Phosphatidylinositol 3‐kinase Activation of Phosphatidylinositol 3-kinase by insulin. The activation of Phosphatidylinositol 3-kinase by Ras Association of focal adhesion kinase with its potential substrate Phosphatidylinositol 3-kinase. Phosphatidylinositol 3-kinase related kinases Phosphatidylinositol 3-kinase Encoded by Yeast VPS34 Gene Essential for Protein Sorting Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit Wortmannin is a potent Phosphatidylinositol 3-kinase inhibitor: the role of Phosphatidylinositol 3, 4, 5-trisphosphate in neutrophil responses Requirement for Phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor Ras-dependent induction of cellular responses by constitutively active Phosphatidylinositol-3 kinase Activation of Phosphatidylinositol-3′ kinase by Src-family kinase SH3 binding to the p85 subunit Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation. A human Phosphatidylinositol 3‐kinase complex related to the yeast Vps34p‐Vps15p protein sorting system. Wortmannin, a potent and selective inhibitor of Phosphatidylinositol-3-kinase A specific inhibitor of Phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated Phosphatidylinositol 3-kinase Membrane localization of Phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways The Phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors. Cloning of a novel, ubiquitously expressed human Phosphatidylinositol 3-kinase and identification of its binding site on p85 Inhibition of Phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells. Phosphatidylinositol 3'kinase: one of the effectors of Ras Association of p21ras with Phosphatidylinositol 3-kinase. Interaction of Phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors ErbB3 is involved in activation of Phosphatidylinositol 3-kinase by epidermal growth factor Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells Activation of the Eck receptor protein tyrosine kinase stimulates Phosphatidylinositol 3-kinase activity. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation The inhibition of Phosphatidylinositol 3-kinase by quercetin and analogs Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells Studies on the mechanism of Phosphatidylinositol 3-kinase inhibition by wortmannin and related analogs CD19 of B cells as a surrogate kinase insert region to bind Phosphatidylinositol 3-kinase DNA-dependent protein kinase catalytic subunit: a relative of Phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product Involvement of Phosphatidylinositol 3-kinase in Fc gamma receptor signaling. The interaction of small domains between the subunits of Phosphatidylinositol 3-kinase determines enzyme activity Interkinase domain of kit contains the binding site for Phosphatidylinositol 3'kinase. Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, Phosphatidylinositol 3'-kinase, and protein kinase C. Mouse p170 is a novel Phosphatidylinositol 3-kinase containing a C2 domain Inhibition of the Phosphatidylinositol 3-kinase/p70S6-kinase pathway induces B16 melanoma cell differentiation Epidermal growth factor-dependent association of Phosphatidylinositol 3-kinase with the erbB3 gene product. The structure and function of p55PIK reveal a new regulatory subunit for Phosphatidylinositol 3-kinase Phosphatidylinositol 3-kinase and its novel product, Phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae Phosphatidylinositol 3-kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein kinase Signaling Pathway (∗) Phosphatidylinositol (3, 4, 5)
Reversal of Obesity by targeted ablation of adipose tissue Reversal of Obesity- and Diet-induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ Reversal of Obesity-related hypoadiponectinemia by lifestyle intervention: a controlled, randomized study in obese adolescents prevention and Reversal of Obesity and glucose intolerance in mice by DHA derivatives Reversal of Obesity-driven aggressiveness of endometrial cancer by metformin Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced Reversal of Obesity and diabetes in Zucker fa/fa rats Pilot randomized trial demonstrating Reversal of Obesity-related abnormalities in reward system responsivity to food cues with a behavioral intervention Leptin Activation of Corticosterone Production in Hepatocytes May Contribute to the Reversal of Obesity and Hyperglycemia in Leptin-Deficient ob/ob Mice Reversal of Obesity and insulin resistance by a non-peptidic glucagon-like peptide-1 receptor agonist in Diet-induced obese mice Reversal of Obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPARα, SCD1, and osteopontin Reversal of Obesity-induced hypertriglyceridemia by (R)-α-lipoic acid in ZDF (fa/fa) rats Partial Reversal of Obesity-induced insulin resistance owing