AMPK activation: a therapeutic target for type 2 diabetes? AMPK activators–potential therapeutics for metabolic and other diseases AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure Choreography of AMPK activation Use of cells expressing γ subunit variants to identify diverse mechanisms of AMPK activation Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome Effect of AMPK activation on muscle glucose metabolism in conscious rats AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma Antileukemic effects of AMPK activators on BCR-ABL–expressing cells Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation A small molecule AMPK activator protects the heart against ischemia–reperfusion injury SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth Berberine suppresses proinflammatory responses through AMPK activation in macrophages Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation Suppression of AMPK activation via S485 phosphorylation by IGF-I during hyperglycemia is mediated by AKT activation in vascular smooth muscle cells Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation Structural basis of AMPK regulation by small molecule activators Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation AICAR, an AMPK activator, has protective effects on alcohol‐induced fatty liver in rats AMPK activation—protean potential for boosting healthspan Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect AMPK activation regulates neuronal structure in developing hippocampal neurons AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2α in adipocytes AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/β-catenin signaling activity Berberine-induced AMPK activation

Immunoregulatory functions of mTOR inhibition Dissecting the role of mTOR: lessons from mTOR inhibitors Updates of mTOR inhibitors mTOR inhibitors: an overview The pharmacology of mTOR inhibition Current development of mTOR inhibitors as anticancer agents Functional consequences of mTOR inhibition mTOR inhibitors in the treatment of cancer Will mTOR inhibitors make it as cancer drugs? mTOR pathway and mTOR inhibitors as agents for cancer therapy Deforolimus (AP23573) a novel mTOR inhibitor in clinical development mTOR inhibitor/proliferation signal inhibitors: entering or leaving the field? The biology behind mTOR inhibition in sarcoma Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy Predicted mechanisms of resistance to mTOR inhibitors mToR inhibitors-induced proteinuria: mechanisms, significance, and management mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt The applicability of mTOR inhibition in solid tumors Enhanced radiation damage of tumor vasculature by mTOR inhibitors The potential role of mTOR inhibitors in non-small cell lung cancer A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma The role of mTOR inhibitors in the management of posttransplant malignancy Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma mTOR inhibitor‐associated dermatologic and mucosal problems DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival mTOR inhibitor RAD001 (everolimus) has antiangiogenic/vascular properties distinct from a VEGFR tyrosine kinase inhibitor The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation PI3K/AKT/mTOR inhibitors in ovarian cancer mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways Prospects for mTOR inhibitor use in patients with polycystic kidney disease and hamartomatous diseases PI3K and mTOR inhibitors—a new generation of targeted anticancer agents Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer The emerging safety profile of mTOR inhibitors, a novel class of anticancer agents Overcoming cisplatin resistance by mTOR inhibitor in lung cancer Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas Oral mTOR inhibitor everolimus in patients with gemcitabine-refractory metastatic pancreatic cancer Novel and evolving therapies in the treatment of malignant phaeochromocytoma: experience with the mTOR inhibitor everolimus (RAD001) Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition A Phase II trial of the oral mTOR inhibitor everolimus in relapsed Hodgkin lymphoma Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program mTOR inhibitors in polycystic kidney disease mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia Biomarker development for the clinical activity of the mTOR inhibitor everolimus (RAD001): processes, limitations, and further proposals Treatment with the mTOR inhibitor temsirolimus in patients with malignant

