Mitohormesis How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis) Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins Mitohormesis: promoting health and lifespan by increased levels of reactive oxygen species (ROS) Unraveling the truth about antioxidants: mitohormesis explains ROS-induced health benefits Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2 Muscle mitohormesis promotes longevity via systemic repression of insulin signaling … of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and dietary phytonutrients:“Mitohormesis” for health and … Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1 Mitohormesis primes tumor invasion and metastasis Mitohormesis in exercise training Nutritional ketosis and mitohormesis: potential implications for mitochondrial function and human health Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans Mitohormesis, an antiaging paradigm Mitohormesis in mice via sustained basal activation of mitochondrial and antioxidant signaling The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis A review of the inhibition of the mitochondrial ATP synthase by IF1 in vivo: reprogramming energy metabolism and inducing mitohormesis Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux Mitohormesis reprogrammes macrophage metabolism to enforce tolerance Exercise-induced mitohormesis for the maintenance of skeletal muscle and healthspan extension Regulation of the H+-ATP synthase by IF1: a role in mitohormesis Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling Mitohormesis, UPRmt, and the complexity of mitochondrial DNA landscapes in cancer … status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction … Mitohormesis in hypothalamic POMC neurons mediates regular exercise-induced high-turnover metabolism N‐acetyl‐l‐tyrosine is an intrinsic triggering factor of mitohormesis in stressed animals Mitohormesis; Potential implications in neurodegenerative diseases Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis Endogenous metabolites promote stress resistance through induction of mitohormesis Adhesion-mediated mechanosignaling forces mitohormesis Mitohormesis in muscle cells: a morphological, molecular, and proteomic approach A variety of mild stresses upregulate stanniocalcin-1 (STC-1) and induce mitohormesis in neural crest-derived cells N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties L-lactate protects skin fibroblasts against aging-associated mitochondrial dysfunction via mitohormesis Effects of low concentrations of rotenone upon mitohormesis in SH-SY5Y cells Fragile lifespan expansion by dietary mitohormesis in C. elegans Sestrin2, a regulator of thermogenesis and mitohormesis in brown adipose tissue Protect the species with mitohormesis? Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis How N-Acetylcysteine Supplementation Affects Redox Regulation, Especially at Mitohormesis and Sarcohormesis Level: Current Perspective Mitohormesis: another pleiotropic effect of statins? Mitohormesis Life-Span Extension by Axenic Dietary Restriction Is Independent of the Mitochondrial Unfolded Protein Response and Mitohormesis in Caenorhabditis elegans Differences in mitochondrial coupling

Reversal of obesity by targeted ablation of adipose tissue Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ Reversal of obesity-related hypoadiponectinemia by lifestyle intervention: a controlled, randomized study in obese adolescents Reversal of diet-induced obesity and diabetes in C57BL/6J mice Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats Leptin Activation of Corticosterone Production in Hepatocytes May Contribute to the Reversal of Obesity and Hyperglycemia in Leptin-Deficient ob/ob Mice Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a β3-adrenoceptor agonist Trends in fatness and the origins of obesity Reversal of obesity in the genetically obese fa/fa Zucker rat with an ephedrine/methylxanthines thermogenic mixture Reversal of Obesity-and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption.... Mifepristone (RU 486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity Obesity and sarcopenia after menopause are reversed by sex hormone replacement therapy Myocardial fatty acid oxidation rates remain elevated in ob/ob mice despite reversal of obesity and diabetes by caloric restriction Body weight regulation in obese and obese-reduced rats. Inflammation and the IKKβ/IκB/NF-κB axis in obesity-and diet-induced insulin resistance Polycythemia of obesity: further studies of its mechanism and a report of two additional cases Brain responses to obesogenic diets and diet-induced obesity Development of obesity in transgenic mice after genetic ablation of brown adipose tissue Hypothalamic obesity: the autonomic hypothesis and the lateral hypothalamus Role of Endoplasmic Reticulum Stress and c-Jun NH2-Terminal Kinase Pathways in Inflammation and Origin of Obesity and Diabetes Severe orthostatic hypotension following weight reduction surgery The role of beta3-adrenergic receptors in control of brown and white adipose tissues and of energy balance: Reversal of obesity by CL 316,243, a new beta3 … The liver in obesity and type 2 diabetes mellitus Effects of fasting and refeeding on blood pressure are determined by nutritional state, not by body weight change Maternal obesity is associated with younger age at obesity onset in US adolescent offspring followed into adulthood Thematic review series: adipocyte biology. Sympathetic and sensory innervation of white adipose tissue The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity Using mouse models to dissect the genetics of obesity Energy balance in reversible obesity Effect of diet on adipose tissue and skeletal muscle VLDL receptor and LPL: implications for obesity and hyperlipidemia Pathophysiologic changes of obesity Role of the autonomic nervous system in the development of ventromedial hypothalamic obesity Aspirin as a promoter of ephedrine-induced thermogenesis: potential use in the treatment of obesity The effects of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic obesity Brain somatic cross-talk: ghrelin, leptin and ultimate challengers of obesity Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation Pathogenesis of type 2 diabetes mellitus Internal regulation and the evolution of normal growth as the basis for prevention of obesity in