to anti-inflammatory immunomodulatory potential of flaxseed oil Brown adipose tissue thermogenesis in the resistance to and Reversal of Obesity: a potential new mechanism contributing to the metabolic benefits of proglucagon … Reversal of Diet-induced Obesity and diabetes in C57BL/6J mice Association of a Self-Paid Medically Supervised Weight Management Program with Reversal of Obesity-Associated Impaired Fasting Glucose Reversal of Obesity in the genetically obese fa/fa Zucker rat with an ephedrine/methylxanthines thermogenic mixture Hypertrophy of brown adipocytes in brown and white adipose tissues and Reversal of Diet-induced Obesity in rats treated with a β3-adrenoceptor agonist Reversal of Obesity development in Ceacam1−/− male mice by bone marrow transplantation or introduction of the human CEACAM1 gene Reversal of Obesity-and Diet-induced Insulin Resistance with Salicylates or Targeted Disruption.... White adipocyte-targeted dual gene silencing of FABP4/5 for anti-Obesity, anti-inflammation and Reversal of insulin resistance: efficacy and comparison of … Reversal of Obesity: The quest for the optimum Dietary regimen Adipose tissue supports normalization of macrophage and liver lipid handling in Obesity Reversal Reversal of Obesity and metabolic disorders by exercise in high-fat Diet-induced obese c57bl/6 mice Myocardial fatty acid oxidation rates remain elevated in ob/ob mice despite Reversal of Obesity and diabetes by caloric restriction Reversal of high fat Diet-induced Obesity improves glucose tolerance, inflammatory response, β-amyloid accumulation and cognitive decline in the APP/PSEN1 mouse … Reversal of Obesity-driven aggressiveness of endometrial cancer by metformin SUN-543 Real World Evidence of Successful Weight Management for the Obese Population: Complete Reversal of Obesity Related Metabolic Co-Morbidities … Simvastatin has anti-tumorigenic effects in endometrial cancer via Reversal of Obesity-driven upregulation of lipid biosynthesis Attenuation of Obesity, Hepatic Steatosis and Reversal of Atherosclerosis by the Flavonoids Naringenin and Nobiletin The role of beta3-adrenergic receptors in control of brown and white adipose tissues and of energy balance: Reversal of Obesity by CL 316,243, a new beta3 … Atrial fibrillation and Obesity: characterization of electro-structural atrial substrate with sustained Obesity and Reversal upon weight reduction.
Inhibition of advanced glycation end products by red grape skin extract and its antioxidant activity Extract of Cassiae semen attenuates diabetic nephropathy via Inhibition of advanced glycation end products accumulation in streptozotocin-induced diabetic rats The extract of Litsea japonica reduced the development of diabetic nephropathy via the Inhibition of advanced glycation end products accumulation in db/db … Inhibition of advanced glycation end products formation by Mangifera indica leaf extract Inhibition of advanced glycation end-product Formation and Antioxidant Activity by Extracts and Polyphenols from Scutellaria alpina L. and S. altissima L. Inhibitors of aldose reductase and advanced glycation end-products formation from the leaves of Stelechocarpus cauliflorus RE Fr. The mechanisms of Inhibition of advanced glycation end products formation through polyphenols in hyperglycemic condition Litsea japonica extract inhibits neuronal apoptosis and the accumulation of advanced glycation end products in the diabetic mouse retina Nephroprotective effect of Paeonia emodi via Inhibition of advanced glycation end products and oxidative stress in streptozotocin–nicotinamide induced … Renoprotective effect of Bacopa monnieri via Inhibition of advanced glycation end products and oxidative stress in STZ-nicotinamide-induced diabetic nephropathy The Inhibition of advanced glycation end-products by five fractions and three main flavonoids from Camellia nitidissima Chi flowers Naphthopyrone glucosides from the seeds ofCassia tora with inhibitory activity on advanced glycation end products (AGEs) formation Dillenia indica L. attenuates diabetic nephropathy via Inhibition of advanced glycation end products accumulation in STZ-nicotinamide induced diabetic rats Anti-advanced glycation end-product and free radical scavenging activity of plants from the Yucatecan flora Health Promoting Effect of Phyllanthus emblica and Azadiractha indica against advanced glycation end products Formation … for in vitro modulation of aldose reductase, sorbitol accumulation and advanced glycation end products by flavonoid rich extract of Coriandrum sativum L … Potential role of Tribulus terrestris fruit extract in Inhibition of advanced glycation end products Puerariafuran, a new inhibitor of advanced glycation end products (AGEs) isolated