The Warburg effect: 80 years on The Warburg effect: how does it benefit cancer cells? The Warburg effect in 2012 We need to talk about the Warburg effect The Warburg effect: insights from the past decade The Warburg effect 97 years after its discovery The Warburg effect and its cancer therapeutic implications The Warburg effect: evolving interpretations of an established concept Understanding the Warburg effect: the metabolic requirements of cell proliferation The Warburg effect then and now: from cancer to inflammatory diseases New aspects of the Warburg effect in cancer cell biology The Warburg effect and drug resistance Cancer's molecular sweet tooth and the Warburg effect Warburg effect and its role in tumourigenesis Involvement of the Warburg effect in non‐tumor diseases processes Metabolic changes in cancer: beyond the Warburg effect The Warburg effect and the hallmarks of cancer Warburg effect or reverse Warburg effect? A review of cancer metabolism The Warburg effect: molecular aspects and therapeutic possibilities Cancer metabolism: the Warburg effect today Warburg effect-a consequence or the cause of carcinogenesis? Warburg effect and redox balance Energy boost: the Warburg effect returns in a new theory of cancer Beyond Warburg effect–dual metabolic nature of cancer cells Warburg effect (s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism From Warburg effect to Reverse Warburg effect; the new horizons of anti-cancer therapy Post-translational modifications and the Warburg effect Tumour-associated mutant p53 drives the Warburg effect The Warburg effect and mitochondrial stability in cancer cells Cellular life span and the Warburg effect The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect How the Warburg effect supports aggressiveness and drug resistance of cancer cells? The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect The Warburg effect revisited—lesson from the Sertoli cell Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited Cancer metabolism in space and time: beyond the Warburg effect Emergence of spatial structure in the tumor microenvironment due to the Warburg effect AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo Transcriptional regulation of the Warburg effect in cancer by SIX1 Regulation of the Warburg effect in early-passage breast cancer cells Nuclear PKM2 regulates the Warburg effect The warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? Rethinking the Warburg effect with Myc micromanaging glutamine metabolism Metabolic pathways of the Warburg effect in health and disease: perspectives of choice, chain or chance Reversing the Warburg effect as a treatment for glioblastoma A critical review of the role of M2PYK in the Warburg effect A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect The Warburg effect

Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammaging in a D-galactose-induced accelerated aging mouse model Tanshinone I enhances learning and memory, and ameliorates memory impairment in mice via the extracellular signal‐regulated kinase signalling pathway Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ1–42 oligomer injection Angelica polysaccharide ameliorates memory impairment in Alzheimer's disease rat through activating BDNF/TrkB/CREB pathway Dihydromyricetin ameliorates memory impairment induced by acute sleep deprivation Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model Chronic ghrelin administration restores hippocampal long‐term potentiation and ameliorates memory impairment in rat model of Alzheimer's disease Dexmedetomidine ameliorates memory impairment in sleep-deprived mice Guarana (Paullinia cupana) ameliorates memory impairment and modulates acetylcholinesterase activity in Poloxamer-407-induced hyperlipidemia in rat … Berberine exerts an anticonvulsant effect and ameliorates memory impairment and oxidative stress in a pilocarpine-induced epilepsy model in the rat Treadmill exercise ameliorates memory impairment through ERK-Akt-CREB-BDNF signaling pathway in cerebral ischemia gerbils Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice Anticonvulsant effect of piperine ameliorates memory impairment, inflammation and oxidative stress in a rat model of pilocarpine-induced epilepsy Xanthohumol ameliorates memory impairment and reduces the deposition of β-amyloid in APP/PS1 mice via regulating the mTOR/LC3II and Bax/Bcl-2 signalling … Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway (−)-Epigallocatechin-3-gallate ameliorates memory impairment and rescues the abnormal synaptic protein levels in the frontal cortex and hippocampus in a mouse … GJ-4 ameliorates memory impairment in focal cerebral ischemia/reperfusion of rats via inhibiting JAK2/STAT1-mediated neuroinflammation Deferiprone ameliorates memory impairment in Scopolamine-treated rats: The impact of its iron-chelating effect on β-amyloid disposition The phosphodiesterase type-5 inhibitor, tadalafil, improves depressive symptoms, ameliorates memory impairment, as well as suppresses apoptosis and enhances … 2,2′,4′‐Trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice Phytoestrogen α-zearalanol ameliorates memory impairment and neuronal DNA oxidation in ovariectomized mice Oxymatrine ameliorates