of Myosin Heavy Chain (MHC) Isoforms in …
- OR-003 Time-sequential Changes of Myocardial AMPK and PGC-1α Expression during Detraining between High-intensity Interval Training and Moderate-intensity …
- Long‐term Quercetin Treatment is Unable to Sustain Elevated PGC‐1α Pathway Activity in the mdx Diaphragm
- Lactate administration increases mRNA expression of PGC-1α and UCP3 in mouse skeletal muscle
- PGC-1α-mediated Muscle/brain Crosstalk and Antidepressant Effects of Exercise—Reflaction and Prospect from Integrative Biology
- THE EFFECTS OF A HIGH-FAT DIET AND EXERCISE ON THE PGC-1α-FNDC5/IRISIN PATHWAY IN C57BL/6 MICE
- Enhancing PGC-1α Activity Improves Heart Function Through Activating Mitochondrial Biogenesis in Chagas Disease
- The Protumor Role of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha (PGC-1α) In Neuroblastoma
- Regulation of SIRT1, sirt3, PGC-1α, and LRP130 in response to energetic stress in human skeletal muscle
- Does The Polymorphism Of PGC-1α Influence The Pwv Of The Long-Lived Person Born In The 1940S Who Experienced A Rough Meal In Early Childhood?
- Transcription Dysregulation of the PGC-1α Pathway in Huntington’s Disease Pathogenesis: From Metabolic Derangement to Neurodegeneration
- Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes …
- Effects of phlegm-resolving and stasis-removing herbal drugs on PGC-1α mRNA expressions and insulin resistance in NAFLD rats
- Mechanistic Control of the Cold-Induced Augmentation of the Transcriptional Co-Activator PGC-1α
- The Impact of PGC-1α on Engineered Muscle Tissue and the Use of PET-Scan for Cell Tracking and Functional Analyses
- Clear cytoplasm of renal cell carcinoma is more than a morphologic phenotype: relation to drug sensitivity, AMPK/PGC-1α pathway, and mitochondria
- Corrigendum: PGC-1α silencing compounds the perturbation of mitochondrial function caused by mutant SOD1 in skeletal muscle of ALS mouse model
- Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential
- The knockout of aldose reductase accelerates liver regeneration through AMPK/SIRT1/PGC-1α network
- Nrf2‐ and PGC‐1α‐deficient mice: A novel animal model for disturbed proteostasis and RPE degeneration
- The Nrf2 and PGC-1α deficient murine retina reveals retinal pigment epithelium damage that coincides with autophagy decline and damaged mitochondria.
- Effect of Resveratrol Supplementation and Aerobic Exercise on the Protein SIRT1 and PGC-1α Skeletal Muscle and Subcutaneous Fat Tissue’s UCP-1 Levels in …
- Abstract P608: Obesity Induced Hypertension Exacerbated Through Upregulation Of Renal Naci Cotransporter, Reversed By Increasing PGC-1α-ho-1 Gene …
- Exercise and Regulation of Metabolic Function in Human Skeletal Muscle: with Special Reference to PGC-1α and the Mitochondria
- The Effect of 8 Weeks of Aerobic Exercise on the Expression of PGC-1α and VEGF Genes in Healthy Male Rats’ Myocardial Muscle
- Nuclear factor-erythroid 2-related factor-2 (Nrf2) and peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) deficient mice: Dissecting the …
- … Altered long non-coding RNA expression profile in rabbit atria with atrial fibrillation: TCONS_00016478 modulates atrial energy metabolic remodeling through PGC-1α …
- PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity.(Erratum) Aging, 2015; 7 (9): 629‐647.
- Protective effects of crocin on myocardial ischemia and hypoxia induced by ischemia and hypoxia through C/EBP-β/PGC-1α/UCP3 in rats
- Overexpression of PGC-1α Increases Peroxisomal Activity and Mitochondrial Fatty Acid Oxidation in Human Primary Myotubes 2
- Empagliflozin Directly Stimulates PGC-1α-Dependent Mitochondrial Biogenesis in Cardiac Cells; A Potential Mechanism Associated With Its Cardiovascular Benefits
- Restoration of PGC-1α activity by deletion of Smad3 protects against kidney injury in CRP TG mice with unilateral ureteral obstruction (UUO)
- Gain-of-function mutant p53 enhances mitochondrial ROS through the inhibition of PGC-1α/UCP2 axis in cancer cells
- GW26-e4408 The protective effects of salidroside from exhaustive exercise-induced heart injury by enhancing the PGC-1α–NRF1–NRF2 pathway and mitochondrial …
- Abstract B27: RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis
- Post-exercise cold-water immersion modulates skeletal muscle PGC-1α mRNA expression in immersed and non-immersed limbs: evidence of 2 systemic regulation 3
- A Key Role of PGC-1α Co-transcription Factor, but not HIF1α Transcription Factor, in Production of Vascular Endothelial Growth Factor (VEGF) by a Novel Angiogenic …
- A single bout of whole-leg, peristaltic pulse external pneumatic compression upregulates PGC-1α mRNA and eNOS protein in human skeletal muscle tissue
- Activation of cAMP/CREB/PGC-1α Pathway Plays a Key Role for a Novel Adenosine-like Angiogenic Agent COA-Cl to Induce Production of Vascular Endothelial …
- Signalling Through the PGC-1α Pathway Mediates an Inducible Stress Response in Retinal Astrocytes to Resist Oxidative and Metabolic Insults
- Obesity, Diabetes and Energy Homeostasis: Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and …
- Transcriptional control, but not sub-cellular location, of PGC-1α is altered following 1 exercise in a hot environment 2 3 Heesch, Matthew W1, Shute, Robert J2 …
- … OF PHYSICAL PERFORMANCE IN 5/6 NEPHRECTOMIZED CKD MODEL MICE THROUGH EPIGENETIC MODULATION OF PGC-1α EXPRESSION BY A GASTRIC …
- Epigenetic modifications of the PGC-1α promoter in Limb Girdle Muscular Dystrophy 2D account for impaired mitochondrial biogenesis: new perspective in HDAC …
- Mitochondrial metabolism is inhibited by the HIF 1α‐MYC‐PGC‐1β axis in BRAF V600E thyroid cancer
- PGC-1α, inflammation, and oxidative stress: an integrative view in metabolism
- PGC-1α-mediated regulation of mitochondrial function and physiological implications
- Natural products, PGC-1α, and Duchenne muscular dystrophy
- SnapShot: Regulation and biology of PGC-1α
- The role of PGC-1α and mitochondrial biogenesis in kidney diseases
- Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation
- Multiple levels of PGC-1α dysregulation in heart failure
- Upregulation of neuronal PGC-1α ameliorates cognitive impairment induced by chronic cerebral hypoperfusion
- PGC-1α in disease: recent renal insights into a versatile metabolic regulator
- Covering the Role of PGC-1α in the Nervous System
- A new perspective on ameliorating depression-like behaviors: suppressing neuroinflammation by upregulating PGC-1α
- LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling
- Metabolic cross-talk between skeletal muscle and adipose tissue in high-intensity interval training vs. moderate-intensity continuous training by regulation of PGC-1α
- Hexavalent chromium induces mitochondrial dynamics disorder in rat liver by inhibiting AMPK/PGC-1α signaling pathway
- Effect of High-intensity Interval Training and Accumulated Exercise on PGC-1α and SIRT3 Levels in the Skeletal Muscle of Rats and Bioinformatics Analysis
- … 1 receptor attenuates early brain injury following subarachnoid hemorrhage by controlling mitochondrial metabolism via AMPK/SIRT1/PGC-1α pathway in rats
- Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity
- Mitophagy receptor FUNDC1 is regulated by PGC‐1α/NRF1 to fine tune mitochondrial homeostasis
- PGC-1α-targeted therapeutic approaches to enhance muscle recovery in aging
- PGC-1α affects skeletal muscle and adipose tissue development by regulating mitochondrial biogenesis
- Dysregulation of PGC-1α-dependent transcriptional programs in neurological and developmental disorders: therapeutic challenges and opportunities
- Regulation of PGC-1α expression by a GSK-3β-TFEB signaling axis in skeletal muscle
- Berberine protects against diabetic kidney disease via promoting PGC‐1α‐regulated mitochondrial energy homeostasis
- … Cognitive Impairment in an APP/PS1 transgenic mouse model of Alzheimer’s disease by relieving oxidative stress through activating the SIRT1/PGC-1α …
- Role of PGC-1α in the Mitochondrial NAD+ Pool in Metabolic Diseases
- Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle
- Korean Red Ginseng Improves Astrocytic Mitochondrial Function by Upregulating HO-1-Mediated AMPKα–PGC-1α–ERRα Circuit after Traumatic Brain Injury
- Contribution of PGC-1α to obesity-and caloric restriction-related physiological changes in white adipose tissue
- Activation of PGC-1α and mitochondrial biogenesis protects against prenatal hypoxic–ischemic brain injury
- … promotes cell survival and mitochondrial quality of bone marrow mesenchymal stem cells, and accelerates cutaneous wound healing via PGC-1α/SIRT3/HIF-1α …
- PI3K/AKT phosphorylation activates ERRα by upregulating PGC-1α and PGC‑1β in gallbladder cancer
- SIRT1 protects dopaminergic neurons in parkinson’s disease models via PGC-1α-mediated mitochondrial biogenesis
- The m6A methyltransferase METTL3 modifies PGC-1α mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes
- Activation of GPR39 with TC-G 1008 attenuates neuroinflammation via SIRT1/PGC-1α/Nrf2 pathway post-neonatal hypoxic–ischemic injury in rats
- Resveratrol regulates muscle fiber type conversion via miR-22-3p and AMPK/SIRT1/PGC-1α pathway
- Imbalance in mitochondrial dynamics induced by low PGC-1α expression contributes to hepatocyte EMT and liver fibrosis
- … lipopolysaccharide-induced liver injury through inhibiting caspase-11-mediated hepatocyte pyroptosis via PGC-1α-dependent acyloxyacyl hydrolase …
- The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-PGC-1α signalling pathway
- Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-κB-NLRP3-GSDMD and AMPK-PGC-1α axes
- PGC-1α activator ZLN005 promotes maturation of cardiomyocytes derived from human embryonic stem cells
- Resveratrol improves mitochondrial biogenesis function and activates PGC-1α pathway in a preclinical model of early brain injury following subarachnoid …
- PGC‐1α regulates myonuclear accretion after moderate endurance training
- MOTS-c interacts synergistically with exercise intervention to regulate PGC-1α expression, attenuate insulin resistance and enhance glucose metabolism in …
- Galangin Reverses H2O2-Induced Dermal Fibroblast Senescence via SIRT1-PGC-1α/Nrf2 Signaling
- Hengshun Aromatic Vinegar Improves Glycolipid Metabolism in Type 2 Diabetes Mellitus via Regulating PGC-1α/PGC-1β Pathway
- Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway
- Rhein Relieves Oxidative Stress in an Aβ1-42 Oligomer-Burdened Neuron Model by Activating the SIRT1/PGC-1α-Regulated Mitochondrial Biogenesis
- Neohesperidin enhances PGC-1α-mediated mitochondrial biogenesis and alleviates hepatic steatosis in high fat diet fed mice
- … sensitivity and mitochondrial respiration in skeletal muscle of type-2 diabetic mice through insulin signaling pathway and AMPK/SIRT1/PGC-1α/PPAR-γ activation
- PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections
- Atractylenolide III improves mitochondrial function and protects against ulcerative colitis by activating AMPK/SIRT1/PGC-1α
- Effect of endurance training and PGC-1α overexpression on calculated lactate production volume during exercise based on blood lactate concentration
- Pharmacologic induction of PGC‐1α stimulates fetal haemoglobin gene expression
- Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis
- The effects of different training modalities on monocarboxylate transporters MCT1 and MCT4, hypoxia inducible factor-1α (HIF-1α), and PGC-1α gene expression in rat …
- Looking beyond PGC-1α: emerging regulators of exercise-induced skeletal muscle mitochondrial biogenesis and their activation by dietary compounds
- Mitochondrial transfer from mesenchymal stem cells to macrophages restricts inflammation and alleviates kidney injury in diabetic nephropathy mice via PGC-1α …
- The role of PGC-1α-mediated mitochondrial biogenesis in neurons
- Dihydromyricetin improves mitochondrial outcomes in the liver of alcohol-fed mice via the AMPK/Sirt-1/PGC-1α signaling axis
- Irisin acts via the PGC-1α and BDNF pathway to improve depression-like behavior
- Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway
- Lactate promotes metastasis of normoxic colorectal cancer stem cells through PGC-1α-mediated oxidative phosphorylation
- Exercise- and Cold-Induced Human PGC-1α mRNA Isoform Specific Responses
- Omega-3 fatty acids upregulate SIRT1/3, activate PGC-1α via deacetylation, and induce Nrf1 production in 5/6 nephrectomy rat model
- … neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α …
- Hippocampal PGC-1α-mediated positive effects on parvalbumin interneurons are required for the antidepressant effects of running exercise
- PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments
- Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway
- Quercetin Attenuates Diabetic Peripheral Neuropathy by Correcting Mitochondrial Abnormality via Activation of AMPK/PGC-1α Pathway in vivo and in vitro
