Curcumin Curcumin ameliorates arterial dysfunction and oxidative stress with aging Curcumin and aging Curcumin Extends Life Span, Improves Health Span, and Modulates the Expression of Age-Associated aging Genes in Drosophila melanogaster Dietary Curcumin ameliorates aging-related cerebrovascular dysfunction through the AMPK/uncoupling protein 2 pathway Curcumin induces heme oxygenase‐1 in normal human skin fibroblasts through redox signaling: Relevance for anti‐aging intervention Effects of resveratrol, Curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs Effect of Curcumin on aging retinal pigment epithelial cells Curcumin affects adipose tissue-derived mesenchymal stem cell aging through TERT gene expression Curcumin-functionalized silk biomaterials for anti-aging utility Curcumin induces ABCA1 expression and apolipoprotein AI-mediated cholesterol transmembrane in the chronic cerebral hypoperfusion aging rats Curcumin mitigates accelerated aging after irradiation in Drosophila by reducing oxidative stress Curcumin rescues aging-related loss of hippocampal synapse input specificity of long term potentiation in mice Therapeutic potential and recent advances of Curcumin in the treatment of aging-associated diseases Curcumin protects brain from oxidative stress through inducing expression of UCP2 in chronic cerebral hypoperfusion aging-rats Anti-aging role of Curcumin by modulating the inflammatory markers in albino wistar rats Antioxidative effect of Curcumin (Curcuma longa) on lipid peroxidation and lipofuscinogenesis in submandibular gland of D-galactose-induced aging male mice Modulation of ovarian structure and abdominal obesity in Curcumin-and flutamide-treated aging FSH-R haploinsufficient mice Curcumin and its potential for systemic targeting of inflamm-aging and metabolic reprogramming in cancer Effects of Curcumin Solid Dispersion on Blood Lipid and Antioxidative Capability in aging Rats [J] Curcumin preserves cognitive function and improve serum HDL in chronic cerebral hypoperfusion aging-rats Effect of Curcumin on antioxidant and detoxification mechanisms in the livers of aging rats. Curcumin promotes cholesterol efflux from brain through LXR/RXR-ABCA1-apoA1 pathway in chronic cerebral hypoperfusion aging-rats Curcumin supplementation effects on aging skeletal muscle … size of Curcumin nanocarriers and the ethanol on beta_1-integrin overexpression in fibroblasts: A regenerative pharmaceutical approach in skin repair and anti-aging … Mechanisms of Action of Curcumin on aging: Nutritional and Pharmacological Applications The Effects of Curcumin on Antioxidation and aging in Drosophila Caloric Restriction and Dietary Curcumin Improve Functional Outcomes of aging in Mice Anti-aging Effect of Free Curcumin and Niosome Entrapping Curcumin in H2O2-induced aging in Human Fibroblast Cell Lines Caloric Restriction and Dietary Curcumin Improve Functional Outcomes of aging in Mice Effect of aging on colonic chemoprevention by dietary Curcumin Effect of Curcumin on Learning and Memory of aging Mice Caused by D-galactose Curcumin Nanocrystals as Photodynamical Sensor Monitoring Ultraviolet Accelerated aging of HDPE Dietary supplementation with fish oil and Curcumin improves gait speed and mitochondrial function during aging The antioxidant Curcumin postpones ovarian aging in young and middle-aged mice Impact of Curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast Effect of Curcumin on ABCA 1, serum high density lipoprotein and total cholesterol in chronic cerebral hypoperfusion aging rats Prolonged Dietary Curcumin Supplementation Augments Nrf2 Nuclear Translocation and Attenuates Oxidative Stress in Skeletal Muscle of aging Rats Protective effect of Curcumin on fibroblast cells

Carnosine Carnosine, the protective, anti-aging peptide The roles of carnosine in aging of skeletal muscle and in neuromuscular diseases Would carnosine or a carnivorous diet help suppress aging and associated pathologies? aging, proteotoxicity, mitochondria, glycation, NAD+ and carnosine: possible inter-relationships and resolution of the oxygen paradox Carnosine and taurine treatments diminished brain oxidative stress and apoptosis in D-galactose aging model Synergistic effect of L-Carnosine and EGCG in the prevention of physiological brain aging … between energy metabolism, proteostasis, aging and Parkinson's disease: Possible causative role of methylglyoxal and alleviative potential of carnosine Skin beautification with oral non-hydrolized versions