from the roots of Pueraria lobata Potential dual role of eugenol in inhibiting advanced glycation end products in diabetes: proteomic and mechanistic insights Chemo-biological evaluation of antidiabetic activity of Mentha arvensis L. and its role in Inhibition of advanced glycation end products Osteomeles schwerinae extracts inhibits the binding to receptors of advanced glycation end products and TGF-β1 expression in mesangial cells under diabetic … A review on mechanism of Inhibition of advanced glycation end products formation by plant derived polyphenolic compounds Flavonoids and proanthocyanidins-rich fractions from Eugenia dysenterica fruits and leaves inhibit the formation of advanced glycation end-products and the activities … In vitro inhibitory activity of Acca sellowiana fruit extract on end products of advanced glycation Inhibition of highland barley bran-derived carbon dots on the formation of advanced glycation end products Effect of Italian Sour Cherry (Prunus cerasus L.) on the Formation of advanced glycation end products and Lipid Peroxidation New Pregnane Glycosides Isolated from Caralluma hexagona Lavranos as Inhibitors of α-Glucosidase, Pancreatic Lipase, and advanced glycation end products … Inhibition of protein glycoxidation and advanced glycation end-product formation by barnyard millet (Echinochloa frumentacea) phenolics … -induced atherosclerosis
… binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells … cells at the level of the blood‐testis barrier: Evidence for formation and resorption of Sertoli‐Sertoli tubulobulbar complexes during the spermatogenic cycle of the rat … cells in the peritoneal cavity of mice: influence of microphthalmia transcription factor through transcription of newly found mast cell adhesion molecule, spermatogenic … … cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells … combination of Semen Cuscutae and Fructus Lycii improves testicular cell proliferation and inhibits their apoptosis in rats with spermatogenic dysfunction by regulating … … Cryopreserved Testicular Sperm upon Intracytoplasmic Sperm Injection Pregnancy Outcomes in Men with Azoospermia due to spermatogenic Dysfunction: A Meta … … Effect of Ethanol extract of Piper nigrum L. Fruit on Reproductive System in Adult Male Wistar Rats: A Study of FSH, LH, Testosterone Level and spermatogenic … … Effects of Different Levels of Dietary Green Tea (Camellia sinensis) extract on Sperm Quality Parameters of Rooster in the Duration of an Entire spermatogenesis … … EFFECTS OF PORTULACA OLERACEA SEED extract ON LEVEL OF MALONE DIALDEHYDE IN THE TESTIS AND spermatogenesis IN DIABETIC RATS … extract of Bacopa monnieri (CDRI-08): Effect on germ cell dynamics and possible mechanisms of its beneficial action on spermatogenesis and sperm quality in male … … genes that were used in 12 patients who were negative to a diagnostic genetic test for male infertility disorders, including primary spermatogenic failure and central … … gonadotrophins, testosterone, androstenedione, estradiol, and the sex-hormone-binding globulin during stimulation with clomiphene in subjects with spermatogenic … … human spermatogenic cells dispersed in wet preparation for testicular sperm extraction: establishment of a microscopic diagram of developing human spermatogenic … … impairs testicular functions in the American oyster, Crassostrea virginica: Molecular mechanisms and induction of oxidative stress and apoptosis in spermatogenic … … mammalian sperm factor protein that triggers Ca2+ oscillations in eggs: Evidence for expression of mRNA(s) coding for sperm factor protein(s) in spermatogenic cells … Not be, Based Merely on Sperm Concentration: Shared Decision-Making and Reconsideration of Thresholds for Genetic Testing of Men with Severe spermatogenic … … of a tracing technique for transplanted bluefin tuna germ cells in recipient's gonads using monoclonal antibodies specifically recognizing bluefin tuna spermatogenic … … of both stem cell factor and clusterin mRNA levels in testicular biopsies of azoospermic patients with constitutive or idiopathic but not acquired spermatogenic failure … of CYTB-positive mitochondrial substance occurs by destructive and nondestructive mitochondrial effusion, respectively, in early and late spermatogenic cells of the … … of Normal Sperm Parameters with Medical Testicular Stimulation and Repeat Vasovasostomy in the Patient Showing spermatogenic Arrest Following Vasovasostomy … OF RASPBERRY FRUIT extract (RUBUS FRUTICOSUS L.) ON CHANGES IN GONADOTROPIN HORMONES, TESTOSTERONE AND spermatogenesis IN … … of rat testis galactosyl receptor using antibodies to liver asialoglycoprotein receptor: purification and localization on surfaces of spermatogenic cells and sperm.