- Estrogen-related receptor alpha (ERRα) is required for PGC-1α-dependent gene expression in the mouse brain
- Transcriptome-wide analysis of PGC-1α–binding RNAs identifies genes linked to glucagon metabolic action
- Roflupram exerts neuroprotection via activation of CREB/PGC‐1α signalling in experimental models of Parkinson’s disease
- Oroxylin a promotes PGC-1α/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease
- Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC-1α-mediated mitochondrial biogenesis and suppression of neuroinflammation
- SIRT1/PGC-1α/PPAR-γ correlate with hypoxia-induced chemoresistance in non-small cell lung cancer
- … inhibits diabetes-induced atrial mitochondrial oxidative stress and improves mitochondrial biogenesis, dynamics, and function through the PPAR-γ/PGC-1α …
- PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis
- SIRT3-mediated SOD2 and PGC-1α contribute to chemoresistance in colorectal cancer cells
- Suppression of PGC-1α drives metabolic dysfunction in tgfβ2-induced emt of retinal pigment epithelial cells
- Acacetin ameliorates cardiac hypertrophy by activating Sirt1/AMPK/PGC-1α pathway
- Cardiac hypertrophy drives PGC-1α suppression associated with enhanced O-glycosylation
- PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII
- LncRNA HOXA-AS2 regulates microglial polarization via recruitment of PRC2 and epigenetic modification of PGC-1α expression
- Effect of DEHP and DnOP on mitochondrial damage and related pathways of Nrf2 and SIRT1/PGC-1α in HepG2 cells
- Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice
- Deciphering the role of PGC-1α in neurological disorders: from mitochondrial dysfunction to synaptic failure
- N1‑methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC-1α signaling pathway
- NF-κB p65 Attenuates Cardiomyocyte PGC-1α Expression in Hypoxia
- Glycometabolic reprogramming-mediated proangiogenic phenotype enhancement of cancer-associated fibroblasts in oral squamous cell carcinoma: role of PGC-1α …
- … HETE synthesis inhibition attenuates traumatic brain injury–induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC‐1α pathway: A translational …
- Changes in PGC‐1α/SIRT1 signaling impact on mitochondrial homeostasis in amyloid-beta peptide toxicity model
- CTRP3 activates the AMPK/SIRT1-PGC-1α pathway to protect mitochondrial biogenesis and functions in cerebral ischemic stroke
- Liraglutide Regulates Mitochondrial Quality Control System through PGC-1α in a Mouse Model of Parkinson’s Disease
- Novel PGC-1α/ATF5 Axis Partly Activates UPRmt and Mediates Cardioprotective Role of Tetrahydrocurcumin in Pathological Cardiac Hypertrophy
- PGC-1α alleviates mitochondrial dysfunction via TFEB-mediated autophagy in cisplatin-induced acute kidney injury
- Tannic acid provides neuroprotective effects against traumatic brain injury through the PGC-1α/Nrf2/HO-1 pathway
- Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model
- Flavonoids modulate AMPK/PGC-1α and interconnected pathways toward potential neuroprotective activities
- PGC-1α protects against hepatic ischemia reperfusion injury by Activating PPARα and PPARγ and regulating ROS production
- Comprehensive amelioration of high-fat diet-induced metabolic dysfunctions through activation of the PGC-1α pathway by probiotics treatment in mice
- Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non‐alcoholic fatty liver disease by up‐regulating the FGF21/PGC‐1α pathway
- Impairment of PGC-1α-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer’s pathology in the 3xTg mouse model of Alzheimer’s …
- Ferruginol restores SIRT1-PGC-1α-mediated mitochondrial biogenesis and fatty acid oxidation for the treatment of dox-induced cardiotoxicity
- Hyperbaric oxygen therapy improves Parkinson’s disease by promoting mitochondrial biogenesis via the SIRT-1/PGC-1α pathway
- LncRNA GAS5 inhibits miR-579-3p to activate SIRT1/PGC-1α/Nrf2 signaling pathway to reduce cell pyroptosis in sepsis-associated renal injury
- Zearalenone promotes follicle development through activating the SIRT1/PGC-1α signaling pathway in the ovaries of weaned gilts
- Urolithin a protects dopaminergic neurons in experimental models of Parkinson’s disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling …
- … insulin resistance in mice by regulating the expression of the mitochondrial-derived peptide MOTS-c and its response to exercise via APPL1–SIRT1–PGC-1α
- PGC‐1α protects from myocardial ischaemia‐reperfusion injury by regulating mitonuclear communication
- Dihydromyricetin Protects Against Gentamicin-Induced Ototoxicity via PGC-1α/SIRT3 Signaling in vitro
- Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling
- DMEP induces mitochondrial damage regulated by inhibiting Nrf2 and SIRT1/PGC-1α signaling pathways in HepG2 cells
- PGC-1α induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma
- LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway
- Impacts of altered exercise volume, intensity, and duration on the activation of AMPK and CaMKII and increases in PGC-1α mRNA
- Arginine Methylation of the PGC-1α C-Terminus Is Temperature-Dependent
- Ecklonia cava extracts decrease hypertension-related vascular calcification by modulating PGC-1α and SOD2
- MiR-22 inhibition alleviates cardiac dysfunction in doxorubicin-induced cardiomyopathy by targeting the sirt1/PGC-1α pathway
- PGC-1α reduces Amyloid-β deposition in Alzheimer’s disease: Effect of increased VDR expression
- PGC-1α participates in tumor chemoresistance by regulating glucose metabolism and mitochondrial function
- Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1α signaling
- Upregulation of PGC-1α attenuates oxygen-glucose deprivation-induced hippocampal neuronal injury
- Overexpression of PGC-1α influences the mitochondrial unfolded protein response (mtUPR) induced by MPP+ in human SH-SY5Y neuroblastoma cells
- Lactobacillus rhamnosus GG Colonization in Early Life Ameliorates Inflammaging of Offspring by Activating SIRT1/AMPK/PGC-1α Pathway
- Activation of PGC‐1α‐dependent mitochondrial biogenesis supports therapeutic effects of silibinin against type I diabetic periodontitis
- Stemness of Normal and Cancer Cells: The Influence of Methionine Needs and SIRT1/PGC-1α/PPAR-α Players
- Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3
- Emerging Protective Actions of PGC-1α in Diabetic Nephropathy
- Hypermethylation of the gene coding for PGC-1α in peripheral blood leukocytes of patients with Parkinson’s disease
- Exercise training-induced PPARβ increases PGC-1α protein stability and improves insulin-induced glucose uptake in rodent muscles
- Salvianolic acid B protects against sepsis‑induced liver injury via activation of SIRT1/PGC-1α signaling
- A role for PGC-1α in transcription and excitability of neocortical and hippocampal excitatory neurons
- Lifelong aerobic exercise alleviates sarcopenia by activating autophagy and inhibiting protein degradation via the AMPK/PGC-1α signaling pathway
- PARP-1 and SIRT-1 are interacted in diabetic nephropathy by activating AMPK/PGC-1α signaling pathway
- PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action
- … response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway
- Eight weeks of high-intensity interval static strength training improves skeletal muscle atrophy and motor function in aged rats via the PGC-1α/FNDC5/UCP1 pathway
- PGC-1α regulates autophagy to promote fibroblast activation and tissue fibrosis
- Urolithin a alleviates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells through SIRT1/PGC-1α pathway
- Activation of LRP6 with HLY78 attenuates oxidative stress and neuronal apoptosis via GSK3β/Sirt1/PGC-1α pathway after ICH
- Codonopsis lanceolata and its active component Tangshenoside I ameliorate skeletal muscle atrophy via regulating the PI3K/Akt and SIRT1/PGC-1α pathways
- Telomeric injury by KML001 in human T cells induces mitochondrial dysfunction through the p53-PGC-1α pathway
- SIRT1/PGC-1α signaling activation by mangiferin attenuates cerebral hypoxia/reoxygenation injury in neuroblastoma cells
- Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa
- BMAL1 regulates mitochondrial homeostasis in renal ischaemia‐reperfusion injury by mediating the SIRT1/PGC‐1α axis
- Obesity caused by a high-fat diet regulates the Sirt1/PGC-1α/FNDC5/BDNF pathway to exacerbate isoflurane-induced postoperative cognitive dysfunction in older …
- Impacts of aerobic exercise on depression-like behaviors in chronic unpredictable mild stress mice and related factors in the AMPK/PGC-1α pathway
- Nrf2 Activation Attenuates Chronic Constriction Injury-Induced Neuropathic Pain via Induction of PGC-1α-Mediated Mitochondrial Biogenesis in the Spinal …
- Tetramethylpyrazine nitrone improves motor dysfunction and pathological manifestations by activating the PGC-1α/Nrf2/HO-1 pathway in ALS mice
- Trpv4 regulates Nlrp3 inflammasome via SIRT1/PGC-1α pathway in a cuprizone-induced mouse model of demyelination
- GATA3 induces the upregulation of UCP-1 by directly binding to PGC-1α during adipose tissue browning
- Melatonin elicits protective effects on OGD/R‑insulted H9c2 cells by activating PGC-1α/Nrf2 signaling
- … effectiveness of continuous and interval exercise preconditioning against chronic unpredictable stress: Involvement of hippocampal PGC-1α/FNDC5/BDNF pathway
- Perindopril improves cardiac function by enhancing the expression of SIRT3 and PGC-1α in a rat model of isoproterenol-induced cardiomyopathy
- Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1α and JAK2/STAT3 signaling pathway in rats
- Ginsenoside Rd ameliorates auditory cortex injury associated with military aviation noise-induced hearing loss by activating SIRT1/PGC-1α signaling pathway
- PGC-1α regulates airway epithelial barrier dysfunction induced by house dust mite
- Sirtuin 1 alleviates microglia-induced inflammation by modulating the PGC-1α/Nrf2 pathway after traumatic brain injury in male rats
- Molecular basis of ventricular arrhythmogenicity in a PGC-1α deficient murine model
- Arsenic causes mitochondrial biogenesis obstacles by inhibiting the AMPK/PGC-1α signaling pathway and also induces apoptosis and dysregulated …
- Effects of bacteriophage supplement on the growth performance, microbial population, and PGC-1α and TLR4 gene expressions of broiler chickens
- Therapeutic potential of PGC-1α in age-related macular degeneration (AMD)–the involvement of mitochondrial quality control, autophagy, and antioxidant response
- IL-6 Deficiency Attenuates Skeletal Muscle Atrophy by Inhibiting Mitochondrial ROS Production through the Upregulation of PGC-1α in Septic Mice
- … on Neurodegeneration and Inflammation in d-Galactose-Induced Aging Mice with the Potential Mechanism Relying on AMPK/SIRT1/PGC-1α Pathway and Gut …
- Sulforaphane inhibits blue light–induced inflammation and apoptosis by upregulating the SIRT1/PGC-1α/Nrf2 pathway and autophagy in retinal pigment epithelial …
- Resveratrol increase the proportion of oxidative muscle fiber through the AdipoR1-AMPK-PGC-1α pathway in pigs
- Eplerenone reduces renal ischaemia/reperfusion injury by modulating Klotho, NF-κB and SIRT1/SIRT3/PGC-1α signalling pathways
- Alpha-Lipoic Acid Attenuates MPTP/MPP+-Induced Neurotoxicity: Roles of SIRT1-Dependent PGC-1α Signaling Pathways
- Melatonin improves mitochondrial function by preventing mitochondrial fission in cadmium-induced rat proximal tubular cell injury via SIRT1–PGC-1α pathway …
- Energy deprivation-induced AMPK activation inhibits milk synthesis by targeting PrlR and PGC-1α
- … of 5-heptadecylresorcinol against obesity-associated skeletal muscle dysfunction by modulating mitochondrial biogenesis via the activation of SIRT3/PGC-1α …
- Aspirin improves nonalcoholic fatty liver disease and atherosclerosis through regulation of the PPARδ-AMPK-PGC-1α pathway in dyslipidemic conditions
- Isosteviol sodium protects the cardiomyocyte response associated with the SIRT1/PGC‐1α pathway
- Resveratrol protects mitochondrial quantity by activating SIRT1/PGC‐1α expression during ovarian hypoxia
- The Acute Effects of Swimming Exercise on PGC-1α-FNDC5/Irisin-UCP1 Expression in Male C57BL/6J Mice
- Aldehyde dehydrogenase 2 alleviates mitochondrial dysfunction by promoting PGC-1α-mediated biogenesis in acute kidney injury
- PGC-1α activator–induced fatty acid oxidation in tumor-infiltrating CTLs enhances effects of PD-1 blockade therapy in lung cancer
- Melatonin relieves 2, 2, 4, 4-tetrabromodiphenyl ether (BDE-47)-induced apoptosis and mitochondrial dysfunction through the AMPK-Sirt1-PGC-1α axis in fish …
- MCU-dependent mROS generation regulates cell metabolism and cell death modulated by the AMPK/PGC-1α/SIRT3 signaling pathway
- PGC-1α Affects Epileptic Seizures by Regulating Mitochondrial Fusion in Epileptic Rats
- PGC-1α activates SIRT3 to modulate cell proliferation and glycolytic metabolism in breast cancer.