Anti-obesogenic and antidiabetic effects of plants and mushrooms Medicinal plants and phytochemicals with anti-obesogenic potentials: A review The anti-obesogenic effects of dietary berry fruits: A review Potential of enhancing anti-obesogenic agriceuticals by applying sustainable fertilizers during plant cultivation Mechanisms of action for the anti-obesogenic activities of phytochemicals The anti-obesogenic effects and underpinning mechanisms of fermented plant-based foods: A review Anti-obesogenic effects of WY14643 (PPAR-alpha agonist): Hepatic mitochondrial enhancement and suppressed lipogenic pathway in diet-induced obese mice Antioxidative, anti-inflammatory, anti-obesogenic, and antidiabetic properties of tea polyphenols—The positive impact of regular tea consumption as an … The conversion of β-carotene to vitamin A in adipocytes drives the anti-obesogenic effects of β-carotene in mice Saponins are responsible for the anti-obesogenic activity of Acacia concinna Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice Phenolic Profile, Antioxidant Activity, and Anti-obesogenic Bioactivity of Mao Luang Fruits (Antidesma bunius L.) Prawn shell chitosan has anti-obesogenic properties, influencing both nutrient digestibility and microbial populations in a pig model Anti-obesogenic effect of apple cider vinegar in rats subjected to a high fat diet Potential Anti-obesogenic Effects of Ginkgo biloba Observed in Epididymal White Adipose Tissue of Obese Rats Potential anti-obesogenic properties of non-digestible carbohydrates: specific focus on resistant dextrin The Allium Derivate Propyl Propane Thiosulfinate Exerts Anti-Obesogenic Effects in a Murine Model of Diet-Induced Obesity Prawn Shell Chitosan Exhibits Anti-Obesogenic Potential through Alterations to Appetite, Affecting Feeding Behaviour and Satiety Signals In Vivo Anti-Obesogenic Effects of Sulforaphane-Rich Broccoli (Brassica oleracea var. italica) Sprouts and Myrosinase-Rich Mustard (Sinapis alba L.) Seeds In Vitro and In … Selection of Thai medicinal plants with anti-obesogenic potential via in vitro methods Caffeic acid and hydroxytyrosol have anti-obesogenic properties in zebrafish and rainbow trout models Arabinoxylans and gelled arabinoxylans used as anti-obesogenic agents could protect the stability of intestinal microbiota of rats consuming high-fat diets Socioeconomic status and use of obesogenic and anti-obesity medications in the United States: a population-based study Anti-obesogenic and hypolipidemic effects of a glucagon-like peptide-1 receptor agonist derived from the saliva of the Gila monster Anti‐obesogenic effects of calcium prevent changes in the GLP‐1 profile in adult rats primed by early weaning Copaiba oleoresin presents anti-obesogenic effect and mitigates inflammation and redox imbalance in adipose tissue Anti-obesity natural products tested in juvenile zebrafish obesogenic tests and mouse 3T3-L1 adipogenesis assays Putative hormone with anti-obesogenic and insulin-sensitizing effect Zebrafish obesogenic test identifies anti‐adipogenic fraction in Moringa oreifera leaf extracts A long-term obesogenic high-fat diet in mice partially dampens the anti-frailty benefits of late-life intermittent fasting The Anti-Obesogenic Effect of Lean Fish Species Is Influenced by the Fatty Acid Composition in Fish Fillets Obesity causes irreversible mitochondria failure in visceral adipose tissue despite successful anti-obesogenic lifestyle-based interventions Molecular Mechanisms of Adipogenesis: The Anti-Obesogenic Role of AMP-Activated Protein Kinase and Recently Reported Plant Products Mechanistic analysis of Thai medicinal plants on anti-obesogenic activity [an abstract of dissertation and a summary of dissertation review] Investigating the antioxidant, immunomodulatory and anti-obesogenic propertiesof novel BSG-derived extracts and their potential as

The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta A new pancreatic lipase inhibitor from Broussonetia kanzinoki Quercetin is a promising pancreatic lipase inhibitor in reducing fat absorption in vivo Weight Gain Reduction in Mice Fed Panax ginseng Saponin, a Pancreatic Lipase Inhibitor Anti-obesity effects of galangin, a pancreatic lipase inhibitor in cafeteria diet fed female rats Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats Anti-obesity activity of hen egg anti-lipase immunoglobulin yolk, a novel pancreatic lipase inhibitor Antiobesity action of ɛ-polylysine, a potent inhibitor of pancreatic lipase Relationship between improved postprandial lipemia and low-density lipoprotein metabolism during treatment with tetrahydrolipstatin, a pancreatic lipase inhibitor High-Resolution Bioassay Profiling with Complemented Sensitivity and Resolution for Pancreatic