DLBS1033, a protein extract from Lumbricus rubellus, possesses Antithrombotic and Thrombolytic activities … Applications ofChasmanthera dependens stem extract mediated silver nanoparticles as Antimicrobial, Antioxidant, Anticoagulant, Thrombolytic, and Larvicidal agents Screening of Thrombolytic Activity of ougainville aglabra Leaves Extract by In-Vitro In vitro antioxidant, cytotoxic, Thrombolytic activities and phytochemical evaluation of methanol extract of the A. philippense L. leaves Determination of the Thrombolytic activity of Natto extract … vivo analgesic, antipyretic, and anti-inflammatory potential in Swiss albino mice and in vitro Thrombolytic activity of hydroalcoholic extract from Litsea glutinosa … Anti-candida, anti-coagulant and Thrombolytic activities of biosynthesized silver nanoparticles using cell-free extract of Bacillus safensis LAU 13 Antidepressant, anxiolytic, antipyretic, and Thrombolytic profiling of methanol extract of the aerial part of Piper nigrum: In vivo, in vitro, and in silico approaches Phytochemical screening, Antioxidant, Thrombolytic, alpha-amylase inhibition and cytotoxic activities of ethanol extract of Steudnera colocasiifolia K. Koch leaves Stem extract of Albizia richardiana exhibits potent antioxidant, cytotoxic, antimicrobial, anti-inflammatory and Thrombolytic effects through in vitro approach Anti-inflammatory, Thrombolytic and hair-growth promoting activity of the n-hexane fraction of the methanol extract of Leea indica leaves In-vitro Thrombolytic and anti-inflammatory activity of Swertia chirata ethanolic extract Anxiolytic and Thrombolytic investigation of methanol extract of Piper nigrum L. fruits and Sesamum indicum L. seeds Investigation of in vitro Thrombolytic potential of ethanolic extract of Momordica charantia fruits: An anti-diabetic medicinal plant … Silver-Gold Alloy Nanoparticles Biosynthesized Using Cell-Free Extract of Bacillus Safensis LAU 13: Antifungal, Dye Degradation, Anti-Coagulant and Thrombolytic … … cunia Buch.-Ham. ex Roxb.(leaves): An experimental evaluation of the cytotoxicity, Thrombolytic, analgesic and neuropharmacological activities of its methanol extract Evaluation of antioxidant, Thrombolytic and cytotoxic potentials of methanolic extract of Aporosa wallichii Hook. f. leaves: an unexplored phytomedicine In vitro antioxidant and Thrombolytic activity of methanol extract of Sida acuta … , cytotoxic, Thrombolytic and membrane stabilizing potential of different extracts of Cheilanthes tenuifolia and Stigmasterol isolation from n-hexane extract In vitro Thrombolytic, anthelmintic, anti-oxidant and cytotoxic activity with phytochemical screening of methanolic extract of Xanthium indicum leaves Investigation of in vitro Thrombolytic and anti-helminthic activity and in vivo anxiolytic and antidepressant potentiality with phytochemical nature of methanolic extract of … … of carbon tetrachloride fraction of Actinodaphne angustifolia Nees (Lauraceae) leaf extract for antioxidant, cytotoxic, Thrombolytic and antidiarrheal properties Screening and evaluation of antioxidant, antimicrobial, cytotoxic, Thrombolytic and membrane stabilizing properties of the methanolic extract and solvent-solvent … Studies of preliminary phytochemical screening, membrane stabilizing activity, Thrombolytic activity and in-vitro antioxidant activity of leaf extract of Citrus hystrix Thrombolytic and cytotoxic activity of methanolic extract of Commelina benghalensis (Family: Commelinaceae) Leaves Evaluation of Thrombolytic activity and Brine Shrimp Lethality Bioassay of Methanol extract of stems of Tinospora crispa In Vitro Assessment of Antioxidant, Thrombolytic, Antimicrobial Activities of Medicinal Plant Pandanus odoratissimus L. Leaves Extract Preliminary phytochemical, cytotoxic, Thrombolytic and antioxidant activities of the methanol extract of Murraya exotica Linn. leaves Thrombolytic activity of an aqueous extract of tempe The combination of Astragalus membranaceus extract and ligustrazine to improve the inflammation
