BECLIN-1 & AUTOPHAGY
January 22, 2020PRISTIMERIN
January 22, 2020
- A cell-permeable STAT3 SH2 domain mimetic inhibitor of STAT3 activation inhibits growth of human breast tumor xenografts
- A cell-permeable STAT3 SH2 domain mimetic inhibits STAT3 activation and induces antitumor cell effects in vitro
- A low-molecular-weight compound discovered through virtual database screening inhibits STAT3 function in breast cancer cells
- A membrane penetrating peptide aptamer inhibits STAT3 function and suppresses the growth of STAT3 addicted tumor cells
- A millet bran-derived peroxidase inhibits cell migration by antagonizing STAT3-mediated epithelial-mesenchymal transition in human colon cancer
- A natural compound derivative P-13 inhibits STAT3 signaling by covalently inhibiting Janus kinase 2
- A novel curcumin analog inhibits canonical and non-canonical functions of telomerase through STAT3 and NF-κB inactivation in colorectal cancer cells
- A novel imidazole derivate inhibits STAT3 activation via induction of SHP-1 hepatocellular carcinoma
- A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity
- A novel platinum compound inhibits constitutive STAT3 signaling and induces cell cycle arrest and apoptosis of malignant cells
- A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells
- A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells
- A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells
- A novel small molecule, LLL12, inhibits IL-6 induced STAT3 phosphorylation and nuclear translocation
- A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells
- A novel small molecule, LY5, selectively inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in cancer cells.
- A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling …
- A phosphopeptide mimetic prodrug targeting the SH2 domain of STAT3 inhibits tumor growth and angiogenesis
- A serine protease extracted from Trichosanthes kirilowii inhibits epithelial-mesenchymal transition via antagonizing PKM2-mediated STAT3/Snail1 pathway in human …
- A small molecule compound targeting STAT3 DNA-binding domain inhibits cancer cell proliferation, migration, and invasion
- A small molecule, LLL12 inhibits constitutive STAT3 and IL‐6‐induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma …
- Abstract B95: A novel small molecule, LLL12 inhibits STAT3 phosphorylation and activities and exhibits potent growth suppressive activity in human hepatocellular …
- Abstract P6-14-13: A Flavone from Traditional East Asian Natural Extract Inhibits STAT3 and Tumor Growth in a Syngeneic Mouse Breast Cancer Model
- Abstract# 3693: Sorafenib inhibits STAT3-regulated expression of prosurvival Mcl-1 and Bcl-xL proteins to enhance TRAIL-mediated apoptosis in human pancreatic …
- Abstract# 5627: Sorafenib inhibits STAT3 signaling, cell proliferation and survival of human glioblastomas
- Allicin Inhibits Proliferation and Invasion in Vitro and in Vivo via SHP-1-Mediated STAT3 Signaling in Cholangiocarcinoma
- An ethanolic extract of ampelopsis radix exerts anti-colorectal cancer effects and potently inhibits STAT3 signaling in vitro
- APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1–STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival
- Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells
- Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity
- Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy
- Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3
- Baohuoside I Inhibits Benzo (a) Pyrene-Induced Metastasis in A549 Lung Cancer Cells by Modulating STAT3 and EMT
- Bear Bile Powder Inhibits Growth of Hepatocellular Carcinoma via Suppressing STAT3 Signaling Pathway in Mice
- Berberine downregulates CDC6 and inhibits proliferation via targeting JAK-STAT3 signaling in keratinocytes
- Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells
- Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice …
- Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells
- Butoxy Mansonone G Inhibits STAT3 and Akt Signaling Pathways in Non-Small Cell Lung Cancers: Combined Experimental and Theoretical Investigations
- Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases
- Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer
- Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells
- Carnosol, a natural polyphenol, inhibits migration, metastasis and tumor growth of breast cancer via a ROS-dependent proteasome degradation of STAT3
- CD45 phosphatase inhibits STAT3 transcription factor activity in myeloid cells and promotes tumor-associated macrophage differentiation
- CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and STAT3 phosphorylation in multi-drug resistant ovarian cancer cells
- Celastrol inhibits proliferation and induces chemosensitization through down‐regulation of NF‐κB and STAT3 regulated gene products in multiple myeloma cells
- Celecoxib inhibits interleukin-6/Interleukin-6 receptor–induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells
- Celecoxib inhibits STAT3 phosphorylation and suppresses cell migration and colony forming ability in rhabdomyosarcoma cells
- Chalcone inhibits the activation of NF-κB and STAT3 in endothelial cells via endogenous electrophile
- Chikusetsusaponin IVa butyl ester (CS-IVa-Be), a novel IL6R antagonist, inhibits IL6/STAT3 signaling pathway and induces cancer cell apoptosis
- Chrysin induces cell growth arrest, apoptosis, and ER stress and inhibits the activation of STAT3 through the generation of ROS in bladder cancer cells
- Chrysin inhibits sphere formation in SMMC-7721 cells via modulation of SHP-1/STAT3 signaling pathway
- Constitutive activation of a slowly migrating isoform of STAT3 in mycosis fungoides: tyrphostin AG490 inhibits STAT3 activation and growth of mycosis fungoides tumor …
- Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic …
- Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell
- Costunolide inhibits osteosarcoma growth and metastasis via suppressing STAT3 signal pathway
- Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells
- Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation
- Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation
- Cryptotanshinone Inhibits STAT3 Signaling to Alleviate Cardiac Fibrosis in Type 1‐like Diabetic Rats
- Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562
- Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2–STAT3 signaling pathway
- Cucurbitacin I inhibits STAT3 and induces apoptosis in Sezary cells
- Cucurbitacin I inhibits STAT3, but enhances STAT1 signaling in human cancer cells in vitro through disrupting actin filaments
- Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells
- Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas
- Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expression
- Curcumin inhibits cystogenesis in autosomal dominant polycystic kidney disease cells via altering JAK2/STAT3 activity
- Curcumin inhibits STAT3 signaling in the colon of dextran sulfate sodium-treated mice
- CYTL1 inhibits tumor metastasis with decreasing STAT3 phosphorylation
- Debio 0617B inhibits growth of STAT3-driven solid tumors through combined inhibition of JAK, SRC, and class III/V receptor tyrosine kinases
- Differentiation-inducing factor-1 (DIF-1) inhibits STAT3 activity involved in gastric cancer cell proliferation via MEK-ERK-dependent pathway
- Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway
- Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma …
- Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor
- Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and …
- Docosahexaenoic Acid Inhibits Helicobacter pylori-induced STAT3 Phosphorylation through Activation of PPARγ.
- Docosahexaenoic acid inhibits Helicobacter pylori‐induced STAT3 phosphorylation through activation of PPARγ
- Dominant negative STAT3 mutant inhibits interleukin-6-induced Jak-STAT signal transduction
- Down-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth
- EF24 Suppresses Cholangiocellular Carcinoma Progression, Inhibits STAT3 Phosphorylation, and Induces Apoptosis via ROS-Mediated Oxidative Stress
- Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation
- Epigenomic characterization of a p53-regulated 3p22. 2 tumor suppressor that inhibits STAT3 phosphorylation via protein docking and is frequently …
- Eriocalyxin B inhibits STAT3 signaling by covalently targeting STAT3 and blocking phosphorylation and activation of STAT3
- Esculetin Inhibits Proliferation, Invasion, and Migration of Laryngeal Cancer In Vitro and In Vivo by Inhibiting Janus Kinas (JAK)-Signal Transducer and …
- Ethanol rapidly inhibits IL‐6‐activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes
- Eupatilin inhibits gastric cancer cell growth by blocking STAT3-mediated VEGF expression
- Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells
- FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
- FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling
- Functional graphene oxide as a plasmid-based STAT3 siRNA carrier inhibits mouse malignant melanoma growth in vivo
- Gambogic acid inhibits STAT3 phosphorylation through activation of protein tyrosine phosphatase SHP-1: potential role in proliferation and apoptosis
- Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway
- Geranylnaringenin (CG902) inhibits constitutive and inducible STAT3 activation through the activation of SHP-2 tyrosine phosphatase
- Ginsenoside 20 (S)‑Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells
- GRIM-19 inhibits the STAT3 signaling pathway and sensitizes gastric cancer cells to radiation
- Hepatocyte IKKβ/NF-κB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation
- Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells
- Honokiol eliminates glioma/glioblastoma stem cell-like cells via JAK-STAT3 signaling and inhibits tumor progression by targeting epidermal growth factor …
- Honokiol inhibits constitutive and inducible STAT3 signaling via PU. 1-induced SHP1 expression in acute myeloid leukemia cells
- Honokiol inhibits lung cancer brain metastasis through inhibition of STAT3 signaling pathway
- I157172, a novel inhibitor of cystathionine γ-lyase, inhibits growth and migration of breast cancer cells via SIRT1-mediated deacetylation of STAT3
- Icaritin inhibits JAK/STAT3 signaling and growth of renal cell carcinoma
- IFN-λ inhibits miR-122 transcription through a STAT3-HNF4α inflammatory feedback loop in an IFN-α resistant HCV cell culture system
- IFNγ-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells
- IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals
- IL-32θ inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer
- IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-induced STAT3 phosphorylation in human hepatocellular cancer cells
- Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway
- Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity
- Interleukin 37 expression inhibits STAT3 to suppress the proliferation and invasion of human cervical cancer cells
- Isoharringtonine inhibits breast cancer stem-like properties and STAT3 signaling
- Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway
- Janus kinase 2 inhibitor AG490 inhibits the STAT3 signaling pathway by suppressing protein translation of gp130
- Kaempferia parviflora Extract Inhibits STAT3 Activation and Interleukin-6 Production in HeLa Cervical Cancer Cells
- Knockdown of STAT3 expression by RNA interference inhibits the induction of breast tumors in immunocompetent mice
- Let-7a Inhibits T-Cell Proliferation and IFN-γ Secretion by Down-Regulating STAT3 Expression in Patients with Psoriasis
- LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
- LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells
- Long non-coding RNA TPTEP1 inhibits hepatocellular carcinoma progression by suppressing STAT3 phosphorylation
- LRIG1 inhibits STAT3-dependent inflammation to maintain corneal homeostasis
- LTP-1, a novel antimitotic agent and STAT3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo
- Lumbar puncture-administered resveratrol inhibits STAT3 activation, enhancing autophagy and apoptosis in orthotopic rat glioblastomas
- Lycorine inhibits the growth and metastasis of breast cancer through the blockage of STAT3 signaling pathway
- LYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression
- Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation
- Metastasis suppressor Nm23-H1 inhibits STAT3 signaling via a negative feedback mechanism
- Methyllucidone inhibits STAT3 activity by regulating the expression of the protein tyrosine phosphatase MEG2 in DU145 prostate carcinoma cells
- Micheliolide inhibits gastric cancer growth in vitro and in vivo via blockade of the IL-6/STAT3 pathway
- MicroRNA in vivo precipitation identifies miR-151-3p as a computational unpredictable miRNA to target STAT3 and inhibits innate IL-6 production
- miR-1181 inhibits invasion and proliferation via STAT3 in pancreatic cancer
- miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of
- MiR-124 inhibits STAT3 signaling to enhance T cell–mediated immune clearance of glioma
- Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1
- Natural product pectolinarigenin inhibits osteosarcoma growth and metastasis via SHP-1-mediated STAT3 signaling inhibition
- Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway
- Niclosamide Inhibits Cell Growth and Enhances Drug Sensitivity of Hepatocellular Carcinoma Cells via STAT3 Signaling Pathway
- Nimbolide-induced oxidative stress abrogates STAT3 signaling cascade and inhibits tumor growth in transgenic adenocarcinoma of mouse prostate model
- Nobiletin inhibits angiogenesis by regulating Src/FAK/STAT3-mediated signaling through PXN in ER+ breast cancer cells
- Novel Carbazole Inhibits Phospho-STAT3 through Induction of Protein–Tyrosine Phosphatase PTPN6
- Novel small molecule, XZH‐5, inhibits constitutive and interleukin‐6‐induced STAT3 phosphorylation in human rhabdomyosarcoma cells
- Nuclear protein IκB-ζ inhibits the activity of STAT3
- Obatoclax analog SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells
- Obatoclax analogue SC-2001 inhibits STAT3 phosphorylation by enhancing protein tyrosine phosphatase SHP-1 expression and induces apoptosis in human breast …
- Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3
- Osthole inhibits triple negative breast cancer cells by suppressing STAT3
- Overexpressed HO-1 is associated with reduced STAT3 activation in preeclampsia placenta and inhibits STAT3 phosphorylation in placental JEG-3 cells …
- p14 ARF inhibits the growth of lung adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling …
- Paeoniflorin inhibits human glioma cells via STAT3 degradation by the ubiquitin–proteasome pathway
- Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity
- Parthenolide inhibits STAT3 signaling by covalently targeting Janus kinases
- PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3
- Penta-1, 2, 3, 4, 6-O-galloyl-β-d-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo
- Pentagalloylglucose inhibits the replication of rabies virus via mediating the miR-455/SOCS3/STAT3/IL-6 pathway
- Pentoxifylline inhibits melanoma tumor growth and angiogenesis by targeting STAT3 signaling pathway
- Periplocin of cortex periplocae inhibits STAT3 signaling and induces apoptosis in human hepatocellular carcinoma cell line SMMC-7721
- Phenethyl isothiocyanate inhibits STAT3 activation in prostate cancer cells
- Piperine inhibits IL-1β-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells
- Piperlongumine derivative, CG-06, inhibits STAT3 activity by direct binding to STAT3 and regulating the reactive oxygen species in DU145 prostate carcinoma cells
- Platelet factor 4 inhibits IL-17/STAT3 pathway via upregulation of SOCS3 expression in melanoma
- Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCε, STAT3 and neuroendocrine markers
- Plumbagin inhibits prostate carcinogenesis in intact and castrated PTEN knockout mice via targeting PKCε, STAT3, and epithelial-to-mesenchymal transition markers
- Plumericin inhibits proliferation of vascular smooth muscle cells by blocking STAT3 signaling via S-glutathionylation
- Ponatinib inhibits STAT3 activity and reduces colorectal cancer growth
- Prolonged insulin treatment inhibits GH signaling via STAT3 and STAT1
- Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells
- Proscillaridin A promotes oxidative stress and ER stress, inhibits STAT3 activation, and induces apoptosis in A549 lung adenocarcinoma cells
- Protopanaxadiol inhibits epithelial–mesenchymal transition of hepatocellular carcinoma by targeting STAT3 pathway
- PTPMeg2 inhibits STAT3 transcriptional activity in NIH3 T3/STAT3 CA cell model
- Puupehenol natural product inhibits STAT3 signaling and induces antitumor cell effects in vitro against human glioblastoma cells
- Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes
- Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3
- Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration
- Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling
- Resveratrol inhibits hypoxia-induced glioma cell migration and invasion by the p-STAT3/miR-34a axis
- Resveratrol inhibits Src and STAT3 signaling and induces the apoptosis of malignant cells containing activated STAT3 protein
- Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells
- RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells
- RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation
- RNA interference targeting STAT3 inhibits growth and induces apoptosis of human prostate cancer cells
- RNAi-mediated silencing of Anxa2 inhibits breast cancer cell proliferation by downregulating cyclin D1 in STAT3-dependent pathway
- S3I-201, a novel STAT3 inhibitor, inhibits growth of human soft tissue sarcoma cell lines
- Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
- Saw palmetto extract inhibits metastasis and antiangiogenesis through STAT3 signal pathway in glioma cell
- Scavenging reactive oxygen species selectively inhibits M2 macrophage polarization and their pro-tumorigenic function in part, via STAT3 suppression
- Silibinin inhibits constitutive activation of STAT3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells
- SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma
- Sorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3
- Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells
- SR16388 inhibits STAT3 activation and angiogenesis in lung cancer model
- STAT1 inhibits STAT3 activation in esophageal squamous cell carcinoma
- STAT3 oligonucleotide inhibits tumor angiogenesis in preclinical models of squamous cell carcinoma
- STAT3 silencing with lentivirus inhibits growth and induces apoptosis and differentiation of U251 cells
- STAT3/STAT5 blockade by WP1066 inhibits ovarian cancer cell proliferation and induces cell death
- Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways
- Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells
- Sulphoraphane inhibits STAT3 and its related genes in Du 145 cancer cells
- Systemic administration of a cyclic signal transducer and activator of transcription 3 (STAT3) decoy oligonucleotide inhibits tumor growth without inducing …
- Tanshinone I inhibits tumor angiogenesis by reducing STAT3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and …
- Tanshinone IIA inhibits cell proliferation and tumor growth by downregulating STAT3 in human gastric cancer
- Tanshinone IIA inhibits epithelial-mesenchymal transition in bladder cancer cells via modulation of STAT3-CCL2 signaling
- Targeted blockade of JAK/STAT3 signaling inhibits ovarian carcinoma growth
- Targeted Disruption of STAT3 Signaling Inhibits Tumor Growth and Brain Metastases by Caveolin-1 Upregulation
- Targeting mitochondrial STAT3 with the novel phospho-valproic acid (MDC-1112) inhibits pancreatic cancer growth in mice
- Targeting STAT3 inhibits growth and enhances radiosensitivity in head and neck squamous cell carcinoma
- The Antioxidant Alpha-Lipoic Acid Inhibits Proliferation and Invasion of Human Gastric Cancer Cells via Suppression of STAT3-Mediated MUC4 Gene Expression
- The fruits of Gleditsia sinensis Lam. inhibits adipogenesis through modulation of mitotic clonal expansion and STAT3 activation in 3T3-L1 cells
- The histone deacetylase inhibitor valproic acid inhibits NKG2D expression in natural killer cells through suppression of STAT3 and HDAC3
- The Interaction of Specific Peptide Aptamers With the DNA Binding Domain and the Dimerization Domain of the Transcription Factor STAT3 Inhibits Transactivation and …
- The intracellular delivery of a recombinant peptide derived from the acidic domain of PIAS3 inhibits STAT3 transactivation and induces tumor cell death
- The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway
- The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with …
- The knock-down of Caveolin-1 inhibits STAT3 signaling in human metastatic lung cancer in vitro
- The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 …
- THE PHARMACOLOGICAL IGF1R-IRS1/2 INHIBITOR OSI-906 REDUCES ERYTHROID PROGENITORS AND INHIBITS STAT3 IN JAK2V617F KNOCKIN …
- The rabies virus interferon antagonist P protein interacts with activated STAT3 and inhibits Gp130 receptor signaling
- The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6 receptor in diffuse large B-cell lymphoma
- The S52F FOXF1 mutation inhibits STAT3 signaling and causes alveolar capillary dysplasia
- The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells
- The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice
- The tumor suppressor miR-124 inhibits cell proliferation by targeting STAT3 and functions as a prognostic marker for postoperative NSCLC patients
- Therapeutic ablation of gain-of-function mutant p53 in colorectal cancer inhibits STAT3-mediated tumor growth and invasion
- Therapeutic targeting of STAT3 (signal transducers and activators of transcription 3) pathway inhibits experimental autoimmune uveitis
- Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro
- TIS21/BTG2/PC3 inhibits interleukin-6 expression via downregulation of STAT3 pathway
- Tocilizumab inhibits neuronal cell apoptosis and activates STAT3 in cerebral infarction rat model
- Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)→ signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition …
- Ultrasound targeted microbubble destruction-mediated delivery of a transcription factor decoy inhibits STAT3 signaling and tumor growth
- Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells
- Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells
- Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3
- Withacnistin inhibits recruitment of STAT3 and STAT5 to growth factor and cytokine receptors and induces regression of breast tumours
- Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells
- Withaferin A inhibits STAT3 and induces tumor cell death in neuroblastoma and multiple myeloma
- Withaferin-A inhibits colon cancer cell growth by blocking STAT3 transcriptional activity
- WP1130, a small molecular weight compound, inhibits JAK2-STAT3 signaling through a unique degradation mechansim
- Xanthatin inhibits STAT3 and NF‐κB signalling by covalently binding to JAK and IKK kinases
- Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells
- XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells
- XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells
- YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells
- YY1 inhibits the migration and invasion of pancreatic ductal adenocarcinoma by downregulating the FER/STAT3/MMP2 signaling pathway
- Zerumbone inhibits growth of hormone refractory prostate cancer cells by inhibiting JAK2/STAT3 pathway and increases paclitaxel sensitivity
- β‐caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP‐1 protein tyrosine phosphatase
- (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via STAT3 in gastric cancer
- (-)-Oleocanthal exerts anti-melanoma activities and inhibits STAT3 signaling pathway
- (−)-Oleocanthal inhibits growth and metastasis by blocking activation of STAT3 in human hepatocellular carcinoma
- 15-Keto prostaglandin E2 inhibits STAT3 signaling in H-Ras transformed mammary epithelial cells
- 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression
- 19-nor-1α-25-dihydroxyvitamin D2 induces gastric cancer cell apoptosis and cell cycle arrest and inhibits STAT3 mediated inflammation
- 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells …
- 2-Pyridyl Cyclohexanone Inhibits Activated STAT3 and Promotes Apoptosis of Human Esophageal Squamous Cell Carcinoma Cells
- 2′-Hydroxyflavanone inhibits prostate tumor growth through inactivation of AKT/STAT3 signaling and induction of cell apoptosis
- 3-Deoxy-2β, 16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the …
- 6-Bromoindirubin-3′-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells
- 782 SANGUINARINE INHIBITS STAT3 ACTIVATION AND TUMOR GROWTH IN PROSTATE CANCER CELLS