of carnosine and carcinine: Effective therapeutic management and cosmetic skincare solutions against oxidative … Carnosine: effect on aging-induced increase in brain regional monoamine oxidase-A activity aging-induced changes in brain regional serotonin receptor binding: Effect of Carnosine Platelet monoamine oxidase-A activity and aging: effect of carnosine Carnosine reverses the aging-induced down regulation of brain regional serotonergic system Carnosine: Multipurpose Anti-aging Nutrient Carnosine: The new anti-aging supplement … ” L-Carnosine (β-Alanyl-L-Histidine)? Cell Proliferative Activity as a Fundamental Property of a Natural Dipeptide Inherent to Traditional Antioxidant, Anti-aging … Treatment of skin aging and photoaging with innovative oral dosage forms of nonhydrolized carnosine and carcinine Can Carnosine Prevent the aging-Induced Changes of Blood Platelet and Brain Regional Monoamine Oxidase-A mRNA in Relation to its Activity? Anti-aging Effect of Carnosine and T_3, T_4 and IGF-Ⅰ Level in Serum of Mice Mounting evidence documents the ability of carnosine to prevent many of the detrimental effects of aging. Studies on the effect of carnosine in aging induced neurodegeneration in relation to brain regional serotonergic activity l-histidine and l-carnosine accelerate wound healing via regulation of corticosterone and PI3K/Akt phosphorylation in d-galactose-induced aging models in vitro and in … Anti-aging Effect of Carnosine and T_3, T_4 and IGF-Ⅰ Level in Serum of Mice Protective Effect of a Novel Anti-aging Facial Cream Containing Alteromonas Ferment Extract and Carnosine Against Environmental Pollution in Human … Anti-aging effects of L-histidine and L-carnosine on D-galactose-induced aging Inhibitory effect of carnosine and N-acetyl carnosine on LPS-induced microglial oxidative stress and inflammation D‐carnosine octylester attenuates atherosclerosis and renal disease in ApoE null mice fed a Western diet through reduction of carbonyl stress and inflammation Physiological implications of carnosine on the inflammation Carnosine has antinociceptive properties in the inflammation-induced nociceptive response in mice Neuroprotective effect of carnosine and cyclosporine-A against inflammation, apoptosis, and oxidative brain damage after closed head injury in immature rats The inhibition of inflammation by the promotion of spontaneous healing with L-carnosine (author's transl) inflammation as the common biological link between depression and cardiovascular diseases: Can carnosine exert a protective role? Physiological Implications of Carnosine on the inflammation Carnosine Decreases PMA-Induced Oxidative Stress and inflammation in Murine Macrophages Carnosine prevents Aβ-induced oxidative stress and inflammation in microglial cells: a key role of TGF-β1 Prophylactic administration of carnosine and melatonin abates the incidence of apoptosis, inflammation, and DNA damage induced by titanium dioxide nanoparticles … Physiological role of carnosine and homocarnosine in inflammation The promotion

Andrographis Paniculata Hepatoprotective activity of Andrographolide from Andrographis paniculata against carbontetrachloride. Andrographolide protects rat hepatocytes against paracetamol-induced damage In vitro and in vivo anti-inflammatory effects of Andrographolide. Hepatoprotective activity of Andrographolide against galactosamine & paracetamol intoxication in rats. A phase I trial of Andrographolide in HIV positive patients and normal volunteers Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata Antihyperglycemic effect of Andrographolide in streptozotocin-induced diabetic rats Choleretic Effect of Andrographolide in Rats and Guinea Pigs1 Synthesis and structure–activity relationships of Andrographolide analogues as novel cytotoxic agents Antiangiogenic activity of Andrographis paniculata extract and Andrographolide Inhibitory effect of Andrographolide from Andrographis paniculata on PAF-induced platelet aggregation Semisynthesis and in vitro anticancer activities of Andrographolide analogues Pharmacological aspects of Andrographis paniculata on health and its major diterpenoid constituent Andrographolide Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism (s) involved in its anti‐inflammatory effect In vitro α-glucosidase and α-amylase enzyme inhibitory effects of Andrographis paniculata extract and Andrographolide Andrographolide attenuates inflammation by inhibition of NF-κB activation through covalent modification of