Xenoestrogens are a type of xenohormone that imitates estrogen. They can be either synthetic or natural chemical compounds. Synthetic xenoestrogens include some widely used industrial compounds, such as PCBs, BPA, and phthalates, which have estrogenic effects on a living organism even though they differ chemically from the estrogenic substances produced internally by the endocrine system of any organism. Natural xenoestrogens include phytoestrogenswhich are plant-derived xenoestrogens. Because the primary route of exposure to these compounds is by consumption of phytoestrogenic plants, they are sometimes called "dietary estrogens". Mycoestrogens, estrogenic substances from fungi, are another type of xenoestrogen that are also considered mycotoxins. Xenoestrogens are clinically significant because they can mimic the effects of endogenous estrogen and thus have been implicated in precocious puberty and other disorders of the reproductive system.[1][2] Xenoestrogens include pharmacological estrogens (in which estrogenic action is an intended effect, as in the drug ethinylestradiol used in contraceptive pills), but other chemicals may also have estrogenic effects. Xenoestrogens have been introduced into the environment by industrial, agricultural and chemical companies and consumers only in the last 70 years or so, but archiestrogens exist naturally. Some plants (like the cereals and the legumes) are using estrogenic substances possibly as part of their natural defence against herbivore animals by controlling their fertility.[3][4] The potential ecological and human health impact of xenoestrogens is of growing concern.[5] The word xenoestrogen is derived from the Greek words ξένο (xeno, meaning foreign), οἶστρος (estrus, meaning sexual desire) and γόνο (gene, meaning "to generate") and literally means "foreign estrogen". Xenoestrogens are also called "environmental hormones" or "EDC" (Endocrine Disrupting Compounds). Most scientists that study xenoestrogens, including The Endocrine Society, regard them as serious environmental hazards that have hormone disruptive effects on both wildlife and humans.[6][7][8][9][10] Xenoestrogen exposure and mechanisms of endocrine disruption Non-genomic effects of Xenoestrogen mixtures Xenoestrogen regulation of ERα/ERβ balance in hormone-associated cancers Inhibition of testicular steroidogenesis by the Xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased … Effects of maternal Xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring The Xenoestrogen Bisphenol A Induces Growth, Differentiation, and c-fos Gene Expression in the Female Reproductive Tract Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG) 1 Exposure to environmentally relevant doses of the Xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland Long-term effects of fetal exposure to low doses of the Xenoestrogen bisphenol-A in the female mouse genital tract Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways The Xenoestrogen bisphenol A induces inappropriate androgen receptor activation and mitogenesis in prostatic adenocarcinoma cells Effects of Xenoestrogen treatment on zona radiata protein and vitellogenin expression in Atlantic salmon (Salmo salar) Developing a marker of exposure to Xenoestrogen mixtures in human serum. Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT … -mediated extracellular signal-regulated kinase signaling in the rat cerebellar cortex: potent nongenomic agonist and endocrine disrupting activity of the Xenoestrogen … Degradation of the Xenoestrogen nonylphenol
Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts activation of the glucocorticoid-receptor complex Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: relevance to brain aging. Ligand-specific glucocorticoid receptor activation in human platelets Membrane glucocorticoid receptor activation induces proteomic changes aligning with classical glucocorticoid effects Hepatic transcriptome response to glucocorticoid receptor activation in rainbow trout Environmental endocrine disruptors promote adipogenesis in the 3T3‐L1 cell line through glucocorticoid receptor activation glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long range interactions activation of the glucocorticoid receptor in acute inflammation: the SEDIGRAM concept Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activation Multiple and cooperative trans-activation domains of the human glucocorticoid receptor glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model Enhancement of p53 activity and inhibition of neural cell proliferation by glucocorticoid receptor activation glucocorticoid receptor activation selectively hampers N-methyl-D-aspartate receptor dependent hippocampal synaptic plasticity in vitro Construction and characterization of a reporter gene cell line for assessment of human glucocorticoid receptor activation Glycyrrhizic acid and 18β-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3β signaling and glucocorticoid receptor activation Acute restraint stress enhances hippocampal endocannabinoid function