Resting energy expenditure: systematic organization and critique of prediction methods Relative changes in Resting energy expenditure during weight loss: a systematic review A new predictive equation for Resting energy expenditure in healthy individuals Dietary intake, Resting energy expenditure, weight loss and survival in cancer patients Resting energy expenditure in patients with pancreatitis Skeletal muscle metabolism is a major determinant of Resting energy expenditure. A new device for measuring Resting energy expenditure (REE) in healthy subjects Effect of different tumor types on Resting energy expenditure Comparison of Resting energy expenditure prediction methods with measured Resting energy expenditure in obese, hospitalized adults Assessment of Resting energy expenditure in mechanically ventilated patients Determinants of Resting energy expenditure in young children World Health Organization equations have shortcomings for predicting Resting energy expenditure in persons from a modern, affluent population: generation of a new … Resting energy expenditure in patients with chronic obstructive pulmonary disease Influence of methods used in body composition analysis on the prediction of Resting energy expenditure Resting energy expenditure and body composition in patients with newly detected cancer Measured Resting energy expenditure in children Cytokines, the acute-phase response, and Resting energy expenditure in cachectic patients with pancreatic cancer. Dietary intake and Resting energy expenditure in relation to weight loss in unselected cancer patients Prediction of Resting energy expenditure from fat-free mass and fat mass Increased Resting energy expenditure in patients with end‐stage renal disease Resting energy expenditure, activity energy expenditure and total energy expenditure at age 91–96 years Resting energy expenditure-fat-free mass relationship: new insights provided by body composition modeling Ascites increases the Resting energy expenditure in liver cirrhosis Raised Resting energy expenditure in Parkinson's disease and its relationship to muscle rigidity Metabolically active components of fat‐free mass and Resting energy expenditure in humans: recent lessons from imaging technologies Investigating heterogeneity in studies of Resting energy expenditure in persons with HIV/AIDS: a meta-analysis Measurement of Resting energy expenditure in a clinical setting Increased Resting energy expenditure and weight loss are related to a systemic inflammatory response in lung cancer patients. Total daily energy expenditure relative to Resting energy expenditure in clinically stable patients with COPD Validation of predictive equations for Resting energy expenditure in adult outpatients and inpatients Metabolically active components of fat free mass and Resting energy expenditure in nonobese adults Sex hormone suppression reduces Resting energy expenditure and β-adrenergic support of Resting energy expenditure The cystic fibrosis gene and Resting energy expenditure Estimation of Resting energy expenditure considering effects of race and diabetes status Resting energy expenditure should be measured in patients with cirrhosis, not predicted Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine Resting energy expenditure is increased in stable, malnourished HIV-infected patients Association between blood pressure and Resting energy expenditure independent of body size Resting energy expenditure and its determinants in hemodialysis patients Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement Resting energy expenditure and subsequent mortality risk in peritoneal dialysis

Smoking induces insulin resistance—a potential link with the insulin resistance syndrome Acute pain induces insulin resistance in humans High uric acid directly inhibits insulin signalling and induces insulin resistance Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice Olanzapine induces insulin resistance: results from a prospective study Central resistin overexposure induces insulin resistance through Toll-like receptor 4 Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria Porphyromonas gingivalis induces insulin resistance by Increasing BCAA Levels in Mice Angiotensin II induces insulin resistance independent of changes in interstitial insulin Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-α, overexpressed in human fat cells from insulin … The Estrogenic Effect of Bisphenol