reduced cysteine 62 of p50 Solid–liquid extraction of Andrographolide from plants—experimental study, kinetic reaction and model Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB Hepatoprotective effect of Andrographolide against hexachlorocyclohexane-induced oxidative injury A novel antiinflammatory role for Andrographolide in asthma via inhibition of the nuclear factor-κB pathway Targeting of Liposomal Andrographolide to L.donovani-Infected Macrophages in Vivo Mechanisms of suppression of inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells by Andrographolide Synthesis and evaluation of antibacterial activities of Andrographolide analogues Andrographolide interferes with binding of nuclear factor‐κB to DNA in HL‐60‐derived neutrophilic cells Standardization of the Indian crude drug Kalmegh by high pressure liquid chromatographic determination of Andrographolide * Semisynthesis and cytotoxic activities of Andrographolide analogues Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function Suppression of rat neutrophil reactive oxygen species production and adhesion by the diterpenoid lactone Andrographolide Six new Andrographolide metabolites in rats Critical role of pro-apoptotic Bcl-2 family members in Andrographolide-induced apoptosis in human cancer cells Pharmacokinetic and oral bioavailability of Andrographolide from Andrographis paniculata fixed combination Kan Jang in rats and human Hypoglycemic and beta cell protective effects of Andrographolide analogue for diabetes treatment Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by Andrographolide Andrographolide: a new plant-derived antineoplastic entity on horizon Four new Andrographolide metabolites in rats A rapid method for isolation of Andrographolide from Andrographis paniculata Nees (Kalmegh) Experimental and clinical pharmacology of Andrographis paniculata and its major bioactive phytoconstituent Andrographolide Andrographolide up-regulates cellular-reduced glutathione level and protects cardiomyocytes against hypoxia/reoxygenation injury Neuroprotective effects of Andrographolide in a rat model of permanent cerebral ischaemia Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration Synthesis of Andrographolide derivatives and their TNF-α and IL-6 expression inhibitory activities A new BIS-Andrographolide Ether from Andrographis paniculata Nees

MDM2 antagonists attenuate the senescence-associated secretory phenotype Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells lose the ability to divide, essentially irreversibly, and secrete numerous proteases, cytokines and growth factors, termed the senescence-associated secretory phenotype (SASP). Senescent cells that lack p53 tumor suppressor function show an exaggerated SASP, suggesting the SASP is negatively controlled by p53. Here, we show that increased p53 activity caused by small molecule inhibitors of MDM2, which promotes p53 degradation, reduces inflammatory cytokine production by senescent cells. Upon treatment with the MDM2 inhibitors nutlin-3a or MI-63, human cells acquired a senescence-like growth arrest, but the arrest was reversible. Importantly, the inhibitors reduced expression of the signature SASP factors IL-6 and IL-1α by cells made senescent by genotoxic stimuli, and suppressed the ability of senescent fibroblasts to stimulate breast cancer cell aggressiveness. Our findings suggest that MDM2 inhibitors could reduce cancer progression in part by reducing the pro-inflammatory environment created by senescent cells. SCIENTIFIC STUDIES A Computational Analysis Of Binding Modes And Conformation Changes Of MDM2 Induced By P53 And Inhibitor Bindings A Dimethylbromobenzene-Cysteine Stapled Peptide Dual Inhibitor Of The P53-MDM2/Mdmx Interactions A Gene Signature Composed Of 13 P53 Target Genes Predicts For Response To Nvp-Cgm097, A Novel P53-MDM2 Inhibitor, In Cell Lines And In Human Primary Tumor … A Novel Orally Active MDM2 Inhibitor (Mi-219) Activates The P53 Pathway And Is Selectively Toxic To Tumor Cells A novel small molecular inhibitor targets the MDM2-p53 interaction significantly reducing cell viability in both embryonal and alveolar rhabdomyosarcoma cells with wild-type p53 A Novel Small Molecule Inhibitor Of MDM2-P53 (Apg-115) Enhances Radiosensitivity Of Gastric Adenocarcinoma A Novel Small Molecule Inhibitor Of MDM2-P53 (Apg-115) Has Antitumor Activity In Gastric Adenocarcinoma A Potent Small-Molecule Inhibitor Of The MDM2–P53 Interaction (Mi-888) Achieved Complete And Durable