- Rational design, synthesis, and in vitro neuroprotective evaluation of novel glitazones for PGC-1α activation via PPAR-γ: a new therapeutic strategy for …
- BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice
- Down-regulation of betatrophin enhances insulin sensitivity in type 2 diabetes mellitus through activation of the GSK-3β/PGC-1α signaling pathway
- Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice
- Potential of Telomerase in Age-Related Macular Degeneration—Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α
- Function of hesperidin alleviating inflammation and oxidative stress responses in COPD mice might be related to SIRT1/PGC-1α/NF-κB signaling axis
- Rosmarinic acid ameliorated cardiac dysfunction and mitochondrial injury in diabetic cardiomyopathy mice via activation of the SIRT1/PGC-1α pathway
- miR-373 suppresses cell proliferation and apoptosis via regulation of SIRT1/PGC-1α/NRF2 axis in pancreatic cancer
- Aspirin alleviates denervation-induced muscle atrophy via regulating the Sirt1/PGC-1α axis and STAT3 signaling
- Ferulic acid suppresses interleukin‐1β‐induced degeneration of chondrocytes isolated from patients with osteoarthritis through the SIRT1/AMPK/PGC‐1α signaling …
- Forty high-intensity interval training sessions blunt exercise-induced changes in the nuclear protein content of PGC-1α and p53 in human skeletal muscle
- Lnc RNA GUARDIN suppresses cellular senescence through a LRP 130‐PGC 1α‐FOXO 4‐p21‐dependent signaling axis
- Paeoniflorin ameliorates skeletal muscle atrophy in chronic kidney disease via AMPK/SIRT1/PGC-1α-mediated oxidative stress and mitochondrial dysfunction
- Naringin induces skeletal muscle fiber type transformation via AMPK/PGC-1α signaling pathway in mice and C2C12 myotubes
- miR-22-3p regulates muscle fiber-type conversion through inhibiting AMPK/SIRT1/PGC-1α pathway
- The mTOR/PGC-1α/SIRT3 pathway drives reductive glutamine metabolism to reduce oxidative stress caused by ISKNV in CPB cells
- Sirt6 opposes glycochenodeoxycholate-induced apoptosis of biliary epithelial cells through the AMPK/PGC-1α pathway
- Seed oil of Rosa roxburghii Tratt against non-alcoholic fatty liver disease in vivo and in vitro through PPARα/PGC-1α-mediated mitochondrial oxidative metabolism
- Mitigation of doxorubicin-induced cardiotoxicity by dichloroacetate: potential roles of restoration of PGC-1α/SIRT3 signaling and suppression of oxidative stress …
- Post‐translational regulation of PGC‐1α modulates fibrotic repair
- Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway
- Herba houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade
- Adult conditional knockout of PGC-1α in GABAergic neurons causes exaggerated startle reactivity, impaired short-term habituation and hyperactivity
- RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates
- PGC‐1α attenuates TNF‐α‐induced inflammatory responses in OCCM‐30 cells
- The effect of antecedent-conditioning high-intensity interval training on BDNF regulation through PGC-1α pathway following cerebral ischemia
- Notoginseng Leaf Triterpenes Ameliorates OGD/R-Induced Neuronal Injury via SIRT1/2/3-Foxo3a-MnSOD/PGC-1α Signaling Pathways Mediated by the …
- Mitochondrial biogenesis factor PGC-1α suppresses spinal morphine tolerance by reducing mitochondrial superoxide
- Endoplasmic reticulum stress downregulates PGC-1α in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2
- Time-restricted feeding attenuates gluconeogenic activity through inhibition of PGC-1α expression and activity
- Heat‐induced changes in the expression and localisation of PGC‐1α in the mice testis
- … Huatan Decoction Ameliorates Myocardial Ischemia/Reperfusion Injury in Hyperlipidemic Rats via PGC-1α–PPARα and PGC-1α–NRF1–mtTFA Pathways
- Sea grapes extract improves blood glucose, total cholesterol, and PGC-1α in rats fed on cholesterol-and fat-enriched diet
- Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice
- Poncirin ameliorates cardiac ischemia-reperfusion injury by activating PI3K/AKT/PGC-1α signaling
- SIRT3 affects mitochondrial metabolic reprogramming via the AMPK–PGC‐1α axis in the development of benign prostatic hyperplasia
- Activation of SIRT1/PGC 1α/SIRT3 pathway by melatonin provides protection against mitochondrial dysfunction in isoproterenol induced myocardial injury
- Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ‐PPARγ/PGC‐1α signaling pathway
- Muscle PGC-1α modulates hepatic mitophagy regulation during aging
- Immunohistochemical analysis of PGC-1α and errα expression reveals their clinical significance in human ovarian cancer
- Ameliorative effect of betanin on experimental cisplatin‐induced liver injury; the novel impact of miRNA‐34a on the SIRT1/PGC‐1α signaling pathway
- Glucose-stimulated PGC-1α couples with CBP and Runx2 to mediate intervertebral disc degeneration through transactivation of ADAMTS4/5 in diet-induced obesity …
- Abdominal massage alleviates skeletal muscle insulin resistance by regulating the AMPK/SIRT1/PGC-1α signaling pathway
- … of Lycium barbarum Polysaccharide Combined with Aerobic Exercise Ameliorates High-Fat-Induced Nonalcoholic Steatohepatitis via AMPK/PPARα/PGC-1α …
- Long-term caloric restriction activates the myocardial SIRT1/AMPK/PGC-1α pathway in C57BL/6J male mice
- PGC-1α regulates cell proliferation and invasion via AKT/GSK-3β/β-catenin pathway in human colorectal cancer SW620 and SW480 cells
- Piceatannol promotes hepatic and renal AMPK/SIRT1/PGC-1α mitochondrial pathway in rats exposed to reserpine or gamma-radiation
- CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition
- Atractylenolide III from Atractylodes macrocephala Koidz promotes the activation of brown and white adipose tissue through SIRT1/PGC-1α signaling pathway
- Si-Miao-Yong-An decoction preserves cardiac function and regulates GLC/AMPK/NF-κB and GLC/PPARα/PGC-1α pathways in diabetic mice
- Sodium butyrate attenuates rotenone-induced toxicity by activation of autophagy through epigenetically regulating PGC-1α expression in PC12 cells
- PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis
- Protective effects of PGC-1α activators on ischemic stroke in a rat model of photochemically induced thrombosis
- The effects of Hemiscorpius lepturus induced-acute kidney injury on PGC-1α gene expression: From induction to suppression in mice
- Punicalagin Activates AMPK/PGC‐1α/Nrf2 Cascade in Mice: The Potential Protective Effect against Prenatal Stress
- ZLN005 Alleviates In Vivo and In Vitro Renal Fibrosis via PGC-1α-Mediated Mitochondrial Homeostasis
- The Anti-Aging Hormone Klotho Promotes Retinal Pigment Epithelium Cell Viability and Metabolism by Activating the AMPK/PGC-1α Pathway
- Isoliquiritigenin alleviates LPS/D-GalN-induced acute liver failure by activating the PGC-1α/Nrf2 pathway to reduce oxidative stress and inflammatory response
- Heat stress promotes lipid accumulation by inhibiting the AMPK-PGC-1α signaling pathway in 3T3-L1 preadipocytes
- PGC‐1α overexpression increases transcription factor EB nuclear localization and lysosome abundance in dystrophin‐deficient skeletal muscle
- PGC-1α-siRNA suppresses inflammation in substantia nigra of PD mice by inhibiting microglia
- Bisphenol-A mediated impaired DRP1-GFER axis and cognition restored by PGC-1α upregulation through nicotinamide in the rat brain hippocampus
- P2y2r deficiency ameliorates hepatic steatosis by reducing lipogenesis and enhancing fatty acid β-oxidation through ampk and PGC-1α induction in high-fat diet-fed …
- The PGC-1α/NRF1/miR-378a axis protects vascular smooth muscle cells from FFA-induced proliferation, migration and inflammation in atherosclerosis
- Dehydroepiandrosterone protects against hepatic glycolipid metabolic disorder and insulin resistance induced by high fat via activation of AMPK-PGC-1α-NRF-1 and …
- NRF2/PGC-1α-mediated mitochondrial biogenesis contributes to T-2 toxin-induced toxicity in human neuroblastoma SH-SY5Y cells
- Acute elevated resistin exacerbates mitochondrial damage and aggravates liver Steatosis through AMPK/PGC-1α signaling pathway in male NAFLD mice
- p53/PGC-1α‑mediated mitochondrial dysfunction promotes PC3 prostate cancer cell apoptosis
- PTEN regulates mitochondrial biogenesis via the AKT/GSK-3β/PGC-1α pathway in autism
- PGC-1α signaling increases GABA (A) receptor subunit α2 expression, GABAergic neurotransmission and anxiety-like behavior in mice
- … sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse …
- HPV E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis
- IL-10 ameliorates PM2. 5-induced lung injury by activating the AMPK/SIRT1/PGC-1α pathway
- … suppresses inflammation and blood‒brain barrier disruption in rats with vascular dementia possibly by activating the SIRT1/PGC-1α/PPARγ signaling pathway
- Protective effects of purple rice husk against diabetic nephropathy by modulating PGC-1α/sirt3/sod2 signaling and maintaining mitochondrial redox equilibrium in rats
- Depression of mitochondrial function in the rat skeletal muscle model of myofascial pain syndrome is through down-regulation of the AMPK-PGC-1α-SIRT3 axis
- … -selective HDAC inhibitor mocetinostat (MGCD0103) alleviates myocardial ischemia/reperfusion injury via mitochondrial protection through the HDACs/CREB/PGC-1α …
- Glitazones Activate PGC-1α Signaling via PPAR-γ: A Promising Strategy for Antiparkinsonism Therapeutics.