via glucocorticoid receptor activation Cell-type-specific impact of glucocorticoid receptor activation on the developing brain: a cerebral organoid study Analysis of chromatin dynamics during glucocorticoid receptor activation Subunit dissociation as a possible mechanism of glucocorticoid receptor activation glucocorticoid receptor activation in the rat nucleus of the solitary tract facilitates memory consolidation: involvement of the basolateral amygdala Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia glucocorticoid receptor activation of the IκBα promoter within chromatin glucocorticoid receptor activation impairs hippocampal plasticity by suppressing BDNF expression in obese mice Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins Progesterone and glucocorticoid receptor activation in meningiomas Lesion‐induced plasticity in rat vestibular nucleus neurones dependent on glucocorticoid receptor activation The endocrine disrupting chemical tolylfluanid alters adipocyte metabolism via glucocorticoid receptor activation glucocorticoid receptor activation lowers the threshold for NMDA-receptor-dependent homosynaptic long-term depression in the hippocampus through activation of … glucocorticoid receptor activation signals through forkhead transcription factor 3a in breast cancer cells glucocorticoid receptor activation and inactivation in cultured human lymphocytes. activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer Carbenoxolone increases hepatic insulin sensitivity in man: a novel role for 11-oxosteroid reductase in enhancing glucocorticoid receptor activation … basolateral amygdala enhances memory consolidation via an interaction with the β-adrenoceptor–cAMP pathway: dependence on glucocorticoid receptor activation glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma Psychological stress suppresses innate IFN-γ production via glucocorticoid receptor activation: Reversal by the anxiolytic chlordiazepoxide glucocorticoid receptor activation stimulates the sodium-chloride cotransporter and influences the diurnal rhythm of its phosphorylation Cell-type specific impact of glucocorticoid receptor activation on the developing brain glucocorticoid receptor activation induces decrease of hippocampal astrocyte number in rats Histone acetyltransferase complexes can mediate transcriptional activation by the major glucocorticoid
OBESOGEN A chemical or other factor that disturbs a body's normal processes, causing it to tend toward obesity. Obesogens are foreign chemical compounds that disrupt normal development and balance of lipid metabolism and lead to obesity. MECHANISMS OF OBESOGEN ACTION •Increase of adipocyte number and size •Altering basal metabolic rate and energy homeostasis •Changing hypothalamic regulation of appetite and satiety •Reduced expression of brown adipocyte marker gene •Impaired glucose uptake and insulin signaling •Alteration of insulin sensitivity at the organ level •Alteration of endocrine regulation of adipose tissue development Is bisphenol A an environmental Obesogen? Transgenerational inheritance of prenatal Obesogen exposure History of the Obesogen field: looking back to look forward … inheritance of increased fat depot size, stem cell reprogramming, and hepatic steatosis elicited by prenatal exposure to the Obesogen tributyltin in mice Prenatal exposure to the environmental Obesogen tributyltin predisposes multipotent stem cells to become Adipocytes The environmental Obesogen tributyltin chloride acts via peroxisome proliferator activated receptor gamma to induce Adipogenesis in murine 3T3-L1 preAdipocytes Polychlorinated biphenyl 153 is a diet-dependent Obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice The environmental Obesogen bisphenol A promotes Adipogenesis by increasing the amount of 11β-hydroxysteroid dehydrogenase type 1 in the Adipose tissue of … Microbial metabolite delta-valerobetaine is a diet-dependent Obesogen Obesogen effects after perinatal exposure of 4, 4′-sulfonyldiphenol (Bisphenol S) in C57BL/6 mice Ancestral perinatal Obesogen exposure results in a transgenerational thrifty phenotype in mice The mammalian “Obesogen” tributyltin targets hepatic triglyceride accumulation and the transcriptional regulation of lipid metabolism in the liver and brain of … Endocrine aspects of environmental “Obesogen” pollutants Triflumizole is an Obesogen in mice that acts through peroxisome proliferator activated receptor gamma (PPAR γ) The Obesogen hypothesis: a shift of focus from the periphery to the hypothalamus … and Dispersant