memory impairment in diabetic rats by regulating oxidative stress and apoptosis: involvement of NOX2/NOX4 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2-and H3 … Danggui-Jakyak-San ameliorates memory impairment and increase neurogenesis induced by transient forebrain ischemia in mice 17-AAG post-treatment ameliorates memory impairment and hippocampal CA1 neuronal autophagic death induced by transient global cerebral ischemia Cotinine ameliorates memory and learning impairment in senescent mice The novel nootropic compound DM232 (UNIFIRAM) ameliorates memory impairment in mice and rats Kisspeptin-13 ameliorates memory impairment induced by streptozotocin in male rats via cholinergic system Sodium valproate ameliorates memory impairment and reduces the elevated levels of apoptotic caspases in the hippocampus of diabetic mice Preischemic treadmill exercise ameliorates memory impairment and microvasculature damage in rat model of chronic cerebral hypoperfusion A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice Combination of proanthocyanidins extracted from lotus seedpod and l-cysteine ameliorates memory impairment

Saponins, classification and occurrence in the plant kingdom Biological activities and distribution of plant saponins Saponins and plant defence—a soap story A mechanism for the hypocholesterolaemic activity of saponins Chromatographic determination of plant saponins Chromatographic determination of plant saponins—an update (2002–2005) Saponins from edible legumes: chemistry, processing, and health benefits Saponins from Allium minutiflorum with antifungal activity Mechanism of antiviral activity of triterpenoid saponins Saponins in pulses and their health promoting activities: A review Saponins versus plant fungal pathogens Antimicrobial activity of saponins from Medicago sp.: structure‐activity relationship Investigations of the mechanism of membrane activity of selected triterpenoid saponins Antimicrobial activity of saponins from Acacia auriculiformis Effect of saponins on the growth and activity of rhizosphere bacteria Effects of saponins on lipid metabolism: A review of potential health benefits in the treatment of obesity In vitro antifungal activity of triterpenoid saponins Evaluation of the antimicrobial activity of saponins extract of Sorghum bicolor L. Moench The impact of saponins or saponin-containing plant materials on ruminant production A Review Novel advances with plant saponins as natural insecticides to control pest insects In vitro determination of the spermicidal activity of plant saponins Plant-derived saponins: a review of their surfactant properties and applications Characterization and antimutagenic activity of soybean saponins Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex. Structure-activity relationships of haemolytic saponins Anti-tumor activity of the crude saponins obtained from asparagus Chemical and Biological Activity of Triterpene Saponins from Medicago Species Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins Cytotoxic activity of some triterpenoid saponins Role of saponins in plant defense against specialist herbivores Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance Anti-inflammatory activity of unusual lupane saponins from Bupleurum fruticescens Steroidal saponins from Asparagus officinalis and their cytotoxic activity Saponins with biological and pharmacological activity Saponins of the ivy plant, Hedera helix, and their leishmanicidic activity In vivo anti-inflammatory activity of saponins from Bupleurum rotundifolium Five New Steroidal Saponins from Solanum chrysotrichum Leaves and Their Antimycotic Activity Structure and hemolytic activity relationships of triterpenoid saponins and sapogenins Commercial utilization of plant-derived saponins: an overview of medicinal, pharmaceutical, and industrial applications Structural analogues of diosgenyl saponins: synthesis and anticancer activity Production of plant bioactive triterpenoid saponins: elicitation strategies and target genes to improve yields Soybean saponins. Fate of ingested soybean saponins and the physiological aspect of their hemolytic activity Challenges associated with elucidating the mechanisms of the hypocholesterolaemic activity of saponins Anthelmintic activity of steroidal saponins from Paris polyphylla Open-chain steroidal glycosides, a diverse class of plant saponins Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro A review of ultrasound-assisted extraction for plant bioactive compounds: Phenolics, flavonoids, thymols, saponins and proteins Antitumor activity of Pulsatilla koreana saponins and their structure–activity relationship Flavonoids and saponins in plant rhizospheres: roles, dynamics, and the potential for agriculture Control of insect pests in crop plants and stored food grains using plant saponins: A review Production of plant bioactive triterpenoid