- YY1 inactivated transcription co-regulator PGC-1α to promote mitochondrial dysfunction of early diabetic nephropathy-associated tubulointerstitial fibrosis
- Elucidation of SIRT-1/PGC-1α-associated mitochondrial dysfunction and autophagy in nonalcoholic fatty liver disease
- Baicalin ameliorates CUMS-induced depression-like behaviors through activating AMPK/PGC-1α pathway and enhancing NIX-mediated mitophagy in mice
- … the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK/SIRT1/PGC-1α …
- Arbutin Protects Retinal Pigment Epithelium Against Oxidative Stress by Modulating SIRT1/FOXO3a/PGC-1α/β Pathway
- … pentaphyllum extract and Gypenoside L enhance skeletal muscle differentiation and mitochondrial metabolism by activating the PGC-1α pathway in C2C12 …
- Metabolic consequences of PGC-1α dysregulation in adult zebrafish muscle
- Srebp-1c/Fgf21/PGC-1α Axis regulated by leptin signaling in adipocytes—possible mechanism of caloric restriction-associated metabolic remodeling of white adipose …
- Liraglutide ameliorates gentamicin-induced acute kidney injury in rats via PGC-1α-mediated mitochondrial biogenesis: Involvement of PKA/CREB and Notch/Hes-1 …
- The role of PGC‐1α and metabolic signaling pathway in kidney injury following chronic administration with 3‐MCPD as a food processing contaminant
- PGC-1α and ERRα in patients with endometrial cancer: a translational study for predicting myometrial invasion
- Morroniside promotes PGC-1α-mediated cholesterol efflux in sodium palmitate or high glucose-induced mouse renal tubular epithelial cells
- Astragaloside IV reverses simvastatin‐induced skeletal muscle injury by activating the AMPK‐PGC‐1α signalling pathway
- Norisoboldine attenuates sepsis-induced acute lung injury by modulating macrophage polarization via PKM2/HIF-1α/PGC-1α pathway
- Melatonin-Induced PGC-1α Improves Angiogenic Potential of Mesenchymal Stem Cells in Hindlimb Ischemia
- Iprodione and/or chlorpyrifos exposure induced testicular toxicity in adult rats by suppression of steroidogenic genes and SIRT1/TERT/PGC-1α pathway
- An Association Between FNDC5, PGC-1α Genetic Variants and Obesity in Chinese Children: A Case-Control Study
- AMPK/PGC-1α/GLUT4-mediated effect of icariin on hyperlipidemia-induced non-alcoholic fatty liver disease and lipid metabolism disorder in mice
- The neuroprotective role of SIRT1/PGC-1α signaling in limb postconditioning in cerebral ischemia/reperfusion injury
- Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1α Pathway
- Regulation of metabolism during hibernation in brown bears (Ursus arctos): involvement of cortisol, PGC-1α and AMPK in adipose tissue and skeletal muscle
- Teaghrelin Protects SH-SY5Y Cells against MPP+-Induced Neurotoxicity through Activation of AMPK/SIRT1/PGC-1α and ERK1/2 Pathways
- Shen Shuai Ⅱ Recipe attenuates renal fibrosis in chronic kidney disease by improving hypoxia-induced the imbalance of mitochondrial dynamics via PGC-1α …
- Intranasal 15d-PGJ2 ameliorates brain glucose hypometabolism via PPARγ-dependent activation of PGC-1α/GLUT4 signalling in APP/PS1 transgenic mice
- Activation of PGC‐1α via isoliquiritigenin‐induced downregulation of miR‐138‐5p alleviates nonalcoholic fatty liver disease
- PGC-1α-mediated mitochondrial quality control: molecular mechanisms and implications for heart failure
- Qiangji Jianli decoction promotes mitochondrial biogenesis in skeletal muscle of myasthenia gravis rats via AMPK/PGC-1α signaling pathway
- Resveratrol Reestablishes Mitochondrial Quality Control in Myocardial Ischemia/Reperfusion Injury through Sirt1/Sirt3-Mfn2-Parkin-PGC-1α Pathway
- … improves insulin sensitivity and promotes adipose thermogenesis in diet-induced obese mice associated with activation of PGC-1α-FNDC5/irisin pathway
- Shen Qi Li Xin formula improves chronic heart failure through balancing mitochondrial fission and fusion via upregulation of PGC-1α
- Insulin injections inhibits PTZ-induced mitochondrial dysfunction, oxidative stress and neurological deficits via the SIRT1/PGC-1α/SIRT3 pathway
- PGC-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging
- Graded reductions in pre‐exercise glycogen concentration do not augment exercise‐induced nuclear AMPK and PGC‐1α protein content in human muscle
- SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/PGC-1α positive feedback loop
- Metabolomic analysis on blood of transgenic mice overexpressing PGC-1α in skeletal muscle
- … phenolic extract confers protective effects against alcoholic liver disease in mice by alleviating mitochondrial dysfunction via the PGC-1α-TFAM pathway mediated by …
- Effect of selenium supplementation on expression of SIRT1 and PGC-1α genes in ulcerative colitis patients: a double blind randomized clinical trial
- … Antioxidative Capability and Promotes Mitochondrial Biogenesis in D-Galactose-Induced Aging Mice by Increasing Nrf2 and PGC-1α through the cAMP …
- PGC-1α regulate critical period plasticity via gene× environment interaction in the developmental trajectory to schizophrenia
- PGC-1α Is a Master Regulator of Mitochondrial Lifecycle and ROS Stress Response
- Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1α pathway
- PGC-1α promotes mitochondrial respiration and biogenesis during the differentiation of hiPSCs into cardiomyocytes
- PGC-1α in mediating mitochondrial biogenesis and intestinal epithelial differentiation promoted by purple potato extract
- … protective effects of α-Mangostin attenuate sodium iodate-induced cytotoxicity and oxidative injury via mediating SIRT-3 inactivation via the PI3K/AKT/PGC-1α …
- Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia …
- Cross-talk between TRPC-1, mTOR, PGC-1α and PPARδ in the dystrophic muscle cells treated with tempol
- Effect of feeding regimen on meat quality, MyHC isoforms, AMPK, and PGC‐1α genes expression in the biceps femoris muscle of Mongolia sheep
- Dual Role of Phenyl Amides from Hempseed on BACE 1, PPARγ, and PGC-1α in N2a-APP Cells
- Jieduquyuziyin Prescription alleviates hepatic gluconeogenesis via PI3K/Akt/PGC-1α pathway in glucocorticoid-induced MRL/lpr mice
- The effect of Crocin on TFAM and PGC-1α expression and Catalase and Superoxide dismutase activities following cholestasis-induced neuroinflammation in the …
- Protective effect of Jiang Tang Xiao Ke Granules against skeletal muscle IR via activation of the AMPK/SIRT1/PGC-1α signaling pathway
- A novel gravity-induced blood flow restriction model augments ACC phosphorylation and PGC-1α mRNA in human skeletal muscle following aerobic exercise: a …
- Betulinic acid decreases lipid accumulation in adipogenesis-induced human mesenchymal stem cells with upregulation of PGC-1α and UCP-1 and post …
- … -survival properties of safinamide against methamphetamine-induced neurodegeneration: Hypothetic possible role of BDNF/TrkB/PGC-1α signaling pathway and …
- Glucagon Promotes Gluconeogenesis through the GCGR/PKA/CREB/PGC-1α Pathway in Hepatocytes of the Japanese Flounder Paralichthys olivaceus
- Association of Irisin/FNDC5 with ERRα and PGC-1α Expression in NSCLC
- Faster lipid β‐oxidation rate by acetyl‐CoA carboxylase 2 inhibition alleviates high‐glucose‐induced insulin resistance via SIRT1/PGC‐1α in human podocytes
- Constitutive PGC-1α overexpression in skeletal muscle does not contribute to exercise-induced neurogenesis
- Maternal zinc alleviates tert-butyl hydroperoxide-induced mitochondrial oxidative stress on embryonic development involving the activation of Nrf2/PGC-1α …
- Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury
- Reactive Oxygen Species Control Osteoblast Apoptosis through SIRT1/PGC-1α/P53Lys382 Signaling, Mediating the Onset of Cd-Induced Osteoporosis
- Epithelial SMYD5 Exaggerates IBD by Down-regulating Mitochondrial Functions via Post-Translational Control of PGC-1α Stability
- Rosmarinic acid protects against lipopolysaccharide‐induced cardiac dysfunction via activating Sirt1/PGC‐1α pathway to alleviate mitochondrial impairment
- Effect of cholestasis and NeuroAid treatment on the expression of Bax, Bcl-2, PGC-1α and Tfam genes involved in apoptosis and mitochondrial biogenesis in the …
- Cardiomyocyte-restricted high-mobility group box 1 (HMGB1) deletion leads to small heart and glycolipid metabolic disorder through GR/PGC-1α signalling
- Zinc is essential for the transcription function of the PGC-1α/Nrf2 signaling pathway in human primary endometrial stromal cells
- Sp1 Inhibits PGC-1α via HDAC2-Catalyzed Histone Deacetylation in Chronic Constriction Injury-Induced Neuropathic Pain
- Resveratrol attenuates hyperoxia lung injury in neonatal rats by activating SIRT1/PGC-1α signaling pathway
- Celastrol regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing PGC-1α signaling
- Studies on the mechanism of energy metabolism via AMPK/PGC‐1α signaling pathway induced by compatibility of Ligusticum chuanxiong Hort and Gastrodia
- Role of Estrogen-Related Receptor γ and PGC-1α/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage
- Role of swimming on muscle PGC-1α, FNDC5 mRNA, and assessment of serum omentin, adropin, and irisin in high carbohydrate high fat (HCHF) diet …
- SESN2 prevents the slow-to-fast myofiber shift in denervated atrophy via AMPK/PGC-1α pathway
- The expression of liver metabolic enzymes ampkα1, ampkα2, and PGC-1α due to exercise in Type-2 diabetes mellitus rat model
- Bisphenol A exposure induces metastatic aggression in low metastatic MCF-7 cells via PGC-1α mediated mitochondrial biogenesis and epithelial-mesenchymal …
- Antifatigue effects of anshenyizhi compound in acute excise‐treated mouse via modulation of AMPK/PGC‐1α‐related energy metabolism and Nrf2/ARE‐mediated …
- Alzheimer’s and Parkinson’s brain tissues have reduced expression of genes for mtDNA OXPHOS Proteins, mitobiogenesis regulator PGC-1α protein and mtRNA …