Components on PPARγ Activity in Vitro and in Vivo: Identification of Dioctyl Sodium Sulfosuccinate (DOSS; CAS #577-11-7) as a Probable Obesogen Tributyltin and the Obesogen metabolic syndrome in a salmonid The Case for BPA as an Obesogen: Contributors to the Controversy Environmental Obesogen tributyltin chloride leads to abnormal hypothalamic-pituitary-gonadal axis function by disruption in kisspeptin/leptin signaling in female rats Expression of Obesity markers and Persistent Organic Pollutants levels in Adipose tissue of obese patients: reinforcing the Obesogen hypothesis? The Obesogen tributyltin induces abnormal ovarian Adipogenesis in adult female rats Effects of arsenic on adipocyte metabolism: Is arsenic an Obesogen? Unraveling the mode of action of an Obesogen: mechanistic analysis of the model Obesogen tributyltin in the 3T3-L1 cell line Current research approaches and challenges in the Obesogen field Examining the responses of the zebrafish (Danio rerio) gastrointestinal system to the suspected Obesogen diethylhexyl phthalate Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver Multigenerational study of the Obesogen effects of bisphenol S after a perinatal exposure in C57BL6/J mice fed a high fat diet Obesity III: Obesogen assays: Limitations, strengths, and new directions The Obesogen hypothesis: current status and implications for human health Transgenerational
Plant metabolism of Xenobiotics Microbial metabolism of Xenobiotics: fundamental and applied research Higher plant metabolism of Xenobiotics: the'green liver'concept. A simple theory regarding ambimobility of Xenobiotics with special reference to the nematicide, oxamyl Intracellular binding and transport of hormones and Xenobiotics by glutathiones-transferases Model for uptake of Xenobiotics into plants: validation with bromacil experiments Biodegration of s-triazine Xenobiotics Functional toxicology: a new approach to detect biologically active Xenobiotics. Incorporation of Xenobiotics into soil humus Nature and significance of microbial cometabolism of Xenobiotics Mebolism of drugs and other Xenobiotics in the gut lumen and wall Organics and Xenobiotics in Soil The effects of Xenobiotics on fish tissues: morphological studies. Microbial metabolism of sulfurand phosphorus-containing Xenobiotics The comparative metabolism of Xenobiotics Cutaneous metabolism of Xenobiotics Determination of metabolites of Xenobiotics in the bile of fish from polluted waterways ARE-and TRE-mediated Regulation of Gene Expression: RESPONSE TO Xenobiotics AND ANTIOXIDANTS (∗) The hepatic gluthathione system—influences of Xenobiotics Biliary excretion of drugs and other Xenobiotics Screening for ligninolytic fungi applicable to the biodegradation of Xenobiotics Glutathione S-transferases in relation to their role in the biotransformation of Xenobiotics Respiratory tract uptake of inhalants and metabolism of Xenobiotics Differential induction of distinct glutathione-S-transferases of wheat by Xenobiotics and by pathogen attack Biotransformation and induction: implications for toxicity, bioaccumulation and monitoring of environmental Xenobiotics in fish. The effects of Xenobiotics on the structure and function of thyroid follicular and C-cells The pulmonary uptake, accumulation, and metabolism of Xenobiotics The role of structure in the disposition of halogenated aromatic Xenobiotics. Influence of Xenobiotics on rainbow trout liver estrogen receptor and vitellogenin gene expression Chemical carcinogenesis in feral fish: uptake, activation, and detoxication of organic Xenobiotics. Induction of drug-metabolizing enzymes by Xenobiotics Predicting the cytochrome P450 mediated metabolism of Xenobiotics. Plasma lecithin: cholesterol acyltransferase—reference values and effects of Xenobiotics Intestinal absorption and metabolism of Xenobiotics Evaluation of a detoxification regimen for fat stored Xenobiotics Degradation of Xenobiotics by white rot fungi Oxidative stress in fish exposed to model Xenobiotics. Oxidatively modified forms of Cu, Zn-superoxide dismutase as potential biomarkers Extent of cutaneous metabolism during percutaneous absorption of Xenobiotics Phloem mobility of Xenobiotics: I. Mathematical model unifying the weak acid and intermediate permeability theories Hepatic activities of xenobiotic metabolizing enzymes and biliary levels of Xenobiotics in English sole (Parophrys vetulus) exposed to environmental contaminants IN VITRO METABOLISM OF Xenobiotics IN SOME MARINE ANIMALS* A spreadsheet-based box model to predict the fate of Xenobiotics in a municipal wastewater treatment plant Thrombogenic effects of Xenobiotics … responses of the lysosomal system and NADPH-ferrihemoprotein reductase in molluscan digestive cells to environmental and experimental exposure to Xenobiotics Endocrine effects of prenatal exposure to PCBs, dioxins, and other Xenobiotics: implications for policy and future research. Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to Xenobiotics in rats. Evaluation of models for predicting terrestrial food chain behavior of Xenobiotics The metabolism of Xenobiotics by certain extrahepatic organs and its relation to toxicity Assessment of hepatic function with Xenobiotics Nephrotoxicity
