A 1: 1 Pharmaceutical Cocrystal Of Myricetin In Combination With Uncommon Piracetam Conformer: X-Ray Single Crystal Analysis And Mechanochemical Synthesis A Comparative Dft Study On Antioxidant-Related Properties Of Myricetin A Comparative Hplc Analysis Of Myricetin, Quercetin And Kaempferol Flavonoids Isolated From Gambian And Indian Moringa Oleifera Leaves A Computational Investigation On The Antioxidant Potential Of Myricetin 3,4′-Di-O-Α-L-Rhamnopyranoside A Convenient Semisynthesis Of Myricetin-3-O-Β-D-Glucuronide A Dft-Based Study Of The Hydrogen-Bonding Interactions Between Myricetin And Ethanol/Water A Multi-Targeted Natural Flavonoid Myricetin Suppresses Lamellipodia And Focal Adhesions Formation And Impedes Glioblastoma Cell Invasiveness And Abnormal Motility A Myricetin Tetramethyl Ether From The Leaf And Stem Surfaces Of Tillandsia Usneoides A New Method For Determination Of Myricetin And Quercetin Using Solid Phase Microextraction–High Performance Liquid Chromatography–Ultra Violet/Visible System In … A New Myricetin-Rhamnodiglucoside From Camellia Sinensis A Novel Strategy For Pharmaceutical Cocrystal Generation Without Knowledge Of Stoichiometric Ratio: Myricetin Cocrystals And A Ternary Phase Diagram A Steady‐State And Time‐Resolved Fluorescence, Circular Dichroism Study On The Binding Of Myricetin To Bovine Serum Albumin A Study On The Effects Of Myricetin On Endothelial Injury In A Cellular Model Of Hyperhomocysteinaemia A Switch Between Antioxidant And Prooxidant Properties Of The Phenolic Compounds Myricetin, Morin, 3′, 4′-Dihydroxyflavone, Taxifolin And 4-Hydroxy-Coumarin … Abrasive Stripping Voltammetry Of Myricetin And DihydroMyricetin Activation Of Nrf2/Ho-1 Signal With Myricetin For Attenuating Ecm Degradation In Human Chondrocytes And Ameliorating The Murine Osteoarthritis Activity Of Myricetin And Other Plant-Derived Polyhydroxyl Compounds In Human Ldl And Human Vascular Endothelial Cells Against Oxidative Stress Adsorption Chromatography Separation Of The Flavonols Kaempferol, Quercetin And Myricetin Using Cross‐Linked Collagen Fibre As The Stationary Phase Afm And Force Spectroscopy Studies On The Interaction Of Myricetin And Myricitrin With Model And Biological Cell Membranes Against Xanthomonas Oryzae Pv. Oryzae, Xanthomonas Axonopodis Pv. Citri And Ralstonia Solanacearum Of Novel Myricetin Derivatives Containing Sulfonamide … Akt Is A Direct Target For Myricetin To Inhibit Cell Transformation Alleviative Effect Of Myricetin On Ochratoxin A-Induced Oxidative Stress In Rat Renal Cortex: Histological And Biochemical Study. Ameliorative Effect Of Myricetin On Insulin Resistance In Mice Fed A High-Fat, High-Sucrose Diet Amination, A Newly Discovered Metabolic Pathway Of Myricetin And Baicalein Analgesic Activity Of Myricetin Isolated From Myrica Rubra Sieb. Et Zucc. Leaves Antagonistic Effect Of Myricetin On Platelet Activing Factor Anti-Allergic Effect Of Bee Pollen Phenolic Extract And Myricetin In Ovalbumin-Sensitized Mice Anti-Allodynic Effect Of The Flavonoid Myricetin In A Rat Model Of Neuropathic Pain: Involvement Of P38 And Protein Kinase C Mediated Modulation Of Ca2+ Channels Antibacterial Activity Of Myricetin In Vitro Anti-Cancer Activity Of Myricetin Against Human Papillary Thyroid Cancer Cells Involves Mitochondrial Dysfunction–Mediated Apoptosis Anti-Hiv-1 Activity Of Flavonoid Myricetin On Hiv-1 Infection In A Dual-Chamber In Vitro Model Anti-Inflammatory Activity Of Myricetin From Diospyros Lotus Through Suppression Of Nf-Κb And Stat1 Activation And Nrf2-Mediated Ho-1 Induction In … Anti-Inflammatory Activity Of Myricetin Isolated From Myrica Rubra Sieb. Et Zucc. Leaves Anti-Inflammatory Activity Of Myricetin-3-O-Β-D-Glucuronide And Related Compounds Anti-Inflammatory Effects Of Kaempferol, Myricetin, Fisetin And Ibuprofen In Neonatal Rats Antinociceptive And Anti-Inflammatory Effects Of Myricetin
Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury PEA and Luteolin synergistically reduce mast cell-mediated toxicityand elicit neuroprotection in cell-based models of brain ischemia Neuroprotection of LuteolinAgainst Aβ_(25-35) Induced Neural Damage Luteolin downregulates TLR4, TLR5, NF-κB and p-p38MAPK expression, upregulates the p-ERK expression, and protects rat brains against focal ischemia Luteolin reduced the traumatic brain injury-induced memory impairments in rats: Attenuating oxidative stress and dark neurons of Hippocampus Ameliorating effect of Luteolin on memory impairment in an Alzheimer's disease model Erratum to: A new co-ultramicronized composite including palmitoylethanolamide and Luteolin to prevent neuroinflammation in spinal cord injury The effects of C-glycosylation of Luteolin on its antioxidant, anti-Alzheimer’s disease, anti-diabetic, and anti-inflammatory activities Neuroprotection by Association of Palmitoylethanolamide with Luteolin in Experimental Alzheimer’s Disease Models: The Control of Neuroinflammation Simultaneous electroanalytical determination of Luteolin and rutin using artificial neural networks Luteolin as a potential preventive and therapeutic candidate for Alzheimer's disease Luteolin Exerts Neuroprotective Effect by Up-regulation of HO-1 via JNK Pathway in Primary Cultured Rat Cortical Cells Postischemic administration of liposome-encapsulated Luteolin prevents against ischemia-reperfusion injury in a rat middle cerebral arteryocclusion model Neurotrophic and Cytoprotective Action of Luteolin in PC12 Cells through ERK-Dependent Induction of Nrf2-Driven HO-1 Expression Neuroprotective effect of Luteolin on amyloid β protein (25–35)‐induced toxicity in cultured rat cortical neurons Brain Inflammation, Neuropsychiatric Disorders, and Immunoendocrine Effects of Luteolin Luteolin promotes long-term potentiation and improves cognitive functions in chronic cerebral hypoperfused rats Protective role of Luteolin against cognitive dysfunction induced by chronic cerebral hypoperfusion in rats Luteolin as an anti-inflammatory and neuroprotective agent: A brief review Protective effects of Luteolin against cognitive impairment induced by infusion of Aβ peptide in rats The anti-amnesic effects of Luteolin against amyloid β25–35 peptide-induced toxicity in mice involve the protection of neurovascular unit Luteolin protects against high fat diet-induced cognitive deficits in obesity mice Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons Pharmacodynamic Effect of Luteolin Micelles on Alleviating Cerebral Ischemia Reperfusion Injury Luteolin Reduces Zinc-Induced Tau Phosphorylation at Ser262/356 in an ROS-Dependent Manner in SH-SY5Y Cells Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice Effects of Luteolin onlearning acquisition in rats: Involvement of the central cholinergic system Luteolin Inhibits Microglial Inflammation and Improves Neuron Survival Against Inflammation Luteolin reduces primary hippocampal neurons death induced by neuroinflammation Luteolin improves the impaired nerve functions in diabetic neuropathy: behavioral and biochemical evidences Neuroprotective effects of Luteolin against apoptosis induced by 6-hydroxydopamine on rat pheochromocytoma PC12 cells Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice Luteolin protects the hippocampus against neuron impairments induced by kainic acid in rats Protective properties of quercetin and Luteolin from Petasites japonicus leaves against Aβ (25–35)-induced neurotoxicity in B103 cells Therapeutic potential of Luteolin in transgenic Drosophila model of Alzheimer’s disease Luteolin Could Improve Cognitive Dysfunction by Inhibiting Neuroinflammation Cellular uptake of quercetin and Luteolin and their effects on monoamine oxidase-A in human neuroblastoma SH-SY5Y cells Luteolin attenuates neuronal apoptosis in the hippocampi of diabetic encephalopathy
MTOR: The Rapid Aging Pathway “The mammalian target of rapamycin(mTOR), also known as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene.[5][6][7] mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.[8] mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes.[9] In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription.[9][10] As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors.[11]mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton.[9][12] mTOR integrates the input from upstream pathways, including insulin, growth factors (such as IGF-1 and IGF-2), and amino acids.[10] mTOR also senses cellular nutrient, oxygen, and energy levels.[27] The mTOR pathway is a central regulator of mammalian metabolism and physiology, with important roles in the function of tissues including liver, muscle, white and brown adipose tissue,[28] and the brain, and is dysregulated in human diseases, such as diabetes, obesity, depression, and certain cancers.[29][30] Decreased TOR activity has been found to increase life span in S. cerevisiae, C. elegans, and D. melanogaster.[61][62][63][64] The mTOR inhibitor rapamycin has been confirmed to increase lifespan in mice.[65][66][67][68][69] It is hypothesized that some dietary regimes, like caloric restriction and methionine restriction, cause lifespan extension by decreasing mTOR activity.[61][62] Some studies have suggested that mTOR signaling may increase during aging, at least in specific tissues like adipose tissue, and rapamycin may act in part by blocking this increase.[70] An alternative theory is mTOR signaling is an example of antagonistic pleiotropy, and while high mTOR signaling is good during early life, it is maintained at an inappropriately high level in old age. Calorie restriction and methionine restriction may act in part by limiting levels of essential amino acids including leucine and methionine, which are potent activators of mTOR.[71] The administration of leucine into the rat brain has been shown to decrease food intake and body weight via activation of the mTOR pathway in the hypothalamus.[72] According to the free radical theory of aging,[73] reactive oxygen species cause damage of mitochondrial proteins and decrease ATP production. Subsequently, via ATP sensitive AMPK, the mTOR pathway is inhibited and ATP consuming protein synthesis is downregulated, since mTORC1 initiates a phosphorylation cascade activating the ribosome.[16] Hence, the proportion of damaged proteins is enhanced. Moreover, disruption of mTORC1 directly inhibits mitochondrial respiration.[74]These positive feedbacks on the aging process are counteracted by protective mechanisms: Decreased mTOR activity (among other factors) upregulates glycolysis[74] and removal of dysfunctional cellular components via autophagy.[73]“ — Wikipedia Simplified in plain English: KEEP MTOR TURNED OFF as often as possible. MTOR = RAPID AGING. You want ZERO amino acids (ie. protein),
… -Resolved Spectral Studies of Blue−Green Fluorescence of Artichoke (Cynara cardunculus L. Var. Scolymus) Leaves: Identification of Chlorogenic Acid as One of … … , angiotensin converting enzyme and ecto‐enzymes of purinergic system: Ameliorative properties of caffeic and Chlorogenic Acid in hypercholesterolemic rats … . Extract depends upon attenuation of osteoclast differentiation and bone resorption-associated acidification due to Chlorogenic Acid , Hyperoside, and Scoparone … A commentary on" Salivary uric acid at the acidic pH of the stomach is the principal defense against nitrite-derived reactive species: Sparing effects of Chlorogenic Acid … … acid and Chlorogenic Acid , and activities of peroxidase and superoxide dismutase in the apoplast of tobacco leaves: mechanism of the oxidation of Chlorogenic Acid in … … and analysis of CYP450 genes from transcriptome of Lonicera japonica and expression analysis of Chlorogenic Acid biosynthesis related CYP450s … and characterization of nine tissues of Lonicera japonica to identify potential candidate genes involved in Chlorogenic Acid , luteolosides, and secoiridoid … … AND MECHANISTIC APPROACH TO PROTECTION AND REPAIR OF TERT-BUTOXYL RADICALS INDUCED URACIL RADICALS BY Chlorogenic Acid … and related compounds from medicinal plants and drugs. VII. Effects of extracts of leaves of Artemisia species, and caffeic acid and Chlorogenic Acid on lipid metabolic … … and renewal of Chlorogenic Acid and related depsides in the genus Coffea. II. Incorporation of the radioactivity of L-phenylalanine-[14 C] in the Chlorogenic Acid of … … and vasodilator effects of methanolic extract of Inula viscosa: Biological evaluation and POM analysis of cynarin, Chlorogenic Acid as potential hypertensive … arabica L.'Laurina'and C. arabica 'Bourbon'seedlings grown in daylight or darkness for their polysaccharidic cell wall composition and caffeine and Chlorogenic Acid … … Biosensor for Detection of Target DNA Sequence and Single-Base Mismatch Related to Helicobacter Pylori Using Chlorogenic Acid as Hybridization Indicator … Chaetomium cupreum chemically enhances aluminium tolerance in Miscanthus sinensis via increasing the aluminium detoxicants, Chlorogenic Acid and … … comparing principal component analysis using data derived from CD-, NMR-and IR-spectroscopies and LC-MS in the analysis of the Chlorogenic Acid fraction in green … … dispersive micro-solid phase extraction with the CuO/ZnO@ Fe 3 O 4-CNTs nanocomposite sorbent for the rapid pre-concentration of Chlorogenic Acid in the medical … … dispersive micro-solid phase extraction with the CuO/ZnO@ Fe3O4-CNTs nanocomposite sorbent for the rapid pre-concentration of Chlorogenic Acid in the medical … … Does not affect gluconeogenesis but directs gluconeogenic flux toward glycogen in fasted rats A PHARMACOLOGICAL STUDY WITH THE Chlorogenic Acid … … effects between different classes of secondary metabolites on insect herbivores: a case study on pyrrolizidine alkaloid N-oxides and Chlorogenic Acid … FUSARIUM OXYSPORUM F. SP. NIVEUM.[WTHZ] AND THE RELATION BETWEEN RESISTANCE AND VARIATIONS OF Chlorogenic Acid AND FERULIC ACID … … geometry, stoichiometry, and thermodynamics of cyclomalto-oligosaccharide (cyclodextrin) inclusion complex formation with Chlorogenic Acid , the major substrate of … … HYDROXYCINNAMOYL TRANSFERASE (HQT): EFFECTS OF GENE MODULATION IN PHENYLPROPANOID PATHWAY ON LIGNIN AND Chlorogenic Acid … … imprinted polymer for caffeic acid by precipitation polymerization