- Dexmedetomidine Exerts Renal Protective Effect by Regulating the PGC-1α/STAT1/IRF-1 Axis
- Phosphocreatine promotes osteoblastic activities in H2O2-induced MC3T3-E1 cells by regulating SIRT1/FOXO1/PGC-1α signaling pathway
- PGC-1α Regulates Cell Proliferation, Migration, and Invasion by Modulating Leucyl-tRNA Synthetase 1 Expression in Human Colorectal Cancer Cells
- Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover
- Placental insulin/IGF-1 signaling, PGC-1α, and inflammatory pathways are associated with metabolic outcomes at 4–6 years of age: the ECHO healthy start cohort
- Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling
- The anti-fatigue effect of the Auxis thazard oligopeptide via modulation of the AMPK/PGC-1α pathway in mice
- Remote ischemic preconditioning protects against spinal cord ischemia–reperfusion injury in mice by activating NMDAR/AMPK/PGC-1α/SIRT3 signaling
- Translocator Protein (TSPO) Alleviates Neuropathic Pain by Activating Spinal Autophagy and Nuclear SIRT1/PGC-1α Signaling in a Rat L5 SNL Model
- Periplaneta americana extract ameliorates lipopolysaccharide‑induced liver injury by improving mitochondrial dysfunction via the AMPK/PGC-1α signaling …
- Promotion of mitochondrial biogenesis via the regulation of PARIS and PGC-1α by parkin as a mechanism of neuroprotection by carnosic acid
- Matrine counteracts obesity in mice via inducing adipose thermogenesis by activating HSF1/PGC-1α axis
- PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice
- Positive regulation of TFEB and mitophagy by PGC-1α to alleviate LPS-induced acute lung injury in rats
- The effect of high-intensity interval training on the expression levels of PGC-1α and SIRT3 proteins and aging index of slow-twitch and fast-twitch of healthy male rats
- Survival pathways of HIF-deficient tumour cells: TCA inhibition, peroxisomal fatty acid oxidation activation and an AMPK-PGC-1α hypoxia sensor
- von Hippel-Lindau-targeting microRNA-143–3p attenuates mitochondrial abnormality via AMPK/PGC-1α axis in Parkinson’s disease
- RORA alleviates LPS-induced apoptosis of renal epithelial cells by promoting PGC-1α transcription
- NT-PGC-1α deficiency attenuates high-fat diet-induced obesity by modulating food intake, fecal fat excretion and intestinal fat absorption
- Naringenin promoted spinal microglia M2 polarization in rat model of cancer-induced bone pain via regulating AMPK/PGC-1α signaling axis
- Citrus hassaku Extract Powder Increases Mitochondrial Content and Oxidative Muscle Fibers by Upregulation of PGC-1α in Skeletal Muscle
- Genetic Variants of VDR and PGC-1α Are Not Associated with the Risk of Endometriosis in Indian Women
- Nanoparticle endothelial delivery of PGC-1α attenuates hypoxia-induced pulmonary hypertension by attenuating EndoMT-caused vascular wall remodeling
- Hepatic Gadd45β promotes hyperglycemia and glucose intolerance through DNA demethylation of PGC-1α
- TLR4 knockout upregulates the expression of Mfn2 and PGC-1α in a high-fat diet and ischemia-reperfusion mice model of liver injury
- Effect of 12-wk Training in Ovariectomised Rats on PGC-1α, NRF-1 and Energy Substrates
- Luteolin increases slow muscle fibers via FLCN-AMPK-PGC-1α signaling pathway
- Hypoxia preconditioning improves structure and function of astrocytes mitochondria via PGC-1α/HIF signal
- … 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α …
- Melatonin attenuates bisphenol A-induced colon injury by dual targeting mitochondrial dynamics and Nrf2 antioxidant system via activation of SIRT1/PGC-1α signaling …
- AMPK Regulates DNA Methylation of PGC-1α and Myogenic Differentiation in Human Mesenchymal Stem Cells
- PGC-1α/NRF1-dependent cardiac mitochondrial biogenesis: A druggable pathway of calycosin against triptolide cardiotoxicity
- Exchange protein directly activated by cAMP (Epac) 1 plays an essential role in stress-induced exercise capacity by regulating PGC-1α and fatty acid metabolism in …
- Design and Development of Novel Glitazones for Activation of PGC-1α Signaling Via PPAR-γ Agonism: A Promising Therapeutic Approach against Parkinson’s …
- Activating PGC-1α-mediated signaling cascades in the aorta contributes to the amelioration of vascular senescence and atherosclerosis by 2, 3, 4′, 5 …
- Simvastatin Impairs Glucose Homeostasis in Mice Depending on PGC-1α Skeletal Muscle Expression
- N-acetylserotonin inhibits oxidized mitochondrial DNA-induced neuroinflammation by activating the AMPK/PGC-1α/TFAM pathway in neonatal hypoxic-ischemic brain …
- Training protocols differently affect AMPK–PGC-1α signaling pathway and redox state in trout muscle
- Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α Overexpression
- DT-010 Exerts Cardioprotective Effects by Regulating the Crosstalk between the AMPK/PGC-1α Pathway and ERp57
- PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic …
- PGC-1α haploinsufficiency promotes pain chronification after burn injury
- Phthalate induces mitochondrial injury in cerebellum through Sirt1-PGC-1α and PINK1/Parkin-mediated signal pathways
- Indirubin-3′-oxime (IDR3O) inhibits proliferation of osteosarcoma cells in vitro and tumor growth in vivo through AMPK-activation and PGC-1α/TFAM up-regulation
- Activation of CB1R-Dependent PGC-1α Is Involved in the Improved Mitochondrial Biogenesis Induced by Electroacupuncture Pretreatment
- Nr2f2 Overexpression Aggravates Ferroptosis and Mitochondrial Dysfunction by Regulating the PGC-1α Signaling in Diabetes-Induced Heart Failure Mice
- Gain-of-Function p53N236S Mutation Drives the Bypassing of HRasV12-Induced Cellular Senescence via PGC–1α
- Alpha‐Asarone modulates kynurenine disposal in muscle and mediates resilience to stress‐induced depression via PGC‐1α induction
- Hepatic PGC-1α has minor regulatory effect on the liver transcriptome and metabolome during high fat high fructose diet and exercise training
- Correction to: YY1 inactivated transcription co‐regulator PGC‐1α to promote mitochondrial dysfunction of early diabetic nephropathy‐associated tubulointerstitial …
- PGC-1α in the myofibers regulates the balance between myogenic and adipogenic progenitors affecting muscle regeneration
- Empagliflozin attenuates doxorubicin-induced cardiotoxicity by activating AMPK/SIRT-1/PGC-1α-mediated mitochondrial biogenesis
- PGC-1α and MEF2 Regulate the Transcription of the Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle
- Magnolol alleviates IL-1β-induced dysfunction of chondrocytes through repression of SIRT1/AMPK/PGC-1α signaling pathway
- D-allulose ameliorates adiposity through the AMPK-SIRT1-PGC-1α pathway in HFD-induced SD rats
- PPAR-γ Activation Alleviates Osteoarthritis through Both the Nrf2/NLRP3 and PGC-1α/Δψm Pathways by Inhibiting Pyroptosis
- Quercetin Reprograms Immunometabolism of Macrophages via the SIRT1/PGC-1α Signaling Pathway to Ameliorate Lipopolysaccharide-Induced Oxidative …
- Aspirin alleviates cisplatin-induced acute kidney injury through the AMPK-PGC-1α signaling pathway
- Conditional deletion of PGC-1α results in energetic and functional defects in NK cells
- Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell …
- Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway
- Garcinol protects SH‐SY5Y cells against MPP+‐induced cell death by activating DJ‐1/SIRT1 and PGC‐1α mediated antioxidant pathway in sequential stimulation of p …
- PGC-1α gene transfer restores adhesion and reendothelialization of endothelial progenitor cells from patients with hypertension
- Inhibition of the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α)/sirtuin 3 (SIRT3) pathway aggravates oxidative stress after …
- Baoyuan Jiedu decoction alleviates cancer-induced myotube atrophy by regulating mitochondrial dynamics through p38 MAPK/PGC-1α signaling pathway
- PGC-1α deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice
- An original amino acid formula favours in vitro corneal epithelial wound healing by promoting Fn1, ITGB1, and PGC-1α expression
- Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) overexpression alleviates endoplasmic reticulum stress after acute kidney injury
- SIRT1/PGC-1α is involved in arsenic-induced male reproductive damage through mitochondrial dysfunction, which is blocked by the antioxidative effect of zinc
- QKI 6 ameliorates CIRI through promoting synthesis of triglyceride in neuron and inhibiting neuronal apoptosis associated with SIRT1‐PPARγ‐PGC‐1α axis
- The adverse effects of hypoxia on hiHep functions via HIF-1α/PGC-1α axis are alleviated by PFDC emulsion
- Dihydromyricetin ameliorates diet-induced obesity and promotes browning of white adipose tissue by upregulating IRF4/PGC-1α
- Anti-TWEAK antibody alleviates renal interstitial fibrosis by increasing PGC-1α expression in lupus nephritis
- Ameliorative effect of Lactobacillus rhamnosus GG on acetaminophen-induced hepatotoxicity via PKC/Nrf2/PGC-1α pathway
- Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration
- SS31 Confers Cerebral Protection by Reversing Mitochondrial Dysfunction in Early Brain Injury Following Subarachnoid Hemorrhage, via the Nrf2-and PGC-1α …
- Diet Control and Swimming Exercise Ameliorate HFD-Induced Cognitive Impairment Related to the SIRT1-NF-κB/PGC-1α Pathways in ApoE-/- Mice
- Role of PGC-1α mediated synaptic plasticity, mitochondrial function, and neuroinflammation in the antidepressant effect of Zi-Shui-Qing-Gan-Yin
- Genetic ablation of aldehyde reductase (Akr1a) augments exercise endurance in mice via activation of the PGC-1α-involved pathway
- PPRC1, but not PGC-1α, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts
- … /pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polarization, and AMPK/SIRT-1/PGC-1α …
- Knockdown of Sirt1 Gene in Mice Results in Lipid Accumulation in the Liver Mediated via PGC-1α-Induced Mitochondrial Dysfunction and Oxidative Stress