Tumor Regression In Mice Abstract 2658: 18F-FLT PET imaging for noninvasive, early assessment of tumor response to MDM2-p53 disruption using a novel MDM2 inhibitor Abstract 5505: Synergistic anticancer activity of clinical stage, non-genotoxic apoptosis inducing agents RG7388 (MDM2 antagonist) and ABT-199 (GDC-0199, BCL2 inhibitor) in p53 wild-type AML tumor models Abstract B35: Reactivation Of P53 Signaling In Hepatoblastoma With A Stapled Peptide Dual Inhibitor Of MDM2 And Mdm4 Abstract P1-03-02: Preclinical Efficacy Of A Novel And Potent Inhibitor Of The MDM2-P53 Axis Amg 232 In Er+ Breast Cancer Model Abstract P3-07-21: Cytotoxic Potential Of The Rg7388 MDM2-P53 Binding Antagonist And The Gsk2830371 Wip1 Inhibitor On Mx-1 And Mcf-7 Human Breast Cancer … Activation Of P53 By The MDM2 Inhibitor Rg7112 Impairs Thrombopoiesis Activation of p53 in the tumor microenvironment by MDM2 inhibitor APG-115 synergizes with PD-1 blockade independently of p53 status of tumor cells Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21) Adaptation Of Cancer Cells From Different Entities To The MDM2 Inhibitor Nutlin-3 Results In The Emergence Of P53-Mutated Multi-Drug-Resistant Cancer Cells Amelioration Of Radiation Esophagitis By Orally

… : VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway (oncogene,(2018), 37, 41,(5585 … … and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation … and hormonal aspects of 6 human neoplasias with special emphasis on the presentation of the topological features of oncogene activation tumor suppressor gene … … associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation … b-lineage proto-oncogene b–deficient mice have similar functional outcomes in T cells but DGKζ-deficient mice have increased T cell activation and tumor clearance … chemically induced ha‐ras mutation and transformation of BALB/c 3T3 cells: Evidence for chemical‐specific activation and cell type—specific recruitment of oncogene … … coffee intake and serum concentrations of some organochlorine compounds are independently associated with the mutational activation of the K-ras oncogene. … energy particle radiation-associated oncogenic transformation in normal mice: insight into the connection between activation of oncotargets and oncogene … … Epstein–Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases … of chlordane in B6C3F1 and B6D2F1 male mice: evidence for regression in B6C3F1 mice and carcinogenesis independent of ras proto-oncogene activation … of CXC chemokines, growth-related oncogene α expression, and epithelial cell-derived neutrophil-activating protein-78 by ML-1 (interleukin-17F) involves activation … … of the chemokines monocyte chemotactic protein-1, regulated on activation normal T cell expressed and secreted protein, growth-related oncogene, and interferon-γ … … Overexpression of the Wild-Type Gsα as the gsp oncogene Initiates Chronic Extracellularly Regulated Kinase 1/2 Activation and Hormone Hypersecretion in Pituitary … … pathway in response to human papillomavirus infection and over‐expressionof interleukin‐32 controls the expression of the humanpapillomavirus oncogene … pathway through F‐actin: F‐Actin, assembled in response to Galpha12/13 induced RhoA‐GTP, promotes dephosphorylation and activation of the YAP oncogene … T lymphocytes (CTLs) by human dendritic cells infected with an attenuated influenza A virus expressing a CTL epitope derived from the HER-2/neu proto-oncogene 1O Double PIK3CA mutations in cis enhance PI3Kα oncogene activation and sensitivity to PI3Kα inhibitors in breast cancer 291. A Novel Safety Assay for Retroviral Vectors That Reproduces Lmo2 Proto-oncogene Insertional Activation Events A complex containing PBX2 contributes to activation of the proto-oncogene HOX11 A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene A human cellular sequence implicated in trk oncogene activation is DNA damage inducible. A new mechanism of oncogenic activation: E26 retroviral v-ets oncogene has inverted the C-terminal end of the transcription factor c-ets-1 A repetitive element containing a critical tyrosine residue is required for transcriptional activation by the EWS/ATF1 oncogene A role for substance P in cancer promotion and progression: a mechanism to counteract intracellular death signals following oncogene activation or DNA damage A role for Z-DNA in transcriptional activation of the human c-myc oncogene by the vaccinia virus E3L protein A short-lived nuclear phosphoprotein encoded by the human