A Novel Process To Produce Stabilized Carnosic Acid In High Concentration A Rosemary Extract Enriched In Carnosic Acid Improves Circulating Adipocytokines And Modulates Key Metabolic Sensors In Lean Zucker Rats: Critical And Contrasting … A Rosemary Extract Rich In Carnosic Acid Selectively Modulates Caecum Microbiota And Inhibits Β-Glucosidase Activity, Altering Fiber And Short Chain Fatty Acids … A Systematic Study On The Interactions Between Carnosic Acid And Ethylpyrrolidine Methacrylate–Methyl Methacrylate Copolymer In Supercritical Media Absorption, Distribution And Elimination Of Carnosic Acid, A Natural Antioxidant From Rosmarinus Officinalis, In Rats Abstract B45: Carnosic Acid From Rosemary Induces Degradation Of Androgen Receptor And Is Critically Regulated By The Er Stress Protein Chop Activated Glutathione Metabolism Participates In Protective Effects Of Carnosic Acid Against Oxidative Stress In Neuronal Ht22 Cells Activation Of The Sirt1/P66Shc Antiapoptosis Pathway Via Carnosic Acid-Induced Inhibition Of Mir-34A Protects Rats Against Nonalcoholic Fatty Liver Disease Acute And 30-Day Oral Toxicity Studies Of Administered Carnosic Acid Administration Of The Nrf2–Are Activators Sulforaphane And Carnosic Acid Attenuates 4-Hydroxy-2-Nonenal-Induced Mitochondrial Dysfunction Ex Vivo Advances In Studies On Carnosic Acid From Rosmarinus Officinalis L. Alpha-Tocopherol-Based Microemulsion Improving The Stability Of Carnosic Acid And Its Electrochemical Analysis Of Antioxidant Activity Amyloid-Β 1–42 (Aβ42) On Human Neuroblastoma Sh-Sy5Y Cell Viability: Neuroprotective Potential Of Combination Use With Carnosic Acid, Rebamipide, Edaravone, And … An Expeditious Synthetic Route To Carnosic Acid Type Diterpenes An Integrated Proteomics And Bioinformatics Approach Reveals The Anti-Inflammatory Mechanism Of Carnosic Acid An Intrinsically Labile Α-Helix Abutting The Bcl9-Binding Site Of Β-Catenin Is Required For Its Inhibition By Carnosic Acid And Validation Of An Analytical Method Based On Hplc-Elsd For The Simultaneous Determination Of Rosmarinic Acid, Carnosol, Carnosic Acid, Oleanolic Acid And … Antiadipogenic Effect Of Carnosic Acid, A Natural Compound Present In Rosmarinus Officinalis, Is Exerted Through The C/Ebps And Pparγ Pathways At The Onset Of The … Antiangiogenic Effect Of Carnosic Acid And Carnosol, Neuroprotective Compounds In Rosemary Leaves Anti-Angiogenic Properties Of Carnosol And Carnosic Acid, Two Major Dietary Compounds From Rosemary Anti-Clastogenic Potential Of Carnosic Acid Against 7, 12-Dimethylbenz (A) Anthracene (Dmba)-Induced Clastogenesis Anti‐Inflammatory Activity Of Rosemary Extracts Obtained By Supercritical Carbon Dioxide Enriched In Carnosic Acid And Carnosol Anti‐Inflammatory And Analgesic Activity Of Carnosol And Carnosic Acid In Vivo And In Vitro And In Silico Analysis Of Their Target Interactions Anti-Inflammatory Effects Of Supercritical Carbon Dioxide Extract And Its Isolated Carnosic Acid From Rosmarinus Officinalis Leaves Antimicrobial Activity Of Carnosic Acid Isolated From Rosmarinus Officinalis L. Leaves Antimicrobial Activity Of Rosmarinus Officinalis Against Oral Pathogens: Relevance Of Carnosic Acid And Carnosol Anti-Mrsa Activity Of Carnosic Acid In Rosemary [J] Antioxidant Activities Of Rosemary (Rosmarinus Officinalis L.) Extract, Blackseed (Nigella Sativa L.) Essential Oil, Carnosic Acid, Rosmarinic Acid And Sesamol Antioxidant Activity And Oxidative Stability To Fish Oil Of Carnosic Acid [J] Antioxidant Activity Of A Rosemary Extract And Its Constituents, Carnosic Acid, Carnosol, And Rosmarinic Acid, In Bulk Oil And Oil-In-Water Emulsion Antioxidant Activity Of Carnosic Acid And Methyl Carnosate In Bulk Oils And Oil-In-Water Emulsions Antioxidant Activity Of