- Effects of Treadmill Exercise on the Expression Level of BAX, BAD, BCL-2, BCL-XL, TFAM, and PGC-1α in the Hippocampus of Thimerosal-Treated Rats
- Salvianolic acid A promotes mitochondrial biogenesis and function via regulating the AMPK/PGC-1α signaling pathway in HUVECs
- β1 adrenoceptor antibodies induce myocardial apoptosis via inhibiting PGC-1α-related pathway
- Oxidative stress and mitochondrial damage in dry age-related macular degeneration like NFE2L2/PGC-1α-/-mouse model evoke complement component C5a …
- Icariside II, a Naturally Occurring SIRT3 Agonist, Protects against Myocardial Infarction through the AMPK/PGC-1α/Apoptosis Signaling Pathway
- 17beta-estradiol alleviates contusion-induced skeletal muscle injury by decreasing oxidative stress via SIRT1/PGC-1α/Nrf2 pathway
- Lipoxin A4 attenuated dexamethasone-induced muscle atrophy via activation of PGC-1α/Nrf2/TFAM pathway
- Cordycepin exhibits anti-fatigue effect via activating TIGAR/SIRT1/PGC-1α signaling pathway
- SIRT3 ameliorates polycystic ovary syndrome through FOXO1/PGC-1α signaling pathway
- Basolateral amygdala SIRT1/PGC-1α mitochondrial biogenesis pathway mediates morphine withdrawal-associated anxiety in mice
- Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway
- The role of PGC-1α in digestive system malignant tumours
- Dietary L-arginine supplementation influences the muscle fiber characteristics and meat quality of Mongolian sheep through the NO/AMPK/PGC-1α pathway
- VGLL3 confers slow-twitch muscle differentiation via PGC-1α expression in C2C12 myocytes
- … Medicine Formula: Yinhuo Decoction Antagonizes the Damage of Corticosterone to PC12 Cells and Improves Depression by Regulating the SIRT1/PGC-1α …
- The effect of crocin on cholestasis-induced spatial memory impairment with respect to the expression level of TFAM and PGC-1α and activity of catalase and …
- Downregulation of miR-761 ameliorates radiation-induced pulmonary fibrosis by regulating PGC-1α
- Low-Nutrient Environment-Induced Changes in Inflammation, Cell Proliferation, and PGC-1α Expression in Stromal Cells with Ovarian Endometriosis
- San-Huang-Tang protects obesity/diabetes induced NAFLD by upregulating PGC-1α/PEPCK signaling in obese and galr1 knockout mice models
- … (the dried rhizome of Acorus tatarinowii Schott) prevents hydrogen peroxide-induced cell injury in PC12 cells: a signaling triggered by CREB/PGC-1α …
- ∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1α Axis
- Cholecystokinin Octapeptide Promotes ANP Secretion through Activation of NOX4–PGC-1α–PPARα/PPARγ Signaling in Isolated Beating Rat Atria
- Changes in PGC-1α-Dependent Mitochondrial Biogenesis Are Associated with Inflexible Hepatic Energy Metabolism in the Offspring Born to Dexamethasone-Treated …
- Exposure to dipentyl phthalate in utero disrupts the adrenal cortex function of adult male rats by inhibiting SIRT1/PGC‐1α and inducing AMPK phosphorylation
- Role of PGC‐1α in fiber type conversion in the palatopharyngeus muscle of OSA patients
- Epigenetic control of mitochondrial fission enables hepatic stellate cells activation in liver fibrosis via PGC-1α-Drp1 pathway
- Beneficial effects of quercetin on vincristine‐induced liver injury in rats: Modulating the levels of Nrf2/HO‐1, NF‐kB/STAT3, and SIRT1/PGC‐1α
- Research progress of effect and mechanism of PGC-1α in cardiovascular diseases
- … a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via PGC-1α, Il-6, and …
- Metabolic adaptations in spontaneously immortalized PGC-1α knock-out mouse embryonic fibroblasts increase their oncogenic potential
- Activation of AMPK-PGC-1α pathway ameliorates peritoneal dialysis related peritoneal fibrosis in mice by enhancing mitochondrial biogenesis
- Mitochondrial energy metabolism is downregulated in repeated implantation failure patients related to alteration of PGC‐1α acetylation level
- Perilipin Isoforms and PGC-1α Are Regulated Differentially in Rat Heart during Pregnancy-Induced Physiological Cardiac Hypertrophy
- Effect of icariin on the H2O2-induced proliferation of mouse airway smooth muscle cells through miR-138-5p regulating SIRT1/AMPK/PGC-1α axis
- Nesfatin-1 alleviates hyperoxia-induced lung injury in newborn mice by inhibiting oxidative stress through regulating SIRT1/PGC-1α pathway
- Measuring PGC-1α and Its Acetylation Status in Mouse Primary Myotubes
- Hepatic PGC-1α is not essential for fasting-induced cytochrome p450 regulation in mouse liver
- SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α
- Effect of eight weeks of aerobic progressive training with capsaicin on changes in PGC-1α and UPC-1 expression in visceral adipose tissue of obese rats with …
- Chronic voluntary wheel running exercise ameliorates metabolic dysfunction via PGC-1α expression independently of FNDC5/irisin pathway in high fat diet …
- Changes in Serum Levels and Gene Expression of PGC-1α in The Cardiac Muscle of Diabetic Rats: The Effect of Dichloroacetate and Endurance Training
- Stiffer-Matrix-Induced PGC-1α Upregulation Enhanced Mitochondrial Biogenesis and Oxidative Stress Resistance in Non-small Cell Lung Cancer
- Effects of a yeast cell wall product on the performance of broiler chickens and PGC-1α, TLR4, IL-10 and PPARγ genes expression
- Salvianolic Acid B Alleviates Myocardial Ischemia Injury by Suppressing NLRP3 Inflammasome Activation via SIRT1-AMPK-PGC-1α Signaling Pathway
- β1-Adrenoceptor antibodies induce PPCM via inhibition of PGC-1α related pathway
- Hydrogen sulfide alleviates heart failure with preserved ejection fraction in mice by targeting mitochondrial abnormalities via PGC-1α
- Cumulative effect of cardiovascular risk factors on regulation of AMPK/SIRT1-PGC-1α-SIRT3 pathway in the human erectile tissue
- SUMOylation of SIRT1 activating PGC-1α/PPARα pathway mediates the protective effect of LncRNA-MHRT in cardiac hypertrophy
- High expressions of the cytoglobin and PGC-1α genes during the tissue regeneration of house gecko (Hemidactylus platyurus) tails
- Advanced Glycation End Products Induced Mitochondrial Dysfunction of Chondrocytes through Repression of AMPKα-SIRT1-PGC-1α Pathway
- PGC-1α Promotes Phosphorylation, Inflammation, and Apoptosis in H9c2 Cells During the Early Stage of Lipopolysaccharide Induction
- Effects of Hypoxic and Normoxic Training in Altitude on HIF-1α and PGC-1α Levels in Elite Endurance Runners
- The master energy homeostasis regulator PGC-1α couples transcriptional co-activation and mRNA nuclear export
- Nucleolin protects cardiomyocytes by upregulating PGC-1α and promoting mitochondrial biogenesis in LPS-induced myocardial injury
- Mitoprotective effect of mesenchymal stem cells-derived conditioned medium in myocardial reperfusion injury of aged rats: role of SIRT-1/PGC-1α/NRF-2 network
- Maternal nicotine exposure impairs brown adipose tissue via AMPK-SIRT1-PGC-1α signals in male offspring
- Bovine-derived MFG-E8 alleviating mitochondrial dysfunction via Akt/Sirt1/PGC-1α and MAPK/ERK signaling cascades
- Protein kinase C beta relieves autism‐like behavior in EN2 knockout mice via upregulation of the FTO/PGC‐1α/UCP1 axis
- Plin5 inhibits proliferation and migration of vascular smooth muscle cell through interacting with PGC-1α following vascular injury
- S-nitrosylated PARIS Leads to the Sequestration of PGC-1α into Insoluble Deposits in Parkinson’s Disease Model
- San-Huang-Chai-Zhu Formula Ameliorates Liver Injury in Intrahepatic Cholestasis through Suppressing SIRT1/PGC-1α-Regulated Mitochondrial Oxidative …
- NRG1/ErbB2 axis regulated mitochondrial function and antioxidant enzymes of neural stem cells in the cochlear nucleus partially through PGC-1α
- Methyltransferase SMYD5 Exaggerates IBD by Downregulating Mitochondrial Functions via Post-translational Control of PGC-1α Stability
- Adenosine receptor A1 enhanced mitochondrial biogenesis and exerted neuroprotection after cerebral ischemia through PGC-1α
- [Corrigendum] miR‑29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1α signaling: Implications for age‑related hearing …
- Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors
- Characterization of Age-dependent Behavior Deficits in the PGC-1α Knockout Mouse, in Relevance to the Parkinson’s Disease Model
- Potential Role of Peroxisome Proliferator-activated Receptor Gamma Coactivator-1 Alpha (PGC-1α) Gene Polymorphism in Patients with Type 2 Diabetes Mellitus
- The β3 adrenergic receptor agonist CL316243 ameliorates the metabolic abnormalities of high-fat diet-fed rats by activating AMPK/PGC-1α signaling in skeletal …
- … thymol ester inhibits melanogenesis in normal human melanocytes and 3D human epidermal equivalents via the PGC-1α-independent PPARγ partial agonism
- Perampanel stimulates mitochondrial biogenesis in neuronal cells through activation of the SIRT1/PGC-1α signaling pathway
- Silent information regulator 1 ameliorates oxidative stress injury via PGC-1α/PPARγ-Nrf2 pathway after ischemic stroke in rat
- PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model
- Insufficient sleep disrupts glucose metabolism during pregnancy by inhibiting PGC-1α
- Morinda officinalis polysaccharide attenuates osteoporosis in rats underwent bilateral ovariectomy by suppressing the PGC-1α/PPARγ pathway
- FGF19 improves sevoflurane-induced cognitive dysfunction in rats through the PGC-1α/BDNF/FNDC5 pathway
- PGC-1α differentially regulates the mRNA expression profiles of genes related to myofiber type specificity in chicken
- Protective effects of PGC-1α on the blood brain barrier after acute kidney injury
- Calorie Restriction Combined with High-Intensity Interval Training Promotes Browning of White Adipose Tissue by Activating the PPARγ/PGC-1α/UCP1 …
- Aerobic exercise ameliorates myocardial ischemia/reperfusion injury and thrombosis of diabetic rats via activation of AMPK/Sirt1/PGC-1α pathway.