A Disrupts Pancreatic β-Cell Function In Vivo and induces insulin resistance In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. Benzene exposure induces insulin resistance in mice Acute noradrenergic activation induces insulin resistance in human skeletal muscle Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress High Uric Acid induces insulin resistance in Cardiomyocytes In Vitro and In Vivo ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes Hyperinsulinemia induces insulin resistance in dorsal root ganglion neurons Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules Increased tumor necrosis factor α–converting enzyme activity induces insulin resistance and hepatosteatosis in mice Resistin: a hormone which induces insulin resistance is increased in normal pregnancy Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation Hyperhomocysteinemia induces insulin resistance in male Sprague–Dawley rats Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity. A high-selenium diet induces insulin resistance in gestating rats and their offspring High glucose inhibits myogenesis and induces insulin resistance by down-regulating AKT signaling Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice Resistin is expressed in human hepatocytes and induces insulin resistance Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress Tumor necrosis

Ceramides in insulin resistance and lipotoxicity Obesity predisposes individuals to the development of insulin resistance in skeletal muscle and the liver, and researchers have recently proposed two mechanisms by which excess adiposity antagonizes insulin action in peripheral tissues. First, when adipocytes exceed their storage capacity, fat begins to accumulate in tissues not suited for lipid storage, leading to the formation of specific metabolites that inhibit insulin signal transduction. Second, obesity triggers a chronic inflammatory state, and cytokines released from either adipocytes or from macrophages infiltrating adipose tissue antagonize insulin action. The sphingolipid ceramide is a putative intermediate linking both excess nutrients (i.e. saturated fatty acids) and inflammatory cytokines (e.g. tumor necrosis factor-alpha, TNFalpha) to the induction of insulin resistance. Moreover, ceramide has been shown to be toxic in a variety of different cell types (e.g. pancreatic beta-cells, cardiomyocytes, etc.), and review of the literature reveals putative roles for the sphingolipid in the damage of cells and tissues which accompany diabetes, hypertension, cardiac failure, atherosclerosis, etc. In this review, I will evaluate the contribution of ceramides in the development of insulin resistance and the complications associated with metabolic diseases. Lipotoxicity What is Lipotoxicity? Lipotoxicity: when tissues overeat Lipotoxicity in the heart Lipotoxicity in the liver Oxidative stress and Lipotoxicity Insulin resistance, obesity and Lipotoxicity Diabetes and apoptosis: Lipotoxicity Fatty liver and Lipotoxicity Lipotoxicity in the heart Molecular mechanisms of Lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease Obesity and Lipotoxicity New aspects of Lipotoxicity in nonalcoholic steatohepatitis Mechanisms of Lipotoxicity in the cardiovascular system Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: genetic and clinical implications Lipotoxicity, overnutrition and energy metabolism in aging Renal lipid metabolism and Lipotoxicity Lipotoxicity and glucotoxicity in type 2 diabetes: effects on development and progression Mitochondrial dysfunction and Lipotoxicity Lipid homeostasis, Lipotoxicity and the metabolic syndrome Role of Lipotoxicity in endothelial dysfunction The role of ER stress in lipid metabolism and Lipotoxicity Lipotoxicity in NASH Fatty acids, Lipotoxicity and insulin secretion Underlying mechanisms of renal Lipotoxicity in obesity Lipid accumulation in non-adipose tissue and Lipotoxicity Molecular mechanisms of Lipotoxicity in nonalcoholic fatty liver disease Mechanisms of Lipotoxicity in NAFLD and clinical implications Cardiac Lipotoxicity: molecular pathways and therapeutic implications Saturated with fat: new perspectives on Lipotoxicity Role of obesity and Lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications The role of adipose tissue and Lipotoxicity in the pathogenesis of type 2 diabetes Role of glucotoxicity and Lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies Ceramides in insulin resistance and Lipotoxicity Adipose tissue expandability, Lipotoxicity and the metabolic syndrome—an allostatic perspective Gluttony, sloth and the metabolic syndrome: a roadmap to Lipotoxicity Insulin resistance, Lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009 Lipotoxicity in type 2 diabetic cardiomyopathy Oxidative capacity, Lipotoxicity, and mitochondrial damage in type 2 diabetes Triglyceride accumulation protects against fatty acid-induced Lipotoxicity Lipotoxicity: effects of dietary saturated and transfatty acids Dysfunctional fat cells, Lipotoxicity and type 2 diabetes Lipid signaling and Lipotoxicity