The role of animal behaviour in the study of endocrine-disrupting chemicals endocrine disrupting chemicals and disease susceptibility Ten years of mixing cocktails: a review of combination effects of endocrine-disrupting chemicals endocrine-disrupting chemicals and public health protection: a statement of principles from The endocrine Society New modes of action for endocrine-disrupting chemicals endocrine-disrupting chemicals: an endocrine Society scientific statement Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Thyroid effects of endocrine disrupting chemicals Cognitive effects of endocrine-disrupting chemicals in animals. endocrine-disrupting chemicals: from basic research to clinical practice endocrine disrupting chemicals in indoor and outdoor air Health effects of endocrine-disrupting chemicals on wildlife, with special reference to the European situation State of the science of endocrine disrupting chemicals 2012: summary for decision-makers Impact of environmental endocrine disrupting chemicals on the development of obesity endocrine‐disrupting chemicals and obesity development in humans: a review Immunomodulatory effects of environmental endocrine disrupting chemicals endocrine disrupting chemicals Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals Small fish models for identifying and assessing the effects of endocrine-disrupting chemicals Removal of endocrine-disrupting chemicals in activated sludge treatment works Heavy metals as endocrine-disrupting chemicals Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses endocrine-disrupting chemicals use distinct mechanisms of action to modulate endocrine system function endocrine-disrupting chemicals: associated disorders and mechanisms of action Occurrence and treatment trials of endocrine disrupting chemicals (EDCs) in wastewaters Definition, classification and mechanism of action of endocrine disrupting chemicals Sources of endocrine-disrupting chemicals in urban wastewater, Oakland, CA Review of the effects of endocrine-disrupting chemicals in birds Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity. Sorption and degradation of selected five endocrine disrupting chemicals in aquifer material endocrine disrupting chemicals in fish: developing exposure indicators and predictive models of effects based on mechanism of action The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals endocrine disrupting chemicals and sexual behaviors in fish–a critical review on effects and possible consequences Review of evidence: are endocrine-disrupting chemicals in the aquatic environment impacting fish populations? Occurrence and removal of endocrine disrupting chemicals in wastewater Occurrence of endocrine-disrupting chemicals in indoor dust Study on endocrine disrupting chemicals in wastewater treatment plants endocrine disrupting chemicals: a new and emerging public health problem? The EDKB: an established knowledge base for endocrine disrupting chemicals The male reproductive system and its susceptibility to endocrine disrupting chemicals Estrogen-like endocrine disrupting chemicals affecting puberty in humans--a review. endocrine disrupting chemicals targeting estrogen receptor signaling: identification and mechanisms of action Effects of endocrine-disrupting chemicals on adrenal function Degradation of five selected endocrine-disrupting chemicals in seawater and marine sediment Degradation of endocrine disrupting chemicals by ozone/AOPs endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity Analytical methodologies for determining the occurrence of endocrine disrupting chemicals in sewage treatment plants and natural waters The challenge posed by endocrine-disrupting chemicals. Effects of Ag and Pt on photocatalytic degradation of endocrine disrupting chemicals in water Analysis of synthetic endocrine-disrupting chemicals in food: a review