- PGC-1α attenuates the oxidative stress-induced impaired osteogenesis and angiogenesis regulation effects of mesenchymal stem cells in the presence of …
- Stimulating the sir2-PGC-1α axis rescues exercise capacity and mitochondrial respiration in Drosophila tafazzin mutants
- HypERlnc attenuates angiotensin II‐induced cardiomyocyte hypertrophy via promoting SIRT1 SUMOylation‐mediated activation of PGC‐1α/PPARα pathway in AC16 …
- PGC-1α is an exercise-responsive regulator of myosteatosis in older individuals
- Anti-oxidant effect of metformin through AMPK/SIRT1/PGC-1α/SIRT3–independent GPx1 expression in the heart of mice with endometriosis
- PGC 1α-Mediates Mitochondrial Damage in the Liver by Inhibiting the Mitochondrial Respiratory Chain as a Non-cholinergic Mechanism of Repeated Low …
- Metabolically flexible CAR T cells (mfCAR-T), with constitutive expression of PGC-1α resistant to post translational modifications, exhibit superior survival and …
- Effects of NRF-1 and PGC-1α cooperation on HIF-1α and rat cardiomyocyte apoptosis under hypoxia
- Protective effects of 6-Gingerol on cardiotoxicity induced by arsenic trioxide through AMPK/SIRT1/PGC-1α signaling pathway
- Edaravone prevents high glucose-induced injury in retinal Müller cells through thioredoxin1 and the PGC-1α/NRF1/TFAM pathway
- Effects of quercetin on hepatic fibroblast growth factor-21 (FGF-21) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) levels in rats …
- Tryptophan alleviates lipopolysaccharide-induced muscle fiber type transformation from type I to II and modulates Sirt1/AMPK/PGC-1α signaling pathway in pigs
- The effect of aerobic exercise training on hypoxia condition through PGC-1α angiogenesis signaling pathway in heart tissue of male westar rats
- The effect of neuroaid (MLC901) on cholestasis-induced spatial memory impairment with respect to the expression of BAX, BCL-2, BAD, PGC-1α and TFAM genes in …
- Curcumin relieves corticosterone‐induced behaviour deficits via PGC‐1α‐mediated mitochondrial biogenesis and mitophagy
- … : Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling …
- Overexpression of PGC-1α reduces inflammation and protects against focal cerebral ischaemia/reperfusion injury
- Curcumin attenuates isoniazid‐induced hepatotoxicity by upregulating the SIRT1/PGC‐1α/NRF1 pathway
- Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1α -/- Mouse Model Evoke Complement Component C5a …
- Mechanism of Zexie Decoction in improvement of nonalcoholic fatty liver disease based on LKB1/AMPK/PGC-1α pathway
- Garcinol Promotes the Formation of Slow-Twitch Muscle Fibers by Inhibiting p300-Dependent Acetylation of PGC-1α
- Correction: Kavain Reduces Porphyromonas gingivalis–Induced Adipocyte Inflammation: Role of PGC-1α Signaling
- Bioactive Oligopeptides from Ginseng (Panax ginseng Meyer) Suppress Oxidative Stress-Induced Senescence in Fibroblasts via NAD+/SIRT1/PGC-1α …
- Effect of electroacupuncture invention on activities of PGC-1α/Irisin (FNDC5)/BDNF signaling in cerebral cortex, hippocampus and muscles in focal cerebral ischemic …
- Effect of Endurance Training and MitoQ on Expression of PGC-1α, ERR-α, MCAD, and CPT-1α Genes in Skeletal Muscle of Male Wistar Rats
- Inhibition of osteosarcoma cell proliferation in vitro and tumor growth in vivo in mice model by alstonine through AMPK-activation and PGC-1α/TFAM up-regulation
- Berberine Ameliorates Cognitive Disorder via GSK3β/PGC-1α Signaling in APP/PS1 Mice
- Relationship Between Myocardial Injury and Expression of PGC-1α and Its Coactivators in Chronic Keshan Disease
- miR‑382 inhibits breast cancer progression and metastasis by affecting the M2 polarization of tumor‑associated macrophages by targeting PGC-1α
- … effect of eight weeks of high-intensity interval training vs. continuous training on serum Irisin levels and expression of skeletal muscle PGC-1α gene in male …
- Human papilloma virus E6 regulates therapy responses in oropharyngeal cancer by repressing the PGC-1α/ERRα axis
- The acute effects of high intensity interval training (HIIIT) on PGC-1α and FNDC5 genes expression in diabetic rats
- Down-regulation of SIRT1 and PGC-1α expression caused by hyperoxia induces mitochondrial dysfunction in human alveolar epithelial cells
- Angiotensin II-mediated improvement of renal mitochondrial function via the AMPK/PGC-1α/NRF-2 pathway is superior to norepinephrine in a rat model of …
- The effect of eight weeks of aerobic exercise with moderate and high intensities on serum irisin and PGC-1α protein levels in obese male Wistar rats
- Free fatty acid-induced miR-22 inhibits gluconeogenesis via SIRT-1-mediated PGC-1α expression in nonalcoholic fatty liver disease
- The effects of Formoterol in preventing adipogenesis and obesity are mediated by PPARγ/C/EBPα axis and AMPK/PGC-1α pathway
- PGC-1α: a target for neurodegenerative disorders
- Curcumin relieves CUMS-induced depressive-like behaviors through PGC-1α/FNDC5/BDNF pathway
- The effect of 8 weeks of interval and resistance training on expression PGC 1α, AMPK, TFAM Elderly rat heart cells
- Propofol ameliorates acute postoperative fatigue and promotes glucagon-regulated hepatic gluconeogenesis by activating CREB/PGC-1α and accelerating fatty acids …
- Dipeptidyl peptidase-4 involved in regulating mitochondria function in cardiomyocytes through Nrf2 and PGC-1α signaling
- Neuroscience of Disease: PV-specific loss of the transcriptional coactivator PGC-1α slows down the evolution of epileptic activity in an acute ictogenic model
- Agrimol B inhibits colon carcinoma progression by blocking mitochondrial function through the PGC-1α/NRF1/TFAM signaling pathway
- Cardiac Fibroblast-Specific Knockout of PGC-1α Accelerates AngII-Induced Cardiac Remodeling
- Twist1 downregulation of PGC-1α decreases fatty acid oxidation in tubular epithelial cells, leading to kidney fibrosis
- … of HIIT vs. CET exercise training on high-fat-high-fructose diet-induced hyperglycemia, hyperlipidemia, and histopathology of liver in rats: regulation of SIRT1/PGC-1α
- The Effect of Moderate and High Intensity Resistance Training on the Expression of PGC-1α, TFAM and AMPK of Cardiomyocytes in Elderly Rats
- Effect of lactate administration on exercise-induced PGC-1α mRNA expression in Thoroughbreds
- Maternal obesity inhibits placental angiogenesis by down-regulating the SIRT1/PGC-1α pathway
- Rhein Relieves Oxidative Stress in an Aβ Model 1-42 Oligomer-Burdened by Activating the SIRT1/Neuron PGC-1α-Regulated Mitochondrial Biogenesis
- Effect of post-exercise muscle cooling on PGC-1α and VEGF mRNA expression in Thoroughbreds
- Crocetin protects cardiomyocytes against hypoxia/reoxygenation injury by attenuating Drp1-mediated mitochondrial fission via PGC-1α
- Arsenic-Induced Mitochondria-Mediated Apoptosis is Associated with PGC-1α Decrease in Rat Brain
- Bioactives From Coffee By-Products Stimulate Liver Metabolism and Mitochondrial Bioenergetics via AMPK/PGC-1α/Nrf2 and IRS/AKT/GLUT2 Pathways In Vitro
- Investigating the impact of PGC-1α-coupled metabolic reprogramming on breast cancer metastasis
- Involvement of the SIRT1/PGC-1α signaling pathway in noise-induced hidden hearing loss
- Investigation of PGC-1α function in zebrafish
- Canagliflozin Promotes Mitochondrial Biogenesis in Glycerol-Induced Acute Kidney Injury by Activating the AMPK/SIRT1/FOXO-3a/PGC-1α and Nrf2/HO-1 …
- Canagliflozin Regulates Ferroptosis, Potentially via Activating AMPK/PGC-1α/Nrf2 Signaling in HFpEF Rats
- PGC-1α: a metabolic regulator
- Beta Caryophyllene in Combination with Dexmedetomidine Synergistically Inhibits Cell Proliferation in Ovarian Cancer: Involvement of AMPK and PGC-1α …
- PGC‐1α is downregulated in a mouse model of obstructive cholestasis but not in a model of liver fibrosis
- Shenqi Lixin Decoction improves cardiac function in rats with adriamycin-induced heart failure through modulation of PGC-1α and mitochondrial apoptosis …
- Importance of PGC-1α gene expression in Egyptian hemodialysis patients
- The neuroprotection of electro-acupuncture via the PGC-1α/TFAM pathway in transient focal cerebral ischemia rats
- Pioneering PGC-1α-Boosted Secretome: A Novel Approach to Combating Liver Fibrosis
- Pterostilbene induces browning of white adipocytes via AMPK/PGC-1α pathway
- Study on the relationship between relieving energy crisis in myofascial trigger points with An-Pressing manipulation and AMPK/PGC-1α pathway activation
- Metformin induced M2 polarization to improve peripheral nerve regeneration by regulating AMPK/PGC-1α/PPAR-γ pathway
- The impact of prolonged and intermittent fasting on PGC-1α, Oct-4 and CK-19 liver gene expression.
- Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene …
- PGC-1α Interacts with MicroRNA-217 to Functionally Regulate Breast Cancer Cell Proliferation
- A41 THE ROLE OF PGC-1α IN MURINE BONE MARROW DENDRITIC CELLS
- Isovitexin restores sevoflurane‑induced cognitive dysfunction by mediating autophagy through activation of the PGC-1α/FNDC5 signaling pathway
- Effects of eight weeks of TRX training on serum levels of PGC-1α and citrate synthase in overweight women
- Correction to Phytol Promotes the Formation of Slow-Twitch Muscle Fibers through PGC-1α/miRNA but Not Mitochondria Oxidation
- Knockdown of 11β-hydroxysteroid dehydrogenase type 1 alleviates LPS-induced myocardial dysfunction through the AMPK/SIRT1/PGC-1α pathway
- Influence of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha (PGC-1α) in Type 2 Diabetes
- Elabela-APLNR inhibits cerebral ischemia/reperfusion injury through AMPK/SIRT3/PGC-1α and Akt/Nrf2 pathways
- Cardiac Fibroblast-Specific Knockout of PGC-1α Accelerates AngII-Induced Cardiac Remodeling
- METTL3 promotes PGC-1α transcription and alleviates mitochrondrial dysfunction of diabetic nephropathy by targeting lncRNA TUG1 m6A modification
- IL-4 Mediated Upregulation of AMPK/SIRT1/PGC-1α Signalling Pathway Is Bypassed By Mitochondrial Complex I Downregulation By NAMPT Inhibition in Venetoclax …
- Peroxisome Proliferator Activated Receptor γ Coactivator-1α (PGC-1α) Activation to Enhance Macrophage Immune Function in Nontuberculous Mycobacteria (NTM) …
- Explore the role of irisin in mitohormesis by PGC-1α
- Formononetin Attenuates Renal Tubular Injury and Mitochondrial Damage in Diabetic Nephropathy Partly via Regulating Sirt1/PGC-1α Pathway
- Impact of the PGC-1α Gly482Ser Polymorphism on Mouse Metabolism
- Pathways in uremic cardiomyopathy–the intracellular orchestrator PGC-1α in cell culture and in a mouse model of uremia
- The effect of short endurance training on the expression level of PINK-1, Parkin and PGC-1α in the heart of nicotine-sensitized rats
- EFFECT OF 6 WEEKS ENDURANCE TRAINING WITH QUERCETIN SUPPLEMENTATION ON THE EXPRESSION OF MITOCHONDRIAL PGC-1α AND ATF2 GENES …
- … ) and Eubacterium rectal Supplementation on Skeletal Muscle Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) Expression in Diabetic …
- 5′-CMP and 5′-UMP promote myogenic differentiation and mitochondrial biogenesis by activating myogenin and PGC-1α in a mouse myoblast C2C12 cell …
- Association of Single Nucleotide Polymorphisms of ARL15 and PGC-1α Genes with Diabetic Kidney Disease
- Effect of Aerobic Exercise Combined With Thyme Extract Supplementation on the PGC-1α Gene Expression in Adult Male Rats
- The Effect Of Eight-Week High Intensity Interval Training (Hiit) And Caffeine Intake On The PGC-1α Expression In Soleus Muscle In Diabetic Rats Induced …
- Correlation analysis of serum CTRP3 and PGC-1α expression with traumatic fracture healing
- CircRNA_0000927 promotes inflammatory response to neuronal injury via miR-126a-5p/PGC-1α axis in acute ischemic stroke
- … associated lung cancer proliferation and tumor growth is prevented by β-caryophyllene: Role of AMPK activation and PGC-1α/TFAM over expression
- Atorvastatin Induces FXR and CYP7A1 Activation as a Result of the Sequential Action of PPARγ/PGC-1α/HNF-4α in Hep3B Cells
- Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene …
- Identifying PGC-1α-dependent hepatokines in a non-alcoholic fatty liver disease murine model
- Effect of HIIT and Q10 supplementation on soleus muscle PGC-1α level citrate synthase activity in obese male rats
- PERM1 regulates energy metabolism in the heart via ERRα/PGC− 1α axis
- Hyperbaric Oxygen Therapy Improves Parkinson’s Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway. Biomolecules 2022, 12 …
- PPARγ and PGC-1α activators protect against diabetic nephropathy by suppressing the inflammation and NF-κB activation
- PGC-1α Is Indispensable in Purple Potato Promoted Intestinal Epithelial Differentiation and Mitochondrial Biogenesis
- Nucleolin promotes autophagy through PGC-1α in LPS-induced myocardial injury.