Lipase Inhibitor Screening Proteinaceous pancreatic lipase inhibitor from the seed of Litchi chinensis Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini I. Producing organism, fermentation, isolation and biological activity Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini II. Chemistry and structure elucidation Elucidating the Biosynthetic Pathway for Vibralactone: A Pancreatic Lipase Inhibitor with a Fused Bicyclic β‐Lactone Kojic acid repurposing as a pancreatic lipase inhibitor and the optimization of its production from a local Aspergillus oryzae soil isolate Development of QSAR model using machine learning and molecular docking study of polyphenol derivatives against obesity as pancreatic lipase inhibitor Studies on the antiobesity activity of tetrahydrolipstatin, a potent and selective inhibitor of pancreatic lipase. Cassia grandis Lf nanodispersion is a hypoglycemic product with a potent α-glucosidase and pancreatic lipase inhibitor effect … aldol-lactonization (TMAL) reaction: A concise and highly diastereoselective route to β-lactones applied to the total synthesis of the potent pancreatic lipase inhibitor … In-vitro functional efficacy of extracts from Phyllanthus emblica, Eucalyptus globulus, Tinospora cordifolia as pancreatic lipase inhibitor and source of anti-oxidant in … Phytochemical and Biological Profile of Moricandia arvensis (L.) DC.: An Inhibitor of Pancreatic Lipase Theophylline extracted from fu brick tea affects the metabolism of preadipocytes and body fat in mice as a pancreatic lipase inhibitor The community management of chylous fistula using a pancreatic lipase inhibitor (orlistat) Proteinous pancreatic lipase inhibitor is responsible for the antiobesity effect of young barley (Hordeum vulgare L.) leaf extract Peptide inhibitor of pancreatic lipase selected by phage display using different elution strategies Synthesis and Study of a Lipophilic α-Keto Amide Inhibitor of Pancreatic Lipase Utilization of Agro-Waste of Piper longum for a Potential Pancreatic Lipase Inhibitor 5-Hydroxy-7-(4′-hydroxy-3′-methoxyphenyl)-1-phenyl-3-heptanone: a pancreatic lipase inhibitor isolated from Alpinia officinarum Operon for biosynthesis of lipstatin, the beta-lactone inhibitor of human pancreatic lipase Saponin isolates from cucumber (Cucumis sativus L.) fruit mesocarp and their activity as pancreatic lipase inhibitor Functional Imaging and Inhibitor Screening of Human Pancreatic Lipase by a Resorufin-Based Fluorescent Probe Large spectral changes accompany the conformational transition of human pancreatic lipase induced by acylation with the inhibitor

GSK3 inhibitors: development and therapeutic potential The conundrum of GSK3 inhibitors: is it the dawn of a new beginning? Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes GSK3 inhibitors and disease GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals GSK3 inhibitors in the therapeutic development of diabetes, cancer and neurodegeneration: past, present and future Immune checkpoint inhibition in syngeneic mouse cancer models by a silicasome nanocarrier delivering a GSK3 inhibitor The development of potent and selective bisarylmaleimide GSK3 inhibitors Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes Effects of GSK3 inhibitors on in vitro expansion and differentiation of human adipose-derived stem cells into adipocytes A modified EpiSC culture condition containing a GSK3 inhibitor can support germline-competent pluripotency in mice The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of … GSK3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms, Including p53 and Wnt Signaling Rats treated with AZD2858, a GSK3 inhibitor, heal fractures rapidly without endochondral bone formation Oral administration of a GSK3 inhibitor increases brain insulin-like growth factor I levels GSK3 inhibitor-induced dentinogenesis using a hydrogel QSAR, docking, and CoMFA studies of GSK3 inhibitors GSK3 inhibitor-BIO regulates proliferation of immortalized pancreatic mesenchymal stem cells (iPMSCs) GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis GSK3 inhibitors CHIR99021 and 6-bromoindirubin-3′-oxime inhibit microRNA maturation in mouse embryonic stem cells Testing Fmr1KO Phenotypes in Response to GSK3 Inhibitors: SB216763 versus AFC03127 From on‐target to off‐target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti‐Trypanosoma brucei drug … Donor cell engineering with GSK3 inhibitor–loaded nanoparticles enhances engraftment after in utero transplantation Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania GSK3 inhibitor ameliorates steatosis through the modulation of mitochondrial dysfunction in hepatocytes of obese patients GSK3 inhibitors enhance retinoic acid receptor activity and induce the differentiation of retinoic acid-sensitive myeloid leukemia cells EGF and a GSK3 inhibitor deplete junctional E-cadherin and stimulate proliferation in the mature mammalian ear Control of Hes7 Expression by Tbx6, the Wnt Pathway and the Chemical Gsk3 Inhibitor LiCl in the Mouse Segmentation Clock Glycogen synthase kinase 3 (GSK3) inhibitor, SB-216763, promotes pluripotency in mouse embryonic stem cells The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of β-catenin, a GSK3 substrate, in human glioblastoma cells Stable generation of serum‐and feeder‐free embryonic stem cell‐derived mice with full germline‐competency by using a GSK3 specific inhibitor The novel potent GSK3 inhibitor AF3581 reverts fragile X syndrome phenotype Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline‐competent embryonic