Pregabalin reduces cocaine self‐administration and relapse to cocaine seeking in the rat The 5-HT2C receptor agonist lorcaserin reduces cocaine self-administration, reinstatement of cocaine-seeking and cocaine induced locomotor activity Transcranial magnetic stimulation of medial prefrontal and cingulate cortices reduces cocaine self-administration: a pilot study Pharmacological stimulation of group ii metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in … The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues Injection of CART (cocaine-and amphetamine-regulated transcript) peptide into the nucleus accumbens reduces cocaine self-administration in rats PPL-138 (BU10038): A bifunctional NOP/mu partial agonist that reduces cocaine self-administration in rats Systemic delivery of a brain-penetrant TrkB antagonist reduces cocaine self-administration and normalizes TrkB signaling in the nucleus accumbens and prefrontal … Cebranopadol, a mixed opioid agonist, reduces cocaine self-administration through nociceptin opioid and mu opioid receptors Modified single prolonged stress reduces cocaine self-administration during acquisition regardless of rearing environment The hypocretin–orexin system regulates cocaine self‐administration via actions on the mesolimbic dopamine system The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice Potent and selective NOP receptor activation reduces cocaine self‐administration in rats by lowering hedonic set point Cebranopadol reduces cocaine self-administration in male rats: Dose, treatment and safety consideration LSP2-9166, an orthosteric mGlu4 and mGlu7 receptor agonist, reduces cocaine self-administration under a progressive ratio schedule in rats The effects of aerobic exercise on cocaine self-administration in male and female rats Hypocretin/Orexin regulation of dopamine signaling and cocaine self-administration is mediated predominantly by hypocretin receptor 1 Naltrexone–buprenorphine interactions: effects on cocaine self-administration Gamma-hydroxybutyric acid decreases intravenous cocaine self-administration in rats (-)-Stepholidine reduces cue-induced reinstatement of cocaine seeking and cocaine self-administration in rats Amphetamine maintenance therapy during intermittent cocaine self-administration in rats attenuates psychomotor and dopamine sensitization and reduces addiction … Hypocretin neurotransmission within the central amygdala mediates escalated cocaine self-administration and stress-induced reinstatement in rats Doses of GBR12909 that suppress cocaine self‐administration in non‐human primates substantially occupy dopamine transporters as measured by [11C] WIN35,428 … Oxytocin reduces cocaine seeking and reverses chronic cocaine-induced changes in glutamate receptor function Selective inhibition of M5 muscarinic acetylcholine receptors attenuates cocaine self‐administration in rats Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats Cholinergic influence on intravenous cocaine self-administration by rhesus monkeys Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self … α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats Ibudilast attenuates cocaine self-administration and prime-and cue-induced reinstatement of cocaine seeking in rats The effects of chronic buprenorphine on intake of heroin and cocaine in rats and its effects on nucleus accumbens dopamine levels during self-administration The melanin-concentrating hormone system modulates cocaine reward Reciprocal inhibitory effects of intravenous d-methamphetamine self-administration and wheel activity in rats Agents in development for the management of cocaine abuse Group II metabotropic glutamate receptors in the striatum of non-human primates: dysregulation following chronic cocaine self-administration Withdrawal from cocaine self-administration and Yoked cocaine Delivery

Potent antihypertensive action of dietary flaxseed in hypertensive patients Azilsartan as a Potent antihypertensive drug with possible pleiotropic cardiometabolic effects: a review study Potent antihypertensive effect of Hancornia speciosa leaves extract Potent antihypertensive activity of Thai-Lanna medicinal plants and recipes from “MANOSROI III” database A new, Potent antihypertensive drug: preliminary study of [2-(octahydro-1-azocinyl)-ethyl]-guanidine sulfate (guanethidine) Bromobenzofuran-based non-peptide antagonists of angiotensin II: GR138950, a Potent antihypertensive agent with high oral bioavailability Thidiazuron induced efficient in vitro multiplication and ex vitro conservation of Rauvolfia serpentina – a Potent antihypertensive drug producing plant Benzazepinone calcium channel blockers. 2. Structure activity and drug metabolism studies leading to Potent antihypertensive agents. Comparison with … Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1, 4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents New sulfhydryl compounds with Potent antihypertensive activities Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with Potent antihypertensive effects Peptide fragments from β-casein f (134–138), HLPLP, generated by the action of rat blood plasma peptidases show Potent antihypertensive activity Demonstration of the Potent antihypertensive activity of phenyl-2-aminoethyl sulfides 17β-(3-Furyl)-5β-androstane-3β, 14β, 17α-triol (PST 2238). A very Potent antihypertensive agent with a novel mechanism of action Synthesis and pharmacological evaluation of pyrroloazepine derivatives as Potent antihypertensive agents with antiplatelet aggregation activity Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl) adenosines: adenosine A2 receptor agonists with Potent antihypertensive effects Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl) adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with Potent antihypertensive … Octahydropyrazino [2', 3': 3, 4] pyrido [1, 2-a] indoles. A new class of Potent antihypertensive agents Labetalol: Potent antihypertensive agent that blocks both alpha-and beta-adrenergic receptors. … of some benzimidazole derivatives 4'-(5, 6-substitued-2-trifluoromethyl-benzoimidazol-1-ylmethyl)-biphenyl-2-carboxylic acid as Potent antihypertensive agents antihypertensive activity in a series of 1-piperazino-3-phenylindans with Potent 5-HT2-antagonistic activity Synthesis and Biological Evaluation of Potent antihypertensive Activity: 2-[(Substituted-phenyl amino)-phenyl-methyl]-1-[2'-(1H-tetrazol-5-yl) biphenyl-3-ylmethyl]-1H … Clonidine, a New Potent antihypertensive Agent. Discovery of Potent antihypertensive Ligands Substituted Imidazolyl Biphenyl Sulfonylureas Analogs as Angiotensin II AT1 Receptor Antagonists by Molecular … An Isocratic Assay Method Validation for the Determination of Five Most Potent antihypertensive Drugs by a New Generation Liquid Chromatographic … … of some substituted 6,7-dihydro-4-methoxy-7-methyl-7-substituted-5-oxo-5H-furo[3,2-g]chromene-9-sulfonate derivatives as Potent antihypertensive α-blocking and … HPLC/MS/MS analysis of 3-carbamyl-4-methylpyrrole analog MNP001, a highly Potent antihypertensive agent, in rat plasma SALT RESTRICTION COMBINED WITH RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM BLOCKADE IS A Potent antihypertensive STRATEGY IN PATIENTS … Pergolide: a Potent dopaminergic antihypertensive Article Details Predicting Potent antihypertensive compounds of pyridine derivatives by Molecular modeling approach PREDICTING Potent antihypertensive COMPOUNDS OF PYRIDINE DERIVATIVES BY MOLECULAR MODELING APPROACH. Highlighting of a New Flavonol Derivatives as a Potent antihypertensive Compound using Molecular Docking … in the Sensitivity of the External Iliac Artery to Specific Vasoconstrictors and Vasodilators Following Chronic Treatment with Reserpine, a Potent antihypertensive … Synthesis and antihypertensive activity of 1, 4-dihydropyridine derivatives with a 4-(disubstituted phenyl) ring and an aminoalkyl ester group: highly Potent and long … 56 Dietary nitrate: a novel but Potent antihypertensive strategy in uncontrolled hypertension and obstructive sleep apnoea syndrome Trequinsin, a Potent New antihypertensive Vasodilator in the Series of 2-(Arylimino)-3-alkyl-9, 10-dimethoxy-3, 4, 6, 7-tetrahydro-2H-pyrimido [6, 1-a] isoquinolin-4 …