- The alteration of PGC-1α expression in younger non-professional athletes with acute medium intensity exercise model
- New roles for PGC-1α in diet-associated liver cancer and hepatic inflammation
- The Gly482Ser Polymorphism Affects PGC-1α Stability in INS-1 β-Cells
- The effect of an aerobic exercise course on the genes expression of Sirt-1 and PGC-1α in the left ventricle of rats with type 2 diabetes
- PGC-1α As A Mechanistic Driver Of Exercise-Induced Regulation Of Intermuscular Adipose: In Silico Approach Of GSEA-Guided Network Propagation
- AB0172 PGC-1α REGULATES AUTOPHAGY TO PROMOTE FIBROBLAST ACTIVATION AND TISSUE FIBROSIS
- PGC-1α in human CD4+ T cell subsets
- Redox signaling in acute pancreatitis: roles of PGC-1α and sulfiredoxin
- The effect of high-intensity interval training (HIIT) on nesfatin, irisin and resistin and gene expression of PGC-1α in Wistar rats Mozhgan Ahmadi1
- Corrigendum to “Estrogen-related Receptor Alpha (ERRα) is Required for PGC-1α-dependent Gene Expression in the Mouse Brain”[Neuroscience 479 (2021) 70–90]
- The effect of a period of high-intensity interval training on the content of AMPK and PGC-1α proteins in the heart muscle tissue of rats with type 2 diabetes
- 75-The Gly482Ser Polymorphism Affects PGC-1α Stability and Function in INS-1 β-Cells
- Synergistic Effects of Four Weeks of Endurance Training with Probiotic Supplementation on the Expression of PGC-1α and Citrate Synthase Genes in Soleus Muscles …
- The preclinical study of the expression changes of PGC-1α and SIRT genes
- Establishment of Drug-Resistant Cell Lines of Acute Myeloid Leukemia and Correlation of Sirt1 and PGC-1α Expression Levels with Drug Resistance
- Endoplasmic reticulum stress reduces PGC-1α in skeletal muscle through ATF4 and the mTOR-CRTC2 axis
- … derivative) inhibits proliferation, suppresses cell migration and invasion and decreases tumor growth of osteosarcoma: role of PGC-1α/TFAM and AMPK …
- The Effects of Sodium Butyrate Supplementation on the Expression Levels of PGC-1α, PPARα, and UCP-1 Genes, Serum Level of GLP-1, Metabolic Parameters …
- The effect of high-intensity interval training (HIIT) on nesfatin, irisin and resistin and gene expression of PGC-1α in Wistar rats
- Correction to: Role of Estrogen-related Receptor γ and PGC-1α/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage
- Secretion Of PGC-1α By Modulating Physical Exercise To Protect Improving Obesity Prevalence
- Effect of Endurance Training and MitoQ on Expression of PGC-1α, ERR-α, MCAD, and CPT-1α Genes in Skeletal Muscle of Male Wistar Rats
- Differential role of PGC-1α isoforms in the modulation of astrocytes reactive phenotype
- The impact of aerobic training intensity on skeletal muscle PGC-1α, interferon regulatory factor 4, and atherogenic index in obese male Wistar rats.
- The effects of cold water immersion post repeated sprint activity on serum PGC-1α and irisin in young active men
- Effect of herbal cake-separated moxibustion on behavioral stress reactions and blood lactic acid level and muscular AMPK/PGC-1α signaling in rats with chronic …
- Cardioprotective effect of ivabradine via the AMPK/SIRT1/PGC-1α signaling pathway in myocardial ischemia/reperfusion injury induced in H9c2 cell
- PGC-1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI
- Hepatic PGC-1α has minor regulatory effect on the transcriptome and metabolome during high fat high fructose diet and exercise.
- … , Alone and in a Mixture, Impaired Male Fertility and Sexual Behavior in Adult Rats via Suppression of Steroidogenic Genes and SIRT1/TERT/PGC-1α Pathway
- The effect of 4 weeks aerobic swimming training and aqueous Urtica dioica extract on PGC-1α and UCP1 gene expression and serum concentrations of irisin and …
- Interaction effect of 4 weeks of endurance training and octopamine on gene expression of PGC-1α in brown adipose tissue of male rats fed with DFO
- Decreased kidney mitochondrial content and PGC-1α following repeated low-dose cisplatin-induced kidney injury.
- Effects of different types of exercise on contractile properties and expressions of MuRF1, PGC-1α/FNDC5 in soleus muscle of unloaded rats
- Effect of Sea grapes-Antioxidants Extract on Lipid Profile and PGC-1α Levels in Obese Men: 4 Weeks Randomized-Double Blind Controlled Trial
- Effect of Gualou Xiebai Banxiatang on Mitochondrial Dysfunction and AMPK/PGC-1α Signaling Pathway in Rats with Ischemic Myocardial Injury
- … on Protective Mechanism of Dracocephalum moldavica Total Flavonoids against Myocardial Ischemia-reperfusion Injury in Rats Based on AMPK/SIRT 1/PGC-1α …
- Withdrawal: Exercise increases mitochondrial PGC-1α content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis.
- PGC-1α protects a fibrotic liver from partial hepatectomy-induced advanced liver injury through regulating cell cycle arrest.
- Research Article Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts.
- Plagiarism_The Effect of Aerobic Exercise and Caloric Restriction on Mice’s Brain Tissue PGC-1α Levels and Their Memory Abilities
- Energy deprivation-induced AMPK activation inhibits milk synthesis via PrlR and PGC-1α
- PGC-1α Pathway Time Course Phosphorylation Following Endurance Exercise: A systematic
- 283 Quercetin Antagonizes Tall Fescue Toxicosis-Induced Cardiovascular Toxicity in Lamb (Ovis Aries) via Modulating PGC-1α Mediated Mitochondrial Biogenesis
- The effect of eight weeks of high intensity interval training and moderate continuous training on PGC-1α and ERRα gene expression in subcutaneous adipose …
- Oxidant-Mediated Transcription and Post-Translational Modification of PGC-1α Is Required for Fibrotic Repair
- Anti-angiogenic effects of a novel small molecular activator of PGC-1α
- RENAL DENERVATION REGULATES LIPID METABOLISM THROUGH AMPK/PGC-1α PATHWAY IN DIET-INDUCED OBESE RATS
- A histochemical double staining protocol for GABA-α2 and CAMKII in hippocampal neurons using PGC-1α transgenic mice as an example
- WCN23-1034 miR-1224 of circulating extracellular vesicles induce mitochondria-mediated podocyte injury by inhibiting CREB/PGC-1α pathway in metabolic …
- An AMP-activated protein kinase-PGC-1α axis mediates metabolic plasticity in glioblastoma
- PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis
- Erratum to” Melatonin-Induced PGC-1α Improves Angiogenic Potential of Mesenchymal Stem Cells in Hindlimb Ischemia”[Biomol. Ther. 28 (2020) 240-249]
- 2P-225: Antioxidative effect of PGC-1α-derived peptide material conjugated with gallic acid
- Retraction of “GPR40 Agonist GW9508 Ameliorates Oxidized LDL-Induced Endothelial Dysfunction via the AMPK/CREB/PGC-1α Pathway”
- Tetramethylpyrazine nitrone exerts neuroprotection via PGC-1α/Nrf2 activation and α-synuclein clearance in Parkinson’s disease models
- Improvement of liver damage by clove leaf extracts in rats with acute pancreatitis regulated by SIRT1/PGC-1α/NRF1 signaling pathway
- Study on the correlation between methylation level of PGC-1α gene and fetal distress in pregnant women with gestational diabetes mellitus
- Effect of muscle exercise on metabolic disturbance induced by ovariectomy alone or with diabetes mellitus in rats; targeting the role of PGC-1α and FNDC5 expression
- Alterations in PGC-1α and UCP1 gene expression in epicardial aadipose tissue and serum orexin-a following aerobic exercise in high-fat diet induced obesity of male …
- Abstract WP154: The Role of Ethylmethylhydroxypyridine Succinate in the Induction of PGC-1α in Experimental Ischemic Damage of the Prefrontal Cortex
- FGF21 restores hippocampual mitochondrial dysfunction via enhancing Nrf2/HO-1 and AMPK/SirT1/PGC-1α signaling pathways to alleviate chronic …
- … mitochondrial damage evoke complement component C5 activation independent of component C3 in dry age‐related macular degeneration like NFE2L2/PGC‐1α …
- Tongmai Yangxin Pills Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy
- The Effect Of Eight Weeks Of Daily Normobaric Hypoxia (60 Minutes) On PGC-1α Content Of Soleus Muscle, Insulin Resistance, And Fasting Glucose In Type 2 …
- Solid-Phase Synthesis of Modified Peptides Based on PGC-1α Alpha, a Regulator of Cellular Metabolism
- Research Article Short Alkyl Chain-Length Resorcinol Olivetol Protects Against Obesity with Mitochondrial Activation by PGC-1α Deacetylation
- Evaluation of SIRT1 and PGC-1α, gene expression in testicular tissue of azoospermic rats treated with busulfan after a period of swimming training
- Effect of Organic Selenium during HS in Broiler Chicken: The Interplay of HSP-70 and PGC-1α
- PGC-1α activity and mitochondrial dysfunction in preterm infants
- Correction to: Shen Qi Li Xin formula improves chronic heart failure through balancing mitochondrial fission and fusion via upregulation of PGC-1α
- Predictive value of serum PGC-1α mRNA and irisin levels on hemorrhagic transformation in patients with acute ischemic stroke
- SGK2 Is Elevated by the βAR-cAMP-PGC-1α Axis but Dispensable for Brown/Beige Adipose Thermogenesis
- Hyperbaric Oxygen Up-Regulates the Expression of PGC-1α to Improve Osteoporosis and Enhances the Effect of Treadmill Exercise On Osteoporosis In …
- THE EFFECT OF SIX WEEKS OF REST-PAUSE RESISTANCE TRAINING ON PGC-1α EXPRESSION IN YOUNG NON-ATHLETE MEN
- Leucine as regulator of mitochondrial biogenesis via modulating PGC-1α-targeting microRNAs in C2C12 myotubes
- AMPK/SIRT1/PGC-1α/SIRT3 pathway-independent activation of GPx1 expression by metformin in the heart of a mouse model of endometriosis
- Da Chaihutang Protects Liver Mitochondrial Function of Nutritionally Obese Rats via CREB/PGC-1α Pathway
- Enhanced Liver Regeneration of the Secretome Released from ASCs by PGC-1α-Driven Upregulation of Mitochondrial Proliferation
- Protein Kinase SGK2 Is Induced by the β3 Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue …
- Tangshen formula improves cholesterol uptake and efflux of macrophages induced by high lipid via activating PGC-1α/LXR/ABCA1 pathway
- Human dental pulp stem cells conditioned medium protects genioglossus myoblast from cobalt chloride-induced hypoxia injury through AMPK/PGC-1α pathway
- Melatonin Potentiates Exercise-Induced Increases in Skeletal Muscle PGC-1α and Optimizes Glycogen Replenishment
- Mulberry Leaf Flavonoids Ameliorate Obesity and Promote Adipose Tissue Browning Through Regulating AMPK/SIRT1/PGC-1α Signaling Pathway
- Enhanced hippocampal neurogenesis mediated by PGC-1α-activated OXPHOS after neonatal low-dose Propofol exposure
- Twist1 downregulation of PGC-1α decreases fatty acid oxidation in tubular epithelial cells, leading to kidney fibrosis: Erratum
- Corrigendum to’Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions'[Brain …
- … Glycolysis of HL-60 Cells by Modulating Sirtuin 1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α)/Hypoxia-Inducible Factor-2α …
- Retraction Note to: MiR-138-5p exacerbates hypoxia/reperfusion-induced heart injury through the inactivation of SIRT1-PGC-1α.
- Effects of quercetin on hepatic fibroblast growth factor-21 (FGF-21) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) levels in rats …
- … against high fat diet-induced obesity cardiomyopathy and defective autophagy: role of CaM kinase II, histone H3K9 methyltransferase SUV39H, Sirt1, and PGC-1α …
- … /δ preserves mitochondrial respiratory function after ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling
