An enlarged heart with hyperdense consolidation Mediastinal mass simulating enlarged heart, intracardiac catheterization in diagnosis Association of circulatory iron deficiency with an enlarged heart in patients with end-stage kidney disease An enlarged heart: A Personal History The relation of the position of the normal and the enlarged heart to the electrocardiogram Interobserver variability of vertebral heart size measurements in dogs with normal and enlarged hearts Aging is associated with a decline in Atg9b‐mediated autophagosome formation and appearance of enlarged mitochondria in the heart Overgrowth and enlarged heart in Mouse Fetuses with Maternally Inherited ThP and twLub2: An Example of Genomic Imprinting in Animals Some effects of digoxin on the heart and circulation in man: Digoxin in enlarged hearts not in clinical congestive failure Etiology of enlarged heart: A Rare Pancreatic Tumor: 565 Impact of follow-up on the success rate of the cryosurgical maze procedure in patients with rheumatic heart disease and enlarged atria Radiographic conundrum: what is the cause of enlarged heart in this patient with Down's syndrome? Melville's Poetry: Toward the enlarged heart: A Thematic Study of Three Ignored Major Poems Survey echocardiography. A comparative evaluation of enlarged heart chambers in the echocardiogram and the plain x-ray Case of enlarged heart, the Consequence of Ossification of the Mitral Valves During a routine physical, my doctor performed a chest x-ray. He said it showed I have an enlarged heart. What made him say this and should I be worried? enlarged heart caused by massive subepicardial lipomatosis with idiopathic dilatation of the right cavities Athletic heart syndrome (AHS), a benign condition caused by pro-longed, intense physical training, is characterized by an enlarged heart, altered cardiac rate and … LIV. The case of a man, whose heart was found enlarged to a very uncommon size heart failure due to enlarged tonsils and adenoids: The cardiorespiratory syndrome of increased airway resistance A New Concept to Restore the Failing enlarged Ischemic heart: Preliminary Report CardioClasp changes left ventricular shape acutely in enlarged canine heart A ten times enlarged model of artificial heart valve flow The relation between cardiac size and cardiac output per minute following the administration of digitalis in dogs in which the heart is enlarged were present; the heart was enlarged, together with its large Restoring the remodeled enlarged left ventricle: experimental benefits of in vivo porcine cardioreduction in the beating open heart Circulating Inflammatory Biomarkers and enlarged Perivascular Spaces: the Framingham heart Study (P1-1. Virtual) Independent and incremental value of severely enlarged left atrium in risk stratification of very elderly patients with chronic systolic heart failure Markedly enlarged right atrium associated with physical signs of tricuspid regurgitation: A cause of congestive heart failure in the elderly enlarged RIGHT SIDE OF THE heart (COMPARED WITH THE LEFT) … OF PRESSURE ON THE heart, WITH REFERENCE TO THE ADVISABILITY OF DECOMPRESSION OF GREATLY enlarged heartS; EXPERIMENTAL STUDY enlarged Racing heart in a Nine-Year-Old Girl appreciable" clubbing." The heart was enlarged to the The heart was enlarged (80G, normal 23-27G–Coppoletta and Wolbach, 1933) and
Human monkeypox Human monkeypox: an emerging zoonosis Reemergence of monkeypox: prevalence, diagnostics, and countermeasures Human monkeypox, 1970-79 Human monkeypox: clinical features of 282 patients The detection of monkeypox in humans in the Western Hemisphere Reemergence of human monkeypox in Nigeria, 2017 A tale of two clades: monkeypox viruses Human monkeypox Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. Human monkeypox: confusion with chickenpox. Two cases of monkeypox imported to the United Kingdom, September 2018 Human monkeypox: an emerging zoonotic disease Human monkeypox: a study of 2,510 contacts of 214 patients Emergence of monkeypox—west and central Africa, 1970–2017 monkeypox transmission and pathogenesis in prairie dogs The transmission potential of monkeypox virus in human populations Clinical characteristics of human monkeypox, and risk factors for severe disease Re-emergence of human monkeypox in Zaire in 1996. monkeypox virus: ecology and public health significance Human monkeypox: secondary attack rates Re-emergence of monkeypox in Africa: a review of the past six years monkeypox virus Emergence of monkeypox as the most important orthopoxvirus infection in humans Diagnosis of imported monkeypox, Israel, 2018 Endemic human monkeypox, democratic Republic of Congo, 2001–2004 The role of squirrels in sustaining monkeypox virus transmission. Clinical manifestations of human monkeypox influenced by route of infection A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo A preliminary assessment of silver nanoparticle inhibition of monkeypox virus plaque formation Outbreak of human monkeypox in Nigeria in 2017–18: a clinical and epidemiological report Analysis of the monkeypox virus genome Status of human monkeypox: clinical disease, epidemiology and research Human monkeypox. Human-to-human transmission of monkeypox virus, United Kingdom, October 2018 Detection of monkeypox virus with real-time PCR assays Ecological niche and geographic distribution of human monkeypox in Africa monkeypox: an emerging infection for humans? Modelling human-to-human transmission of monkeypox Update: multistate outbreak of monkeypox--Illinois, Indiana, Kansas, Missouri, Ohio, and Wisconsin, 2003 Discovery of monkeypox in Sudan Human monkeypox: a newly emerged orthopoxvirus zoonosis in the tropical rain forests of Africa. Isolation of monkeypox virus from wild squirrel infected in nature. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo Multistate outbreak of monkeypox--Illinois, Indiana, and Wisconsin, 2003 Smallpox vaccine–induced antibodies are necessary and sufficient for protection against monkeypox virus Human monkeypox infection: a family cluster in the midwestern United States A case of imported monkeypox in Singapore Exportation of monkeypox virus from the African continent Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections The changing epidemiology of human monkeypox—A potential threat? A systematic review Outbreaks of disease suspected of being due to human monkeypox virus infection in the Democratic Republic of Congo in 2001 Human monkeypox and smallpox viruses: genomic comparison Virulence differences between monkeypox virus isolates from West Africa and the Congo basin A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy Human monkeypox: epidemiologic and clinical characteristics, diagnosis, and prevention … of acute-phase humoral immunity to monkeypox: use of
Fasting and cancer : molecular mechanisms and clinical application Fasting and cancer treatment in humans: A case series report Effects of short-term Fasting on cancer treatment Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients Fasting glucose is a risk factor for breast cancer : a prospective study Fasting insulin and outcome in early-stage breast cancer : results of a prospective cohort study Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy Fasting serum glucose level and cancer risk in Korean men and women Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria Prolonged nightly Fasting and breast cancer prognosis Intermittent Fasting in the prevention and treatment of cancer Fasting -mimicking diet and hormone therapy induce breast cancer regression Fasting -mimicking diet and markers/risk factors for aging, diabetes, cancer , and cardiovascular disease A review of Fasting effects on the response of cancer to chemotherapy Fasting and caloric restriction in cancer prevention and treatment Autophagy and intermittent Fasting : the connection for cancer therapy? Fasting to enhance cancer treatment in models: the next steps The effect of caloric restriction and Fasting on cancer Fasting plasma amino acid levels in cancer patients Fibrinogen synthesis is elevated in Fasting cancer patients with an acute phase response Fasting blood glucose levels provide estimate of duration and progression of pancreatic cancer before diagnosis Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to Fasting and improve chemotherapeutic index Prolonged nightly Fasting and breast cancer risk: findings from NHANES (2009–2010) Resectability of presymptomatic pancreatic cancer and its relationship to onset of diabetes: a retrospective review of CT scans and Fasting glucose values prior to … Fasting blood glucose level and prognosis in non-small cell lung cancer (NSCLC) patients The effects of short-term Fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study Energy and caloric restriction, and Fasting and cancer : a narrative review Fasting -mimicking diet plus chemotherapy in breast cancer treatment The effects of short-term Fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer : a randomized cross-over pilot … Current Evidence and Directions for Intermittent Fasting During cancer Chemotherapy Fasting C-peptide levels and death resulting from all causes and breast cancer : the health, eating, activity, and lifestyle study Glucose flux in relation to energy expenditure in malnourished patients with and without cancer during periods of Fasting and feeding Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial Temporal association of changes in Fasting blood glucose and body mass index with diagnosis of pancreatic cancer Fasting cycles potentiate the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models … term Fasting and its combination with a Fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities
Erasing fear memories with extinction training extinction training regulates neuroadaptive responses to withdrawal from chronic cocaine self-administration Fear erasure in mice requires synergy between antidepressant drugs and extinction training Functional communication training with and without extinction and punishment Renewal of formerly conditioned fear in rats after extensive extinction training extinction training in conjunction with a partial agonist of the glycine site on the NMDA receptor erases memory trace Effectiveness of functional communication training with and without extinction and punishment: A summary of 21 inpatient cases Ventral medial prefrontal cortex and emotional perseveration: the memory for prior extinction training Increasing response variability of mand frames with script training and extinction Rapid remission of conditioned fear expression with extinction training paired with vagus nerve stimulation Different neural substrates mediate cocaine seeking after abstinence versus extinction training : a critical role for the dorsolateral caudate–putamen Behavior potentiality as a joint function of the amount of training and the degree of hunger at the time of extinction. Resistance to punishment and extinction following training with shock or nonreinforcement. Prefrontal infusion of PD098059 immediately after fear extinction training blocks extinction‐associated prefrontal synaptic plasticity and decreases prefrontal ERK2 … Post-retrieval extinction training enhances or hinders the extinction of morphine-induced conditioned place preference in rats dependent on the retrieval-extinction … Consequences of extinction training on associative and non-associative fear in a mouse model of Posttraumatic Stress Disorder (PTSD) extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking Spontaneous recovery varies inversely with the training -extinction interval Conditioned place preference with morphine: the effect of extinction training on the reinforcing CR Updating fearful memories with extinction training during reconsolidation: a human study using auditory aversive stimuli Young and old Pavlovian fear memories can be modified with extinction training during reconsolidation in humans Retrieval of memory for fear-motivated training initiates extinction requiring protein synthesis in the rat hippocampus Enhancing endocannabinoid neurotransmission augments the efficacy of extinction training and ameliorates traumatic stress-induced behavioral alterations … Persistence and resistance to extinction in the domestic dog: Basic research and applications to canine training The effect of mindfulness training on extinction retention The effect of discrimination training on extinction. Facilitating translational science in anxiety disorders by adjusting extinction training in the laboratory to exposure-based therapy procedures extinction training during the reconsolidation window prevents recovery of fear Reducing escape behavior and increasing task completion with functional communication training , extinction and response chaining Combined brain‐derived neurotrophic factor with extinction training alleviate impaired fear extinction in an animal model of post‐traumatic stress disorder Ceftriaxone normalizes nucleus accumbens synaptic transmission, glutamate transport, and export following cocaine self-administration and extinction training Inhibition of spontaneous recovery of fear by mGluR5 after prolonged extinction training Promoting long-term inhibition of human fear responses by non-invasive transcutaneous vagus nerve stimulation during extinction training training ‐induced changes in the expression of GABAA‐associated genes in the amygdala after the acquisition and extinction of Pavlovian fear Effects of extinction alone and extinction plus functional communication training on covariation of problem behaviors
Testicular macrophage modulation of Leydig Cell steroidogenesis Mitochondrial function in Leydig Cell steroidogenesis Nitric oxide inhibits Leydig Cell steroidogenesis Vitamin E, aging and Leydig Cell steroidogenesis A role for kit receptor signaling in Leydig Cell steroidogenesis Long-term suppression of Leydig Cell steroidogenesisprevents Leydig Cell aging The peripheral-type benzodiazepine receptor is functionally linked to Leydig Cell steroidogenesis. The role of tumor necrosis factor-alpha in the regulation of mouse Leydig Cell steroidogenesis Leydig Cell steroidogenesis: unmasking the functional importance of mitochondria Energized, polarized, and actively respiring mitochondria are required for acute Leydig Cell steroidogenesis Age-dependent stimulation of Leydig Cell steroidogenesisby interleukin-1 isoforms Mitochondria-associated membrane formation in hormone-stimulated Leydig Cell steroidogenesis: role of ATAD3 Bacterial endotoxin lipopolysaccharide and reactive oxygen species inhibit Leydig Cell steroidogenesisvia perturbation of mitochondria Phthalates exert multiple effects on Leydig Cell steroidogenesis Regulation of Leydig Cell steroidogenesisby extracellular signal-regulated kinase 1/2: role of protein kinase A and protein kinase C signaling Leydig Cell steroidogenesisin aging rats cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig Cell steroidogenesis Protein kinase G-mediated stimulation of basal Leydig Cell steroidogenesis Effects of acute and chronic immobilization stress on rat Leydig Cell steroidogenesis Evidence to suggest nitric oxide is an interstitial regulator of Leydig Cell steroidogenesis Functional Compensation by Egr4 inEgr1-Dependent Luteinizing Hormone Regulation and Leydig Cell steroidogenesis Direct stimulatory effects of insulin-like growth factor-I on Leydig Cell steroidogenesisin primary culture Sildenafil treatment in vivo stimulates Leydig Cell steroidogenesisvia the cAMP/cGMP signaling pathway Tumor necrosis factor-α inhibits Leydig Cell steroidogenesisthrough a decrease in steroidogenic acute regulatory protein expression Interleukin-1 inhibits Leydig Cell steroidogenesisin primary culture Transforming growth factor-β inhibits Leydig Cell steroidogenesisin primary culture Regulatory mechanism of Toona sinensis on mouse Leydig Cell steroidogenesis Upregulation of Peripubertal Rat Leydig Cell steroidogenesisFollowing 24 h In Vitro and In Vivo Exposure to Atrazine Effect of myxothiazol on Leydig Cell steroidogenesis: inhibition of luteinizing hormone-mediated testosterone synthesis but stimulation of basal steroidogenesis Effect of glutathione depletion on Leydig Cell steroidogenesisin young and old brown Norway rats The in vivo and in vitro stimulatory effects of cordycepin on mouse Leydig Cell steroidogenesis Proposed role for COUP-TFII in regulating fetal Leydig Cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig Cell steroidogenesis Interaction of thyroid hormone and steroidogenic acute regulatory (StAR) protein in the regulation of murine Leydig Cell steroidogenesis Effect of kisspeptin antagonist on goat in vitro Leydig Cell steroidogenesis Interleukin-1 inhibits Leydig Cell steroidogenesisprimarily by decreasing 17 alpha-hydroxylase/C17-20 lyase cytochrome P450 expression Aging and caloric restriction: effects on Leydig Cell steroidogenesis Stimulatory effect of LHRH and its agonists on Leydig Cell steroidogenesisin vitro The calcium signaling pathway regulates Leydig Cell steroidogenesisthrough a transcriptional cascade involving the nuclear receptor NR4A1 and the steroidogenic … The effect of midazolam on mouse Leydig Cell steroidogenesisand apoptosis Dual role of histamine in modulation of Leydig Cell steroidogenesisvia HRH1 and HRH2 receptor subtypes Environmental doses of arsenic exposure are associated with increased reproductive-age male urinary hormone excretion and in vitro Leydig
Eriodictyol Eriodictyol is a flavonoid, a type of plant compound that has been found to have potential health benefits. It is commonly found in various plants, including citrus fruits, parsley, and chamomile. Eriodictyol has been studied for its antioxidant, anti-inflammatory, and anti-cancer properties. Antioxidant Benefits of Eriodictyol: Antioxidants help protect the body against damage from harmful molecules called free radicals, which can cause oxidative stress and contribute to chronic diseases. Eriodictyol has been shown to scavenge free radicals and protect against oxidative stress. Anti-Inflammatory Properties of Eriodictyol: Chronic inflammation is linked to a variety of health problems, including heart disease, diabetes, and cancer. Eriodictyol has been found to inhibit the production of inflammatory molecules, which may help reduce inflammation in the body. Anti-Cancer Effects of Eriodictyol: Some studies have suggested that eriodictyol help inhibit the growth and spread of cancer cells. This is thought to be due to its ability to induce cell death in cancer cells and reduce the formation of new blood vessels that can nourish tumors. More research is needed to fully understand the potential anti-cancer effects of eriodictyol. Additional Studies The pharmacological and biological roles of eriodictyol Effect of eriodictyol on glucose uptake and insulin resistance in vitro Anti-inflammatory effects of eriodictyol in lipopolysaccharidestimulated raw 264.7 murine macrophages Efficient Synthesis of eriodictyol from l-Tyrosine in Escherichia coli eriodictyol prevents early retinal and plasma abnormalities in streptozotocin-induced diabetic rats Neuroinflammatory response to experimental stroke is inhibited by eriodictyol The isolation of eriodictyol and homoeriodictyol. An improved procedure Eriodictyol: a flavonoid antagonist of the TRPV1 receptor with antioxidant activity The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression eriodictyol inhibits high glucose‐induced oxidative stress and inflammation in retinal ganglial cells eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation Investigation of immunomodulatory and anti-inflammatory effects of eriodictyol through its cellular anti-oxidant activity Eriodictyol, a plant flavonoid, attenuates LPS‑induced acute lung injury through its antioxidative and anti‑inflammatory activity eriodictyol and naringenin inhibit the formation of AGEs: An in vitro and molecular interaction study Pharmacological activity of Eriodictyol: the major natural Polyphenolic Flavanone eriodictyol inhibits proliferation, metastasis and induces apoptosis of glioma cells via PI3K/Akt/NF-κB signaling pathway The anti-apoptotic and anti-oxidant effect of eriodictyol on UV-induced apoptosis in keratinocytes Binding model for eriodictyol to Jun-N terminal kinase and its anti-inflammatory signaling pathway Isolation of eriocitrin (eriodictyol 7-rutinoside) from lemon fruit (Citrus limon BURM. f.) and its antioxidative activity Phytochemical analysis of Vernonanthura tweedieana and a validated UPLC-PDA method for the quantification of eriodictyol De novo biosynthesis of apigenin, luteolin, and eriodictyol in the actinomycete Streptomyces albus and production improvement by feeding and spore … Biosynthesis of eriodictyol from tyrosine by Corynebacterium glutamicum eriodictyol attenuates arsenic trioxide-induced liver injury by activation of Nrf2 The Nrf2/HO-1 axis as targets for flavanones: neuroprotection by pinocembrin, naringenin, and eriodictyol eriodictyol inhibits survival and inflammatory responses and promotes apoptosis in rheumatoid arthritis fibroblast‐like synoviocytes through AKT/FOXO1 signaling eriodictyol
Cianidanol Cianidanol (Ci), also known as (+)-catechin, is a flavonoid, a type of plant-based compound with antioxidant properties. It is a natural polyphenolic compound found in various plants, including tea, cocoa, grapes, and fruits. Catechin is a member of the flavan-3-ol class of flavonoids, and it has been widely studied for its potential health benefits, including anti-inflammatory, anti-cancer, and anti-diabetic properties. It has also been found to improve cardiovascular health by reducing the risk of coronary heart disease, reducing blood pressure, and improving cholesterol levels. Furthermore, catechin has been shown to have neuroprotective effects and may help prevent cognitive decline and dementia. Overall, cianidanol (Ci) or catechin is a potent natural compound with various potential health benefits, and its consumption through a healthy diet or supplementation may help promote overall wellness. Antioxidant properties of Cianidanol: Cianidanol has strong antioxidant properties that may help protect the body against damage from free radicals, which are unstable molecules that can cause cellular damage and contribute to the development of chronic diseases like cancer, diabetes, and heart disease. Cianidanol for Cardiovascular Health: Studies have suggested that cianidanol may help improve cardiovascular health by promoting healthy blood pressure levels and reducing the risk of blood clots. It may also help improve blood vessel function and reduce inflammation, both of which can contribute to the development of cardiovascular disease. Cianidanol for Neuroprotective Effects: Some research has suggested that cianidanol may have neuroprotective effects, meaning it may help protect the brain against damage and reduce the risk of neurological disorders like Alzheimer's disease and Parkinson's disease. Cianidanol may do this by reducing inflammation and oxidative stress in the brain, as well as by promoting healthy blood flow and protecting brain cells from damage. Additional Studies Cianidanol therapy for HBe‐antigen‐positive chronic hepatitis: a multicentre, double‐blind study Development and evaluation of the essential oil from Magnolia fargesii for enhancing the transdermal absorption of theophylline and cianidanol cianidanol and its metabolites bind tightly to red cells and are responsible for the production of auto‐and/or drug‐dependent antibodies against these cells Effect of cianidanol on natural killer cell activity in patients with chronic B virus hepatitis. Effects of cianidanol on the blood lipid peroxide status in patients with chronic hepatitis. The effect of cianidanol on rat hepatic monooxygenase activities. Molecular docking analysis of cianidanol fromGinkgo biloba with HER2+ breast cancer target Photo-stability of several crystal forms of cianidanol Influence of cianidanol on specific and non-specific immune mechanisms. cianidanol ([+]-cyanidanol-3) prevents the development of abdominal adhesions in rats Synthesis of (3-2H)-and (3-3H)-cianidanol Photo-stability of cianidanol in aqueous solution and in the solid state The pathogenesis of cianidanol-induced fever Effect of cianidanol on chronic liver injury induced by carbon tetrachloride and on liver regeneration after partial hepatectomy in rats Effects of cianidanol (KB-53) on liver cirrhosis induced by CCl4 in rats: a pathological investigation Immunomodulating properties of cianidanol on responsiveness and function of human peripheral blood T-cells and K-cells The immunoenhancing effect of cianidanol (C) on macrophages and
Overexpression of Atg5 in mice activates autophagy and extends lifespan Rapamycin fed late in life extends lifespan in genetically heterogeneous mice Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans Dietary deprivation extends lifespan in Caenorhabditis elegans An antidepressant that extends lifespan in adult Caenorhabditis elegans rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice Increased fidelity of protein synthesis extends lifespan Loss of pregnancy‐associated plasma protein A extends lifespan in mice The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans D-beta-hydroxybutyrate extends lifespan in C. elegans The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+ PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice Restriction of amino acids extends lifespan in Drosophila melanogaster Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/− mice Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan Preventing age-related decline of gut compartmentalization limits microbiota dysbiosis and extends lifespan Dietary restriction extends lifespan through metabolic regulation of innate immunity Glycine supplementation extends lifespan of male and female mice Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice Lonicera japonica extends lifespan and healthspan in Caenorhabditis elegans Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan Roux‐en‐Y gastric bypass enhances energy expenditure and extends lifespan in diet‐induced obese rats New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis The starvation hormone, fibroblast growth factor-21, extends lifespan in mice The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila Single-dose CRISPR–Cas9 therapy extends lifespan of mice with Hutchinson–Gilford progeria syndrome Deletion of the Mitochondrial Superoxide Dismutase sod-2 extends lifespan in Caenorhabditis elegans Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age‐associated inflammation and oxidative stress in healthy … Royalactin extends lifespan of Caenorhabditis elegans through epidermal growth factor signaling Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome Methionine restriction extends lifespan in progeroid mice and alters lipid and bile acid metabolism Chemical activation of a food deprivation signal extends lifespan Growth hormone-releasing hormone disruption extends lifespan and regulates response
Menaquinone-4 Menaquinone-4, also known as MK-4, is a form of vitamin K2 that plays an essential role in blood clotting and bone metabolism. It is found naturally in some foods, such as animal products and fermented foods, or can be synthesized in the body from vitamin K1, which is primarily found in leafy green vegetables. MK-4 has been shown to have various health benefits, including the ability to improve bone health, reduce the risk of fractures, and prevent arterial calcification. It has also been studied for its potential to support cardiovascular health and improve cognitive function. MK-4 supplements are available and are often used in conjunction with other nutrients to support overall health and wellbeing. Menaquinone-4 for Bone Health: Menaquinone-4 has been shown to support bone health by activating proteins involved in bone formation and reducing the risk of fractures. In a clinical study, supplementation with menaquinone-4 was found to reduce the incidence of vertebral fractures in postmenopausal women with osteoporosis. Menaquinone-4 for Cardiovascular Health: Menaquinone-4 has been linked to cardiovascular health by inhibiting the buildup of calcium in arterial walls, which can lead to atherosclerosis (hardening of the arteries). A study found that supplementing with menaquinone-4 reduced arterial stiffness in healthy postmenopausal women. Menaquinone-4 for Dental Health: Menaquinone-4 has also been shown to promote dental health by enhancing the production of osteocalcin, a protein involved in tooth development and maintenance. In a study, menaquinone-4 supplementation improved dental health and reduced gum bleeding in patients with periodontal disease. It is important to note that while menaquinone-4 is generally considered safe for most people when taken in recommended doses, it may interact with certain medications and should be used with caution in people with certain medical conditions. As with any supplement, it is important to talk to your healthcare provider before taking menaquinone-4. Additional Studies Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women Conversion of phylloquinone (Vitamin K1) into menaquinone-4 (Vitamin K2) in mice: two possible routes for menaquinone-4 accumulation in cerebra of mice Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat Phylloquinone and menaquinone-4 distribution in rats: synthesis rather than uptake determines menaquinone-4 organ concentrations Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinone-4 Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4 menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments Neuroprotective effect of menaquinone-4 (MK-4) on transient global cerebral ischemia/reperfusion injury in rat Multiple dietary vitamin K forms are converted to tissue menaquinone-4 in mice Colonic absorption of menaquinone-4 and menaquinone-9 in rats menaquinone-4 in breast milk is derived from dietary phylloquinone menaquinone-4 accumulation in various
Pathophysiology of sex hormone binding globulin (SHBG): relation to insulin … components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG) Novel insights in SHBG regulation and clinical implications Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes Reference intervals for testosterone, androstenedione and SHBG levels in healthy females and males from birth until old age. A longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density Diurnal rhythms of serum total, free and bioavailable testosterone and of SHBG in middle‐aged men compared with those in young men Older men with low serum estradiol and high serum SHBG have an increased risk of fractures The biological variation of testosterone and sex hormone-binding globulin (SHBG) in polycystic ovarian syndrome: implications for SHBG as a surrogate marker of … The effect of extracts of the roots of the stinging nettle (Urtica dioica) on the interaction of SHBG with its receptor on human prostatic membranes Regulation of sex hormone binding globulin (SHBG) production in Hep G2 cells by insulin Obesity and menstrual irregularity: associations with SHBG, testosterone, and insulin Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG) Influence of SHBG Gene Pentanucleotide TAAAA Repeat and D327N Polymorphism on Serum Sex Hormone-Binding Globulin Concentration in Hirsute Women Postmenopausal levels of oestrogen, androgen, and SHBG and breast cancer: long-term results of a prospective study Muscle strength and serum testosterone, cortisol and SHBG concentrations in middle‐aged and elderly men and women Associations of sex-hormone-binding globulin (SHBG) with non-SHBG-bound levels of testosterone and estradiol in independently living men … of lutropin (LH), follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), cortisol … Association of the (TAAAA) n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum … Interrelations between sex hormone-binding globulin (SHBG), plasma lipoproteins and cardiovascular risk Localization of the human sex hormone-binding globulin gene (SHBG) to the short arm of chromosome 17 (17p12→ p13) Detection of haplotypes associated with prenatal death in dairy cattle and identification of deleterious mutations in GART, SHBG and SLC37A2 Sex Hormone-Binding Globulin (SHBG), estradiol and breast cancer Postmenopausal breast cancer risk in relation to sex steroid hormones, prolactin and SHBG (Sweden) The endocrine transition around menopause-a five years prospective study with profiles of gonadotropines, estrogens, androgens and SHBG among healthy women Serum total and unbound testosterone and sex hormone binding globulin (SHBG) in female acne patients treated with two different oral contraceptives. SHBG Gene Promoter Polymorphisms in Men Are Associated with Serum Sex Hormone-Binding Globulin, Androgen and Androgen Metabolite Levels, and Hip Bone … Polymorphisms in the SHBG Gene Influence Serum SHBG Levels in Women with Polycystic Ovary Syndrome The (TAAAA)n microsatellite polymorphism in the SHBG gene influences serum SHBG levels in women with polycystic ovary syndrome Effects of endurance